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SLC35A2 Gene

protein-coding   GIFtS: 56
GCID: GC0XM048760

Solute Carrier Family 35 (UDP-Galactose Transporter), Member...

(Previous names: solute carrier family 35 (UDP-galactose transporter), member...)
(Previous symbol: UGALT)
  See SLC35A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35 (UDP-Galactose Transporter), Member A21 2     CDGX2 5
UGALT1 2 3 5     UGT22 5
UGTL2 3 5     UGAT2
Solute Carrier Family 35 (UDP-Galactose Transporter), Member 21 2     UGT12
UDP-Gal-Tr2 3     UDP-Galactose Translocator2
UGT2 3     Solute Carrier Family 35 Member A23
CDG2M2 5     UDP-Galactose Transporter3

External Ids:    HGNC: 110221   Entrez Gene: 73552   Ensembl: ENSG000001021007   OMIM: 3143755   UniProtKB: P783813   

Export aliases for SLC35A2 gene to outside databases

Previous GC identifers: GC0XM047563 GC0XM047021 GC0XM047806 GC0XM048516 GC0XM048645 GC0XM046416


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC35A2 Gene:
SLC35A2 (solute carrier family 35 (UDP-galactose transporter), member A2) is a protein-coding gene. Diseases associated with SLC35A2 include urogenital tuberculosis, and hepatitis d. GO annotations related to this gene include UDP-galactose transmembrane transporter activity and sugar:hydrogen symporter activity. An important paralog of this gene is SLC35A1.

UniProtKB/Swiss-Prot: S35A2_HUMAN, P78381
Function: Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function

Gene Wiki entry for SLC35A2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_079573.5  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC35A2 gene promoter:
         C/EBPbeta   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC35A2 promoter sequence
   Search Chromatin IP Primers for SLC35A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23-p11.22   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23-p11.22

SLC35A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35A2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM048760:  view genomic region     (about GC identifiers)

Start:
48,760,459 bp from pter      End:
48,769,235 bp from pter
Size:
8,777 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: S35A2_HUMAN, P78381 (See protein sequence)
Recommended Name: UDP-galactose translocator  
Size: 396 amino acids; 41307 Da
Secondary accessions: A8K2L9 A8K9V1 Q8IV21 Q92553
Alternative splicing: 3 isoforms:  P78381-1   P78381-2   P78381-3   

Explore the universe of human proteins at neXtProt for SLC35A2: NX_P78381

Explore proteomics data for SLC35A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC35A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001035963.1  NP_001027460.1  NP_001269576.1  NP_001269577.1  NP_001269578.1  NP_001269579.1  NP_001269580.1  NP_005651.1  

    ENSEMBL proteins: 
     ENSP00000247138   ENSP00000365712   ENSP00000365704   ENSP00000402726   ENSP00000365698  
     ENSP00000415518   ENSP00000365695   ENSP00000393233   ENSP00000416002  
    Reactome Protein details: P78381

    SLC35A2 Human Recombinant Protein Products:

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    Novus Biologicals SLC35A2 Proteins
    Novus Biologicals SLC35A2 Lysate
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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    Search eBioscience for ELISAs for SLC35A2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: UDP-galactose transporter
    SLC35 family of nucleotide sugar transporters

    3 InterPro protein domains:
     IPR004689 UDPgal_transpt
     IPR007271 Nuc_sug_transpt
     IPR021189 UDP/CMP-sugar_transptr

    Graphical View of Domain Structure for InterPro Entry P78381

    ProtoNet protein and cluster: P78381

    1 Blocks protein domain: IPB007271 Nucleotide-sugar transporter

    UniProtKB/Swiss-Prot: S35A2_HUMAN, P78381
    Similarity: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily


    Find genes that share domains with SLC35A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35A2_HUMAN, P78381
    Function: Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005338nucleotide-sugar transmembrane transporter activity ----
    GO:0005351sugar:hydrogen symporter activity IEA--
    GO:0005459UDP-galactose transmembrane transporter activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with SLC35A2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC35A2
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC35A2 (see all 22):
    hsa-miR-100* hsa-miR-429 hsa-miR-2110 hsa-miR-1271 hsa-miR-4260 hsa-miR-3150a-3p hsa-miR-383 hsa-miR-7-1*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S35A2_HUMAN, P78381: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    nucleus4
    plasma membrane3
    cytosol2
    endoplasmic reticulum2
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC35A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC35A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of nucleotide sugars0.00


    Find genes that share SuperPaths with SLC35A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC35A2
        Transport of nucleotide sugars


