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Aliases for SLC35E2B Gene

Aliases for SLC35E2B Gene

  • Solute Carrier Family 35 Member E2B 2 3 5
  • Solute Carrier Family 35, Member E2B 2
  • KIAA0447 4
  • SLC35E2 3

External Ids for SLC35E2B Gene

Previous GeneCards Identifiers for SLC35E2B Gene

  • GC01M001595
  • GC01M000871
  • GC01M001596
  • GC01M001597
  • GC01M001600
  • GC01M001604
  • GC01M001609

Summaries for SLC35E2B Gene

GeneCards Summary for SLC35E2B Gene

SLC35E2B (Solute Carrier Family 35 Member E2B) is a Protein Coding gene. An important paralog of this gene is SLC35E2.

UniProtKB/Swiss-Prot for SLC35E2B Gene

  • Putative transporter.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E2B Gene

Genomics for SLC35E2B Gene

Regulatory Elements for SLC35E2B Gene

Enhancers for SLC35E2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G001624 1.5 Ensembl ENCODE dbSUPER 47 +61.1 61140 14.4 HDGF PKNOX1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF48 ZNF2 SLC30A9 SLC35E2B SLC35E2 LOC100288379 MIB2 LOC100129381 MORN1 LOC100287934 CICP3 LINC01786 LOC100129534
GH01G001658 1.3 ENCODE dbSUPER 50.9 +33.7 33660 1.8 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 KLF13 SLC35E2B LOC100129381 ENSG00000272004 PIR59394
GH01G001663 0.9 dbSUPER 55.9 +27.8 27768 2.6 ARNT SIN3A ZNF2 ZNF48 ZNF143 ZNF207 ZNF263 ZNF202 MCM3 ZNF592 SLC35E2B LOC100129381 LOC100288379 TMEM240 CCNL2 ENSG00000240731 ENSG00000272455 SLC35E2 LOC100129534 MORN1
GH01G001639 1.1 dbSUPER 45.4 +52.6 52603 1.7 HDGF CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 SLC35E2B LOC100129381 LOC100288379 NOC2L ENSG00000230092 ATAD3A PUSL1 CCNL2 LOC100288069 ENSG00000260179
GH01G001660 1.1 Ensembl ENCODE dbSUPER 39.4 +30.7 30703 2.6 KLF1 ZNF687 MNT ZNF48 POLR2A SMARCA4 ZNF600 ZBTB17 SUPT5H SLC35E2B LOC100129381 LOC100288379 SLC35E2 GC01P001660
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35E2B on UCSC Golden Path with GeneCards custom track

Promoters for SLC35E2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000000222 4 2401 CREB3L1 SIN3A ZNF2 ZNF143 ZNF207 SP3 REST SREBF1 ZNF610 SMARCA4

Genomic Location for SLC35E2B Gene

1,659,529 bp from pter
1,692,804 bp from pter
33,276 bases
Minus strand

Genomic View for SLC35E2B Gene

Genes around SLC35E2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E2B Gene

Proteins for SLC35E2B Gene

  • Protein details for SLC35E2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member E2B
    Protein Accession:
    Secondary Accessions:
    • B3KWR0
    • O75035
    • Q2TAY8
    • Q569F8
    • Q5CZA4
    • Q9Y3J8

    Protein attributes for SLC35E2B Gene

    405 amino acids
    Molecular mass:
    43777 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA32292.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for SLC35E2B Gene

Post-translational modifications for SLC35E2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E2B Gene

No data available for DME Specific Peptides for SLC35E2B Gene

Domains & Families for SLC35E2B Gene

Gene Families for SLC35E2B Gene

Protein Domains for SLC35E2B Gene


Suggested Antigen Peptide Sequences for SLC35E2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35E subfamily.
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E2B: view

Function for SLC35E2B Gene

Molecular function for SLC35E2B Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.
genes like me logo Genes that share phenotypes with SLC35E2B: view

Animal Model Products

CRISPR Products

miRNA for SLC35E2B Gene

miRTarBase miRNAs that target SLC35E2B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E2B Gene

Localization for SLC35E2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E2B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E2B gene
Compartment Confidence
plasma membrane 3
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC35E2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E2B: view

Pathways & Interactions for SLC35E2B Gene

SuperPathways for SLC35E2B Gene

No Data Available

Interacting Proteins for SLC35E2B Gene

Gene Ontology (GO) - Biological Process for SLC35E2B Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35E2B Gene

