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SLC30A8 Gene

protein-coding   GIFtS: 56
GCID: GC08P117963

Solute Carrier Family 30 (Zinc Transporter), Member 8

  See SLC30A8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 81 2
ZNT82 3 5
ZnT-82 3
Zinc Transporter 82
Zinc Transporter ZnT-82
Solute Carrier Family 30 Member 83

External Ids:    HGNC: 203031   Entrez Gene: 1690262   Ensembl: ENSG000001647567   OMIM: 6111455   UniProtKB: Q8IWU43   

Export aliases for SLC30A8 gene to outside databases

Previous GC identifers: GC08P118024 GC08P117632 GC08P118104 GC08P118032 GC08P118216 GC08P113288


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC30A8 Gene:
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in
intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of
Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the
insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes
mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found
for this gene.(provided by RefSeq, Mar 2010)

GeneCards Summary for SLC30A8 Gene:
SLC30A8 (solute carrier family 30 (zinc transporter), member 8) is a protein-coding gene. Diseases associated with SLC30A8 include diabetes mellitus, noninsulin-dependent, and diabetes mellitus. GO annotations related to this gene include zinc ion transmembrane transporter activity and protein homodimerization activity. An important paralog of this gene is SLC30A3.

UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux
transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in
insulin-secreting pancreatic beta-cells

Gene Wiki entry for SLC30A8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008046.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A8 gene promoter:
         AP-4   CUTL1   Tal-1beta   PPAR-gamma1   POU2F1   FOXO4   POU2F1b   POU2F1a   POU2F1c   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A8 promoter sequence
   Search Chromatin IP Primers for SLC30A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.11   Ensembl cytogenetic band:  8q24.11   HGNC cytogenetic band: 8q24.11

SLC30A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P117963:  view genomic region     (about GC identifiers)

Start:
117,962,512 bp from pter      End:
118,188,953 bp from pter
Size:
226,442 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4 (See protein sequence)
Recommended Name: Zinc transporter 8  
Size: 369 amino acids; 40755 Da
Subunit: Homodimer (By similarity)
Secondary accessions: A0AVP9 A5YM39 B4DPE0 Q8TCL3
Alternative splicing: 2 isoforms:  Q8IWU4-1   Q8IWU4-2   

Explore the universe of human proteins at neXtProt for SLC30A8: NX_Q8IWU4

Explore proteomics data for SLC30A8 at MOPED


See SLC30A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (5 alternative transcripts): 
NP_001166282.1  NP_001166284.1  NP_001166285.1  NP_001166286.1  NP_776250.2  

ENSEMBL proteins: 
 ENSP00000428545   ENSP00000427760   ENSP00000431069   ENSP00000415011   ENSP00000407505  
Reactome Protein details: Q8IWU4

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 8
SLC30 zinc transporter family

2 InterPro protein domains:
 IPR027469 Cation_efflux_TMD
 IPR002524 Cation_efflux

Graphical View of Domain Structure for InterPro Entry Q8IWU4

ProtoNet protein and cluster: Q8IWU4

1 Blocks protein domain: IPB002524 Cation efflux protein

UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
Domain: Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc (By similarity)
Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


Find genes that share domains with SLC30A8           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ZNT8_HUMAN, Q8IWU4
Function: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux
transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in
insulin-secreting pancreatic beta-cells

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005385zinc ion transmembrane transporter activity IDA15331542
GO:0008270zinc ion binding IC15331542
GO:0008324cation transmembrane transporter activity ----
GO:0042803protein homodimerization activity ISS--
     
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Phenotypes:
     7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Slc30a8):
 endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  liver/biliary system  no phenotypic analysis 
 pigmentation  vision/eye 

Find genes that share phenotypes with SLC30A8           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Slc30a8tm1.1Geno for SLC30A8

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC30A8
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
ZNT8_HUMAN, Q8IWU4: Cell membrane; Multi-pass membrane protein (Probable). Cytoplasmic vesicle, secretory
vesicle membrane; Multi-pass membrane protein (Probable). Note=Associated with insulin and glucagon secretory
granules (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane5
peroxisome1

Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005794NOT Golgi apparatus IDA15331542
GO:0005886plasma membrane IDA15331542
GO:0016021integral component of membrane IEA--
GO:0016023cytoplasmic membrane-bounded vesicle ISS--
GO:0030141secretory granule IDA15331542

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for SLC30A8 About    
See pathways by source

SuperPathContained pathways About
1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
SLC-mediated transmembrane transport0.47
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
Transmembrane transport of small molecules0.47
2Metal ion SLC transporters
Metal ion SLC transporters
Zinc transporters0.00
Zinc efflux and compartmentalization by the SLC30 family0.00


