Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35F2 Gene

Aliases for SLC35F2 Gene

  • Solute Carrier Family 35 Member F2 2 3 5
  • Lung Squamous Cell Cancer Related Protein LSCC-3 3
  • Solute Carrier Family 35, Member F2 2
  • HSNOV1 3

External Ids for SLC35F2 Gene

Previous GeneCards Identifiers for SLC35F2 Gene

  • GC11M107199
  • GC11M107166
  • GC11M107661
  • GC11M103587

Summaries for SLC35F2 Gene

GeneCards Summary for SLC35F2 Gene

SLC35F2 (Solute Carrier Family 35 Member F2) is a Protein Coding gene. An important paralog of this gene is SLC35F1.

UniProtKB/Swiss-Prot for SLC35F2 Gene

  • Putative solute transporter.

Additional gene information for SLC35F2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35F2 Gene

Genomics for SLC35F2 Gene

Regulatory Elements for SLC35F2 Gene

Enhancers for SLC35F2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H107839 1.3 Ensembl ENCODE 13.7 +86.5 86504 5 PKNOX1 ATF1 ARNT ZFP64 FEZF1 BRCA1 ZNF207 ATF7 FOS RUNX3 SLC35F2 LOC105369477 RPLP2P3 LOC203930
GH11H107856 1.1 ENCODE 14.9 +69.8 69761 4 HDGF PKNOX1 ATF1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 GTF3C2 NPAT SLC35F2 LOC105369477 DDX10 RPLP2P3 LOC203930
GH11H107927 1 ENCODE 6.7 -0.3 -291 1 PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 ATF7 KLF7 NPAT CWF19L2 CUL5 ALKBH8 DDX10 SLC35F2 ASS1P13 RAB39A
GH11H107695 1.2 Ensembl ENCODE dbSUPER 5.4 +231.9 231929 2 SMARCE1 JUN ZBTB40 EP300 RFX5 FOSL1 JUND SMARCA4 ZNF366 POLR2A SLN ALKBH8 ELMOD1 SLC35F2 ENSG00000254758
GH11H107849 0.4 ENCODE 14.6 +78.5 78544 1 RFX1 SLC35F2 RPLP2P3 LOC203930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35F2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35F2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000044491 -207 1401 PKNOX1 ATF1 SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ATF7 KLF7 FOS

Genomic Location for SLC35F2 Gene

Chromosome:
11
Start:
107,790,991 bp from pter
End:
107,928,293 bp from pter
Size:
137,303 bases
Orientation:
Minus strand

Genomic View for SLC35F2 Gene

Genes around SLC35F2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35F2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35F2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35F2 Gene

Proteins for SLC35F2 Gene

  • Protein details for SLC35F2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXU6-S35F2_HUMAN
    Recommended name:
    Solute carrier family 35 member F2
    Protein Accession:
    Q8IXU6
    Secondary Accessions:
    • Q14963
    • Q5JPA8
    • Q6ZRQ3
    • Q9H947

    Protein attributes for SLC35F2 Gene

    Size:
    374 amino acids
    Molecular mass:
    41212 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAA68226.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35F2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35F2 Gene

Post-translational modifications for SLC35F2 Gene

  • Ubiquitination at Lys33
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35F2 Gene

No data available for DME Specific Peptides for SLC35F2 Gene

Domains & Families for SLC35F2 Gene

Gene Families for SLC35F2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35F2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35F2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXU6

UniProtKB/Swiss-Prot:

S35F2_HUMAN :
  • Belongs to the SLC35F solute transporter family.
Family:
  • Belongs to the SLC35F solute transporter family.
genes like me logo Genes that share domains with SLC35F2: view

Function for SLC35F2 Gene

Molecular function for SLC35F2 Gene

UniProtKB/Swiss-Prot Function:
Putative solute transporter.

Phenotypes From GWAS Catalog for SLC35F2 Gene

Gene Ontology (GO) - Molecular Function for SLC35F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with SLC35F2: view
genes like me logo Genes that share phenotypes with SLC35F2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35F2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35F2 Gene

Localization for SLC35F2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35F2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35F2 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35F2: view

Pathways & Interactions for SLC35F2 Gene

SuperPathways for SLC35F2 Gene

No Data Available

Interacting Proteins for SLC35F2 Gene

Selected Interacting proteins: Q8IXU6-S35F2_HUMAN for SLC35F2 Gene via IID

Gene Ontology (GO) - Biological Process for SLC35F2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with SLC35F2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35F2 Gene

