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SLC30A6 Gene

protein-coding   GIFtS: 52
GCID: GC02P032390

Solute Carrier Family 30 (Zinc Transporter), Member 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 61 2     MSTP1032
ZNT62 3 5     Zinc Transporter 62
Solute Carrier Family 30 Member 62 3     znT-62
MST1032     ZnT-63

External Ids:    HGNC: 193051   Entrez Gene: 556762   Ensembl: ENSG000001526837   OMIM: 6111485   UniProtKB: Q6NXT43   

Export aliases for SLC30A6 gene to outside databases

Previous GC identifers: GC02P032518 GC02P032348 GC02P032365 GC02P032302 GC02P032244 GC02P032130


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC30A6 Gene:
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and
intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion
facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 (PubMed
15154973)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC30A6 Gene:
SLC30A6 (solute carrier family 30 (zinc transporter), member 6) is a protein-coding gene. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A5.

UniProtKB/Swiss-Prot: ZNT6_HUMAN, Q6NXT4
Function: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as
the vesicular compartment (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A6 gene promoter:
         AML1a   ATF-2   FOXO3   NF-AT   FOXO3b   c-Ets-1   NF-AT2   FOXC1   FOXO3a   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A6 promoter sequence
   Search Chromatin IP Primers for SLC30A6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.3   Ensembl cytogenetic band:  2p22.3   HGNC cytogenetic band: 2p22.3

SLC30A6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A6 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P032390:  view genomic region     (about GC identifiers)

Start:
32,390,910 bp from pter      End:
32,449,448 bp from pter
Size:
58,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNT6_HUMAN, Q6NXT4 (See protein sequence)
Recommended Name: Zinc transporter 6  
Size: 461 amino acids; 51116 Da
Subunit: Heterooligomer. Interacts with ZNT5 (By similarity)
Miscellaneous: Seems to have lost most of the histidine residues in the loop between the fourth and fifth
transmembrane regions and appears to exert transport function by forming complexes with ZNT5 (By similarity)
Sequence caution: Sequence=AAH32525.1; Type=Erroneous initiation;
Secondary accessions: A5YM45 B7Z901 Q8N5C9 Q96NC3
Alternative splicing: 4 isoforms:  Q6NXT4-1   Q6NXT4-2   Q6NXT4-4   Q6NXT4-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC30A6: NX_Q6NXT4

Explore proteomics data for SLC30A6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys268
  • Modification sites at PhosphoSitePlus

  • See SLC30A6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001180442.1  NP_001180443.1  NP_001180444.1  NP_060434.2  

    ENSEMBL proteins: 
     ENSP00000393946   ENSP00000368648   ENSP00000415790   ENSP00000388013   ENSP00000282587  
     ENSP00000384041   ENSP00000396634   ENSP00000399005   ENSP00000440678   ENSP00000349563  
    Reactome Protein details: Q6NXT4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 6
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q6NXT4

    ProtoNet protein and cluster: Q6NXT4

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT6_HUMAN, Q6NXT4
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    Find genes that share domains with SLC30A6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT6_HUMAN, Q6NXT4
    Function: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as
    the vesicular compartment (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0008324cation transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC30A6           About GenesLikeMe


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target SLC30A6:
    hsa-mir-423-3p (MIRT042568), hsa-let-7d-5p (MIRT032161), hsa-mir-196a-5p (MIRT026066)

    Block miRNA regulation of human, mouse, rat SLC30A6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC30A6 (see all 44):
    hsa-let-7d hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-3148 hsa-miR-98 hsa-miR-203 hsa-miR-433
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A6 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNT6_HUMAN, Q6NXT4: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in
    vesicles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus4
    plasma membrane3
    mitochondrion2
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005739mitochondrion IEA--
    GO:0005794Golgi apparatus IDA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC30A6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC30A6 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc transporters0.00
    Zinc efflux and compartmentalization by the SLC30 family0.00
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Insulin Processing0.30
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with SLC30A6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for SLC30A6
        Zinc efflux and compartmentalization by the SLC30 family
    Insulin processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC30A6
    Interactions:

        Search GeneGlobe Interaction Network for SLC30A6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for SLC30A6 (Q6NXT43 ENSP000002825874) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EGFRP005333I2D: score=1 
    PIGNENSP000003502634STRING: ENSP00000350263
    PISDENSP000002660954STRING: ENSP00000266095
    UBCENSP000003448184STRING: ENSP00000344818
    SIN3AENSP000003536224STRING: ENSP00000353622
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006829zinc ion transport ----
    GO:0006895Golgi to endosome transport IEA--
    GO:0044267cellular protein metabolic process TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC30A6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC30A6 (ZNT6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC30A6 gene (4 alternative transcripts): 
    NM_001193513.1  NM_001193514.1  NM_001193515.1  NM_017964.3  

    Unigene Cluster for SLC30A6:

    Solute carrier family 30 (zinc transporter), member 6
    Hs.23248  [show with all ESTs]
    Unigene Representative Sequence: NM_001193513
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000440718 ENST00000379343 ENST00000454324 ENST00000449777 ENST00000282587(uc002rof.2 uc002roe.2 uc010ymw.2 uc010ezr.2 uc002rog.2 uc010ezs.2 uc002roh.2)
    ENST00000406369 ENST00000457724 ENST00000435660 ENST00000538303 ENST00000357055

