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Aliases for SLC35A4 Gene

Aliases for SLC35A4 Gene

  • Solute Carrier Family 35 Member A4 2 3 4 5
  • Solute Carrier Family 35, Member A4 2

External Ids for SLC35A4 Gene

Previous GeneCards Identifiers for SLC35A4 Gene

  • GC05P140528
  • GC05P139927
  • GC05P139972
  • GC05P139924
  • GC05P139944
  • GC05P135089
  • GC05P140697
  • GC05P141463
  • GC05P141525
  • GC05P141679
  • GC05P141781
  • GC05P141851

Summaries for SLC35A4 Gene

GeneCards Summary for SLC35A4 Gene

SLC35A4 (Solute Carrier Family 35 Member A4) is a Protein Coding gene. GO annotations related to this gene include sugar:proton symporter activity. An important paralog of this gene is SLC35A2.

Additional gene information for SLC35A4 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35A4 Gene

Genomics for SLC35A4 Gene

Regulatory Elements for SLC35A4 Gene

Enhancers for SLC35A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H140710 1.2 ENCODE 19.4 +146.5 146528 1 PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 HARS2 PURA ANKHD1 HDAC3 WDR55 LOC102723915 PCDHB18P IK PCDHA4 HARS
GH05H140717 1.2 ENCODE 19.4 +154.7 154681 2 MLX ZNF416 ZNF143 SP3 PPARGC1A MEF2D GLIS1 RCOR2 NBN KDM1A ANKHD1 HARS2 PURA HDAC3 WDR55 PCDHB18P PCDHB19P TMCO6 PCDHB12 HARS
GH05H140609 1.7 FANTOM5 Ensembl ENCODE 12.8 +46.4 46445 3 PKNOX1 ATF1 FOXA2 ARNT TCF12 ZNF766 CBX5 GATA2 ATF7 NCOA1 CD14 APBB3 TMCO6 SLC35A4 IK EIF4EBP3 ANKHD1 NDUFA2 SRA1 HBEGF
GH05H140725 1.1 ENCODE 19.4 +161.5 161527 1 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 FOS DEK ANKHD1 HDAC3 WDR55 LOC102723915 PCDHA4 HARS HARS2 TMCO6 SLC35A4 FCHSD1
GH05H140601 1.4 FANTOM5 Ensembl ENCODE 12.4 +38.1 38140 2 FOXA2 MLX TAF1 MAX CEBPG ZNF384 YY1 POLR2A NFE2 THAP11 APBB3 CD14 SRA1 TMCO6 SLC35A4 IK NDUFA2 EIF4EBP3 HBEGF ANKHD1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC35A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC35A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187797 344 1601 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143

Genomic Location for SLC35A4 Gene

Chromosome:
5
Start:
140,564,456 bp from pter
End:
140,569,104 bp from pter
Size:
4,649 bases
Orientation:
Plus strand

Genomic View for SLC35A4 Gene

Genes around SLC35A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35A4 Gene

Proteins for SLC35A4 Gene

  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    L0R6Q1-S35U4_HUMAN
    Recommended name:
    SLC35A4 upstream open reading frame protein
    Protein Accession:
    L0R6Q1

    Protein attributes for SLC35A4 Gene

    Size:
    103 amino acids
    Molecular mass:
    11133 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for SLC35A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G79-S35A4_HUMAN
    Recommended name:
    Probable UDP-sugar transporter protein SLC35A4
    Protein Accession:
    Q96G79
    Secondary Accessions:
    • A8K013

    Protein attributes for SLC35A4 Gene

    Size:
    324 amino acids
    Molecular mass:
    34593 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC35A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC35A4 Gene

Post-translational modifications for SLC35A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC35A4 Gene

No data available for DME Specific Peptides for SLC35A4 Gene

Domains & Families for SLC35A4 Gene

Gene Families for SLC35A4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35A4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC35A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G79

UniProtKB/Swiss-Prot:

S35A4_HUMAN :
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
Family:
  • Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.
genes like me logo Genes that share domains with SLC35A4: view

Function for SLC35A4 Gene

Phenotypes From GWAS Catalog for SLC35A4 Gene

Gene Ontology (GO) - Molecular Function for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC35A4: view
genes like me logo Genes that share phenotypes with SLC35A4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC35A4

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35A4 Gene

Localization for SLC35A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35A4 Gene

