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Aliases for SLC35A5 Gene

Aliases for SLC35A5 Gene

  • Solute Carrier Family 35 Member A5 2 3 4 5
  • Solute Carrier Family 35, Member A5 2

External Ids for SLC35A5 Gene

Previous GeneCards Identifiers for SLC35A5 Gene

  • GC03P111851
  • GC03P113562
  • GC03P113601
  • GC03P113763
  • GC03P112281
  • GC03P109664

Summaries for SLC35A5 Gene

GeneCards Summary for SLC35A5 Gene

SLC35A5 (Solute Carrier Family 35 Member A5) is a Protein Coding gene. GO annotations related to this gene include sugar:proton symporter activity and nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35A1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A5 Gene

Genomics for SLC35A5 Gene

Regulatory Elements for SLC35A5 Gene

Enhancers for SLC35A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC35A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35A5 Gene

Chromosome:
3
Start:
112,561,709 bp from pter
End:
112,585,577 bp from pter
Size:
23,869 bases
Orientation:
Plus strand

Genomic View for SLC35A5 Gene

Genes around SLC35A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A5 Gene

Proteins for SLC35A5 Gene

  • Protein details for SLC35A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS91-S35A5_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A5
    Protein Accession:
    Q9BS91
    Secondary Accessions:
    • D3DN66
    • Q69YY6
    • Q6ZMD6
    • Q9NWM9

    Protein attributes for SLC35A5 Gene

    Size:
    424 amino acids
    Molecular mass:
    48500 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAD18792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC35A5 Gene

Proteomics data for SLC35A5 Gene at MOPED

Post-translational modifications for SLC35A5 Gene

  • Glycosylation at Asn 204
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC35A5 Gene

No data available for DME Specific Peptides for SLC35A5 Gene

Domains & Families for SLC35A5 Gene

Gene Families for SLC35A5 Gene

Protein Domains for SLC35A5 Gene

Suggested Antigen Peptide Sequences for SLC35A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS91

UniProtKB/Swiss-Prot:

S35A5_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A5: view

Function for SLC35A5 Gene

Phenotypes for SLC35A5 Gene

GenomeRNAi human phenotypes for SLC35A5:
genes like me logo Genes that share phenotypes with SLC35A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A5

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A5 Gene

Localization for SLC35A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35A5 Gene COMPARTMENTS Subcellular localization image for SLC35A5 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for SLC35A5 Gene

Pathways & Interactions for SLC35A5 Gene

SuperPathways for SLC35A5 Gene

No Data Available

Interacting Proteins for SLC35A5 Gene

Gene Ontology (GO) - Biological Process for SLC35A5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35A5 Gene

Drugs & Compounds for SLC35A5 Gene

No Compound Related Data Available

Transcripts for SLC35A5 Gene

Unigene Clusters for SLC35A5 Gene

Solute carrier family 35, member A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6:

Relevant External Links for SLC35A5 Gene

GeneLoc Exon Structure for
SLC35A5
ECgene alternative splicing isoforms for
SLC35A5

Expression for SLC35A5 Gene

mRNA expression in normal human tissues for SLC35A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35A5 Gene

This gene is overexpressed in Monocytes (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35A5 Gene



SOURCE GeneReport for Unigene cluster for SLC35A5 Gene Hs.237480

genes like me logo Genes that share expression patterns with SLC35A5: view

Protein tissue co-expression partners for SLC35A5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC35A5 Gene

Orthologs for SLC35A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC35A5 35
  • 90.53 (n)
  • 89.26 (a)
SLC35A5 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC35A5 35
  • 89.47 (n)
  • 91.27 (a)
SLC35A5 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35a5 35
  • 86.49 (n)
  • 86.26 (a)
Slc35a5 16
Slc35a5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC35A5 35
  • 99.69 (n)
  • 99.53 (a)
SLC35A5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc35a5 35
  • 86.02 (n)
  • 84.6 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35A5 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC35A5 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC35A5 35
  • 70.96 (n)
  • 70.64 (a)
SLC35A5 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC35A5 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a5 35
  • 62.61 (n)
  • 59.61 (a)
zebrafish
(Danio rerio)
Actinopterygii slc35a5 35
  • 62.17 (n)
  • 57.59 (a)
zgc66231 35
slc35a5 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14040 36
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35335 35
  • 27.82 (n)
  • 13.1 (a)
rice
(Oryza sativa)
Liliopsida Os07g0573700 35
  • 47.83 (n)
  • 34.59 (a)
Species with no ortholog for SLC35A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A5 Gene

ENSEMBL:
Gene Tree for SLC35A5 (if available)
TreeFam:
Gene Tree for SLC35A5 (if available)

Paralogs for SLC35A5 Gene

Paralogs for SLC35A5 Gene

genes like me logo Genes that share paralogs with SLC35A5: view

Variants for SLC35A5 Gene

Sequence variations from dbSNP and Humsavar for SLC35A5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs17849939 - 112,580,857(+) GGCTA(A/T)TATCT reference, missense
rs728568 -- 112,573,591(+) AGTAG(C/G)CTTCA intron-variant
rs766968 -- 112,573,031(+) TGGAG(C/T)TGTTG intron-variant
rs766969 -- 112,573,000(+) ATGTA(A/G)TAGAA intron-variant
rs1877363 -- 112,584,337(+) ATTAT(A/G)GCGAT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35A5 Gene

Variant ID Type Subtype PubMed ID
nsv877342 CNV Gain 21882294
esv2491896 CNV Deletion 19546169

Variation tolerance for SLC35A5 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC35A5 Gene

Disorders for SLC35A5 Gene

Relevant External Links for SLC35A5

Genetic Association Database (GAD)
SLC35A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35A5

No disorders were found for SLC35A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A5 Gene

Publications for SLC35A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35A5 Gene

Sources for SLC35A5 Gene

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