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Aliases for SLC35D2 Gene

Aliases for SLC35D2 Gene

  • Solute Carrier Family 35 Member D2 2 3 4
  • Solute Carrier Family 35 (UDP-GlcNAc/UDP-Glucose Transporter), Member D2 2 3 5
  • UDP-Galactose Transporter-Related Protein 8 3 4
  • Homolog Of Fringe Connection Protein 1 3 4
  • Solute Carrier Family 35, Member D2 2 3
  • SQV7-Like Protein 3 4
  • UGTrel8 3 4
  • HFRC1 3 4
  • SQV7L 3 4
  • Hfrc 3 4
  • UDP-N-Acetylglucosamine Transporter 3
  • Fringe Connection 3

External Ids for SLC35D2 Gene

Previous GeneCards Identifiers for SLC35D2 Gene

  • GC09M092533
  • GC09M094462
  • GC09M096162
  • GC09M098122
  • GC09M099082
  • GC09M068694

Summaries for SLC35D2 Gene

Entrez Gene Summary for SLC35D2 Gene

  • Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35D2 Gene

SLC35D2 (Solute Carrier Family 35 Member D2) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35D3.

UniProtKB/Swiss-Prot for SLC35D2 Gene

  • Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35D2 Gene

Genomics for SLC35D2 Gene

Regulatory Elements for SLC35D2 Gene

Promoters for SLC35D2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35D2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35D2 Gene

Chromosome:
9
Start:
96,313,437 bp from pter
End:
96,383,710 bp from pter
Size:
70,274 bases
Orientation:
Minus strand

Genomic View for SLC35D2 Gene

Genes around SLC35D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35D2 Gene

Proteins for SLC35D2 Gene

  • Protein details for SLC35D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76EJ3-S35D2_HUMAN
    Recommended name:
    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
    Protein Accession:
    Q76EJ3
    Secondary Accessions:
    • O95454
    • Q498C1
    • Q75W21
    • Q7Z5X5

    Protein attributes for SLC35D2 Gene

    Size:
    337 amino acids
    Molecular mass:
    36673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35D2 Gene

Proteomics data for SLC35D2 Gene at MOPED

Post-translational modifications for SLC35D2 Gene

No Post-translational modifications

Other Protein References for SLC35D2 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC35D2

No data available for DME Specific Peptides for SLC35D2 Gene

Domains & Families for SLC35D2 Gene

Gene Families for SLC35D2 Gene

Protein Domains for SLC35D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q76EJ3

UniProtKB/Swiss-Prot:

S35D2_HUMAN :
  • Belongs to the TPT transporter family. SLC35D subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35D subfamily.
genes like me logo Genes that share domains with SLC35D2: view

Function for SLC35D2 Gene

Molecular function for SLC35D2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for UDP-N-acetylglucosamine {ECO:0000269 PubMed:15082721}; KM=2.1 uM for UDP-glucose {ECO:0000269 PubMed:15082721}; KM=0.14 uM for GDP-mannose {ECO:0000269 PubMed:15082721};
UniProtKB/Swiss-Prot Function:
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.
genes like me logo Genes that share phenotypes with SLC35D2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35D2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35D2 Gene

Localization for SLC35D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35D2 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35D2 Gene COMPARTMENTS Subcellular localization image for SLC35D2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for SLC35D2 Gene

Pathways & Interactions for SLC35D2 Gene

genes like me logo Genes that share pathways with SLC35D2: view

Interacting Proteins for SLC35D2 Gene

Gene Ontology (GO) - Biological Process for SLC35D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0018146 keratan sulfate biosynthetic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SLC35D2: view

No data available for SIGNOR curated interactions for SLC35D2 Gene

Drugs & Compounds for SLC35D2 Gene

No Compound Related Data Available

Transcripts for SLC35D2 Gene

Unigene Clusters for SLC35D2 Gene

Solute carrier family 35, member D2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5:

