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Aliases for SLC30A8 Gene

Aliases for SLC30A8 Gene

  • Solute Carrier Family 30 Member 8 2 3 4
  • Solute Carrier Family 30 (Zinc Transporter), Member 8 2 3 5
  • ZnT-8 3 4
  • ZNT8 3 4
  • Zinc Transporter ZnT-8 3

External Ids for SLC30A8 Gene

Previous GeneCards Identifiers for SLC30A8 Gene

  • GC08P118024
  • GC08P117632
  • GC08P118104
  • GC08P118032
  • GC08P118216
  • GC08P117963
  • GC08P113288

Summaries for SLC30A8 Gene

Entrez Gene Summary for SLC30A8 Gene

  • The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

GeneCards Summary for SLC30A8 Gene

SLC30A8 (Solute Carrier Family 30 Member 8) is a Protein Coding gene. Diseases associated with SLC30A8 include Diabetes Mellitus, Noninsulin-Dependent and Prediabetes Syndrome. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include protein homodimerization activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A8 Gene

  • Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.

Gene Wiki entry for SLC30A8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A8 Gene

Genomics for SLC30A8 Gene

Regulatory Elements for SLC30A8 Gene

Enhancers for SLC30A8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC30A8 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A8 Gene

Chromosome:
8
Start:
116,950,180 bp from pter
End:
117,176,714 bp from pter
Size:
226,535 bases
Orientation:
Plus strand

Genomic View for SLC30A8 Gene

Genes around SLC30A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A8 Gene

Proteins for SLC30A8 Gene

  • Protein details for SLC30A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWU4-ZNT8_HUMAN
    Recommended name:
    Zinc transporter 8
    Protein Accession:
    Q8IWU4
    Secondary Accessions:
    • A0AVP9
    • A5YM39
    • B4DPE0
    • Q8TCL3

    Protein attributes for SLC30A8 Gene

    Size:
    369 amino acids
    Molecular mass:
    40755 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for SLC30A8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A8 Gene

Proteomics data for SLC30A8 Gene at MOPED

Post-translational modifications for SLC30A8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC30A8

No data available for DME Specific Peptides for SLC30A8 Gene

Domains & Families for SLC30A8 Gene

Gene Families for SLC30A8 Gene

Protein Domains for SLC30A8 Gene

Suggested Antigen Peptide Sequences for SLC30A8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWU4

UniProtKB/Swiss-Prot:

ZNT8_HUMAN :
  • Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Domain:
  • Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A8: view

Function for SLC30A8 Gene

Molecular function for SLC30A8 Gene

UniProtKB/Swiss-Prot Function:
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
genes like me logo Genes that share phenotypes with SLC30A8: view

Animal Models for SLC30A8 Gene

MGI Knock Outs for SLC30A8:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A8

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SLC30A8 Gene

Localization for SLC30A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A8 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A8 Gene COMPARTMENTS Subcellular localization image for SLC30A8 gene
Compartment Confidence
plasma membrane 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 15331542
GO:0030658 transport vesicle membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with SLC30A8: view

Pathways & Interactions for SLC30A8 Gene

genes like me logo Genes that share pathways with SLC30A8: view

Interacting Proteins for SLC30A8 Gene

Gene Ontology (GO) - Biological Process for SLC30A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009749 response to glucose IMP 16984975
GO:0010043 response to zinc ion IBA --
GO:0030073 insulin secretion IMP 16984975
GO:0032024 positive regulation of insulin secretion ISS --
GO:0032119 sequestering of zinc ion IDA 15331542
genes like me logo Genes that share ontologies with SLC30A8: view

No data available for SIGNOR curated interactions for SLC30A8 Gene

Drugs & Compounds for SLC30A8 Gene

(4) Drugs for SLC30A8 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Repaglinide Approved, Investigational Pharma Kir6 (KATP) channel blocker 51
insulin recombinant Pharma 0
zinc acetate Pharma 0
genes like me logo Genes that share compounds with SLC30A8: view

Transcripts for SLC30A8 Gene

Unigene Clusters for SLC30A8 Gene

Solute carrier family 30 (zinc transporter), member 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A8 Gene

No ASD Table

Relevant External Links for SLC30A8 Gene

GeneLoc Exon Structure for
SLC30A8
ECgene alternative splicing isoforms for
SLC30A8

Expression for SLC30A8 Gene

mRNA expression in normal human tissues for SLC30A8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A8 Gene

This gene is overexpressed in Pancreas (x36.5).

