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SLC32A1 Gene

protein-coding   GIFtS: 58
GCID: GC20P037353

Solute Carrier Family 32 (GABA Vesicular Transporter), Member...

(Previous name: vesicular inhibitory amino acid transporter)
(Previous symbol: VIAAT)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 32 (GABA Vesicular Transporter), Member 11 2     Vesicular GABA Transporter2 3
VIAAT1 2 3     VGAT2 3
Vesicular Inhibitory Amino Acid Transporter1 2     GABA And Glycine Transporter2 3
Solute Carrier Family 32 Member 12 3     hVIAAT2 3

External Ids:    HGNC: 110181   Entrez Gene: 1406792   Ensembl: ENSG000001014387   UniProtKB: Q9H5983   

Export aliases for SLC32A1 gene to outside databases

Previous GC identifers: GC00U990497 GC20P036787 GC20P034090


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC32A1 Gene:
The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and
glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family
II. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC32A1 Gene:
SLC32A1 (solute carrier family 32 (GABA vesicular transporter), member 1) is a protein-coding gene. Diseases associated with SLC32A1 include substance abuse, and nicotine addiction. GO annotations related to this gene include glycine transmembrane transporter activity and gamma-aminobutyric acid:hydrogen symporter activity.

UniProtKB/Swiss-Prot: VIAAT_HUMAN, Q9H598
Function: Involved in the uptake of GABA and glycine into the synaptic vesicles

Gene Wiki entry for SLC32A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC32A1 gene promoter:
         Pax-5   ATF-2   XBP-1   RelA   LCR-F1   GATA-1   CRE-BP1   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC32A1 promoter sequence
   Search Chromatin IP Primers for SLC32A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC32A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q11.23   Ensembl cytogenetic band:  20q11.23   HGNC cytogenetic band: 20q11

SLC32A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC32A1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P037353:  view genomic region     (about GC identifiers)

Start:
37,353,105 bp from pter      End:
37,358,015 bp from pter
Size:
4,911 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: VIAAT_HUMAN, Q9H598 (See protein sequence)
Recommended Name: Vesicular inhibitory amino acid transporter  
Size: 525 amino acids; 57415 Da
Sequence caution: Sequence=AAH36458.2; Type=Erroneous initiation;
Secondary accessions: Q8N489

Explore the universe of human proteins at neXtProt for SLC32A1: NX_Q9H598

Explore proteomics data for SLC32A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn341
  • Modification sites at PhosphoSitePlus

  • See SLC32A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_542119.1  
    ENSEMBL proteins: 
     ENSP00000217420  
    Reactome Protein details: Q9H598

    SLC32A1 Human Recombinant Protein Products:

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    SLC32A1 Antibody Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Vesicular inhibitory amino acid transporter
    SLC32 vesicular inhibitory amino acid transporter

    1 InterPro protein domain:
     IPR013057 AA_transpt_TM

    Graphical View of Domain Structure for InterPro Entry Q9H598

    ProtoNet protein and cluster: Q9H598

    UniProtKB/Swiss-Prot: VIAAT_HUMAN, Q9H598
    Similarity: Belongs to the amino acid/polyamine transporter 2 family


    SLC32A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: VIAAT_HUMAN, Q9H598
    Function: Involved in the uptake of GABA and glycine into the synaptic vesicles

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015187glycine transmembrane transporter activity IEA--
    GO:0015495gamma-aminobutyric acid:hydrogen symporter activity IEA--
         
    SLC32A1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC32A1:
     Increased circadian period len 

         12 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Slc32a1):
     adipose tissue  behavior/neurological  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  respiratory system 

    SLC32A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC32A1: Slc32a1tm1Rhee Slc32a1tm1Yyan

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC32A1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC32A1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC32A1

    miRNA
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    miRTarBase miRNAs that target SLC32A1:
    hsa-mir-148b-3p (MIRT019437)

    Block miRNA regulation of human, mouse, rat SLC32A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC32A1 (see all 20):
    hsa-miR-100* hsa-miR-875-3p hsa-miR-25 hsa-miR-944 hsa-miR-518e hsa-miR-197 hsa-miR-3692 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidSLC32A1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC32A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    VIAAT_HUMAN, Q9H598: Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0008021synaptic vesicle ----
    GO:0016021integral component of membrane IEA--
    GO:0030425dendrite IDA12115694
    GO:0030672synaptic vesicle membrane TAS--