Relevant External Links for SLC35D2 Gene

GeneLoc Exon Structure for
SLC35D2
ECgene alternative splicing isoforms for
SLC35D2

Expression for SLC35D2 Gene

mRNA expression in normal human tissues for SLC35D2 Gene

Protein differential expression in normal tissues from HIPED for SLC35D2 Gene

This gene is overexpressed in Adipocyte (62.1) and Fetal Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC35D2 Gene



SOURCE GeneReport for Unigene cluster for SLC35D2 Gene Hs.494556

mRNA Expression by UniProt/SwissProt for SLC35D2 Gene

Q76EJ3-S35D2_HUMAN
Tissue specificity: Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.
genes like me logo Genes that share expression patterns with SLC35D2: view

Protein tissue co-expression partners for SLC35D2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC35D2 Gene

Orthologs for SLC35D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35D2 35
  • 99.8 (n)
  • 99.7 (a)
SLC35D2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35D2 36
  • 91 (a)
OneToOne
SLC35D2 35
  • 91.48 (n)
  • 93.38 (a)
dog
(Canis familiaris)
Mammalia SLC35D2 35
  • 91.48 (n)
  • 93.15 (a)
SLC35D2 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35d2 16
Slc35d2 35
  • 87.72 (n)
  • 91.33 (a)
Slc35d2 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35D2 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35d2 35
  • 88.03 (n)
  • 90.71 (a)
chicken
(Gallus gallus)
Aves SLC35D2 35
  • 72.63 (n)
  • 72.14 (a)
lizard
(Anolis carolinensis)
Reptilia SLC35D2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35d2 35
  • 66.34 (n)
  • 64.47 (a)
Str.16667 35
zebrafish
(Danio rerio)
Actinopterygii slc35d2 36
  • 64 (a)
OneToOne
LOC100534928 35
  • 63.14 (n)
  • 62.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta frc 36
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sqv-7 36
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for SLC35D2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35D2 Gene

ENSEMBL:
Gene Tree for SLC35D2 (if available)
TreeFam:
Gene Tree for SLC35D2 (if available)

Paralogs for SLC35D2 Gene

Paralogs for SLC35D2 Gene

(1) SIMAP similar genes for SLC35D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC35D2: view

Variants for SLC35D2 Gene

Sequence variations from dbSNP and Humsavar for SLC35D2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1051763 - 96,345,340(-) TCACA(G/T)CAGCA intron-variant, nc-transcript-variant, reference, missense
rs1133951 -- 96,350,390(-) attgt(G/T)agaac intron-variant
rs1225273 -- 96,322,815(+) ccagg(G/T)tcaag intron-variant
rs2026002 -- 96,321,899(-) TTTCA(C/T)GTTAA intron-variant
rs4543665 -- 96,322,565(+) AATAA(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35D2 Gene

Variant ID Type Subtype PubMed ID
nsv893602 CNV Gain 21882294
nsv893603 CNV Gain 21882294

Variation tolerance for SLC35D2 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35D2 Gene

HapMap Linkage Disequilibrium report
SLC35D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35D2 Gene

Disorders for SLC35D2 Gene

Relevant External Links for SLC35D2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35D2

No disorders were found for SLC35D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35D2 Gene

Publications for SLC35D2 Gene

  1. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. (PMID: 15607426) Ishida N. … Sanai Y. (Genomics 2005) 2 3 4 23 67
  2. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. (PMID: 15082721) Suda T. … Nishihara S. (J. Biol. Chem. 2004) 3 23
  3. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V. … . (Nat. Genet. 2013) 3
  4. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (PMID: 23144319) Lee Y. … Lee J.S. (Carcinogenesis 2013) 3
  5. Endoplasmic reticulum/golgi nucleotide sugar transporters contribute to the cellular release of UDP-sugar signaling molecules. (PMID: 19276090) Sesma J.I. … Lazarowski E.R. (J. Biol. Chem. 2009) 3

Products for SLC35D2 Gene

Sources for SLC35D2 Gene

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