Protein differential expression in normal tissues from HIPED for SLC30A8 Gene

This gene is overexpressed in Cerebrospinal fluid (57.3) and Pancreas (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC30A8 Gene



SOURCE GeneReport for Unigene cluster for SLC30A8 Gene Hs.532270

mRNA Expression by UniProt/SwissProt for SLC30A8 Gene

Q8IWU4-ZNT8_HUMAN
Tissue specificity: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
genes like me logo Genes that share expression patterns with SLC30A8: view

Protein tissue co-expression partners for SLC30A8 Gene

Primer Products

Orthologs for SLC30A8 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A8 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia SLC30A8 35
  • 88.35 (n)
  • 86.45 (a)
SLC30A8 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a8 35
  • 82.92 (n)
  • 80.93 (a)
Slc30a8 16
Slc30a8 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A8 35
  • 99.46 (n)
  • 98.92 (a)
SLC30A8 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a8 35
  • 81.52 (n)
  • 79.13 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves SLC30A8 35
  • 66.03 (n)
  • 61.81 (a)
SLC30A8 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A8 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a8 35
  • 63.31 (n)
  • 60.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.27513 35
zebrafish
(Danio rerio)
Actinopterygii LOC560642 35
  • 62.24 (n)
  • 57.23 (a)
slc30a8 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31860 36
  • 21 (a)
ManyToMany
ZnT35C 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdf-2 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 18 (a)
ManyToMany
ZRC1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for SLC30A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A8 Gene

ENSEMBL:
Gene Tree for SLC30A8 (if available)
TreeFam:
Gene Tree for SLC30A8 (if available)

Paralogs for SLC30A8 Gene

Paralogs for SLC30A8 Gene

(4) SIMAP similar genes for SLC30A8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A8: view

Variants for SLC30A8 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A8 Gene

ZNT8_HUMAN-Q8IWU4
Variant Trp-325 is a risk factor that confers susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) [MIM:125853].

Sequence variations from dbSNP and Humsavar for SLC30A8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_031258 -
VAR_031259 -
rs2047962 -- 117,027,832(-) accct(C/T)ctttt intron-variant
rs2047963 -- 117,004,604(+) CTTCA(C/T)GGTAT intron-variant
rs2047964 -- 117,002,437(+) CTAAC(A/G)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A8 Gene

Variant ID Type Subtype PubMed ID
nsv831434 CNV Gain 17160897
nsv891409 CNV Loss 21882294
esv2670074 CNV Deletion 23128226
nsv6360 CNV Loss 18451855
dgv1303e199 CNV Deletion 23128226
esv21665 CNV Loss 19812545
nsv527876 CNV Loss 19592680
nsv819760 CNV Gain 19587683
nsv819890 CNV Loss 19587683

Variation tolerance for SLC30A8 Gene

Residual Variation Intolerance Score: 79.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A8 Gene

Human Gene Mutation Database (HGMD)
SLC30A8

Disorders for SLC30A8 Gene

MalaCards: The human disease database

(4) MalaCards diseases for SLC30A8 Gene - From: OMIM, ClinVar, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
prediabetes syndrome
  • prediabetes
glucose metabolism disease
  • disorder of glucose metabolism
diabetes mellitus, insulin-dependent
  • diabetes, type 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC30A8

Genetic Association Database (GAD)
SLC30A8
Human Genome Epidemiology (HuGE) Navigator
SLC30A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A8
genes like me logo Genes that share disorders with SLC30A8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A8 Gene

Publications for SLC30A8 Gene

  1. A genome-wide association study identifies novel risk loci for type 2 diabetes. (PMID: 17293876) Sladek R. … Froguel P. (Nature 2007) 3 4 48 67
  2. Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. (PMID: 20138556) Cauchi S. … Marchetti P. (Mol. Genet. Metab. 2010) 3 23
  3. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. (PMID: 19590848) Achenbach P. … Ziegler A.G. (Diabetologia 2009) 3 23
  4. Zn(2+)-transporter-8: a dual role in diabetes. (PMID: 19655390) Chistiakov D.A. … Voronova N.V. (Biofactors 2009) 3 23
  5. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients--the EUGENE2 study. (PMID: 18324385) Boesgaard T.W. … Hansen T. (Diabetologia 2008) 3 23

Products for SLC30A8 Gene

Sources for SLC30A8 Gene

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