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SLC35B1 Gene

protein-coding   GIFtS: 51
GCID: GC17M047779

Solute Carrier Family 35, Member B1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35, Member B11 2     Solute Carrier Family 35 Member B12
UGTREL12 3 5     UDP-Galactose Transporter Related2
hUGTrel12 3     UGTrel13
UDP-Galactose Transporter-Related Protein 12 3     

External Ids:    HGNC: 207981   Entrez Gene: 102372   Ensembl: ENSG000001210737   OMIM: 6107905   UniProtKB: P783833   

Export aliases for SLC35B1 gene to outside databases

Previous GC identifers: GC17M048120 GC17M048253 GC17M045133 GC17M043143


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC35B1 Gene:
This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters
in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative
splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2013)

GeneCards Summary for SLC35B1 Gene:
SLC35B1 (solute carrier family 35, member B1) is a protein-coding gene. GO annotations related to this gene include UDP-galactose transmembrane transporter activity. An important paralog of this gene is SLC35B3.

UniProtKB/Swiss-Prot: S35B1_HUMAN, P78383
Function: Probable sugar transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC35B1 gene promoter:
         HFH-3   Bach2   HNF-4alpha2   HNF-4alpha1   FOXI1   Nkx6-1   c-Myb   Zic3   MRF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC35B1 promoter sequence
   Search Chromatin IP Primers for SLC35B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.33   Ensembl cytogenetic band:  17q21.33   HGNC cytogenetic band: 17q21.32

SLC35B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35B1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M047779:  view genomic region     (about GC identifiers)

Start:
47,778,305 bp from pter      End:
47,786,376 bp from pter
Size:
8,072 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S35B1_HUMAN, P78383 (See protein sequence)
Recommended Name: Solute carrier family 35 member B1  
Size: 322 amino acids; 35760 Da
Secondary accessions: Q96EW7

Explore the universe of human proteins at neXtProt for SLC35B1: NX_P78383

Explore proteomics data for SLC35B1 at MOPED


See SLC35B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001265713.1  NP_005818.2  

ENSEMBL proteins: 
 ENSP00000240333   ENSP00000425179   ENSP00000423323   ENSP00000424367   ENSP00000424857  
 ENSP00000426961   ENSP00000427689   ENSP00000422104   ENSP00000426402   ENSP00000409548  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: UGTREL1
SLC35 family of nucleotide sugar transporters

1 InterPro protein domain:
 IPR013657 UAA

Graphical View of Domain Structure for InterPro Entry P78383

ProtoNet protein and cluster: P78383

2 Blocks protein domains:
IPB000620 Protein of unknown function DUF6
IPB013657 UAA transporter


UniProtKB/Swiss-Prot: S35B1_HUMAN, P78383
Domain: The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins (By
similarity)
Similarity: Belongs to the nucleotide-sugar transporter family. SLC35B subfamily


Find genes that share domains with SLC35B1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: S35B1_HUMAN, P78383
Function: Probable sugar transporter (By similarity)

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005459UDP-galactose transmembrane transporter activity TAS9010752
     
Find genes that share ontologies with SLC35B1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for SLC35B1:
 Increased cell number in G1, s 

     1 MGI phenotypic allele for Slc35b1 (no phenotypes)

Find genes that share phenotypes with SLC35B1           About GenesLikeMe

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35B1
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miRNA
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
S35B1_HUMAN, P78383: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
endoplasmic reticulum5
plasma membrane3

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016020membrane ----
GO:0016021integral component of membrane IEA--
GO:0043231intracellular membrane-bounded organelle TAS9010752

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35B1
Interactions:

    Search GeneGlobe Interaction Network for SLC35B1

STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

Selected Interacting proteins for SLC35B1 (P783833 ENSP000002403334) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
InteractantInteraction Details
GeneCardExternal ID(s)
MED4Q9NPJ63, ENSP000002586484I2D: score=4 STRING: ENSP00000258648
ING2Q9H1603I2D: score=5 
SPTLC2O152703I2D: score=5 
SEC61A1ENSP000002432534STRING: ENSP00000243253
SEC61A2ENSP000002984284STRING: ENSP00000298428
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006810transport TAS9010752
GO:0055085transmembrane transport ----
GO:0072334UDP-galactose transmembrane transport TAS9010752

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC35B1 (S35B1)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SLC35B1 gene (2 alternative transcripts): 
NM_001278784.1  NM_005827.2  

Unigene Cluster for SLC35B1:

Solute carrier family 35, member B1
Hs.154073  [show with all ESTs]
Unigene Representative Sequence: AK124975
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
ENST00000240333 ENST00000504260 ENST00000502406(uc002ipj.1) ENST00000508749
ENST00000507477 ENST00000507773 ENST00000503334 ENST00000508520 ENST00000502268
ENST00000513508 ENST00000435059(uc010wly.1) ENST00000514907 ENST00000515850
ENST00000511763 ENST00000508926 ENST00000511657 ENST00000509781 ENST00000505765

miRNA
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat SLC35B1
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GenScript: all cDNA clones in your preferred vector: SLC35B1 (NM_005827)
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SLC35B1

Additional mRNA sequence: 

AK098056.1 AK124975.1 AK293563.1 AK296073.1 BC011888.2 BX641166.1 D87989.1 Z36793.1 

17 DOTS entries:

DT.454326  DT.100829622  DT.100692132  DT.102830995  DT.92438015  DT.92438012  DT.97814900  DT.100788102 
DT.86854544  DT.92438022  DT.440644  DT.92438011  DT.92438019  DT.100788098  DT.40108910  DT.92438018 
DT.97859963 

Selected AceView cDNA sequences (see all 285):

