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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC30A8 Gene

protein-coding   GIFtS: 58
GCID: GC08P117963

Solute Carrier Family 30 (Zinc Transporter), Member 8

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 81 2
ZNT82 3 5
ZnT-82 3
Zinc Transporter 82
Zinc Transporter ZnT-82
Solute Carrier Family 30 Member 83

External Ids:    HGNC: 203031   Entrez Gene: 1690262   Ensembl: ENSG000001647567   OMIM: 6111455   UniProtKB: Q8IWU43   

Export aliases for SLC30A8 gene to outside databases

Previous GC identifers: GC08P118024 GC08P117632 GC08P118104 GC08P118032 GC08P118216 GC08P113288


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC30A8 Gene:
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in
intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of
Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the
insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes
mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Mar 2010)

GeneCards Summary for SLC30A8 Gene: 
SLC30A8 (solute carrier family 30 (zinc transporter), member 8) is a protein-coding gene. Diseases associated with SLC30A8 include diabetes mellitus, and type 1 diabetes, and among its related super-pathways are Transmembrane transport of small molecules and Zinc transporters. GO annotations related to this gene include zinc ion transmembrane transporter activity and protein homodimerization activity. An important paralog of this gene is SLC30A3.

UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux
transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in
insulin-secreting pancreatic beta-cells

Gene Wiki entry for SLC30A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC30A8 gene promoter:
         AP-4   CUTL1   Tal-1beta   PPAR-gamma1   POU2F1   FOXO4   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A8 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC30A8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.11   Ensembl cytogenetic band:  8q24.11   HGNC cytogenetic band: 8q24.11

SLC30A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P117963:  view genomic region     (about GC identifiers)

Start:
117,962,512 bp from pter      End:
118,188,953 bp from pter
Size:
226,442 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4 (See protein sequence)
Recommended Name: Zinc transporter 8  
Size: 369 amino acids; 40755 Da
Subunit: Homodimer (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory
vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory
granules (By similarity)
Secondary accessions: A0AVP9 A5YM39 B4DPE0 Q8TCL3
Alternative splicing: 2 isoforms:  Q8IWU4-1   Q8IWU4-2   

Explore the universe of human proteins at neXtProt for SLC30A8: NX_Q8IWU4

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IWU4

  • SLC30A8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (5 alternative transcripts): 
    NP_001166282.1  NP_001166284.1  NP_001166285.1  NP_001166286.1  NP_776250.2  

    ENSEMBL proteins: 
     ENSP00000428545   ENSP00000427760   ENSP00000431069   ENSP00000415011   ENSP00000407505  
    Reactome Protein details: Q8IWU4
    Human Recombinant Protein Products for SLC30A8: 
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    Cloud-Clone Corp. Proteins for SLC30A8 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794NOT Golgi apparatus IDA15331542
    GO:0005886plasma membrane IDA15331542
    GO:0016021integral to membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle ISS--
    GO:0030141secretory granule IDA15331542

    SLC30A8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 8 
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q8IWU4

    ProtoNet protein and cluster: Q8IWU4

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
    Domain: Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc (By similarity)
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    SLC30A8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT8_HUMAN, Q8IWU4
    Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux
    transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in
    insulin-secreting pancreatic beta-cells

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IDA15331542
    GO:0008270zinc ion binding IC15331542
    GO:0008324cation transmembrane transporter activity ----
    GO:0042803protein homodimerization activity ISS--
         
    SLC30A8 for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Slc30a8):
     endocrine/exocrine gland  growth/size  homeostasis/metabolism  no phenotypic analysis  pigmentation 
     vision/eye 

    SLC30A8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc30a8tm1.1Geno for SLC30A8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC30A8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC30A8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Zinc transporters
    Zinc transporters0.68
    Zinc efflux and compartmentalization by the SLC30 family0.41
    Metal ion SLC transporters0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/6        Reactome Pathways for SLC30A8 (see all 6)
        Zinc efflux and compartmentalization by the SLC30 family
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters



    SLC30A8 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC30A8

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006829zinc ion transport IDA15331542
    GO:0006882cellular zinc ion homeostasis ISS--
    GO:0009749response to glucose stimulus IMP16984975
    GO:0030073insulin secretion IMP16984975

    SLC30A8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC30A8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC30A8 (ZNT8)

    1 Novoseek inferred chemical compound relationship for SLC30A8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 72 32 16984975 (2), 19817803 (2), 19706465 (2), 19450229 (2) (see all 16)

    Search CenterWatch for drugs/clinical trials and news about SLC30A8 / ZNT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC30A8 gene (5 alternative transcripts): 
    NM_001172811.1  NM_001172813.1  NM_001172814.1  NM_001172815.1  NM_173851.2  

    Unigene Cluster for SLC30A8:

    Solute carrier family 30 (zinc transporter), member 8
    Hs.532270  [show with all ESTs]
    Unigene Representative Sequence: NM_001172813
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521243 ENST00000524274 ENST00000521035 ENST00000518521 ENST00000518396
    ENST00000520469 ENST00000519688 ENST00000456015 ENST00000427715(uc010mcz.3 uc003yog.3 uc011lia.2 uc022bab.1 uc003yoh.3)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK298294.1 AL713790.1 AY117411.1 BC015845.1 BC126446.1 BC143953.1 EF560713.1 

    4 DOTS entries:

    DT.100813904  DT.95232711  DT.100813905  DT.121491322 

    24/134 AceView cDNA sequences (see all 134):

    BM507349 CB178383 BU070527 BQ477466 CB158043 AW300204 BQ267753 CA773127 
    BQ549196 BQ267403 CA772124 BU789025 CA952877 CB068724 CA771127 BM272538 
    BU070764 BU947651 CA867469 CB068938 BM511828 BM512526 BU949577 CA952713 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC30A8 expression in normal human tissues (normalized intensities)      SLC30A8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGGGCACA
    SLC30A8 Expression
    About this image


    SLC30A8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine Progenitor Cells Ventral Pancreatic Bud

    Genevestigator expression for SLC30A8

    SOURCE GeneReport for Unigene cluster: Hs.532270

    UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
    Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively
    high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or
    obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood
    mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to
    strongly positive

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC30A8 gene from 10/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a81 , 5 solute carrier family 30 (zinc transporter), member more1, 5 82.92(n)1
    80.93(a)1
      15 (19.88 cM)5
    2394361  NM_172816.31  NP_766404.11 
     522955535 
    chicken
    (Gallus gallus)
    Aves SLC30A81 solute carrier family 30 (zinc transporter), member more 65.66(n)
    61.43(a)
      420285  XM_418398.3  XP_418398.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A86
    solute carrier family 30 (zinc transporter), membe...
    54(a)
    1 ↔ 1
    4(6974384-6987759)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.275132 Xenopus laevis transcribed sequence with weak similarity more 77(n)    BJ038722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5606421 zinc transporter 8-like 61.85(n)
    57.23(a)
      560642  XM_684037.4  XP_689129.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZnT35C6
    CG111636
    (see all 3)
    --
    30(a)
    23(a)
    (see all 3)
    many ↔ many
    possible ortholog
    (see all 3)
    2L(15228728-15247832)
    2R(1662279-1670360)
    worm
    (Caenorhabditis elegans)
    Secernentea cdf-26
    ttm-16
    (see all 3)
    Protein TTM-1, isoform a
    (see all 3)
    38(a)
    31(a)
    (see all 3)
    many → 1
    possible ortholog
    (see all 3)
    X(12464648-12466878)
    III(12952970-12966995)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZRC16
    COT16
    Vacuolar membrane zinc transporter, transports zin...
    Vacuolar transporter that mediates zinc transport ...
    20(a)
    17(a)
    many ↔ many
    many ↔ many
    XIII(754838-756166)
    XV(906236-907555)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZAT1 metal tolerance protein 1 short form 48.99(n)
    38.93(a)
      819293  NM_180128.2  NP_850459.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01284001 hypothetical protein 50(n)
    40.94(a)
      4337694  NM_001061074.1  NP_001054539.1 


    ENSEMBL Gene Tree for SLC30A8 (if available)
    TreeFam Gene Tree for SLC30A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC30A8 gene
    SLC30A32  SLC30A22  SLC30A102  SLC30A42  SLC30A12  
    4 SIMAP similar genes for SLC30A8 using alignment to 2 protein entries:     ZNT8_HUMAN (see all proteins):
    ZNT4    SLC30A3    SLC30A4    SLC30A2

    SLC30A8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
    Polymorphism: Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus,
    noninsulin-dependent (NIDDM) [MIM:125853]


    10/4558 SNPs in SLC30A8 are shown (see all 4558)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs132666341,2,4
    C,F,Hother1118455543(+) CCAGCC/TGGGAC 10 R W mis1 ese326Minor allele frequency- T:0.23EA NA NS WA EU 8495
    rs1136096911,2
    C--113294355(+) AAAAAG/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs1410791021,2
    C--113353708(+) TACAA-/ATATATA 3 -- int10--------
    rs347487481,2
    C--113353709(+) ATATA-/AT/TA 
            
    GATAT
    3 -- int10--------
    rs1996745901,2
    C--113354241(+) CCCCCA/CCAAAA 3 -- int10--------
    rs1493853151,2
    C--113359236(+) TGGAT-/ATCATACA 3 -- cds10--------
    rs1508560001,2
    C--113359237(+) GGATA-/ATCTACAG 3 -- cds10--------
    rs1139770421,2
    C--113449198(+) TACTT-/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
    rs126744901,2
    H--113505709(+) ttttGG/TCCAGC 5 -- int10--------
    rs733102881,2
    C,F--117961316(+) TCAGAG/ATTTCT 3 -- us2k13Minor allele frequency- A:0.15WA CSA 122

    HapMap Linkage Disequilibrium report for SLC30A8 (117962512 - 118188953 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for SLC30A8:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1303e199CNV Deletion23128226
    esv2670074CNV Deletion23128226
    nsv819890CNV Loss19587683
    nsv527876CNV Loss19592680
    nsv6360CNV Loss18451855
    esv21665CNV Loss19812545
    nsv891409CNV Loss21882294
    nsv819760CNV Gain19587683
    nsv831434CNV Gain17160897


    Human Gene Mutation Database (HGMD): SLC30A8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611145   
    OMIM disorders: 125853  
    16 diseases for SLC30A8:    About MalaCards
    diabetes mellitus    type 1 diabetes    gestational diabetes    insulinoma
    type 1 diabetes mellitus    polycystic ovary syndrome    coronary heart disease    insulin resistance
    obesity    atherosclerosis    asthma    pneumonia
    schizophrenia    prostate cancer    pancreatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLC30A8:
    Diabetes mellitus

    SLC30A8 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for SLC30A8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmunity 46.8 2 19590848 (1), 19120306 (1)

    Genetic Association Database (GAD): SLC30A8
    Human Genome Epidemiology (HuGE) Navigator: SLC30A8 (112 documents)

    Export disorders for SLC30A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC30A8 gene, integrated from 9 sources (see all 171):
    (articles sorted by number of sources associating them with SLC30A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study identifies novel risk loci for type 2 diabetes. (PubMed id 17293876)1, 2, 4 Sladek R....Froguel P. (2007)
    2. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. (PubMed id 18850084)1, 4, 9 Kawasaki E....Eguchi K. (2008)
    3. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. (PubMed id 15331542)1, 2, 9 Chimienti F.... Seve M. (2004)
    4. ZnT-8, a pancreatic beta-cell-specific zinc transporter. (PubMed id 16158222)1, 2, 9 Chimienti F.... Seve M. (2005)
    5. Autoantibodies to zinc transporter 8 and SLC30A8 geno type stratify type 1 diabetes risk. (PubMed id 19590848)1, 4, 9 Achenbach P....Ziegler A.G. (2009)
    6. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset. (PubMed id 18548167)1, 4, 9 Gohlke H....Ziegler A.G. (2008)
    7. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. (PubMed id 16984975)1, 2, 9 Chimienti F....Seve M. (2006)
    8. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. (PubMed id 18324385)1, 4, 9 Boesgaard T.W....Hansen T. (2008)
    9. Meta-analysis and functional effects of the SLC30A8 r s13266634 polymorphism on isolated human pancreatic islets. (PubMed id 20138556)1, 4, 9 Cauchi S....Marchetti P. (2010)
    10. Genome-wide association identifies nine common variant s associated with fasting proinsulin levels and provides new insights into the p athophysiology of type 2 diabetes. (PubMed id 21873549)1, 4 Strawbridge R.J....Florez J.C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 169026 HGNC: 20303 AceView: SLC30A8 Ensembl:ENSG00000164756 euGenes: HUgn169026
    ECgene: SLC30A8 H-InvDB: SLC30A8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC30A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC30A8 gene:
    Search GeneIP for patents involving SLC30A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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