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Aliases for SLC35B3 Gene

Aliases for SLC35B3 Gene

  • Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate Transporter), Member B3 2
  • PAPST2 3 4 6
  • Solute Carrier Family 35 (Adenosine 3-Phospho 5-Phosphosulfate Transporter), Member B3 2 3
  • 3 Phosphoadenosine 5 Phosphosulfate Transporter 2 2 3
  • Solute Carrier Family 35, Member B3 2 3
  • PAPS Transporter 2 3 4
  • C6orf196 3 4
  • Adenosine 3-Phospho 5-Phosphosulfate Transporter 2 3
  • 3-Phosphoadenosine 5-Phosphosulfate Transporter 4
  • Chromosome 6 Open Reading Frame 196 2
  • Solute Carrier Family 35 Member B3 4
  • CGI-19 3

External Ids for SLC35B3 Gene

Previous Symbols for SLC35B3 Gene

  • C6orf196

Summaries for SLC35B3 Gene

Entrez Gene Summary for SLC35B3 Gene

  • This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for SLC35B3 Gene

SLC35B3 (Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate Transporter), Member B3) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot for SLC35B3 Gene

  • Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B3 Gene

Genomics for SLC35B3 Gene

Genomic Location for SLC35B3 Gene

Start:
8,413,067 bp from pter
End:
8,435,567 bp from pter
Size:
22,501 bases
Orientation:
Minus strand

Genomic View for SLC35B3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B3 Gene

Regulatory Elements for SLC35B3 Gene

Proteins for SLC35B3 Gene

  • Protein details for SLC35B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1N7-S35B3_HUMAN
    Recommended name:
    Adenosine 3-phospho 5-phosphosulfate transporter 2
    Protein Accession:
    Q9H1N7
    Secondary Accessions:
    • A6NKX9
    • Q1XH11
    • Q6MZJ0
    • Q7Z662
    • Q9Y308

    Protein attributes for SLC35B3 Gene

    Size:
    401 amino acids
    Molecular mass:
    44593 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27728.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAE46041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B3 Gene

Proteomics data for SLC35B3 Gene at MOPED

Post-translational modifications for SLC35B3 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn12, Asn71, and Asn254

Other Protein References for SLC35B3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC35B3 Gene

Domains for SLC35B3 Gene

Gene Families for SLC35B3 Gene

Protein Domains for SLC35B3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

S35B3_HUMAN
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.:
    • Q9H1N7
genes like me logo Genes that share domains with SLC35B3: view

Function for SLC35B3 Gene

Molecular function for SLC35B3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=2.2 uM for PAPS {ECO:0000269 PubMed:16492677};
UniProtKB/Swiss-Prot Function: Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.

Phenotypes for SLC35B3 Gene

genes like me logo Genes that share phenotypes with SLC35B3: view

miRNA for SLC35B3 Gene

miRTarBase miRNAs that target SLC35B3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC35B3 Gene

Localization for SLC35B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35B3 Gene COMPARTMENTS Subcellular localization image for SLC35B3 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with SLC35B3: view

Pathways for SLC35B3 Gene

genes like me logo Genes that share pathways with SLC35B3: view

Pathways by source for SLC35B3 Gene

Interacting Proteins for SLC35B3 Gene

Gene Ontology (GO) - Biological Process for SLC35B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0005975 carbohydrate metabolic process TAS --
GO:0006805 xenobiotic metabolic process TAS --
GO:0030203 glycosaminoglycan metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with SLC35B3: view

Compounds for SLC35B3 Gene

(3) HMDB Compounds for SLC35B3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
58-61-7
Adenosine phosphosulfate
  • Adenosine Phosphosulfate
485-84-7
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7
genes like me logo Genes that share compounds with SLC35B3: view

Transcripts for SLC35B3 Gene

Unigene Clusters for SLC35B3 Gene

Solute carrier family 35, member B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - -
SP18: -

ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SLC35B3 Gene

GeneLoc Exon Structure for
SLC35B3
ECgene alternative splicing isoforms for
SLC35B3

Expression for SLC35B3 Gene

mRNA expression in normal human tissues for SLC35B3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC35B3 Gene

SOURCE GeneReport for Unigene cluster for SLC35B3 Gene Hs.285847

mRNA Expression by UniProt/SwissProt for SLC35B3 Gene

Q9H1N7-S35B3_HUMAN
Tissue specificity: Preferentially and highly expressed in colon.
genes like me logo Genes that share expressions with SLC35B3: view

Orthologs for SLC35B3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B3 36
  • 99.5 (n)
  • 99.5 (a)
SLC35B3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35B3 36
  • 90.89 (n)
  • 90.98 (a)
SLC35B3 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC607290 36
  • 92.65 (n)
  • 92.23 (a)
SLC35B3 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b3 36
  • 84.68 (n)
  • 86.11 (a)
Slc35b3 16
Slc35b3 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35B3 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35B3 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b3 36
  • 84 (n)
  • 86.25 (a)
chicken
(Gallus gallus)
Aves SLC35B3 36
  • 81.93 (n)
  • 88.89 (a)
SLC35B3 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B3 37
  • 89 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ernst 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b3 36
  • 75.79 (n)
  • 83.42 (a)
Str.3298 36
zebrafish
(Danio rerio)
Actinopterygii slc35b3 36
  • 72.27 (n)
  • 83.2 (a)
slc35b3 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta S35B3_ANOGA 36
  • 55.69 (n)
  • 60.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta Papst2 36
  • 56.36 (n)
  • 57.51 (a)
Papst2 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pst-2 36
  • 56.56 (n)
  • 52.81 (a)
pst-2 37
  • 48 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 37
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12600 36
  • 49.33 (n)
  • 38.33 (a)
rice
(Oryza sativa)
Liliopsida Os03g0118200 36
  • 48.14 (n)
  • 38.49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 51 (a)
OneToOne
Species with no ortholog for SLC35B3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B3 Gene

ENSEMBL:
Gene Tree for SLC35B3 (if available)
TreeFam:
Gene Tree for SLC35B3 (if available)

Paralogs for SLC35B3 Gene

Paralogs for SLC35B3 Gene

genes like me logo Genes that share paralogs with SLC35B3: view

Variants for SLC35B3 Gene

Sequence variations from dbSNP and Humsavar for SLC35B3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15300 -- 8,413,179(+) TCAAA(A/G)TGGAA utr-variant-3-prime, nc-transcript-variant
rs1034274 -- 8,422,912(-) AAAAA(A/C)AAAAC intron-variant
rs1034275 -- 8,421,217(-) CATTA(A/C)TCTGG intron-variant
rs1034276 -- 8,421,214(-) TAATC(C/T)GGTTA intron-variant
rs1034277 -- 8,421,187(-) ACTAC(A/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B3 Gene

Variant ID Type Subtype PubMed ID
nsv830584 CNV Loss 17160897
nsv823418 CNV Loss 20364138
esv2656617 CNV Deletion 23128226
esv2731548 CNV Deletion 23290073

Relevant External Links for SLC35B3 Gene

HapMap Linkage Disequilibrium report
SLC35B3

Disorders for SLC35B3 Gene

No disorders were found for SLC35B3 Gene.

No data available for UniProtKB/Swiss-Prot for SLC35B3 Gene

Publications for SLC35B3 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. (PMID: 16492677) Kamiyama S. … Nishihara S. (J. Biol. Chem. 2006) 3 4
  5. Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (PMID: 16793546) Goren A. … Ast G. (Mol. Cell 2006) 3

Products for SLC35B3 Gene

Sources for SLC35B3 Gene

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