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SLC35B2 Gene

protein-coding   GIFtS: 58
GCID: GC06M044221

Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate...

(Previous names: solute carrier family 35, member B2)
  See SLC35B2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35 (Adenosine 3'-Phospho 5'-Phosphosulfate
Transporter), Member B21 2
     SLL2 5
PAPST12 3 5     3'-Phosphoadenosine 5'-Phosphosulfate Transporter2
Solute Carrier Family 35, Member B21 2     UGTrel42
Putative MAPK-Activating Protein PM152 3     Adenosine 3'-Phospho 5'-Phosphosulfate Transporter 12
Putative NF-Kappa-B-Activating Protein 482 3     Solute Carrier Family 35 Member B2 Variant 22
PAPS Transporter 12 3     Solute Carrier Family 35 Member B23

External Ids:    HGNC: 168721   Entrez Gene: 3477342   Ensembl: ENSG000001575937   OMIM: 6107885   UniProtKB: Q8TB613   

Export aliases for SLC35B2 gene to outside databases

Previous GC identifers: GC06M044225 GC06M044270 GC06M044271 GC06M044329 GC06M043943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC35B2 Gene:
Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine
5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and
glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and
transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 (PubMed
12716889)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC35B2 Gene:
SLC35B2 (solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2) is a protein-coding gene. Diseases associated with SLC35B2 include pulmonary valve stenosis, and dextrocardia. GO annotations related to this gene include 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity and signal transducer activity. An important paralog of this gene is SLC35B3.

UniProtKB/Swiss-Prot: S35B2_HUMAN, Q8TB61
Function: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS
is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in
activation of the NF-kappa-B and MAPK pathways

Gene Wiki entry for SLC35B2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_007592.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC35B2 gene promoter:
         ISGF-3   Elk-1   GATA-3   p300   Egr-4   MZF-1   Egr-2   RORalpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35B2 promoter sequence
   Search Chromatin IP Primers for SLC35B2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35B2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p12.1-p11.2   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p12.1-p11.21

SLC35B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35B2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M044221:  view genomic region     (about GC identifiers)

Start:
44,221,833 bp from pter      End:
44,225,291 bp from pter
Size:
3,459 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S35B2_HUMAN, Q8TB61 (See protein sequence)
Recommended Name: Adenosine 3'-phospho 5'-phosphosulfate transporter 1  
Size: 432 amino acids; 47515 Da
Sequence caution: Sequence=CAI20100.2; Type=Erroneous gene model prediction;
Secondary accessions: Q2VY06 Q53GA3 Q5T9W1 Q5T9W2 Q7Z2G3 Q8NBK6 Q96AR6
Alternative splicing: 3 isoforms:  Q8TB61-1   Q8TB61-2   Q8TB61-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35B2: NX_Q8TB61

Explore proteomics data for SLC35B2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC35B2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_001273438.1  NP_001273439.1  NP_001273440.1  NP_001273441.1  NP_001273442.1  NP_001273446.1  NP_001273448.1  NP_001273449.1  
    NP_835361.1  

    ENSEMBL proteins: 
     ENSP00000377399   ENSP00000377401   ENSP00000443845   ENSP00000440340  
    Reactome Protein details: Q8TB61

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAPS transporter 1
    SLC35 family of nucleotide sugar transporters

    1 InterPro protein domain:
     IPR013657 UAA

    Graphical View of Domain Structure for InterPro Entry Q8TB61

    ProtoNet protein and cluster: Q8TB61

    1 Blocks protein domain: IPB013657 UAA transporter

    UniProtKB/Swiss-Prot: S35B2_HUMAN, Q8TB61
    Similarity: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily


    Find genes that share domains with SLC35B2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35B2_HUMAN, Q8TB61
    Function: Mediates the transport of adenosine 3'-phospho 5'-phosphosulfate (PAPS), from cytosol into Golgi. PAPS
    is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in
    activation of the NF-kappa-B and MAPK pathways
    Biophysicochemical properties: Kinetic parameters: KM=0.8 uM for PAPS;

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity IMP12761501
    GO:00469643'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA12716889
         
    Find genes that share ontologies with SLC35B2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC35B2:
     Decreased Salmonella enterica   Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S35B2_HUMAN, Q8TB61: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane3
    cytosol1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus IDA12716889
    GO:0016020membrane IDA12716889
    GO:0016021integral component of membrane NAS12716889

