Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC34A2 Gene

protein-coding   GIFtS: 57
GCID: GC04P025657

solute carrier family 34 (sodium phosphate), member 2
 Explore 9 diseases affiliated with
SLC34A2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC34A2    

Aliases
for SLC34A2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 34 (Sodium Phosphate), Member 21 2     NaPi-2b3
NAPI-3B1 2     NaPi3b3
Sodium/Phosphate Cotransporter 2B2 3     Na(+)-Dependent Phosphate Cotransporter 2B3
NAPI-IIb2     Na(+)/Pi Cotransporter 2B3
NPTIIb2     Sodium-Phosphate Transport Protein 2B3
Sodium-Dependent Phosphate Transport Protein 2B2     Solute Carrier Family 34 Member 23
Type II Sodium-Dependent Phosphate Transporter 3b2     

External Ids:    HGNC: 110201   Entrez Gene: 105682   Ensembl: ENSG000001577657   OMIM: 6042175   UniProtKB: O954363   

Export aliases for SLC34A2 gene to outside databases

Previous GC identifers: GC04P025772 GC04P025345 GC04P025408 GC04P025333 GC04P025266 GC04P024995


Summaries
for SLC34A2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for SLC34A2:
The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is
increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript
variants encoding two different isoforms have been found for this gene. (provided by RefSeq, May 2010)

UniProtKB/Swiss-Prot: NPT2B_HUMAN, O95436
Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main
phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in
lungs' alveoli

Gene Wiki entry for SLC34A2


Genomic Views
for SLC34A2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_006316.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC34A2 gene promoter:
         ER-alpha   Sox5   AML1a   Lmo2   LCR-F1   E47   HSF2   c-Myb   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC34A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC34A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC34A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.2   Ensembl cytogenetic band:  4p15.2   HGNC cytogenetic band: 4p15.2

SLC34A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC34A2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P025657:  view genomic region     (about GC identifiers)

Start:
 25,656,923 bp from pter      End:
 25,680,370 bp from pter
Size:
 23,448 bases      Orientation:
 plus strand

Proteins
for SLC34A2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: NPT2B_HUMAN, O95436 (See protein sequence)
Recommended Name: Sodium-dependent phosphate transport protein 2B  
Size: 690 amino acids; 75759 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAC11354.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A5PL17 Q8N2K2 Q8WYA9 Q9P0V7
Alternative splicing: 2 isoforms:  O95436-1   O95436-2   

Explore the universe of human proteins at neXtProt for SLC34A2: NX_O95436

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95436

    • SLC34A2 Protein expression data from MOPED and PaxDb:    About this image 
    SLC34A2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001171469.1  NP_001171470.1  NP_006415.2  

    ENSEMBL proteins: 
     ENSP00000423038   ENSP00000425501   ENSP00000371483   ENSP00000423021   ENSP00000424266  
    Reactome Protein details: O95436
    Human Recombinant Protein Products for SLC34A2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: SLC34A2
    OriGene Protein Over-expression Lysate: SLC34A2
    OriGene Custom Protein Services for SLC34A2 
    GenScript Custom Purified and Recombinant Proteins Services for SLC34A2
    Novus Biologicals SLC34A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC34A2

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane NAS10329428
    GO:0005903brush border ----
    GO:0016020membrane ----
    GO:0016021integral to membrane NAS10610722

    SLC34A2 for ontologies           About GeneDecksing



    SLC34A2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC34A2 
    GenScript Custom Superior Antibodies Services for SLC34A2
    Novus Biologicals SLC34A2 Antibody
    Search for Antibodies for SLC34A2 at Abcam  
    Uscn Antibodies for SLC34A2
    Search ThermoFisher Antibodies for SLC34A2

    Assay Products for SLC34A2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC34A2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for SLC34A2

    Protein Domains /
    Families
    for SLC34A2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC34A2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003841 Na/Pi_transpt

    Graphical View of Domain Structure for InterPro Entry O95436

    ProtoNet protein and cluster: O95436

    1 Blocks protein family: IPB003841 Na+/Pi-cotransporter

    UniProtKB/Swiss-Prot: NPT2B_HUMAN, O95436
    Similarity: Belongs to the SLC34A transporter family


    Function
    for SLC34A2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NPT2B_HUMAN, O95436
    Function: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main
    phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in
    lungs' alveoli
    Biophysicochemical properties: pH dependence: Optimum pH is 6.6;
    Induction: Down-regulated by EGF