Drugs & Compounds for SLC35E2B Gene

No Compound Related Data Available

Transcripts for SLC35E2B Gene

mRNA/cDNA for SLC35E2B Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35E2B Gene

Solute carrier family 35, member E2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E2B Gene

No ASD Table

Relevant External Links for SLC35E2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35E2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35E2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E2B Gene

This gene is overexpressed in Heart (52.7) and Retina (16.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SLC35E2B Gene

Protein tissue co-expression partners for SLC35E2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35E2B Gene:


SOURCE GeneReport for Unigene cluster for SLC35E2B Gene:


Evidence on tissue expression from TISSUES for SLC35E2B Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with SLC35E2B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E2B Gene

Orthologs for SLC35E2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35E2B 35
  • 100 (a)
(Canis familiaris)
Mammalia SLC35E2B 34 35
  • 83.66 (n)
(Bos Taurus)
Mammalia SLC35E2B 35
  • 83 (a)
SLC35E2 34
  • 82.1 (n)
(Mus musculus)
Mammalia Slc35e2 34 16 35
  • 81.35 (n)
(Rattus norvegicus)
Mammalia Slc35e2b 34
  • 81.11 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35E2B 35
  • 78 (a)
(Monodelphis domestica)
Mammalia SLC35E2B 35
  • 76 (a)
(Gallus gallus)
Aves SLC35E2B 34 35
  • 73.83 (n)
(Anolis carolinensis)
Reptilia SLC35E2B 35
  • 81 (a)
(Danio rerio)
Actinopterygii LOC100331662 34
  • 71.43 (n)
SLC35E2B 35
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 35
  • 23 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G17630 34
  • 42.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for SLC35E2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E2B Gene

Gene Tree for SLC35E2B (if available)
Gene Tree for SLC35E2B (if available)

Paralogs for SLC35E2B Gene

Paralogs for SLC35E2B Gene

(2) SIMAP similar genes for SLC35E2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC35E2B: view

Variants for SLC35E2B Gene

Sequence variations from dbSNP and Humsavar for SLC35E2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000238116 -- 1,665,707(+) GGCCA(C/T)GGAGG nc-transcript-variant, utr-variant-3-prime
rs1000238748 -- 1,674,140(+) CTCAA(A/G)AAAGG intron-variant
rs1000247735 -- 1,670,546(+) CCTCC(C/T)CAGTA intron-variant
rs1000453965 -- 1,674,249(+) CAGGA(G/T)AATCG intron-variant
rs1000492129 -- 1,687,188(+) GCACG(-/CACA)CACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35E2B Gene

Variant ID Type Subtype PubMed ID
dgv16e59 CNV duplication 20981092
dgv2e199 CNV deletion 23128226
dgv37n54 CNV loss 21841781
dgv38n54 CNV gain 21841781
dgv39n54 CNV loss 21841781
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
esv1758309 CNV deletion 17803354
esv2677252 CNV deletion 23128226
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3551899 CNV deletion 23714750
esv3553010 CNV deletion 23714750
esv3575582 CNV gain 25503493
esv3577686 CNV loss 25503493
esv3585007 CNV loss 21293372
esv3585008 CNV loss 21293372
esv3585009 CNV gain 21293372
esv3585010 CNV loss 21293372
esv3585011 CNV loss 21293372
esv3585012 CNV gain 21293372
esv3891747 CNV loss 25118596
esv6099 CNV gain 19470904
nsv10161 CNV gain+loss 18304495
nsv1160797 CNV duplication 26073780
nsv482937 CNV loss 15286789
nsv545017 CNV loss 21841781
nsv545018 CNV loss 21841781
nsv545022 CNV loss 21841781
nsv545026 CNV loss 21841781
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv945745 CNV duplication 23825009
nsv947410 CNV duplication 23825009
nsv950516 CNV deletion 24416366

Variation tolerance for SLC35E2B Gene

Gene Damage Index Score: 1.83; 34.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35E2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E2B Gene

Disorders for SLC35E2B Gene

Relevant External Links for SLC35E2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35E2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E2B Gene

Publications for SLC35E2B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PMID: 9455484) Seki N. … Ohara O. (DNA Res. 1997) 3 4 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for SLC35E2B Gene

Sources for SLC35E2B Gene

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