Find genes that share SuperPaths with SLC30A8           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Reactome Pathway for SLC30A8
    Zinc efflux and compartmentalization by the SLC30 family


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Interactions:

    GeneGlobe Interaction Network for SLC30A8

Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006812cation transport ----
GO:0006829zinc ion transport IDA15331542
GO:0006882cellular zinc ion homeostasis ISS--
GO:0009749response to glucose IMP16984975
GO:0030073insulin secretion IMP16984975

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for SLC30A8 (ZNT8)

1 Novoseek inferred chemical compound relationship for SLC30A8 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
zinc 72 32 16984975 (2), 19817803 (2), 19706465 (2), 19450229 (2) (see all 16)

1 PharmGKB related drug/compound annotation for SLC30A8 gene    About this table
Drug/compound PharmGKB Annotation
repaglinideCA  



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for SLC30A8 gene (5 alternative transcripts): 
NM_001172811.1  NM_001172813.1  NM_001172814.1  NM_001172815.1  NM_173851.2  

Unigene Cluster for SLC30A8:

Solute carrier family 30 (zinc transporter), member 8
Hs.532270  [show with all ESTs]
Unigene Representative Sequence: NM_001172813
9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000521243 ENST00000524274 ENST00000521035 ENST00000518521 ENST00000518396
ENST00000520469 ENST00000519688 ENST00000456015 ENST00000427715(uc010mcz.3 uc003yog.3 uc011lia.2 uc022bab.1 uc003yoh.3)

miRNA
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hsa-miR-2052 hsa-miR-4291 hsa-miR-3678-3p hsa-miR-576-3p hsa-miR-3607-3p hsa-miR-640 hsa-miR-4254 hsa-miR-562
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Primer
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  QuantiFast Probe-based Assays in human, mouse, rat SLC30A8

Additional mRNA sequence: 

AK298294.1 AL713790.1 AY117411.1 BC015845.1 BC126446.1 BC143953.1 EF560713.1 

4 DOTS entries:

DT.100813904  DT.95232711  DT.100813905  DT.121491322 

Selected AceView cDNA sequences (see all 134):

CB178383 BU070527 BQ477466 CB158043 AW300204 BQ267753 CA773127 BQ549196 
BQ267403 CA772124 BU789025 CA952877 CB068724 CA771127 BM272538 BU070764 
BU947651 CA867469 CB068938 BM511828 BM512526 BU949577 CA952713 BU074261 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC30A8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTGGGCACA
SLC30A8 Expression
About this image


SLC30A8 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Endocrine Progenitor Cells Ventral Pancreatic Bud
SLC30A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

SLC30A8 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.532270

UniProtKB/Swiss-Prot: ZNT8_HUMAN, Q8IWU4
Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively
high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or
obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood
mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to
strongly positive

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A8 gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Slc30a81 , 5 solute carrier family 30 (zinc transporter), member more1, 5 82.92(n)1
80.93(a)1
  15 (19.88 cM)5
2394361  NM_172816.31  NP_766404.11 
 522955535 
chicken
(Gallus gallus)
Aves SLC30A81 solute carrier family 30 (zinc transporter), member more 66.03(n)
61.81(a)
  420285  XM_418398.4  XP_418398.4 
lizard
(Anolis carolinensis)
Reptilia SLC30A86
solute carrier family 30 (zinc transporter), membe...
54(a)
1 ↔ 1
4(6974384-6987759)
African clawed frog
(Xenopus laevis)
Amphibia Xl.275132 Xenopus laevis transcribed sequence with weak similarity more 77(n)    BJ038722.1 
zebrafish
(Danio rerio)
Actinopterygii LOC5606421 zinc transporter 8-like 62.24(n)
57.23(a)
  560642  XM_684037.5  XP_689129.4 
fruit fly
(Drosophila melanogaster)
Insecta ZnT35C6
CG318606
--
30(a)
21(a)
many ↔ many
many ↔ many
2L(15228728-15247832)
2L(12164241-12166704)
worm
(Caenorhabditis elegans)
Secernentea cdf-26
Protein CDF-2 (cdf-2) mRNA, complete cds
40(a)
1 → many
X(12464648-12466878) WBGene00011821
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZRC16
COT16
Vacuolar membrane zinc transporter, transports zin...
Vacuolar transporter that mediates zinc transport ...
19(a)
18(a)
many ↔ many
many ↔ many
XIII(754838-756166) YMR243C
XV(906236-907555) YOR316C


ENSEMBL Gene Tree for SLC30A8 (if available)
TreeFam Gene Tree for SLC30A8 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for SLC30A8 gene
SLC30A32  SLC30A22  SLC30A102  SLC30A12  SLC30A42  
4 SIMAP similar genes for SLC30A8 using alignment to 2 protein entries:     ZNT8_HUMAN (see all proteins):
ZNT4    SLC30A3    SLC30A4    SLC30A2

