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Aliases for SLC35B3 Gene

Aliases for SLC35B3 Gene

  • Solute Carrier Family 35 Member B3 2 3 4 5
  • Solute Carrier Family 35 (Adenosine 3-Phospho 5-Phosphosulfate Transporter), Member B3 2 3
  • 3 Phosphoadenosine 5 Phosphosulfate Transporter 2 2 3
  • PAPS Transporter 2 3 4
  • C6orf196 3 4
  • PAPST2 3 4
  • Adenosine 3-Phospho 5-Phosphosulfate Transporter 2 3
  • 3-Phosphoadenosine 5-Phosphosulfate Transporter 4
  • Chromosome 6 Open Reading Frame 196 2
  • Solute Carrier Family 35, Member B3 2
  • CGI-19 3

External Ids for SLC35B3 Gene

Previous HGNC Symbols for SLC35B3 Gene

  • C6orf196

Previous GeneCards Identifiers for SLC35B3 Gene

  • GC06M008401
  • GC06M008358
  • GC06M008290

Summaries for SLC35B3 Gene

Entrez Gene Summary for SLC35B3 Gene

  • This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

GeneCards Summary for SLC35B3 Gene

SLC35B3 (Solute Carrier Family 35 Member B3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of vitamins, nucleosides, and related molecules. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot for SLC35B3 Gene

  • Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B3 Gene

Genomics for SLC35B3 Gene

Regulatory Elements for SLC35B3 Gene

Enhancers for SLC35B3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G008433 1.1 ENCODE 7.2 +0.6 600 2.9 HDGF PKNOX1 CREB3L1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 LOC100506207 SLC35B3 GC06P008397
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35B3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35B3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000192887 467 2600 HDGF PKNOX1 CREB3L1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for SLC35B3 Gene

Chromosome:
6
Start:
8,413,067 bp from pter
End:
8,435,567 bp from pter
Size:
22,501 bases
Orientation:
Minus strand

Genomic View for SLC35B3 Gene

Genes around SLC35B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B3 Gene

Proteins for SLC35B3 Gene

  • Protein details for SLC35B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H1N7-S35B3_HUMAN
    Recommended name:
    Adenosine 3-phospho 5-phosphosulfate transporter 2
    Protein Accession:
    Q9H1N7
    Secondary Accessions:
    • A6NKX9
    • Q1XH11
    • Q6MZJ0
    • Q7Z662
    • Q9Y308

    Protein attributes for SLC35B3 Gene

    Size:
    401 amino acids
    Molecular mass:
    44593 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD27728.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=CAE46041.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC35B3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B3 Gene

Post-translational modifications for SLC35B3 Gene

  • Glycosylation at isoforms=2, 312, Asn71, and isoforms=3254
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC35B3 Gene

Domains & Families for SLC35B3 Gene

Gene Families for SLC35B3 Gene

Protein Domains for SLC35B3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35B3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H1N7

UniProtKB/Swiss-Prot:

S35B3_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B3: view

Function for SLC35B3 Gene

Molecular function for SLC35B3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=2.2 uM for PAPS {ECO:0000269 PubMed:16492677};
UniProtKB/Swiss-Prot Function:
Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon.

Gene Ontology (GO) - Molecular Function for SLC35B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046964 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC35B3: view
genes like me logo Genes that share phenotypes with SLC35B3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B3

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B3 Gene

Localization for SLC35B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B3 Gene

Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35B3 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 4
plasma membrane 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC35B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030173 integral component of Golgi membrane IBA --
genes like me logo Genes that share ontologies with SLC35B3: view

Pathways & Interactions for SLC35B3 Gene

genes like me logo Genes that share pathways with SLC35B3: view

Interacting Proteins for SLC35B3 Gene

Gene Ontology (GO) - Biological Process for SLC35B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0050428 3-phosphoadenosine 5-phosphosulfate biosynthetic process TAS --
GO:0055085 transmembrane transport IEA --
GO:1902559 3-phospho-5-adenylyl sulfate transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC35B3: view

No data available for SIGNOR curated interactions for SLC35B3 Gene

Drugs & Compounds for SLC35B3 Gene

(1) Drugs for SLC35B3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine Approved, Investigational Pharma Agonist 419

(2) Additional Compounds for SLC35B3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Adenosine phosphosulfate
  • Adenosine 5'-phosphosulfate
  • Adenosine 5'-phosphosulphate
  • Adenosine 5'-sulphatophosphate
  • Adenosine Phosphosulfate
  • Adenosine Phosphosulphate
485-84-7
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
  • 3'-Phospho-5'-adenylyl sulphate
  • 3'-Phosphoadenosine 5'-phosphosulfate
  • 3'-Phosphoadenosine 5'-phosphosulphate
  • 3'-Phosphoadenosine-5'-phosphosulfate
482-67-7
genes like me logo Genes that share compounds with SLC35B3: view

