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Aliases for SLC31A2 Gene

Aliases for SLC31A2 Gene

  • Solute Carrier Family 31 Member 2 2 3 4 5
  • Copper Transporter 2 2 3 4
  • Solute Carrier Family 31 (Copper Transporter), Member 2 2 3
  • COPT2 3 4
  • HCTR2 3 4
  • CTR2 3 4
  • Solute Carrier Family 31 (Copper Transporters), Member 2 3
  • Probable Low Affinity Copper Uptake Protein 2 3

External Ids for SLC31A2 Gene

Previous HGNC Symbols for SLC31A2 Gene

  • COPT2

Previous GeneCards Identifiers for SLC31A2 Gene

  • GC09P106711
  • GC09P107645
  • GC09P109366
  • GC09P111289
  • GC09P112992
  • GC09P114953
  • GC09P115913
  • GC09P085521

Summaries for SLC31A2 Gene

GeneCards Summary for SLC31A2 Gene

SLC31A2 (Solute Carrier Family 31 Member 2) is a Protein Coding gene. GO annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A1.

UniProtKB/Swiss-Prot for SLC31A2 Gene

  • Involved in low-affinity copper uptake.

Gene Wiki entry for SLC31A2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC31A2 Gene

Genomics for SLC31A2 Gene

Regulatory Elements for SLC31A2 Gene

Enhancers for SLC31A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F113125 0.3 FANTOM5 20.4 -25.3 -25286 0.3 STAT1 SLC31A2 SLC46A2 FAM225B SNX30 RGS3 PIR44474
GH09F113224 0.2 ENCODE 17.2 +73.3 73254 0.2 SOX13 SAP130 TEAD1 HLF CEBPB CEBPG ZBTB40 CEBPA FOS SLC31A2 CDC26 PRPF4 RNF183 SLC31A1 PIR39900
GH09F113129 0.4 FANTOM5 15.6 -20.8 -20837 0.2 JUND SLC31A2 RGS3 SNX30 PIR44474
GH09F113150 1 FANTOM5 ENCODE 15.5 +2.5 2543 6.2 ATF1 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF48 BRCA1 ETS1 ZNF121 SLC31A2 PRPF4 FKBP15 BSPRY LOC105376223 WDR31 SNX30 RGS3 SLC46A2 PIR43385
GH09F112860 1.4 FANTOM5 Ensembl ENCODE 13.7 -288.3 -288341 4.4 ZFP64 ZNF140 ZMYM3 MAX ZNF101 ZNF433 ZBTB11 CEBPB REST ZBTB8A SLC46A2 SNX30 ZFP37 ENSG00000226609 SLC31A2 PRPF4 RNF183 ENSG00000271631 FKBP15 PIR49803
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC31A2 on UCSC Golden Path with GeneCards custom track

Promoters for SLC31A2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001311989 458 2001 ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 ETS1 ZNF121 GLIS2 ZNF143

Genomic Location for SLC31A2 Gene

113,150,942 bp from pter
113,164,142 bp from pter
13,201 bases
Plus strand

Genomic View for SLC31A2 Gene

Genes around SLC31A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC31A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC31A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC31A2 Gene

Proteins for SLC31A2 Gene

  • Protein details for SLC31A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable low affinity copper uptake protein 2
    Protein Accession:

    Protein attributes for SLC31A2 Gene

    143 amino acids
    Molecular mass:
    15681 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC31A2 Gene

Post-translational modifications for SLC31A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC31A2 Gene

No data available for DME Specific Peptides for SLC31A2 Gene

Domains & Families for SLC31A2 Gene

Gene Families for SLC31A2 Gene

Protein Domains for SLC31A2 Gene


Suggested Antigen Peptide Sequences for SLC31A2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
  • Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.
genes like me logo Genes that share domains with SLC31A2: view

Function for SLC31A2 Gene

Molecular function for SLC31A2 Gene

GENATLAS Biochemistry:
solute carrier family 31,copper uptake transport,low affinity,homolog to yeast ctr2,with an alternatively spliced form CTR2X,ubiquitously expressed
UniProtKB/Swiss-Prot Function:
Involved in low-affinity copper uptake.

