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Aliases for SLC35D2 Gene

Aliases for SLC35D2 Gene

  • Solute Carrier Family 35 Member D2 2 3 4 5
  • Solute Carrier Family 35 (UDP-GlcNAc/UDP-Glucose Transporter), Member D2 2 3
  • UDP-Galactose Transporter-Related Protein 8 3 4
  • Homolog Of Fringe Connection Protein 1 3 4
  • SQV7-Like Protein 3 4
  • UGTrel8 3 4
  • HFRC1 3 4
  • SQV7L 3 4
  • Hfrc 3 4
  • UDP-N-Acetylglucosamine/UDP-Glucose/GDP-Mannose Transporter 3
  • UDP-N-Acetylglucosamine Transporter 3
  • Solute Carrier Family 35, Member D2 2
  • Fringe Connection 3

External Ids for SLC35D2 Gene

Previous GeneCards Identifiers for SLC35D2 Gene

  • GC09M092533
  • GC09M094462
  • GC09M096162
  • GC09M098122
  • GC09M099082
  • GC09M068694

Summaries for SLC35D2 Gene

Entrez Gene Summary for SLC35D2 Gene

  • Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC35D2 Gene

SLC35D2 (Solute Carrier Family 35 Member D2) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and Glycosaminoglycan metabolism. Gene Ontology (GO) annotations related to this gene include nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35D1.

UniProtKB/Swiss-Prot for SLC35D2 Gene

  • Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.

Additional gene information for SLC35D2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35D2 Gene

Genomics for SLC35D2 Gene

GeneHancer (GH) Regulatory Elements for SLC35D2 Gene

Promoters and enhancers for SLC35D2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I096381 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.4 -433 4.8 FOXA2 ARID4B SIN3A DMAP1 ZNF48 ETS1 FOS RXRA SP5 REST SLC35D2 HABP4 LOC441455 CDC14B LOC100421693 ZNF367
GH09I096389 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -7.7 -7683 2.8 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 RXRA SP5 ZNF367 HABP4 SLC35D2 LOC100421693
GH09I096376 Enhancer 1 Ensembl ENCODE 0.4 +6.1 6070 1.6 ZNF449 JUN CEBPG ZNF2 CTBP1 GATA3 ZNF366 PRDM10 FOSL2 FOS SLC35D2 HSD17B3
GH09I096342 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.3 +39.6 39568 3.6 MEIS2 SOX13 TFAP4 PKNOX1 USF1 SAP130 MAX ZNF384 FOSL1 POLR2A HABP4 CDC14B HSD17B3 SLC35D2
GH09I096338 Enhancer 1.2 Ensembl ENCODE 0.3 +43.5 43536 3.4 ATF1 FOXA2 BRCA1 ETS1 YY1 SLC30A9 ATF7 FOS RXRA MXD4 HABP4 HSD17B3 SLC35D2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC35D2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC35D2 gene promoter:

Genomic Locations for SLC35D2 Gene

Genomic Locations for SLC35D2 Gene
chr9:96,313,437-96,383,710
(GRCh38/hg38)
Size:
70,274 bases
Orientation:
Minus strand
chr9:99,082,988-99,145,992
(GRCh37/hg19)

Genomic View for SLC35D2 Gene

Genes around SLC35D2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35D2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35D2 Gene

Proteins for SLC35D2 Gene

  • Protein details for SLC35D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q76EJ3-S35D2_HUMAN
    Recommended name:
    UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter
    Protein Accession:
    Q76EJ3
    Secondary Accessions:
    • O95454
    • Q498C1
    • Q75W21
    • Q7Z5X5

    Protein attributes for SLC35D2 Gene

    Size:
    337 amino acids
    Molecular mass:
    36673 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35D2 Gene

Post-translational modifications for SLC35D2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for SLC35D2 Gene

Domains & Families for SLC35D2 Gene

Gene Families for SLC35D2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35D2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q76EJ3

UniProtKB/Swiss-Prot:

S35D2_HUMAN :
  • Belongs to the TPT transporter family. SLC35D subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35D subfamily.
genes like me logo Genes that share domains with SLC35D2: view

Function for SLC35D2 Gene

Molecular function for SLC35D2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=8 uM for UDP-N-acetylglucosamine {ECO:0000269 PubMed:15082721}; KM=2.1 uM for UDP-glucose {ECO:0000269 PubMed:15082721}; KM=0.14 uM for GDP-mannose {ECO:0000269 PubMed:15082721};
UniProtKB/Swiss-Prot Function:
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.

