Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35F3 Gene

Aliases for SLC35F3 Gene

  • Solute Carrier Family 35 Member F3 2 3 4 5
  • Solute Carrier Family 35, Member F3 2

External Ids for SLC35F3 Gene

Previous GeneCards Identifiers for SLC35F3 Gene

  • GC01P231124
  • GC01P230347
  • GC01P232107
  • GC01P234040
  • GC01P204531

Summaries for SLC35F3 Gene

GeneCards Summary for SLC35F3 Gene

SLC35F3 (Solute Carrier Family 35 Member F3) is a Protein Coding gene. An important paralog of this gene is SLC35F4.

UniProtKB/Swiss-Prot for SLC35F3 Gene

  • May be a thiamine transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F3 Gene

Genomics for SLC35F3 Gene

Regulatory Elements for SLC35F3 Gene

Enhancers for SLC35F3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35F3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35F3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35F3 Gene

233,904,712 bp from pter
234,324,518 bp from pter
419,807 bases
Plus strand

Genomic View for SLC35F3 Gene

Genes around SLC35F3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F3 Gene

Proteins for SLC35F3 Gene

  • Protein details for SLC35F3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative thiamine transporter SLC35F3
    Protein Accession:
    Secondary Accessions:
    • Q5TDD6
    • Q8N9C9

    Protein attributes for SLC35F3 Gene

    421 amino acids
    Molecular mass:
    46817 Da
    Quaternary structure:
    No Data Available
    • Promotes thiamine uptake when expressed in E.coli. Individuals with blood hypertension and a SLC35F3 risk allele T/T homozygosity (intronic variant rs17514104) show a significant reduction in blood thiamine content.

    Alternative splice isoforms for SLC35F3 Gene


neXtProt entry for SLC35F3 Gene

Proteomics data for SLC35F3 Gene at MOPED

Post-translational modifications for SLC35F3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35F3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35F3 Gene

Domains & Families for SLC35F3 Gene

Gene Families for SLC35F3 Gene

Protein Domains for SLC35F3 Gene

Suggested Antigen Peptide Sequences for SLC35F3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC35F solute transporter family.
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F3: view

Function for SLC35F3 Gene

Molecular function for SLC35F3 Gene

UniProtKB/Swiss-Prot Function:
May be a thiamine transporter.

Phenotypes for SLC35F3 Gene

GenomeRNAi human phenotypes for SLC35F3:
genes like me logo Genes that share phenotypes with SLC35F3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F3

CRISPR Products

miRNA for SLC35F3 Gene

miRTarBase miRNAs that target SLC35F3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F3 Gene

Localization for SLC35F3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC35F3 Gene COMPARTMENTS Subcellular localization image for SLC35F3 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35F3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F3: view

Pathways & Interactions for SLC35F3 Gene

SuperPathways for SLC35F3 Gene

No Data Available

Interacting Proteins for SLC35F3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000355577 for SLC35F3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC35F3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35F3 Gene

Drugs & Compounds for SLC35F3 Gene

No Compound Related Data Available

Transcripts for SLC35F3 Gene

mRNA/cDNA for SLC35F3 Gene

Unigene Clusters for SLC35F3 Gene

Solute carrier family 35, member F3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F3 Gene

No ASD Table

Relevant External Links for SLC35F3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35F3 Gene

mRNA expression in normal human tissues for SLC35F3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35F3 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x6.0), Brain - Cerebellum (x5.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Frontal Cortex (BA9) (x4.4).

Protein differential expression in normal tissues from HIPED for SLC35F3 Gene

This gene is overexpressed in Testis (6.7) and Spleen (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35F3 Gene

SOURCE GeneReport for Unigene cluster for SLC35F3 Gene Hs.158748

genes like me logo Genes that share expression patterns with SLC35F3: view

Protein tissue co-expression partners for SLC35F3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC35F3 Gene

