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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC31A2 Gene

protein-coding   GIFtS: 56
GCID: GC09P115913

solute carrier family 31 (copper transporters), member 2


(Previous symbol: COPT2)
 Explore 2 diseases affiliated with
SLC31A2 via our new
 Human Malady Compendium 
Biological research products
for SLC31A2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 31 (Copper Transporters), Member 21 2     Copper Transporter 22 3
COPT21 2 3 5     Solute Carrier Family 31 Member 22 3
CTR21 2 3 5     Probable Low Affinity Copper Uptake Protein 22
HCTR21     SLC13A25

External Ids:    HGNC: 110171   Entrez Gene: 13182   Ensembl: ENSG000001368677   OMIM: 6030885   UniProtKB: O154323   
ORGUL members:         
NONCODE:n335555 n341759    

Export aliases for SLC31A2 gene to outside databases

Previous GC identifers: GC09P106711 GC09P107645 GC09P109366 GC09P111289 GC09P112992 GC09P114953 GC09P085521


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: COPT2_HUMAN, O15432
Function: Involved in low-affinity copper uptake (Potential)

Gene Wiki entry for SLC31A2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC31A2 gene promoter:
         RP58   AML1a   Olf-1   NF-kappaB   CREB   PPAR-gamma1   deltaCREB   MRF-2   NF-kappaB1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC31A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC31A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC31A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

SLC31A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC31A2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P115913:  view genomic region     (about GC identifiers)

Start:
115,913,222 bp from pter      End:
115,926,422 bp from pter
Size:
13,201 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

  • n341759
  • n335555
115913264 115919841 115926417 chr9

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COPT2_HUMAN, O15432 (See protein sequence)
Recommended Name: Probable low affinity copper uptake protein 2  
Size: 143 amino acids; 15681 Da
Subcellular location: Membrane; Multi-pass membrane protein (Probable)

Explore the universe of human proteins at neXtProt for SLC31A2: NX_O15432

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15432

  • SLC31A2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001851.1  
    ENSEMBL proteins: 
     ENSP00000259392   ENSP00000363337  

    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC31A2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS9207117


    SLC31A2 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC31A2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR007274 Cop_transporter

    Graphical View of Domain Structure for InterPro Entry O15432

    ProtoNet protein and cluster: O15432

    1 Blocks protein family: IPB007274 Ctr copper transporter

    UniProtKB/Swiss-Prot: COPT2_HUMAN, O15432
    Similarity: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: COPT2_HUMAN, O15432
    Function: Involved in low-affinity copper uptake (Potential)

         Genatlas biochemistry entry for SLC31A2:
    solute carrier family 31,copper uptake transport,low affinity,homolog to yeast ctr2,with an alternatively spliced form
    CTR2X,ubiquitously expressed

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    hsa-miR-3910 hsa-let-7d hsa-let-7c hsa-miR-449a hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-let-7a
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005375copper ion transmembrane transporter activity IEA--


    SLC31A2 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for SLC31A2:
     Increased cilium length after   Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC31A2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC31A2 (O154322, 3 ENSP000002593924) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAMP2O608953, ENSP000002537964I2D: score=1 STRING: ENSP00000253796
    RAMP1O608943, ENSP000002546614I2D: score=1 STRING: ENSP00000254661
    RAMP3O608963, ENSP000002422494I2D: score=1 STRING: ENSP00000242249
    --Q9WMX22MINT-7047095
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006825copper ion transport TAS9207117
    GO:0035434copper ion transmembrane transport ----


    SLC31A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC31A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC31A2

    1 HMDB Compound for SLC31A2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    2 DrugBank Compounds for SLC31A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CarboplatinCBDCA (see all 2)41575-94-4transportersubstrate19509135
    CisplatinCis-DDP (see all 4)15663-27-1transportersubstrate19509135

    1 Novoseek chemical compound relationship for SLC31A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 63.3 24 17617060 (5), 19509135 (2), 20194531 (1), 11054564 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about SLC31A2 / COPT2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC31A2 gene: 
    NM_001860.2  

    Unigene Cluster for SLC31A2:

    Solute carrier family 31 (copper transporters), member 2
    Hs.24030  [show with all ESTs]
    Unigene Representative Sequence: AK131071
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259392(uc011lxb.2 uc004bgq.3) ENST00000490809 ENST00000374220


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    hsa-miR-3910 hsa-let-7d hsa-let-7c hsa-miR-449a hsa-let-7g hsa-miR-9 hsa-miR-124 hsa-let-7a
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    Additional cDNA sequence: 

    AK057903.1 AK131071.1 AK295544.1 BC026252.1 CR407615.1 U83461.1 

    11 DOTS entries:

    DT.415604  DT.100830727  DT.100718199  DT.91732872  DT.95119320  DT.100789283  DT.121207562  DT.121207565 
    DT.91755272  DT.95192679  DT.409020 

