Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC35E3 Gene

Aliases for SLC35E3 Gene

  • Solute Carrier Family 35 Member E3 2 3 5
  • Bladder Cancer-Overexpressed Gene 1 Protein 3 4
  • BLOV1 3 4
  • Solute Carrier Family 35, Member E2 3
  • Solute Carrier Family 35, Member E3 2

External Ids for SLC35E3 Gene

Previous GeneCards Identifiers for SLC35E3 Gene

  • GC12P068856
  • GC12P067426
  • GC12P069139
  • GC12P066190

Summaries for SLC35E3 Gene

GeneCards Summary for SLC35E3 Gene

SLC35E3 (Solute Carrier Family 35 Member E3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for SLC35E3 Gene

  • Putative transporter.

Additional gene information for SLC35E3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E3 Gene

Genomics for SLC35E3 Gene

Regulatory Elements for SLC35E3 Gene

Enhancers for SLC35E3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H068783 1.6 FANTOM5 Ensembl ENCODE 12.1 +40.3 40318 5 FOXA2 ATF1 ARID4B FEZF1 DMAP1 YY1 TCF12 SLC30A9 ATF7 SP5 MDM2 RAP1B CPM SLC35E3 LOC100130075 LOC105369820
GH12H069023 1.3 FANTOM5 Ensembl ENCODE 6.8 +278.7 278663 1 GTF2F1 TBP MXI1 JUN MAX BRCA1 RAD21 RFX5 YY1 POLR2A CPSF6 MDM2 YEATS4 FRS2 NUP107 SLC35E3 GC12M069009 GC12M069139
GH12H068812 0.7 ENCODE 12.3 +66.6 66550 1 MAFG ZMYM3 DPF2 ZNF664 TCF12 ZNF316 GATA2 HMBOX1 NFE2 EMSY SLC35E3 MDM2 LOC100130075 ENSG00000256325
GH12H068674 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.5 -70.0 -70043 2 HDGF PKNOX1 INSM2 NFXL1 ZNF2 ZNF366 SCRT2 FOS ATF7 SP3 CPSF6 C1GALT1P1 MDM1 MDM2 NUP107 RAP1B SLC35E3 RPL7P42 GC12P068661
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35E3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35E3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000053658 694 2401 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF143

Genomic Location for SLC35E3 Gene

68,746,106 bp from pter
68,793,964 bp from pter
47,859 bases
Plus strand

Genomic View for SLC35E3 Gene

Genes around SLC35E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E3 Gene

Proteins for SLC35E3 Gene

  • Protein details for SLC35E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member E3
    Protein Accession:
    Secondary Accessions:
    • A8K0T0
    • Q0P5Y5
    • Q9P0V1

    Protein attributes for SLC35E3 Gene

    313 amino acids
    Molecular mass:
    35066 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAF73127.1; Type=Frameshift; Positions=4, 16, 40; Evidence={ECO:0000305};

neXtProt entry for SLC35E3 Gene

Post-translational modifications for SLC35E3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E3 Gene

No data available for DME Specific Peptides for SLC35E3 Gene

Domains & Families for SLC35E3 Gene

Gene Families for SLC35E3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for SLC35E3 Gene


Suggested Antigen Peptide Sequences for SLC35E3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35E subfamily.
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E3: view

Function for SLC35E3 Gene

Molecular function for SLC35E3 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.
genes like me logo Genes that share phenotypes with SLC35E3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35E3

CRISPR Products

miRNA for SLC35E3 Gene

miRTarBase miRNAs that target SLC35E3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35E3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E3 Gene

Localization for SLC35E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC35E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC35E3 Gene

Pathways & Interactions for SLC35E3 Gene

SuperPathways for SLC35E3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35E3 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35E3 Gene

Drugs & Compounds for SLC35E3 Gene

No Compound Related Data Available

Transcripts for SLC35E3 Gene

Unigene Clusters for SLC35E3 Gene

Solute carrier family 35, member E3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35E3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E3 Gene

No ASD Table

Relevant External Links for SLC35E3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35E3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35E3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E3 Gene

This gene is overexpressed in Retina (60.8) and Placenta (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35E3 Gene

Protein tissue co-expression partners for SLC35E3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35E3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35E3 Gene:


Evidence on tissue expression from TISSUES for SLC35E3 Gene

  • Nervous system(4.4)
  • Pancreas(4)
  • Heart(2.4)
  • Stomach(2.3)
genes like me logo Genes that share expression patterns with SLC35E3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E3 Gene

Orthologs for SLC35E3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35E3 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia SLC35E3 33 34
  • 92.44 (n)
(Canis familiaris)
Mammalia SLC35E3 33 34
  • 91.35 (n)
(Monodelphis domestica)
Mammalia SLC35E3 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Slc35e3 33
  • 89.88 (n)
(Mus musculus)
Mammalia Slc35e3 33 16 34
  • 89.46 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
-- 34
  • 65 (a)
(Gallus gallus)
Aves SLC35E3 33 34
  • 76.63 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8418 33
(Danio rerio)
Actinopterygii slc35e3 33 34
  • 72.52 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5791 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G28315 33
  • 43.2 (n)
(Oryza sativa)
Liliopsida Os02g0628200 33
  • 45.9 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
-- 34
  • 55 (a)
-- 34
  • 37 (a)
Species where no ortholog for SLC35E3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E3 Gene

Gene Tree for SLC35E3 (if available)
Gene Tree for SLC35E3 (if available)

Paralogs for SLC35E3 Gene

No data available for Paralogs for SLC35E3 Gene

Variants for SLC35E3 Gene

Sequence variations from dbSNP and Humsavar for SLC35E3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000116096 -- 68,748,035(+) TTTAT(C/G)AAGTG intron-variant, reference, missense
rs1000135395 -- 68,757,536(+) AGTTA(C/T)CTATA intron-variant
rs1000163438 -- 68,757,953(+) TGGGT(A/C/G)TGGTG intron-variant
rs1000210025 -- 68,753,384(+) GGAGG(A/T)CGAGG intron-variant
rs1000532240 -- 68,760,105(+) GAGGC(C/T)GAGGC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35E3 Gene

Variant ID Type Subtype PubMed ID
esv3629857 CNV loss 21293372
nsv522941 CNV gain 19592680
nsv759 CNV deletion 18451855

Variation tolerance for SLC35E3 Gene

Residual Variation Intolerance Score: 29.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35E3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E3 Gene

Disorders for SLC35E3 Gene

Relevant External Links for SLC35E3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35E3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E3 Gene

Publications for SLC35E3 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Identification of epigenetic interactions between miRNA and DNA methylation associated with gene expression as potential prognostic markers in bladder cancer. (PMID: 28589857) Shivakumar M … Kim D (BMC medical genomics 2017) 3 60
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 60
  4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y … Kamatani N (Nature genetics 2010) 3 60
  5. Comparative analyses of gene copy number and mRNA expression in glioblastoma multiforme tumors and xenografts. (PMID: 19139420) Hodgson JG … James CD (Neuro-oncology 2009) 3 60

Products for SLC35E3 Gene

Sources for SLC35E3 Gene

Loading form....