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Aliases for SLC30A5 Gene

Aliases for SLC30A5 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 5 2 3
  • ZNT5 3 4 6
  • ZTL1 3 4 6
  • ZnT-Like Transporter 1 3 4
  • ZNTL1 3 4
  • ZnT-5 3 4
  • Solute Carrier Family 30 Member 5 4
  • Zinc Transporter ZTL1 3
  • Zinc Transporter 5 3
  • HZTL1 4

External Ids for SLC30A5 Gene

Summaries for SLC30A5 Gene

Entrez Gene Summary for SLC30A5 Gene

  • This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

GeneCards Summary for SLC30A5 Gene

SLC30A5 (Solute Carrier Family 30 (Zinc Transporter), Member 5) is a Protein Coding gene. Diseases associated with SLC30A5 include acrodermatitis and enteropathica. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A6.

UniProtKB/Swiss-Prot for SLC30A5 Gene

  • Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A5 Gene

Genomics for SLC30A5 Gene

Genomic Location for SLC30A5 Gene

Start:
69,093,646 bp from pter
End:
69,131,072 bp from pter
Size:
37,427 bases
Orientation:
Plus strand

Genomic View for SLC30A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A5 Gene

Regulatory Elements for SLC30A5 Gene

Proteins for SLC30A5 Gene

  • Protein details for SLC30A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAD4-ZNT5_HUMAN
    Recommended name:
    Zinc transporter 5
    Protein Accession:
    Q8TAD4
    Secondary Accessions:
    • B7ZM89
    • Q6UX54
    • Q7L4M4
    • Q8TDG3
    • Q9BVY8
    • Q9H9H1

    Protein attributes for SLC30A5 Gene

    Size:
    765 amino acids
    Molecular mass:
    84047 Da
    Quaternary structure:
    • Heterooligomer. Interacts with ZNT6.
    Miscellaneous:
    • The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP
    SequenceCaution:
    • Sequence=BAB14258.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC30A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A5 Gene

Proteomics data for SLC30A5 Gene at MOPED

Post-translational modifications for SLC30A5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A5 Gene

No data available for DME Specific Peptides for SLC30A5 Gene

Domains for SLC30A5 Gene

Gene Families for SLC30A5 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A5 Gene

UniProtKB/Swiss-Prot:

ZNT5_HUMAN
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.:
    • Q8TAD4
genes like me logo Genes that share domains with SLC30A5: view

Function for SLC30A5 Gene

Molecular function for SLC30A5 Gene

UniProtKB/Swiss-Prot Function: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP.
UniProtKB/Swiss-Prot Induction: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce any up- or down-regulation of gene expression. Up-regulated by zinc depletion.

Gene Ontology (GO) - Molecular Function for SLC30A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IDA 10330022
GO:0008270 zinc ion binding NAS 11937503
GO:0008324 cation transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC30A5: view
genes like me logo Genes that share phenotypes with SLC30A5: view

Animal Models for SLC30A5 Gene

MGI Knock Outs for SLC30A5:

miRNA for SLC30A5 Gene

miRTarBase miRNAs that target SLC30A5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC30A5 Gene

Localization for SLC30A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A5 Gene

Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the secretory pathway such as COPII-coated vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A5 Gene COMPARTMENTS Subcellular localization image for SLC30A5 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 4
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC30A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane --
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005887 integral component of plasma membrane TAS 11937503
genes like me logo Genes that share ontologies with SLC30A5: view

Pathways for SLC30A5 Gene

genes like me logo Genes that share pathways with SLC30A5: view

Interacting Proteins for SLC30A5 Gene

Gene Ontology (GO) - Biological Process for SLC30A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006824 cobalt ion transport IDA 10330022
GO:0006829 zinc II ion transport IDA 10330022
GO:0006882 cellular zinc ion homeostasis IDA 11937503
GO:0010043 response to zinc ion IDA 11937503
genes like me logo Genes that share ontologies with SLC30A5: view

Compounds for SLC30A5 Gene

(1) HMDB Compounds for SLC30A5 Gene

Compound Synonyms Cas Number PubMed IDs
Zinc
  • Zinc
7440-66-6

(1) Novoseek inferred chemical compound relationships for SLC30A5 Gene

Compound -log(P) Hits PubMed IDs
zinc 59.8 8
genes like me logo Genes that share compounds with SLC30A5: view

