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Aliases for SLC35C2 Gene

Aliases for SLC35C2 Gene

  • Solute Carrier Family 35 Member C2 2 3 5
  • Solute Carrier Family 35 (GDP-Fucose Transporter), Member C2 2 3
  • Ovarian Cancer-Overexpressed Gene 1 Protein 3 4
  • C20orf5 3 4
  • OVCOV1 3 4
  • Solute Carrier Family 35, Member C2 2
  • Ovarian Cancer Overexpressed 1 2
  • BA394O2.1 3
  • CGI-15 3

External Ids for SLC35C2 Gene

Previous HGNC Symbols for SLC35C2 Gene

  • C20orf5
  • OVCOV1

Previous GeneCards Identifiers for SLC35C2 Gene

  • GC20M045616
  • GC20M045663
  • GC20M044411
  • GC20M044978
  • GC20M041719

Summaries for SLC35C2 Gene

Entrez Gene Summary for SLC35C2 Gene

  • This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35C2 Gene

SLC35C2 (Solute Carrier Family 35 Member C2) is a Protein Coding gene. Diseases associated with SLC35C2 include Ovarian Cancer.

UniProtKB/Swiss-Prot for SLC35C2 Gene

  • May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.

Gene Wiki entry for SLC35C2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35C2 Gene

Genomics for SLC35C2 Gene

Regulatory Elements for SLC35C2 Gene

Enhancers for SLC35C2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F046410 1.1 Ensembl ENCODE 12.7 -46.7 -46658 1.1 PKNOX1 SIN3A ARID4B ZNF48 RAD21 GLIS2 ZNF143 ZNF654 MXD4 REST ZSWIM1 ELMO2 SLC35C2 NCOA5 LOC105372633
GH20F046398 1 FANTOM5 ENCODE 12.6 -36.8 -36803 5.1 TBP MXI1 MAX EED MAFK HLF BHLHE40 USF2 JUNB CEBPB ELMO2 SLC35C2 CD40 LOC105372633 GC20M046352
GH20F046107 1.6 FANTOM5 Ensembl ENCODE 5.5 +255.9 255918 1.3 ATF1 CREB3L1 WRNIP1 ARID4B DMAP1 SLC30A9 ZNF143 ZMIZ1 SP3 NFYC CD40 SLC2A10 SPATA25 NEURL2 SLC12A5 ENSG00000204044 WFDC3 RPL13P2 SLC35C2 ZNF335
GH20F046394 0.6 Ensembl ENCODE 12.9 -30.7 -30743 0.8 RFX1 SLC35C2 ELMO2 LOC105372633 GC20M046352
GH20F046361 1.1 ENCODE 5.2 +0.3 308 6.0 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 CD40 NCOA5 PCIF1 TP53RK ENSG00000204044 SLC12A5 ELMO2 ENSG00000271984 ZNF335 SLC35C2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35C2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35C2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001449188 158 1801 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143

Genomic Location for SLC35C2 Gene

Chromosome:
20
Start:
46,345,980 bp from pter
End:
46,364,458 bp from pter
Size:
18,479 bases
Orientation:
Minus strand

Genomic View for SLC35C2 Gene

Genes around SLC35C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35C2 Gene

Proteins for SLC35C2 Gene

  • Protein details for SLC35C2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NQQ7-S35C2_HUMAN
    Recommended name:
    Solute carrier family 35 member C2
    Protein Accession:
    Q9NQQ7
    Secondary Accessions:
    • B7Z6V6
    • E1P5T0
    • Q53GK3
    • Q5JW05
    • Q96CJ8
    • Q9Y304

    Protein attributes for SLC35C2 Gene

    Size:
    365 amino acids
    Molecular mass:
    40432 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27724.1; Type=Frameshift; Positions=168, 211, 305; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35C2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35C2 Gene

Post-translational modifications for SLC35C2 Gene

  • Glycosylation at Asn 102
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC35C2 Gene

Domains & Families for SLC35C2 Gene

Gene Families for SLC35C2 Gene

Protein Domains for SLC35C2 Gene

Suggested Antigen Peptide Sequences for SLC35C2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NQQ7

UniProtKB/Swiss-Prot:

S35C2_HUMAN :
  • Belongs to the TPT transporter family. SLC35C subfamily.
Family:
  • Belongs to the TPT transporter family. SLC35C subfamily.
genes like me logo Genes that share domains with SLC35C2: view

Function for SLC35C2 Gene

Molecular function for SLC35C2 Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells.
UniProtKB/Swiss-Prot Induction:
In hypoxic trophoblast cells.
genes like me logo Genes that share phenotypes with SLC35C2: view

Animal Model Products

miRNA for SLC35C2 Gene

miRTarBase miRNAs that target SLC35C2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35C2 Gene

Localization for SLC35C2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35C2 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane. Endoplasmic reticulum-Golgi intermediate compartment membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35C2 gene
Compartment Confidence
golgi apparatus 5
nucleus 4
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 20837470
GO:0005794 Golgi apparatus IEA --
GO:0005801 cis-Golgi network IDA 20837470
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