    SLC32A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC32A1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Synaptic vesicle cycle
    Synaptic Vesicle Pathway0.50
    Synaptic vesicle cycle0.50
    2Circadian entrainment
    GABAergic synapse0.53
    Retrograde endocannabinoid signaling0.51
    Morphine addiction0.53
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of inorganic cations/anions and amino acids/oligopeptides0.38
    Transmembrane transport of small molecules0.47
    4Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neuronal System0.68
    5Neurotransmitter Release Cycle
    Neurotransmitter Release Cycle0.32
    GABA synthesis, release, reuptake and degradation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for SLC32A1
        Synaptic Vesicle Pathway

    2 Reactome Pathways for SLC32A1
        GABA synthesis, release, reuptake and degradation
    Transport of inorganic cations/anions and amino acids/oligopeptides

    1 PharmGKB Pathway for SLC32A1
        Benzodiazepine Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for SLC32A1):
        Synaptic vesicle cycle
    Retrograde endocannabinoid signaling
    GABAergic synapse
    Morphine addiction
    Nicotine addiction


    SLC32A1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC32A1: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC32A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for SLC32A1 (ENSP000002174204) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPLX1ENSP000003056134STRING: ENSP00000305613
    DNAJC5ENSP000003541114STRING: ENSP00000354111
    HSPA8ENSP000002273784STRING: ENSP00000227378
    RAB3AENSP000002222564STRING: ENSP00000222256
    RIMS1ENSP000002648394STRING: ENSP00000264839
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport TAS--
    GO:0007268synaptic transmission TAS--
    GO:0007269neurotransmitter secretion TAS--
    GO:0007568aging IEA--
    GO:0015816glycine transport ----

    SLC32A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC32A1 (VIAAT)

    1 DrugBank Compound for SLC32A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Glycine2-Aminoacetic acid (see all 4)56-40-6target--17554001 17652600 17418495

    1 IUPHAR Ligand for SLC32A1 (Vesicular inhibitory amino acid transporter)    About this table
    LigandTypeActionAffinityPubmed IDs
    vigabatrin
    InhibitorInhibition2.19349821

    8 Novoseek inferred chemical compound relationships for SLC32A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gaba 81.8 127 19843525 (5), 12531468 (3), 17218060 (3), 16146821 (3) (see all 41)
    glutamate 66.7 21 16572456 (2), 20053882 (1), 12834881 (1), 18041776 (1) (see all 16)
    baclofen 44 4 12850545 (2)
    acetylcholine 28.5 5 16572456 (2), 10864948 (1), 20141423 (1), 12750892 (1)
    dopamine 2.46 2 14631117 (1), 17218060 (1)
    atp 0 2 19428801 (1)
    calcium 0 1 15745703 (1)
    nmda 0 2 11198298 (1)



    SLC32A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC32A1 gene: 
    NM_080552.2  

    Unigene Cluster for SLC32A1:

    Solute carrier family 32 (GABA vesicular transporter), member 1
    Hs.179080  [show with all ESTs]
    Unigene Representative Sequence: NM_080552
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000217420(uc002xjc.3)
    miRNA
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    Additional mRNA sequence: 

    AF064848.1 AK055051.1 AK091079.1 AY044836.1 BC036458.2 BC053582.1 

    2 DOTS entries:

    DT.70104443  DT.120831826 

    Selected AceView cDNA sequences (see all 25):

    NM_080552 AI937094 AY044836 BI822066 AK091079 BC053582 CD557601 AI918128 
    AK055051 AI571261 BP347882 BM717642 BM727848 BG700073 CD635842 BM717437 
    BI488536 BM674800 BC036458 BU741525 BP360909 AF064848 BU739204 H23502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC32A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCTCACCG
    SLC32A1 Expression
    About this image


    SLC32A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Endothelial Cells Blood Brain Barrier
             Midbrain tegmentum
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             Cardiac Crescent Cells Cardiac Crescent
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Metanephros
    SLC32A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC32A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179080

    UniProtKB/Swiss-Prot: VIAAT_HUMAN, Q9H598
    Tissue specificity: Retina. Expressed throughout the horizontal cells or more specifically at the terminals

