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Aliases for SLC30A7 Gene

Aliases for SLC30A7 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 7 2 3
  • ZNT7 3 4 6
  • Solute Carrier Family 30 Member 7 3 4
  • Znt-Like Transporter 2 3 4
  • ZnTL2 3 4
  • ZnT-7 3 4
  • Zinc Transporter Like 2 3
  • Zinc Transporter ZnT-7 3
  • Zinc Transporter 7 3

External Ids for SLC30A7 Gene

Summaries for SLC30A7 Gene

Entrez Gene Summary for SLC30A7 Gene

  • Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A7 Gene

SLC30A7 (Solute Carrier Family 30 (Zinc Transporter), Member 7) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A6.

UniProtKB/Swiss-Prot for SLC30A7 Gene

  • Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).

Gene Wiki entry for SLC30A7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A7 Gene

Genomics for SLC30A7 Gene

Genomic Location for SLC30A7 Gene

Start:
100,896,076 bp from pter
End:
100,997,380 bp from pter
Size:
101,305 bases
Orientation:
Plus strand

Genomic View for SLC30A7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A7 Gene

Regulatory Elements for SLC30A7 Gene

Proteins for SLC30A7 Gene

  • Protein details for SLC30A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEW0-ZNT7_HUMAN
    Recommended name:
    Zinc transporter 7
    Protein Accession:
    Q8NEW0
    Secondary Accessions:
    • B2R949
    • D3DT61
    • Q8TCH2

    Protein attributes for SLC30A7 Gene

    Size:
    376 amino acids
    Molecular mass:
    41626 Da
    Quaternary structure:
    • Homooligomer

neXtProt entry for SLC30A7 Gene

Proteomics data for SLC30A7 Gene at MOPED

Post-translational modifications for SLC30A7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys15

Other Protein References for SLC30A7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A7 Gene

Domains for SLC30A7 Gene

Gene Families for SLC30A7 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A7 Gene

UniProtKB/Swiss-Prot:

ZNT7_HUMAN
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.:
    • Q8NEW0
genes like me logo Genes that share domains with SLC30A7: view

Function for SLC30A7 Gene

Molecular function for SLC30A7 Gene

UniProtKB/Swiss-Prot Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
UniProtKB/Swiss-Prot Induction: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.

Gene Ontology (GO) - Molecular Function for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC30A7: view
genes like me logo Genes that share phenotypes with SLC30A7: view

miRNA for SLC30A7 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A7 Gene

Localization for SLC30A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A7 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A7 Gene COMPARTMENTS Subcellular localization image for SLC30A7 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005737 cytoplasm IDA 17349999
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
genes like me logo Genes that share ontologies with SLC30A7: view

Pathways for SLC30A7 Gene

genes like me logo Genes that share pathways with SLC30A7: view

Gene Ontology (GO) - Biological Process for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006829 zinc II ion transport IEA --
GO:0032119 sequestering of zinc ion IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC30A7: view

Transcripts for SLC30A7 Gene

Unigene Clusters for SLC30A7 Gene

Solute carrier family 30 (zinc transporter), member 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A7 Gene

No ASD Table

Relevant External Links for SLC30A7 Gene

GeneLoc Exon Structure for
SLC30A7
ECgene alternative splicing isoforms for
SLC30A7

Expression for SLC30A7 Gene

mRNA expression in normal human tissues for SLC30A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A7 Gene

SOURCE GeneReport for Unigene cluster for SLC30A7 Gene Hs.533903

genes like me logo Genes that share expressions with SLC30A7: view

Orthologs for SLC30A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A7 36
  • 99.38 (n)
  • 99.2 (a)
SLC30A7 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A7 36
  • 94.06 (n)
  • 97.61 (a)
SLC30A7 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A7 36
  • 94.59 (n)
  • 97.61 (a)
SLC30A7 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a7 36
  • 89.98 (n)
  • 96.28 (a)
Slc30a7 16
Slc30a7 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A7 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A7 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a7 36
  • 89.89 (n)
  • 95.74 (a)
chicken
(Gallus gallus)
Aves SLC30A7 36
  • 77.84 (n)
  • 83.24 (a)
SLC30A7 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A7 37
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76189 36
slc30a7 36
  • 72 (n)
  • 79.73 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a7 36
  • 69.06 (n)
  • 79.26 (a)
slc30a7 37
  • 77 (a)
OneToOne
wufi11a08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004461 36
  • 55.28 (n)
  • 58.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6672 36
  • 59.81 (n)
  • 63.14 (a)
CG6672 37
  • 60 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 37
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3181 36
Species with no ortholog for SLC30A7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC30A7 Gene

ENSEMBL:
Gene Tree for SLC30A7 (if available)
TreeFam:
Gene Tree for SLC30A7 (if available)

Paralogs for SLC30A7 Gene

Paralogs for SLC30A7 Gene

Selected SIMAP similar genes for SLC30A7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A7: view

Variants for SLC30A7 Gene

Sequence variations from dbSNP and Humsavar for SLC30A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs15862 -- 100,981,121(+) ACTAG(C/T)GGGGa utr-variant-3-prime, intron-variant
rs1140055 -- 100,981,756(+) ATCTC(A/T)ACCTG splice-donor-variant, intron-variant
rs1188737 -- 100,945,202(-) atcta(C/T)ccatc intron-variant
rs1201404 -- 100,945,217(-) gagaa(A/C)atttt intron-variant
rs1211186 -- 100,944,850(-) ctcaa(A/G)gatct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A7 Gene

Variant ID Type Subtype PubMed ID
nsv522064 CNV Gain 19592680
esv5152 CNV Deletion 18987735
esv2715407 CNV Deletion 23290073
esv2666592 CNV Deletion 23128226
esv1088978 CNV Insertion 17803354

Relevant External Links for SLC30A7 Gene

HapMap Linkage Disequilibrium report
SLC30A7

Disorders for SLC30A7 Gene

Relevant External Links for SLC30A7

Genetic Association Database (GAD)
SLC30A7
Human Genome Epidemiology (HuGE) Navigator
SLC30A7
genes like me logo Genes that share disorders with SLC30A7: view

No data available for UniProtKB/Swiss-Prot for SLC30A7 Gene

Publications for SLC30A7 Gene

  1. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. (PMID: 12446736) Kirschke C.P. … Huang L. (J. Biol. Chem. 2003) 2 3 4
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  3. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. (PMID: 15276077) Devergnas S. … Seve M. (Biochem. Pharmacol. 2004) 3 4
  4. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) . … Compston A. (Nature 2011) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SLC30A7 Gene

Sources for SLC30A7 Gene

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