Transcripts for SLC30A5 Gene

Unigene Clusters for SLC30A5 Gene

Solute carrier family 30 (zinc transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - - -
SP9: - -
SP10:
SP11:
SP12:

ExUns: 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2:
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9:
SP10: - -
SP11:
SP12: -

Relevant External Links for SLC30A5 Gene

GeneLoc Exon Structure for
SLC30A5
ECgene alternative splicing isoforms for
SLC30A5

Expression for SLC30A5 Gene

mRNA expression in normal human tissues for SLC30A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for SLC30A5 Gene

SOURCE GeneReport for Unigene cluster for SLC30A5 Gene Hs.631975

mRNA Expression by UniProt/SwissProt for SLC30A5 Gene

Q8TAD4-ZNT5_HUMAN
Tissue specificity: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha cells and most acinar cells.
genes like me logo Genes that share expressions with SLC30A5: view

Orthologs for SLC30A5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A5 36
  • 98.62 (n)
  • 98.62 (a)
SLC30A5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A5 36
  • 91.94 (n)
  • 94.51 (a)
SLC30A5 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A5 36
  • 94.51 (n)
  • 96.73 (a)
SLC30A5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a5 36
  • 88.04 (n)
  • 93.82 (a)
Slc30a5 16
Slc30a5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A5 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a5 36
  • 87.63 (n)
  • 93.42 (a)
chicken
(Gallus gallus)
Aves SLC30A5 36
  • 78.96 (n)
  • 87.14 (a)
SLC30A5 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A5 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33119 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a5 36
  • 73.89 (n)
  • 80.29 (a)
Str.15099 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13931 36
zebrafish
(Danio rerio)
Actinopterygii slc30a5 36
  • 70.08 (n)
  • 77.53 (a)
slc30a5 37
  • 77 (a)
OneToOne
wufi03d07 36
worm
(Caenorhabditis elegans)
Secernentea CELE_Y105E8A.3 36
  • 51.27 (n)
  • 44.41 (a)
Y105E8A.3 37
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MSC2 37
  • 22 (a)
OneToMany
Species with no ortholog for SLC30A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A5 Gene

ENSEMBL:
Gene Tree for SLC30A5 (if available)
TreeFam:
Gene Tree for SLC30A5 (if available)

Paralogs for SLC30A5 Gene

Paralogs for SLC30A5 Gene

Selected SIMAP similar genes for SLC30A5 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for SLC30A5 Gene

genes like me logo Genes that share paralogs with SLC30A5: view

Variants for SLC30A5 Gene

Sequence variations from dbSNP and Humsavar for SLC30A5 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs149426 -- 69,111,599(+) acgcc(C/T)ggccT intron-variant
rs149578 -- 69,092,388(-) ctcca(C/T)aggca upstream-variant-2KB
rs163193 -- 69,093,012(-) CTCTA(C/T)CAAAA upstream-variant-2KB
rs164392 -- 69,113,787(+) GCAGA(A/G)CTCCA intron-variant
rs164393 -- 69,113,267(-) TTTCC(A/G/T)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A5 Gene

Variant ID Type Subtype PubMed ID
nsv881765 CNV Loss 21882294
nsv881766 CNV Loss 21882294

Relevant External Links for SLC30A5 Gene

HapMap Linkage Disequilibrium report
SLC30A5
Human Gene Mutation Database (HGMD)
SLC30A5

Disorders for SLC30A5 Gene

(1) University of Copenhagen DISEASES for SLC30A5 Gene

Relevant External Links for SLC30A5

Genetic Association Database (GAD)
SLC30A5
Human Genome Epidemiology (HuGE) Navigator
SLC30A5
genes like me logo Genes that share disorders with SLC30A5: view

No data available for UniProtKB/Swiss-Prot for SLC30A5 Gene

Publications for SLC30A5 Gene

  1. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. (PMID: 11904301) Kambe T. … Nagao M. (J. Biol. Chem. 2002) 2 3 4 23
  2. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. (PMID: 11937503) Cragg R.A. … Ford D. (J. Biol. Chem. 2002) 2 3 4
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for SLC30A5 Gene

Sources for SLC30A5 Gene

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