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SLC35A1 Gene

protein-coding   GIFtS: 51
GCID: GC06P088180

Solute Carrier Family 35 (CMP-Sialic Acid Transporter),...

(Previous names: solute carrier family 35 (UDP-galactose transporter), member...)
  See SLC35A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 35 (CMP-Sialic Acid Transporter), Member A11 2     CST2 5
Solute Carrier Family 35 (UDP-Galactose Transporter), Member 11 2     CMPST2
Solute Carrier Family 35 Member A12 3     CMP-Sialic Acid Transporter2
CMP-SA-Tr2 3     hCST2
CMP-Sia-Tr2 3     Mutated CMP-Sialic Acid Transporter A12
CDG2F2 5     Solute Carrier Family 35 (CMP-Sialic Acid Transporter), Member 12

External Ids:    HGNC: 110211   Entrez Gene: 105592   Ensembl: ENSG000001644147   OMIM: 6056345   UniProtKB: P783823   

Export aliases for SLC35A1 gene to outside databases

Previous GC identifers: GC06P088126 GC06P088178 GC06P088239 GC06P085398


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC35A1 Gene:
The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide
sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the
encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of
glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this
gene.(provided by RefSeq, Dec 2009)

GeneCards Summary for SLC35A1 Gene:
SLC35A1 (solute carrier family 35 (CMP-sialic acid transporter), member A1) is a protein-coding gene. Diseases associated with SLC35A1 include congenital disorder of glycosylation, type iif, and sialuria. GO annotations related to this gene include CMP-N-acetylneuraminate transmembrane transporter activity and sugar:hydrogen symporter activity. An important paralog of this gene is SLC35A2.

UniProtKB/Swiss-Prot: S35A1_HUMAN, P78382
Function: Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function

Gene Wiki entry for SLC35A1 (Solute carrier family 35, member A1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC35A1 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Roaz   C/EBPalpha   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC35A1 promoter sequence
   Search Chromatin IP Primers for SLC35A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC35A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

SLC35A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC35A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P088180:  view genomic region     (about GC identifiers)

Start:
88,180,341 bp from pter      End:
88,222,057 bp from pter
Size:
41,717 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: S35A1_HUMAN, P78382 (See protein sequence)
Recommended Name: CMP-sialic acid transporter  
Size: 337 amino acids; 36779 Da
Secondary accessions: Q5W1L8
Alternative splicing: 2 isoforms:  P78382-1   P78382-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC35A1: NX_P78382

Explore proteomics data for SLC35A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC35A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161870.1  NP_006407.1  

    ENSEMBL proteins: 
     ENSP00000358565   ENSP00000358569   ENSP00000358570   ENSP00000438603  
    Reactome Protein details: P78382

    SLC35A1 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: CMP-sialic acid transporter
    SLC35 family of nucleotide sugar transporters

    3 InterPro protein domains:
     IPR004689 UDPgal_transpt
     IPR007271 Nuc_sug_transpt
     IPR021189 UDP/CMP-sugar_transptr

    Graphical View of Domain Structure for InterPro Entry P78382

    ProtoNet protein and cluster: P78382

    1 Blocks protein domain: IPB007271 Nucleotide-sugar transporter

    UniProtKB/Swiss-Prot: S35A1_HUMAN, P78382
    Similarity: Belongs to the nucleotide-sugar transporter family. SLC35A subfamily


    Find genes that share domains with SLC35A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: S35A1_HUMAN, P78382
    Function: Transports CMP-sialic acid from the cytosol into Golgi vesicles where glycosyltransferases function

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005338nucleotide-sugar transmembrane transporter activity ----
    GO:0005351sugar:hydrogen symporter activity IEA--
    GO:0005456CMP-N-acetylneuraminate transmembrane transporter activity TAS9644260
         
    Find genes that share ontologies with SLC35A1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC35A1:
     Decreased influenza A virus in 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Slc35a1):
     mortality/aging 

    Find genes that share phenotypes with SLC35A1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC35A1

    miRNA
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    miRTarBase miRNAs that target SLC35A1:
    hsa-mir-16-5p (MIRT000905), hsa-mir-15a-5p (MIRT000906)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    S35A1_HUMAN, P78382: Golgi apparatus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane4
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus TAS9644260
    GO:0005887integral component of plasma membrane TAS9644260
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC35A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC35A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transmembrane transport of small molecules0.47
    2Transport of vitamins, nucleosides, and related molecules
    Transport of vitamins, nucleosides, and related molecules
    Transport of nucleotide sugars0.00


