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Aliases for SLC35E2 Gene

Aliases for SLC35E2 Gene

  • Solute Carrier Family 35 Member E2 2 3 5
  • Solute Carrier Family 35, Member E2 2

External Ids for SLC35E2 Gene

Previous GeneCards Identifiers for SLC35E2 Gene

  • GC01M9N0168
  • GC01M001695
  • GC01M001584
  • GC01M001587
  • GC01M001646
  • GC01M001654
  • GC01M000939

Summaries for SLC35E2 Gene

GeneCards Summary for SLC35E2 Gene

SLC35E2 (Solute Carrier Family 35 Member E2) is a Protein Coding gene. An important paralog of this gene is SLC35E2B.

UniProtKB/Swiss-Prot for SLC35E2 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E2 Gene

Genomics for SLC35E2 Gene

Regulatory Elements for SLC35E2 Gene

Enhancers for SLC35E2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F000983 1 Ensembl 35.5 +761.8 761776 0.8 ZFP64 RAD21 GLIS2 ZNF354C ZNF143 CREM ZNF654 ZNF680 CEBPB REST CCNL2 MIR6727 ENSG00000240731 LOC100288379 ENSG00000230092 FAM87B SLC35E2 LOC100129381 WASH7P LINC00115
GH01F001677 1.1 Ensembl ENCODE 33.3 +67.5 67516 2.4 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF121 ZNF766 ZNF143 KLF13 SLC35E2 LOC100129381 SLC35E2B ENSG00000272455 MMP23B MIR6727 ENSG00000272106 PIR58823 GC01M001675
GH01F002253 1.1 FANTOM5 Ensembl ENCODE 24.8 -511.9 -511897 9.4 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 FOS ZNF263 ENSG00000240731 CCNL2 MIR6727 SLC35E2 LOC100129381 SLC35E2B LOC100288379 MORN1 LINC01770 LOC100129534
GH01F001626 0.2 ENCODE 18.3 +116.3 116334 5.6 HDGF PKNOX1 SREBF2 SIN3A KLF17 EGR1 ZNF143 ZNF391 EGR2 HCFC1 SLC35E2B SLC35E2 LOC100288379 MIB2 MORN1 LOC100287934 CICP3 MIR6727 LINC01786 LOC100129534
GH01F001420 0.2 ENCODE 13.6 +323.8 323815 3.0 HDGF MLX ARID4B DMAP1 SLC30A9 KLF13 SP5 ZHX2 REST ZNF592 ANKRD65 ATAD3B SLC35E2 SLC35E2B LOC100129381 ENSG00000272455 MIR6727 TMEM88B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC35E2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35E2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001516784 99 3001 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 KLF13

Genomic Location for SLC35E2 Gene

Chromosome:
1
Start:
1,724,838 bp from pter
End:
1,745,999 bp from pter
Size:
21,162 bases
Orientation:
Minus strand

Genomic View for SLC35E2 Gene

Genes around SLC35E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E2 Gene

Proteins for SLC35E2 Gene

  • Protein details for SLC35E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CK97-S35E2_HUMAN
    Recommended name:
    Solute carrier family 35 member E2
    Protein Accession:
    P0CK97
    Secondary Accessions:
    • B3KWR0
    • O75035
    • Q2TAY8
    • Q569F8
    • Q5CZA4
    • Q5QPR8
    • Q9Y3J8

    Protein attributes for SLC35E2 Gene

    Size:
    266 amino acids
    Molecular mass:
    29079 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E2 Gene

Post-translational modifications for SLC35E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35E2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35E2 Gene

Domains & Families for SLC35E2 Gene

Gene Families for SLC35E2 Gene

Protein Domains for SLC35E2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CK97

UniProtKB/Swiss-Prot:

S35E2_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E2: view

Function for SLC35E2 Gene

Molecular function for SLC35E2 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes for SLC35E2 Gene

GenomeRNAi human phenotypes for SLC35E2:
genes like me logo Genes that share phenotypes with SLC35E2: view

Animal Model Products

miRNA for SLC35E2 Gene

miRTarBase miRNAs that target SLC35E2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E2 Gene

Localization for SLC35E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35E2 Gene COMPARTMENTS Subcellular localization image for SLC35E2 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Gene Ontology (GO) - Cellular Components for SLC35E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E2: view

Pathways & Interactions for SLC35E2 Gene

SuperPathways for SLC35E2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35E2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35E2 Gene

Transcripts for SLC35E2 Gene

mRNA/cDNA for SLC35E2 Gene

Unigene Clusters for SLC35E2 Gene

Solute carrier family 35, member E2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E2 Gene

No ASD Table

Relevant External Links for SLC35E2 Gene

GeneLoc Exon Structure for
SLC35E2
ECgene alternative splicing isoforms for
SLC35E2

Expression for SLC35E2 Gene

mRNA expression in normal human tissues for SLC35E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35E2 Gene:

SLC35E2

SOURCE GeneReport for Unigene cluster for SLC35E2 Gene:

Hs.707620
genes like me logo Genes that share expression patterns with SLC35E2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for SLC35E2 Gene

Orthologs for SLC35E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E2 34
  • 99.32 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35E2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e2b 34
  • 65.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 35
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 10 (a)
OneToMany
Species where no ortholog for SLC35E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC35E2 Gene

ENSEMBL:
Gene Tree for SLC35E2 (if available)
TreeFam:
Gene Tree for SLC35E2 (if available)

Paralogs for SLC35E2 Gene

Paralogs for SLC35E2 Gene

(1) SIMAP similar genes for SLC35E2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35E2: view

Variants for SLC35E2 Gene

Sequence variations from dbSNP and Humsavar for SLC35E2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1061881 -- 1,729,373(-) AATGC(C/T)CTGGA intron-variant, utr-variant-3-prime
rs1061883 -- 1,729,296(-) TCCCC(A/G)TCGAG intron-variant, utr-variant-3-prime
rs1061884 -- 1,729,287(-) AGAAT(A/G)TGGCT intron-variant, utr-variant-3-prime
rs1061885 -- 1,729,092(-) ATAGG(G/T)TGATT intron-variant, utr-variant-3-prime
rs1061886 -- 1,729,090(-) AGGTT(A/G)ATTTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35E2 Gene

Variant ID Type Subtype PubMed ID
dgv2e214 CNV loss 21293372
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv40n54 CNV loss 21841781
dgv41n54 CNV loss 21841781
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv2764265 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3567896 CNV gain 25503493
esv3585010 CNV loss 21293372
esv3585015 CNV gain 21293372
esv3891747 CNV loss 25118596
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1076312 CNV duplication 25765185
nsv1160797 CNV duplication 26073780
nsv1160864 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv436343 CNV deletion 17901297
nsv442858 CNV gain+loss 18776908
nsv482937 CNV loss 15286789
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545032 CNV loss 21841781
nsv545040 CNV loss 21841781
nsv822475 CNV gain 20364138
nsv822697 CNV loss 20364138
nsv822809 CNV loss 20364138
nsv834091 CNV loss 17160897
nsv945747 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for SLC35E2 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E2 Gene

Disorders for SLC35E2 Gene

Relevant External Links for SLC35E2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35E2

No disorders were found for SLC35E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E2 Gene

Publications for SLC35E2 Gene

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for SLC35E2 Gene

Sources for SLC35E2 Gene

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