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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC35D2 Gene

protein-coding   GIFtS: 47
GCID: GC09M099082

solute carrier family 35, member D2

 Explore 1 disease affiliated with
SLC35D2 via our new
 Human Malady Compendium 
Biological research products
for SLC35D2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 35, Member D21 2     Fringe Connection2
SQV7L1 2 3 5     Hfrc1
UGTrel81 2 3     UDP-N-Acetylglucosamine Transporter2
HFRC12 3 5     UDP-N-Acetylglucosamine/UDP-Glucose/GDP-Mannose Transporter2
Homolog Of Fringe Connection Protein 12 3     HFRC3
SQV7-Like Protein2 3     UGTREL83
UDP-Galactose Transporter-Related Protein 82 3     Solute Carrier Family 35 Member D23

External Ids:    HGNC: 207991   Entrez Gene: 110462   Ensembl: ENSG000001309587   OMIM: 6091825   UniProtKB: Q76EJ33   

Export aliases for SLC35D2 gene to outside databases

Previous GC identifers: GC09M092533 GC09M094462 GC09M096162 GC09M098122 GC09M068694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC35D2:
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for
glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of
nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters,
such as SLC35D2 (Suda et al., 2004 (PubMed 15082721)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: S35D2_HUMAN, Q76EJ3
Function: Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc)
and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding
nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by
supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC35D2 gene promoter:
         TBP   FOXO3   FOXO3b   C/EBPalpha   PPAR-gamma1   Nkx6-1   TFIID   FOXO3a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35D2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC35D2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q22.32   Ensembl cytogenetic band:  9q22.32   HGNC cytogenetic band: 9q22.33

SLC35D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35D2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M099082:  view genomic region     (about GC identifiers)

Start:
99,082,988 bp from pter      End:
99,145,992 bp from pter
Size:
63,005 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: S35D2_HUMAN, Q76EJ3 (See protein sequence)
Recommended Name: UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter  
Size: 337 amino acids; 36673 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Secondary accessions: O95454 Q498C1 Q75W21 Q7Z5X5
Alternative splicing: 2 isoforms:  Q76EJ3-1   Q76EJ3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35D2: NX_Q76EJ3

SLC35D2 Protein expression data from MOPED and PaxDb:    About this image 
SLC35D2 Protein Expression

REFSEQ proteins: NP_008932.2  
ENSEMBL proteins: 
 ENSP00000253270   ENSP00000364406   ENSP00000364408  
Reactome Protein details: Q76EJ3
Human Recombinant Protein Products for SLC35D2: 
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Uscn Proteins for SLC35D2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000139Golgi membrane TAS--
GO:0005575cellular_component ND--
GO:0016021integral to membrane IEA--

SLC35D2 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC35D2 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR004853 DUF250

Graphical View of Domain Structure for InterPro Entry Q76EJ3

ProtoNet protein and cluster: Q76EJ3

UniProtKB/Swiss-Prot: S35D2_HUMAN, Q76EJ3
Similarity: Belongs to the TPT transporter family. SLC35D subfamily


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: S35D2_HUMAN, Q76EJ3
Function: Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc)
and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding
nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by
supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling
Biophysicochemical properties: Kinetic parameters: KM=8 uM for UDP-N-acetylglucosamine; KM=2.1 uM for UDP-glucose;
KM=0.14 uM for GDP-mannose;

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005338nucleotide-sugar transmembrane transporter activity NAS9927678
     
SLC35D2 for ontologies           About GeneDecksing


Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC35D2 

miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1SLC-mediated transmembrane transport
SLC-mediated transmembrane transport1.00
Transmembrane transport of small molecules0.50
2Transport of nucleotide sugars
Transport of nucleotide sugars1.00
3Transport of organic anions
Transport of vitamins, nucleosides, and related molecules0.35

Pathway sources
See GeneCards unified pathways
Show all pathways


4        Reactome Pathways for SLC35D2
    SLC-mediated transmembrane transport
Transmembrane transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Transport of nucleotide sugars



SLC35D2 for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35D2

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008150biological_process ND--
GO:0008643carbohydrate transport IEA--
GO:0015780nucleotide-sugar transport ----
GO:0055085transmembrane transport TAS--

SLC35D2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC35D2
Search CenterWatch for drugs/clinical trials and news about SLC35D2 / S35D2 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC35D2 gene: 
NM_007001.2  

Unigene Clusters for SLC35D2:

Solute carrier family 35, member D2
Hs.494556  [show with all ESTs], Hs.731624  [show with all ESTs]
Unigene Representative Sequences: AK307890, AK024841
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000253270(uc010msd.3 uc004awc.3) ENST00000490599 ENST00000375257
ENST00000482643 ENST00000375259(uc010msf.3)

miRNA
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hsa-miR-98 hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7i hsa-miR-196a hsa-let-7e hsa-let-7g
SwitchGear 3'UTR luciferase reporter plasmidSLC35D2 3' UTR sequence
Inhib. RNA
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Additional cDNA sequence: AK024841.1 

9 DOTS entries:

DT.100750159  DT.92423751  DT.95344110  DT.100019040  DT.121183296  DT.121618641  DT.315026  DT.95291721 
DT.97771598 

24/140 AceView cDNA sequences (see all 140):

