SLC35E4 Gene
protein-coding GIFtS: 39
GCID: GC22P031031
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solute carrier family 35, member E4
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Aliases
for SLC35E4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member E41 2 | | Solute Carrier Family 35 Member E42 |
Export aliases for SLC35E4 gene to outside databasesPrevious GC identifers: GC22P029357 GC22P029347 GC22P029358 GC22P013994 |
Summaries
for SLC35E4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S35E4_HUMAN, Q6ICL7Function: Putative transporter (By similarity)
|
Genomic Views
for SLC35E4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC35E4 gene promoter:
Tal-1 AML1a SREBP-1c LCR-F1 SREBP-1b E47 CREB SREBP-1a TFIID
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35E4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q12.2 Ensembl cytogenetic band: 22q12.2 HGNC cytogenetic band: 22q12.2SLC35E4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P031031: view genomic region
(about GC identifiers)
Start:
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31,031,639 bp from pter |
End:
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31,065,003 bp from pter |
Size:
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33,365 bases |
Orientation:
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plus strand |
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Proteins
for SLC35E4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35E4_HUMAN, Q6ICL7 (See
protein sequence)Recommended Name: Solute carrier family 35 member E4 Size: 350 amino acids; 36747 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q567P0Alternative splicing: 2 isoforms: Q6ICL7-1 Q6ICL7-2 Explore the universe of human proteins at neXtProt for SLC35E4: NX_Q6ICL7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ICL7
SLC35E4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001479.1
ENSEMBL proteins: ENSP00000339626 ENSP00000384377 ENSP00000413552 ENSP00000300385
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
SLC35E4 for ontologies About GeneDecksing
SLC35E4 Antibody Products:
Assay Products for SLC35E4: |
Protein
Domains /
Families
for SLC35E4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35E4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ICL7ProtoNet protein and cluster: Q6ICL7 UniProtKB/Swiss-Prot: S35E4_HUMAN, Q6ICL7Similarity: Belongs to the TPT transporter family. SLC35E subfamilySimilarity: Contains 1 EamA domain |
Function
for SLC35E4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S35E4_HUMAN, Q6ICL7Function: Putative transporter (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC35E4 (NM_001001479) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35E4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E4 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E4 |
|
Pathways & Interactions
for SLC35E4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35E4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC35E4 (ENSP000003396264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for SLC35E4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35E4
Search CenterWatch for drugs/clinical trials and news about SLC35E4 / S35E4
|
Transcripts
for SLC35E4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35E4 gene: NM_001001479.2 Unigene Cluster for SLC35E4: Solute carrier family 35, member E4 Hs.660384 [show with all ESTs]Unigene Representative Sequence: BC0401914 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000343605(uc003ais.1) ENST00000406566 ENST00000451479(uc003ait.3)
ENST00000300385
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC35E4 (NM_001001479) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35E4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E4 |
Additional cDNA sequence: BC031973.1 BC040191.1 BC063569.1 BC093099.1 BC107119.2 CR456351.1 6 DOTS entries: DT.100771472 DT.109710 DT.97837467 DT.99951401 DT.95084062 DT.95373433 24/42 AceView cDNA sequences (see all 42): CA425705 CR614052 BG699772 BC040191 NM_001001479 AA643008 CR456351 BX281594 BX326836 BC063569 AA010644 BC031973 BM559764 BG332591 BI830603 BM479343 BF981528 BI825246 AA609257 F27442 BX369073 BF035708 CD557487 BU500423
GeneLoc Exon Structure
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Expression
for SLC35E4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35E4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAGGGAGGG
About this image
See SLC35E4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35E4
SOURCE GeneReport for Unigene cluster: Hs.660384
SABiosciences Custom PCR Arrays for SLC35E4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35E4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC35E4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35E4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35E4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E4 |
Orthologs
for SLC35E4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35E4 gene from 4/15 species (see all 15) About this table
ENSEMBL Gene Tree for SLC35E4 (if available)
TreeFam Gene Tree for SLC35E4 (if available) |
Paralogs
for SLC35E4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC35E4 gene
- SLC35E32
SLC35E4 for paralogs About GeneDecksing
|
Genomic Variants
for SLC35E4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35E4 (31031639 - 31065003 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC35E4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35E4 |
|
Disorders
/ Diseases
for SLC35E4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35E4 for disorders About GeneDecksing
1  disease for SLC35E4: About MalaCardsmalaria
Export disorders for SLC35E4 gene to outside databases
|
Publications
for SLC35E4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35E4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35E4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC35E4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC35E4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35E4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35E4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC35E4 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC35E4 gene:
Search GeneIP for patents involving SLC35E4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35E4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC35E4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC35E4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35E4 | | | OriGene Protein Over-expression Lysate for SLC35E4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC35E4 | | OriGene 3'-UTR Clone for SLC35E4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC35E4 | | OriGene Custom Protein Services for SLC35E4 | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35E4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35E4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35E4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35E4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35E4 |
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 |  |  |  | |
| | | | Search Tocris compounds for SLC35E4 |
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 | | | SLC35E4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E4 |
|  |  |  | | | | Search ThermoFisher Antibodies for SLC35E4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E4 |
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