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC32A1: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC32A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC32A1 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc32a11 , 5 solute carrier family 32 (GABA vesicular transporter), more1, 5 91.92(n)1
    98.85(a)1
      2 (78.72 cM)5
    223481  NM_009508.21  NP_033534.21 
     1586107675 
    chicken
    (Gallus gallus)
    Aves SLC32A11 solute carrier family 32 (GABA vesicular transporter), more 80.23(n)
    92.71(a)
      419167  XM_417347.3  XP_417347.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC32A16
    solute carrier family 32 (GABA vesicular transport...
    91(a)
    1 ↔ 1
    4(141334219-141340912)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689382 hypothetical protein MGC68938 79.04(n)    BC057733.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc32a11 solute carrier family 32 (GABA vesicular transporter), more 81.26(n)
    87.38(a)
      798575  NM_001080701.1  NP_001074170.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta VGAT1 Vesicular GABA Transporter 58.06(n)
    49.88(a)
      36574  NM_137094.2  NP_610938.1 
    worm
    (Caenorhabditis elegans)
    Secernentea unc-471 unc-47 48.65(n)
    43.15(a)
      176431  NM_066854.5  NP_499255.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AVT1(YJR001W)4 Vacuolar transporter, imports large neutral amino acids more   --   10(436802-438610) 853457  NP_012534.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G411901 AT2G41190 37.62(n)
    25.74(a)
      818718  NM_129684.2  NP_030664.1 


    ENSEMBL Gene Tree for SLC32A1 (if available)
    TreeFam Gene Tree for SLC32A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC32A1 (see all 149)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1825003481,2
    --37351233(+) TTTGTA/TTTGTT 1 -- us2k10--------
    rs1460113841,2
    --37351235(+) TGTTTC/TGTTTT 1 -- us2k10--------
    rs1398431811,2
    --37351326(+) GGCAGA/GAGCTA 1 -- us2k10--------
    rs1471184581,2
    --37351701(+) GCCCC-/CACTT 
     CCAGTCA
    CAGCC
    1 -- us2k10--------
    rs1415947931,2
    --37351702(+) CCCCC-/ACT   
      TCCAGT
    CACAG
    1 -- us2k10--------
    rs3707951241,2
    C--37351702(+) CCCCC-/ACTT  
     CCAGTCA
    CAGCC
    1 -- us2k10--------
    rs28673261,2
    C--37351706(+) CACTTC/ACAGTC 1 -- us2k1 tfbs34Minor allele frequency- A:0.16NA WA 242
    rs1880123241,2
    --37351957(+) AACCAA/CACAGA 1 -- us2k10--------
    rs1432705241,2
    --37352075(+) TCGCGC/GTCACA 1 -- us2k10--------
    rs81187901,2
    C,F,A,H--37352112(+) GCCCAA/GGCTTT 1 -- us2k118Minor allele frequency- G:0.12NS EA NA CSA WA 2319

    HapMap Linkage Disequilibrium report for SLC32A1 (37353105 - 37358015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for SLC32A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4568n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC32A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC32A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    9 diseases for SLC32A1:    
    About MalaCards
    substance abuse    nicotine addiction    schizophrenia    malaria
    adenoma    neuronitis    cerebritis    pancreatitis
    endotheliitis


    SLC32A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC32A1
    Human Genome Epidemiology (HuGE) Navigator: SLC32A1 (3 documents)

    Export disorders for SLC32A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC32A1 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with SLC32A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Vesicular inhibitory amino acid transporter is a Cl-/gamma-aminobutyrate Co-transporter. (PubMed id 19843525)1, 3, 9 Juge N....Moriyama Y. (J. Biol. Chem. 2009)
    2. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Cellular localization of the vesicular inhibitory amino acid transporter in the mouse and human retina. (PubMed id 12115694)1, 2 Jellali A.... Picaud S. (J. Comp. Neurol. 2002)
    6. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    7. The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids. (PubMed id 12750892)1, 9 Gasnier B. (Pflugers Arch. 2004)
    8. Evidence for a GABAergic system in rodent and human testis: local GABA production and GABA receptors. (PubMed id 12806177)1, 9 Geigerseder C....Mayerhofer A. (Neuroendocrinology 2003)
    9. Glutamatergic and GABAergic innervation of human gonadotropin-releasing hormone-I neurons. (PubMed id 22510271)1 Hrabovszky E....Liposits Z. (Endocrinology 2012)
    10. Expression of VGluT1 and VGAT mRNAs in human dorsolateral prefrontal cortex during development and in schizophrenia. (PubMed id 21396926)1 Fung S.J....Weicker C.S. (Brain Res. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140679 HGNC: 11018 AceView: VIAAT Ensembl:ENSG00000101438 euGenes: HUgn140679
    ECgene: SLC32A1 Kegg: 140679 H-InvDB: SLC32A1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC32A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC32A1 gene:
    Search GeneIP for patents involving SLC32A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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