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Aliases for SLC35D3 Gene

Aliases for SLC35D3 Gene

  • Solute Carrier Family 35, Member D3 2 3
  • Fringe Connection-Like Protein 1 3 4
  • FRCL1 3 4
  • Solute Carrier Family 35 Member D3 3
  • Frc, Fringe-Like 1 3

External Ids for SLC35D3 Gene

Previous HGNC Symbols for SLC35D3 Gene

  • FRCL1

Previous GeneCards Identifiers for SLC35D3 Gene

  • GC06P137178
  • GC06P137223
  • GC06P137218
  • GC06P137279
  • GC06P137287
  • GC06P137243
  • GC06P134808

Summaries for SLC35D3 Gene

GeneCards Summary for SLC35D3 Gene

SLC35D3 (Solute Carrier Family 35, Member D3) is a Protein Coding gene. Diseases associated with SLC35D3 include chediak-higashi syndrome and hermansky-pudlak syndrome. An important paralog of this gene is SLC35D2.

UniProtKB/Swiss-Prot for SLC35D3 Gene

  • May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35D3 Gene

Genomics for SLC35D3 Gene

Regulatory Elements for SLC35D3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC35D3 Gene

136,922,264 bp from pter
136,925,639 bp from pter
3,376 bases
Plus strand

Genomic View for SLC35D3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35D3 Gene

Proteins for SLC35D3 Gene

  • Protein details for SLC35D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member D3
    Protein Accession:
    Secondary Accessions:
    • B4DI58
    • Q5QNZ6
    • Q6NX71

    Protein attributes for SLC35D3 Gene

    416 amino acids
    Molecular mass:
    44183 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC35D3 Gene

Proteomics data for SLC35D3 Gene at MOPED

Post-translational modifications for SLC35D3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35D3 Gene

Domains for SLC35D3 Gene

Gene Families for SLC35D3 Gene

  • SLC :Solute carriers

Protein Domains for SLC35D3 Gene


Suggested Antigen Peptide Sequences for SLC35D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q5M8T2
  • Belongs to the TPT transporter family. SLC35D subfamily.
genes like me logo Genes that share domains with SLC35D3: view

Function for SLC35D3 Gene

Molecular function for SLC35D3 Gene

UniProtKB/Swiss-Prot Function: May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.

Phenotypes for SLC35D3 Gene

genes like me logo Genes that share phenotypes with SLC35D3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC35D3 Gene

Localization for SLC35D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC35D3 Gene COMPARTMENTS Subcellular localization image for SLC35D3 gene
Compartment Confidence
plasma membrane 3
lysosome 2
cytoskeleton 1
cytosol 1
endosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35D3: view

Pathways for SLC35D3 Gene

SuperPathways for SLC35D3 Gene

No Data Available

Interacting Proteins for SLC35D3 Gene

Gene Ontology (GO) - Biological Process for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008643 carbohydrate transport IEA --
genes like me logo Genes that share ontologies with SLC35D3: view

No data available for Pathways by source for SLC35D3 Gene

Transcripts for SLC35D3 Gene

mRNA/cDNA for SLC35D3 Gene

(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35D3 Gene

Solute carrier family 35, member D3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35D3

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SLC35D3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D3 Gene

No ASD Table

Relevant External Links for SLC35D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35D3 Gene

mRNA expression in normal human tissues for SLC35D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35D3 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (14.8), Brain - Nucleus accumbens (basal ganglia) (11.0), Brain - Putamen (basal ganglia) (10.4), and Brain - Hypothalamus (8.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC35D3 Gene

SOURCE GeneReport for Unigene cluster for SLC35D3 Gene Hs.369703

genes like me logo Genes that share expressions with SLC35D3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC35D3 Gene

Orthologs for SLC35D3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35D3 35
  • 99.44 (n)
  • 99.52 (a)
SLC35D3 36
  • 100 (a)
(Bos Taurus)
Mammalia SLC35D3 35
  • 91.11 (n)
  • 92.55 (a)
SLC35D3 36
  • 91 (a)
(Canis familiaris)
Mammalia SLC35D3 35
  • 91.11 (n)
  • 90.62 (a)
SLC35D3 36
  • 90 (a)
(Mus musculus)
Mammalia Slc35d3 35
  • 88.38 (n)
  • 91.35 (a)
Slc35d3 16
Slc35d3 36
  • 90 (a)
(Monodelphis domestica)
Mammalia SLC35D3 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Slc35d3 35
  • 89.58 (n)
  • 93.27 (a)
(Gallus gallus)
Aves SLC35D3 35
  • 75.28 (n)
  • 74.39 (a)
SLC35D3 36
  • 71 (a)
(Anolis carolinensis)
Reptilia SLC35D3 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35d3 35
  • 66.58 (n)
  • 71.08 (a)
(Danio rerio)
Actinopterygii LOC565603 35
  • 63.57 (n)
  • 64.3 (a)
SLC35D3 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta frc 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea sqv-7 36
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31600 35
  • 43.56 (n)
  • 31 (a)
(Oryza sativa)
Liliopsida Os06g0188100 35
  • 42.84 (n)
  • 30.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2519 36
  • 29 (a)
Species with no ortholog for SLC35D3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35D3 Gene

Gene Tree for SLC35D3 (if available)
Gene Tree for SLC35D3 (if available)

Paralogs for SLC35D3 Gene

Paralogs for SLC35D3 Gene

genes like me logo Genes that share paralogs with SLC35D3: view

Variants for SLC35D3 Gene

Sequence variations from dbSNP and Humsavar for SLC35D3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1167978 -- 136,922,499(-) TGAGG(A/G)AGCCC reference, missense
rs1890389 -- 136,921,635(-) CTCGG(A/C)GCCCG upstream-variant-2KB
rs6928760 -- 136,920,544(+) TTGAC(A/C)CCGAG upstream-variant-2KB
rs7747143 -- 136,920,958(+) ACGGT(C/T)ACCTC upstream-variant-2KB
rs7763578 -- 136,926,104(+) cagag(C/T)gagac downstream-variant-500B

Relevant External Links for SLC35D3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35D3 Gene

Disorders for SLC35D3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for SLC35D3 Gene including...

Search for SLC35D3 Gene in MalaCards »

(2) University of Copenhagen DISEASES for SLC35D3 Gene

genes like me logo Genes that share disorders with SLC35D3: view

No data available for UniProtKB/Swiss-Prot for SLC35D3 Gene

Publications for SLC35D3 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons. (PMID: 24550737) Zhang Z. … Li W. (PLoS Genet. 2014) 3
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for SLC35D3 Gene

Sources for SLC35D3 Gene

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