Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC35B3 Gene

protein-coding   GIFtS: 49
GCID: GC06M008358

Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate...

(Previous names: chromosome 6 open reading frame 196, solute carrier family...)
(Previous symbol: C6orf196)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate
Transporter), Member B31 2
     PAPS Transporter 22 3
C6orf1961 2 3     Chromosome 6 Open Reading Frame 1961
PAPST22 3 5     Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 22
Solute Carrier Family 35, Member B31 2     3'-Phosphoadenosine 5'-Phosphosulfate Transporter3
3' Phosphoadenosine 5' Phosphosulfate Transporter 21 2     Solute Carrier Family 35 Member B33

External Ids:    HGNC: 216011   Entrez Gene: 510002   Ensembl: ENSG000001247867   OMIM: 6108455   UniProtKB: Q9H1N73   

Export aliases for SLC35B3 gene to outside databases

Previous GC identifers: GC06M008401 GC06M008290


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC35B3 Gene:
This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime
phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has
been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple
transcript variants. (provided by RefSeq, Dec 2013)

GeneCards Summary for SLC35B3 Gene:
SLC35B3 (solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3) is a protein-coding gene. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot: S35B3_HUMAN, Q9H1N7
Function: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS
is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient
expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC35B3 gene promoter:
         ISGF-3   RFX1   SREBP-1c   ATF-2   STAT5A   POU6F1 (c2)   RORalpha2   SREBP-1b   SRY   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35B3 promoter sequence
   Search Chromatin IP Primers for SLC35B3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35B3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p24.3   Ensembl cytogenetic band:  6p24.3   HGNC cytogenetic band: 6p24.3

SLC35B3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35B3 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M008358:  view genomic region     (about GC identifiers)

Start:
8,413,301 bp from pter      End:
8,435,794 bp from pter
Size:
22,494 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: S35B3_HUMAN, Q9H1N7 (See protein sequence)
Recommended Name: Adenosine 3'-phospho 5'-phosphosulfate transporter 2  
Size: 401 amino acids; 44593 Da
Sequence caution: Sequence=AAD27728.1; Type=Frameshift; Positions=Several; Sequence=CAE46041.1; Type=Erroneous
initiation;
Secondary accessions: A6NKX9 Q1XH11 Q6MZJ0 Q7Z662 Q9Y308
Alternative splicing: 3 isoforms:  Q9H1N7-1   Q9H1N7-2   Q9H1N7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35B3: NX_Q9H1N7

Explore proteomics data for SLC35B3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn12, Asn71, Asn254
  • Modification sites at PhosphoSitePlus

  • See SLC35B3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001136013.1  NP_057032.2  

    ENSEMBL proteins: 
     ENSP00000368981   ENSP00000345902   ENSP00000389438  
    Reactome Protein details: Q9H1N7

    SLC35B3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC35B3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC35B3
    GenScript Custom Purified and Recombinant Proteins Services for SLC35B3
    Novus Biologicals SLC35B3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC35B3

     
    Search eBioscience for Proteins for SLC35B3 

    SLC35B3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC35B3
    Search for Antibodies for SLC35B3 at Abcam
    Cloud-Clone Corp. Antibodies for SLC35B3
    Search ThermoFisher Antibodies for SLC35B3
    Search LSBio for Antibodies for SLC35B3

    SLC35B3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC35B3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC35B3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC35B3
    Cloud-Clone Corp. CLIAs for SLC35B3
    Search eBioscience for ELISAs for SLC35B3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAPS transporter 2
    SLC35 family of nucleotide sugar transporters

    1 InterPro protein domain:
     IPR013657 UAA

    Graphical View of Domain Structure for InterPro Entry Q9H1N7

    ProtoNet protein and cluster: Q9H1N7

    1 Blocks protein domain: IPB013657 UAA transporter

    UniProtKB/Swiss-Prot: S35B3_HUMAN, Q9H1N7
    Similarity: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily


    Find genes that share domains with SLC35B3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35B3_HUMAN, Q9H1N7
    Function: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS
    is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient
    expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon
    Biophysicochemical properties: Kinetic parameters: KM=2.2 uM for PAPS;

    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC35B3:

     Decreased homologous recombina  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35B3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC35B3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC35B3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC35B3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC35B3:
    hsa-mir-16-5p (MIRT000907), hsa-mir-15a-5p (MIRT000908)

    Block miRNA regulation of human, mouse, rat SLC35B3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SLC35B3:
    hsa-miR-205 hsa-miR-9 hsa-miR-659 hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSLC35B3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC35B3
    Predesigned siRNA for gene silencing in human, mouse, rat SLC35B3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC35B3

