SLC35E3 Gene
protein-coding GIFtS : 41
GCID: GC12 P069139
solute carrier family 35, member E3
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Aliasesfor SLC35E3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Solute Carrier Family 35, Member E3 1 2 BLOV11 2 3 Bladder Cancer-Overexpressed Gene 1 Protein2 3 Bladder Cancer Overexpressed Protein2 Solute Carrier Family 35 Member E32 Solute Carrier Family 35, Member E22
Export aliases for SLC35E3 gene to outside databases Previous GC identifers: GC12P068856 GC12P067426 GC12P066190
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Summariesfor SLC35E3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: S35E3_HUMAN, Q7Z769 Function : Putative transporter (By similarity)
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Genomic Viewsfor SLC35E3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_029419.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC35E3 gene promoter: AhR ISGF-3 C/EBPbeta AML1a HOXA3 POU3F1 Arnt GATA-1 AREB6 ATF6 Other transcription factors Search SABiosciences Chromatin IP Primers for SLC35E3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q15 Ensembl cytogenetic band: 12q15 HGNC cytogenetic band: 12q15 SLC35E3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P069139: view genomic region
(about GC identifiers )
Start:
69,139,886 bp from pter
End:
69,187,744 bp from pter
Size:
47,859 bases
Orientation:
plus strand
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Proteinsfor SLC35E3 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: S35E3_HUMAN, Q7Z769 (See
protein sequence )Recommended Name: Solute carrier family 35 member E3 Size : 313 amino acids; 35066 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=AAF73127.1; Type=Frameshift; Positions=4, 16, 40;
Secondary accessions : A8K0T0 Q0P5Y5 Q9P0V1Explore the universe of human proteins at neXtProt for SLC35E3: NX_Q7Z769 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q7Z769 SLC35E3 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_061126.2 ENSEMBL proteins: ENSP00000381089 ENSP00000403769 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
SLC35E3 for ontologies About GeneDecksing SLC35E3 Antibody Products: Assay Products for SLC35E3:
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Protein
Domains / Familiesfor SLC35E3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
SLC35E3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q7Z769 ProtoNet protein and cluster: Q7Z769
UniProtKB/Swiss-Prot: S35E3_HUMAN, Q7Z769 Similarity : Belongs to the TPT transporter family. SLC35E subfamily
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Functionfor SLC35E3 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: S35E3_HUMAN, Q7Z769 Function : Putative transporter (By similarity)
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC35E3 (NM_018656 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35E3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC35E3
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E3
1 GenomeRNAi human phenotype for SLC35E3 :Animal Models: Mouse knock-out Slc35e3 tm1Lex for SLC35E3 1 MGI phenotypic allele for Slc35e3 (no phenotypes)
SLC35E3 for phenotypes About GeneDecksing
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Pathways & Interactionsfor SLC35E3 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35E3
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Drugs & Compoundsfor SLC35E3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for SLC35E3 Search CenterWatch for drugs/clinical trials and news about SLC35E3 / S35E3
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Transcriptsfor SLC35E3 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for SLC35E3 gene: NM_018656.2 Unigene Cluster for SLC35E3:
Solute carrier family 35, member E3 Hs.506011 [show with all ESTs ] Unigene Representative Sequence: NM_018656 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000398004 (uc001suh.3 ) ENST00000319429 ENST00000431174 ENST00000538043 ENST00000504589 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: SLC35E3 (NM_018656 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35E3 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC35E3
Additional cDNA sequence: AF148713.1 AK289645.1 AY358943.1 BC008412.1 BC021103.1 BC030504.2 BC049192.1
6 DOTS entries : DT.100765664 DT.40261819
DT.97827073 DT.40126242 DT.75171532 DT.102825864 24/103 AceView cDNA sequences (see all 103 ):
AA377278 BC008412 BG774439 BG338851 BC049192 CA420708 AI263150 BG337597 AI191665 AY358943 CD171966 AI281113 AL561597 BI850297 AI032904 BQ681007 BM048278 BM801770 BC021103 BQ690056 BE909961 BC030504 BX370732 CA307935 GeneLoc Exon Structure
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Expression for SLC35E3 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section SLC35E3 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGTATATATA
About this image SLC35E3 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See SLC35E3 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC35E3 SOURCE GeneReport for Unigene cluster: Hs.506011 SABiosciences Custom PCR Arrays for SLC35E3 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC35E3Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat SLC35E3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC35E3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC35E3 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E3
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Orthologsfor SLC35E3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35E3 gene from 6/20 species (see all 20 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
SLC35E31
solute carrier family 35, member E3
76.63(n) 83.06(a)
 
