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Aliases for SLC30A5 Gene

Aliases for SLC30A5 Gene

  • Solute Carrier Family 30 Member 5 2 3 4
  • Solute Carrier Family 30 (Zinc Transporter), Member 5 2 3 5
  • ZnT-Like Transporter 1 3 4
  • ZNTL1 3 4
  • ZnT-5 3 4
  • ZNT5 3 4
  • ZTL1 3 4
  • Zinc Transporter ZTL1 3
  • HZTL1 4

External Ids for SLC30A5 Gene

Previous GeneCards Identifiers for SLC30A5 Gene

  • GC05P068541
  • GC05P069955
  • GC05P068360
  • GC05P068405
  • GC05P068369
  • GC05P068425
  • GC05P068389
  • GC05P065345

Summaries for SLC30A5 Gene

Entrez Gene Summary for SLC30A5 Gene

  • This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

GeneCards Summary for SLC30A5 Gene

SLC30A5 (Solute Carrier Family 30 Member 5) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A6.

UniProtKB/Swiss-Prot for SLC30A5 Gene

  • Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A5 Gene

Genomics for SLC30A5 Gene

Regulatory Elements for SLC30A5 Gene

Promoters for SLC30A5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC30A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A5 Gene

Chromosome:
5
Start:
69,093,646 bp from pter
End:
69,131,072 bp from pter
Size:
37,427 bases
Orientation:
Plus strand

Genomic View for SLC30A5 Gene

Genes around SLC30A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A5 Gene

Proteins for SLC30A5 Gene

  • Protein details for SLC30A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAD4-ZNT5_HUMAN
    Recommended name:
    Zinc transporter 5
    Protein Accession:
    Q8TAD4
    Secondary Accessions:
    • B7ZM89
    • Q6UX54
    • Q7L4M4
    • Q8TDG3
    • Q9BVY8
    • Q9H9H1

    Protein attributes for SLC30A5 Gene

    Size:
    765 amino acids
    Molecular mass:
    84047 Da
    Quaternary structure:
    • Heterooligomer. Interacts with ZNT6.
    Miscellaneous:
    • The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP.
    SequenceCaution:
    • Sequence=BAB14258.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC30A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A5 Gene

Proteomics data for SLC30A5 Gene at MOPED

Post-translational modifications for SLC30A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC30A5 Gene

Domains & Families for SLC30A5 Gene

Gene Families for SLC30A5 Gene

Protein Domains for SLC30A5 Gene

Suggested Antigen Peptide Sequences for SLC30A5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TAD4

UniProtKB/Swiss-Prot:

ZNT5_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A5: view

Function for SLC30A5 Gene

Molecular function for SLC30A5 Gene

UniProtKB/Swiss-Prot Function:
Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
UniProtKB/Swiss-Prot Induction:
Down-regulated by ZNF658 in response to zinc.
genes like me logo Genes that share phenotypes with SLC30A5: view

Animal Models for SLC30A5 Gene

MGI Knock Outs for SLC30A5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A5

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A5 Gene

Localization for SLC30A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A5 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A5 Gene COMPARTMENTS Subcellular localization image for SLC30A5 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
plasma membrane 5
endosome 1

Gene Ontology (GO) - Cellular Components for SLC30A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with SLC30A5: view

Pathways & Interactions for SLC30A5 Gene

genes like me logo Genes that share pathways with SLC30A5: view

Interacting Proteins for SLC30A5 Gene

Gene Ontology (GO) - Biological Process for SLC30A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010043 response to zinc ion IDA 11937503
GO:0010155 regulation of proton transport NAS 11937503
GO:0044267 cellular protein metabolic process TAS --
GO:0055085 transmembrane transport IEA --
GO:0071577 zinc II ion transmembrane transport IDA,TAS --
genes like me logo Genes that share ontologies with SLC30A5: view

No data available for SIGNOR curated interactions for SLC30A5 Gene

Drugs & Compounds for SLC30A5 Gene

(1) Drugs for SLC30A5 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
genes like me logo Genes that share compounds with SLC30A5: view

