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Aliases for SLC35E4 Gene

Aliases for SLC35E4 Gene

  • Solute Carrier Family 35 Member E4 2 3 5
  • Solute Carrier Family 35, Member E4 2

External Ids for SLC35E4 Gene

Previous GeneCards Identifiers for SLC35E4 Gene

  • GC22P029357
  • GC22P029347
  • GC22P029358
  • GC22P031031
  • GC22P013994

Summaries for SLC35E4 Gene

GeneCards Summary for SLC35E4 Gene

SLC35E4 (Solute Carrier Family 35 Member E4) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35E4 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E4 Gene

Genomics for SLC35E4 Gene

Regulatory Elements for SLC35E4 Gene

Promoters for SLC35E4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35E4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35E4 Gene

Chromosome:
22
Start:
30,635,652 bp from pter
End:
30,669,016 bp from pter
Size:
33,365 bases
Orientation:
Plus strand

Genomic View for SLC35E4 Gene

Genes around SLC35E4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E4 Gene

Proteins for SLC35E4 Gene

  • Protein details for SLC35E4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICL7-S35E4_HUMAN
    Recommended name:
    Solute carrier family 35 member E4
    Protein Accession:
    Q6ICL7
    Secondary Accessions:
    • Q567P0

    Protein attributes for SLC35E4 Gene

    Size:
    350 amino acids
    Molecular mass:
    36747 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E4 Gene

Proteomics data for SLC35E4 Gene at MOPED

Post-translational modifications for SLC35E4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35E4 Gene

Domains & Families for SLC35E4 Gene

Gene Families for SLC35E4 Gene

Protein Domains for SLC35E4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ICL7

UniProtKB/Swiss-Prot:

S35E4_HUMAN :
  • Contains 1 EamA domain.
  • Belongs to the TPT transporter family. SLC35E subfamily.
Domain:
  • Contains 1 EamA domain.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E4: view

Function for SLC35E4 Gene

Molecular function for SLC35E4 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.
genes like me logo Genes that share phenotypes with SLC35E4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E4 Gene

Localization for SLC35E4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35E4 Gene COMPARTMENTS Subcellular localization image for SLC35E4 gene
Compartment Confidence
plasma membrane 3
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for SLC35E4 Gene

Pathways & Interactions for SLC35E4 Gene

SuperPathways for SLC35E4 Gene

No Data Available

Interacting Proteins for SLC35E4 Gene

Gene Ontology (GO) - Biological Process for SLC35E4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35E4 Gene

Drugs & Compounds for SLC35E4 Gene

No Compound Related Data Available

Transcripts for SLC35E4 Gene

Unigene Clusters for SLC35E4 Gene

Solute carrier family 35, member E4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E4 Gene

No ASD Table

Relevant External Links for SLC35E4 Gene

GeneLoc Exon Structure for
SLC35E4
ECgene alternative splicing isoforms for
SLC35E4

Expression for SLC35E4 Gene

mRNA expression in normal human tissues for SLC35E4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35E4 Gene



SOURCE GeneReport for Unigene cluster for SLC35E4 Gene Hs.660384

genes like me logo Genes that share expression patterns with SLC35E4: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC35E4 Gene

Orthologs for SLC35E4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E4 36
  • 90 (a)
OneToOne
SLC35E4 35
  • 98.29 (n)
  • 98.57 (a)
cow
(Bos Taurus)
Mammalia SLC35E4 36
  • 89 (a)
OneToOne
SLC35E4 35
  • 86.67 (n)
  • 88.86 (a)
dog
(Canis familiaris)
Mammalia SLC35E4 35
  • 87.71 (n)
  • 89.43 (a)
SLC35E4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35e4 16
Slc35e4 36
  • 84 (a)
OneToOne
Slc35e4 35
  • 82.86 (n)
  • 83.71 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35E4 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35e4 35
  • 82.38 (n)
  • 85.43 (a)
chicken
(Gallus gallus)
Aves SLC35E4 35
  • 73.58 (n)
  • 66.67 (a)
SLC35E4 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35E4 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e4 35
  • 57.44 (n)
  • 53.75 (a)
zebrafish
(Danio rerio)
Actinopterygii slc35e4 36
  • 38 (a)
OneToOne
slc35e4 35
  • 60.84 (n)
  • 54.69 (a)
rice
(Oryza sativa)
Liliopsida Os05g0121900 35
  • 46.03 (n)
  • 33.33 (a)
Species with no ortholog for SLC35E4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E4 Gene

ENSEMBL:
Gene Tree for SLC35E4 (if available)
TreeFam:
Gene Tree for SLC35E4 (if available)

Paralogs for SLC35E4 Gene

No data available for Paralogs for SLC35E4 Gene

Variants for SLC35E4 Gene

Sequence variations from dbSNP and Humsavar for SLC35E4 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs2013928 -- 30,647,130(+) TGGTG(A/G)CTCAC utr-variant-3-prime
rs3179442 -- 30,647,779(+) TGCTG(A/G)GCTCC utr-variant-3-prime
rs2270013 -- 30,646,365(+) cttac(A/G)gaggt intron-variant
rs5749147 -- 30,634,031(+) ggtgg(C/T)gcacg upstream-variant-2KB
rs5753259 -- 30,634,541(+) CGTCC(C/T)GTGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC35E4 Gene

Variant ID Type Subtype PubMed ID
nsv829171 CNV Loss 20364138
nsv834175 CNV Gain 17160897
nsv829172 CNV Gain 20364138
esv2675394 CNV Deletion 23128226

Variation tolerance for SLC35E4 Gene

Residual Variation Intolerance Score: 41.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.31; 41.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35E4 Gene

HapMap Linkage Disequilibrium report
SLC35E4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E4 Gene

Disorders for SLC35E4 Gene

Relevant External Links for SLC35E4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35E4

No disorders were found for SLC35E4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E4 Gene

Publications for SLC35E4 Gene

  1. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35E4 Gene

Sources for SLC35E4 Gene

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