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Aliases for SLC30A7 Gene

Aliases for SLC30A7 Gene

  • Solute Carrier Family 30 Member 7 2 3 4
  • Solute Carrier Family 30 (Zinc Transporter), Member 7 2 3 5
  • Znt-Like Transporter 2 3 4
  • ZnTL2 3 4
  • ZnT-7 3 4
  • ZNT7 3 4
  • Zinc Transporter Like 2 3
  • Zinc Transporter ZnT-7 3

External Ids for SLC30A7 Gene

Previous GeneCards Identifiers for SLC30A7 Gene

  • GC01P100542
  • GC01P100652
  • GC01P101073
  • GC01P101134
  • GC01P101361
  • GC01P099486

Summaries for SLC30A7 Gene

Entrez Gene Summary for SLC30A7 Gene

  • Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A7 Gene

SLC30A7 (Solute Carrier Family 30 Member 7) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A6.

UniProtKB/Swiss-Prot for SLC30A7 Gene

  • Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).

Gene Wiki entry for SLC30A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A7 Gene

Genomics for SLC30A7 Gene

Regulatory Elements for SLC30A7 Gene

Genomic Location for SLC30A7 Gene

Chromosome:
1
Start:
100,896,073 bp from pter
End:
100,996,913 bp from pter
Size:
100,841 bases
Orientation:
Plus strand

Genomic View for SLC30A7 Gene

Genes around SLC30A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A7 Gene

Proteins for SLC30A7 Gene

  • Protein details for SLC30A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEW0-ZNT7_HUMAN
    Recommended name:
    Zinc transporter 7
    Protein Accession:
    Q8NEW0
    Secondary Accessions:
    • B2R949
    • D3DT61
    • Q8TCH2

    Protein attributes for SLC30A7 Gene

    Size:
    376 amino acids
    Molecular mass:
    41626 Da
    Quaternary structure:
    • Homooligomer.

neXtProt entry for SLC30A7 Gene

Proteomics data for SLC30A7 Gene at MOPED

Post-translational modifications for SLC30A7 Gene

  • Ubiquitination at Lys 15
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A7 Gene

No data available for DME Specific Peptides for SLC30A7 Gene

Domains & Families for SLC30A7 Gene

Gene Families for SLC30A7 Gene

Protein Domains for SLC30A7 Gene

Suggested Antigen Peptide Sequences for SLC30A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEW0

UniProtKB/Swiss-Prot:

ZNT7_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A7: view

Function for SLC30A7 Gene

Molecular function for SLC30A7 Gene

UniProtKB/Swiss-Prot Function:
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
UniProtKB/Swiss-Prot Induction:
Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.
genes like me logo Genes that share phenotypes with SLC30A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A7

CRISPR Products

miRNA for SLC30A7 Gene

miRTarBase miRNAs that target SLC30A7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A7 Gene

Localization for SLC30A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A7 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A7 Gene COMPARTMENTS Subcellular localization image for SLC30A7 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with SLC30A7: view

Pathways & Interactions for SLC30A7 Gene

genes like me logo Genes that share pathways with SLC30A7: view

Gene Ontology (GO) - Biological Process for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport IEA --
GO:0010043 response to zinc ion IBA --
GO:0044267 cellular protein metabolic process TAS --
GO:0071577 zinc II ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC30A7: view

No data available for SIGNOR curated interactions for SLC30A7 Gene

Drugs & Compounds for SLC30A7 Gene

No Compound Related Data Available

Transcripts for SLC30A7 Gene

Unigene Clusters for SLC30A7 Gene

Solute carrier family 30 (zinc transporter), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A7 Gene

No ASD Table

Relevant External Links for SLC30A7 Gene

GeneLoc Exon Structure for
SLC30A7
ECgene alternative splicing isoforms for
SLC30A7

Expression for SLC30A7 Gene

mRNA expression in normal human tissues for SLC30A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC30A7 Gene

This gene is overexpressed in Nasal epithelium (23.8), Breast (14.1), and Serum (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A7 Gene



SOURCE GeneReport for Unigene cluster for SLC30A7 Gene Hs.533903

genes like me logo Genes that share expression patterns with SLC30A7: view

Protein tissue co-expression partners for SLC30A7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for SLC30A7 Gene

Orthologs for SLC30A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A7 35
  • 94.06 (n)
  • 97.61 (a)
SLC30A7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A7 35
  • 94.59 (n)
  • 97.61 (a)
SLC30A7 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a7 35
  • 89.98 (n)
  • 96.28 (a)
Slc30a7 16
Slc30a7 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A7 35
  • 99.38 (n)
  • 99.2 (a)
SLC30A7 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a7 35
  • 89.89 (n)
  • 95.74 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC30A7 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A7 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A7 35
  • 77.84 (n)
  • 83.24 (a)
SLC30A7 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A7 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76189 35
slc30a7 35
  • 72 (n)
  • 79.73 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a7 35
  • 69.06 (n)
  • 79.26 (a)
wufi11a08 35
slc30a7 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004461 35
  • 55.28 (n)
  • 58.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6672 35
  • 59.81 (n)
  • 63.14 (a)
CG6672 36
  • 60 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 36
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3181 35
Species with no ortholog for SLC30A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC30A7 Gene

ENSEMBL:
Gene Tree for SLC30A7 (if available)
TreeFam:
Gene Tree for SLC30A7 (if available)

Paralogs for SLC30A7 Gene

Paralogs for SLC30A7 Gene

(1) SIMAP similar genes for SLC30A7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A7: view

Variants for SLC30A7 Gene

Sequence variations from dbSNP and Humsavar for SLC30A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs15862 -- 100,981,121(+) ACTAG(C/T)GGGGa intron-variant, utr-variant-3-prime
rs1140055 -- 100,981,756(+) ATCTC(A/T)ACCTG intron-variant, downstream-variant-500B
rs1188737 -- 100,945,202(-) atcta(C/T)ccatc intron-variant
rs1408669 -- 100,979,453(-) ttttt(C/T)ttttt intron-variant, utr-variant-3-prime
rs1201404 -- 100,945,217(-) gagaa(A/C)atttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A7 Gene

Variant ID Type Subtype PubMed ID
nsv522064 CNV Gain 19592680
esv5152 CNV Deletion 18987735
esv2715407 CNV Deletion 23290073
esv2666592 CNV Deletion 23128226
esv1088978 CNV Insertion 17803354

Variation tolerance for SLC30A7 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A7 Gene

HapMap Linkage Disequilibrium report
SLC30A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A7 Gene

Disorders for SLC30A7 Gene

Relevant External Links for SLC30A7

Genetic Association Database (GAD)
SLC30A7
Human Genome Epidemiology (HuGE) Navigator
SLC30A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A7

No disorders were found for SLC30A7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A7 Gene

Publications for SLC30A7 Gene

  1. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. (PMID: 12446736) Kirschke C.P. … Huang L. (J. Biol. Chem. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (PMID: 23275032) Zhang X. … Ma J. (Cell. Signal. 2013) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3

Products for SLC30A7 Gene

Sources for SLC30A7 Gene

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