    Find genes that share SuperPaths with SLC35A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC35A1
        Sialic acid metabolism
    Transport of nucleotide sugars


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC35A1
    Interactions:

        Search GeneGlobe Interaction Network for SLC35A1

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS9644260
    GO:0006464cellular protein modification process TAS9644260
    GO:0008643carbohydrate transport ----
    GO:0015780nucleotide-sugar transport ----
    GO:0015782CMP-N-acetylneuraminate transport TAS9644260

    Find genes that share ontologies with SLC35A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SLC35A1 (S35A1)

    2 Novoseek inferred chemical compound relationships for SLC35A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 84.8 10 10544289 (2), 11279205 (2), 9125114 (1), 12682060 (1) (see all 6)
    udp-n-acetylglucosamine 80 2 9010752 (1), 16434112 (1)



    Find genes that share compounds with SLC35A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC35A1 gene (2 alternative transcripts): 
    NM_001168398.1  NM_006416.4  

    Unigene Cluster for SLC35A1:

    Solute carrier family 35 (CMP-sialic acid transporter), member A1
    Hs.423163  [show with all ESTs]
    Unigene Representative Sequence: NM_006416
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000464978 ENST00000369552(uc003plx.3 uc010kbw.3 uc011dzj.2 uc003plz.3 uc011dzi.2 uc003ply.3)
    ENST00000369556(uc010kbx.3 uc010kby.3) ENST00000369557 ENST00000544441

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    Selected qRT-PCR Assays for microRNAs that regulate SLC35A1 (see all 14):
    hsa-miR-205 hsa-miR-137 hsa-miR-561 hsa-miR-200a hsa-miR-183 hsa-miR-1271 hsa-miR-1912 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidSLC35A1 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat SLC35A1

    Additional mRNA sequence: 

    AJ810302.1 AJ851888.1 AK293696.1 AK299432.1 BC008372.1 BC017807.1 D87969.1 

    16 DOTS entries:

    DT.454595  DT.97775060  DT.91741163  DT.121375851  DT.100815915  DT.100815920  DT.40117274  DT.95254119 
    DT.100815914  DT.100815918  DT.121375958  DT.92432921  DT.100670157  DT.100737409  DT.92005777  DT.99954891 

    Selected AceView cDNA sequences (see all 211):

    BX951396 BQ024221 AI932726 AK093830 AA781229 CD678741 CB162056 AX748329 
    CD558020 AW205658 AA460853 AL542048 BG778614 CR626359 BM756875 AW134591 
    CB242593 NM_178823 CA313127 AA290699 CR618258 AA251703 BM728252 AW467412 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC35A1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b
    SP1:              -                       -                                                           -     -     -                     
    SP2:              -                       -                                                                                             
    SP3:              -                       -                                                                                             
    SP4:              -                                                                                                                     
    SP5:                                      -                                                                                             


    ECgene alternative splicing isoforms for SLC35A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC35A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACAGTATTT
    SLC35A1 Expression
    About this image

    SLC35A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC35A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.423163
        Custom PCR Arrays for SLC35A1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for SLC35A1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc35a11 , 5 solute carrier family 35 (CMP-sialic acid transporter), more1, 5 87.6(n)1
    91.67(a)1
      4 (16.86 cM)5
    240601  NM_011895.31  NP_036025.21 
     346632575 
    chicken
    (Gallus gallus)
    Aves SLC35A11 solute carrier family 35 (CMP-sialic acid transporter), more 77.35(n)
    84.57(a)
      395184  NM_204513.1  NP_989844.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC35A16
    solute carrier family 35 (CMP-sialic acid transpor...
    84(a)
    1 ↔ 1
    1(176360525-176377312)
    zebrafish
    (Danio rerio)
    Actinopterygii slc35a11 solute carrier family 35 (CMP-sialic acid transporter), more 67.17(n)
    77.11(a)
      100004536  NM_001128811.1  NP_001122283.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ZK370.73
    ugtp-11
    ugtp-11 39(a)
    (best of 5)3
    51.58(n)1
    40.98(a)1
      III(8818182-8820422)3
    1762271  NM_066529.51  NP_498930.11 


