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Aliases for SLC35E2 Gene

Aliases for SLC35E2 Gene

  • Solute Carrier Family 35 Member E2 2 3 5
  • Solute Carrier Family 35, Member E2 2

External Ids for SLC35E2 Gene

Previous GeneCards Identifiers for SLC35E2 Gene

  • GC01M9N0168
  • GC01M001695
  • GC01M001584
  • GC01M001587
  • GC01M001646
  • GC01M001654
  • GC01M000939

Summaries for SLC35E2 Gene

GeneCards Summary for SLC35E2 Gene

SLC35E2 (Solute Carrier Family 35 Member E2) is a Protein Coding gene. An important paralog of this gene is SLC35E2B.

UniProtKB/Swiss-Prot for SLC35E2 Gene

  • Putative transporter.

Additional gene information for SLC35E2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E2 Gene

Genomics for SLC35E2 Gene

GeneHancer (GH) Regulatory Elements for SLC35E2 Gene

Promoters and enhancers for SLC35E2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I001745 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 563 -0.1 -102 2.2 PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF766 E2F8 ZNF207 ZNF143 SLC35E2 LOC100288379 CCNL2 ENSG00000230092 RER1 SDF4 CDK11A INTS11 LOC100129381 MXRA8
GH01I002543 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 32.2 -801.1 -801087 7.5 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 SP3 NFYC MEF2D ENSG00000272449 GC01M002542 LOC100288379 CDK11A SLC35E2 LOC100129381 TNFRSF14 FAAP20 MMEL1 RER1
GH01I001397 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.9 +345.9 345885 5.5 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 CCNL2 LOC148413 INTS11 ATAD3B ENSG00000240731 LOC100288379 ENSG00000230092 CDK11A SLC35E2 LOC100129381
GH01I001356 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.2 +386.6 386628 6.5 HDGF ARNT ARID4B YBX1 DMAP1 ZNF2 FOS SP5 NFYC ZHX2 MXRA8 SLC35E2 LOC100129381 ANKRD65 CCNL2 LOC100288379 SDF4 ENSG00000272455 INTS11 ENSG00000240731
GH01I002226 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.8 -485.3 -485345 9.9 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SKI SLC35E2 ENSG00000272455 LOC100129381 ENSG00000234396 MORN1 FAAP20 ATAD3B INTS11 LOC100129534
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35E2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35E2 gene promoter:

Genomic Locations for SLC35E2 Gene

Genomic Locations for SLC35E2 Gene
chr1:1,724,838-1,745,999
(GRCh38/hg38)
Size:
21,162 bases
Orientation:
Minus strand
chr1:1,656,277-1,677,438
(GRCh37/hg19)

Genomic View for SLC35E2 Gene

Genes around SLC35E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E2 Gene

Proteins for SLC35E2 Gene

  • Protein details for SLC35E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CK97-S35E2_HUMAN
    Recommended name:
    Solute carrier family 35 member E2
    Protein Accession:
    P0CK97
    Secondary Accessions:
    • B3KWR0
    • O75035
    • Q2TAY8
    • Q569F8
    • Q5CZA4
    • Q5QPR8
    • Q9Y3J8

    Protein attributes for SLC35E2 Gene

    Size:
    266 amino acids
    Molecular mass:
    29079 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35E2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E2 Gene

Post-translational modifications for SLC35E2 Gene

No Post-translational modifications

Other Protein References for SLC35E2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35E2 Gene

Domains & Families for SLC35E2 Gene

Gene Families for SLC35E2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SLC35E2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CK97

UniProtKB/Swiss-Prot:

S35E2_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E2: view

Function for SLC35E2 Gene

Molecular function for SLC35E2 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.