CB148556 CD106778 AA195008 BM692109 CR626561 BU176739 BE777893 BQ027137 
BF197224 AW299849 BM562562 CR600895 AI089832 CA843048 BE617988 CR595746 
AI479939 CR625983 AI886208 AA862423 BM831488 CF126403 BU632912 BC011888 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B1 (see all 12)    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1:                                      -                       -     -           -                       -     -                       -         
SP2:              -     -     -     -                 -           -     -           -                       -     -                                 
SP3:                                      -           -           -     -           -                       -     -                                 
SP4:              -     -     -     -                             -     -                                                                           
SP5:                                      -     -     -           -     -           -                                                               


ECgene alternative splicing isoforms for SLC35B1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC35B1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CAGTGGGTGG
SLC35B1 Expression
About this image


SLC35B1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Bone (Muscoskeletal System)
         Rib
 
 Thyroid (Endocrine System)
SLC35B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC35B1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.154073
    Custom PCR Arrays for SLC35B1
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35B1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B1 gene from Selected species (see all 24)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc35b11 , 5 solute carrier family 35, member B11, 5 89.75(n)1
95.65(a)1
  11 (59.01 cM)5
1101721  NM_016752.11  NP_058032.11 
 953846925 
chicken
(Gallus gallus)
Aves SLC35B11 solute carrier family 35, member B1 77.67(n)
88.16(a)
  395185  NM_204514.1  NP_989845.1 
lizard
(Anolis carolinensis)
Reptilia SLC35B16
solute carrier family 35, member B1
81(a)
1 ↔ 1
6(76772751-76793125)
African clawed frog
(Xenopus laevis)
Amphibia AJ506039.12   -- 77.11(n)    AJ506039.1 
zebrafish
(Danio rerio)
Actinopterygii slc35b11 solute carrier family 35, member B1 68.81(n)
71.87(a)
  447844  NM_001004583.1  NP_001004583.1 
fruit fly
(Drosophila melanogaster)
Insecta CG58021 CG5802 54.48(n)
51.46(a)
  42510  NM_142692.3  NP_650949.1 
worm
(Caenorhabditis elegans)
Secernentea hut-11 hut-1 50.78(n)
47.67(a)
  176690  NM_067251.3  NP_499652.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT11 HUT1 42.38(n)
30.13(a)
  855832   NP_015080.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons UTR31 UTR3 48.18(n)
37.62(a)
  837998  NM_101303.3  NP_563949.1 
rice
(Oryza sativa)
Liliopsida Os06g05931001 Os06g0593100 48.12(n)
37.09(a)
  4341421  NM_001064510.1  NP_001057975.1 


ENSEMBL Gene Tree for SLC35B1 (if available)
TreeFam Gene Tree for SLC35B1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC35B1 gene
SLC35B32  SLC35B22  
2 SIMAP similar genes for SLC35B1 using alignment to 11 protein entries:     S35B1_HUMAN (see all proteins):
DKFZp686B17238    SLC35B2

Find genes that share paralogs with SLC35B1           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC35B1 (see all 225)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1445946871,2
--47778461(+) GCACAA/GTTCTG 1 -- ds50010--------
rs1867139401,2
--47778468(+) TCTGCA/GATCTC 1 -- ds50010--------
rs1911284061,2
--47778515(+) GAATCG/TCCCAC 1 -- ds50010--------
rs1832480591,2
--47778541(+) ACACCC/TGTGAG 1 -- ds50010--------
rs1435744681,2
C--47778636(+) AAAAA-/AA    
   AAAAC
CCACC
1 -- ds50010--------
rs1461687651,2
C--47778680(+) AGAAT-/ATGTGA 1 -- ds50010--------
rs1484634321,2
C--47778700(+) ATTTTA/GTTTTA 1 -- ut310--------
rs81861,2
C,F,H--47778793(-) ATCAAG/AAATAT 1 -- ut3115Minor allele frequency- A:0.06MN NS EA NA CSA WA EU 2426
rs1124378891,2
C--47778803(+) TGTGGA/G/TGGTAG 2 -- ut311CSA 1
rs151661,2
C--47778853(-) GCCAAG/TTTTGG 2 K N mis10--------

HapMap Linkage Disequilibrium report for SLC35B1 (47778305 - 47786376 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for SLC35B1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv525469CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC35B1
DNA2.0 Custom Variant and Variant Library Synthesis for SLC35B1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 610790    OMIM disorders: --


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Genetic Association Database (GAD): SLC35B1
Human Genome Epidemiology (HuGE) Navigator: SLC35B1 (1 document)

Export disorders for SLC35B1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC35B1 gene, integrated from 10 sources (see all 15):
(articles sorted by number of sources associating them with SLC35B1)
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  1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PubMed id 9010752)1, 2, 3 Ishida N.... Kawakita M. (J. Biochem. 1996)
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (PubMed id 19270184)1, 9 Dejima K....Nomura K. (FASEB J. 2009)
  5. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. (PubMed id 23506892)1 Song Z. (Mol. Aspects Med. 2013)
  6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
  7. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
  8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
  9. Pan-genome isolation of low abundance transcripts using SAGE tag. (PubMed id 17113583)1 Kim Y.C....Wang S.M. (FEBS Lett. 2006)
  10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10237 HGNC: 20798 AceView: SLC35B1 Ensembl:ENSG00000121073 euGenes: HUgn10237
ECgene: SLC35B1 H-InvDB: SLC35B1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC35B1 Pharmacogenomics, SNPs, Pathways
GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=SLC35B1

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC35B1 gene:
Search GeneIP for patents involving SLC35B1

GeneCards and IP:
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