BE504600 CA394282 BU623156 AA586604 CR595736 AA937708 BE049423 BC009413 
AB106537 BM841864 CR605179 BM924430 BM761207 BM760804 AA480267 AI084676 
BM675407 BM761346 AI341877 AI475475 CR615006 CR596006 CR596054 BE349543 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:                          -           -                                             
SP2:                          -           -     -     -     -                           
SP3:                          -                                                         
SP4:              -     -     -     -     -     -     -     -                           
SP5:                                                                                    


ECgene alternative splicing isoforms for SLC35D2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC35D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTTAGTCT
SLC35D2 Expression
About this image
See SLC35D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35D2

SOURCE GeneReport for Unigene clusters: Hs.494556 Hs.731624

UniProtKB/Swiss-Prot: S35D2_HUMAN, Q76EJ3
Tissue specificity: Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte.
Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35D2 gene from 9/25 species (see all 25)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc35d21 , 5 solute carrier family 35, member D21, 5 87.72(n)1
91.33(a)1
  13 (33.26 cM)5
704841  NM_001001321.31  NP_001001321.21 
 640963105 
chicken
(Gallus gallus)
Aves SLC35D26
Uncharacterized protein
71(a)
1 ↔ 1
Z(41646644-41664922)
lizard
(Anolis carolinensis)
Reptilia SLC35D26
--
73(a)
1 ↔ 1
2(39991421-40014431)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.166672 Transcribed sequence with weak similarity to protein more 73.68(n)    BX716400.1 
zebrafish
(Danio rerio)
Actinopterygii slc35d26
solute carrier family 35, member D2
64(a)
1 ↔ 1
8(1256597-1275629)
fruit fly
(Drosophila melanogaster)
Insecta frc6
fringe connection
40(a)
1 → many
3L(17422036-17426290)
worm
(Caenorhabditis elegans)
Secernentea sqv-76
UDP-sugar transporter sqv-7
47(a)
1 → many
II(7010756-7012650)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G322726
GONST16
(see all 5)
GDP-mannose transporter
(see all 5)
25(a)
21(a)
(see all 5)
many → 1
possible ortholog
(see all 5)
4(15576847-15579880)
2(5687378-5690795)
rice
(Oryza sativa)
Liliopsida --
--
(see all 7)
integral membrane protein, putative, expressed
(see all 7)
27(a)
18(a)
(see all 7)
many → 1
possible ortholog
(see all 7)
2(24229799-24233912)
2(2995483-2999836)


ENSEMBL Gene Tree for SLC35D2 (if available)
TreeFam Gene Tree for SLC35D2 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for SLC35D2 gene
SLC35D32  SLC35D12  
1 SIMAP similar gene for SLC35D2 using alignment to 2 protein entries:     S35D2_HUMAN (see all proteins):
SLC35D1

SLC35D2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1193 NCBI SNPs in SLC35D2 are shown (see all 1193    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs78543771,2
C,F,A--99082626(+) AACCTT/CGTCTC 1 -- int17Minor allele frequency- C:0.17WA NA CSA EA 365
rs1472434201,2
--99082690(+) CTACTC/TGGGAG 1 -- int10--------
rs1851594651,2
--99082747(+) GAGCCA/GAGATT 1 -- int10--------
rs113328111,2
C--99082798(+) GTCTC-/AAAAAA 1 -- int11Minor allele frequency- A:0.00CSA 2
rs348708061,2
C--99082798(+) GTCTC-/AAAAAAA 1 -- int10--------
rs1390493521,2
--99082922(+) GTGACA/GCATTC 1 -- int10--------
rs759749561,2
F--99082929(+) ATTCTG/ATTACA 1 -- int11Minor allele frequency- A:0.02WA 118
rs1898204171,2
--99082939(+) ATTGTC/GAATGA 1 -- int10--------
rs1436861971,2
--99083332(+) GTGTCA/GCCCGA 1 -- ut310--------
rs1830527131,2
--99083336(+) CGCCCA/GAGTAC 1 -- ut310--------

HapMap Linkage Disequilibrium report for SLC35D2 (99082988 - 99145992 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLC35D2: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35D2
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC35D2 for disorders           About GeneDecksing

OMIM gene information: 609182    OMIM disorders: --

1 disease for SLC35D2:    About MalaCards
shigellosis


Export disorders for SLC35D2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC35D2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35D2)
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  1. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. (PubMed id 15607426)1, 2, 3, 9 Ishida N.... Sanai Y. (2005)
  2. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. (PubMed id 15082721)1, 2, 9 Suda T.... Nishihara S. (2004)
  3. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. (PubMed id 9927678)1, 2 Herman T. and Horvitz H.R. (1999)
  4. Endoplasmic reticulum/golgi nucleotide sugar transpor ters contribute to the cellular release of UDP-sugar signaling molecules. (PubMed id 19276090)1 Sesma J.I....Lazarowski E.R. (2009)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
  7. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). (PubMed id 12759756)1 Ishida N. and Kawakita M. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 11046 HGNC: 20799 AceView: SLC35D2 Ensembl:ENSG00000130958 euGenes: HUgn11046
ECgene: SLC35D2 H-InvDB: SLC35D2

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC35D2 Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for SLC35D2 Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC35D2 gene:
Search GeneIP for patents involving SLC35D2

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