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Aliases for SLC35B1 Gene

Aliases for SLC35B1 Gene

  • Solute Carrier Family 35 Member B1 2 3 5
  • UDP-Galactose Transporter-Related Protein 1 3 4
  • Solute Carrier Family 35, Member B1 2 3
  • HUGTrel1 3 4
  • UGTREL1 3 4
  • UDP-Galactose Transporter Related 3

External Ids for SLC35B1 Gene

Previous GeneCards Identifiers for SLC35B1 Gene

  • GC17M048120
  • GC17M048253
  • GC17M045133
  • GC17M047779
  • GC17M043143

Summaries for SLC35B1 Gene

Entrez Gene Summary for SLC35B1 Gene

  • This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC35B1 Gene

SLC35B1 (Solute Carrier Family 35 Member B1) is a Protein Coding gene. GO annotations related to this gene include UDP-galactose transmembrane transporter activity. An important paralog of this gene is SLC35B2.

UniProtKB/Swiss-Prot for SLC35B1 Gene

  • Probable sugar transporter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35B1 Gene

Genomics for SLC35B1 Gene

Regulatory Elements for SLC35B1 Gene

Promoters for SLC35B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35B1 Gene

Chromosome:
17
Start:
49,700,934 bp from pter
End:
49,709,014 bp from pter
Size:
8,081 bases
Orientation:
Minus strand

Genomic View for SLC35B1 Gene

Genes around SLC35B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35B1 Gene

Proteins for SLC35B1 Gene

  • Protein details for SLC35B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78383-S35B1_HUMAN
    Recommended name:
    Solute carrier family 35 member B1
    Protein Accession:
    P78383
    Secondary Accessions:
    • B4DEC4
    • J3KQV4
    • Q96EW7

    Protein attributes for SLC35B1 Gene

    Size:
    322 amino acids
    Molecular mass:
    35760 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35B1 Gene

Proteomics data for SLC35B1 Gene at MOPED

Post-translational modifications for SLC35B1 Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for SLC35B1 Gene

Domains & Families for SLC35B1 Gene

Gene Families for SLC35B1 Gene

Protein Domains for SLC35B1 Gene

Graphical View of Domain Structure for InterPro Entry

P78383

UniProtKB/Swiss-Prot:

S35B1_HUMAN :
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
Domain:
  • The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.
genes like me logo Genes that share domains with SLC35B1: view

Function for SLC35B1 Gene

Molecular function for SLC35B1 Gene

UniProtKB/Swiss-Prot Function:
Probable sugar transporter.
genes like me logo Genes that share phenotypes with SLC35B1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35B1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35B1 Gene

Localization for SLC35B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35B1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35B1 Gene COMPARTMENTS Subcellular localization image for SLC35B1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030173 integral component of Golgi membrane IBA --
GO:0043231 intracellular membrane-bounded organelle TAS 9010752
genes like me logo Genes that share ontologies with SLC35B1: view

Pathways & Interactions for SLC35B1 Gene

SuperPathways for SLC35B1 Gene

No Data Available

Interacting Proteins for SLC35B1 Gene

Selected Interacting proteins: P78383-S35B1_HUMAN for SLC35B1 Gene via I2D

Gene Ontology (GO) - Biological Process for SLC35B1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35B1 Gene

Drugs & Compounds for SLC35B1 Gene

No Compound Related Data Available

Transcripts for SLC35B1 Gene

Unigene Clusters for SLC35B1 Gene

Solute carrier family 35, member B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35B1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: -
SP11:
SP12:

Relevant External Links for SLC35B1 Gene

GeneLoc Exon Structure for
SLC35B1
ECgene alternative splicing isoforms for
SLC35B1

Expression for SLC35B1 Gene

mRNA expression in normal human tissues for SLC35B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35B1 Gene

This gene is overexpressed in Liver, secretome (37.4), Liver (10.5), Islet of Langerhans (10.3), and Placenta (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for SLC35B1 Gene



SOURCE GeneReport for Unigene cluster for SLC35B1 Gene Hs.154073

genes like me logo Genes that share expression patterns with SLC35B1: view

Protein tissue co-expression partners for SLC35B1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35B1 Gene

