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Aliases for SLC34A2 Gene

Aliases for SLC34A2 Gene

  • Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 2 2 3
  • Solute Carrier Family 34 (Sodium Phosphate), Member 2 2 3
  • Sodium/Phosphate Cotransporter 2B 3 4
  • Type II Sodium-Dependent Phosphate Transporter 3b 3
  • Sodium-Dependent Phosphate Transport Protein 2B 3
  • Na(+)-Dependent Phosphate Cotransporter 2B 4
  • Sodium-Phosphate Transport Protein 2B 4
  • Solute Carrier Family 34 Member 2 4
  • Na(+)/Pi Cotransporter 2B 4
  • NAPI-IIb 3
  • NAPI-3B 3
  • NaPi-2b 4
  • NPTIIb 3
  • NaPi3b 4

External Ids for SLC34A2 Gene

Previous GeneCards Identifiers for SLC34A2 Gene

  • GC04P025772
  • GC04P025345
  • GC04P025408
  • GC04P025333
  • GC04P025266
  • GC04P024995

Summaries for SLC34A2 Gene

Entrez Gene Summary for SLC34A2 Gene

  • The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for SLC34A2 Gene

SLC34A2 (Solute Carrier Family 34 (Type II Sodium/Phosphate Cotransporter), Member 2) is a Protein Coding gene. Diseases associated with SLC34A2 include pulmonary alveolar microlithiasis and testicular microlithiasis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include phosphate ion binding and sodium-dependent phosphate transmembrane transporter activity. An important paralog of this gene is SLC34A1.

UniProtKB/Swiss-Prot for SLC34A2 Gene

  • May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs alveoli

Gene Wiki entry for SLC34A2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC34A2 Gene

Genomics for SLC34A2 Gene

Regulatory Elements for SLC34A2 Gene

Genomic Location for SLC34A2 Gene

25,655,301 bp from pter
25,678,748 bp from pter
23,448 bases
Plus strand

Genomic View for SLC34A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC34A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC34A2 Gene

Proteins for SLC34A2 Gene

  • Protein details for SLC34A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sodium-dependent phosphate transport protein 2B
    Protein Accession:
    Secondary Accessions:
    • A5PL17
    • Q8N2K2
    • Q8WYA9
    • Q9P0V7

    Protein attributes for SLC34A2 Gene

    690 amino acids
    Molecular mass:
    75759 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC34A2 Gene


neXtProt entry for SLC34A2 Gene

Proteomics data for SLC34A2 Gene at MOPED

Post-translational modifications for SLC34A2 Gene

  • Glycosylation at Asn295, Asn308, Asn313, Asn321, and Asn340
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC34A2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SLC34A2 (SLC34A2)

No data available for DME Specific Peptides for SLC34A2 Gene

Domains for SLC34A2 Gene

Gene Families for SLC34A2 Gene

Protein Domains for SLC34A2 Gene

Suggested Antigen Peptide Sequences for SLC34A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O95436
  • Belongs to the SLC34A transporter family.
genes like me logo Genes that share domains with SLC34A2: view

Function for SLC34A2 Gene

Molecular function for SLC34A2 Gene

GENATLAS Biochemistry:
solute carrier family 34 (sodium/phosphate cotransport) member A2, (brain)
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.6. {ECO:0000269 PubMed:10329428};
UniProtKB/Swiss-Prot Function:
May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs alveoli
UniProtKB/Swiss-Prot Induction:
Down-regulated by EGF.

Gene Ontology (GO) - Molecular Function for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005436 sodium:phosphate symporter activity IDA 10329428
GO:0005524 ATP binding --
GO:0015321 sodium-dependent phosphate transmembrane transporter activity IDA 10329428
GO:0019904 protein domain specific binding IEA --
GO:0031402 sodium ion binding IDA 12488042
genes like me logo Genes that share ontologies with SLC34A2: view
genes like me logo Genes that share phenotypes with SLC34A2: view

Animal Models for SLC34A2 Gene

MGI Knock Outs for SLC34A2:

Animal Model Products

CRISPR Products

miRNA for SLC34A2 Gene

miRTarBase miRNAs that target SLC34A2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC34A2 Gene

Localization for SLC34A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC34A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC34A2 Gene COMPARTMENTS Subcellular localization image for SLC34A2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10329428
GO:0005903 brush border --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10610722
genes like me logo Genes that share ontologies with SLC34A2: view

Pathways for SLC34A2 Gene

genes like me logo Genes that share pathways with SLC34A2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for SLC34A2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000371483 for SLC34A2 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for SLC34A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006817 phosphate ion transport IDA 10329428
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with SLC34A2: view

Compounds for SLC34A2 Gene

(2) HMDB Compounds for SLC34A2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • NFB Orthophosphate

(1) Novoseek inferred chemical compound relationships for SLC34A2 Gene

Compound -log(P) Hits PubMed IDs
actinomycin d 42.3 1
genes like me logo Genes that share compounds with SLC34A2: view

Transcripts for SLC34A2 Gene

Unigene Clusters for SLC34A2 Gene

Solute carrier family 34 (sodium phosphate), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC34A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC34A2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP3: -

Relevant External Links for SLC34A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC34A2 Gene

mRNA expression in normal human tissues for SLC34A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC34A2 Gene

This gene is overexpressed in Lung (31.0) and Minor Salivary Gland (10.9).