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC35A2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for SLC35A2 (P783811, 2, 3 ENSP000002471384) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC35A3Q9Y2D21, 2EBI-8101118,EBI-3917581 MINT-8397321 MINT-8397364 MINT-8397427 MINT-8397308 MINT-8397348
    PLSCR1O151623, ENSP000003454944I2D: score=4 STRING: ENSP00000345494
    MDFIQ997503, ENSP000002303214I2D: score=4 STRING: ENSP00000230321
    LIMK1P536673I2D: score=2 
    SLC35A2P783812MINT-8397334
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006012galactose metabolic process TAS9010752
    GO:0006810transport ----
    GO:0008643carbohydrate transport ----
    GO:0015780nucleotide-sugar transport ----
    GO:0015785UDP-galactose transport TAS9010752

    Find genes that share ontologies with SLC35A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC35A2 (S35A2)

    3 Novoseek inferred chemical compound relationships for SLC35A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 92.2 53 9446560 (4), 10371208 (3), 12925779 (3), 9399569 (3) (see all 24)
    udp-n-acetylglucosamine 76.3 1 10393322 (1)
    galactose 68.4 7 12655085 (3), 9364878 (1), 9446560 (1)

    1 PharmGKB related drug/compound annotation for SLC35A2 gene    About this table
    Drug/compound PharmGKB Annotation
    dabrafenib



    Find genes that share compounds with SLC35A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC35A2 gene (8 alternative transcripts): 
    NM_001042498.2  NM_001032289.2  NM_001282647.1  NM_001282648.1  NM_001282649.1  NM_001282650.1  NM_001282651.1  NM_005660.2  

    Unigene Cluster for SLC35A2:

    Solute carrier family 35 (UDP-galactose transporter), member A2
    Hs.21899  [show with all ESTs]
    Unigene Representative Sequence: D84454
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000247138 ENST00000376529 ENST00000376521(uc004dlr.1 uc011mml.1 uc004dlo.1 uc004dlp.1 uc011mmm.1 uc011mmn.1 uc004dlq.3)
    ENST00000445167 ENST00000376515 ENST00000446885 ENST00000376512(uc011mmo.1)
    ENST00000413561 ENST00000452555
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC35A2 (see all 22):
    hsa-miR-100* hsa-miR-429 hsa-miR-2110 hsa-miR-1271 hsa-miR-4260 hsa-miR-3150a-3p hsa-miR-383 hsa-miR-7-1*
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC35A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC35A2

    Additional mRNA sequence: 

    AK090730.1 AK225508.1 AK290284.1 AK292816.1 AK293415.1 AK293419.1 AK298484.1 AK299748.1 
    BC035747.1 CR450287.1 D84454.1 D88146.1 

    16 DOTS entries:

    DT.101956108  DT.100887149  DT.40118218  DT.95174452  DT.75188907  DT.121324645  DT.100039308  DT.121324816 
    DT.121324654  DT.454653  DT.97822613  DT.121324704  DT.121324691  DT.121324705  DT.91811189  DT.97829458 

    Selected AceView cDNA sequences (see all 270):

    BE552397 BG115555 AI679866 BP375886 BM837811 AW008109 AW000922 CB140525 
    CR596762 BG742054 BQ691813 BG055868 BM828130 BQ008050 BX399954 AW951376 
    D88146 H14218 AI569603 BP359142 W25657 BM837372 BU849756 CD370036 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A2 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d · 5e ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a ·
    SP1:                                                  -     -                                         -     -     -                                             
    SP2:                                                  -     -     -                                   -     -     -                                   -         
    SP3:                                                  -     -     -                                   -     -     -     -     -     -     -           -         
    SP4:              -     -     -     -     -     -     -     -     -                                   -     -     -     -     -     -     -                     
    SP5:                                                  -     -     -                                   -     -     -                                             

    ExUns: 9b
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SLC35A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC35A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC35A2 Expression
    About this image

    SLC35A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC35A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.21899
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC35A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC35A2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35a25 solute carrier family 35 (UDP-galactose transporter), more   --   X (3.56 cM) 7884041 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35A26
    solute carrier family 35 (UDP-galactose transporte...
    69(a)
    1 ↔ 1
    GL343326.1(1332081-1347758)
    zebrafish
    (Danio rerio)
    Actinopterygii SLC35A26
    solute carrier family 35 (UDP-galactose transporte...
    61(a)
    1 ↔ 1
    8(9492456-9515619) ENSDARG00000058990
    fruit fly
    (Drosophila melanogaster)
    Insecta Csat3 NOT CMP-sialic acid transport
    UDP-galactose transporter
    50(a)   1 3B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea ZK896.93
    nstp-51
    CMP-sialic acid transporter3
    nstp-51
    42(a)
    (best of 5)3
    52.29(n)1
    49.52(a)1
      IV(12855728-12859545)3
    1914521  NM_001268750.11  NP_001255679.11 


