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Aliases for SLC35B1 Gene

Aliases for SLC35B1 Gene

  • Solute Carrier Family 35, Member B1 2 3
  • UGTREL1 3 4 6
  • UDP-Galactose Transporter-Related Protein 1 3 4
  • HUGTrel1 3 4
  • Solute Carrier Family 35 Member B1 3
  • UDP-Galactose Transporter Related 3

External Ids for SLC35B1 Gene

Previous GeneCards Identifiers for SLC35B1 Gene

  • GC17M048120
  • GC17M048253
  • GC17M045133
  • GC17M047779
  • GC17M043143

Summaries for SLC35B1 Gene

Entrez Gene Summary for SLC35B1 Gene

  • This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35B1 Gene

SLC35B1 (Solute Carrier Family 35, Member B1) is a Protein Coding gene. GO annotations related to this gene include UDP-galactose transmembrane transporter activity. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot for SLC35B1 Gene

  • Probable sugar transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B1 Gene

Genomics for SLC35B1 Gene

Regulatory Elements for SLC35B1 Gene

Genomic Location for SLC35B1 Gene

49,700,934 bp from pter
49,709,014 bp from pter
8,081 bases
Minus strand

Genomic View for SLC35B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC35B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B1 Gene

Proteins for SLC35B1 Gene

  • Protein details for SLC35B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member B1
    Protein Accession:
    Secondary Accessions:
    • B4DEC4
    • J3KQV4
    • Q96EW7

    Protein attributes for SLC35B1 Gene

    322 amino acids
    Molecular mass:
    35760 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35B1 Gene


neXtProt entry for SLC35B1 Gene

Proteomics data for SLC35B1 Gene at MOPED

Post-translational modifications for SLC35B1 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for SLC35B1 Gene

Domains for SLC35B1 Gene

Gene Families for SLC35B1 Gene

Protein Domains for SLC35B1 Gene

Graphical View of Domain Structure for InterPro Entry



  • P78383
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B1: view

Function for SLC35B1 Gene

Molecular function for SLC35B1 Gene

UniProtKB/Swiss-Prot Function:
Probable sugar transporter.

Gene Ontology (GO) - Molecular Function for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005459 UDP-galactose transmembrane transporter activity TAS 9010752
genes like me logo Genes that share ontologies with SLC35B1: view

Phenotypes for SLC35B1 Gene

GenomeRNAi human phenotypes for SLC35B1:
genes like me logo Genes that share phenotypes with SLC35B1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35B1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC35B1 Gene

Localization for SLC35B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC35B1 Gene COMPARTMENTS Subcellular localization image for SLC35B1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle TAS 9010752
genes like me logo Genes that share ontologies with SLC35B1: view

Pathways for SLC35B1 Gene

SuperPathways for SLC35B1 Gene

No Data Available

Interacting Proteins for SLC35B1 Gene

Selected Interacting proteins: P78383-S35B1_HUMAN for SLC35B1 Gene via I2D

Gene Ontology (GO) - Biological Process for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9010752
GO:0055085 transmembrane transport --
GO:0072334 UDP-galactose transmembrane transport TAS 9010752
genes like me logo Genes that share ontologies with SLC35B1: view

No data available for Pathways by source for SLC35B1 Gene

Transcripts for SLC35B1 Gene

Unigene Clusters for SLC35B1 Gene

Solute carrier family 35, member B1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC35B1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP9: - - -
SP10: -

Relevant External Links for SLC35B1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35B1 Gene

mRNA expression in normal human tissues for SLC35B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for SLC35B1 Gene

This gene is overexpressed in Liver, secretome (37.4), Liver (10.5), Islet of Langerhans (10.3), and Placenta (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC35B1 Gene

SOURCE GeneReport for Unigene cluster for SLC35B1 Gene Hs.154073

genes like me logo Genes that share expressions with SLC35B1: view

Expression partners for SLC35B1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35B1 Gene

Orthologs for SLC35B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC35B1 35
  • 93.33 (n)
  • 96.62 (a)
SLC35B1 36
  • 88 (a)
(Canis familiaris)
Mammalia SLC35B1 35
  • 93.5 (n)
  • 96.38 (a)
SLC35B1 36
  • 88 (a)
(Mus musculus)
Mammalia Slc35b1 35
  • 89.75 (n)
  • 95.65 (a)
Slc35b1 16
Slc35b1 36
  • 93 (a)
(Pan troglodytes)
Mammalia SLC35B1 35
  • 99.91 (n)
  • 100 (a)
SLC35B1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc35b1 35
  • 90.17 (n)
  • 95.96 (a)
(Monodelphis domestica)
Mammalia SLC35B1 36
  • 44 (a)
(Gallus gallus)
Aves SLC35B1 35
  • 77.67 (n)
  • 88.16 (a)
SLC35B1 36
  • 86 (a)
(Anolis carolinensis)
Reptilia SLC35B1 36
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ernst1 35
slc35b1 35
  • 74.03 (n)
  • 80.98 (a)
(Danio rerio)
Actinopterygii slc35b1 35
  • 68.81 (n)
  • 71.87 (a)
slc35b1 36
  • 72 (a)
slc35b1 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001447 35
  • 56.57 (n)
  • 52.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5802 35
  • 54.48 (n)
  • 51.46 (a)
CG5802 36
  • 46 (a)
(Caenorhabditis elegans)
Secernentea hut-1 35
  • 50.78 (n)
  • 47.67 (a)
hut-1 36
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL154C 35
  • 42.94 (n)
  • 31.46 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12848g 35
  • 41.47 (n)
  • 29.83 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 35
  • 42.38 (n)
  • 30.13 (a)
HUT1 36
  • 24 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UTR3 35
  • 48.18 (n)
  • 37.62 (a)
(Oryza sativa)
Liliopsida Os06g0593100 35
  • 48.12 (n)
  • 37.09 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7081 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10721 35
  • 46.79 (n)
  • 37.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hut1 35
  • 46.97 (n)
  • 37.41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9903 36
  • 55 (a)
Species with no ortholog for SLC35B1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B1 Gene

Gene Tree for SLC35B1 (if available)
Gene Tree for SLC35B1 (if available)

Paralogs for SLC35B1 Gene

Paralogs for SLC35B1 Gene

genes like me logo Genes that share paralogs with SLC35B1: view

Variants for SLC35B1 Gene

Sequence variations from dbSNP and Humsavar for SLC35B1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8186 -- 49,701,431(-) ATCAA(A/G)AATAT utr-variant-3-prime
rs15166 -- 49,701,491(-) GCCAA(G/T)TTTGG reference, missense
rs1135034 - 49,706,301(-) GGATC(A/G)TACCC missense, reference
rs1803477 -- 49,701,356(-) AGTTC(C/T)AGTCT utr-variant-3-prime
rs2289600 -- 49,704,315(+) CTCCT(C/T)GGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B1 Gene

Variant ID Type Subtype PubMed ID
nsv525469 CNV Gain 19592680

Relevant External Links for SLC35B1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B1 Gene

Disorders for SLC35B1 Gene

Relevant External Links for SLC35B1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for SLC35B1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC35B1 Gene

Publications for SLC35B1 Gene

  1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PMID: 9010752) Ishida N. … Kawakita M. (J. Biochem. 1996) 2 3 4
  2. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (PMID: 19270184) Dejima K. … Nomura K. (FASEB J. 2009) 3 23
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC35B1 Gene

Sources for SLC35B1 Gene

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