Protein differential expression in normal tissues for SLC34A2 Gene

This gene is overexpressed in Lung (33.8) and Milk (19.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for SLC34A2 Gene

SOURCE GeneReport for Unigene cluster for SLC34A2 Gene Hs.479372

mRNA Expression by UniProt/SwissProt for SLC34A2 Gene

Tissue specificity: Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium.
genes like me logo Genes that share expressions with SLC34A2: view

In Situ Assay Products

No data available for Expression partners for SLC34A2 Gene

Orthologs for SLC34A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC34A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC34A2 35
  • 80.9 (n)
  • 76.82 (a)
SLC34A2 36
  • 75 (a)
(Canis familiaris)
Mammalia SLC34A2 35
  • 80.97 (n)
  • 79.44 (a)
SLC34A2 36
  • 78 (a)
(Mus musculus)
Mammalia Slc34a2 35
  • 80.72 (n)
  • 80.33 (a)
Slc34a2 16
Slc34a2 36
  • 77 (a)
(Pan troglodytes)
Mammalia SLC34A2 35
  • 99.28 (n)
  • 99.28 (a)
SLC34A2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc34a2 35
  • 81.11 (n)
  • 80.62 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
-- 36
  • 53 (a)
-- 36
  • 74 (a)
-- 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia SLC34A2 36
  • 66 (a)
(Gallus gallus)
Aves SLC34A2 35
  • 65.54 (n)
  • 65.08 (a)
SLC34A2 36
  • 62 (a)
(Anolis carolinensis)
Reptilia SLC34A2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc34a2 35
  • 61.22 (n)
  • 62.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5596 35
(Danio rerio)
Actinopterygii slc34a2b 35
  • 64.25 (n)
  • 63.15 (a)
slc34a2a 36
  • 61 (a)
slc34a2b 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea ZK563.2 37
  • 40 (a)
ZK563.2 36
  • 32 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1462 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
-- 36
  • 49 (a)
-- 36
  • 50 (a)
-- 36
  • 44 (a)
Species with no ortholog for SLC34A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC34A2 Gene

Gene Tree for SLC34A2 (if available)
Gene Tree for SLC34A2 (if available)

Paralogs for SLC34A2 Gene

Paralogs for SLC34A2 Gene

Selected SIMAP similar genes for SLC34A2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC34A2: view

Variants for SLC34A2 Gene

Sequence variations from dbSNP and Humsavar for SLC34A2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1052898 -- 25,678,218(+) AGACA(A/G)TCCTC utr-variant-3-prime
rs1132584 -- 25,678,628(+) cgccc(A/C)cctca utr-variant-3-prime
rs1132601 -- 25,678,671(+) ccacc(A/C)ccagg utr-variant-3-prime
rs2240995 -- 25,673,377(+) CAGCA(C/G)CAGAA intron-variant
rs2240996 -- 25,673,478(+) CTGAG(A/C)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC34A2 Gene

Variant ID Type Subtype PubMed ID
nsv878761 CNV Gain 21882294
nsv878765 CNV Gain 21882294
nsv526729 CNV Loss 19592680
nsv507156 CNV Insertion 20534489

Relevant External Links for SLC34A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC34A2 Gene

Disorders for SLC34A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC34A2 Gene in MalaCards »

(2) Diseases for SLC34A2 Gene including...

(2) OMIM Diseases for SLC34A2 Gene (604217)


  • Pulmonary alveolar microlithiasis (PALM) [MIM:265100]: Rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early-onset or rapid progression are rare. A sandstorm-appearing chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. {ECO:0000269 PubMed:16960801}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. {ECO:0000269 PubMed:12661006}.

(1) University of Copenhagen DISEASES for SLC34A2 Gene

Relevant External Links for SLC34A2

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC34A2: view

No data available for Novoseek inferred disease relationships and Genatlas for SLC34A2 Gene

Publications for SLC34A2 Gene

  1. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium- phosphate (Na+-Pi) transporter (SLC34A2). (PMID: 10610722) Xu H. … Ghishan F.K. (Genomics 1999) 2 3 4 23
  2. Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor. (PMID: 11171583) Xu H. … Ghishan F.K. (Am. J. Physiol. 2001) 3 4 23
  3. Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. (PMID: 10329428) Feild J.A. … Edwards R.M. (Biochem. Biophys. Res. Commun. 1999) 2 3 4
  4. Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. (PMID: 12893629) Xu H. … Ghishan F.K. (Am. J. Physiol. Gastrointest. Liver Physiol. 2003) 3 23
  5. Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. (PMID: 16960801) Corut A. … Tolun A. (Am. J. Hum. Genet. 2006) 3 4

Products for SLC34A2 Gene

Sources for SLC34A2 Gene

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