Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC31A1 Gene

protein-coding   GIFtS: 61
GCID: GC09P115983

Solute Carrier Family 31 (Copper Transporter), Member 1


(Previous symbol: COPT1)
  See SLC31A1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Solute Carrier Family 31 (Copper Transporter), Member 11 2     Copper Transport 1 Homolog (S. Cerevisiae)1
COPT11 2 3 5     Copper Transport 1 Homolog2
CTR12 3 5     High Affinity Copper Uptake Protein 12
Copper Transporter 12 3     Solute Carrier Family 31 (Copper Transporters), Member 12
Solute Carrier Family 31 Member 12 3     hCTR13

External Ids:    HGNC: 110161   Entrez Gene: 13172   Ensembl: ENSG000001368687   OMIM: 6030855   UniProtKB: O154313   
ORGUL members:         

Export aliases for SLC31A1 gene to outside databases

Previous GC identifers: GC09P106782 GC09P107716 GC09P109437 GC09P111359 GC09P113063 GC09P115023 GC09P085591


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC31A1 Gene:
The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded
protein functions as a homotrimer to effect the uptake of dietary copper. (provided by RefSeq, Aug 2011)

GeneCards Summary for SLC31A1 Gene:
SLC31A1 (solute carrier family 31 (copper transporter), member 1) is a protein-coding gene. Diseases associated with SLC31A1 include ethylmalonic encephalopathy, and wilson disease. GO annotations related to this gene include copper ion transmembrane transporter activity. An important paralog of this gene is SLC31A2.

UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431
Function: High-affinity, saturable copper transporter involved in dietary copper uptake

Gene Wiki entry for SLC31A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC31A1 gene promoter:
         SRF   E2F-3a   E2F-4   E2F-5   SRF (504 AA)   E2F-2   C/EBPalpha   PPAR-alpha   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC31A1 promoter sequence
   Search Chromatin IP Primers for SLC31A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC31A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q32   Ensembl cytogenetic band:  9q32   HGNC cytogenetic band: 9q32

SLC31A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC31A1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P115983:  view genomic region     (about GC identifiers)

Start:
115,983,808 bp from pter      End:
116,028,674 bp from pter
Size:
44,867 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431 (See protein sequence)
Recommended Name: High affinity copper uptake protein 1  
Size: 190 amino acids; 21091 Da
Subunit: Homotrimer
3 PDB 3D structures from and Proteopedia for SLC31A1:
2LS2 (3D)        2LS3 (3D)        2LS4 (3D)    
Secondary accessions: A8K8Z6 Q53GR5 Q5T1M4

Explore the universe of human proteins at neXtProt for SLC31A1: NX_O15431

Explore proteomics data for SLC31A1 at MOPED

Post-translational modifications: 

  • O-Glycosylation at Thr-27 protects from proteolytic cleavage in the N-terminal extracellular domain1
  • Glycosylation2 at Asn15, Thr27
  • Modification sites at PhosphoSitePlus

  • See SLC31A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001850.1  
    ENSEMBL proteins: 
     ENSP00000363329   ENSP00000363327  
    Reactome Protein details: O15431

    SLC31A1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for SLC31A1
    GenScript Custom Purified and Recombinant Proteins Services for SLC31A1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC31A1 

     
    Search antibodies-online for proteins for SLC31A1 

     
    antibodies-online peptides for SLC31A1

    SLC31A1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for SLC31A1
    OriGene Custom Antibody Services for SLC31A1
    Novus Biologicals SLC31A1 Antibodies
    Abcam antibodies for SLC31A1
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for SLC31A1
    antibodies-online antibodies for SLC31A1 (16 products) 

    SLC31A1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC31A1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC31A1
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC31A1 
    antibodies-online kits for SLC31A1 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Copper transporter 1
    SLC31 family of copper transporters

    1 InterPro protein domain:
     IPR007274 Cop_transporter

    Graphical View of Domain Structure for InterPro Entry O15431

    ProtoNet protein and cluster: O15431

    1 Blocks protein domain: IPB007274 Ctr copper transporter

    UniProtKB/Swiss-Prot: COPT1_HUMAN, O15431
    Similarity: Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily


    Find genes that share domains with SLC31A1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COPT1_HUMAN, O15431
    Function: High-affinity, saturable copper transporter involved in dietary copper uptake

         Genatlas biochemistry entry for SLC31A1:
    solute carrier family 31,copper uptake transport,high affinity,homolog to yeast ctr1,see D9S262,ubiquitously
    expressed

