SLC35B4 Gene
protein-coding GIFtS: 48
GCID: GC07M133974
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|
solute carrier family 35, member B4
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Aliases for SLC35B4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member B41 2 | | YEA2 | | YEA41 2 3 | | UDP-Xylose And UDP-N-Acetylglucosamine Transporter2 | | YEA4 Homolog2 3 | | UDP-Xylose/N-Acetylglucosamine Transporter2 | | FLJ146971 | | Solute Carrier Family 35 Member B43 |
Export aliases for SLC35B4 gene to outside databasesPrevious GC identifers: GC07M133377 GC07M133394 GC07M133435 GC07M133624 GC07M128275 |
Summaries for SLC35B4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for SLC35B4: Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, tothe Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikovet al., 2005 (PubMed 15911612)).(supplied by OMIM, Mar 2008) UniProtKB/Swiss-Prot: S35B4_HUMAN, Q969S0Function: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) andUDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi Gene Wiki entry for SLC35B4
|
Genomic Views for SLC35B4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007933.15 NT_079596.2
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the SLC35B4 gene promoter: AML1a FOXD3 CUTL1 GATA-1 GATA-2 PPAR-alpha POU2F1 POU2F1a Cart-1 Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35B4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35B4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q33 Ensembl cytogenetic band: 7q33 HGNC cytogenetic band: 7q33SLC35B4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M133974: view genomic region
(about GC identifiers)
Start:
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133,974,084 bp from pter |
End:
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134,001,827 bp from pter |
Size:
|
27,744 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 133,318,463-133,346,213 |
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Proteins for SLC35B4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: S35B4_HUMAN, Q969S0 (See
protein sequence)Recommended Name: UDP-xylose and UDP-N-acetylglucosamine transporter Size: 331 amino acids; 37424 Da
Subcellular location: Golgi apparatus membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB55325.1; Type=Erroneous initiation;
Secondary accessions: A4D1P3 A6NNS4 Q53GQ7 Q8TCU7 Q96K33Alternative splicing: 3 isoforms: Q969S0-1 Q969S0-2 Q969S0-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for SLC35B4: NX_Q969S0
SLC35B4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116215.1 ENSEMBL proteins: ENSP00000367770 ENSP00000405445 Reactome Protein details: Q969S0 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
SLC35B4 for ontologies About GeneDecksing
SLC35B4 Antibody Products: Assay Products for SLC35B4: |
Protein
Domains / Families for SLC35B4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35B4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q969S0ProtoNet protein and cluster: Q969S0 UniProtKB/Swiss-Prot: S35B4_HUMAN, Q969S0Similarity: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily |
Function for SLC35B4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: S35B4_HUMAN, Q969S0Function: Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) andUDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35B4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35B4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC35B4 (NM_032826) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35B4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B4 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005462 | UDP-N-acetylglucosamine transmembrane transporter activity |
IDA | 15911612 | | GO:0005464 | UDP-xylose transmembrane transporter activity |
IDA | 15911612 |
SLC35B4 for ontologies About GeneDecksing
|
Pathways & Interactions for SLC35B4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Transport of nucleotide sugars | | | 3 | Transport of organic anions | |
Pathway sources See GeneCards unified pathways Show all pathways
4
Reactome Pathways for SLC35B4
SLC35B4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35B4
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
 2 Interacting proteins for SLC35B4 (Q969S03 ENSP000003677704) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
SLC35B4 for ontologies About GeneDecksing
|
Drugs & Compounds for SLC35B4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for SLC35B4 Search CenterWatch for drugs/clinical trials and news about SLC35B4 / S35B4 
|
Transcripts for SLC35B4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for SLC35B4 gene: NM_032826.4 Unigene Cluster for SLC35B4: Solute carrier family 35, member B4 Hs.490181 [show with all ESTs]Unigene Representative Sequence: NM_0328264 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378509(uc003vrn.3 uc010lmk.3) ENST00000416907 ENST00000466599 ENST00000470969(uc003vro.4)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35B4 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35B4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC35B4 (NM_032826) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35B4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B4  |