    24/202 AceView cDNA sequences (see all 202):

    CR623857 CK429346 CR407615 BP355947 BI488906 CR609395 CR594089 BM920294 
    AW572808 CR620050 CK430917 CD358158 BM919547 AW029537 CR597160 CR613559 
    CR597706 CR621630 CR622921 CR593518 BI764916 CR626490 AI460229 BI771145 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
    SP1:                          -     -                 -                 -                                 
    SP2:                          -     -                 -     -           -                                 
    SP3:                          -     -           -     -     -           -                                 
    SP4:                          -     -           -     -     -           -     -     -     -               
    SP5:                                            -     -     -           -                                 


    ECgene alternative splicing isoforms for SLC31A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC31A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGTACTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC31A2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeOuter Nuclear LayerMature Rod CellsPhotoreceptors, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

    See SLC31A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC31A2

    SOURCE GeneReport for Unigene cluster: Hs.24030

    UniProtKB/Swiss-Prot: COPT2_HUMAN, O15432
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC31A2 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC31A21 solute carrier family 31 (copper transporters), member more 64.52(n)
    60.71(a)
      425778  XM_423492.3  XP_423492.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc31a21 solute carrier family 31 (copper transporters), member more 56.13(n)
    50(a)
      563012  NM_001198749.1  NP_001185678.1 
    honey bee
    (Apis mellifera)
    Insecta --
    --
    --
    30(a)
    17(a)
    possible ortholog
    possible ortholog
    GroupUn.6298(22366-23355)
    Group3.25(129086-130208)
    worm
    (Caenorhabditis elegans)
    Secernentea F31E8.46
    F27C1.26
    (see all 3)
    Protein F27C1.2, isoform a
    (see all 3)
    25(a)
    16(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    II(6799076-6800101)
    I(5430165-5431489)


    ENSEMBL Gene Tree for SLC31A2 (if available)
    TreeFam Gene Tree for SLC31A2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC31A2 gene
    SLC31A12  

    SLC31A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/250 NCBI SNPs in SLC31A2 are shown (see all 250    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs39236021,2
    C,F,A,H,--115911257(-) GTCATT/CTCTCC 1 -- us2k1 trp322Minor allele frequency- C:0.11NS EA NA CSA WA 2480
    rs39236011,2
    C,F,A,H,--115911276(-) TAGAGC/TGGAAA 1 -- us2k123Minor allele frequency- T:0.09NS EA NA WA 2768
    rs1501943821,2
    --115911540(+) TGCAAC/TAAGCT 1 -- us2k10--------
    rs1134665781,2
    --115911685(+) AGCCAG/ACAAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1123218211,2
    --115911736(+) CAGGTG/TGGGGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1493816541,2
    --115911737(+) AGGTGC/GGGGGA 1 -- us2k10--------
    rs1916174351,2
    --115911738(+) GGTGGC/GGGGAG 1 -- us2k10--------
    rs1124427501,2
    --115911745(+) GGAGTG/AGGGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs108174461,2
    C,F,A,H,--115911904(+) TCCCCA/CTGGCC 1 -- us2k117Minor allele frequency- C:0.08NS EA NA WA 2340
    rs1831298271,2
    --115912045(+) TGGCTC/TACGTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC31A2 (115913222 - 115926422 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for SLC31A2
         4 CNVs: 3779 31525 4652 0131

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SLC31A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC31A2 for disorders           About GeneDecksing

    OMIM gene information: 603088    OMIM disorders: --

    2 diseases for SLC31A2:    About MalaCards
    ovarian carcinoma    carcinoma


    Export disorders for SLC31A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC31A2 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with SLC31A2)
        Utopia: connect your pdf to the dynamic
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    1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PubMed id 9207117)1, 2, 3, 9 Zhou B. and Gitschier J. (1997)
    2. Copper transporter 2 regulates the cellular accumulat ion and cytotoxicity of Cisplatin and Carboplatin. (PubMed id 19509135)1, 7, 9 Blair B.G....Howell S.B. (2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. (PubMed id 17617060)1, 9 van den Berghe P.V....Klomp L.W. (2007)
    5. Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. (PubMed id 17944601)1, 9 Bertinato J....L'abbe M.R. (2008)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
    7. Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. (PubMed id 14722252)1 Kuwasako K....Eto T. (2004)
    8. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition. (PubMed id 11023820)9 Leuthauser K....Born W. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1318 HGNC: 11017 AceView: SLC31A2 Ensembl:ENSG00000136867 euGenes: HUgn1318
    ECgene: SLC31A2 H-InvDB: SLC31A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC31A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC31A2 gene:
    Search GeneIP for patents involving SLC31A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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