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005375copper ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC31A1           About GenesLikeMe


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc31a1):
     behavior/neurological  cardiovascular system  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     nervous system  other  pigmentation 

    Find genes that share phenotypes with SLC31A1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc31a1tm1Djt for SLC31A1

       genOway: Develop your customized and physiologically relevant rodent model for SLC31A1

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC31A1:
    hsa-mir-21-5p (MIRT030998), hsa-mir-183-5p (MIRT047052)

    Block miRNA regulation of human, mouse, rat SLC31A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC31A1 (see all 112):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-548j hsa-miR-607 hsa-miR-218-1* hsa-miR-938 hsa-miR-1260b hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC31A1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC31A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC31A1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC31A1

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC31A1 (see all 7)
    OriGene ORF clones in mouse, rat for SLC31A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC31A1 (NM_001859)
    Sino Biological Human cDNA Clone for SLC31A1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC31A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC31A1
    Addgene plasmids for SLC31A1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC31A1
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC31A1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    COPT1_HUMAN, O15431: Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in
    intestinal epithelial cells (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton1
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9207117
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with SLC31A1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC31A1 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    Platinum Pathway, Pharmacokinetics/Pharmacodynamics
    3Mineral absorption
    Mineral absorption
    4Metal ion SLC transporters
    Metal ion SLC transporters


    Find genes that share SuperPaths with SLC31A1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for SLC31A1
        Metal ion SLC transporters

    1 PharmGKB Pathway for SLC31A1
        Platinum Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for SLC31A1):
        Mineral absorption

        Pathway & Disease-focused RT2 Profiler PCR Array including SLC31A1: 
              Drug Transporters in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC31A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC31A1 (ENSP000003633294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZDHHC14ENSP000003528214STRING: ENSP00000352821
    ZDHHC18ENSP000003632574STRING: ENSP00000363257
    ZDHHC9ENSP000003496894STRING: ENSP00000349689
    UPF1ENSP000002628034STRING: ENSP00000262803
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006825copper ion transport TAS9207117
    GO:0035434copper ion transmembrane transport ----
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC31A1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC31A1 (COPT1)

    1 HMDB Compound for SLC31A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CopperCu (see all 2)7440-50-8--

    4 DrugBank Compounds for SLC31A1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CisplatinCDDP (see all 7)15663-27-1transportersubstrate19529937 18998134 20159940 19075668 19570948 19144690 19147760 15229296
    CarboplatinCBDCA (see all 2)41575-94-4transportersubstrate15634647 20159940
    OxaliplatinDiaminocyclohexane Oxalatoplatinum (see all 4)61825-94-3transportersubstrate15634647 20159940
    Bortezomib-- 179324-69-7transporterinhibitor19147760

    6 Novoseek inferred chemical compound relationships for SLC31A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    copper 82.5 211 14976198 (7), 15023397 (6), 12023893 (6), 12466020 (5) (see all 48)
    oxaliplatin 72.9 3 20159940 (1), 15229296 (1)
    cisplatin 71.6 85 15326162 (7), 19147760 (5), 20159940 (4), 15194000 (4) (see all 17)
    platinum 70.8 25 19147760 (2), 15326162 (1), 20159940 (1), 17097621 (1) (see all 7)
    carboplatin 63.8 3 20159940 (1), 15229296 (1)
    iron 38.7 3 18498772 (1), 9207117 (1)

    2 PharmGKB related drug/compound annotations for SLC31A1 gene    About this table
    Drug/compound PharmGKB Annotation
    carboplatinCA  
    cisplatinCA  



    Find genes that share compounds with SLC31A1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC31A1 gene: 
    NM_001859.3  

    Unigene Cluster for SLC31A1:

    Solute carrier family 31 (copper transporters), member 1
    Hs.532315  [show with all ESTs]
    Unigene Representative Sequence: NM_001859
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374212(uc004bgu.3) ENST00000496650 ENST00000374210(uc004bgv.4)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC31A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC31A1 (see all 112):
    hsa-miR-3130-5p hsa-miR-582-3p hsa-miR-548j hsa-miR-607 hsa-miR-218-1* hsa-miR-938 hsa-miR-1260b hsa-miR-219-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC31A1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC31A1
    Predesigned siRNA for gene silencing in human, mouse, rat SLC31A1
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC31A1 (see all 7)
    OriGene ORF clones in mouse, rat for SLC31A1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC31A1 (NM_001859)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC31A1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC31A1
    Addgene plasmids for SLC31A1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC31A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC31A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC31A1
      QuantiTect SYBR Green Assays in human, mouse, rat SLC31A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC31A1