Additional cDNA sequence: AB052892.1 AJ315497.1 AJ315498.1 AJ971941.1 AK027603.1 AK027726.1 AK056475.1 AK075368.1 AK222874.1 AK307621.1 BC008413.1 10 DOTS entries: DT.404214 DT.442155 DT.100695906 DT.99934908 DT.121046842 DT.100749917 DT.95163286 DT.100749916 DT.121046840 DT.95163287 24/169 AceView cDNA sequences (see all 169): BM706351 Z41039 AV651976 AI379300 AK027603 AI418933 CB135948 T19390 AU184907 AJ315498 AA301392 AA464839 BP372821 AI360052 AV647046 AA837772 AI422809 AA207198 AA252046 AA625377 BQ431120 AK075368 AK027726 BM720096 GeneLoc Exon Structure
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Expression for SLC35B4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35B4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TCTTACTCAT
About this image See SLC35B4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for SLC35B4
SOURCE GeneReport for Unigene cluster: Hs.490181 SABiosciences Custom PCR Arrays for SLC35B4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35B4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC35B4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35B4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35B4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B4 |
Orthologs for SLC35B4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for SLC35B4 gene from 6/23 species (see all 23) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Slc35b41 , 5 |
solute carrier family 35, member B41, 5 |
88.92(n)1 90.94(a)1 |
  |
6 (14.75 cM)5 582461 NM_021435.31 NP_067410.11 341533805 |
chicken (Gallus gallus) |
Aves |
SLC35B41 |
solute carrier family 35, member B4 |
76.67(n) 81.52(a) |
  |
416698 XM_414994.3 XP_414994.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.21872 |
Danio rerio mRNA similar to hypothetical protein, MNCb-4414 more |
76.34(n) |
  |
BC045293.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Efr1 |
ER GDP-fucose transporter |
58.25(n) 54.89(a) |
  |
31553 NM_132071.2 NP_572299.1 |
worm (Caenorhabditis elegans) |
Secernentea |
nstp-21 |
Protein NSTP-2 |
50.75(n) 42.63(a) |
  |
177424 NM_001047471.4 NP_001040936.1 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
YEA4(YEL004W)4 YEA41 |
Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) more4 Yea4p1 |
43.36(n)1 31.05(a)1 |
  |
5(146951-147979)4 8567141, 4 NP_010912.11, 4 |
ENSEMBL Gene Tree for SLC35B4 (if available) TreeFam Gene Tree for SLC35B4 (if available)  |
Paralogs for SLC35B4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for SLC35B4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 7 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35B4 (133974084 - 134001827 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for SLC35B4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35B4 |
|
Disorders
/ Diseases for SLC35B4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35B4 for disorders About GeneDecksing
OMIM gene information: 610923
OMIM disorders: --
2 diseases for SLC35B4: About MalaCardst cell deficiency obesity Human Genome Epidemiology (HuGE) Navigator: SLC35B4 (2 documents) Export disorders for SLC35B4 gene to outside databases
|
Publications for SLC35B4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35B4 gene, integrated from 9 sources (see all 13): (articles sorted by number of sources associating them with SLC35B4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The human solute carrier gene SLC35B4 encodes a bifunctional nucleotide sugar transporter with specificity for UDP-xylose and UDP- N-acetylglucosamine. (PubMed id 15911612)1, 2 Ashikov A.... Bakker H. (2005)
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- Deep congenic analysis identifies many strong, contex t-dependent QTLs, one of which, Slc35b4, regulates obesity and glucose homeosta sis. (PubMed id 21507882)1 Yazbek S.N....Nadeau J.H. (2011)
- Subcellular localization of UDP-GlcNAc, UDP-Gal and SL C35B4 transporters. (PubMed id 21918738)1 Maszczak-Seneczko D....Olczak M. (2011)
- Molecular and functional characterization of microsomal UDP-glucuronic acid uptake by members of the nucleotide sugar transporter (NST) family. (PubMed id 16965264)1 Kobayashi T....Burchell B. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
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External Searches for SLC35B4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC35B4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35B4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35B4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for SLC35B4 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
|
| | |
About This Section
| Patent Information for SLC35B4 gene: Search GeneIP for patents involving SLC35B4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for SLC35B4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35B4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35B4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35B4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35B4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35B4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35B4 |
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 | | SLC35B4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B4 |
|  |  |  | | | ThermoFisher Antibodies for SLC35B4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B4 |
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