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Aliases for SLC30A7 Gene

Aliases for SLC30A7 Gene

  • Solute Carrier Family 30 Member 7 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 7 2 3
  • Znt-Like Transporter 2 3 4
  • ZnTL2 3 4
  • ZnT-7 3 4
  • ZNT7 3 4
  • Zinc Transporter Like 2 3
  • Zinc Transporter ZnT-7 3
  • Zinc Transporter 7 3

External Ids for SLC30A7 Gene

Previous GeneCards Identifiers for SLC30A7 Gene

  • GC01P100542
  • GC01P100652
  • GC01P101073
  • GC01P101134
  • GC01P101361
  • GC01P099486

Summaries for SLC30A7 Gene

Entrez Gene Summary for SLC30A7 Gene

  • Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A7 Gene

SLC30A7 (Solute Carrier Family 30 Member 7) is a Protein Coding gene. Diseases associated with SLC30A7 include Joubert Syndrome 1. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A5.

UniProtKB/Swiss-Prot for SLC30A7 Gene

  • Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).

Gene Wiki entry for SLC30A7 Gene

Additional gene information for SLC30A7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A7 Gene

Genomics for SLC30A7 Gene

Regulatory Elements for SLC30A7 Gene

Enhancers for SLC30A7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H100348 1.7 FANTOM5 ENCODE dbSUPER 39.6 -543.8 -543840 7 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 MFSD14A BRI3P1 SLC30A7 SASS6 CDC14A TRMT13 HNRNPA1P68 ENSG00000235795 LOC646970 ENSG00000226952
GH01H101257 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18 +365.6 365573 9 PKNOX1 FOXA2 YBX1 FEZF1 ZNF2 YY1 ZNF766 SP5 REST SREBF1 SLC30A7 HNRNPA1P68 ENSG00000235795 ENSG00000252765 DPH5 LOC102606465 GC01M101263 RPS20P6
GH01H100362 1.6 FANTOM5 ENCODE dbSUPER 21.1 -533.0 -533011 0 HDAC1 HNRNPUL1 TBP HDGF PKNOX1 ATF1 TBL1XR1 ARNT NFRKB DEAF1 MFSD14A BRI3P1 SLC30A7 HNRNPA1P68 CDC14A MIR553 SASS6 BCAS2P2
GH01H100394 1.3 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -499.4 -499449 5 HDGF SMARCA4 ZNF266 ATF2 CDC14A SLC30A7 HNRNPA1P68 MFSD14A ENSG00000235795 BRI3P1 SASS6 TRMT13 GPR88 BCAS2P2
GH01H100924 1.1 FANTOM5 ENCODE dbSUPER 18 +30.6 30638 4 CTCF ZNF680 RUNX3 SLC30A7 EXTL2 ENSG00000252765 DPH5 LOC102606465 S1PR1 HNRNPA1P68
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC30A7 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A7 Gene

Chromosome:
1
Start:
100,896,073 bp from pter
End:
100,996,913 bp from pter
Size:
100,841 bases
Orientation:
Plus strand

Genomic View for SLC30A7 Gene

Genes around SLC30A7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A7 Gene

Proteins for SLC30A7 Gene

  • Protein details for SLC30A7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NEW0-ZNT7_HUMAN
    Recommended name:
    Zinc transporter 7
    Protein Accession:
    Q8NEW0
    Secondary Accessions:
    • B2R949
    • D3DT61
    • Q8TCH2

    Protein attributes for SLC30A7 Gene

    Size:
    376 amino acids
    Molecular mass:
    41626 Da
    Quaternary structure:
    • Homooligomer.

neXtProt entry for SLC30A7 Gene

Post-translational modifications for SLC30A7 Gene

  • Ubiquitination at isoforms=15
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A7 Gene

No data available for DME Specific Peptides for SLC30A7 Gene

Domains & Families for SLC30A7 Gene

Gene Families for SLC30A7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC30A7 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC30A7 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NEW0

UniProtKB/Swiss-Prot:

ZNT7_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A7: view

Function for SLC30A7 Gene

Molecular function for SLC30A7 Gene

UniProtKB/Swiss-Prot Function:
Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP (By similarity).
UniProtKB/Swiss-Prot Induction:
Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.

