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Aliases for SLC35D3 Gene

Aliases for SLC35D3 Gene

  • Solute Carrier Family 35 Member D3 2 3 5
  • Fringe Connection-Like Protein 1 3 4
  • FRCL1 3 4
  • Solute Carrier Family 35, Member D3 2
  • Frc, Fringe-Like 1 3

External Ids for SLC35D3 Gene

Previous HGNC Symbols for SLC35D3 Gene

  • FRCL1

Previous GeneCards Identifiers for SLC35D3 Gene

  • GC06P137178
  • GC06P137223
  • GC06P137218
  • GC06P137279
  • GC06P137287
  • GC06P137243
  • GC06P134808

Summaries for SLC35D3 Gene

GeneCards Summary for SLC35D3 Gene

SLC35D3 (Solute Carrier Family 35 Member D3) is a Protein Coding gene. An important paralog of this gene is SLC35D1.

UniProtKB/Swiss-Prot for SLC35D3 Gene

  • May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35D3 Gene

Genomics for SLC35D3 Gene

Regulatory Elements for SLC35D3 Gene

Enhancers for SLC35D3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC35D3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35D3 Gene

136,922,241 bp from pter
136,925,660 bp from pter
3,420 bases
Plus strand

Genomic View for SLC35D3 Gene

Genes around SLC35D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35D3 Gene

Proteins for SLC35D3 Gene

  • Protein details for SLC35D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member D3
    Protein Accession:
    Secondary Accessions:
    • B4DI58
    • Q5QNZ6
    • Q6NX71

    Protein attributes for SLC35D3 Gene

    416 amino acids
    Molecular mass:
    44183 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC35D3 Gene

Post-translational modifications for SLC35D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35D3 Gene

Domains & Families for SLC35D3 Gene

Gene Families for SLC35D3 Gene

Protein Domains for SLC35D3 Gene


Suggested Antigen Peptide Sequences for SLC35D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35D subfamily.
  • Belongs to the TPT transporter family. SLC35D subfamily.
genes like me logo Genes that share domains with SLC35D3: view

Function for SLC35D3 Gene

Molecular function for SLC35D3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.
genes like me logo Genes that share phenotypes with SLC35D3: view

Animal Model Products

CRISPR Products

miRNA for SLC35D3 Gene

miRTarBase miRNAs that target SLC35D3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35D3 Gene

Localization for SLC35D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC35D3 Gene COMPARTMENTS Subcellular localization image for SLC35D3 gene
Compartment Confidence
plasma membrane 3
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35D3: view

Pathways & Interactions for SLC35D3 Gene

SuperPathways for SLC35D3 Gene

No Data Available

Interacting Proteins for SLC35D3 Gene

Gene Ontology (GO) - Biological Process for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
GO:0070863 positive regulation of protein exit from endoplasmic reticulum IEA --
GO:0097009 energy homeostasis IEA --
genes like me logo Genes that share ontologies with SLC35D3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35D3 Gene

Drugs & Compounds for SLC35D3 Gene

No Compound Related Data Available

Transcripts for SLC35D3 Gene

mRNA/cDNA for SLC35D3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35D3 Gene

Solute carrier family 35, member D3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D3 Gene

No ASD Table

Relevant External Links for SLC35D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35D3 Gene

mRNA expression in normal human tissues for SLC35D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35D3 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x14.8), Brain - Nucleus accumbens (basal ganglia) (x11.0), Brain - Putamen (basal ganglia) (x10.4), and Brain - Hypothalamus (x8.1).

Protein differential expression in normal tissues from HIPED for SLC35D3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3), Testis (21.8), and Platelet (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35D3 Gene

Protein tissue co-expression partners for SLC35D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35D3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35D3 Gene:

genes like me logo Genes that share expression patterns with SLC35D3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC35D3 Gene

Orthologs for SLC35D3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC35D3 34
  • 91.11 (n)
  • 92.55 (a)
SLC35D3 35
  • 91 (a)
(Canis familiaris)
Mammalia SLC35D3 34
  • 91.11 (n)
  • 90.62 (a)
SLC35D3 35
  • 90 (a)
(Mus musculus)
Mammalia Slc35d3 34
  • 88.38 (n)
  • 91.35 (a)
Slc35d3 16
Slc35d3 35
  • 90 (a)
(Pan troglodytes)
Mammalia SLC35D3 34
  • 99.44 (n)
  • 99.52 (a)
SLC35D3 35
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc35d3 34
  • 89.58 (n)
  • 93.27 (a)
(Monodelphis domestica)
Mammalia SLC35D3 35
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 73 (a)
-- 35
  • 87 (a)
(Gallus gallus)
Aves SLC35D3 34
  • 75.28 (n)
  • 74.39 (a)
SLC35D3 35
  • 71 (a)
(Anolis carolinensis)
Reptilia SLC35D3 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35d3 34
  • 66.58 (n)
  • 71.08 (a)
(Danio rerio)
Actinopterygii LOC565603 34
  • 63.57 (n)
  • 64.3 (a)
SLC35D3 35
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta frc 35
  • 20 (a)
(Caenorhabditis elegans)
Secernentea sqv-7 35
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31600 34
  • 43.56 (n)
  • 31 (a)
(Oryza sativa)
Liliopsida Os06g0188100 34
  • 42.84 (n)
  • 30.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2519 35
  • 29 (a)
Species where no ortholog for SLC35D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35D3 Gene

Gene Tree for SLC35D3 (if available)
Gene Tree for SLC35D3 (if available)

Paralogs for SLC35D3 Gene

Paralogs for SLC35D3 Gene

genes like me logo Genes that share paralogs with SLC35D3: view

Variants for SLC35D3 Gene

Sequence variations from dbSNP and Humsavar for SLC35D3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1055268 -- 136,925,258(-) CAATA(A/G)TAGGA utr-variant-3-prime
rs1167978 -- 136,922,499(+) TGAGG(A/C/G/T)AGCCC reference, missense
rs6928760 -- 136,920,544(+) TTGAC(A/C)CCGAG upstream-variant-2KB
rs1890389 -- 136,921,635(-) CTCGG(A/C)GCCCG upstream-variant-2KB
rs7747143 -- 136,920,958(+) ACGGT(C/T)ACCTC upstream-variant-2KB

Variation tolerance for SLC35D3 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35D3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35D3 Gene

Disorders for SLC35D3 Gene

Relevant External Links for SLC35D3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35D3 Gene

Publications for SLC35D3 Gene

  1. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 65
  2. Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons. (PMID: 24550737) Zhang Z. … Li W. (PLoS Genet. 2014) 3 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 65

Products for SLC35D3 Gene

Sources for SLC35D3 Gene

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