Transcripts for SLC35B3 Gene

Unigene Clusters for SLC35B3 Gene

Solute carrier family 35, member B3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b · 11c ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: - - - - - - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - - - - - - - - - -
SP12: - - -
SP13:
SP14: - - - -
SP15: - -
SP16: - -
SP17: - - - - - - - -
SP18: -

ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b ^ 18
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for SLC35B3 Gene

GeneLoc Exon Structure for
SLC35B3
ECgene alternative splicing isoforms for
SLC35B3

Expression for SLC35B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35B3 Gene

Protein differential expression in normal tissues from HIPED for SLC35B3 Gene

This gene is overexpressed in Plasma (57.6) and Islet of Langerhans (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC35B3 Gene



Protein tissue co-expression partners for SLC35B3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35B3 Gene:

SLC35B3

SOURCE GeneReport for Unigene cluster for SLC35B3 Gene:

Hs.285847

mRNA Expression by UniProt/SwissProt for SLC35B3 Gene:

Q9H1N7-S35B3_HUMAN
Tissue specificity: Preferentially and highly expressed in colon.

Evidence on tissue expression from TISSUES for SLC35B3 Gene

  • Intestine(4.3)
  • Kidney(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with SLC35B3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35B3 Gene

Orthologs for SLC35B3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B3 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia SLC35B3 35
  • 95 (a)
OneToOne
LOC607290 34
  • 92.65 (n)
cow
(Bos Taurus)
Mammalia SLC35B3 34 35
  • 90.89 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC35B3 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35B3 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b3 34 16 35
  • 84.68 (n)
rat
(Rattus norvegicus)
Mammalia Slc35b3 34
  • 84 (n)
chicken
(Gallus gallus)
Aves SLC35B3 34 35
  • 81.93 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35B3 35
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35b3 34
  • 75.79 (n)
Str.3298 34
African clawed frog
(Xenopus laevis)
Amphibia ernst 34
zebrafish
(Danio rerio)
Actinopterygii slc35b3 34 35
  • 72.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta Papst2 34 35
  • 56.36 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta S35B3_ANOGA 34
  • 55.69 (n)
worm
(Caenorhabditis elegans)
Secernentea pst-2 34 35
  • 56.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 35
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12600 34
  • 49.33 (n)
rice
(Oryza sativa)
Liliopsida Os03g0118200 34
  • 48.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 51 (a)
OneToOne
Species where no ortholog for SLC35B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B3 Gene

ENSEMBL:
Gene Tree for SLC35B3 (if available)
TreeFam:
Gene Tree for SLC35B3 (if available)

Paralogs for SLC35B3 Gene

Paralogs for SLC35B3 Gene

genes like me logo Genes that share paralogs with SLC35B3: view

Variants for SLC35B3 Gene

Sequence variations from dbSNP and Humsavar for SLC35B3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000026439 -- 8,424,242(+) CTTCC(A/T)TAGAA intron-variant
rs1000094122 -- 8,416,545(+) TGAAA(A/G)TTTCA intron-variant
rs1000179985 -- 8,436,440(+) TTTAA(A/G)ATTTT intron-variant, upstream-variant-2KB
rs1000280391 -- 8,436,095(+) TCATC(C/G/T)TGTAG nc-transcript-variant, upstream-variant-2KB
rs1000373944 -- 8,430,328(+) CAATC(G/T)TTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B3 Gene

Variant ID Type Subtype PubMed ID
esv2656617 CNV deletion 23128226
esv2731548 CNV deletion 23290073
esv3608031 CNV loss 21293372
nsv1128218 CNV deletion 24896259
nsv1133014 OTHER inversion 24896259
nsv1151332 OTHER inversion 26484159
nsv600927 CNV gain 21841781
nsv823418 CNV loss 20364138
nsv830584 CNV loss 17160897

Variation tolerance for SLC35B3 Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.12; 38.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B3 Gene

Disorders for SLC35B3 Gene

Relevant External Links for SLC35B3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B3

No disorders were found for SLC35B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B3 Gene

Publications for SLC35B3 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  2. Molecular cloning and characterization of a novel 3'-phosphoadenosine 5'-phosphosulfate transporter, PAPST2. (PMID: 16492677) Kamiyama S. … Nishihara S. (J. Biol. Chem. 2006) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64

Products for SLC35B3 Gene

Sources for SLC35B3 Gene

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