    ENSEMBL Gene Tree for SLC35A2 (if available)
    TreeFam Gene Tree for SLC35A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC35A2 gene
    SLC35A12  SLC35A42  SLC35A32  SLC35A52  
    3 SIMAP similar genes for SLC35A2 using alignment to 8 protein entries:     S35A2_HUMAN (see all proteins):
    SLC35A3    DKFZp566I1346    SLC35A1

    Find genes that share paralogs with SLC35A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC35A2 (see all 116)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0365794
    A breast cancer sample4--see VAR_0365792 W C mis40--------
    VAR_0697734
    Congenital disorder of glycosylation 2M (CDG2M)4--see VAR_0697732 V I mis40--------
    rs1898392021,2
    --48760964(+) CAAACC/TAAAAA 3 -- int1 ut310--------
    rs59057151,2
    C--48761059(+) CACACA/CCCGCC 3 -- int1 ut31 ese30--------
    rs1818189811,2
    --48761099(+) GGGGAA/GCGCAG 3 -- int1 ut310--------
    rs1384189071,2
    C--48761251(+) TGACAA/GTGTCT 3 -- int1 ut310--------
    rs1869769061,2
    --48761369(+) TGGCCC/TCTACC 3 -- int1 ut310--------
    rs1413761201,2
    C--48761434(+) CTGGGA/GACTCA 3 -- int1 ut310--------
    rs1434171681,2
    --48761494(+) AAAGAC/TGGAAC 3 -- int1 ut310--------
    rs1381900201,2
    C,F--48762108(+) GTGAAC/TGCAGG 6 I V H R mis11Minor allele frequency- T:0.00NA 4380

    HapMap Linkage Disequilibrium report for SLC35A2 (48760459 - 48769235 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC35A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6894CNV Insertion18451855
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): SLC35A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 314375   
    OMIM disorders: 300896  
    UniProtKB/Swiss-Prot: S35A2_HUMAN, P78381
  • Congenital disorder of glycosylation 2M (CDG2M) [MIM:300896]: A disorder characterized by developmental
    delay, hypotonia, ocular anomalies, and brain malformations. Othere more variable clinical features included
    seizures, hypsarrhythmia, poor feeding, microcephaly, recurrent infections, dysmorphic features, shortened limbs,
    and coagulation defects. Congenital disorders of glycosylation are caused by a defect in glycoprotein
    biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features.
    The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development,
    differentiation, and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 5 diseases for SLC35A2:    
    About MalaCards
    urogenital tuberculosis    hepatitis d    congenital disorder of glycosylation, type iim    bilirubin metabolic disorder
    kernicterus

    4 diseases from the University of Copenhagen DISEASES database for SLC35A2:
    Bilirubin metabolic disorder     Urogenital tuberculosis     Hepatitis D     Kernicterus

    Find genes that share disorders with SLC35A2           About GenesLikeMe

    2 Novoseek inferred disease relationships for SLC35A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    encephalomyelitis 26.9 1 12655085 (1)
    cancer 0 1 15141079 (1)


    Export disorders for SLC35A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC35A2 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with SLC35A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. (PubMed id 8128316)1, 2, 3 Hara T....Kawakita M. (Somat. Cell Mol. Genet. 1993)
    2. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PubMed id 9010752)1, 2, 9 Ishida N.... Kawakita M. (J. Biochem. 1996)
    3. Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator. (PubMed id 8889805)1, 2, 9 Miura N....Kawakita M. (J. Biochem. 1996)
    4. Mosaicism of the UDP-galactose transporter SLC35A2 causes a congenital disorder of glycosylation. (PubMed id 23561849)1, 2 Ng B.G....Freeze H.H. (Am. J. Hum. Genet. 2013)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. (PubMed id 12925779)1, 9 Sprong H....van Meer G. (Mol. Biol. Cell 2003)
    7. Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid. (PubMed id 11279205)1, 9 Aoki K....Kawakita M. (J. Biol. Chem. 2001)
    8. Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter. (PubMed id 9399569)1, 9 Yoshioka S....Kawakita M. (J. Biochem. 1997)
    9. UDP-Gal/UDP-GlcNAc chimeric transporter complements mutation defect in mammalian cells deficient in UDP-Gal transporter. (PubMed id 23583405)1 Olczak M....Olczak T. (Biochem. Biophys. Res. Commun. 2013)
    10. Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters. (PubMed id 21918738)1 Maszczak-Seneczko D....Olczak M. (Acta Biochim. Pol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7355 HGNC: 11022 AceView: SLC35A2 Ensembl:ENSG00000102100 euGenes: HUgn7355
    ECgene: SLC35A2 H-InvDB: SLC35A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC35A2 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=SLC35A2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC35A2 gene:
    Search GeneIP for patents involving SLC35A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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