Membrane; Single-pass membrane protein.
Golgi apparatus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35A4 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC35A4: view

Pathways & Interactions for SLC35A4 Gene

SuperPathways for SLC35A4 Gene

No Data Available

Interacting Proteins for SLC35A4 Gene

Gene Ontology (GO) - Biological Process for SLC35A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015992 proton transport IEA --
GO:0032056 positive regulation of translation in response to stress IDA --
genes like me logo Genes that share ontologies with SLC35A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC35A4 Gene

Drugs & Compounds for SLC35A4 Gene

No Compound Related Data Available

Transcripts for SLC35A4 Gene

Unigene Clusters for SLC35A4 Gene

Solute carrier family 35, member A4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC35A4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2: -
SP3:

Relevant External Links for SLC35A4 Gene

GeneLoc Exon Structure for
SLC35A4
ECgene alternative splicing isoforms for
SLC35A4

Expression for SLC35A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC35A4 Gene:

SLC35A4

SOURCE GeneReport for Unigene cluster for SLC35A4 Gene:

Hs.406840

Evidence on tissue expression from TISSUES for SLC35A4 Gene

  • Muscle(4.5)
  • Adrenal gland(4.3)
  • Nervous system(3.8)
  • Lung(2.8)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with SLC35A4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35A4 Gene

Orthologs for SLC35A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC35A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC35A4 33 34
  • 99.28 (n)
dog
(Canis familiaris)
Mammalia SLC35A4 33 34
  • 89.51 (n)
cow
(Bos Taurus)
Mammalia SLC35A4 33 34
  • 89.09 (n)
rat
(Rattus norvegicus)
Mammalia Slc35a4 33
  • 87.1 (n)
mouse
(Mus musculus)
Mammalia Slc35a4 33 16 34
  • 85.96 (n)
Gm5866 34
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC35A4 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC35A4 33
  • 64.29 (n)
lizard
(Anolis carolinensis)
Reptilia SLC35A4 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35a4 33
  • 57.28 (n)
Str.15202 33
zebrafish
(Danio rerio)
Actinopterygii slc35a4 33 34
  • 55.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14040 34
  • 19 (a)
OneToMany
Species where no ortholog for SLC35A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35A4 Gene

ENSEMBL:
Gene Tree for SLC35A4 (if available)
TreeFam:
Gene Tree for SLC35A4 (if available)

Paralogs for SLC35A4 Gene

Paralogs for SLC35A4 Gene

Pseudogenes.org Pseudogenes for SLC35A4 Gene

genes like me logo Genes that share paralogs with SLC35A4: view

Variants for SLC35A4 Gene

Sequence variations from dbSNP and Humsavar for SLC35A4 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000116414 -- 140,568,890(+) CTCTG(A/T)GGCTC utr-variant-3-prime
rs1000183069 -- 140,565,698(+) TCATT(C/T)GAATT intron-variant, upstream-variant-2KB
rs1000786513 -- 140,564,451(+) GGTGG(C/T)GCGTG upstream-variant-2KB, utr-variant-5-prime
rs1001071782 -- 140,564,687(+) GGTCA(C/T)GTGGA upstream-variant-2KB, utr-variant-5-prime
rs1001139894 -- 140,569,531(+) TTTCT(-/AAAA)AAAAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC35A4 Gene

Variant ID Type Subtype PubMed ID
nsv462462 CNV loss 19166990
nsv599825 CNV loss 21841781

Variation tolerance for SLC35A4 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.42; 54.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC35A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC35A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35A4 Gene

Disorders for SLC35A4 Gene

Relevant External Links for SLC35A4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC35A4

No disorders were found for SLC35A4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35A4 Gene

Publications for SLC35A4 Gene

  1. Translation of 5' leaders is pervasive in genes resistant to eIF2 repression. (PMID: 25621764) Andreev DE … Baranov PV (eLife 2015) 3 4 60
  2. An insight into the orphan nucleotide sugar transporter SLC35A4. (PMID: 28167211) Sosicka P … Olczak M (Biochimica et biophysica acta 2017) 3 60
  3. Direct detection of alternative open reading frames translation products in human significantly expands the proteome. (PMID: 23950983) Vanderperre B … Roucou X (PloS one 2013) 4 60
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 60
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 60

Products for SLC35A4 Gene

Sources for SLC35A4 Gene

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