Drugs & Compounds for SLC35F2 Gene

No Compound Related Data Available

Transcripts for SLC35F2 Gene

Unigene Clusters for SLC35F2 Gene

Solute carrier family 35, member F2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35F2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35F2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3: -

Relevant External Links for SLC35F2 Gene

GeneLoc Exon Structure for
SLC35F2
ECgene alternative splicing isoforms for
SLC35F2

Expression for SLC35F2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35F2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35F2 Gene

This gene is overexpressed in Lung (40.1), Fetal ovary (15.8), and Placenta (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35F2 Gene



Protein tissue co-expression partners for SLC35F2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35F2 Gene:

SLC35F2

SOURCE GeneReport for Unigene cluster for SLC35F2 Gene:

Hs.524014

Evidence on tissue expression from TISSUES for SLC35F2 Gene

  • Intestine(4.1)
  • Lymph node(4.1)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with SLC35F2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35F2 Gene

Orthologs for SLC35F2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35F2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35F2 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 96 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToMany
-- 34
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC35F2 33 34
  • 88.86 (n)
mouse
(Mus musculus)
Mammalia Slc35f2 33 16 34
  • 85.12 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35F2 34
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35F2 33 34
  • 73.8 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35F2 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35f2 33
  • 68.36 (n)
Str.1493 33
zebrafish
(Danio rerio)
Actinopterygii slc35f2 33 34
  • 66.24 (n)
SLC35F2 (2 of 2) 34
  • 61 (a)
OneToMany
Dr.29116 33
worm
(Caenorhabditis elegans)
Secernentea Y73E7A.3 34
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for SLC35F2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35F2 Gene

ENSEMBL:
Gene Tree for SLC35F2 (if available)
TreeFam:
Gene Tree for SLC35F2 (if available)

Paralogs for SLC35F2 Gene

Paralogs for SLC35F2 Gene

(1) SIMAP similar genes for SLC35F2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC35F2: view

Variants for SLC35F2 Gene

Sequence variations from dbSNP and Humsavar for SLC35F2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000052974 -- 107,829,030(+) TTGAA(A/C)CTGGC intron-variant
rs1000085090 -- 107,829,371(+) CAGAG(A/G)TCGTG intron-variant
rs1000105795 -- 107,806,467(+) TTTTA(A/T)AGTAT intron-variant
rs1000117818 -- 107,859,811(+) GGATG(C/T)CCTGC upstream-variant-2KB
rs1000147972 -- 107,847,585(+) TATCA(C/T)CTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35F2 Gene

Variant ID Type Subtype PubMed ID
dgv1274n100 CNV gain 25217958
dgv1276n100 CNV gain 25217958
dgv1277n100 CNV gain 25217958
dgv2174n54 CNV gain 21841781
dgv2175n54 CNV loss 21841781
dgv2176n54 CNV gain 21841781
dgv22e203 CNV gain 21179565
dgv230e214 CNV gain 21293372
dgv414e212 CNV gain 25503493
esv23217 CNV gain 19812545
esv2421534 CNV duplication 20811451
esv2750980 CNV gain 17911159
esv3303907 CNV mobile element insertion 20981092
esv3404754 CNV insertion 20981092
esv3627655 CNV gain 21293372
esv3627658 CNV loss 21293372
esv3627659 CNV gain 21293372
esv3892099 CNV gain 25118596
nsv1035229 CNV gain 25217958
nsv1036874 CNV gain 25217958
nsv1043139 CNV gain 25217958
nsv1052198 CNV gain 25217958
nsv1143695 CNV deletion 24896259
nsv442244 CNV gain 18776908
nsv468867 CNV loss 19166990
nsv520229 CNV gain 19592680
nsv521771 CNV gain 19592680
nsv527748 CNV gain 19592680
nsv556380 CNV gain 21841781
nsv826079 CNV loss 20364138

Variation tolerance for SLC35F2 Gene

Residual Variation Intolerance Score: 87.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.98; 36.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35F2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35F2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35F2 Gene

Disorders for SLC35F2 Gene

Relevant External Links for SLC35F2

Genetic Association Database (GAD)
SLC35F2
Human Genome Epidemiology (HuGE) Navigator
SLC35F2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35F2

No disorders were found for SLC35F2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35F2 Gene

Publications for SLC35F2 Gene

  1. Construction of a transcription map around the gene for ataxia telangiectasia: identification of at least four novel genes. (PMID: 9119394) Stankovic T … Taylor AM (Genomics 1997) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for SLC35F2 Gene

Sources for SLC35F2 Gene

Content
Loading form....