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC35B3 (see all 17)
    OriGene ORF clones in mouse, rat for SLC35B3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC35B3 (NM_001142540)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC35B3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC35B3
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC35B3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    S35B3_HUMAN, Q9H1N7: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    mitochondrion2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005739mitochondrion IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC35B3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC35B3 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Biological oxidations
    Biological oxidations0.56
    Cytosolic sulfonation of small molecules0.00
    Phase II conjugation0.56
    Transport and synthesis of PAPS0.00
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    4Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of nucleotide sugars0.00
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SLC35B3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC35B3
        Transport and synthesis of PAPS
    Transport of nucleotide sugars


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35B3
    Interactions:

        Search GeneGlobe Interaction Network for SLC35B3

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0044281small molecule metabolic process TAS--
    GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process TAS--

    Find genes that share ontologies with SLC35B3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC35B3 (S35B3)

    3 HMDB Compounds for SLC35B3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine phosphosulfateAdenosine Phosphosulfate (see all 13)485-84-7--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC35B3 gene (3 alternative transcripts): 
    NM_001142540.1  NM_001142541.2  NM_015948.4  

    Unigene Cluster for SLC35B3:

    Solute carrier family 35, member B3
    Hs.285847  [show with all ESTs]
    Unigene Representative Sequence: NM_015948
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379660(uc003myc.3 uc010joe.3 uc003myb.3 uc011did.2 uc003myd.3)
    ENST00000339306(uc010jof.2) ENST00000426876(uc011die.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC35B3 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate SLC35B3:
    hsa-miR-205 hsa-miR-9 hsa-miR-659 hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidSLC35B3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC35B3
    Predesigned siRNA for gene silencing in human, mouse, rat SLC35B3
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC35B3 (see all 17)
    OriGene ORF clones in mouse, rat for SLC35B3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC35B3 (NM_001142540)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC35B3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC35B3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC35B3
      QuantiTect SYBR Green Assays in human, mouse, rat SLC35B3
      QuantiFast Probe-based Assays in human, mouse, rat SLC35B3

    Additional mRNA sequence: 

    AB231931.1 AF132953.1 AK303940.1 AK304250.1 AK309222.1 AK313522.1 BC006973.1 

    18 DOTS entries:

    DT.101983397  DT.413685  DT.95274431  DT.91829337  DT.206574  DT.75137613  DT.91656258  DT.121343652 
    DT.121343661  DT.121343664  DT.413686  DT.92066643  DT.100787754  DT.121343653  DT.121343660  DT.91957253 
    DT.95274432  DT.100787756 

    Selected AceView cDNA sequences (see all 188):

    BM996988 BQ773203 BQ012121 AA829995 AA831190 BQ774560 BE220680 CR605449 
    AA399961 CA413498 BX647208 AI445162 AI680140 AI686988 AI299914 AI420298 
    AA229477 AA618518 CR626516 BX480900 CA449678 AA905855 BU674901 CA449792 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B3 (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^
    SP1:                                      -     -           -     -     -     -                             -     -                 -     -                     
    SP2:                                            -           -     -     -     -                             -     -                 -     -                     
    SP3:                                                  -     -     -     -     -                             -     -                 -     -     -     -     -   
    SP4:                                                                                                        -     -                 -     -                     
    SP5:                                -     -     -           -     -     -     -                             -     -                 -     -                     

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18
    SP1:                                            -         
    SP2:              -                             -         
    SP3:              -                             -         
    SP4:              -                             -         
    SP5:                                                      


    ECgene alternative splicing isoforms for SLC35B3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC35B3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTGCAAGA
    SLC35B3 Expression
    About this image

    SLC35B3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC35B3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.285847

    UniProtKB/Swiss-Prot: S35B3_HUMAN, Q9H1N7
    Tissue specificity: Preferentially and highly expressed in colon

        Custom PCR Arrays for SLC35B3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC35B3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC35B3
    QuantiTect SYBR Green Assays in human, mouse, rat SLC35B3
    QuantiFast Probe-based Assays in human, mouse, rat SLC35B3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC35B3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35b31 , 5 solute carrier family 35, member B31, 5 84.68(n)1
    86.11(a)1
      13 (18.61 cM)5
    1086521  NM_001170431.11  NP_001163902.11 
     389321405 
    chicken
    (Gallus gallus)
    Aves SLC35B31 solute carrier family 35, member B3 81.93(n)
    88.89(a)
      420863  XM_418952.3  XP_418952.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35B36
    solute carrier family 35 (adenosine 3'-phospho 5'-...
    89(a)
    1 ↔ 1
    GL343209.1(1199661-1229185)
    African clawed frog
    (Xenopus laevis)
    Amphibia ernst2 putative multispan transmembrane protein 76.94(n)    AJ489472.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc35b31 solute carrier family 35, member B3 72.27(n)
    83.2(a)
      664769  NM_001039995.1  NP_001035084.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Papst21 PAPS transporter 2 56.36(n)
    57.51(a)
      39914  NM_140697.4  NP_648954.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pst-21 pst-2 56.56(n)
    52.81(a)
      175787  NM_001047390.3  NP_001040855.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HUT16
    Protein with a role in UDP-galactose transport to ...
    21(a)
    1 → many
    XVI(87014-88033) YPL244C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G126001 AT1G12600 49.33(n)
    38.33(a)
      837816  NM_101130.2  NP_172720.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g01182001 Os03g0118200 48.14(n)
    38.49(a)
      4331414  NM_001055306.1  NP_001048771.1 


