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Aliases for SLC31A2 Gene

Aliases for SLC31A2 Gene

  • Solute Carrier Family 31 (Copper Transporter), Member 2 2 3
  • Copper Transporter 2 2 3 4
  • COPT2 3 4 6
  • CTR2 3 4 6
  • Solute Carrier Family 31 Member 2 3 4
  • HCTR2 3 4
  • Solute Carrier Family 31 (Copper Transporters), Member 2 3
  • Probable Low Affinity Copper Uptake Protein 2 3
  • SLC13A2 6

External Ids for SLC31A2 Gene

Previous Symbols for SLC31A2 Gene

  • COPT2

Summaries for SLC31A2 Gene

GeneCards Summary for SLC31A2 Gene

SLC31A2 (Solute Carrier Family 31 (Copper Transporter), Member 2) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A1.

UniProtKB/Swiss-Prot for SLC31A2 Gene

  • Involved in low-affinity copper uptake.

Gene Wiki entry for SLC31A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC31A2 Gene

Genomics for SLC31A2 Gene

Genomic Location for SLC31A2 Gene

Start:
113,150,942 bp from pter
End:
113,164,142 bp from pter
Size:
13,201 bases
Orientation:
Plus strand

Genomic View for SLC31A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC31A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC31A2 Gene

Regulatory Elements for SLC31A2 Gene

Proteins for SLC31A2 Gene

  • Protein details for SLC31A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15432-COPT2_HUMAN
    Recommended name:
    Probable low affinity copper uptake protein 2
    Protein Accession:
    O15432
    Secondary Accessions:

    Protein attributes for SLC31A2 Gene

    Size:
    143 amino acids
    Molecular mass:
    15681 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC31A2 Gene

Proteomics data for SLC31A2 Gene at MOPED

Post-translational modifications for SLC31A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC31A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC31A2 Gene

Domains for SLC31A2 Gene

Gene Families for SLC31A2 Gene

Protein Domains for SLC31A2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

COPT2_HUMAN
Family:
  • Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.:
    • O15432
genes like me logo Genes that share domains with SLC31A2: view

Function for SLC31A2 Gene

Molecular function for SLC31A2 Gene

GENATLAS Biochemistry: solute carrier family 31,copper uptake transport,low affinity,homolog to yeast ctr2,with an alternatively spliced form CTR2X,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Involved in low-affinity copper uptake.

Gene Ontology (GO) - Molecular Function for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005375 copper ion transmembrane transporter activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with SLC31A2: view

Phenotypes for SLC31A2 Gene

genes like me logo Genes that share phenotypes with SLC31A2: view

miRNA for SLC31A2 Gene

miRTarBase miRNAs that target SLC31A2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC31A2 Gene

Localization for SLC31A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC31A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC31A2 Gene COMPARTMENTS Subcellular localization image for SLC31A2 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 1
cytosol 1
endosome 1
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
GO:0005887 integral component of plasma membrane TAS 9207117
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with SLC31A2: view

Pathways for SLC31A2 Gene

genes like me logo Genes that share pathways with SLC31A2: view

Gene Ontology (GO) - Biological Process for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006825 copper ion transport TAS 9207117
GO:0006878 cellular copper ion homeostasis IEA --
GO:0035434 copper ion transmembrane transport IEA --
GO:1902311 regulation of copper ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC31A2: view

Compounds for SLC31A2 Gene

(1) HMDB Compounds for SLC31A2 Gene

Compound Synonyms Cas Number PubMed IDs
Copper
  • Cu
7440-50-8

(2) Drugbank Compounds for SLC31A2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Carboplatin
  • CBDCA
41575-94-4 transporter substrate
Cisplatin
  • CDDP
15663-27-1 transporter substrate

(1) Novoseek inferred chemical compound relationships for SLC31A2 Gene

Compound -log(P) Hits PubMed IDs
copper 63.3 12
genes like me logo Genes that share compounds with SLC31A2: view

Transcripts for SLC31A2 Gene

Unigene Clusters for SLC31A2 Gene

Solute carrier family 31 (copper transporters), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP6:
SP7: - -
SP8: - - -

Relevant External Links for SLC31A2 Gene

GeneLoc Exon Structure for
SLC31A2
ECgene alternative splicing isoforms for
SLC31A2

Expression for SLC31A2 Gene

mRNA expression in normal human tissues for SLC31A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC31A2 Gene

This gene is overexpressed in Whole Blood (9.5) and Brain - Spinal cord (cervical c-1) (4.3).

