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Aliases for SLC30A6 Gene

Aliases for SLC30A6 Gene

  • Solute Carrier Family 30 Member 6 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 6 2 3
  • ZNT6 3 4
  • Zinc Transporter 6 3
  • MSTP103 3
  • MST103 3
  • ZnT-6 4

External Ids for SLC30A6 Gene

Previous GeneCards Identifiers for SLC30A6 Gene

  • GC02P032518
  • GC02P032348
  • GC02P032365
  • GC02P032302
  • GC02P032244
  • GC02P032390
  • GC02P032130

Summaries for SLC30A6 Gene

Entrez Gene Summary for SLC30A6 Gene

  • This gene encodes a member of a family of proteins that function as zinc transporters. This protein can regulate subcellular levels of zinc in the Golgi and vesicles. Expression of this gene is altered in the Alzheimer's disease brain plaques. [provided by RefSeq, Aug 2016]

GeneCards Summary for SLC30A6 Gene

SLC30A6 (Solute Carrier Family 30 Member 6) is a Protein Coding gene. Diseases associated with SLC30A6 include X-Linked Hereditary Ataxia and Fragile X-Associated Tremor/Ataxia Syndrome. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A5.

UniProtKB/Swiss-Prot for SLC30A6 Gene

  • Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A6 Gene

Genomics for SLC30A6 Gene

Regulatory Elements for SLC30A6 Gene

Enhancers for SLC30A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F032135 1 Ensembl ENCODE 18.9 -30.0 -29988 1.7 CTCF ZNF146 JUN RAD21 POLR3A EED SMC3 FOS FOSL2 CEBPB SLC30A6 RNU6-647P DPY30 MEMO1 GC02M032061 GC02P032156
GH02F031987 1 Ensembl ENCODE 16.2 -178.0 -178041 1.6 CTCF SOX13 JUN CEBPG ZNF366 NR2F6 HOMEZ THAP11 GATAD2A SOX5 SLC30A6 MEMO1 DPY30 GC02P031938
GH02F031837 0.9 Ensembl 15.6 -328.3 -328341 0.2 ELF3 HDAC1 ZBTB40 RAD21 ZNF366 ZBTB2 CEBPB ELF1 NFIL3 MIER3 SLC30A6 LINC01946 AK2P2 ENSG00000273165
GH02F032164 1.2 ENCODE 10.7 +0.5 467 3.7 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 BIRC6 TTC27 DDX50P1 SLC30A6 RNU6-647P ENSG00000272716 NLRC4
GH02F032277 1.1 ENCODE 10.5 +112.2 112208 2.0 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 FOS SP3 NFYC BIRC6 TTC27 DDX50P1 RNU6-647P SLC30A6 SPAST NLRC4 YIPF4 ENSG00000272754
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC30A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC30A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for SLC30A6 Gene

32,165,841 bp from pter
32,224,379 bp from pter
58,539 bases
Plus strand

Genomic View for SLC30A6 Gene

Genes around SLC30A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A6 Gene

Proteins for SLC30A6 Gene

  • Protein details for SLC30A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter 6
    Protein Accession:
    Secondary Accessions:
    • A5YM45
    • B7Z901
    • Q8N5C9
    • Q96NC3

    Protein attributes for SLC30A6 Gene

    461 amino acids
    Molecular mass:
    51116 Da
    Quaternary structure:
    • Heterooligomer. Interacts with ZNT5 (By similarity).
    • Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5.
    • Sequence=AAH32525.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC30A6 Gene


neXtProt entry for SLC30A6 Gene

Post-translational modifications for SLC30A6 Gene

  • Ubiquitination at Lys 268
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC30A6 Gene

Domains & Families for SLC30A6 Gene

Gene Families for SLC30A6 Gene

Protein Domains for SLC30A6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A6: view

Function for SLC30A6 Gene

Molecular function for SLC30A6 Gene

UniProtKB/Swiss-Prot Function:
Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

Gene Ontology (GO) - Molecular Function for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC30A6: view

Phenotypes for SLC30A6 Gene

genes like me logo Genes that share phenotypes with SLC30A6: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A6 Gene

Localization for SLC30A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A6 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC30A6 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005794 Golgi apparatus IDA 17349999
GO:0016020 membrane IEA,IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A6: view