    Find genes that share ontologies with SLC35B2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC35B2 About   (see all 6)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Biological oxidations
    Biological oxidations0.56
    Cytosolic sulfonation of small molecules0.00
    Phase II conjugation0.56
    Transport and synthesis of PAPS0.00
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    4Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of nucleotide sugars0.00
    5Metabolism
    Metabolism0.38


    Find genes that share SuperPaths with SLC35B2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2 Reactome Pathways for SLC35B2
        Transport and synthesis of PAPS
    Transport of nucleotide sugars


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35B2
    Interactions:

        Search GeneGlobe Interaction Network for SLC35B2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC35B2 (Q8TB613 ENSP000003774014) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCTS1Q9ULC43, ENSP000003603654I2D: score=1 STRING: ENSP00000360365
    GPC5ENSP000003662674STRING: ENSP00000366267
    DHHENSP000002669914STRING: ENSP00000266991
    IHHENSP000002957314STRING: ENSP00000295731
    SHHENSP000002972614STRING: ENSP00000297261
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006805xenobiotic metabolic process TAS--
    GO:0007165signal transduction IMP12761501
    GO:0030203glycosaminoglycan metabolic process TAS--
    GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling IMP12761501

    Find genes that share ontologies with SLC35B2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for SLC35B2 (S35B2)

    3 HMDB Compounds for SLC35B2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine phosphosulfateAdenosine Phosphosulfate (see all 13)485-84-7--
    Phosphoadenosine phosphosulfate3'-Phospho-5'-adenylyl sulfate (see all 9)482-67-7--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC35B2 gene (9 alternative transcripts): 
    NM_001286509.1  NM_001286510.1  NM_001286511.1  NM_001286512.1  NM_001286513.1  NM_001286517.1  NM_001286519.1  NM_001286520.1  
    NM_178148.3  

    Unigene Cluster for SLC35B2:

    Solute carrier family 35, member B2
    Hs.182885  [show with all ESTs]
    Unigene Representative Sequence: NM_178148
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495706(uc011dvu.2) ENST00000393810(uc011dvt.2) ENST00000393812(uc003oxd.3)
    ENST00000538577 ENST00000537814
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    Additional mRNA sequence: 

    AB097021.1 AB097039.1 AB106538.1 AK075456.1 AK123749.1 AK223028.1 AK293251.1 AK293344.1 
    AK307572.1 AY491520.1 BC016839.1 BC024288.1 

    17 DOTS entries:

    DT.99978753  DT.102840622  DT.100656126  DT.92470992  DT.95154225  DT.100656127  DT.100864004  DT.100728968 
    DT.316581  DT.101984824  DT.121336352  DT.121336410  DT.100852950  DT.95119151  DT.100030697  DT.121336113 
    DT.121336355 

    Selected AceView cDNA sequences (see all 521):

    BE891334 BE514895 N67775 BC024288 BQ678613 BU502640 AI073831 CR625145 
    AB097039 BG261068 BU733561 N91286 BQ054479 CR592165 AA953975 BF439971 
    BE384483 BM711990 Z38599 BM798639 BQ416606 Z42389 CA443693 AL527841 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c · 4d · 4e
    SP1:                    -                                                         
    SP2:                    -                                                         
    SP3:                    -           -     -                                       
    SP4:                    -                 -     -                                 
    SP5:                                                                              


    ECgene alternative splicing isoforms for SLC35B2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC35B2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCCTGTTGC
    SLC35B2 Expression
    About this image

    SLC35B2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC35B2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.182885