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    Selected qRT-PCR Assays for microRNAs that regulate SLC30A6 (see all 44):
    hsa-let-7d hsa-let-7g hsa-miR-4314 hsa-let-7a hsa-miR-3148 hsa-miR-98 hsa-miR-203 hsa-miR-433
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC30A6
      QuantiFast Probe-based Assays in human, mouse, rat SLC30A6

    Additional mRNA sequence: 

    AF173387.1 AK055663.1 AK096672.1 AK127716.1 AK304225.1 AL832755.1 BC032525.1 BC066903.1 
    EF560719.1 EF560726.1 

    13 DOTS entries:

    DT.92429178  DT.95211449  DT.100722718  DT.100720137  DT.40123654  DT.95088986  DT.101981936  DT.120988427 
    DT.91961317  DT.92050796  DT.97797646  DT.99984921  DT.95149730 

    Selected AceView cDNA sequences (see all 153):

    AI611796 AA724498 NM_017964 AL709308 BM128449 BM465456 F02603 AL703531 
    AK055663 BG528287 CR622136 AI093699 AI401266 BM741437 Z39262 AK096672 
    BF432561 AA609888 BE645035 BU166993 AK127716 AI159857 BG527678 BC032525 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC30A6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGAATTA
    SLC30A6 Expression
    About this image

    SLC30A6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC30A6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23248

    UniProtKB/Swiss-Prot: ZNT6_HUMAN, Q6NXT4
    Tissue specificity: Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and
    middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone,
    brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC30A6 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a61 , 5 solute carrier family 30 (zinc transporter), member more1, 5 86.3(n)1
    92.39(a)1
      17 (45.64 cM)5
    2101481  NM_144798.61  NP_659047.21 
     743956085 
    chicken
    (Gallus gallus)
    Aves SLC30A61 solute carrier family 30 (zinc transporter), member more 80.29(n)
    90.65(a)
      421480  NM_001006402.1  NP_001006402.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A66
    solute carrier family 30 (zinc transporter), membe...
    74(a)
    1 ↔ 1
    1(235399566-235422186)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.41762 Xenopus laevis transcribed sequence with weak similarity more 78.96(n)    BU914042.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.286012 Danio rerio cDNA clone IMAGE6797686, partial cds 70.87(n)    BC058300.1 
    worm
    (Caenorhabditis elegans)
    Secernentea toc-16
    Protein TOC-1, isoform a (toc-1) mRNA, complete cd...
    30(a)
    1 ↔ 1
    III(5275225-5277801) WBGene00006590
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSC26
    Member of the cation diffusion facilitator family,...
    8(a)
    1 → many
    IV(859346-861520) YDR205W


    ENSEMBL Gene Tree for SLC30A6 (if available)
    TreeFam Gene Tree for SLC30A6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC30A6 gene
    SLC30A52  SLC30A72  
    1 SIMAP similar gene for SLC30A6 using alignment to 7 protein entries:     ZNT6_HUMAN (see all proteins):
    MST103

    Find genes that share paralogs with SLC30A6           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for SLC30A6
    PGOHUM00000240259


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC30A6 (see all 1304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs728639371,2
    C--32388923(+) CCCGAA/GTAGCT 4 -- us2k12Minor allele frequency- G:0.33WA CSA 3
    rs12654221,2
    C,A,H--32388958(+) acccgA/Gctaag 4 -- us2k1 tfbs30--------
    rs116764751,2
    C,F,A,H--32389190(+) agcatC/Tttggg 4 -- us2k110Minor allele frequency- T:0.47NA WA CSA EA 371
    rs1402129001,2
    --32389296(+) TGCAGC/TGTGGA 4 -- us2k10--------
    rs1503120121,2
    C--32389297(+) GCAGTA/GTGGAG 4 -- us2k10--------
    rs714460541,2
    C,F--32389371(+) TTTGAG/AATGAA 4 -- us2k14Minor allele frequency- A:0.06NA WA 242
    rs1858671761,2
    --32389420(+) ATCTCA/C/GCCTCA 4 -- us2k10--------
    rs1906144401,2
    --32389444(+) CTCCCA/GGGTTC 4 -- us2k10--------
    rs1816839351,2
    --32389465(+) CCTGCC/GTCAGC 4 -- us2k10--------
    rs1872904691,2
    --32389528(+) TTTATC/TTTTAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC30A6 (32390910 - 32449448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC30A6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719877CNV Deletion23290073
    esv2719876CNV Deletion23290073
    esv2422335CNV Duplication17116639
    nsv873778CNV Loss21882294
    nsv2667CNV Loss18451855
    nsv833670CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611148    OMIM disorders: --


    Find genes that share disorders with SLC30A6           About GenesLikeMe

    Genetic Association Database (GAD): SLC30A6
    Human Genome Epidemiology (HuGE) Navigator: SLC30A6 (2 documents)

    Export disorders for SLC30A6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC30A6 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC30A6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    3. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. (PubMed id 16580781)1, 2 Smith J.L.... Lovell M.A. (Neuroscience 2006)
    4. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PubMed id 15154973)1, 2 Seve M.... Favier A. (BMC Genomics 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Zinc transporter mRNA levels in Alzheimer's disease postmortem brain. (PubMed id 22349685)1 Beyer N....Johnston J.A. (J. Alzheimers Dis. 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. (PubMed id 19371353)1 Lyubartseva G....Lovell M.A. (Brain Pathol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55676 HGNC: 19305 AceView: SLC30A6 Ensembl:ENSG00000152683 euGenes: HUgn55676
    ECgene: SLC30A6 H-InvDB: SLC30A6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC30A6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC30A6 gene:
    Search GeneIP for patents involving SLC30A6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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