Phenotypes From GWAS Catalog for SLC35D2 Gene

Gene Ontology (GO) - Molecular Function for SLC35D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005338 nucleotide-sugar transmembrane transporter activity TAS --
GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC35D2: view
genes like me logo Genes that share phenotypes with SLC35D2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35D2 Gene

Localization for SLC35D2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35D2 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35D2 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005575 cellular_component ND --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35D2: view

Pathways & Interactions for SLC35D2 Gene

genes like me logo Genes that share pathways with SLC35D2: view

Interacting Proteins for SLC35D2 Gene

Gene Ontology (GO) - Biological Process for SLC35D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006024 glycosaminoglycan biosynthetic process TAS --
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0008643 carbohydrate transport IEA --
GO:0015931 nucleobase-containing compound transport IEA --
genes like me logo Genes that share ontologies with SLC35D2: view

No data available for SIGNOR curated interactions for SLC35D2 Gene

Drugs & Compounds for SLC35D2 Gene

No Compound Related Data Available

Transcripts for SLC35D2 Gene

Unigene Clusters for SLC35D2 Gene

Solute carrier family 35, member D2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35D2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - -
SP2: - - - - -
SP3: -
SP4: - - - - - - - -
SP5:

Relevant External Links for SLC35D2 Gene

GeneLoc Exon Structure for
SLC35D2
ECgene alternative splicing isoforms for
SLC35D2

Expression for SLC35D2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35D2 Gene

Protein differential expression in normal tissues from HIPED for SLC35D2 Gene

This gene is overexpressed in Adipocyte (62.1) and Fetal Liver (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35D2 Gene



Protein tissue co-expression partners for SLC35D2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35D2 Gene:

SLC35D2

SOURCE GeneReport for Unigene cluster for SLC35D2 Gene:

Hs.494556

mRNA Expression by UniProt/SwissProt for SLC35D2 Gene:

Q76EJ3-S35D2_HUMAN
Tissue specificity: Highly expressed in heart, kidney, small intestine, placenta, lung and peripheral blood leukocyte. Weakly expressed in skeletal muscle and spleen. Not expressed in brain, colon and thymus.

Evidence on tissue expression from TISSUES for SLC35D2 Gene

  • Lung(4.3)
  • Intestine(4.2)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with SLC35D2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35D2 Gene

Orthologs for SLC35D2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35D2 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia SLC35D2 33 34
  • 91.48 (n)
dog
(Canis familiaris)
Mammalia SLC35D2 33 34
  • 91.48 (n)
rat
(Rattus norvegicus)
Mammalia Slc35d2 33
  • 88.03 (n)
mouse
(Mus musculus)
Mammalia Slc35d2 33 16 34
  • 87.72 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35D2 34
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35D2 33
  • 72.63 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35D2 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35d2 33
  • 66.34 (n)
Str.16667 33
zebrafish
(Danio rerio)
Actinopterygii slc35d2 34
  • 64 (a)
OneToOne
LOC100534928 33
  • 63.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta frc 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sqv-7 34
  • 46 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
OneToMany
Species where no ortholog for SLC35D2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35D2 Gene

ENSEMBL:
Gene Tree for SLC35D2 (if available)
TreeFam:
Gene Tree for SLC35D2 (if available)

Paralogs for SLC35D2 Gene

Paralogs for SLC35D2 Gene

(1) SIMAP similar genes for SLC35D2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC35D2: view

Variants for SLC35D2 Gene

Sequence variations from dbSNP and Humsavar for SLC35D2 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000045802 -- 96,315,437(-) T/G genic_downstream_transcript_variant, intron_variant
rs1000159661 -- 96,318,708(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000175627 -- 96,331,412(-) A/C intron_variant
rs1000195011 -- 96,358,801(-) C/A intron_variant
rs1000264375 -- 96,365,396(-) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35D2 Gene

Variant ID Type Subtype PubMed ID
esv3621163 CNV loss 21293372
esv3891694 CNV loss 25118596
nsv1125972 CNV tandem duplication 24896259
nsv1147999 OTHER inversion 26484159

Variation tolerance for SLC35D2 Gene

Residual Variation Intolerance Score: 44.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.70; 46.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35D2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35D2 Gene

Disorders for SLC35D2 Gene

Additional Disease Information for SLC35D2

No disorders were found for SLC35D2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35D2 Gene

Publications for SLC35D2 Gene

  1. Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family. (PMID: 15607426) Ishida N … Sanai Y (Genomics 2005) 2 3 4 22 58
  2. Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection. (PMID: 15082721) Suda T … Nishihara S (The Journal of biological chemistry 2004) 3 4 22 58
  3. Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway. (PMID: 9927678) Herman T … Horvitz HR (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 58
  4. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PMID: 23793025) Anttila V … Palotie A (Nature genetics 2013) 3 58
  5. Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study. (PMID: 23144319) Lee Y … Lee JS (Carcinogenesis 2013) 3 58

Products for SLC35D2 Gene

Sources for SLC35D2 Gene

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