    UniProtKB/Swiss-Prot: S35B2_HUMAN, Q8TB61
    Tissue specificity: Highly expressed in the placenta, pancreas, mammary gland and skeletal muscle. Weakly or not
    expressed in colon, heart and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC35B2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35b21 , 5 solute carrier family 35, member B21, 5 88.13(n)1
    93.19(a)1
      17 (22.59 cM)5
    738361  NM_028662.21  NP_082938.11 
     455641525 
    chicken
    (Gallus gallus)
    Aves SLC35B21 solute carrier family 35, member B2 72.5(n)
    74.94(a)
      428575  XM_426131.4  XP_426131.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35B26
    solute carrier family 35 (adenosine 3'-phospho 5'-...
    71(a)
    1 ↔ 1
    1(227937103-227963633)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc35b1-prov2 solute carrier family 35, member B1 77.95(n)    BC044702.1 
    zebrafish
    (Danio rerio)
    Actinopterygii 570534712   -- 73.82(n)    57053471 
    fruit fly
    (Drosophila melanogaster)
    Insecta sll1 slalom 55.7(n)
    50.91(a)
      42115  NM_079665.4  NP_524389.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pst-11 pst-1 48.13(n)
    42.86(a)
      178980  NM_171463.4  NP_741545.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HUT16
    Protein with a role in UDP-galactose transport to ...
    23(a)
    1 → many
    XVI(87014-88033) YPL244C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G597401 AT5G59740 47.56(n)
    39(a)
      836095  NM_125366.4  NP_200782.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01157001 Os05g0115700 47.51(n)
    38.64(a)
      4337618  NM_001061001.1  NP_001054466.1 


    ENSEMBL Gene Tree for SLC35B2 (if available)
    TreeFam Gene Tree for SLC35B2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC35B2 gene
    SLC35B32  SLC35B12  
    1 SIMAP similar gene for SLC35B2 using alignment to 3 protein entries:     S35B2_HUMAN (see all proteins):
    SLC35B1

    Find genes that share paralogs with SLC35B2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC35B2 (see all 34)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2008072431,2
    C--44224113(+) TCAGGA/GCCTGC 2 A V mis10--------
    rs2009317101,2
    --44224153(+) TCGGGA/GCGCCA 2 P S mis10--------
    rs2004585561,2
    --44224203(+) CACAAA/GCTTTC 2 A V mis10--------
    rs1887317811,2
    C--44224259(+) CAAGCC/TCCAAA 1 -- int10--------
    rs1510275601,2
    --44224722(+) CCCTCC/TGCTGC 1 -- int10--------
    rs360926471,2
    C--44224749(+) AGAGC-/CTCTCTC 1 -- int10--------
    rs724547871,2
    C--44224750(+) GAGCC-/CTTCTCT 1 -- int10--------
    rs1918325171,2
    --44224821(+) CCCGGC/GGGCGG 1 -- int10--------
    rs5750341,2
    C,F,A,H--44224924(+) CTCCAC/AGATCC 1 -- int17Minor allele frequency- A:0.45MN NA WA CSA EA 548
    rs1404133891,2
    --44224931(+) ATCCGC/GGACGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC35B2 (44221833 - 44225291 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for SLC35B2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5282CNV Insertion18451855
    dgv6844n71CNV Loss21882294
    nsv462936CNV Loss19166990
    nsv524398CNV Loss19592680
    dgv6843n71CNV Loss21882294
    nsv885851CNV Loss21882294
    nsv885857CNV Loss21882294
    nsv885852CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35B2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35B2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610788    OMIM disorders: --

    2 diseases for SLC35B2:    
    About MalaCards
    pulmonary valve stenosis    dextrocardia

    5 diseases from the University of Copenhagen DISEASES database for SLC35B2:
    Chronic lymphocytic leukemia     Lymphoma     Pulmonary valve stenosis     Dextrocardia
    Ventricular septal defect

    Find genes that share disorders with SLC35B2           About GenesLikeMe

    Genetic Association Database (GAD): SLC35B2
    Human Genome Epidemiology (HuGE) Navigator: SLC35B2 (1 document)

    Export disorders for SLC35B2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC35B2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SLC35B2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Molecular cloning and identification of 3'-phosphoadenosine 5'- phosphosulfate transporter. (PubMed id 12716889)1, 2 Kamiyama S.... Nishihara S. (J. Biol. Chem. 2003)
    5. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (Oncogene 2003)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    7. Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach. (PubMed id 23464991)1 Scifo E....Lalowski M. (J. Proteome Res. 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Expression and the role of 3'-phosphoadenosine 5'-phosphosulfate transporters in human colorectal carcinoma. (PubMed id 20978009)1 Kamiyama S....Nishihara S. (Glycobiology 2011)
    10. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 347734 HGNC: 16872 AceView: NFKBIEandSLC35B2 Ensembl:ENSG00000157593 euGenes: HUgn347734
    ECgene: SLC35B2 H-InvDB: SLC35B2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC35B2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=SLC35B2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC35B2 gene:
    Search GeneIP for patents involving SLC35B2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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