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Aliases for SLC35E4 Gene

Aliases for SLC35E4 Gene

  • Solute Carrier Family 35, Member E4 2 3

External Ids for SLC35E4 Gene

Previous GeneCards Identifiers for SLC35E4 Gene

  • GC22P029357
  • GC22P029347
  • GC22P029358
  • GC22P031031
  • GC22P013994

Summaries for SLC35E4 Gene

GeneCards Summary for SLC35E4 Gene

SLC35E4 (Solute Carrier Family 35, Member E4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35E4 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E4 Gene

Genomics for SLC35E4 Gene

Regulatory Elements for SLC35E4 Gene

Genomic Location for SLC35E4 Gene

Start:
30,635,652 bp from pter
End:
30,669,016 bp from pter
Size:
33,365 bases
Orientation:
Plus strand

Genomic View for SLC35E4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35E4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E4 Gene

Proteins for SLC35E4 Gene

  • Protein details for SLC35E4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICL7-S35E4_HUMAN
    Recommended name:
    Solute carrier family 35 member E4
    Protein Accession:
    Q6ICL7
    Secondary Accessions:
    • Q567P0

    Protein attributes for SLC35E4 Gene

    Size:
    350 amino acids
    Molecular mass:
    36747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E4 Gene

Proteomics data for SLC35E4 Gene at MOPED

Post-translational modifications for SLC35E4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35E4 Gene

Domains for SLC35E4 Gene

Gene Families for SLC35E4 Gene

Protein Domains for SLC35E4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ICL7

UniProtKB/Swiss-Prot:

S35E4_HUMAN :
  • Q6ICL7
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E4: view

Function for SLC35E4 Gene

Molecular function for SLC35E4 Gene

UniProtKB/Swiss-Prot Function: Putative transporter.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC35E4 Gene

Localization for SLC35E4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35E4 Gene COMPARTMENTS Subcellular localization image for SLC35E4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC35E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E4: view

Pathways for SLC35E4 Gene

SuperPathways for SLC35E4 Gene

No Data Available

Interacting Proteins for SLC35E4 Gene

Gene Ontology (GO) - Biological Process for SLC35E4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC35E4: view

No data available for Pathways by source for SLC35E4 Gene

Transcripts for SLC35E4 Gene

mRNA/cDNA for SLC35E4 Gene

Unigene Clusters for SLC35E4 Gene

Solute carrier family 35, member E4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E4 Gene

No ASD Table

Relevant External Links for SLC35E4 Gene

GeneLoc Exon Structure for
SLC35E4
ECgene alternative splicing isoforms for
SLC35E4

Expression for SLC35E4 Gene

mRNA expression in normal human tissues for SLC35E4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC35E4 Gene

SOURCE GeneReport for Unigene cluster for SLC35E4 Gene Hs.660384

genes like me logo Genes that share expressions with SLC35E4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35E4 Gene

Orthologs for SLC35E4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E4 35
  • 98.29 (n)
  • 98.57 (a)
SLC35E4 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35E4 35
  • 86.67 (n)
  • 88.86 (a)
SLC35E4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35E4 35
  • 87.71 (n)
  • 89.43 (a)
SLC35E4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35e4 35
  • 82.86 (n)
  • 83.71 (a)
Slc35e4 16
Slc35e4 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35E4 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35e4 35
  • 82.38 (n)
  • 85.43 (a)
chicken
(Gallus gallus)
Aves SLC35E4 35
  • 73.58 (n)
  • 66.67 (a)
SLC35E4 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35E4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e4 35
  • 57.44 (n)
  • 53.75 (a)
zebrafish
(Danio rerio)
Actinopterygii slc35e4 35
  • 60.84 (n)
  • 54.69 (a)
slc35e4 36
  • 38 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os05g0121900 35
  • 46.03 (n)
  • 33.33 (a)
Species with no ortholog for SLC35E4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E4 Gene

ENSEMBL:
Gene Tree for SLC35E4 (if available)
TreeFam:
Gene Tree for SLC35E4 (if available)

Paralogs for SLC35E4 Gene

No data available for Paralogs for SLC35E4 Gene

Variants for SLC35E4 Gene

Sequence variations from dbSNP and Humsavar for SLC35E4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs734479 -- 30,647,497(+) TTGGA(A/G)TGGGG utr-variant-3-prime
rs1981590 -- 30,642,962(+) gaggc(A/G)gagct intron-variant
rs1981591 -- 30,643,932(+) CGAAT(C/G)GCTGC intron-variant
rs1981592 -- 30,644,250(+) AACAT(C/T)GGAAT intron-variant
rs2013928 -- 30,647,130(+) TGGTG(A/G)CTCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35E4 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv834175 CNV Gain 17160897
nsv829172 CNV Gain 20364138
esv2675394 CNV Deletion 23128226

Relevant External Links for SLC35E4 Gene

HapMap Linkage Disequilibrium report
SLC35E4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E4 Gene

Disorders for SLC35E4 Gene

No disorders were found for SLC35E4 Gene.

No data available for UniProtKB/Swiss-Prot for SLC35E4 Gene

Publications for SLC35E4 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35E4 Gene

Sources for SLC35E4 Gene

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