    Additional mRNA sequence: 

    AK056926.1 AK129613.1 AK222866.1 AK292511.1 AL831843.1 BC004315.1 BC013611.1 BC061924.1 
    BC131730.1 U83460.1 

    13 DOTS entries:

    DT.452552  DT.91736059  DT.97819356  DT.447359  DT.75102150  DT.92430731  DT.100686986  DT.100819981 
    DT.120871167  DT.121172973  DT.75191783  DT.95270371  DT.92058887 

    Selected AceView cDNA sequences (see all 213):

    BG696740 AL120313 BQ318894 AA356345 AA878058 AI370733 BX282604 AA608729 
    BE728820 AA190729 BC061924 BM478744 N31448 AA568677 CR593760 CB162262 
    BM744252 BU630885 BE677227 BF942099 BU846259 CB106649 BC004315 BU616476 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC31A1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6
    SP1:                    -                       -         
    SP2:                    -                                 
    SP3:                    -     -                 -         
    SP4:                                                      


    ECgene alternative splicing isoforms for SLC31A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC31A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC31A1 Expression
    About this image


    SLC31A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Mature Choroid Plexus Cells Choroid Plexus
             Cerebral Cortex
     
     Epithelial Cells
             Mature Choroid Plexus Cells Choroid Plexus
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Diencephalic Roof Plate
    SLC31A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC31A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.532315
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC31A1: 
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC31A1
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC31A1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC31A1
    QuantiTect SYBR Green Assays in human, mouse, rat SLC31A1
    QuantiFast Probe-based Assays in human, mouse, rat SLC31A1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for SLC31A1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc31a11 , 5 solute carrier family 31, member 11, 5 90.96(n)1
    93.09(a)1
      4 (33.11 cM)5
    205291  NM_175090.41  NP_780299.21 
     623607275 
    chicken
    (Gallus gallus)
    Aves SLC31A11 solute carrier family 31 (copper transporters), member more 77.66(n)
    84.62(a)
      417268  XM_004945769.1  XP_004945826.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC31A16
    solute carrier family 31 (copper transporter), mem...
    80(a)
    1 ↔ 1
    GL344086.1(38023-59022)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC053785.12   -- 77.56(n)    BC053785.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.68472 Danio rerio high affinity copper uptake protein (ctr-1) more 75.16(n)    AY077715.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ctr1A1 Copper transporter 1A 56.44(n)
    50(a)
      31601  NM_001258623.1  NP_001245552.1 


    ENSEMBL Gene Tree for SLC31A1 (if available)
    TreeFam Gene Tree for SLC31A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC31A1 gene
    SLC31A22  

    Find genes that share paralogs with SLC31A1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC31A1
    PGOHUM00000237863


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC31A1 (see all 686)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485405111,2
    --115985876(+) AGTATA/GCAACT 1 -- int10--------
    rs1438956861,2
    --115985913(+) CAACCC/GCCAGA 1 -- int10--------
    rs1890031341,2
    --115986049(+) ATATAC/TGAGTA 1 -- int10--------
    rs1931452641,2
    --115986059(+) ATACCC/TATACT 1 -- int10--------
    rs1405360741,2
    --115986113(+) TATAAA/CCAAGT 1 -- int10--------
    rs778943161,2
    F--115986128(+) TCAGGC/TATAAT 1 -- int10--------
    rs1836420091,2
    --115986132(+) GCATAA/GTGATA 1 -- int10--------
    rs1512322801,2
    --115986261(+) ATACAA/GATAAT 1 -- int10--------
    rs1391779821,2
    --115986399(+) CACAGC/GCTTTC 1 -- int10--------
    rs109816941,2
    C,F,H--115986409(+) CTCATT/GTGTTT 1 -- int118Minor allele frequency- G:0.13NS EA NA 2252

    HapMap Linkage Disequilibrium report for SLC31A1 (115983808 - 116028674 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC31A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv893745CNV Loss21882294
    nsv893744CNV Gain21882294
    nsv893746CNV Gain21882294
    dgv2416e1CNV Complex17122850
    dgv2412e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): SLC31A1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC31A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC31A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603085    OMIM disorders: --

