Aliases for SLC35D2 Gene
External Ids for SLC35D2 Gene
Previous GeneCards Identifiers for SLC35D2 Gene
Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC35D2 Gene
SLC35D2 (Solute Carrier Family 35 Member D2) is a Protein Coding gene. Among its related pathways are Keratan sulfate/keratin metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35D1.
UniProtKB/Swiss-Prot for SLC35D2 Gene
Antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling.