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Aliases for SLC30A6 Gene

Aliases for SLC30A6 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 6 2 3
  • ZNT6 3 4 6
  • Solute Carrier Family 30 Member 6 3 4
  • ZnT-6 3 4
  • Zinc Transporter 6 3
  • MSTP103 3
  • MST103 3

External Ids for SLC30A6 Gene

Previous GeneCards Identifiers for SLC30A6 Gene

  • GC02P032518
  • GC02P032348
  • GC02P032365
  • GC02P032302
  • GC02P032244
  • GC02P032390
  • GC02P032130

Summaries for SLC30A6 Gene

Entrez Gene Summary for SLC30A6 Gene

  • Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A6 Gene

SLC30A6 (Solute Carrier Family 30 (Zinc Transporter), Member 6) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A7.

UniProtKB/Swiss-Prot for SLC30A6 Gene

  • Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A6 Gene

Genomics for SLC30A6 Gene

Regulatory Elements for SLC30A6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A6 Gene

Start:
32,165,841 bp from pter
End:
32,224,379 bp from pter
Size:
58,539 bases
Orientation:
Plus strand

Genomic View for SLC30A6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A6 Gene

Proteins for SLC30A6 Gene

  • Protein details for SLC30A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXT4-ZNT6_HUMAN
    Recommended name:
    Zinc transporter 6
    Protein Accession:
    Q6NXT4
    Secondary Accessions:
    • A5YM45
    • B7Z901
    • Q8N5C9
    • Q96NC3

    Protein attributes for SLC30A6 Gene

    Size:
    461 amino acids
    Molecular mass:
    51116 Da
    Quaternary structure:
    • Heterooligomer. Interacts with ZNT5 (By similarity).
    Miscellaneous:
    • Seems to have lost most of the histidine residues in the loop between the fourth and fifth transmembrane regions and appears to exert transport function by forming complexes with ZNT5.
    SequenceCaution:
    • Sequence=AAH32525.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC30A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A6 Gene

Proteomics data for SLC30A6 Gene at MOPED

Post-translational modifications for SLC30A6 Gene

  • Ubiquitination at Lys268
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC30A6 Gene

Domains for SLC30A6 Gene

Gene Families for SLC30A6 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A6 Gene

Graphical View of Domain Structure for InterPro Entry

Q6NXT4

UniProtKB/Swiss-Prot:

ZNT6_HUMAN :
  • Q6NXT4
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A6: view

Function for SLC30A6 Gene

Molecular function for SLC30A6 Gene

UniProtKB/Swiss-Prot Function: Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.

Gene Ontology (GO) - Molecular Function for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IEA --
GO:0008324 cation transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC30A6: view

Animal Model Products

CRISPR Products

miRNA for SLC30A6 Gene

miRTarBase miRNAs that target SLC30A6

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A6 Gene

Localization for SLC30A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A6 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A6 Gene COMPARTMENTS Subcellular localization image for SLC30A6 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 3
mitochondrion 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005739 mitochondrion IEA --
GO:0005794 Golgi apparatus IDA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A6: view

Pathways for SLC30A6 Gene

genes like me logo Genes that share pathways with SLC30A6: view

Interacting Proteins for SLC30A6 Gene

Gene Ontology (GO) - Biological Process for SLC30A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006829 zinc II ion transport --
GO:0006895 Golgi to endosome transport IEA --
GO:0044267 cellular protein metabolic process TAS --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC30A6: view

Transcripts for SLC30A6 Gene

Unigene Clusters for SLC30A6 Gene

Solute carrier family 30 (zinc transporter), member 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A6 Gene

No ASD Table

Relevant External Links for SLC30A6 Gene

GeneLoc Exon Structure for
SLC30A6
ECgene alternative splicing isoforms for
SLC30A6

Expression for SLC30A6 Gene

mRNA expression in normal human tissues for SLC30A6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A6 Gene

SOURCE GeneReport for Unigene cluster for SLC30A6 Gene Hs.23248

mRNA Expression by UniProt/SwissProt for SLC30A6 Gene

Q6NXT4-ZNT6_HUMAN
Tissue specificity: Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis.
genes like me logo Genes that share expressions with SLC30A6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC30A6 Gene

Orthologs for SLC30A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A6 35
  • 99.49 (n)
  • 99.35 (a)
SLC30A6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A6 35
  • 93.42 (n)
  • 96.1 (a)
SLC30A6 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A6 35
  • 93.13 (n)
  • 96.1 (a)
SLC30A6 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a6 35
  • 86.3 (n)
  • 92.39 (a)
Slc30a6 16
Slc30a6 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A6 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A6 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a6 35
  • 87.03 (n)
  • 91.96 (a)
chicken
(Gallus gallus)
Aves SLC30A6 35
  • 80.29 (n)
  • 90.65 (a)
SLC30A6 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A6 36
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4176 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a6 35
  • 76.47 (n)
  • 85.62 (a)
Str.5891 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28601 35
slc30a6 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea toc-1 36
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 36
  • 8 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5211 36
  • 34 (a)
OneToOne
Species with no ortholog for SLC30A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A6 Gene

ENSEMBL:
Gene Tree for SLC30A6 (if available)
TreeFam:
Gene Tree for SLC30A6 (if available)

Paralogs for SLC30A6 Gene

Paralogs for SLC30A6 Gene

Selected SIMAP similar genes for SLC30A6 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for SLC30A6 Gene

genes like me logo Genes that share paralogs with SLC30A6: view

Variants for SLC30A6 Gene

Sequence variations from dbSNP and Humsavar for SLC30A6 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs177081 -- 32,205,684(+) ttttt(A/T)gagac intron-variant
rs177082 -- 32,213,281(+) TGCCA(A/T)TGTTT intron-variant
rs177083 -- 32,222,649(+) CACTA(C/T)CTTGA utr-variant-3-prime
rs186135 -- 32,207,509(+) gtagc(C/T)gggac intron-variant
rs188465 -- 32,207,525(+) atgca(A/T)gccac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A6 Gene

Variant ID Type Subtype PubMed ID
nsv833670 CNV Loss 17160897
nsv873778 CNV Loss 21882294
esv2422335 CNV Duplication 17116639
nsv2667 CNV Loss 18451855
esv2719876 CNV Deletion 23290073
esv2719877 CNV Deletion 23290073

Relevant External Links for SLC30A6 Gene

HapMap Linkage Disequilibrium report
SLC30A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A6 Gene

Disorders for SLC30A6 Gene

Relevant External Links for SLC30A6

Genetic Association Database (GAD)
SLC30A6
Human Genome Epidemiology (HuGE) Navigator
SLC30A6
genes like me logo Genes that share disorders with SLC30A6: view

No data available for UniProtKB/Swiss-Prot for SLC30A6 Gene

Publications for SLC30A6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PMID: 15154973) Seve M. … Favier A. (BMC Genomics 2004) 3 4
  3. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. (PMID: 16580781) Smith J.L. … Lovell M.A. (Neuroscience 2006) 3 4
  4. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for SLC30A6 Gene

Sources for SLC30A6 Gene

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