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Aliases for SLC30A9 Gene

Aliases for SLC30A9 Gene

  • Solute Carrier Family 30 Member 9 2 3 4
  • Solute Carrier Family 30 (Zinc Transporter), Member 9 2 3 5
  • GRIP1-Dependent Nuclear Receptor Coactivator 2 3
  • Human Embryonic Lung Protein 3 4
  • C4orf1 3 4
  • ZnT-9 3 4
  • HUEL 3 4
  • Chromosome 4 Open Reading Frame 1 2
  • Expressed In Human Embryonic Lung 3
  • GAC63 3
  • ZNT9 3

External Ids for SLC30A9 Gene

Previous HGNC Symbols for SLC30A9 Gene

  • C4orf1

Previous GeneCards Identifiers for SLC30A9 Gene

  • GC04P041842
  • GC04P041908
  • GC04P041834
  • GC04P041687
  • GC04P041314

Summaries for SLC30A9 Gene

GeneCards Summary for SLC30A9 Gene

SLC30A9 (Solute Carrier Family 30 Member 9) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and ligand-dependent nuclear receptor transcription coactivator activity.

UniProtKB/Swiss-Prot for SLC30A9 Gene

  • Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A9 Gene

Genomics for SLC30A9 Gene

Regulatory Elements for SLC30A9 Gene

Enhancers for SLC30A9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC30A9 on UCSC Golden Path with GeneCards custom track

Promoters for SLC30A9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC30A9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A9 Gene

41,990,472 bp from pter
42,090,457 bp from pter
99,986 bases
Plus strand

Genomic View for SLC30A9 Gene

Genes around SLC30A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A9 Gene

Proteins for SLC30A9 Gene

  • Protein details for SLC30A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter 9
    Protein Accession:
    Secondary Accessions:
    • Q4W5B6
    • Q7Z5I7
    • Q8TBB2
    • Q9Y6R2

    Protein attributes for SLC30A9 Gene

    568 amino acids
    Molecular mass:
    63515 Da
    Quaternary structure:
    • Interacts with GRIP1, ESR1 and AR.
    • Sequence=AAP83846.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAY40966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC30A9 Gene

neXtProt entry for SLC30A9 Gene

Proteomics data for SLC30A9 Gene at MOPED

Post-translational modifications for SLC30A9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A9 Gene

Domains & Families for SLC30A9 Gene

Gene Families for SLC30A9 Gene

Protein Domains for SLC30A9 Gene

Suggested Antigen Peptide Sequences for SLC30A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A9: view

Function for SLC30A9 Gene

Molecular function for SLC30A9 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.

Gene Ontology (GO) - Molecular Function for SLC30A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016922 ligand-dependent nuclear receptor binding IEA --
genes like me logo Genes that share ontologies with SLC30A9: view
genes like me logo Genes that share phenotypes with SLC30A9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A9

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A9 Gene

Localization for SLC30A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A9 Gene

Membrane; Multi-pass membrane protein. Nucleus.

Subcellular locations from

Jensen Localization Image for SLC30A9 Gene COMPARTMENTS Subcellular localization image for SLC30A9 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
mitochondrion 2

No data available for Gene Ontology (GO) - Cellular Components for SLC30A9 Gene

Pathways & Interactions for SLC30A9 Gene

SuperPathways for SLC30A9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC30A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair TAS 17349999
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
GO:0055085 transmembrane transport IEA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC30A9: view

No data available for Pathways by source and SIGNOR curated interactions for SLC30A9 Gene

Drugs & Compounds for SLC30A9 Gene

(1) Drugs for SLC30A9 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aspirin Approved Pharma Channel blocker 1059
genes like me logo Genes that share compounds with SLC30A9: view

Transcripts for SLC30A9 Gene

Unigene Clusters for SLC30A9 Gene

Solute carrier family 30 (zinc transporter), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -

Relevant External Links for SLC30A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC30A9 Gene

mRNA expression in normal human tissues for SLC30A9 Gene

Protein differential expression in normal tissues from HIPED for SLC30A9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A9 Gene

SOURCE GeneReport for Unigene cluster for SLC30A9 Gene Hs.479634

mRNA Expression by UniProt/SwissProt for SLC30A9 Gene

Tissue specificity: Ubiquitously expressed in fetal and adult tissues and cancer cell lines.
genes like me logo Genes that share expression patterns with SLC30A9: view