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot
ZNT8_HUMAN, Q8IWU4: Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus,
noninsulin-dependent (NIDDM) [MIM:125853]


Selected SNPs for SLC30A8 (see all 4558)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs132666341,2,,4
C,F,Hother1118455543(+) CCAGCC/TGGGAC 10 R W mis1 ese326Minor allele frequency- T:0.23EA NA NS WA EU 8495
rs1136096911,2
C--113294355(+) AAAAAG/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
rs1410791021,2
C--113353708(+) TACAA-/ATATATA 3 -- int10--------
rs347487481,2
C--113353709(+) ATATA-/AT/TA 
        
GATAT
3 -- int10--------
rs1996745901,2
C--113354241(+) CCCCCA/CCAAAA 3 -- int10--------
rs1493853151,2
C--113359236(+) TGGAT-/ATCATACA 3 -- cds10--------
rs1508560001,2
C--113359237(+) GGATA-/ATCTACAG 3 -- cds10--------
rs1139770421,2
C--113449198(+) TACTT-/AAAAAA 3 -- int11Minor allele frequency- A:0.50CSA 2
rs126744901,2
H--113505709(+) ttttGG/TCCAGC 5 -- int10--------
rs733102881,2
C,F--117961316(+) TCAGAG/ATTTCT 3 -- us2k13Minor allele frequency- A:0.15WA CSA 122

HapMap Linkage Disequilibrium report for SLC30A8 (117962512 - 118188953 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for SLC30A8:    About this table    
Variant IDTypeSubtypePubMed ID
dgv1303e199CNV Deletion23128226
esv2670074CNV Deletion23128226
nsv819890CNV Loss19587683
nsv527876CNV Loss19592680
nsv6360CNV Loss18451855
esv21665CNV Loss19812545
nsv891409CNV Loss21882294
nsv819760CNV Gain19587683
nsv831434CNV Gain17160897

Human Gene Mutation Database (HGMD): SLC30A8
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing SLC30A8
DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A8

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611145   
OMIM disorders: 125853  
2 diseases for SLC30A8:    
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diabetes mellitus, noninsulin-dependent    diabetes mellitus

1 disease from the University of Copenhagen DISEASES database for SLC30A8:
Diabetes mellitus

Find genes that share disorders with SLC30A8           About GenesLikeMe

1 Novoseek inferred disease relationship for SLC30A8 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
autoimmunity 46.8 2 19590848 (1), 19120306 (1)

Genetic Association Database (GAD): SLC30A8
Human Genome Epidemiology (HuGE) Navigator: SLC30A8 (112 documents)

Export disorders for SLC30A8 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for SLC30A8 gene, integrated from 10 sources (see all 177):
(articles sorted by number of sources associating them with SLC30A8)
    Utopia: connect your pdf to the dynamic
world of online information

  1. A genome-wide association study identifies novel risk loci for type 2 diabetes. (PubMed id 17293876)1, 2, 4 Sladek R....Froguel P. (Nature 2007)
  2. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. (PubMed id 18850084)1, 4, 9 Kawasaki E....Eguchi K. (Diabetologia 2008)
  3. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. (PubMed id 15331542)1, 2, 9 Chimienti F.... Seve M. (Diabetes 2004)
  4. ZnT-8, a pancreatic beta-cell-specific zinc transporter. (PubMed id 16158222)1, 2, 9 Chimienti F.... Seve M. (BioMetals 2005)
  5. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. (PubMed id 19590848)1, 4, 9 Achenbach P....Ziegler A.G. (Diabetologia 2009)
  6. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset. (PubMed id 18548167)1, 4, 9 Gohlke H....Ziegler A.G. (Rev Diabet Stud 2008)
  7. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. (PubMed id 16984975)1, 2, 9 Chimienti F....Seve M. (J. Cell Sci. 2006)
  8. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. (PubMed id 18324385)1, 4, 9 Boesgaard T.W....Hansen T. (Diabetologia 2008)
  9. Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. (PubMed id 20138556)1, 4, 9 Cauchi S....Marchetti P. (Mol. Genet. Metab. 2010)
  10. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. (PubMed id 21873549)1, 4 Strawbridge R.J....Florez J.C. (Diabetes 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 169026 HGNC: 20303 AceView: SLC30A8 Ensembl:ENSG00000164756 euGenes: HUgn169026
ECgene: SLC30A8 H-InvDB: SLC30A8

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for SLC30A8 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for SLC30A8 gene:
Search GeneIP for patents involving SLC30A8

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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