417842 NM_001199616.1 NP_001186545.1
lizard (Anolis carolinensis)
Reptilia
SLC35E36
--
78(a)
1 ↔ 1
GL343256.1(1414590-1429194)
African clawed frog (Xenopus laevis)
Amphibia
Xl.84182
Xenopus laevis transcribed sequence with moderate similarity more
75.86(n)
 
AW158131.1
zebrafish (Danio rerio)
Actinopterygii
slc35e31
solute carrier family 35, member E3
72.52(n) 81.79(a)
 
563675 NM_001030179.1 NP_001025350.1
thale cress (Arabidopsis thaliana)
eudicotyledons
AT2G283151
nucleotide/sugar transporter-like protein
44.13(n) 34.51(a)
 
817378 NM_179789.3 NP_850120.3
rice (Oryza sativa)
Liliopsida
Os02g06282001
hypothetical protein
45.9(n) 35.02(a)
 
4330044 NM_001054022.1 NP_001047487.1
ENSEMBL Gene Tree for SLC35E3 (if available)TreeFam Gene Tree for SLC35E3 (if available)
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Paralogsfor SLC35E3 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for SLC35E3 gene SLC35E4 2 18/59 SIMAP similar genes for SLC35E3 using alignment to 2 protein entries: S35E3_HUMAN (see all proteins )
(see all similar genes ):IRF2 NELFA TAF2 RAD51 pp12301 ADCK1 ARL6IP5 CDK10 RRM2B ATF1 DNAPTP3 DYNC2LI1 OK/SW-cl.41 SEC14L3 NCKAP1L PFKFB3 FP6778 PKN1
SLC35E3 for paralogs About GeneDecksing 1 Pseudogenes.org Pseudogene for SLC35E3 PGOHUM00000244433
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Genomic Variantsfor SLC35E3 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for SLC35E3 (69139886 - 69187744 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC35E3: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC35E3
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Disorders
/ Diseasesfor SLC35E3 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
SLC35E3 for disorders About GeneDecksing 1 disease for SLC35E3 : About MalaCards malaria Export disorders for SLC35E3 gene to outside databases
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Publicationsfor SLC35E3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for SLC35E3 gene integrated from 9 sources : (articles sorted by number of sources associating them with SLC35E3) Utopia : connect your pdf to the dynamic world of online information
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 1 , 2 , 3 Clark H.F.... Gray A.M. (2003) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for SLC35E3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing SLC35E3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing SLC35E3 gene
(According to HUGE )
About This Section --
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Specialized Databases showing SLC35E3 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for SLC35E3 gene: Search GeneIP for patents involving SLC35E3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor SLC35E3 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies Browse OriGene shRNA RFPs OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for SLC35E3 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for SLC35E3 OriGene Protein Over-expression Lysate for SLC35E3 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for SLC35E3 OriGene 3'-UTR Clone for SLC35E3 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for SLC35E3 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for SLC35E3 OriGene Custom Protein Services for SLC35E3 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35E3 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing SLC35E3 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E3 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat SLC35E3 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat SLC35E3 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat SLC35E3
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SLC35E3 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E3
Search ThermoFisher Antibodies for SLC35E3
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat SLC35E3
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Aliases for SLC35E3
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Disorders / Diseases for SLC35E3
Domains / Families for SLC35E3
Drugs / Compounds for SLC35E3
Expression for SLC35E3
Function for SLC35E3
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Orthologs for SLC35E3
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Transcripts for SLC35E3
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