Phenotypes From GWAS Catalog for SLC35E2 Gene

Phenotypes for SLC35E2 Gene

GenomeRNAi human phenotypes for SLC35E2:
genes like me logo Genes that share phenotypes with SLC35E2: view

Animal Model Products

CRISPR Products

miRNA for SLC35E2 Gene

miRTarBase miRNAs that target SLC35E2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E2 Gene

Localization for SLC35E2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35E2 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E2: view

Pathways & Interactions for SLC35E2 Gene

SuperPathways for SLC35E2 Gene

No Data Available

Interacting Proteins for SLC35E2 Gene

Gene Ontology (GO) - Biological Process for SLC35E2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35E2 Gene

Drugs & Compounds for SLC35E2 Gene

No Compound Related Data Available

Transcripts for SLC35E2 Gene

mRNA/cDNA for SLC35E2 Gene

Unigene Clusters for SLC35E2 Gene

Solute carrier family 35, member E2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E2 Gene

No ASD Table

Relevant External Links for SLC35E2 Gene

GeneLoc Exon Structure for
SLC35E2
ECgene alternative splicing isoforms for
SLC35E2

Expression for SLC35E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35E2 Gene:

SLC35E2

SOURCE GeneReport for Unigene cluster for SLC35E2 Gene:

Hs.707620

Evidence on tissue expression from TISSUES for SLC35E2 Gene

  • Nervous system(4.6)
  • Lung(2)
genes like me logo Genes that share expression patterns with SLC35E2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35E2 Gene

Orthologs for SLC35E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35E2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E2 33
  • 99.32 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35E2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e2b 33
  • 65.64 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 34
  • 10 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 10 (a)
OneToMany
Species where no ortholog for SLC35E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SLC35E2 Gene

ENSEMBL:
Gene Tree for SLC35E2 (if available)
TreeFam:
Gene Tree for SLC35E2 (if available)

Paralogs for SLC35E2 Gene

Paralogs for SLC35E2 Gene

(1) SIMAP similar genes for SLC35E2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC35E2: view

Variants for SLC35E2 Gene

Sequence variations from dbSNP and Humsavar for SLC35E2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000046724 -- 1,735,466(-) C/G intron_variant
rs1000150952 -- 1,735,314(-) C/A intron_variant
rs1000390889 -- 1,728,486(-) A/C 3_prime_UTR_variant, intron_variant
rs1000554637 -- 1,740,398(-) T/A intron_variant
rs1000981370 -- 1,726,823(-) T/A/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35E2 Gene

Variant ID Type Subtype PubMed ID
dgv2e214 CNV loss 21293372
dgv3e212 CNV loss 25503493
dgv3n67 CNV gain 20364138
dgv40n54 CNV loss 21841781
dgv41n54 CNV loss 21841781
dgv42n54 CNV loss 21841781
dgv4e212 CNV gain 25503493
dgv5e212 CNV gain 25503493
dgv5n111 CNV deletion 26073780
dgv8n100 CNV loss 25217958
dgv9n100 CNV loss 25217958
esv2758913 CNV gain+loss 17122850
esv2760410 CNV gain+loss 21179565
esv2764265 CNV gain+loss 21179565
esv27786 CNV gain 19812545
esv3550788 CNV deletion 23714750
esv3567896 CNV gain 25503493
esv3585010 CNV loss 21293372
esv3585015 CNV gain 21293372
esv3891747 CNV loss 25118596
nsv1003545 CNV gain+loss 25217958
nsv1011683 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1076312 CNV duplication 25765185
nsv1160797 CNV duplication 26073780
nsv1160864 CNV duplication 26073780
nsv1160925 CNV deletion 26073780
nsv436343 CNV deletion 17901297
nsv442858 CNV gain+loss 18776908
nsv482937 CNV loss 15286789
nsv545027 CNV loss 21841781
nsv545030 CNV gain 21841781
nsv545031 CNV gain 21841781
nsv545032 CNV loss 21841781
nsv545040 CNV loss 21841781
nsv822475 CNV gain 20364138
nsv822697 CNV loss 20364138
nsv822809 CNV loss 20364138
nsv834091 CNV loss 17160897
nsv945747 CNV duplication 23825009
nsv950521 CNV deletion 24416366

Variation tolerance for SLC35E2 Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35E2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E2 Gene

Disorders for SLC35E2 Gene

Additional Disease Information for SLC35E2

No disorders were found for SLC35E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E2 Gene

Publications for SLC35E2 Gene

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for SLC35E2 Gene

Sources for SLC35E2 Gene

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