    2 diseases for SLC31A1:    
    About MalaCards
    ethylmalonic encephalopathy    wilson disease


    Find genes that share disorders with SLC31A1           About GenesLikeMe

    5 Novoseek inferred disease relationships for SLC31A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wilson disease 60.4 1 12023893 (1)
    ovarian carcinoma 51.4 7 15475465 (2), 19147760 (2), 20194531 (1), 15229296 (1)
    tumors 18.4 13 19470736 (4), 17015901 (1), 15229296 (1), 20159940 (1)
    ovarian cancer 3.94 3 19147760 (2), 20194531 (1), 20159940 (1)
    prostate cancer 0 2 17015901 (2)


    Export disorders for SLC31A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC31A1 gene, integrated from 10 sources (see all 94):
    (articles sorted by number of sources associating them with SLC31A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hCTR1: a human gene for copper uptake identified by complementation in yeast. (PubMed id 9207117)1, 2, 3, 9 Zhou B. and Gitschier J. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. (PubMed id 19147760)1, 7, 9 Jandial D.D....Howell S.B. (Clin. Cancer Res. 2009)
    3. Protein kinase inhibitors emodin and dichloro-ribofuranosylbenzimidazole modulate the cellular accumulation and cytotoxicity of cisplatin in a schedule-dependent manner. (PubMed id 19529937)1, 7, 9 Kurokawa T....Siddik Z.H. (Cancer Chemother. Pharmacol. 2010)
    4. The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity. (PubMed id 19144690)1, 7 Pabla N....Dong Z. (Am. J. Physiol. Renal Physiol. 2009)
    5. Projection structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. (PubMed id 16501047)1, 2 Aller S.G. and Unger V.M. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Biochemical characterization of the human copper transporter Ctr1. (PubMed id 11734551)1, 2 Lee J.... Thiele D.J. (J. Biol. Chem. 2002)
    9. Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1). (PubMed id 12023893)1, 9 Klomp A.E....Klomp L.W. (Biochem. J. 2002)
    10. The N-terminus of the human copper transporter 1 (hCTR1) is localized extracellularly, and interacts with itself. (PubMed id 12466020)1, 9 Klomp A.E....Klomp L.W. (Biochem. J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1317 HGNC: 11016 AceView: SLC31A1 Ensembl:ENSG00000136868 euGenes: HUgn1317
    ECgene: SLC31A1 Kegg: 1317 H-InvDB: SLC31A1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC31A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC31A1 gene:
    Search GeneIP for patents involving SLC31A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC31A1   OriGene RNAi products in human, mouse, rat for SLC31A1  
     OriGene qPCR primer pairs and template standards for SLC31A1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC31A1  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC31A1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC31A1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC31A1   OriGene Custom Protein Services for SLC31A1  

     
     
     Block miRNA regulation of human, mouse, rat SLC31A1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC31A1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC31A1 Predesigned siRNA for gene silencing in human, mouse, rat SLC31A1
     QuantiFast Probe-based Assays in human, mouse, rat SLC31A1 QuantiTect SYBR Green Assays in human, mouse, rat SLC31A1
     PCR Arrays including human, mouse, rat SLC31A1 Search Chromatin IP Primers for SLC31A1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC31A1  Search GeneGlobe Interaction Network for SLC31A1
     Regulatory tfbs in SLC31A1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC31A1 GenScript cDNA clones with any tag delivered in your preferred vector for SLC31A1
     GenScript Custom Assay Services for SLC31A1 GenScript Custom overexpressing Cell Line Services for SLC31A1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC31A1 (COPT1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for SLC31A1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC31A1 antibodies
     Antibodies for SLC31A1
     See all of Abcam's Antibodies, Kits and Proteins for SLC31A1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC31A1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC31A1
     SwitchGear 3'UTR luciferase reporter plasmids for SLC31A1
     SwitchGear Promoter luciferase reporter plasmids for SLC31A1
     ThermoFisher Antibodies for SLC31A1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC31A1
     Browse compounds at ApexBio
     Addgene plasmids for SLC31A1
      Search eBioscience for proteins for SLC31A1
      Search eBioscience for elisas for SLC31A1
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for SLC31A1
     antibodies-online antibodies for SLC31A1 (16 products)
     antibodies-online kits for SLC31A1 (11 products)
     antibodies-online peptides for SLC31A1
      Search antibodies-online for proteins for SLC31A1
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC31A1 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4