         Genatlas biochemistry entry for SLC34A2:
    solute carrier family 34 (sodium/phosphate cotransport) member A2, (brain)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005436sodium:phosphate symporter activity IDA12488042
    GO:0015321sodium-dependent phosphate transmembrane transporter activity IDA10329428
    GO:0031402sodium ion binding IDA12488042
    GO:0042301phosphate ion binding IDA12488042
         
    SLC34A2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC34A2:
     Decreased Hepatitis C virus re 

         8 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slc34a2):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  renal/urinary system  respiratory system 

    SLC34A2 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for SLC34A2: Slc34a2tm1Sega Slc34a2tm1Khan
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC34A2 

    miRNA
    Products:            		Browse 3'-UTR reporter clones for miRNA target validation
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC34A2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC34A2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-625* hsa-miR-381 hsa-let-7a-2* hsa-miR-410 hsa-miR-4287 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC34A2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC34A2 (see all 7)
    OriGene shRNA RFP: SLC34A2
    OriGene siRNA: SLC34A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC34A2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC34A2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for SLC34A2
    Sirion Biotech Customized adenovirus for overexpression of SLC34A2 
    Sirion Biotech Customized adenovirus for potent knockdown of SLC34A2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC34A2 (NM_006424)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC34A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC34A2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for SLC34A2
    Search LifeMap BioReagents cell lines for SLC34A2
    Sirion Biotech Customized stable knockdown cell line services for SLC34A2 
    Sirion Biotech Customized inducible knockdown cell line services for SLC34A2
    Sirion Biotech Customized stable overexpressing cell line services for SLC34A2
    Sirion Biotech Customized inducible overexpressing cell line services for SLC34A2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC34A2


    Pathways & Interactions
    for SLC34A2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Type II Na+/Pi cotransporters
    		Type II Na+/Pi cotransporters1.00
    		Sodium-coupled phosphate cotransporters0.60
    2SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transmembrane transport of small molecules0.50
    3Mineral absorption
    		Mineral absorption1.00
    4Amino acid and oligopeptide SLC transporters
    		Transport of inorganic cations/anions and amino acids/oligopeptides0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for SLC34A2
        Sodium-coupled phosphate cotransporters
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of inorganic cations/anions and amino acids/oligopeptides
    Type II Na+/Pi cotransporters


    1         Kegg Pathway  (Kegg details for SLC34A2):
        Mineral absorption


    SLC34A2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC34A2

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006811ion transport TAS--
    GO:0006817phosphate ion transport IDA10329428
    GO:0007568aging IEA--
    GO:0009750response to fructose stimulus IEA--

    SLC34A2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC34A2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC34A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC34A2

    2 HMDB Compounds for SLC34A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    PhosphateNFB Orthophosphate (see all 13)14265-44-2--
    1 Novoseek chemical compound relationship for SLC34A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    actinomycin d 42.3 1 11832333 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC34A2 / NPT2B 

    Transcripts
    for SLC34A2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC34A2 gene (3 alternative transcripts): 
    NM_001177998.1  NM_001177999.1  NM_006424.2  

    Unigene Cluster for SLC34A2:

    Solute carrier family 34 (sodium phosphate), member 2
    Hs.479372  [show with all ESTs]
    Unigene Representative Sequence: NM_001177999
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000513204 ENST00000504570 ENST00000382051(uc003grr.3 uc003grs.3 uc010iev.3)
    ENST00000503434 ENST00000507530 ENST00000510033

    miRNA
    Products:             		Browse 3'-UTR reporter clones for miRNA target validation
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC34A2
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC34A2 (see all 14):
    hsa-miR-300 hsa-miR-520d-5p hsa-miR-625* hsa-miR-381 hsa-let-7a-2* hsa-miR-410 hsa-miR-4287 hsa-miR-3150a-3p
    SwitchGear 3'UTR luciferase reporter plasmid: SLC34A2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC34A2 (see all 7)
    OriGene shRNA RFP: SLC34A2
    OriGene siRNA: SLC34A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC34A2
    Sirion Biotech Custom design and validation of potent shRNA sequences against SLC34A2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2 (see all 3)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): SLC34A2 (NM_006424)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC34A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC34A2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC34A2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC34A2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC34A2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC34A2

    Additional cDNA sequence: 

    AF111856.1 AF146796.1 AK075015.1 AK075045.1 AK075046.1 AK292675.1 AK314514.1 BC142704.1 
    BC146666.1 

    9 DOTS entries:

    DT.97801551  DT.446836  DT.100021521  DT.121238727  DT.97856100  DT.121238707  DT.92047417  DT.95371362 
    DT.121238716 

