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Aliases for SLC32A1 Gene

Aliases for SLC32A1 Gene

  • Solute Carrier Family 32 Member 1 2 3 4 5
  • Solute Carrier Family 32 (GABA Vesicular Transporter), Member 1 2 3
  • Vesicular Inhibitory Amino Acid Transporter 2 3
  • GABA And Glycine Transporter 3 4
  • Vesicular GABA Transporter 3 4
  • HVIAAT 3 4
  • VIAAT 3 4
  • VGAT 3 4

External Ids for SLC32A1 Gene

Previous HGNC Symbols for SLC32A1 Gene

  • VIAAT

Previous GeneCards Identifiers for SLC32A1 Gene

  • GC00U990497
  • GC20P036787
  • GC20P037353
  • GC20P034090

Summaries for SLC32A1 Gene

Entrez Gene Summary for SLC32A1 Gene

  • The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC32A1 Gene

SLC32A1 (Solute Carrier Family 32 Member 1) is a Protein Coding gene. Among its related pathways are GABAergic synapse and Neurotransmitter Release Cycle. GO annotations related to this gene include amino acid transmembrane transporter activity and gamma-aminobutyric acid:proton symporter activity.

UniProtKB/Swiss-Prot for SLC32A1 Gene

  • Involved in the uptake of GABA and glycine into the synaptic vesicles.

Gene Wiki entry for SLC32A1 Gene

Additional gene information for SLC32A1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC32A1 Gene

Genomics for SLC32A1 Gene

Regulatory Elements for SLC32A1 Gene

Enhancers for SLC32A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H038722 0.7 FANTOM5 10.8 -1.5 -1491 0 MAZ MXI1 HINFP SUZ12 ZSCAN4 GLIS2 POLR2A GLIS1 ZNF600 SP7 SLC32A1 GC20P038725 ENSG00000277965
GH20H039049 1.6 FANTOM5 Ensembl ENCODE 3.2 +325.6 325641 1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 DEK DHX35 ACTR5 RALGAPB SLC32A1 PPP1R16B PIR38411 NPM1P19
GH20H038870 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +149.4 149354 7 HDAC1 HDGF PKNOX1 TBL1XR1 BMI1 BATF RAD21 RFX5 TCF12 GATA2 PPP1R16B FAM83D ACTR5 SLC32A1 DHX35 RALGAPB RN7SL116P GC20M038907
GH20H038673 1.5 FANTOM5 Ensembl ENCODE 1.5 -50.1 -50142 1 HDAC1 TBP PKNOX1 ATF1 RB1 KLF17 ZNF766 GLIS2 EGR1 ATF7 ARHGAP40 KIAA1755 ACTR5 SLC32A1 PIR44827 GC20M038618
GH20H038651 0.5 FANTOM5 3.8 -72.4 -72373 0 TCF12 CREB1 SLC32A1 GC20M038618 PIR44827
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC32A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC32A1 Gene

Chromosome:
20
Start:
38,724,462 bp from pter
End:
38,729,372 bp from pter
Size:
4,911 bases
Orientation:
Plus strand

Genomic View for SLC32A1 Gene

Genes around SLC32A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC32A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC32A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC32A1 Gene

Proteins for SLC32A1 Gene

  • Protein details for SLC32A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H598-VIAAT_HUMAN
    Recommended name:
    Vesicular inhibitory amino acid transporter
    Protein Accession:
    Q9H598
    Secondary Accessions:
    • Q8N489

    Protein attributes for SLC32A1 Gene

    Size:
    525 amino acids
    Molecular mass:
    57415 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36458.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for SLC32A1 Gene

Post-translational modifications for SLC32A1 Gene

  • Glycosylation at Asn341
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC32A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC32A1 Gene

Domains & Families for SLC32A1 Gene

Gene Families for SLC32A1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC32A1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC32A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H598

UniProtKB/Swiss-Prot:

VIAAT_HUMAN :
  • Belongs to the amino acid/polyamine transporter 2 family.
Family:
  • Belongs to the amino acid/polyamine transporter 2 family.
genes like me logo Genes that share domains with SLC32A1: view

Function for SLC32A1 Gene

Molecular function for SLC32A1 Gene

UniProtKB/Swiss-Prot Function:
Involved in the uptake of GABA and glycine into the synaptic vesicles.

Phenotypes From GWAS Catalog for SLC32A1 Gene

Gene Ontology (GO) - Molecular Function for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005276 vesicular hydrogen:amino acid antiporter activity TAS --
GO:0015171 amino acid transmembrane transporter activity TAS --
GO:0015187 glycine transmembrane transporter activity IEA --
GO:0015495 gamma-aminobutyric acid:proton symporter activity IEA --
genes like me logo Genes that share ontologies with SLC32A1: view
genes like me logo Genes that share phenotypes with SLC32A1: view

Animal Models for SLC32A1 Gene

MGI Knock Outs for SLC32A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC32A1

CRISPR Products

miRNA for SLC32A1 Gene

miRTarBase miRNAs that target SLC32A1

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC32A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC32A1 Gene

Localization for SLC32A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC32A1 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC32A1 gene
Compartment Confidence
plasma membrane 5
nucleus 2
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030285 integral component of synaptic vesicle membrane IEA --
genes like me logo Genes that share ontologies with SLC32A1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC32A1 Gene