Protein tissue co-expression partners for SLC30A9 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC30A9 Gene

Orthologs for SLC30A9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC30A9 35
  • 92.24 (n)
  • 94.85 (a)
SLC30A9 36
  • 95 (a)
(Canis familiaris)
Mammalia SLC30A9 35
  • 92.79 (n)
  • 94.92 (a)
SLC30A9 36
  • 95 (a)
(Mus musculus)
Mammalia Slc30a9 35
  • 87.43 (n)
  • 89.38 (a)
Slc30a9 16
Slc30a9 36
  • 89 (a)
(Pan troglodytes)
Mammalia SLC30A9 35
  • 99.47 (n)
  • 99.65 (a)
SLC30A9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc30a9 35
  • 86.37 (n)
  • 88.67 (a)
(Monodelphis domestica)
Mammalia SLC30A9 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia SLC30A9 36
  • 80 (a)
(Gallus gallus)
Aves SLC30A9 35
  • 75.22 (n)
  • 79.43 (a)
SLC30A9 36
  • 70 (a)
(Anolis carolinensis)
Reptilia SLC30A9 36
  • 72 (a)
(Danio rerio)
Actinopterygii slc30a9 35
  • 68.03 (n)
  • 74.15 (a)
slc30a9 36
  • 72 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012046 35
  • 53.81 (n)
  • 54.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8632 35
  • 54.92 (n)
  • 54.69 (a)
CG8632 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea Y71H2AM.9 35
  • 49.07 (n)
  • 45.33 (a)
Y71H2AM.9 36
  • 41 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51610 35
  • 49.04 (n)
  • 39.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10925 36
  • 53 (a)
Species with no ortholog for SLC30A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC30A9 Gene

Gene Tree for SLC30A9 (if available)
Gene Tree for SLC30A9 (if available)

Paralogs for SLC30A9 Gene

No data available for Paralogs for SLC30A9 Gene

Variants for SLC30A9 Gene

Sequence variations from dbSNP and Humsavar for SLC30A9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1047626 - 42,001,654(+) CAAAC(A/G)TGGTT reference, missense
rs2581423 - 42,018,125(-) TTCTG(A/C/T)GCCTA reference, missense
rs1801962 - 42,065,335(+) ATCAT(C/T)AGTAT reference, missense
rs11051 -- 42,087,160(+) CTTCA(A/G)TTACA utr-variant-3-prime
rs15857 -- 42,020,447(+) TATGG(A/C)TCAAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for SLC30A9 Gene

Variant ID Type Subtype PubMed ID
dgv5529n71 CNV Loss 21882294
nsv878960 CNV Loss 21882294
dgv5530n71 CNV Loss 21882294
dgv5531n71 CNV Loss 21882294
dgv5532n71 CNV Loss 21882294
esv2565491 CNV Deletion 19546169
esv2727490 CNV Deletion 23290073
esv3417 CNV Deletion 18987735
esv2533350 CNV Deletion 19546169
esv267965 CNV Insertion 20981092
esv273253 CNV Insertion 20981092
nsv291842 CNV Loss 16902084

Variation tolerance for SLC30A9 Gene

Residual Variation Intolerance Score: 27.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A9 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A9 Gene

Disorders for SLC30A9 Gene

Relevant External Links for SLC30A9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC30A9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A9 Gene

Publications for SLC30A9 Gene

  1. The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif. (PMID: 10409434) Sim D.L.C. … Chow V.T.K. (Genomics 1999) 2 3 4 23 67
  2. The novel human HUEL (C4orf1) protein shares homology with the DNA- binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. (PMID: 11906820) Sim D.L.C. … Chow V.T.K. (Int. J. Biochem. Cell Biol. 2002) 2 3 23
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. (PMID: 25476789) Galligan J.T. … Howley P.M. (J. Proteome Res. 2015) 3
  5. Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9, ZIP11, ZnT9) in Gliomas and their Correlation with IDH1 Mutation Status. (PMID: 25921144) Kang X. … Wang H.J. (Asian Pac. J. Cancer Prev. 2015) 3

Products for SLC30A9 Gene

Sources for SLC30A9 Gene