    24/115 AceView cDNA sequences (see all 115):

    AA477820 AA634679 AW102841 AA291423 CA435368 AI620114 AI701707 AI686272 
    BE745817 AI301537 BF037980 AI924355 AF111856 AA459527 AI537880 AA292224 
    AK075015 BE740044 AA434062 AI866635 BE315537 AI687687 CA435426 BE898287 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC34A2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:              -                                                                                 
    SP2:                                                                                                
    SP3:              -                                                                                 
    SP4:                                                                                                


    ECgene alternative splicing isoforms for SLC34A2

    Expression
    for SLC34A2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC34A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTGCCCCGC
    SLC34A2 Expression
    About this image

    SLC34A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Alveolar type II cells (Derivation of mature...)Lung
    Human kidney epithelial cell spheroids (Kidney spheroids for...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC34A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC34A2

    SOURCE GeneReport for Unigene cluster: Hs.479372

    UniProtKB/Swiss-Prot: NPT2B_HUMAN, O95436
    Tissue specificity: Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis,
    prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium

        SABiosciences Expression via Pathway-Focused PCR Array including SLC34A2: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC34A2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC34A2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC34A2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC34A2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC34A2

    Orthologs
    for SLC34A2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for SLC34A2 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC34A21 solute carrier family 34 (sodium phosphate), member more 65.24(n)
    65.08(a)    		   395131  NM_204474.1  NP_989805.1 
    lizard
    (Anolis carolinensis)    		 Reptilia SLC34A26
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343348.1(343574-368001)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.55962 Xenopus laevis transcribed sequence with weak similarity more 77.81(n)    BX847427.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii slc34a2b1 solute carrier family 34 (sodium phosphate), member more 65.88(n)
    65.99(a)    		   359838  NM_182877.1  NP_878297.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea ZK563.21 , 3 sodium-dependent phosphate transporter3
    Protein ZK563.21    		 40(a)3
    48.3(n)1
    38.16(a)1    		   X(3404257-3408365)3
    1913511  NM_076180.31  NP_508581.21 


    ENSEMBL Gene Tree for SLC34A2 (if available)
    TreeFam Gene Tree for SLC34A2 (if available) 

    Paralogs
    for SLC34A2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC34A2 gene
    SLC34A12  SLC34A32  
    3 SIMAP similar genes for SLC34A2 using alignment to 3 protein entries:     NPT2B_HUMAN (see all proteins):
    SLC34A2/ROS1 fusion    SLC34A1    SLC34A3

    SLC34A2 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC34A2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/554 NCBI SNPs in SLC34A2 are shown (see all 554)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 4 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1442397271,2
    		Cother25004355(+) TTTTTC/TGTGTG 6 F syn10--------
    rs562114331,2
    		C,F--24994074(+) AAATGA/GAAGCC 2 -- us2k14Minor allele frequency- G:0.11WA NA 242
    rs780143171,2
    		F--24994480(+) ACCCAA/GGCAGA 2 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1128837281,2
    		--24995180(+) GCATGG/AGGGTG 3 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs354194171,2
    		C,F,H--24995359(+) GACGGT/CCCCAG 3 -- us2k114Minor allele frequency- C:0.10NS NA WA 1804
    rs569267591,2
    		C,F--24996772(+) GCCTGC/ACACCG 3 -- int14Minor allele frequency- A:0.17WA NA 242
    rs285596211,2
    		--24997162(+) GAAAGA/GCGTGC 3 -- int10--------
    rs738074111,2
    		C--24998003(+) TAAGGG/AAAGCA 3 -- int12Minor allele frequency- A:0.06WA 120
    rs738074121,2
    		C--24998487(+) GATGGC/ACTTGA 3 -- int13Minor allele frequency- A:0.16WA NA 240
    rs286527311,2
    		--24998907(+) GGGGGC/TAGGAG 3 -- int11Minor allele frequency- T:0.00CSA 1

    HapMap Linkage Disequilibrium report for SLC34A2 (25656923 - 25680370 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC34A2: --
    Human Gene Mutation Database (HGMD): SLC34A2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC34A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC34A2

    Disorders / Diseases
    for SLC34A2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC34A2 for disorders           About GeneDecksing

    OMIM gene information: 604217   
    OMIM disorders: 265100  610441  
    UniProtKB/Swiss-Prot: NPT2B_HUMAN, O95436
  • Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM) [MIM:265100]. Pulmonary alveolar
    • microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs.
    Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to
    clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A
    'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal
    disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting
    in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with
    full penetrance
  • Note=A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG.
    • Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity

    9 diseases for SLC34A2:    About MalaCards
    pulmonary alveolar microlithiasis    testicular microlithiasis    monogenic disease    gout
    breast cancer    glioblastoma    pneumonia    prostatitis
    carcinoma

    1 disease from the University of Copenhagen DISEASES database for SLC34A2:
    Pulmonary alveolar microlithiasis
    Human Genome Epidemiology (HuGE) Navigator: SLC34A2 (1 document)

    Export disorders for SLC34A2 gene to outside databases

    Publications
    for SLC34A2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC34A2 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with SLC34A2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium- phosphate (Na+-Pi) transporter (SLC34A2). (PubMed id 10610722)1, 2, 3, 9 Xu H.... Ghishan F.K. (1999)
    2. Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. (PubMed id 10329428)1, 2, 3 Feild J.A.... Edwards R.M. (1999)
    3. Regulation of the human sodium-phosphate cotransporter NaPi-IIb gene promoter by epidermal growth factor. (PubMed id 11171583)1, 2, 9 Xu H.... Ghishan F.K. (2001)
    4. Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. (PubMed id 16960801)1, 2 Corut A.... Tolun A. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Regulation of intestinal NaPi-IIb cotransporter gene expression by estrogen. (PubMed id 12893629)1, 9 Xu H....Ghishan F.K. (2003)
    7. [A novel mutation of the SLC34A2 gene in a Chinese pe digree with pulmonary alveolar microlithiasis] (PubMed id 20017296)1, 9 Zhong Y.Q....Nie H.P. (2009)
    8. SLC34A2 gene mutation may explain comorbidity of pulmo nary alveolar microlithiasis and aortic valve sclerosis. (PubMed id 22336687)1 Jonsson A.L....Simonsen U. (2012)
    9. In silico analysis and immunohistochemical characteriz ation of NaPi2b protein expression in ovarian carcinoma with monoclonal antibody Mx35. (PubMed id 22553815)1 Soares I.C....Alves V.A. (2012)
    10. Immunohistochemical analysis of NaPi2b protein (MX35 a ntigen) expression and subcellular localization in human normal and cancer tissu es. (PubMed id 21956469)1 Kiyamova R....Filonenko V. (2011)

    External Searches for SLC34A2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing SLC34A2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10568 HGNC: 11020 AceView: SLC34A2 Ensembl:ENSG00000157765 euGenes: HUgn10568
    ECgene: SLC34A2 Kegg: 10568 H-InvDB: SLC34A2

    Other Databases showing SLC34A2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC34A2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC34A2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC34A2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC34A2 gene:
    Search GeneIP for patents involving SLC34A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for SLC34A2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for SLC34A2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC34A2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC34A2  
     OriGene Protein Over-expression Lysate for SLC34A2   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for SLC34A2   Browse 3'-UTR reporter clones for miRNA target validation  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC34A2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for SLC34A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC34A2   OriGene Custom Protein Services for SLC34A2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC34A2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC34A2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC34A2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC34A2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC34A2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC34A2
     GenScript Custom Purified and Recombinant Proteins Services for SLC34A2 GenScript cDNA clones with any tag delivered in your preferred vector for SLC34A2
     GenScript Custom Assay Services for SLC34A2 GenScript Custom Superior Antibodies Services for SLC34A2
     GenScript Custom overexpressing Cell Line Services for SLC34A2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC34A2 promoter
     Search Chromatin IP Primers for SLC34A2
     RT2 qPCR Primer Assay in human, mouse, rat SLC34A2
     GNC Network for SLC34A2
     SABiosciences PCR Arrays including human, mouse, rat SLC34A2
     Search Tocris compounds for SLC34A2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC34A2 antibodies
     SLC34A2 lysates
     Search for Antibodies for SLC34A2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for SLC34A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     SLC34A2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for SLC34A2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC34A2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC34A2
     SwitchGear Promoter luciferase reporter plasmids for SLC34A2
     Search ThermoFisher Antibodies for SLC34A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC34A2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC34A2
    Sirion Biotech Customized:
     stable knockdown cell line services for SLC34A2
     inducible knockdown cell line services for SLC34A2
     design and validation of potent shRNA sequences against SLC34A2
     adenovirus for potent knockdown of SLC34A2
     adenovirus for overexpression of SLC34A2
     stable overexpressing cell line services for SLC34A2
     inducible overexpressing cell line services for SLC34A2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      SLC34A2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4