Orthologs for SLC35B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35B1 36
  • 100 (a)
OneToOne
SLC35B1 35
  • 99.91 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia SLC35B1 36
  • 88 (a)
OneToOne
SLC35B1 35
  • 93.33 (n)
  • 96.62 (a)
dog
(Canis familiaris)
Mammalia SLC35B1 35
  • 93.5 (n)
  • 96.38 (a)
SLC35B1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35b1 16
Slc35b1 35
  • 89.75 (n)
  • 95.65 (a)
Slc35b1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC35B1 36
  • 44 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35b1 35
  • 90.17 (n)
  • 95.96 (a)
chicken
(Gallus gallus)
Aves SLC35B1 35
  • 77.67 (n)
  • 88.16 (a)
SLC35B1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35B1 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ernst1 35
slc35b1 35
  • 74.03 (n)
  • 80.98 (a)
zebrafish
(Danio rerio)
Actinopterygii slc35b1 35
  • 68.81 (n)
  • 71.87 (a)
slc35b1 36
  • 72 (a)
OneToMany
slc35b1 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001447 35
  • 56.57 (n)
  • 52.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5802 35
  • 54.48 (n)
  • 51.46 (a)
CG5802 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hut-1 36
  • 41 (a)
OneToOne
hut-1 35
  • 50.78 (n)
  • 47.67 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL154C 35
  • 42.94 (n)
  • 31.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HUT1 35
  • 42.38 (n)
  • 30.13 (a)
HUT1 36
  • 24 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D12848g 35
  • 41.47 (n)
  • 29.83 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UTR3 35
  • 48.18 (n)
  • 37.62 (a)
rice
(Oryza sativa)
Liliopsida Os06g0593100 35
  • 48.12 (n)
  • 37.09 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU10721 35
  • 46.79 (n)
  • 37.58 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hut1 35
  • 46.97 (n)
  • 37.41 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7081 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9903 36
  • 55 (a)
OneToOne
Species with no ortholog for SLC35B1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC35B1 Gene

ENSEMBL:
Gene Tree for SLC35B1 (if available)
TreeFam:
Gene Tree for SLC35B1 (if available)

Paralogs for SLC35B1 Gene

Paralogs for SLC35B1 Gene

genes like me logo Genes that share paralogs with SLC35B1: view

Variants for SLC35B1 Gene

Sequence variations from dbSNP and Humsavar for SLC35B1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1135034 - 49,706,301(-) GGATC(A/G)TACCC reference, missense
rs8186 -- 49,701,431(-) ATCAA(A/G)AATAT utr-variant-3-prime
rs1803477 -- 49,701,356(-) AGTTC(C/T)AGTCT utr-variant-3-prime
rs2289600 -- 49,704,315(+) CTCCT(C/T)GGAAA intron-variant
rs2289601 -- 49,707,188(+) GCAGA(A/G)TTTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35B1 Gene

Variant ID Type Subtype PubMed ID
nsv525469 CNV Gain 19592680

Variation tolerance for SLC35B1 Gene

Residual Variation Intolerance Score: 58.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35B1 Gene

HapMap Linkage Disequilibrium report
SLC35B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35B1 Gene

Disorders for SLC35B1 Gene

Relevant External Links for SLC35B1

Genetic Association Database (GAD)
SLC35B1
Human Genome Epidemiology (HuGE) Navigator
SLC35B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35B1

No disorders were found for SLC35B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35B1 Gene

Publications for SLC35B1 Gene

  1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PMID: 9010752) Ishida N. … Kawakita M. (J. Biochem. 1996) 2 3 4 67
  2. The ortholog of human solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) is involved in maintenance of ER homeostasis and essential for larval development in Caenorhabditis elegans. (PMID: 19270184) Dejima K. … Nomura K. (FASEB J. 2009) 3 23
  3. Roles of the nucleotide sugar transporters (SLC35 family) in health and disease. (PMID: 23506892) Song Z. (Mol. Aspects Med. 2013) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A whole genome screen for HIV restriction factors. (PMID: 22082156) Liu L. … McKnight A. (Retrovirology 2011) 3

Products for SLC35B1 Gene

Sources for SLC35B1 Gene

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