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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35E1 Gene

protein-coding   GIFtS: 45
GCID: GC19M016660

Solute Carrier Family 35, Member E1

  Search for SLC35E1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member E11 2
Solute Carrier Family 35 Member E12

External Ids:    HGNC: 208031   Entrez Gene: 799392   Ensembl: ENSG000001275267   UniProtKB: Q96K373   

Export aliases for SLC35E1 gene to outside databases

Previous GC identifers: GC19M016507 GC19M016523 GC19M016522 GC19M016229


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC35E1 Gene: 
SLC35E1 (solute carrier family 35, member E1) is a protein-coding gene. An important paralog of this gene is SLC35E2.

UniProtKB/Swiss-Prot: S35E1_HUMAN, Q96K37
Function: Putative transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC35E1 gene promoter:
         AML1a   Tal-1beta   Roaz   CP2   POU2F1   Ik-2   POU2F1a   ITF-2   NF-Y   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35E1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC35E1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.11   Ensembl cytogenetic band:  19p13.11   HGNC cytogenetic band: 19p13.11

SLC35E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35E1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M016660:  view genomic region     (about GC identifiers)

Start:
16,660,642 bp from pter      End:
16,683,193 bp from pter
Size:
22,552 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: S35E1_HUMAN, Q96K37 (See protein sequence)
Recommended Name: Solute carrier family 35 member E1  
Size: 410 amino acids; 44773 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH14557.1; Type=Frameshift; Positions=372, 384; Sequence=AAH62562.1; Type=Erroneous
initiation; Sequence=BAB55306.1; Type=Erroneous initiation; Sequence=BAB55410.1; Type=Erroneous initiation;
Sequence=BAC11565.1; Type=Erroneous initiation;
Secondary accessions: Q8NBQ2 Q96JV7
Alternative splicing: 3 isoforms:  Q96K37-1   Q96K37-2   Q96K37-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35E1: NX_Q96K37

Explore proteomics data for SLC35E1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96K37

  • SLC35E1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC35E1 Protein Expression
    REFSEQ proteins: NP_079157.3  
    ENSEMBL proteins: 
     ENSP00000470652   ENSP00000387152   ENSP00000400435   ENSP00000394092   ENSP00000397670  

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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC35E1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC35E1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: SLC35E1 
    SLC35 family of nucleotide sugar transporters

    2 InterPro protein domains:
     IPR004853 DUF250
     IPR000620 DMT

    Graphical View of Domain Structure for InterPro Entry Q96K37

    ProtoNet protein and cluster: Q96K37

    UniProtKB/Swiss-Prot: S35E1_HUMAN, Q96K37
    Similarity: Belongs to the TPT transporter family. SLC35E subfamily


    SLC35E1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35E1_HUMAN, Q96K37
    Function: Putative transporter (By similarity)

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC35E1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC35E1 
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    SwitchGear 3'UTR luciferase reporter plasmidSLC35E1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35E1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/6 Interacting proteins for SLC35E1 (Q96K372, 3 ENSP000003871524) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABCF3Q9NUQ82, 3, ENSP000004114714MINT-65162 I2D: score=3 STRING: ENSP00000411471
    LAMA3Q167872, 3, ENSP000003245324MINT-64295 I2D: score=3 STRING: ENSP00000324532
    MCOLN1Q9GZU12, 3MINT-65432 I2D: score=4 
    FXYD6Q9H0Q32, 3, ENSP000002602824MINT-65444 I2D: score=4 STRING: ENSP00000260282
    CLN3Q132863I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport IEA--
    GO:0055085transmembrane transport ----

    SLC35E1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC35E1 (S35E1)

    Search CenterWatch for drugs/clinical trials and news about SLC35E1 / S35E1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC35E1 gene: 
    NM_024881.4  

    Unigene Cluster for SLC35E1:

    Solute carrier family 35, member E1
    Hs.620596  [show with all ESTs]
    Unigene Representative Sequence: NM_024881
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000593812 ENST00000595753 ENST00000409648(uc010xph.2) ENST00000596387
    ENST00000436553 ENST00000600356 ENST00000421082 ENST00000469055 ENST00000470077
    ENST00000488894(uc002nem.1) ENST00000431408
    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC35E1 (see all 40):
    hsa-miR-302d hsa-miR-520e hsa-miR-570 hsa-miR-372 hsa-miR-302b hsa-miR-4309 hsa-miR-520b hsa-miR-181b
    SwitchGear 3'UTR luciferase reporter plasmidSLC35E1 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK024313.1 AK027699.1 AK027850.1 AL080085.1 BC007731.2 BC014557.2 BC062562.1 CR457326.1 

