Aliases for SLC35B2 Gene
External Ids for SLC35B2 Gene
Previous GeneCards Identifiers for SLC35B2 Gene
Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]
GeneCards Summary for SLC35B2 Gene
SLC35B2 (Solute Carrier Family 35 Member B2) is a Protein Coding gene. Diseases associated with SLC35B2 include Chromosome 13Q14 Deletion Syndrome and Cll/Sll. Among its related pathways are Glycosaminoglycan metabolism and Phase II conjugation. GO annotations related to this gene include signal transducer activity and 3-phosphoadenosine 5-phosphosulfate transmembrane transporter activity. An important paralog of this gene is SLC35B1.
UniProtKB/Swiss-Prot for SLC35B2 Gene
Mediates the transport of adenosine 3-phospho 5-phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF-kappa-B and MAPK pathways.