SLC35A5 Gene
protein-coding GIFtS: 45
GCID: GC03P112281
|
|
solute carrier family 35, member A5
| |
Aliases
for SLC35A5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member A51 2 | | FLJ207301 | | Probable UDP-Sugar Transporter Protein SLC35A52 | | Solute Carrier Family 35 Member A53 |
Export aliases for SLC35A5 gene to outside databasesPrevious GC identifers: GC03P111851 GC03P113562 GC03P113601 GC03P113763 GC03P109664 |
Summaries
for SLC35A5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC35A5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC35A5 gene promoter:
Nkx3-1 v4 LHX3b/Lhx3b Tal-1beta Nkx3-1 v2 Nkx6-1 Nkx3-1 v3 LHX3a/Lhx3a ZID ITF-2 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35A5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35A5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q13.2 Ensembl cytogenetic band: 3q13.2 HGNC cytogenetic band: 3q13.13SLC35A5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P112281: view genomic region
(about GC identifiers)
Start:
|
112,280,556 bp from pter |
End:
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112,304,424 bp from pter |
Size:
|
23,869 bases |
Orientation:
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plus strand |
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Proteins
for SLC35A5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35A5_HUMAN, Q9BS91 (See
protein sequence)Recommended Name: Probable UDP-sugar transporter protein SLC35A5 Size: 424 amino acids; 48500 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAD18792.1; Type=Erroneous initiation;
Secondary accessions: D3DN66 Q69YY6 Q6ZMD6 Q9NWM9Explore the universe of human proteins at neXtProt for SLC35A5: NX_Q9BS91
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BS91
SLC35A5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060415.1
ENSEMBL proteins: ENSP00000419958 ENSP00000417654 ENSP00000418265 ENSP00000261034 ENSP00000420398
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC35A5 for ontologies About GeneDecksing
SLC35A5 Antibody Products:
Assay Products for SLC35A5: |
Protein
Domains /
Families
for SLC35A5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35A5 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9BS91ProtoNet protein and cluster: Q9BS91 1 Blocks protein family: IPB007271 Nucleotide-sugar transporter
UniProtKB/Swiss-Prot: S35A5_HUMAN, Q9BS91Similarity: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily |
Function
for SLC35A5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: SLC35A5 (NM_017945) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35A5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35A5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A5 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005338 | nucleotide-sugar transmembrane transporter activity |
IEA | -- | | GO:0005351 | sugar:hydrogen symporter activity |
IEA | -- |
SLC35A5 for ontologies About GeneDecksing
Animal Models:
1 MGI phenotypic allele  for Slc35a5 (no phenotypes)
SLC35A5 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC35A5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35A5
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for SLC35A5 (Q9BS913 ENSP000004176544) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015780 | nucleotide-sugar transport |
IEA | -- |
SLC35A5 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC35A5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35A5
Search CenterWatch for drugs/clinical trials and news about SLC35A5 / S35A5
|
Transcripts
for SLC35A5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35A5 gene: NM_017945.3 Unigene Cluster for SLC35A5: Solute carrier family 35, member A5 Hs.237480 [show with all ESTs]Unigene Representative Sequence: NM_0179457 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000484995 ENST00000492406(uc003dze.3) ENST00000468642 ENST00000261034
ENST00000460713 ENST00000494706 ENST00000460615
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC35A5 (NM_017945) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35A5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35A5 |
Additional cDNA sequence: AB075484.1 AK000737.1 AK001992.1 AK098839.1 AK172825.1 AK297411.1 AL117531.1 AY358994.1 BC005207.1 BC010307.1 BC013046.1 11 DOTS entries: DT.315607 DT.101983875 DT.92426391 DT.100787127 DT.70103401 DT.75147843 DT.99996501 DT.100026761 DT.100674008 DT.120895649 DT.120895645 24/210 AceView cDNA sequences (see all 210): BP359888 NM_017945 BU162305 AL597712 BP377892 AW137240 AU123880 BG289734 AK098839 BQ219150 BQ223874 BX470416 CA396826 BF197943 BP364276 BP335918 AA862164 BC010307 BU509096 AU137327 BU167282 CK819020 BM918368 BX092640
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A5 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | ^ | 9 |
|---|
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| SP1: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC35A5
|
Expression
for SLC35A5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35A5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGATGAATA
About this image
See SLC35A5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35A5
SOURCE GeneReport for Unigene cluster: Hs.237480
SABiosciences Custom PCR Arrays for SLC35A5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35A5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC35A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35A5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A5 |
Orthologs
for SLC35A5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35A5 gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for SLC35A5 (if available)
TreeFam Gene Tree for SLC35A5 (if available) |
Paralogs
for SLC35A5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC35A5 gene
- SLC35A12 SLC35A22 SLC35A42 SLC35A32
SLC35A5 for paralogs About GeneDecksing
|
Genomic Variants
for SLC35A5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35A5 (112280556 - 112304424 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for SLC35A5
1 CNV: 98405 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35A5 |
|
Disorders
/ Diseases
for SLC35A5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35A5 for disorders About GeneDecksing
2  diseases for SLC35A5: About MalaCardsfanconi's anemia anemia
Export disorders for SLC35A5 gene to outside databases
|
Publications
for SLC35A5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35A5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35A5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PubMed id 19850743)1 Vanderwerf S.M....Bagby G.C. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC35A5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC35A5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35A5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35A5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC35A5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC35A5 gene:
Search GeneIP for patents involving SLC35A5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35A5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for SLC35A5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC35A5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35A5 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for SLC35A5 | | OriGene 3'-UTR Clone for SLC35A5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for SLC35A5 | | OriGene Custom Protein Services for SLC35A5 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35A5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35A5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35A5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35A5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35A5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35A5 |
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| |  |  |  |  | | | | |
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 | | | SLC35A5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A5 |
|  |  |  | | | | ThermoFisher Antibodies for SLC35A5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35A5 |
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