Pathways & Interactions for SLC30A6 Gene

genes like me logo Genes that share pathways with SLC30A6: view

Interacting Proteins for SLC30A6 Gene

Gene Ontology (GO) - Biological Process for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0010043 response to zinc ion IBA --
genes like me logo Genes that share ontologies with SLC30A6: view

No data available for SIGNOR curated interactions for SLC30A6 Gene

Transcripts for SLC30A6 Gene

Unigene Clusters for SLC30A6 Gene

Solute carrier family 30 (zinc transporter), member 6:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A6 Gene

No ASD Table

Relevant External Links for SLC30A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC30A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC30A6 Gene

Protein differential expression in normal tissues from HIPED for SLC30A6 Gene

This gene is overexpressed in Fetal Liver (45.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC30A6 Gene

Protein tissue co-expression partners for SLC30A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC30A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC30A6 Gene:


mRNA Expression by UniProt/SwissProt for SLC30A6 Gene:

Tissue specificity: Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.
genes like me logo Genes that share expression patterns with SLC30A6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC30A6 Gene

Orthologs for SLC30A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC30A6 34 35
  • 99.49 (n)
(Bos Taurus)
Mammalia SLC30A6 34 35
  • 93.42 (n)
(Canis familiaris)
Mammalia SLC30A6 34 35
  • 93.13 (n)
(Monodelphis domestica)
Mammalia SLC30A6 35
  • 88 (a)
(Rattus norvegicus)
Mammalia Slc30a6 34
  • 87.03 (n)
(Mus musculus)
Mammalia Slc30a6 34 16 35
  • 86.3 (n)
(Ornithorhynchus anatinus)
Mammalia SLC30A6 35
  • 84 (a)
(Gallus gallus)
Aves SLC30A6 34 35
  • 80.29 (n)
(Anolis carolinensis)
Reptilia SLC30A6 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a6 34
  • 76.47 (n)
Str.5891 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.4176 34
(Danio rerio)
Actinopterygii slc30a6 35
  • 18 (a)
Dr.28601 34
(Caenorhabditis elegans)
Secernentea toc-1 35
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 35
  • 8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5211 35
  • 34 (a)
Species where no ortholog for SLC30A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A6 Gene

Gene Tree for SLC30A6 (if available)
Gene Tree for SLC30A6 (if available)

Paralogs for SLC30A6 Gene

Paralogs for SLC30A6 Gene

(1) SIMAP similar genes for SLC30A6 Gene using alignment to 7 proteins: Pseudogenes for SLC30A6 Gene

genes like me logo Genes that share paralogs with SLC30A6: view

Variants for SLC30A6 Gene

Sequence variations from dbSNP and Humsavar for SLC30A6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10172468 -- 32,207,128(+) AATCA(A/C)ATTCA intron-variant
rs10194703 -- 32,194,934(+) CCTGT(A/T)AAGAT intron-variant
rs10199511 -- 32,183,938(+) TTTTA(A/G)CATTT intron-variant
rs10522618 -- 32,212,913(+) TTTTT(-/TTTTTTTTT)AAGGA intron-variant
rs10681739 -- 32,215,517(+) TATAT(-/A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A6 Gene

Variant ID Type Subtype PubMed ID
esv2422335 CNV duplication 17116639
esv2719876 CNV deletion 23290073
esv2719877 CNV deletion 23290073
esv3590242 CNV gain 21293372
esv3590243 CNV gain 21293372
nsv2667 CNV deletion 18451855
nsv833670 CNV loss 17160897
nsv978991 CNV duplication 23825009

Variation tolerance for SLC30A6 Gene

Residual Variation Intolerance Score: 51.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A6 Gene

Disorders for SLC30A6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC30A6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
x-linked hereditary ataxia
fragile x-associated tremor/ataxia syndrome
  • fragile x tremor/ataxia syndrome
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC30A6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC30A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A6 Gene

Publications for SLC30A6 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 46 64
  3. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. (PMID: 16580781) Smith J.L. … Lovell M.A. (Neuroscience 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PMID: 15154973) Seve M. … Favier A. (BMC Genomics 2004) 3 4 64

Products for SLC30A6 Gene

Sources for SLC30A6 Gene

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