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Aliases for SLC35A4 Gene

Aliases for SLC35A4 Gene

  • Solute Carrier Family 35 Member A4 2 3 4 5
  • Solute Carrier Family 35, Member A4 2

External Ids for SLC35A4 Gene

Previous GeneCards Identifiers for SLC35A4 Gene

  • GC05P140528
  • GC05P139927
  • GC05P139972
  • GC05P139924
  • GC05P139944
  • GC05P135089
  • GC05P140697
  • GC05P141463

Summaries for SLC35A4 Gene

GeneCards Summary for SLC35A4 Gene

SLC35A4 (Solute Carrier Family 35 Member A4) is a Protein Coding gene. GO annotations related to this gene include sugar:proton symporter activity. An important paralog of this gene is SLC35A5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A4 Gene

Genomics for SLC35A4 Gene

Regulatory Elements for SLC35A4 Gene

Promoters for SLC35A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC35A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC35A4 Gene

Chromosome:
5
Start:
140,564,456 bp from pter
End:
140,569,104 bp from pter
Size:
4,649 bases
Orientation:
Plus strand

Genomic View for SLC35A4 Gene

Genes around SLC35A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A4 Gene

Proteins for SLC35A4 Gene

  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G79-S35A4_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Protein Accession:
    Q96G79
    Secondary Accessions:
    • A8K013

    Protein attributes for SLC35A4 Gene

    Size:
    324 amino acids
    Molecular mass:
    34593 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Classified as NST family 1 subfamily D in a phylogenic study. Family 1 seems to be the most recent in evolution.

neXtProt entry for SLC35A4 Gene

Proteomics data for SLC35A4 Gene at MOPED

Post-translational modifications for SLC35A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35A4 Gene

No data available for DME Specific Peptides for SLC35A4 Gene

Domains & Families for SLC35A4 Gene

Gene Families for SLC35A4 Gene

Protein Domains for SLC35A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G79

UniProtKB/Swiss-Prot:

S35A4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A4: view

Function for SLC35A4 Gene

genes like me logo Genes that share phenotypes with SLC35A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A4

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A4 Gene

Localization for SLC35A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A4 Gene

Membrane; Multi-pass membrane protein. Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC35A4 Gene COMPARTMENTS Subcellular localization image for SLC35A4 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for SLC35A4 Gene

Pathways & Interactions for SLC35A4 Gene

SuperPathways for SLC35A4 Gene

No Data Available

Interacting Proteins for SLC35A4 Gene

Gene Ontology (GO) - Biological Process for SLC35A4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SLC35A4 Gene

Drugs & Compounds for SLC35A4 Gene

No Compound Related Data Available

Transcripts for SLC35A4 Gene

Unigene Clusters for SLC35A4 Gene

Solute carrier family 35, member A4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for SLC35A4 Gene

GeneLoc Exon Structure for
SLC35A4
ECgene alternative splicing isoforms for
SLC35A4

Expression for SLC35A4 Gene

mRNA expression in normal human tissues for SLC35A4 Gene

SOURCE GeneReport for Unigene cluster for SLC35A4 Gene Hs.406840

genes like me logo Genes that share expression patterns with SLC35A4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SLC35A4 Gene

Orthologs for SLC35A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35A4 35
  • 99.28 (n)
  • 99.69 (a)
SLC35A4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC35A4 36
  • 95 (a)
OneToOne
SLC35A4 35
  • 89.09 (n)
  • 94.75 (a)
dog
(Canis familiaris)
Mammalia SLC35A4 35
  • 89.51 (n)
  • 94.14 (a)
SLC35A4 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc35a4 16
Gm5866 36
  • 83 (a)
OneToMany
Slc35a4 36
  • 89 (a)
OneToMany
Slc35a4 35
  • 85.96 (n)
  • 88.85 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC35A4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 25 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Slc35a4 35
  • 87.1 (n)
  • 90.09 (a)
chicken
(Gallus gallus)
Aves SLC35A4 35
  • 64.29 (n)
  • 60.71 (a)
lizard
(Anolis carolinensis)
Reptilia SLC35A4 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a4 35
  • 57.28 (n)
  • 53.97 (a)
Str.15202 35
zebrafish
(Danio rerio)
Actinopterygii slc35a4 36
  • 46 (a)
OneToOne
slc35a4 35
  • 55.06 (n)
  • 49.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14040 36
  • 19 (a)
OneToMany
Species with no ortholog for SLC35A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A4 Gene

ENSEMBL:
Gene Tree for SLC35A4 (if available)
TreeFam:
Gene Tree for SLC35A4 (if available)

Paralogs for SLC35A4 Gene

Paralogs for SLC35A4 Gene

Pseudogenes.org Pseudogenes for SLC35A4 Gene

genes like me logo Genes that share paralogs with SLC35A4: view

Variants for SLC35A4 Gene

Sequence variations from dbSNP and Humsavar for SLC35A4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1043658 -- 140,568,920(+) CCACT(A/C/T)TGGGG utr-variant-3-prime
rs1043696 -- 140,569,067(+) GTCTT(C/T)TAGGC utr-variant-3-prime
rs11551312 -- 140,566,684(+) TATGC(A/G)GCTCA utr-variant-5-prime
rs11551313 -- 140,566,960(+) CCATG(G/T)GACTC utr-variant-5-prime
rs34528189 -- 140,568,734(+) ACAGT(-/A)GCTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC35A4 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV Loss 19166990

Variation tolerance for SLC35A4 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35A4 Gene

HapMap Linkage Disequilibrium report
SLC35A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A4 Gene

Disorders for SLC35A4 Gene

Relevant External Links for SLC35A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35A4

No disorders were found for SLC35A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A4 Gene

Publications for SLC35A4 Gene

  1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev D.E. … Baranov P.V. (Elife 2015) 3 67
  2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Gene and peptide analyses of newly defined lung cancer antigens recognized by HLA-A2402-restricted tumor-specific cytotoxic T lymphocytes. (PMID: 12782588) Yamada A. … Itoh K. (Cancer Res. 2003) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for SLC35A4 Gene

Sources for SLC35A4 Gene

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