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Aliases for SLC35D3 Gene

Aliases for SLC35D3 Gene

  • Solute Carrier Family 35 Member D3 2 3 5
  • Fringe Connection-Like Protein 1 3 4
  • FRCL1 3 4
  • Solute Carrier Family 35, Member D3 2
  • Frc, Fringe-Like 1 3

External Ids for SLC35D3 Gene

Previous HGNC Symbols for SLC35D3 Gene

  • FRCL1

Previous GeneCards Identifiers for SLC35D3 Gene

  • GC06P137178
  • GC06P137223
  • GC06P137218
  • GC06P137279
  • GC06P137287
  • GC06P137243
  • GC06P134808

Summaries for SLC35D3 Gene

GeneCards Summary for SLC35D3 Gene

SLC35D3 (Solute Carrier Family 35 Member D3) is a Protein Coding gene. An important paralog of this gene is SLC35D1.

UniProtKB/Swiss-Prot for SLC35D3 Gene

  • May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.

Additional gene information for SLC35D3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35D3 Gene

Genomics for SLC35D3 Gene

GeneHancer (GH) Regulatory Elements for SLC35D3 Gene

Promoters and enhancers for SLC35D3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I136920 Promoter/Enhancer 1.8 EPDnew FANTOM5 Ensembl ENCODE 570 +0.2 207 3.4 ZNF76 ZNF2 RFX5 ZNF335 GLIS2 SCRT2 IKZF2 EGR2 ZNF202 ZBTB11 SLC35D3 GC06M136918 BCLAF1 PEX7 IL20RA ENSG00000207247
GH06I136989 Enhancer 1.2 FANTOM5 Ensembl ENCODE 1.4 +67.6 67578 1.5 KLF17 BACH1 ZIC2 ZNF2 ZNF335 ZFHX2 GLIS2 POLR2A ZBTB48 PATZ1 IL20RA SLC35D3 NHEG1 RPL35AP3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35D3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35D3 gene promoter:

Genomic Locations for SLC35D3 Gene

Genomic Locations for SLC35D3 Gene
3,420 bases
Plus strand

Genomic View for SLC35D3 Gene

Genes around SLC35D3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35D3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35D3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35D3 Gene

Proteins for SLC35D3 Gene

  • Protein details for SLC35D3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member D3
    Protein Accession:
    Secondary Accessions:
    • B4DI58
    • Q5QNZ6
    • Q6NX71

    Protein attributes for SLC35D3 Gene

    416 amino acids
    Molecular mass:
    44183 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC35D3 Gene

Post-translational modifications for SLC35D3 Gene

No Post-translational modifications

Other Protein References for SLC35D3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35D3 Gene

Domains & Families for SLC35D3 Gene

Gene Families for SLC35D3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35D3 Gene


Suggested Antigen Peptide Sequences for SLC35D3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPT transporter family. SLC35D subfamily.
  • Belongs to the TPT transporter family. SLC35D subfamily.
genes like me logo Genes that share domains with SLC35D3: view

Function for SLC35D3 Gene

Molecular function for SLC35D3 Gene

UniProtKB/Swiss-Prot Function:
May play a role in hemostasis as a regulator of the biosynthesis of platelet-dense granules.

Phenotypes From GWAS Catalog for SLC35D3 Gene

Gene Ontology (GO) - Molecular Function for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC35D3: view
genes like me logo Genes that share phenotypes with SLC35D3: view

Animal Model Products

miRNA for SLC35D3 Gene

miRTarBase miRNAs that target SLC35D3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35D3 Gene

Localization for SLC35D3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35D3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35D3 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
endosome 3
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubule organizing center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35D3: view

Pathways & Interactions for SLC35D3 Gene

SuperPathways for SLC35D3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35D3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0034219 carbohydrate transmembrane transport IBA --
GO:0070863 positive regulation of protein exit from endoplasmic reticulum IEA --
GO:0090481 pyrimidine nucleotide-sugar transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC35D3: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35D3 Gene

Drugs & Compounds for SLC35D3 Gene

No Compound Related Data Available

Transcripts for SLC35D3 Gene

mRNA/cDNA for SLC35D3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC35D3 Gene

Solute carrier family 35, member D3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D3 Gene

No ASD Table

Relevant External Links for SLC35D3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35D3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35D3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC35D3 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (x14.8), Brain - Nucleus accumbens (basal ganglia) (x11.0), Brain - Putamen (basal ganglia) (x10.4), and Brain - Hypothalamus (x8.1).

Protein differential expression in normal tissues from HIPED for SLC35D3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.3), Testis (21.8), and Platelet (18.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35D3 Gene

Protein tissue co-expression partners for SLC35D3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35D3 Gene:


SOURCE GeneReport for Unigene cluster for SLC35D3 Gene:


Evidence on tissue expression from TISSUES for SLC35D3 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC35D3: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35D3 Gene

Orthologs for SLC35D3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35D3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35D3 33 34
  • 99.44 (n)
(Bos Taurus)
Mammalia SLC35D3 33 34
  • 91.11 (n)
(Canis familiaris)
Mammalia SLC35D3 33 34
  • 91.11 (n)
(Rattus norvegicus)
Mammalia Slc35d3 33
  • 89.58 (n)
(Mus musculus)
Mammalia Slc35d3 33 16 34
  • 88.38 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 87 (a)
-- 34
  • 73 (a)
(Monodelphis domestica)
Mammalia SLC35D3 34
  • 81 (a)
(Gallus gallus)
Aves SLC35D3 33 34
  • 75.28 (n)
(Anolis carolinensis)
Reptilia SLC35D3 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35d3 33
  • 66.58 (n)
(Danio rerio)
Actinopterygii LOC565603 33
  • 63.57 (n)
SLC35D3 34
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta frc 34
  • 20 (a)
(Caenorhabditis elegans)
Secernentea sqv-7 34
  • 22 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31600 33
  • 43.56 (n)
(Oryza sativa)
Liliopsida Os06g0188100 33
  • 42.84 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2519 34
  • 29 (a)
Species where no ortholog for SLC35D3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35D3 Gene

Gene Tree for SLC35D3 (if available)
Gene Tree for SLC35D3 (if available)

Paralogs for SLC35D3 Gene

Paralogs for SLC35D3 Gene

genes like me logo Genes that share paralogs with SLC35D3: view

Variants for SLC35D3 Gene

Sequence variations from dbSNP and Humsavar for SLC35D3 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1001131398 -- 136,923,669(+) C/T intron_variant
rs1001477900 -- 136,923,532(+) C/T intron_variant
rs1001872023 -- 136,925,001(+) C/A 3_prime_UTR_variant
rs1002860624 -- 136,925,080(+) G/C 3_prime_UTR_variant
rs1003134619 -- 136,920,567(+) A/G upstream_transcript_variant

Variation tolerance for SLC35D3 Gene

Residual Variation Intolerance Score: 44.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35D3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC35D3 Gene

Disorders for SLC35D3 Gene

Additional Disease Information for SLC35D3

No disorders were found for SLC35D3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35D3 Gene

Publications for SLC35D3 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp JJ … Guthrie C (Nature structural & molecular biology 2015) 3 58
  3. Mutation of SLC35D3 causes metabolic syndrome by impairing dopamine signaling in striatal D1 neurons. (PMID: 24550737) Zhang Z … Li W (PLoS genetics 2014) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58

Products for SLC35D3 Gene

Sources for SLC35D3 Gene

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