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Aliases for SLC35E1 Gene

Aliases for SLC35E1 Gene

  • Solute Carrier Family 35 Member E1 2 3 5
  • Solute Carrier Family 35, Member E1 2

External Ids for SLC35E1 Gene

Previous GeneCards Identifiers for SLC35E1 Gene

  • GC19M016507
  • GC19M016523
  • GC19M016522
  • GC19M016660
  • GC19M016229

Summaries for SLC35E1 Gene

GeneCards Summary for SLC35E1 Gene

SLC35E1 (Solute Carrier Family 35 Member E1) is a Protein Coding gene. An important paralog of this gene is SLC35E2B.

UniProtKB/Swiss-Prot for SLC35E1 Gene

  • Putative transporter.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35E1 Gene

Genomics for SLC35E1 Gene

Regulatory Elements for SLC35E1 Gene

Enhancers for SLC35E1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35E1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35E1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35E1 Gene

Chromosome:
19
Start:
16,549,831 bp from pter
End:
16,572,382 bp from pter
Size:
22,552 bases
Orientation:
Minus strand

Genomic View for SLC35E1 Gene

Genes around SLC35E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35E1 Gene

Proteins for SLC35E1 Gene

  • Protein details for SLC35E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96K37-S35E1_HUMAN
    Recommended name:
    Solute carrier family 35 member E1
    Protein Accession:
    Q96K37
    Secondary Accessions:
    • Q8NBQ2
    • Q96JV7

    Protein attributes for SLC35E1 Gene

    Size:
    410 amino acids
    Molecular mass:
    44773 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14557.1; Type=Frameshift; Positions=372, 384; Evidence={ECO:0000305}; Sequence=AAH62562.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55306.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55410.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11565.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35E1 Gene

Proteomics data for SLC35E1 Gene at MOPED

Post-translational modifications for SLC35E1 Gene

  • Ubiquitination at Lys 345, Lys 358, and Lys 367
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35E1 Gene

No data available for DME Specific Peptides for SLC35E1 Gene

Domains & Families for SLC35E1 Gene

Gene Families for SLC35E1 Gene

Protein Domains for SLC35E1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35E1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96K37

UniProtKB/Swiss-Prot:

S35E1_HUMAN :
  • Belongs to the TPT transporter family. SLC35E subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35E subfamily.
genes like me logo Genes that share domains with SLC35E1: view

Function for SLC35E1 Gene

Molecular function for SLC35E1 Gene

UniProtKB/Swiss-Prot Function:
Putative transporter.
genes like me logo Genes that share phenotypes with SLC35E1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35E1

CRISPR Products

miRNA for SLC35E1 Gene

miRTarBase miRNAs that target SLC35E1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35E1 Gene

Localization for SLC35E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35E1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35E1 Gene COMPARTMENTS Subcellular localization image for SLC35E1 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for SLC35E1 Gene

Pathways & Interactions for SLC35E1 Gene

SuperPathways for SLC35E1 Gene

No Data Available

Interacting Proteins for SLC35E1 Gene

Gene Ontology (GO) - Biological Process for SLC35E1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35E1 Gene

Drugs & Compounds for SLC35E1 Gene

No Compound Related Data Available

Transcripts for SLC35E1 Gene

Unigene Clusters for SLC35E1 Gene

Solute carrier family 35, member E1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - - -

Relevant External Links for SLC35E1 Gene

GeneLoc Exon Structure for
SLC35E1
ECgene alternative splicing isoforms for
SLC35E1

Expression for SLC35E1 Gene

mRNA expression in normal human tissues for SLC35E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35E1 Gene

This gene is overexpressed in Placenta (13.3), Breast (7.3), and Monocytes (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35E1 Gene



SOURCE GeneReport for Unigene cluster for SLC35E1 Gene Hs.620596

genes like me logo Genes that share expression patterns with SLC35E1: view

Protein tissue co-expression partners for SLC35E1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35E1 Gene

Orthologs for SLC35E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35E1 35
  • 90.66 (n)
  • 96.34 (a)
SLC35E1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35E1 35
  • 92.5 (n)
  • 97.12 (a)
SLC35E1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35e1 35
  • 86.67 (n)
  • 92.99 (a)
Slc35e1 16
Slc35e1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35E1 35
  • 99.82 (n)
  • 100 (a)
SLC35E1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35e1 35
  • 85.63 (n)
  • 92.99 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35E1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35E1 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35E1 35
  • 77.78 (n)
  • 84.95 (a)
SLC35E1 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35E1 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35e1 35
  • 74.13 (n)
  • 80.6 (a)
Str.215 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11369 35
zebrafish
(Danio rerio)
Actinopterygii Dr.3762 35
slc35e1 35
  • 70.51 (n)
  • 72.53 (a)
slc35e1 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000544 35
  • 58.28 (n)
  • 53.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14621 35
  • 57.08 (n)
  • 50.31 (a)
CG14621 36
  • 43 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR543C 35
  • 47.49 (n)
  • 27.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08569g 35
  • 40.44 (n)
  • 29.51 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SLY41 35
  • 38.65 (n)
  • 28.34 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons GPT1 35
  • 47.17 (n)
  • 37.91 (a)
rice
(Oryza sativa)
Liliopsida Os08g0187800 35
  • 45.62 (n)
  • 36.86 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05453 35
  • 47.62 (n)
  • 34.11 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC83.11 35
  • 40.14 (n)
  • 34.37 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToMany
Species with no ortholog for SLC35E1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35E1 Gene

ENSEMBL:
Gene Tree for SLC35E1 (if available)
TreeFam:
Gene Tree for SLC35E1 (if available)

Paralogs for SLC35E1 Gene

Paralogs for SLC35E1 Gene

(1) SIMAP similar genes for SLC35E1 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC35E1 Gene

genes like me logo Genes that share paralogs with SLC35E1: view

Variants for SLC35E1 Gene

Sequence variations from dbSNP and Humsavar for SLC35E1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs8101092 -- 16,562,333(+) atgtc(A/G)ttatg intron-variant
rs12982066 -- 16,569,653(+) ccagc(C/T)tggcc intron-variant
rs8104501 -- 16,561,599(+) GCCAT(C/T)TGGCA intron-variant
rs71334625 -- 16,564,679(+) ATGCT(-/G)GGAGA intron-variant
rs71336778 -- 16,561,243(+) AAAAA(A/G)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35E1 Gene

Variant ID Type Subtype PubMed ID
nsv911167 CNV Loss 21882294
nsv510757 CNV Loss 20534489

Variation tolerance for SLC35E1 Gene

Residual Variation Intolerance Score: 25.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.68; 14.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35E1 Gene

HapMap Linkage Disequilibrium report
SLC35E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35E1 Gene

Disorders for SLC35E1 Gene

Relevant External Links for SLC35E1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35E1

No disorders were found for SLC35E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35E1 Gene

Publications for SLC35E1 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3
  4. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for SLC35E1 Gene

Sources for SLC35E1 Gene

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