Pathways & Interactions for SLC35C2 Gene

SuperPathways for SLC35C2 Gene

No Data Available

Interacting Proteins for SLC35C2 Gene

Gene Ontology (GO) - Biological Process for SLC35C2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0010629 negative regulation of gene expression IEA --
GO:0015786 UDP-glucose transport IBA --
GO:0036065 fucosylation IEA --
GO:0036066 protein O-linked fucosylation IEA --
genes like me logo Genes that share ontologies with SLC35C2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35C2 Gene

Transcripts for SLC35C2 Gene

Unigene Clusters for SLC35C2 Gene

Solute carrier family 35, member C2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35C2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c ·
SP1: - - - - - - - -
SP2: - -
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -
SP9: - -
SP10: - - - - - - - - - - - - - - - - - - - -
SP11: -
SP12:
SP13:
SP14: - - - - - - - -
SP15: - - - - - -
SP16: - - -
SP17: - -
SP18: - -
SP19: - - - - - -
SP20: - - - - - -
SP21: - - - -
SP22: - - - - - -
SP23: - - -
SP24: -
SP25: - - -
SP26: -
SP27:
SP28: - - - -
SP29: - -

ExUns: 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e ^ 12a · 12b ^ 13a · 13b · 13c · 13d · 13e ^ 14a · 14b ^ 15a · 15b
SP1: - - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - -
SP10: - - - - -
SP11: - - - -
SP12: - - -
SP13: -
SP14:
SP15:
SP16:
SP17: -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29:

Relevant External Links for SLC35C2 Gene

GeneLoc Exon Structure for
SLC35C2
ECgene alternative splicing isoforms for
SLC35C2

Expression for SLC35C2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC35C2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35C2 Gene

This gene is overexpressed in Cervix (32.6) and Spleen (31.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35C2 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC35C2 Gene:

SLC35C2

SOURCE GeneReport for Unigene cluster for SLC35C2 Gene:

Hs.593344

mRNA Expression by UniProt/SwissProt for SLC35C2 Gene:

Q9NQQ7-S35C2_HUMAN
Tissue specificity: Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer.
genes like me logo Genes that share expression patterns with SLC35C2: view

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for SLC35C2 Gene

Orthologs for SLC35C2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35C2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35C2 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia SLC35C2 34 35
  • 92.28 (n)
dog
(Canis familiaris)
Mammalia SLC35C2 34 35
  • 91.6 (n)
rat
(Rattus norvegicus)
Mammalia Slc35c2 34
  • 88.92 (n)
mouse
(Mus musculus)
Mammalia Slc35c2 34 16 35
  • 88.37 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35C2 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35C2 34 35
  • 72.35 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35C2 35
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6085 34
zebrafish
(Danio rerio)
Actinopterygii slc35c2 34
  • 66.28 (n)
Dr.7973 34
fruit fly
(Drosophila melanogaster)
Insecta CG14971 34 35
  • 55.48 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005537 34
  • 54.88 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y47G6A.7 34
  • 47.67 (n)
Y47G6A.7 35
  • 33 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR462C 34
  • 46.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YMD8 34 35 37 37
  • 44.41 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10131g 34
  • 43.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G06470 34
  • 45.86 (n)
rice
(Oryza sativa)
Liliopsida Os01g0749900 34
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4074 35
  • 55 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC22E12.01 34
  • 42.32 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8485 34
Species where no ortholog for SLC35C2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC35C2 Gene

ENSEMBL:
Gene Tree for SLC35C2 (if available)
TreeFam:
Gene Tree for SLC35C2 (if available)

Paralogs for SLC35C2 Gene

Pseudogenes.org Pseudogenes for SLC35C2 Gene

genes like me logo Genes that share paralogs with SLC35C2: view

No data available for Paralogs for SLC35C2 Gene

Variants for SLC35C2 Gene

Sequence variations from dbSNP and Humsavar for SLC35C2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs10084527 -- 46,356,118(+) CTCGG(C/G)AGAGC intron-variant
rs10211808 -- 46,357,125(+) CCCTC(G/T)GGCCA intron-variant
rs1044369 -- 46,358,679(-) ACTCT(C/G)CCTGG intron-variant, nc-transcript-variant, utr-variant-5-prime
rs111743887 -- 46,366,333(+) TAACG(-/T)TATGT upstream-variant-2KB, utr-variant-3-prime
rs111746264 -- 46,358,459(+) AGGGT(C/T)AACAC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35C2 Gene

Variant ID Type Subtype PubMed ID
nsv586155 CNV loss 21841781
nsv1057686 CNV loss 25217958
esv2722457 CNV deletion 23290073

Variation tolerance for SLC35C2 Gene

Residual Variation Intolerance Score: 26.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35C2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35C2 Gene

Disorders for SLC35C2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC35C2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • malignant ovarian tumor
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC35C2

Genetic Association Database (GAD)
SLC35C2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35C2
genes like me logo Genes that share disorders with SLC35C2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC35C2 Gene

Publications for SLC35C2 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Slc35c2 promotes Notch1 fucosylation and is required for optimal Notch signaling in mammalian cells. (PMID: 20837470) Lu L. … Stanley P. (J. Biol. Chem. 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Identification, molecular characterization, and tissue expression of OVCOV1. (PMID: 12461647) Leach R.E. … Krawetz S.A. (Mamm. Genome 2002) 3 4 64

Products for SLC35C2 Gene

Sources for SLC35C2 Gene

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