Gene Ontology (GO) - Molecular Function for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005375 copper ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC31A2: view
genes like me logo Genes that share phenotypes with SLC31A2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC31A2

miRNA for SLC31A2 Gene

miRTarBase miRNAs that target SLC31A2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC31A2 Gene

Localization for SLC31A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC31A2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC31A2 Gene COMPARTMENTS Subcellular localization image for SLC31A2 gene
Compartment Confidence
plasma membrane 5
endosome 3
cytoskeleton 2
cytosol 2
lysosome 2
nucleus 2
vacuole 2
extracellular 1

Gene Ontology (GO) - Cellular Components for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005770 late endosome IEA --
GO:0005887 integral component of plasma membrane TAS 9207117
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0055037 recycling endosome IEA --
genes like me logo Genes that share ontologies with SLC31A2: view

Pathways & Interactions for SLC31A2 Gene

SuperPathways for SLC31A2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC31A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006825 copper ion transport IEA,TAS 9207117
GO:0006878 cellular copper ion homeostasis IEA --
GO:0035434 copper ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC31A2: view

No data available for Pathways by source and SIGNOR curated interactions for SLC31A2 Gene

Drugs & Compounds for SLC31A2 Gene

(3) Drugs for SLC31A2 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carboplatin Approved Pharma Transporter, substrate Antitumor agent that forms platinum-DNA adducts., Platinum 1980
Cisplatin Approved Pharma Transporter, substrate Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Copper Approved Pharma 172
genes like me logo Genes that share compounds with SLC31A2: view

Transcripts for SLC31A2 Gene

Unigene Clusters for SLC31A2 Gene

Solute carrier family 31 (copper transporters), member 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - -
SP7: - -
SP8: - - -

Relevant External Links for SLC31A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC31A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC31A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC31A2 Gene

This gene is overexpressed in Whole Blood (x9.5) and Brain - Spinal cord (cervical c-1) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of SLC31A2 Gene:


SOURCE GeneReport for Unigene cluster for SLC31A2 Gene:


mRNA Expression by UniProt/SwissProt for SLC31A2 Gene:

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SLC31A2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for SLC31A2 Gene

Orthologs for SLC31A2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC31A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC31A2 34 35
  • 99.06 (n)
(Canis familiaris)
Mammalia SLC31A2 34 35
  • 83.33 (n)
(Bos Taurus)
Mammalia SLC31A2 34 35
  • 82.74 (n)
(Rattus norvegicus)
Mammalia Slc31a2 34
  • 81.9 (n)
(Mus musculus)
Mammalia Slc31a2 34 16 35
  • 81.32 (n)
(Ornithorhynchus anatinus)
Mammalia SLC31A2 35
  • 70 (a)
(Monodelphis domestica)
Mammalia SLC31A2 35
  • 64 (a)
(Gallus gallus)
Aves SLC31A2 34
  • 64.34 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc31a2 34
  • 57.21 (n)
(Danio rerio)
Actinopterygii slc31a2 34 35
  • 57.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ctr1B 35
  • 20 (a)
Ctr1A 35
  • 17 (a)
Ctr1C 35
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
Species where no ortholog for SLC31A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC31A2 Gene

Gene Tree for SLC31A2 (if available)
Gene Tree for SLC31A2 (if available)

Paralogs for SLC31A2 Gene

Paralogs for SLC31A2 Gene

genes like me logo Genes that share paralogs with SLC31A2: view

Variants for SLC31A2 Gene

Sequence variations from dbSNP and Humsavar for SLC31A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10121117 -- 113,156,026(+) CTGTC(A/G)TCTGC intron-variant, reference, missense
rs10121164 -- 113,156,272(+) AAGGA(A/G)GTCCG intron-variant
rs10121981 -- 113,157,150(+) ACTCA(C/T)CAAGG intron-variant
rs10122151 -- 113,157,605(+) TGATG(C/G)CCCTT intron-variant
rs10122895 -- 113,158,173(+) TCATT(G/T)TTCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC31A2 Gene

Variant ID Type Subtype PubMed ID
esv2759710 CNV gain 17122850
esv3621538 CNV loss 21293372
esv3891716 CNV loss 25118596
esv3891717 CNV loss 25118596
nsv1051654 CNV gain 25217958
nsv466507 CNV loss 19166990
nsv615212 CNV gain 21841781
nsv615213 CNV loss 21841781
nsv831691 CNV loss 17160897
nsv8563 CNV gain 18304495

Variation tolerance for SLC31A2 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC31A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC31A2 Gene

Disorders for SLC31A2 Gene

Relevant External Links for SLC31A2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC31A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC31A2 Gene

Publications for SLC31A2 Gene

  1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PMID: 9207117) Zhou B. … Gitschier J. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  2. Copper transporter 2 regulates the cellular accumulation and cytotoxicity of Cisplatin and Carboplatin. (PMID: 19509135) Blair B.G. … Howell S.B. (Clin. Cancer Res. 2009) 3 22 25 64
  3. Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells. (PMID: 17944601) Bertinato J. … L'abbAc M.R. (Biochem. J. 2008) 3 22 64
  4. Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake. (PMID: 17617060) van den Berghe P.V. … Klomp L.W. (Biochem. J. 2007) 3 22 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for SLC31A2 Gene

Sources for SLC31A2 Gene

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