Orthologs for SLC35F3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC35F3 35
  • 92.79 (n)
  • 94.49 (a)
SLC35F3 36
  • 94 (a)
(Canis familiaris)
Mammalia SLC35F3 35
  • 92.71 (n)
  • 95.12 (a)
SLC35F3 36
  • 91 (a)
(Mus musculus)
Mammalia Slc35f3 35
  • 86.75 (n)
  • 91.39 (a)
Slc35f3 16
Slc35f3 36
  • 87 (a)
(Pan troglodytes)
Mammalia SLC35F3 35
  • 99.75 (n)
  • 99.75 (a)
SLC35F3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc35f3 35
  • 87.06 (n)
  • 91.93 (a)
(Monodelphis domestica)
Mammalia SLC35F3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia SLC35F3 36
  • 81 (a)
(Gallus gallus)
Aves SLC35F3 35
  • 80.78 (n)
  • 87.12 (a)
SLC35F3 36
  • 87 (a)
(Anolis carolinensis)
Reptilia SLC35F3 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491052 35
  • 69.3 (n)
  • 74.94 (a)
(Danio rerio)
Actinopterygii slc35f3b 35
  • 70.04 (n)
  • 72.15 (a)
slc35f3a 36
  • 54 (a)
slc35f3b 36
  • 67 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004544 35
  • 45.69 (n)
  • 37.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG42322 35
  • 48.28 (n)
  • 35.86 (a)
CG42322 36
  • 17 (a)
(Caenorhabditis elegans)
Secernentea Y73B6BL.31 35
  • 50.65 (n)
  • 39.22 (a)
Y73B6BL.31 36
  • 28 (a)
Species with no ortholog for SLC35F3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F3 Gene

Gene Tree for SLC35F3 (if available)
Gene Tree for SLC35F3 (if available)

Paralogs for SLC35F3 Gene

Paralogs for SLC35F3 Gene

(1) SIMAP similar genes for SLC35F3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35F3: view

Variants for SLC35F3 Gene

Sequence variations from dbSNP and Humsavar for SLC35F3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17853780 - 234,316,672(+) CCACT(C/G)CGTCA reference, missense
rs474208 -- 234,321,753(-) CAGGG(C/T)CCCCG intron-variant
rs475986 -- 234,248,374(-) CCCAC(C/T)GAACA intron-variant
rs475987 -- 234,248,373(-) CCACT(A/G)AACAA intron-variant
rs476010 -- 234,248,253(-) CAATG(C/G)ACCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F3 Gene

Variant ID Type Subtype PubMed ID
nsv832892 CNV Loss 17160897
nsv506983 CNV Insertion 20534489
esv268052 CNV Insertion 20981092
esv272794 CNV Insertion 20981092
esv1716945 CNV Insertion 17803354
esv2659243 CNV Deletion 23128226
esv272018 CNV Insertion 20981092
esv272225 CNV Insertion 20981092
esv2656563 CNV Deletion 23128226
nsv4899 CNV Insertion 18451855
esv2725118 CNV Deletion 23290073
nsv873313 CNV Loss 21882294
esv33741 CNV Loss 17666407
esv33370 CNV Loss 17666407
nsv832903 CNV Loss 17160897
nsv519237 CNV Loss 19592680
nsv873314 CNV Gain 21882294
nsv819148 CNV Loss 19587683
esv4582 CNV Deletion 18987735
esv2725129 CNV Deletion 23290073
nsv159799 CNV Loss 16902084
esv7223 CNV Loss 19470904
esv990606 CNV Gain 20482838
dgv109n67 CNV Loss 20364138
esv24323 CNV Loss 19812545
esv1005100 CNV Gain 20482838
esv2666716 CNV Deletion 23128226
nsv827342 CNV Loss 20364138
nsv509657 CNV Insertion 20534489
nsv512759 CNV Insertion 21212237
esv2725141 CNV Deletion 23290073
dgv68e201 CNV Deletion 23290073
esv2725185 CNV Deletion 23290073
esv2725196 CNV Deletion 23290073
nsv522312 CNV Loss 19592680
nsv873315 CNV Loss 21882294

Variation tolerance for SLC35F3 Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.69% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC35F3 Gene

Disorders for SLC35F3 Gene

Relevant External Links for SLC35F3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35F3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F3 Gene

Publications for SLC35F3 Gene

  1. Genetic implication of a novel thiamine transporter in human hypertension. (PMID: 24509276) Zhang K. … O'Connor D.T. (J. Am. Coll. Cardiol. 2014) 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3
  4. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SLC35F3 Gene

Sources for SLC35F3 Gene