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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC31A1 Gene

protein-coding   GIFtS: 59
GCID: GC09P115983

Solute Carrier Family 31 (Copper Transporter), Member 1


(Previous symbol: COPT1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 31 (Copper Transporter), Member 11 2     Copper Transport 1 Homolog (S. Cerevisiae)1
COPT11 2 3 5     Copper Transport 1 Homolog2
CTR12 3 5     High Affinity Copper Uptake Protein 12
Copper Transporter 12 3     Solute Carrier Family 31 (Copper Transporters), Member 12
Solute Carrier Family 31 Member 12 3     hCTR13

External Ids:    HGNC: 110161   Entrez Gene: 13172   Ensembl: ENSG000001368687   OMIM: 6030855   UniProtKB: O154313   

Export aliases for SLC31A1 gene to outside databases

Previous GC identifers: GC09P106782 GC09P107716 GC09P109437 GC09P111359 GC09P113063 GC09P115023 GC09P085591


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC31A1 Gene:
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded
protein functions as a homotrimer to effect the uptake of dietary copper. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC31A1 Gene: 
SLC31A1 (solute carrier family 31 (copper transporter), member 1) is a protein-coding gene. Diseases associated with SLC31A1 include ethylmalonic encephalopathy, and wilson disease, and among its related super-pathways are Transmembrane transport of small molecules and Zinc transporters. GO annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A2.

UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431
Function: High-affinity, saturable copper transporter involved in dietary copper uptake

Gene Wiki entry for SLC31A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.2  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC31A1 gene promoter:
         SRF   E2F-3a   E2F-4   E2F-5   SRF (504 AA)   E2F-2   C/EBPalpha   PPAR-alpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC31A1 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC31A1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC31A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

SLC31A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC31A1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P115983:  view genomic region     (about GC identifiers)

Start:
115,983,808 bp from pter      End:
116,028,674 bp from pter
Size:
44,867 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431 (See protein sequence)
Recommended Name: High affinity copper uptake protein 1  
Size: 190 amino acids; 21091 Da
Subunit: Homotrimer
Subcellular location: Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in
intestinal epithelial cells (By similarity)
3 PDB 3D structures from and Proteopedia for SLC31A1:
2LS2 (3D)        2LS3 (3D)        2LS4 (3D)    
Secondary accessions: A8K8Z6 Q53GR5 Q5T1M4

Explore the universe of human proteins at neXtProt for SLC31A1: NX_O15431

Explore proteomics data for SLC31A1 at MOPED 

Post-translational modifications:

  • UniProtKB: O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15431

  • SLC31A1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC31A1 Protein Expression
    REFSEQ proteins: NP_001850.1  
    ENSEMBL proteins: 
     ENSP00000363329   ENSP00000363327  
    Reactome Protein details: O15431
    Human Recombinant Protein Products for SLC31A1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9207117
    GO:0016021integral to membrane ----

    SLC31A1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Copper transporter 1 
    SLC31 family of copper transporters

    1 InterPro protein domain:
     IPR007274 Cop_transporter

    Graphical View of Domain Structure for InterPro Entry O15431

    ProtoNet protein and cluster: O15431

    1 Blocks protein domain: IPB007274 Ctr copper transporter

    UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431
    Similarity: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily


    SLC31A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPT1_HUMAN, O15431
    Function: High-affinity, saturable copper transporter involved in dietary copper uptake

         Genatlas biochemistry entry for SLC31A1:
    solute carrier family 31,copper uptake transport,high affinity,homolog to yeast ctr1,see D9S262,ubiquitously
    expressed

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005375copper ion transmembrane transporter activity IEA--
         
    SLC31A1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc31a1):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  other  pigmentation 

    SLC31A1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc31a1tm1Djt for SLC31A1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC31A1 
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    SwitchGear 3'UTR luciferase reporter plasmidSLC31A1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC31A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Zinc transporters
    Metal ion SLC transporters0.68
    3Mineral absorption
    Mineral absorption
    4Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for SLC31A1
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters

    1 PharmGKB Pathway for SLC31A1
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for SLC31A1):
        Mineral absorption