Phenotypes From GWAS Catalog for SLC30A7 Gene

Gene Ontology (GO) - Molecular Function for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IBA --
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC30A7: view
genes like me logo Genes that share phenotypes with SLC30A7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A7

CRISPR Products

miRNA for SLC30A7 Gene

miRTarBase miRNAs that target SLC30A7

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC30A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A7 Gene

Localization for SLC30A7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A7 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC30A7 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005794 Golgi apparatus IEA,IDA 17349999
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with SLC30A7: view

Pathways & Interactions for SLC30A7 Gene

genes like me logo Genes that share pathways with SLC30A7: view

Pathways by source for SLC30A7 Gene

Gene Ontology (GO) - Biological Process for SLC30A7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0010043 response to zinc ion IBA --
genes like me logo Genes that share ontologies with SLC30A7: view

No data available for SIGNOR curated interactions for SLC30A7 Gene

Drugs & Compounds for SLC30A7 Gene

No Compound Related Data Available

Transcripts for SLC30A7 Gene

Unigene Clusters for SLC30A7 Gene

Solute carrier family 30 (zinc transporter), member 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC30A7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A7 Gene

No ASD Table

Relevant External Links for SLC30A7 Gene

GeneLoc Exon Structure for
SLC30A7
ECgene alternative splicing isoforms for
SLC30A7

Expression for SLC30A7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC30A7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC30A7 Gene

This gene is overexpressed in Nasal epithelium (23.8), Breast (14.1), and Serum (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC30A7 Gene



Protein tissue co-expression partners for SLC30A7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC30A7 Gene:

SLC30A7

SOURCE GeneReport for Unigene cluster for SLC30A7 Gene:

Hs.533903

Evidence on tissue expression from TISSUES for SLC30A7 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with SLC30A7: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC30A7 Gene

Orthologs for SLC30A7 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A7 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia SLC30A7 33 34
  • 94.59 (n)
cow
(Bos Taurus)
Mammalia SLC30A7 33 34
  • 94.06 (n)
mouse
(Mus musculus)
Mammalia Slc30a7 33 16 34
  • 89.98 (n)
rat
(Rattus norvegicus)
Mammalia Slc30a7 33
  • 89.89 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC30A7 34
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A7 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A7 33 34
  • 77.84 (n)
lizard
(Anolis carolinensis)
Reptilia SLC30A7 34
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a7 33
  • 72 (n)
MGC76189 33
zebrafish
(Danio rerio)
Actinopterygii slc30a7 33 34
  • 69.06 (n)
wufi11a08 33
fruit fly
(Drosophila melanogaster)
Insecta CG6672 33 34
  • 59.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004461 33
  • 55.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 34
  • 14 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3181 33
Species where no ortholog for SLC30A7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC30A7 Gene

ENSEMBL:
Gene Tree for SLC30A7 (if available)
TreeFam:
Gene Tree for SLC30A7 (if available)

Paralogs for SLC30A7 Gene

Paralogs for SLC30A7 Gene

(1) SIMAP similar genes for SLC30A7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A7: view

Variants for SLC30A7 Gene

Sequence variations from dbSNP and Humsavar for SLC30A7 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000000812 -- 100,996,675(+) GGCAA(C/T)GTAAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000061912 -- 100,914,307(+) AACTA(A/T)TTTTT intron-variant
rs1000065415 -- 100,896,758(+) TCACT(A/G)GGAGG intron-variant, upstream-variant-2KB
rs1000069602 -- 100,942,869(+) GAGAA(C/T)GGGGC intron-variant
rs1000100145 -- 100,943,311(+) CTAGC(A/G)TATTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A7 Gene

Variant ID Type Subtype PubMed ID
esv1088978 CNV insertion 17803354
esv2666592 CNV deletion 23128226
esv2715407 CNV deletion 23290073
esv3566537 CNV deletion 23714750
esv3578026 CNV loss 25503493
esv5152 CNV loss 18987735
nsv1149468 CNV insertion 26484159
nsv1152359 CNV deletion 26484159
nsv522064 CNV gain 19592680
nsv946098 CNV duplication 23825009

Variation tolerance for SLC30A7 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.16; 23.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A7 Gene

Human Gene Mutation Database (HGMD)
SLC30A7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC30A7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A7 Gene

Disorders for SLC30A7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC30A7 Gene - From: ClinVar

Disorder Aliases PubMed IDs
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC30A7

Genetic Association Database (GAD)
SLC30A7
Human Genome Epidemiology (HuGE) Navigator
SLC30A7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A7
genes like me logo Genes that share disorders with SLC30A7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A7 Gene

Publications for SLC30A7 Gene

  1. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. (PMID: 12446736) Kirschke CP … Huang L (The Journal of biological chemistry 2003) 2 3 4 60
  2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. (PMID: 21833088) International Multiple Sclerosis Genetics Consortium … Compston A (Nature 2011) 3 45 60
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L … Thibodeau SN (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2008) 3 45 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. (PMID: 15276077) Devergnas S … Seve M (Biochemical pharmacology 2004) 3 4 60

Products for SLC30A7 Gene

Sources for SLC30A7 Gene

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