    22 DOTS entries:

    DT.421616  DT.92011270  DT.99948759  DT.100029720  DT.95374612  DT.91753715  DT.206403  DT.100780352 
    DT.121500644  DT.121500699  DT.100740287  DT.100780351  DT.100780347  DT.121500552  DT.207958  DT.65286070 
    DT.75194342  DT.91991483  DT.95256595  DT.100750938  DT.121500700  DT.95374616 

    24/235 AceView cDNA sequences (see all 235):

    BF516582 BE269184 BQ708653 BE786116 CA944577 AI087204 BU844517 CA503264 
    BE673109 BM457652 CD365764 AA056484 BE348724 CB154403 AI687964 BG747689 
    AI951641 AA541579 AI073694 AA362575 BX105710 AW207460 BP345761 CF265149 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35E1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d
    SP1:                                      -     -     -     -                                       
    SP2:                    -                 -     -     -     -                                       
    SP3:                                            -     -     -                                       
    SP4:                                                  -     -                                       
    SP5:                                                        -                                       


    ECgene alternative splicing isoforms for SLC35E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC35E1 expression in normal human tissues (normalized intensities)      SLC35E1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC35E1 Expression
    About this image


    SLC35E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             ganglion/cranial/facial VII   
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Positive Thymocytes Thymus
             platelets   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See SLC35E1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC35E1

    SOURCE GeneReport for Unigene cluster: Hs.620596
        SABiosciences Custom PCR Arrays for SLC35E1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC35E1 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35e11 , 5 solute carrier family 35, member E11, 5 85.91(n)1
    91.4(a)1
      8 (35.08 cM)5
    2700661  NM_177766.31  NP_808434.21 
     724806415 
    chicken
    (Gallus gallus)
    Aves SLC35E11 solute carrier family 35, member E1 76.15(n)
    81.86(a)
      420143  XM_418259.3  XP_418259.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35E16
    Uncharacterized protein
    55(a)
    1 ↔ 1
    AAWZ02041672(1273-4576)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.113692 Xenopus laevis transcribed sequence with moderate similarity more 76.78(n)    BQ736214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.37622 Danio rerio mRNA similar to hypothetical protein FLJ14251 more 74.8(n)    BC046896.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146211 CG14621 56.94(n)
    50(a)
      33128  NM_134614.1  NP_608458.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SLY411 Sly41p 39.09(n)
    28.99(a)
      854484   NP_014952.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PPT21 phosphoenolpyruvate (pep)/phosphate translocator 2 41.89(n)
    32.33(a)
      821114  NM_111021.3  NP_566142.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01721001 hypothetical protein 46.64(n)
    34.32(a)
      4327644  NM_001048685.1  NP_001042150.1 


    ENSEMBL Gene Tree for SLC35E1 (if available)
    TreeFam Gene Tree for SLC35E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC35E1 gene
    SLC35E22  SLC35E2B2  
    1 SIMAP similar gene for SLC35E1 using alignment to 4 protein entries:     S35E1_HUMAN (see all proteins):
    SLC35E2B

    SLC35E1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC35E1
    PGOHUM00000248512


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/491 SNPs in SLC35E1 are shown (see all 491)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1163293151,2
    C,F--16660240(+) TCCCTT/CGAGTC 1 -- int11Minor allele frequency- C:0.09WA 118
    rs48085151,2
    C,H--16660478(+) CAAATC/TGCACG 1 -- int113Minor allele frequency- T:0.00NA WA CSA EA 376
    rs735149401,2
    C--16660576(+) ACATTC/TTGTTG 1 -- int11Minor allele frequency- T:0.50WA 2
    rs124595491,2
    C,F,H--16660757(+) TTGAAA/GAACAT 1 -- ut316Minor allele frequency- G:0.05NS EA NA 500
    rs735149421,2
    C--16661113(+) CTGATG/AGGTAA 1 -- ut314Minor allele frequency- A:0.03WA NA EA 360
    rs1148164571,2
    C,F--16661219(+) CTGTCC/TGGCTG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1867834661,2
    --16661340(+) AGTTCA/GAGACC 1 -- ut310--------
    rs1451889261,2
    C--16661499(+) GACTGC/TGCCAC 1 -- ut310--------
    rs556519391,2
    --16661552(+) GGGGGC/G/TGGGGG 2 -- ut310--------
    rs2013080431,2
    C--16661552(+) GGGGG-/CGGGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC35E1 (16660642 - 16683193 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC35E1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv911167CNV Loss21882294
    nsv510757CNV Loss20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC35E1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with SLC35E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79939 HGNC: 20803 AceView: SLC35E1 Ensembl:ENSG00000127526 euGenes: HUgn79939
    ECgene: SLC35E1 H-InvDB: SLC35E1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC35E1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC35E1 gene:
    Search GeneIP for patents involving SLC35E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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