    SLC31A1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC31A1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for SLC31A1 (ENSP000003633294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UPF1ENSP000002628034STRING: ENSP00000262803
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006825copper ion transport TAS9207117
    GO:0035434copper ion transmembrane transport ----
    GO:0055085transmembrane transport TAS--

    SLC31A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC31A1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC31A1 (COPT1)

    1 HMDB Compound for SLC31A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    4 DrugBank Compounds for SLC31A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CisplatinCDDP (see all 7)15663-27-1transportersubstrate19529937 18998134 20159940 19075668 19570948 19144690 19147760 15229296
    CarboplatinCBDCA (see all 2)41575-94-4transportersubstrate15634647 20159940
    OxaliplatinDiaminocyclohexane Oxalatoplatinum (see all 4)61825-94-3transportersubstrate15634647 20159940
    Bortezomib-- 179324-69-7transporterinhibitor19147760

    6 Novoseek inferred chemical compound relationships for SLC31A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 82.5 211 14976198 (7), 15023397 (6), 12023893 (6), 12466020 (5) (see all 48)
    oxaliplatin 72.9 3 20159940 (1), 15229296 (1)
    cisplatin 71.6 85 15326162 (7), 19147760 (5), 20159940 (4), 15194000 (4) (see all 17)
    platinum 70.8 25 19147760 (2), 15326162 (1), 20159940 (1), 17097621 (1) (see all 7)
    carboplatin 63.8 3 20159940 (1), 15229296 (1)
    iron 38.7 3 18498772 (1), 9207117 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC31A1 / COPT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC31A1 gene: 
    NM_001859.3  

    Unigene Cluster for SLC31A1:

    Solute carrier family 31 (copper transporters), member 1
    Hs.532315  [show with all ESTs]
    Unigene Representative Sequence: NM_001859
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374212(uc004bgu.3) ENST00000496650 ENST00000374210(uc004bgv.4)

    miRNA
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    8/112 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC31A1 (see all 112):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-548j hsa-miR-607 hsa-miR-218-1* hsa-miR-938 hsa-miR-1260b hsa-miR-219-5p
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    Additional mRNA sequence: 

    AK056926.1 AK129613.1 AK222866.1 AK292511.1 AL831843.1 BC004315.1 BC013611.1 BC061924.1 
    BC131730.1 U83460.1 

    13 DOTS entries:

    DT.452552  DT.91736059  DT.97819356  DT.447359  DT.75102150  DT.92430731  DT.100686986  DT.100819981 
    DT.120871167  DT.121172973  DT.75191783  DT.95270371  DT.92058887 

    24/213 AceView cDNA sequences (see all 213):

    BX282604 AW272606 BM452908 AW960297 BQ718713 BC061924 BG696740 BM478744 
    BG421984 AA356345 CR605076 AK056926 BF942099 BM833714 AI039440 BU616476 
    BC004315 AA190729 N31448 BQ318894 CF126355 CB162262 BU630885 CB106649 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                    -                       -         
    SP2:                    -                                 
    SP3:                    -     -                 -         
    SP4:                                                      


    ECgene alternative splicing isoforms for SLC31A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC31A1 expression in normal human tissues (normalized intensities)      SLC31A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC31A1 Expression
    About this image


    SLC31A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
             brain/midbrain   
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
     
     Tooth (Integumentary System)    fully expand to see all 2 entries
             visceral organ/oral region/upper jaw   

    See SLC31A1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC31A1

    SOURCE GeneReport for Unigene cluster: Hs.532315
        SABiosciences Expression via Pathway-Focused PCR Array including SLC31A1: 
              Drug Transporters in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for SLC31A1 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc31a11 , 5 solute carrier family 31, member 11, 5 91.13(n)1
    93.09(a)1
      4 (33.11 cM)5
    205291  NM_175090.41  NP_780299.21 
     623607275 
    chicken
    (Gallus gallus)
    Aves SLC31A11 solute carrier family 31 (copper transporters), member more 77.47(n)
    84.62(a)
      417268  XM_415542.3  XP_415542.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC31A16
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL344086.1(38023-59022)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053785.12   -- 77.56(n)    BC053785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.68472 Danio rerio high affinity copper uptake protein (ctr-1) more 75.16(n)    AY077715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ctr1A1 Copper transporter 1A 56.4(n)
    50.58(a)
      31601  NM_132108.3  NP_572336.2 
    worm
    (Caenorhabditis elegans)
    Secernentea F27C1.21 Protein F27C1.2 47.74(n)
    38.06(a)
      172196  NM_001026248.2  NP_001021419.1 