    ENSEMBL Gene Tree for SLC35A1 (if available)
    TreeFam Gene Tree for SLC35A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC35A1 gene
    SLC35A22  SLC35A42  SLC35A32  SLC35A52  
    3 SIMAP similar genes for SLC35A1 using alignment to 6 protein entries:     S35A1_HUMAN (see all proteins):
    DKFZp566I1346    SLC35A3    SLC35A2

    Find genes that share paralogs with SLC35A1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC35A1 (see all 891)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2005935071,2
    C--85422730(+) AAAAAA/CAAAGA 2 -- int10--------
    rs2001390871,2
    --85422734(+) AAAAA-/AGAAAAA 2 -- int10--------
    rs77638771,2
    C,F,H--85422735(+) AAAAAA/C/GAAAAA 2 -- int1 trp34WA NA CSA 7
    rs665194311,2
    C--85423140(+) TCTGT-/CTTTTTTT 2 -- cds10--------
    rs743603141,2
    C--85423140(+) CTCTGC/TTTTTT 2 -- int11Minor allele frequency- T:0.00CSA 1
    rs342929451,2
    C--85425544(+) TAGAG-/ATATAGT 2 -- int10--------
    rs1140525121,2
    F--85438387(+) TGGAAG/ATCTAT 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1810178771,2
    --85438394(+) CTATCC/GGTTAG 2 -- ds50010--------
    rs1399098171,2
    C--85438402(+) AGGGT-/TCTC  
            
    TCTCT
    2 -- ds50010--------
    rs1848941881,2
    --85438405(+) GGTTCC/TCTGGC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC35A1 (88180341 - 88222057 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC35A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830722CNV Gain17160897

    Human Gene Mutation Database (HGMD): SLC35A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC35A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC35A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 605634   
    OMIM disorders: 603585  
    UniProtKB/Swiss-Prot: S35A1_HUMAN, P78382
  • Congenital disorder of glycosylation 2F (CDG2F) [MIM:603585]: CDGs are a family of severe inherited
    diseases caused by a defect in protein N-glycosylation. They are characterized by under-glycosylated serum
    proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the
    nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and
    immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic
    development, differentiation, and maintenance of cell functions. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 2 diseases for SLC35A1:    
    About MalaCards
    congenital disorder of glycosylation, type iif    sialuria

    2 diseases from the University of Copenhagen DISEASES database for SLC35A1:
    Sialuria     Congenital disorder of glycosylation

    Find genes that share disorders with SLC35A1           About GenesLikeMe

    GeneTests: SLC35A1
    GeneReviews: SLC35A1

    Export disorders for SLC35A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC35A1 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with SLC35A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. (PubMed id 9010752)1, 2, 3, 9 Ishida N.... Kawakita M. (J. Biochem. 1996)
    2. Functional expression of human golgi CMP-sialic acid transporter in the Golgi complex of a transporter-deficient Chinese hamster ovary cell mutant. (PubMed id 9644260)1, 3, 9 Ishida N....Kawakita M. (J. Biochem. 1998)
    3. Genetic complementation reveals a novel human congenital disorder of glycosylation of type II, due to inactivation of the Golgi CMP-sialic acid transporter. (PubMed id 15576474)1, 2 Martinez-Duncker I.... Mollicone R. (Blood 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Substrate recognition by nucleotide sugar transporters: further characterization of substrate recognition regions by analyses of UDP-galactose/CMP-sialic acid transporter chimeras and biochemical analysis of the substrate specificity of parental and chimeric transporters. (PubMed id 12682060)1, 9 Aoki K....Kawakita M. (J. Biol. Chem. 2003)
    7. Expression of human CMP-N-acetylneuraminic acid synthetase and CMP-sialic acid transporter in tobacco suspension-cultured cell. (PubMed id 16343442)1, 9 Misaki R....Seki T. (Biochem. Biophys. Res. Commun. 2006)
    8. Intellectual disability and bleeding diathesis due to deficient CMP--sialic acid transport. (PubMed id 23873973)1 Mohamed M....Morava E. (Neurology 2013)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10559 HGNC: 11021 AceView: SLC35A1andC6orf165 Ensembl:ENSG00000164414 euGenes: HUgn10559
    ECgene: SLC35A1 H-InvDB: SLC35A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC35A1 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=SLC35A1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC35A1 gene:
    Search GeneIP for patents involving SLC35A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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