SOURCE GeneReport for Unigene cluster for SLC31A2 Gene Hs.24030

mRNA Expression by UniProt/SwissProt for SLC31A2 Gene

O15432-COPT2_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with SLC31A2: view

Orthologs for SLC31A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC31A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC31A2 36
  • 99.06 (n)
  • 99.3 (a)
SLC31A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC31A2 36
  • 82.74 (n)
  • 78.01 (a)
SLC31A2 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC31A2 36
  • 83.33 (n)
  • 76.81 (a)
SLC31A2 37
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc31a2 36
  • 81.32 (n)
  • 78.01 (a)
Slc31a2 16
Slc31a2 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC31A2 37
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC31A2 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc31a2 36
  • 81.9 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves SLC31A2 36
  • 64.34 (n)
  • 60.84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc31a2 36
  • 57.21 (n)
  • 51.06 (a)
zebrafish
(Danio rerio)
Actinopterygii slc31a2 36
  • 57.11 (n)
  • 50.74 (a)
slc31a2 37
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ctr1A 37
  • 17 (a)
ManyToMany
Ctr1B 37
  • 20 (a)
ManyToMany
Ctr1C 37
  • 17 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 23 (a)
OneToOne
Species with no ortholog for SLC31A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC31A2 Gene

ENSEMBL:
Gene Tree for SLC31A2 (if available)
TreeFam:
Gene Tree for SLC31A2 (if available)

Paralogs for SLC31A2 Gene

Paralogs for SLC31A2 Gene

genes like me logo Genes that share paralogs with SLC31A2: view

Variants for SLC31A2 Gene

Sequence variations from dbSNP and Humsavar for SLC31A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2571 -- 113,164,037(-) TACAG(A/C)AGTGA utr-variant-3-prime
rs10603 -- 113,163,923(+) TGGCA(G/T)NTACT utr-variant-3-prime
rs12018 -- 113,163,923(+) GGCAN(G/T)TACTG utr-variant-3-prime
rs12982 -- 113,163,718(+) GAAGA(A/T)GATCT utr-variant-3-prime
rs1128771 -- 113,162,755(+) TGGTA(C/T)TTGTG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for SLC31A2 Gene

Variant ID Type Subtype PubMed ID
dgv2412e1 CNV Complex 17122850
nsv831691 CNV Loss 17160897
nsv483127 CNV Complex 15286789
dgv2416e1 CNV Complex 17122850
dgv8274n71 CNV Gain 21882294
nsv466507 CNV Loss 19166990
nsv8563 CNV Gain 18304495

Relevant External Links for SLC31A2 Gene

HapMap Linkage Disequilibrium report
SLC31A2

Disorders for SLC31A2 Gene

Relevant External Links for SLC31A2

Genetic Association Database (GAD)
SLC31A2
genes like me logo Genes that share disorders with SLC31A2: view

No data available for UniProtKB/Swiss-Prot for SLC31A2 Gene

Publications for SLC31A2 Gene

  1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PMID: 9207117) Zhou B. … Gitschier J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. (PMID: 19509135) Blair B.G. … Howell S.B. (Clin. Cancer Res. 2009) 3 23 25
  3. Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. (PMID: 17617060) van den Berghe P.V. … Klomp L.W. (Biochem. J. 2007) 3 23
  4. Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. (PMID: 17944601) Bertinato J. … L'abbAc M.R. (Biochem. J. 2008) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for SLC31A2 Gene

Sources for SLC31A2 Gene

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