    ENSEMBL Gene Tree for SLC31A1 (if available)
    TreeFam Gene Tree for SLC31A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC31A1 gene
    SLC31A22  

    SLC31A1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC31A1
    PGOHUM00000237863


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/686 SNPs in SLC31A1 are shown (see all 686)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485405111,2
    --115985876(+) AGTATA/GCAACT 1 -- int10--------
    rs1438956861,2
    --115985913(+) CAACCC/GCCAGA 1 -- int10--------
    rs1890031341,2
    --115986049(+) ATATAC/TGAGTA 1 -- int10--------
    rs1931452641,2
    --115986059(+) ATACCC/TATACT 1 -- int10--------
    rs1405360741,2
    --115986113(+) TATAAA/CCAAGT 1 -- int10--------
    rs778943161,2
    F--115986128(+) TCAGGC/TATAAT 1 -- int10--------
    rs1836420091,2
    --115986132(+) GCATAA/GTGATA 1 -- int10--------
    rs1512322801,2
    --115986261(+) ATACAA/GATAAT 1 -- int10--------
    rs1391779821,2
    --115986399(+) CACAGC/GCTTTC 1 -- int10--------
    rs109816941,2
    C,F,H--115986409(+) CTCATT/GTGTTT 1 -- int118Minor allele frequency- G:0.13NS EA NA 2252

    HapMap Linkage Disequilibrium report for SLC31A1 (115983808 - 116028674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC31A1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv893745CNV Loss21882294
    nsv893744CNV Gain21882294
    nsv893746CNV Gain21882294
    dgv2416e1CNV Complex17122850
    dgv2412e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): SLC31A1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC31A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC31A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603085    OMIM disorders: --

    17 diseases for SLC31A1:    About MalaCards
    ethylmalonic encephalopathy    wilson disease    menkes disease    t cell deficiency
    cleft lip    esophageal squamous cell carcinoma    choriocarcinoma    non-small cell lung carcinoma
    astrocytoma    esophagitis    prostate cancer    squamous cell carcinoma
    neuroblastoma    prostatitis    ovarian cancer    hypoxia
    lung cancer


    SLC31A1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SLC31A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilson disease 60.4 1 12023893 (1)
    ovarian carcinoma 51.4 7 15475465 (2), 19147760 (2), 20194531 (1), 15229296 (1)
    tumors 18.4 13 19470736 (4), 17015901 (1), 15229296 (1), 20159940 (1)
    ovarian cancer 3.94 3 19147760 (2), 20194531 (1), 20159940 (1)
    prostate cancer 0 2 17015901 (2)


    Export disorders for SLC31A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC31A1 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with SLC31A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PubMed id 9207117)1, 2, 3, 9 Zhou B. and Gitschier J. (1997)
    2. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. (PubMed id 19147760)1, 7, 9 Jandial D.D....Howell S.B. (2009)
    3. Protein kinase inhibitors emodin and dichloro-ribofur anosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisp latin in a schedule-dependent manner. (PubMed id 19529937)1, 7, 9 Kurokawa T....Siddik Z.H. (2010)
    4. The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. (PubMed id 19144690)1, 7 Pabla N....Dong Z. (2009)
    5. Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. (PubMed id 16501047)1, 2 Aller S.G. and Unger V.M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Biochemical characterization of the human copper transporter Ctr1. (PubMed id 11734551)1, 2 Lee J....Thiele D.J. (2002)
    9. Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1). (PubMed id 12023893)1, 9 Klomp A.E....Klomp L.W. (2002)
    10. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. (PubMed id 12466020)1, 9 Klomp A.E....Klomp L.W. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1317 HGNC: 11016 AceView: SLC31A1 Ensembl:ENSG00000136868 euGenes: HUgn1317
    ECgene: SLC31A1 Kegg: 1317 H-InvDB: SLC31A1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC31A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC31A1 gene:
    Search GeneIP for patents involving SLC31A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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