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Aliases for SLC35E1 Gene

Aliases for SLC35E1 Gene

  • Solute Carrier Family 35, Member E1 2 3

External Ids for SLC35E1 Gene

Previous GeneCards Identifiers for SLC35E1 Gene

  • GC19M016507
  • GC19M016523
  • GC19M016522
  • GC19M016660
  • GC19M016229

Summaries for SLC35E1 Gene

GeneCards Summary for SLC35E1 Gene

SLC35E1 (Solute Carrier Family 35, Member E1) is a Protein Coding gene. An important paralog of this gene is SLC35E2.

UniProtKB/Swiss-Prot for SLC35E1 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E1 Gene

Genomics for SLC35E1 Gene

Regulatory Elements for SLC35E1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC35E1 Gene

Start:
16,549,831 bp from pter
End:
16,572,382 bp from pter
Size:
22,552 bases
Orientation:
Minus strand

Genomic View for SLC35E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E1 Gene

Proteins for SLC35E1 Gene

  • Protein details for SLC35E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K37-S35E1_HUMAN
    Recommended name:
    Solute carrier family 35 member E1
    Protein Accession:
    Q96K37
    Secondary Accessions:
    • Q8NBQ2
    • Q96JV7

    Protein attributes for SLC35E1 Gene

    Size:
    410 amino acids
    Molecular mass:
    44773 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14557.1; Type=Frameshift; Positions=372, 384; Evidence={ECO:0000305}; Sequence=AAH62562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55306.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55410.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E1 Gene

Proteomics data for SLC35E1 Gene at MOPED

Post-translational modifications for SLC35E1 Gene

  • Ubiquitination at Lys345, Lys358, and Lys367
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35E1 Gene

No data available for DME Specific Peptides for SLC35E1 Gene

Domains for SLC35E1 Gene

Gene Families for SLC35E1 Gene

Protein Domains for SLC35E1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K37

UniProtKB/Swiss-Prot:

S35E1_HUMAN :
  • Q96K37
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E1: view

Function for SLC35E1 Gene

Molecular function for SLC35E1 Gene

UniProtKB/Swiss-Prot Function: Putative transporter.

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35E1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC35E1 Gene

Localization for SLC35E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35E1 Gene COMPARTMENTS Subcellular localization image for SLC35E1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC35E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35E1: view

Pathways for SLC35E1 Gene

SuperPathways for SLC35E1 Gene

No Data Available

Interacting Proteins for SLC35E1 Gene

Gene Ontology (GO) - Biological Process for SLC35E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0055085 transmembrane transport --
genes like me logo Genes that share ontologies with SLC35E1: view

No data available for Pathways by source for SLC35E1 Gene

Transcripts for SLC35E1 Gene

Unigene Clusters for SLC35E1 Gene

Solute carrier family 35, member E1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35E1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for SLC35E1 Gene

GeneLoc Exon Structure for
SLC35E1
ECgene alternative splicing isoforms for
SLC35E1

Expression for SLC35E1 Gene

mRNA expression in normal human tissues for SLC35E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35E1 Gene

SOURCE GeneReport for Unigene cluster for SLC35E1 Gene Hs.620596

genes like me logo Genes that share expressions with SLC35E1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35E1 Gene

Orthologs for SLC35E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35E1 35
  • 99.82 (n)
  • 100 (a)
SLC35E1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35E1 35
  • 90.66 (n)
  • 96.34 (a)
SLC35E1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35E1 35
  • 92.5 (n)
  • 97.12 (a)
SLC35E1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35e1 35
  • 86.67 (n)
  • 92.99 (a)
Slc35e1 16
Slc35e1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35E1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35E1 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35e1 35
  • 85.63 (n)
  • 92.99 (a)
chicken
(Gallus gallus)
Aves SLC35E1 35
  • 77.78 (n)
  • 84.95 (a)
SLC35E1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35E1 36
  • 57 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11369 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e1 35
  • 74.13 (n)
  • 80.6 (a)
Str.215 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3762 35
slc35e1 35
  • 70.51 (n)
  • 72.53 (a)
slc35e1 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000544 35
  • 58.28 (n)
  • 53.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 35
  • 57.08 (n)
  • 50.31 (a)
CG14621 36
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR543C 35
  • 47.49 (n)
  • 27.76 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLY41 35
  • 38.65 (n)
  • 28.34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08569g 35
  • 40.44 (n)
  • 29.51 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GPT1 35
  • 47.17 (n)
  • 37.91 (a)
rice
(Oryza sativa)
Liliopsida Os08g0187800 35
  • 45.62 (n)
  • 36.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05453 35
  • 47.62 (n)
  • 34.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC83.11 35
  • 40.14 (n)
  • 34.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC35E1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E1 Gene

ENSEMBL:
Gene Tree for SLC35E1 (if available)
TreeFam:
Gene Tree for SLC35E1 (if available)

Paralogs for SLC35E1 Gene

Paralogs for SLC35E1 Gene

Selected SIMAP similar genes for SLC35E1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC35E1 Gene

genes like me logo Genes that share paralogs with SLC35E1: view

Variants for SLC35E1 Gene

Sequence variations from dbSNP and Humsavar for SLC35E1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs251671 -- 16,568,565(-) cgaca(C/G)agcga intron-variant
rs731617 -- 16,555,046(+) AAGCT(C/T)TGACA intron-variant
rs1559201 -- 16,566,478(-) AATAG(G/T)TGCTT intron-variant
rs1559202 -- 16,564,135(-) GGAGC(A/G)GTATT intron-variant
rs1985857 -- 16,553,453(+) GCATG(A/G)GACAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35E1 Gene

Variant ID Type Subtype PubMed ID
nsv911167 CNV Loss 21882294
nsv510757 CNV Loss 20534489

Relevant External Links for SLC35E1 Gene

HapMap Linkage Disequilibrium report
SLC35E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E1 Gene

Disorders for SLC35E1 Gene

No disorders were found for SLC35E1 Gene.

No data available for UniProtKB/Swiss-Prot for SLC35E1 Gene

Publications for SLC35E1 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35E1 Gene

Sources for SLC35E1 Gene

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