Pathways & Interactions for SLC32A1 Gene

genes like me logo Genes that share pathways with SLC32A1: view

Gene Ontology (GO) - Biological Process for SLC32A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport IEA --
GO:0006811 ion transport TAS --
GO:0006836 neurotransmitter transport IEA --
GO:0007269 neurotransmitter secretion TAS --
genes like me logo Genes that share ontologies with SLC32A1: view

No data available for SIGNOR curated interactions for SLC32A1 Gene

Drugs & Compounds for SLC32A1 Gene

(8) Drugs for SLC32A1 Gene - From: DrugBank, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved, Vet_approved Nutra Full agonist, Agonist, Target 243
Vigabatrin Approved Pharma Inhibition, Inhibitor, inhibitor GABA transaminase inhibitor, GABA-T inhibitor 21

(2) Additional Compounds for SLC32A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC32A1: view

Transcripts for SLC32A1 Gene

mRNA/cDNA for SLC32A1 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(25) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC32A1 Gene

Solute carrier family 32 (GABA vesicular transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC32A1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC32A1 Gene

No ASD Table

Relevant External Links for SLC32A1 Gene

GeneLoc Exon Structure for
SLC32A1
ECgene alternative splicing isoforms for
SLC32A1

Expression for SLC32A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC32A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC32A1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x12.3), Brain - Putamen (basal ganglia) (x8.8), Brain - Caudate (basal ganglia) (x6.9), and Brain - Hypothalamus (x4.3).

Protein differential expression in normal tissues from HIPED for SLC32A1 Gene

This gene is overexpressed in Fetal Brain (35.2), Frontal cortex (16.1), and Retina (15.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC32A1 Gene



Protein tissue co-expression partners for SLC32A1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC32A1 Gene:

SLC32A1

SOURCE GeneReport for Unigene cluster for SLC32A1 Gene:

Hs.179080

mRNA Expression by UniProt/SwissProt for SLC32A1 Gene:

Q9H598-VIAAT_HUMAN
Tissue specificity: Retina. Expressed throughout the horizontal cells or more specifically at the terminals.

Evidence on tissue expression from TISSUES for SLC32A1 Gene

  • Nervous system(4.8)
  • Eye(2)
genes like me logo Genes that share expression patterns with SLC32A1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC32A1 Gene

Orthologs for SLC32A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC32A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC32A1 33 34
  • 99.43 (n)
dog
(Canis familiaris)
Mammalia SLC32A1 33 34
  • 93.59 (n)
cow
(Bos Taurus)
Mammalia SLC32A1 33 34
  • 93.46 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC32A1 34
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc32a1 33
  • 92.18 (n)
mouse
(Mus musculus)
Mammalia Slc32a1 33 16 34
  • 91.92 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC32A1 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC32A1 33 34
  • 80.23 (n)
lizard
(Anolis carolinensis)
Reptilia SLC32A1 34
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc32a1 33
  • 75.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68938 33
zebrafish
(Danio rerio)
Actinopterygii slc32a1 33 34
  • 81.26 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011116 33
  • 61.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta VGAT 33 34
  • 58.06 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-47 33 34
  • 48.65 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AVT1 34 36
  • 17 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G41190 33
  • 37.62 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for SLC32A1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC32A1 Gene

ENSEMBL:
Gene Tree for SLC32A1 (if available)
TreeFam:
Gene Tree for SLC32A1 (if available)

Paralogs for SLC32A1 Gene

No data available for Paralogs for SLC32A1 Gene

Variants for SLC32A1 Gene

Sequence variations from dbSNP and Humsavar for SLC32A1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000849821 -- 38,724,122(+) AGCTT(A/G)GCACC upstream-variant-2KB
rs1000923399 -- 38,723,814(+) TGAGG(C/G)TGAGC upstream-variant-2KB
rs1001007774 -- 38,724,384(+) CGGGT(-/G)GGGGC upstream-variant-2KB
rs1001097482 -- 38,724,102(+) GTGGG(A/G)AGGGC upstream-variant-2KB
rs1001149766 -- 38,723,908(+) GGAAA(C/G)TGACT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC32A1 Gene

Variant ID Type Subtype PubMed ID
nsv1058457 CNV loss 25217958
nsv954035 CNV deletion 24416366

Variation tolerance for SLC32A1 Gene

Residual Variation Intolerance Score: 20.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC32A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC32A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC32A1 Gene

Disorders for SLC32A1 Gene

Relevant External Links for SLC32A1

Genetic Association Database (GAD)
SLC32A1
Human Genome Epidemiology (HuGE) Navigator
SLC32A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC32A1

No disorders were found for SLC32A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC32A1 Gene

Publications for SLC32A1 Gene

  1. Vesicular inhibitory amino acid transporter is a Cl-/gamma-aminobutyrate Co-transporter. (PMID: 19843525) Juge N … Moriyama Y (The Journal of biological chemistry 2009) 2 3 22 60
  2. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 45 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids. (PMID: 12750892) Gasnier B (Pflugers Archiv : European journal of physiology 2004) 3 22 60

Products for SLC32A1 Gene

Sources for SLC32A1 Gene

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