Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35F2 Gene

Aliases for SLC35F2 Gene

  • Solute Carrier Family 35 Member F2 2 3 5
  • Solute Carrier Family 35, Member F2 2 3
  • Lung Squamous Cell Cancer Related Protein LSCC-3 3
  • HSNOV1 3

External Ids for SLC35F2 Gene

Previous GeneCards Identifiers for SLC35F2 Gene

  • GC11M107199
  • GC11M107166
  • GC11M107661
  • GC11M103587

Summaries for SLC35F2 Gene

GeneCards Summary for SLC35F2 Gene

SLC35F2 (Solute Carrier Family 35 Member F2) is a Protein Coding gene. An important paralog of this gene is SLC35F1.

UniProtKB/Swiss-Prot for SLC35F2 Gene

  • Putative solute transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F2 Gene

Genomics for SLC35F2 Gene

Regulatory Elements for SLC35F2 Gene

Enhancers for SLC35F2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35F2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35F2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35F2 Gene

Chromosome:
11
Start:
107,790,991 bp from pter
End:
107,928,293 bp from pter
Size:
137,303 bases
Orientation:
Minus strand

Genomic View for SLC35F2 Gene

Genes around SLC35F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F2 Gene

Proteins for SLC35F2 Gene

  • Protein details for SLC35F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXU6-S35F2_HUMAN
    Recommended name:
    Solute carrier family 35 member F2
    Protein Accession:
    Q8IXU6
    Secondary Accessions:
    • Q14963
    • Q5JPA8
    • Q6ZRQ3
    • Q9H947

    Protein attributes for SLC35F2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41212 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA68226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F2 Gene

Proteomics data for SLC35F2 Gene at MOPED

Post-translational modifications for SLC35F2 Gene

  • Ubiquitination at Lys 33
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35F2 Gene

Antibody Products

No data available for DME Specific Peptides for SLC35F2 Gene

Domains & Families for SLC35F2 Gene

Gene Families for SLC35F2 Gene

Protein Domains for SLC35F2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXU6

UniProtKB/Swiss-Prot:

S35F2_HUMAN :
  • Belongs to the SLC35F solute transporter family.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F2: view

Function for SLC35F2 Gene

Molecular function for SLC35F2 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.
genes like me logo Genes that share phenotypes with SLC35F2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F2 Gene

Localization for SLC35F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35F2 Gene COMPARTMENTS Subcellular localization image for SLC35F2 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for SLC35F2 Gene

Pathways & Interactions for SLC35F2 Gene

SuperPathways for SLC35F2 Gene

No Data Available

Interacting Proteins for SLC35F2 Gene

Gene Ontology (GO) - Biological Process for SLC35F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLC35F2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F2 Gene

Drugs & Compounds for SLC35F2 Gene

No Compound Related Data Available

Transcripts for SLC35F2 Gene

Unigene Clusters for SLC35F2 Gene

Solute carrier family 35, member F2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for SLC35F2 Gene

GeneLoc Exon Structure for
SLC35F2
ECgene alternative splicing isoforms for
SLC35F2

Expression for SLC35F2 Gene

mRNA expression in normal human tissues for SLC35F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35F2 Gene

This gene is overexpressed in Lung (40.1), Fetal ovary (15.8), and Placenta (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for SLC35F2 Gene



SOURCE GeneReport for Unigene cluster for SLC35F2 Gene Hs.524014

genes like me logo Genes that share expression patterns with SLC35F2: view

Protein tissue co-expression partners for SLC35F2 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35F2 Gene

Orthologs for SLC35F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC35F2 35
  • 88.86 (n)
  • 93.43 (a)
SLC35F2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35f2 35
  • 85.12 (n)
  • 89.84 (a)
Slc35f2 16
Slc35f2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35F2 35
  • 99.6 (n)
  • 99.7 (a)
SLC35F2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC35F2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC35F2 35
  • 73.8 (n)
  • 77.78 (a)
SLC35F2 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35F2 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35f2 35
  • 68.36 (n)
  • 71.75 (a)
Str.1493 35
zebrafish
(Danio rerio)
Actinopterygii Dr.29116 35
slc35f2 35
  • 66.24 (n)
  • 64.52 (a)
slc35f2 36
  • 52 (a)
OneToMany
SLC35F2 (2 of 2) 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.3 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for SLC35F2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F2 Gene

ENSEMBL:
Gene Tree for SLC35F2 (if available)
TreeFam:
Gene Tree for SLC35F2 (if available)

Paralogs for SLC35F2 Gene

Paralogs for SLC35F2 Gene

(1) SIMAP similar genes for SLC35F2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC35F2: view

Variants for SLC35F2 Gene

Sequence variations from dbSNP and Humsavar for SLC35F2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs518852 -- 107,792,064(-) AAGTC(C/T)TGAGA utr-variant-3-prime
rs519965 -- 107,805,971(-) ACCTC(A/G)GTCTC intron-variant
rs522861 -- 107,834,187(+) ggtca(A/G)ttgga intron-variant
rs523601 -- 107,799,748(+) TTGTA(C/T)TTGTA intron-variant
rs523608 -- 107,799,754(+) TTGTA(A/G)AGACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F2 Gene

Variant ID Type Subtype PubMed ID
nsv898378 CNV Gain 21882294
nsv521771 CNV Gain 19592680
nsv527748 CNV Gain 19592680
nsv520229 CNV Gain 19592680
dgv1313n71 CNV Gain 21882294
nsv468867 CNV Loss 19166990
esv23217 CNV Gain 19812545
esv2421534 CNV Duplication 20811451
nsv442244 CNV CNV 18776908
nsv826079 CNV Loss 20364138
esv268186 CNV Insertion 20981092
esv2750980 CNV Gain 17911159
dgv1314n71 CNV Loss 21882294

Variation tolerance for SLC35F2 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC35F2 Gene

Disorders for SLC35F2 Gene

Relevant External Links for SLC35F2

Genetic Association Database (GAD)
SLC35F2
Human Genome Epidemiology (HuGE) Navigator
SLC35F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F2

No disorders were found for SLC35F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F2 Gene

Publications for SLC35F2 Gene

  1. Construction of a transcription map around the gene for ataxia telangiectasia; identification of at least four novel genes. (PMID: 9119394) Stankovic T. … Taylor A.M.R. (Genomics 1997) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. (PMID: 23453885) (Lancet 2013) 3
  5. Highly expressed SLC35F2 in non-small cell lung cancer is associated with pathological staging. (PMID: 21874247) Bu L. … Wang J. (Mol Med Rep 2011) 3

Products for SLC35F2 Gene

Sources for SLC35F2 Gene

Content