Transcripts for SLC30A5 Gene

Unigene Clusters for SLC30A5 Gene

Solute carrier family 30 (zinc transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: -

Relevant External Links for SLC30A5 Gene

GeneLoc Exon Structure for
SLC30A5
ECgene alternative splicing isoforms for
SLC30A5

Expression for SLC30A5 Gene

mRNA expression in normal human tissues for SLC30A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC30A5 Gene

This gene is overexpressed in Nasal epithelium (56.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A5 Gene



SOURCE GeneReport for Unigene cluster for SLC30A5 Gene Hs.631975

mRNA Expression by UniProt/SwissProt for SLC30A5 Gene

Q8TAD4-ZNT5_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
genes like me logo Genes that share expression patterns with SLC30A5: view

Protein tissue co-expression partners for SLC30A5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC30A5 Gene

Orthologs for SLC30A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A5 35
  • 91.94 (n)
  • 94.51 (a)
SLC30A5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A5 35
  • 94.51 (n)
  • 96.73 (a)
SLC30A5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a5 35
  • 88.04 (n)
  • 93.82 (a)
Slc30a5 16
Slc30a5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A5 35
  • 98.62 (n)
  • 98.62 (a)
SLC30A5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a5 35
  • 87.63 (n)
  • 93.42 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A5 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A5 35
  • 78.96 (n)
  • 87.14 (a)
SLC30A5 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A5 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a5 35
  • 73.89 (n)
  • 80.29 (a)
Str.15099 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.33119 35
zebrafish
(Danio rerio)
Actinopterygii slc30a5 35
  • 70.08 (n)
  • 77.53 (a)
wufi03d07 35
slc30a5 36
  • 77 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13931 35
worm
(Caenorhabditis elegans)
Secernentea CELE_Y105E8A.3 35
  • 51.27 (n)
  • 44.41 (a)
Y105E8A.3 36
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 36
  • 22 (a)
OneToMany
Species with no ortholog for SLC30A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A5 Gene

ENSEMBL:
Gene Tree for SLC30A5 (if available)
TreeFam:
Gene Tree for SLC30A5 (if available)

Paralogs for SLC30A5 Gene

Paralogs for SLC30A5 Gene

(1) SIMAP similar genes for SLC30A5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC30A5 Gene

genes like me logo Genes that share paralogs with SLC30A5: view

Variants for SLC30A5 Gene

Sequence variations from dbSNP and Humsavar for SLC30A5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs149426 -- 69,111,599(+) acgcc(C/T)ggccT intron-variant
rs149578 -- 69,092,388(-) ctcca(C/T)aggca upstream-variant-2KB
rs186790 -- 69,128,630(-) TTAGC(A/T)ATTTT intron-variant
rs187043 -- 69,101,782(-) acagg(A/C/G)tttcg intron-variant
rs170893 -- 69,111,017(-) gactc(C/T)atctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A5 Gene

Variant ID Type Subtype PubMed ID
nsv881765 CNV Loss 21882294
nsv881766 CNV Loss 21882294

Variation tolerance for SLC30A5 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.60; 45.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A5 Gene

HapMap Linkage Disequilibrium report
SLC30A5
Human Gene Mutation Database (HGMD)
SLC30A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A5 Gene

Disorders for SLC30A5 Gene

Relevant External Links for SLC30A5

Genetic Association Database (GAD)
SLC30A5
Human Genome Epidemiology (HuGE) Navigator
SLC30A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A5

No disorders were found for SLC30A5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A5 Gene

Publications for SLC30A5 Gene

  1. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. (PMID: 11904301) Kambe T. … Nagao M. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. (PMID: 11937503) Cragg R.A. … Ford D. (J. Biol. Chem. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. (PMID: 23275032) Zhang X. … Ma J. (Cell. Signal. 2013) 3
  5. Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity. (PMID: 22529353) Hoch E. … Sekler I. (Proc. Natl. Acad. Sci. U.S.A. 2012) 3

Products for SLC30A5 Gene

Sources for SLC30A5 Gene

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