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Aliases for SLC30A9 Gene

Aliases for SLC30A9 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 9 2 3
  • C4orf1 3 4 6
  • HUEL 3 4 6
  • GRIP1-Dependent Nuclear Receptor Coactivator 2 3
  • Solute Carrier Family 30 Member 9 3 4
  • Human Embryonic Lung Protein 3 4
  • ZnT-9 3 4
  • Chromosome 4 Open Reading Frame 1 2
  • Expressed In Human Embryonic Lung 3
  • Zinc Transporter 9 3
  • GAC63 3
  • ZNT9 3

External Ids for SLC30A9 Gene

Previous HGNC Symbols for SLC30A9 Gene

  • C4orf1

Previous GeneCards Identifiers for SLC30A9 Gene

  • GC04P041842
  • GC04P041908
  • GC04P041834
  • GC04P041687
  • GC04P041314

Summaries for SLC30A9 Gene

GeneCards Summary for SLC30A9 Gene

SLC30A9 (Solute Carrier Family 30 (Zinc Transporter), Member 9) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and nucleotide binding.

UniProtKB/Swiss-Prot for SLC30A9 Gene

  • Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A9 Gene

Genomics for SLC30A9 Gene

Regulatory Elements for SLC30A9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A9 Gene

Start:
41,990,472 bp from pter
End:
42,090,457 bp from pter
Size:
99,986 bases
Orientation:
Plus strand

Genomic View for SLC30A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A9 Gene

Proteins for SLC30A9 Gene

  • Protein details for SLC30A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PML9-ZNT9_HUMAN
    Recommended name:
    Zinc transporter 9
    Protein Accession:
    Q6PML9
    Secondary Accessions:
    • Q4W5B6
    • Q7Z5I7
    • Q8TBB2
    • Q9Y6R2

    Protein attributes for SLC30A9 Gene

    Size:
    568 amino acids
    Molecular mass:
    63515 Da
    Quaternary structure:
    • Interacts with GRIP1, ESR1 and AR.
    SequenceCaution:
    • Sequence=AAP83846.1; Type=Miscellaneous discrepancy; Note=Unlikely isoform. Aberrant splice sites.; Evidence={ECO:0000305}; Sequence=AAY40966.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC30A9 Gene

neXtProt entry for SLC30A9 Gene

Proteomics data for SLC30A9 Gene at MOPED

Post-translational modifications for SLC30A9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC30A9 Gene

Domains for SLC30A9 Gene

Gene Families for SLC30A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A9 Gene

Suggested Antigen Peptide Sequences for SLC30A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PML9

UniProtKB/Swiss-Prot:

ZNT9_HUMAN :
  • Q6PML9
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A9: view

Function for SLC30A9 Gene

Molecular function for SLC30A9 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the p160 coactivator signaling pathway that mediates transcriptional activation by nuclear receptors. Plays a role in transcriptional activation of Wnt-responsive genes.

Gene Ontology (GO) - Molecular Function for SLC30A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 10409434
GO:0008324 cation transmembrane transporter activity IEA --
GO:0016922 ligand-dependent nuclear receptor binding IEA --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IEA --
genes like me logo Genes that share ontologies with SLC30A9: view

Phenotypes for SLC30A9 Gene

genes like me logo Genes that share phenotypes with SLC30A9: view

Animal Model Products

CRISPR Products

miRNA for SLC30A9 Gene

miRTarBase miRNAs that target SLC30A9

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A9 Gene

Localization for SLC30A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A9 Gene

Membrane; Multi-pass membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A9 Gene COMPARTMENTS Subcellular localization image for SLC30A9 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for SLC30A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10409434
GO:0005856 cytoskeleton IDA 10409434
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A9: view

Pathways for SLC30A9 Gene

SuperPathways for SLC30A9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC30A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair TAS 17349999
GO:0006351 transcription, DNA-templated IEA --
GO:0006812 cation transport --
GO:0006829 zinc II ion transport IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with SLC30A9: view

No data available for Pathways by source for SLC30A9 Gene

Transcripts for SLC30A9 Gene

Unigene Clusters for SLC30A9 Gene

Solute carrier family 30 (zinc transporter), member 9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1: - - -
SP2:
SP3:
SP4:
SP5:

Relevant External Links for SLC30A9 Gene

GeneLoc Exon Structure for
SLC30A9
ECgene alternative splicing isoforms for
SLC30A9

Expression for SLC30A9 Gene

mRNA expression in normal human tissues for SLC30A9 Gene

Protein differential expression in normal tissues for SLC30A9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Tlymphocyte (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC30A9 Gene

SOURCE GeneReport for Unigene cluster for SLC30A9 Gene Hs.479634

mRNA Expression by UniProt/SwissProt for SLC30A9 Gene

Q6PML9-ZNT9_HUMAN
Tissue specificity: Ubiquitously expressed in fetal and adult tissues and cancer cell lines.
genes like me logo Genes that share expressions with SLC30A9: view

Expression partners for SLC30A9 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC30A9 Gene

Orthologs for SLC30A9 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A9 35
  • 92.24 (n)
  • 94.85 (a)
SLC30A9 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A9 35
  • 92.79 (n)
  • 94.92 (a)
SLC30A9 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a9 35
  • 87.43 (n)
  • 89.38 (a)
Slc30a9 16
Slc30a9 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A9 35
  • 99.47 (n)
  • 99.65 (a)
SLC30A9 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a9 35
  • 86.37 (n)
  • 88.67 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC30A9 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A9 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A9 35
  • 75.22 (n)
  • 79.43 (a)
SLC30A9 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A9 36
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii slc30a9 35
  • 68.03 (n)
  • 74.15 (a)
slc30a9 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012046 35
  • 53.81 (n)
  • 54.53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8632 35
  • 54.92 (n)
  • 54.69 (a)
CG8632 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.9 35
  • 49.07 (n)
  • 45.33 (a)
Y71H2AM.9 36
  • 41 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G51610 35
  • 49.04 (n)
  • 39.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10925 36
  • 53 (a)
OneToOne
Species with no ortholog for SLC30A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC30A9 Gene

ENSEMBL:
Gene Tree for SLC30A9 (if available)
TreeFam:
Gene Tree for SLC30A9 (if available)

Paralogs for SLC30A9 Gene

No data available for Paralogs for SLC30A9 Gene

Variants for SLC30A9 Gene

Sequence variations from dbSNP and Humsavar for SLC30A9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11051 -- 42,087,160(+) CTTCA(A/G)TTACA utr-variant-3-prime
rs15857 -- 42,020,447(+) TATGG(A/C)TCAAA synonymous-codon, reference
rs17044 -- 42,080,462(-) ACTAT(A/G)CATTA intron-variant
rs876910 -- 42,029,167(-) GTGGG(C/T)GGCTT intron-variant
rs876911 -- 42,029,159(-) CTTCG(C/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A9 Gene

Variant ID Type Subtype PubMed ID
dgv5529n71 CNV Loss 21882294
nsv878960 CNV Loss 21882294
dgv5530n71 CNV Loss 21882294
dgv5531n71 CNV Loss 21882294
dgv5532n71 CNV Loss 21882294
esv2565491 CNV Deletion 19546169
esv2727490 CNV Deletion 23290073
esv3417 CNV Deletion 18987735
esv2533350 CNV Deletion 19546169
esv267965 CNV Insertion 20981092
esv273253 CNV Insertion 20981092
nsv291842 CNV Loss 16902084

Relevant External Links for SLC30A9 Gene

HapMap Linkage Disequilibrium report
SLC30A9
Human Gene Mutation Database (HGMD)
SLC30A9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A9 Gene

Disorders for SLC30A9 Gene

Relevant External Links for SLC30A9

Genetic Association Database (GAD)
SLC30A9
Human Genome Epidemiology (HuGE) Navigator
SLC30A9

No disorders were found for SLC30A9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC30A9 Gene

Publications for SLC30A9 Gene

  1. The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif. (PMID: 10409434) Sim D.L.C. … Chow V.T.K. (Genomics 1999) 2 3 4 23
  2. The novel human HUEL (C4orf1) protein shares homology with the DNA- binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. (PMID: 11906820) Sim D.L.C. … Chow V.T.K. (Int. J. Biochem. Cell Biol. 2002) 2 3 23
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for SLC30A9 Gene

Sources for SLC30A9 Gene

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