    ENSEMBL Gene Tree for SLC35B3 (if available)
    TreeFam Gene Tree for SLC35B3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC35B3 gene
    SLC35B22  SLC35B12  

    Find genes that share paralogs with SLC35B3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC35B3 (see all 496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49604041,2
    C,F,A,H--8412911(+) ATGGAC/TTGGGA 3 -- ds500115Minor allele frequency- T:0.11NS EA NA WA CSA 1858
    rs1512267281,2
    --8412936(+) AGGATA/GAAACT 3 -- ds50010--------
    rs793132431,2
    C,F--8412953(+) CTGTTC/TCACTT 3 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1933015891,2
    --8413023(+) GGTTCA/GTAACA 3 -- ds50010--------
    rs1160321781,2
    C,F--8413036(+) GTTCCC/TGCTGC 3 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1138939481,2
    --8413055(+) TCTAAC/TGCTGC 3 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1888011111,2
    --8413056(+) CTAACA/GCTGCT 3 -- ds50010--------
    rs1503577671,2
    C--8413127(+) TGTTGC/TGTGGT 3 -- ds50010--------
    rs1463151091,2
    C--8413334(+) TATAA-/TTGAAT 3 -- ut310--------
    rs37992501,2
    H--8413383(+) ATAACA/CGAGAA 3 -- ut314Minor allele frequency- C:0.00NS EA 416

    HapMap Linkage Disequilibrium report for SLC35B3 (8413301 - 8435794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC35B3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731548CNV Deletion23290073
    esv2656617CNV Deletion23128226
    nsv830584CNV Loss17160897
    nsv823418CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35B3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35B3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610845    OMIM disorders: --


    Find genes that share disorders with SLC35B3           About GenesLikeMe


    Export disorders for SLC35B3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC35B3 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with SLC35B3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. (PubMed id 16492677)1, 2 Kamiyama S.... Nishihara S. (J. Biol. Chem. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. (PubMed id 20978009)1 Kamiyama S....Nishihara S. (Glycobiology 2011)
    8. [Specifically up-regulated non-coding RNA gene HULC in tumor cell lines and its effects on the expression of neighboring gene SLC35B3]. (PubMed id 21211351)1 Li D....Zhan Q.M. (Zhonghua Yi Xue Za Zhi 2010)
    9. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51000 HGNC: 21601 AceView: SLC35B3 Ensembl:ENSG00000124786 euGenes: HUgn51000
    ECgene: SLC35B3 H-InvDB: SLC35B3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC35B3 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=SLC35B3

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC35B3 gene:
    Search GeneIP for patents involving SLC35B3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC35B3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for SLC35B3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC35B3  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC35B3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC35B3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC35B3   OriGene Custom Protein Services for SLC35B3  

     
     
     Block miRNA regulation of human, mouse, rat SLC35B3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC35B3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35B3 Predesigned siRNA for gene silencing in human, mouse, rat SLC35B3
     QuantiFast Probe-based Assays in human, mouse, rat SLC35B3 QuantiTect SYBR Green Assays in human, mouse, rat SLC35B3
     Custom PCR Arrays for SLC35B3 Search Chromatin IP Primers for SLC35B3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC35B3  Search GeneGlobe Interaction Network for SLC35B3
     Regulatory tfbs in SLC35B3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC35B3 GenScript cDNA clones with any tag delivered in your preferred vector for SLC35B3
     GenScript Custom Assay Services for SLC35B3 GenScript Custom overexpressing Cell Line Services for SLC35B3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC35B3 (S35B3)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC35B3 lysates
     Search for Antibodies for SLC35B3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC35B3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for SLC35B3
     Antibodies for SLC35B3
     ELISAs for SLC35B3
     CLIAs for SLC35B3



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC35B3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B3
     SwitchGear 3'UTR luciferase reporter plasmids for SLC35B3
     SwitchGear Promoter luciferase reporter plasmids for SLC35B3
     Search ThermoFisher Antibodies for SLC35B3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35B3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35B3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC35B3
     Search LSBio for Antibodies for SLC35B3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC35B3
      Search eBioscience for proteins for SLC35B3
      Search eBioscience for elisas for SLC35B3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC35B3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4