SLC35E2 Gene
protein-coding GIFtS: 44
GCID: GC01M001654
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solute carrier family 35, member E2
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Aliases
for SLC35E2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member E21 2 | | KIAA04471 | | Solute Carrier Family 35 Member E22 |
Export aliases for SLC35E2 gene to outside databasesPrevious GC identifers: GC01M9N0168 GC01M001695 GC01M001584 GC01M001587 GC01M001646 GC01M000939 |
Summaries
for SLC35E2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: S35E2_HUMAN, P0CK97Function: Putative transporter (By similarity)
|
Genomic Views
for SLC35E2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004350.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC35E2 gene promoter:
CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35E2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33SLC35E2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M001654: view genomic region
(about GC identifiers)
Start:
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1,656,277 bp from pter |
End:
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1,677,431 bp from pter |
Size:
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21,155 bases |
Orientation:
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minus strand |
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Proteins
for SLC35E2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35E2_HUMAN, P0CK97 (See
protein sequence)Recommended Name: Solute carrier family 35 member E2 Size: 266 amino acids; 29079 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B3KWR0 O75035 Q2TAY8 Q569F8 Q5CZA4 Q5QPR8 Q9Y3J8Alternative splicing: 2 isoforms: P0CK97-1 P0CK97-2 Explore the universe of human proteins at neXtProt for SLC35E2: NX_P0CK97
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CK97
SLC35E2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186716.1 NP_878258.1
ENSEMBL proteins: ENSP00000347614 ENSP00000246421 ENSP00000383714
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
SLC35E2 for ontologies About GeneDecksing
SLC35E2 Antibody Products:
Assay Products for SLC35E2: |
Protein
Domains /
Families
for SLC35E2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35E2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P0CK97ProtoNet protein and cluster: P0CK97 UniProtKB/Swiss-Prot: S35E2_HUMAN, P0CK97Similarity: Belongs to the TPT transporter family. SLC35E subfamily |
Function
for SLC35E2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: S35E2_HUMAN, P0CK97Function: Putative transporter (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for SLC35E2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E2 |
|
Pathways & Interactions
for SLC35E2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35E2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for SLC35E2 (ENSP000002464214) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for SLC35E2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35E2
Search CenterWatch for drugs/clinical trials and news about SLC35E2 / S35E2
|
Transcripts
for SLC35E2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35E2 gene (2 alternative transcripts): NM_001199787.1 NM_182838.2 Unigene Clusters for SLC35E2: Solute carrier family 35, member E2 Hs.707620 [show with all ESTs], Hs.736504 [show with all ESTs], Hs.744616 [show with all ESTs]Unigene Representative Sequences: NM_182838, AL519810, AK1265014 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000355439(uc001ahy.3) ENST00000246421(uc001aia.2) ENST00000475229
ENST00000400924
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC35E2 (NM_182838) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35E2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E2 |
Additional cDNA sequence: AK126501.1 BC073900.1 15 DOTS entries: DT.99990129 DT.100727699 DT.218727 DT.99930442 DT.100027303 DT.100734894 DT.75101469 DT.95224393 DT.100819769 DT.100728380 DT.121399141 DT.442446 DT.95253813 DT.97775217 DT.97823659 24/499 AceView cDNA sequences (see all 499): BQ717326 BQ045355 AA159745 AI066775 CB161273 C02016 CB159795 CA434883 AI263381 F02917 BM977699 BE502848 T23728 BX646365 BE328002 AA761922 AA706409 AL519809 BM679566 CR600892 BC014464 AL043340 BE674770 AI262667
GeneLoc Exon Structure
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Expression
for SLC35E2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35E2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC35E2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35E2
SOURCE GeneReport for Unigene clusters: Hs.707620 Hs.736504 Hs.744616
SABiosciences Custom PCR Arrays for SLC35E2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35E2
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat SLC35E2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35E2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35E2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E2 |
Orthologs
for SLC35E2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35E2 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for SLC35E2 (if available)
TreeFam Gene Tree for SLC35E2 (if available) |
Paralogs
for SLC35E2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC35E2 gene
- SLC35E12 SLC35E2B2
1 SIMAP similar gene for SLC35E2 using alignment to 1 protein entry: S35E2_HUMAN:SLC35E2B
SLC35E2 for paralogs About GeneDecksing
|
Genomic Variants
for SLC35E2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35E2 (1656277 - 1677431 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for SLC35E2
9 CNVs: 22925 38832 2295 30362 3276 0002 31596 63709 84001 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35E2 |
|
Disorders
/ Diseases
for SLC35E2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35E2 for disorders About GeneDecksing
1  disease for SLC35E2: About MalaCardsmalaria
Export disorders for SLC35E2 gene to outside databases
|
Publications
for SLC35E2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35E2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35E2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1 Seki N.... Ohara O. (1997)
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External Searches for SLC35E2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing SLC35E2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35E2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing SLC35E2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for SLC35E2 gene:
Search GeneIP for patents involving SLC35E2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35E2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC35E2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC35E2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35E2 | | | OriGene Protein Over-expression Lysate for SLC35E2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC35E2 | | OriGene 3'-UTR Clone for SLC35E2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35E2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35E2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35E2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35E2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35E2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35E2 |
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| | | | Search Tocris compounds for SLC35E2 |
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 | | | SLC35E2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35E2 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35E2 |
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