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Aliases for SLC35A5 Gene

Aliases for SLC35A5 Gene

  • Solute Carrier Family 35 Member A5 2 3 4 5
  • Solute Carrier Family 35, Member A5 2

External Ids for SLC35A5 Gene

Previous GeneCards Identifiers for SLC35A5 Gene

  • GC03P111851
  • GC03P113562
  • GC03P113601
  • GC03P113763
  • GC03P112281
  • GC03P109664

Summaries for SLC35A5 Gene

Entrez Gene Summary for SLC35A5 Gene

  • This gene encodes a transmembrane protein which belongs to subfamily 35A of the solute carrier superfamily. The encoded protein is a nucleoside-sugar transporter. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

GeneCards Summary for SLC35A5 Gene

SLC35A5 (Solute Carrier Family 35 Member A5) is a Protein Coding gene. GO annotations related to this gene include sugar:proton symporter activity and nucleotide-sugar transmembrane transporter activity. An important paralog of this gene is SLC35A2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A5 Gene

Genomics for SLC35A5 Gene

Regulatory Elements for SLC35A5 Gene

Enhancers for SLC35A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G112539 1.2 FANTOM5 ENCODE dbSUPER 25.9 -21.4 -21392 0.9 CBX5 IKZF1 JUNB ETV6 CREM SPI1 SLC35A5 CD200 C3orf52 MIR567 ATG3 ENSG00000279349
GH03G112494 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -63.6 -63576 6.3 TBP PKNOX1 MXI1 JUN WRNIP1 ASH2L RELA YY1 ARID3A GATA2 SLC35A5 BTLA CD200 MIR567 C3orf52 LOC105374041
GH03G112559 1.1 ENCODE 19.4 -0.1 -105 4.1 HDGF PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 SLC35A5 MIR567 C3orf52 ENSG00000279349
GH03G112531 0.7 dbSUPER 25.8 -27.8 -27792 5.5 CTCF MAFG TBX21 RAD21 ZNF316 RAD51 MAFF SMC3 ZNF433 MAFK SLC35A5 CD200 CFAP44 SLC9C1 MIR567 C3orf52 ENSG00000279349
GH03G112513 0.8 dbSUPER 18 -46.3 -46276 3.7 NFIB BACH1 EBF1 RELA CBX5 ELK1 EED ETV6 RELB CREM SLC35A5 CD200 MIR567 C3orf52 SLC9C1 OR7E100P BTLA
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35A5 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SLC35A5 Gene

112,561,709 bp from pter
112,585,577 bp from pter
23,869 bases
Plus strand

Genomic View for SLC35A5 Gene

Genes around SLC35A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A5 Gene

Proteins for SLC35A5 Gene

  • Protein details for SLC35A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A5
    Protein Accession:
    Secondary Accessions:
    • D3DN66
    • Q69YY6
    • Q6ZMD6
    • Q9NWM9

    Protein attributes for SLC35A5 Gene

    424 amino acids
    Molecular mass:
    48500 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18792.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC35A5 Gene

Post-translational modifications for SLC35A5 Gene

  • Glycosylation at Asn204
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC35A5 Gene

Domains & Families for SLC35A5 Gene

Gene Families for SLC35A5 Gene

Protein Domains for SLC35A5 Gene

Suggested Antigen Peptide Sequences for SLC35A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A5: view

Function for SLC35A5 Gene

Gene Ontology (GO) - Molecular Function for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

Phenotypes for SLC35A5 Gene

GenomeRNAi human phenotypes for SLC35A5:
genes like me logo Genes that share phenotypes with SLC35A5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A5

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A5 Gene

Localization for SLC35A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A5 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A5 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

Pathways & Interactions for SLC35A5 Gene

SuperPathways for SLC35A5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC35A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015992 proton transport IEA --
genes like me logo Genes that share ontologies with SLC35A5: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35A5 Gene

Drugs & Compounds for SLC35A5 Gene

No Compound Related Data Available

Transcripts for SLC35A5 Gene

Unigene Clusters for SLC35A5 Gene

Solute carrier family 35, member A5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A5 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9
SP1: - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: - - - -

Relevant External Links for SLC35A5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC35A5 Gene

This gene is overexpressed in Monocytes (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC35A5 Gene

Protein tissue co-expression partners for SLC35A5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC35A5 Gene:


SOURCE GeneReport for Unigene cluster for SLC35A5 Gene:


Evidence on tissue expression from TISSUES for SLC35A5 Gene

  • Nervous system(4.4)
  • Kidney(4.3)
  • Liver(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with SLC35A5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A5 Gene

Orthologs for SLC35A5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC35A5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35A5 34 35
  • 99.69 (n)
(Bos Taurus)
Mammalia SLC35A5 34 35
  • 90.53 (n)
(Canis familiaris)
Mammalia SLC35A5 34 35
  • 89.47 (n)
(Mus musculus)
Mammalia Slc35a5 34 16 35
  • 86.49 (n)
(Rattus norvegicus)
Mammalia Slc35a5 34
  • 86.02 (n)
(Monodelphis domestica)
Mammalia SLC35A5 35
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SLC35A5 35
  • 64 (a)
(Gallus gallus)
Aves SLC35A5 34 35
  • 70.96 (n)
(Anolis carolinensis)
Reptilia SLC35A5 35
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a5 34
  • 62.61 (n)
(Danio rerio)
Actinopterygii slc35a5 34 35
  • 62.17 (n)
zgc66231 34
fruit fly
(Drosophila melanogaster)
Insecta CG14040 35
  • 21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35335 34
  • 27.82 (n)
(Oryza sativa)
Liliopsida Os07g0573700 34
  • 47.83 (n)
Species where no ortholog for SLC35A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A5 Gene

Gene Tree for SLC35A5 (if available)
Gene Tree for SLC35A5 (if available)

Paralogs for SLC35A5 Gene

Paralogs for SLC35A5 Gene

genes like me logo Genes that share paralogs with SLC35A5: view

Variants for SLC35A5 Gene

Sequence variations from dbSNP and Humsavar for SLC35A5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs869025247 Uncertain significance 112,570,663(+) CTATC(G/T)TCAAC reference, missense
rs1000096201 -- 112,575,513(+) TTAAA(G/T)ATTTG intron-variant
rs1000101588 -- 112,569,400(+) CATAA(G/T)TATGT intron-variant
rs1000164128 -- 112,580,079(+) GTTAT(A/G)GACAC intron-variant
rs1000365234 -- 112,570,430(+) AGGCA(A/C/T)GTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35A5 Gene

Variant ID Type Subtype PubMed ID
esv2491896 CNV deletion 19546169
nsv1151003 CNV deletion 26484159
nsv591293 CNV loss 21841781
nsv591301 CNV loss 21841781

Variation tolerance for SLC35A5 Gene

Residual Variation Intolerance Score: 62.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.60; 56.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35A5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A5 Gene

Disorders for SLC35A5 Gene

Relevant External Links for SLC35A5

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC35A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A5 Gene

Publications for SLC35A5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Structure and function of nucleotide sugar transporters: Current progress. (PMID: 25210595) Hadley B. … Tiralongo J. (Comput Struct Biotechnol J 2014) 3 64
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64

Products for SLC35A5 Gene

Sources for SLC35A5 Gene

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