SLC35A4 Gene
protein-coding GIFtS: 41
GCID: GC05P139944
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|
solute carrier family 35, member A4
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Aliases
for SLC35A4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 35, Member A41 2 | | Probable UDP-Sugar Transporter Protein SLC35A42 | | Solute Carrier Family 35 (UDP-Galactose Transporter), Member A42 | | Tumor Rejection Antigen2 | | Solute Carrier Family 35 Member A43 |
Export aliases for SLC35A4 gene to outside databasesPrevious GC identifers: GC05P140528 GC05P139927 GC05P139972 GC05P139924 GC05P135089 |
Summaries
for SLC35A4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for SLC35A4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC35A4 gene promoter:
TBP p53 NRSF form 1 TFIID NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC35A4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35A4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.3 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31.3SLC35A4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P139944: view genomic region
(about GC identifiers)
Start:
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139,944,041 bp from pter |
End:
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139,948,688 bp from pter |
Size:
|
4,648 bases |
Orientation:
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plus strand |
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Proteins
for SLC35A4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: S35A4_HUMAN, Q96G79 (See
protein sequence)Recommended Name: Probable UDP-sugar transporter protein SLC35A4 Size: 324 amino acids; 34593 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Golgi apparatus (By similarity)
Miscellaneous: Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent inevolution
Secondary accessions: A8K013Explore the universe of human proteins at neXtProt for SLC35A4: NX_Q96G79
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96G79
SLC35A4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_542401.1
ENSEMBL proteins: ENSP00000327133 ENSP00000424566
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC35A4 for ontologies About GeneDecksing
SLC35A4 Antibody Products:
Assay Products for SLC35A4: |
Protein
Domains /
Families
for SLC35A4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC35A4 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96G79ProtoNet protein and cluster: Q96G79 UniProtKB/Swiss-Prot: S35A4_HUMAN, Q96G79Similarity: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily |
Function
for SLC35A4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A4 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005351 | sugar:hydrogen symporter activity |
IEA | -- |
SLC35A4 for ontologies About GeneDecksing
|
Pathways & Interactions
for SLC35A4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC35A4
|
Drugs & Compounds
for SLC35A4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC35A4
Search CenterWatch for drugs/clinical trials and news about SLC35A4 / S35A4
|
Transcripts
for SLC35A4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC35A4 gene: NM_080670.2 Unigene Cluster for SLC35A4: Solute carrier family 35, member A4 Hs.406840 [show with all ESTs]Unigene Representative Sequence: AF4450254 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000323146(uc003lgg.1) ENST00000508770 ENST00000514199(uc003lgh.1)
ENST00000514137
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A4 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC35A4 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC35A4 (NM_080670) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC35A4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35A4 |
Additional cDNA sequence: AF445025.1 AJ420598.1 AK122601.1 AK289378.1 AK307282.1 AL833972.1 BC009906.2 16 DOTS entries: DT.101984984 DT.100810892 DT.95204941 DT.75156810 DT.92458990 DT.100810894 DT.100810882 DT.120809307 DT.97855095 DT.95374368 DT.100030141 DT.92458992 DT.120809256 DT.91799426 DT.92458996 DT.99957431 24/586 AceView cDNA sequences (see all 586): BM564319 AI421417 BQ351585 BF354951 BX401289 BC009906 BF354965 BU194181 BE718415 BQ351587 BQ446204 BE718471 BM694934 AL526798 BG396626 BU073381 BQ333714 AJ420598 BE718452 BU556604 BE718420 BQ351579 BM999635 CN480228
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
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| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for SLC35A4
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Expression
for SLC35A4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC35A4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCCCACTC
About this image
See SLC35A4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC35A4
SOURCE GeneReport for Unigene cluster: Hs.406840
SABiosciences Custom PCR Arrays for SLC35A4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC35A4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC35A4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35A4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35A4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A4 |
Orthologs
for SLC35A4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC35A4 gene from 7/16 species (see all 16) About this table
ENSEMBL Gene Tree for SLC35A4 (if available)
TreeFam Gene Tree for SLC35A4 (if available) |
Paralogs
for SLC35A4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC35A4 gene
- SLC35A12 SLC35A22 SLC35A32 SLC35A52
SLC35A4 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for SLC35A4
PGOHUM00000263129
|
Genomic Variants
for SLC35A4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC35A4 (139944041 - 139948688 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC35A4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35A4 |
|
Disorders
/ Diseases
for SLC35A4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC35A4 for disorders About GeneDecksing
1  disease for SLC35A4: About MalaCardslung cancer
Export disorders for SLC35A4 gene to outside databases
|
Publications
for SLC35A4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC35A4 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC35A4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes. (PubMed id 12782588)1 Yamada A.... Itoh K. (2003)
- The nucleotide-sugar transporter family: a phylogenetic approach. (PubMed id 12770764)2 Martinez-Duncker I.... Oriol R. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for SLC35A4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC35A4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC35A4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC35A4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC35A4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC35A4 gene:
Search GeneIP for patents involving SLC35A4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC35A4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC35A4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC35A4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC35A4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC35A4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC35A4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC35A4 |
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 | | | SLC35A4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A4 |
|  |  |  | | | | ThermoFisher Antibodies for SLC35A4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC35A4 |
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