SLC30A7 Gene
protein-coding GIFtS: 49
GCID: GC01P101361
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solute carrier family 30 (zinc transporter), member 7
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Aliases
for SLC30A7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 30 (Zinc Transporter), Member 71 2 | | ZnT-72 3 | | ZNT71 2 3 5 | | Zinc Transporter 72 | | ZnTL21 2 | | Zinc Transporter Like 22 | | Solute Carrier Family 30 Member 72 3 | | Zinc Transporter ZnT-72 | | Znt-Like Transporter 22 3 | | ZNTL23 |
Export aliases for SLC30A7 gene to outside databasesPrevious GC identifers: GC01P100542 GC01P100652 GC01P100824 GC01P101073 GC01P101134 GC01P099486 |
Summaries
for SLC30A7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC30A7:
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellularsignal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such asSLC30A7, permit cellular efflux of zinc (Seve et al., 2004 (PubMed 15154973)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: ZNT7_HUMAN, Q8NEW0Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellularzinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs).Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus,converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity)
Gene Wiki entry for SLC30A7
|
Genomic Views
for SLC30A7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC30A7 gene promoter:
RFX1 FOXJ2 (long isoform) FOXJ2 STAT5A c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC30A7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p21.2 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p21.1SLC30A7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P101361: view genomic region
(about GC identifiers)
Start:
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101,361,632 bp from pter |
End:
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101,447,311 bp from pter |
Size:
|
85,680 bases |
Orientation:
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plus strand |
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Proteins
for SLC30A7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ZNT7_HUMAN, Q8NEW0 (See
protein sequence)Recommended Name: Zinc transporter 7 Size: 376 amino acids; 41626 Da
Subunit: Homooligomer
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein
Secondary accessions: B2R949 D3DT61 Q8TCH2Explore the universe of human proteins at neXtProt for SLC30A7: NX_Q8NEW0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NEW0
SLC30A7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001138356.1 NP_598003.2
ENSEMBL proteins: ENSP00000359130 ENSP00000350278 ENSP00000359129 Reactome Protein details: Q8NEW0
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
SLC30A7 for ontologies About GeneDecksing
SLC30A7 Antibody Products:
Assay Products for SLC30A7: |
Protein
Domains /
Families
for SLC30A7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC30A7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NEW0ProtoNet protein and cluster: Q8NEW0 1 Blocks protein family: IPB002524 Cation efflux protein
UniProtKB/Swiss-Prot: ZNT7_HUMAN, Q8NEW0Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily |
Function
for SLC30A7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ZNT7_HUMAN, Q8NEW0Function: Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellularzinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs).Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus,converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity)Induction: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up-or down-regulation of gene expression. Up-regulated by zinc depletion
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A7 (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A7 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008324 | cation transmembrane transporter activity |
IEA | -- |
SLC30A7 for ontologies About GeneDecksing
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Slc30a7):
SLC30A7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for SLC30A7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Zinc transporters | | | 2 | SLC-mediated transmembrane transport | | | 3 | Insulin Processing | | | 4 | Asparagine N-linked glycosylation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 
Reactome Pathways for SLC30A7 (see all 10)
SLC30A7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC30A7
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for SLC30A7 (Q8NEW01, 3 ENSP000003502784) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006829 | zinc ion transport |
IEA | -- | | GO:0032119 | sequestering of zinc ion |
IEA | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
SLC30A7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC30A7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC30A7
Search CenterWatch for drugs/clinical trials and news about SLC30A7 / ZNT7
|
Transcripts
for SLC30A7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC30A7 gene (2 alternative transcripts): NM_001144884.1 NM_133496.4 Unigene Cluster for SLC30A7: Solute carrier family 30 (zinc transporter), member 7 Hs.533903 [show with all ESTs]Unigene Representative Sequence: NM_1334963 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000370112(uc001dtn.2 uc001dto.2) ENST00000357650 ENST00000370111
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A7 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A7 (NM_133496) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC30A7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A7 |
Additional cDNA sequence: AF233345.1 AF529197.1 AK023089.1 AK313638.1 AY094606.1 BC064692.1 BX537375.1 BX640630.1 BX648884.1 CR936806.1 9 DOTS entries: DT.97836395 DT.101982541 DT.121442662 DT.95361141 DT.121442667 DT.121442793 DT.75125997 DT.91803880 DT.101959703 24/156 AceView cDNA sequences (see all 156): BX648884 BQ024227 BC064692 AA884217 AW083910 CD723947 AA654646 BF435410 AA604742 AA311915 AL700318 AA136532 BM717753 BU682542 CB989038 BQ953816 NM_133496 BM142196 AI189239 AU130540 AI913377 BF434559 BM674946 AI742593
GeneLoc Exon Structure
|
Expression
for SLC30A7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC30A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See SLC30A7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC30A7
SOURCE GeneReport for Unigene cluster: Hs.533903
SABiosciences Custom PCR Arrays for SLC30A7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC30A7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC30A7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A7 |
Orthologs
for SLC30A7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC30A7 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for SLC30A7 (if available)
TreeFam Gene Tree for SLC30A7 (if available) |
Paralogs
for SLC30A7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC30A7 gene
- SLC30A52 SLC30A62
1 SIMAP similar gene for SLC30A7 using alignment to 2 protein entries: ZNT7_HUMAN (see all proteins):SLC30A5
SLC30A7 for paralogs About GeneDecksing
|
Genomic Variants
for SLC30A7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC30A7 (101361632 - 101447311 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for SLC30A7
2 Indels: 39639 42227 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC30A7 |
|
Disorders
/ Diseases
for SLC30A7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC30A7 for disorders About GeneDecksing
OMIM gene information: 611149
OMIM disorders: --
6  diseases for SLC30A7: About MalaCardsacrodermatitis enteropathica enteropathica acrodermatitis alzheimer's disease
pneumonia prostatitis
Human Genome Epidemiology (HuGE) Navigator: SLC30A7 (1 document)
Export disorders for SLC30A7 gene to outside databases
|
Publications
for SLC30A7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC30A7 gene, integrated from 9 sources (see all 28):
(articles sorted by number of sources associating them with SLC30A7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. (PubMed id 12446736)1, 2, 3 Kirschke C.P. and Huang L. (2003)
- Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. (PubMed id 15276077)1, 2 Devergnas S.... Seve M. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Genetic risk and a primary role for cell-mediated immu ne mechanisms in multiple sclerosis. (PubMed id 21833088)1 ....Compston A. (2011)
- Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Gastrointestinal factors influencing zinc absorption and homeostasis. (PubMed id 21462106)1 Cousins R.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
|
External Searches for SLC30A7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing SLC30A7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC30A7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC30A7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC30A7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for SLC30A7 gene:
Search GeneIP for patents involving SLC30A7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC30A7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A7 |
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