Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC30A5 Gene

protein-coding   GIFtS: 56
GCID: GC05P068389

Solute Carrier Family 30 (Zinc Transporter), Member 5

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 51 2     ZnT-52 3
ZNT52 3 5     Zinc Transporter 52
ZTL12 3 5     Zinc Transporter ZTL12
ZnT-Like Transporter 12 3     hZTL13
ZNTL12 3     Solute Carrier Family 30 Member 53

External Ids:    HGNC: 190891   Entrez Gene: 649242   Ensembl: ENSG000001457407   OMIM: 6078195   UniProtKB: Q8TAD43   

Export aliases for SLC30A5 gene to outside databases

Previous GC identifers: GC05P068541 GC05P069955 GC05P068360 GC05P068405 GC05P068369 GC05P068425 GC05P065345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC30A5 Gene:
This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both
cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in
the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration
into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple
isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome
19. (provided by RefSeq, Oct 2011)

GeneCards Summary for SLC30A5 Gene: 
SLC30A5 (solute carrier family 30 (zinc transporter), member 5) is a protein-coding gene. Diseases associated with SLC30A5 include acrodermatitis, and enteropathica, and among its related super-pathways are Transmembrane transport of small molecules and Zinc transporters. GO annotations related to this gene include zinc ion transmembrane transporter activity and zinc ion binding. An important paralog of this gene is SLC30A7.

UniProtKB/Swiss-Prot: ZNT5_HUMAN, Q8TAD4
Function: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin
crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring
enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular
compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the
activation of TNAP




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC30A5 gene promoter:
         HTF   FOXJ2 (long isoform)   FOXJ2   Tal-1beta   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC30A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q12.1   Ensembl cytogenetic band:  5q13.1   HGNC cytogenetic band: 5q13.1

SLC30A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A5 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068389:  view genomic region     (about GC identifiers)

Start:
68,389,473 bp from pter      End:
68,426,899 bp from pter
Size:
37,427 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNT5_HUMAN, Q8TAD4 (See protein sequence)
Recommended Name: Zinc transporter 5  
Size: 765 amino acids; 84047 Da
Subunit: Heterooligomer. Interacts with ZNT6
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Perimeter
of granules, localizes to the brush border membrane of the enterocyte. Concentrated in early compartments of the
secretory pathway such as COPII-coated vesicles
Miscellaneous: The histidine-rich loop is essential for ZNT5 and ZNT6 heterooligomeric complexes to activate TNAP
Sequence caution: Sequence=BAB14258.1; Type=Erroneous initiation;
Secondary accessions: B7ZM89 Q6UX54 Q7L4M4 Q8TDG3 Q9BVY8 Q9H9H1
Alternative splicing: 4 isoforms:  Q8TAD4-1   Q8TAD4-2   Q8TAD4-3   Q8TAD4-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC30A5: NX_Q8TAD4

Explore proteomics data for SLC30A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8TAD4

  • SLC30A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC30A5 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001238898.1  NP_075053.2  NP_076960.1  

    ENSEMBL proteins: 
     ENSP00000379836   ENSP00000370241   ENSP00000426751   ENSP00000421251   ENSP00000427111  
     ENSP00000423078  
    Reactome Protein details: Q8TAD4
    Human Recombinant Protein Products for SLC30A5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC30A5
    GenScript Custom Purified and Recombinant Proteins Services for SLC30A5
    Novus Biologicals SLC30A5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC30A5 

    Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005887integral to plasma membrane TAS11937503

    SLC30A5 for ontologies           About GeneDecksing



    SLC30A5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC30A5
    GenScript Custom Superior Antibodies Services for SLC30A5
    Novus Biologicals SLC30A5 Antibodies
    Abcam antibodies for SLC30A5
    Cloud-Clone Corp. Antibodies for SLC30A5 
    Search ThermoFisher Antibodies for SLC30A5
    Search LSBio for Antibodies for SLC30A5 

    Assay Products for SLC30A5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC30A5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC30A5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC30A5 
    Cloud-Clone Corp. CLIAs for SLC30A5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 5 
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q8TAD4

    ProtoNet protein and cluster: Q8TAD4

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT5_HUMAN, Q8TAD4
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    SLC30A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT5_HUMAN, Q8TAD4
    Function: Functions as a zinc transporter. May be a transporter of zinc into beta cells in order to form insulin
    crystals. Partly regulates cellular zinc homeostasis. Required with ZNT7 for the activation of zinc-requiring
    enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and vesicular
    compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the
    activation of TNAP
    Induction: Increased intracellular zinc level, resulting from extracellular zinc supplementation, do not induce
    any up- or down-regulation of gene expression. Up-regulated by zinc depletion

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IDA10330022
    GO:0008270zinc ion binding NAS11937503
    GO:0008324cation transmembrane transporter activity ----
         
    SLC30A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC30A5:
     Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc30a5):
     adipose tissue  behavior/neurological  cardiovascular system  growth/size  limbs/digits/tail 
     mortality/aging  skeleton 

    SLC30A5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc30a5tm1Ynak for SLC30A5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC30A5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC30A5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC30A5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC30A5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A5
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A5 (see all 40):
    hsa-miR-194* hsa-miR-548j hsa-miR-140-5p hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-4328 hsa-miR-429
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC30A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC30A5
    Sirion Biotech Customized adenovirus for overexpression of SLC30A5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC30A5 (see all 9)
    OriGene ORF clones in mouse, rat for SLC30A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A5 (NM_022902)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A5
    Sirion Biotech Customized lentivirus for stable overexpression of SLC30A5 
                         Customized lentivirus expression plasmids for stable overexpression of SLC30A5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC30A5
    Search LifeMap BioReagents cell lines for SLC30A5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC30A5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Zinc transporters
    Zinc transporters0.68
    Zinc efflux and compartmentalization by the SLC30 family0.41
    Metal ion SLC transporters0.68
    3Insulin Processing
    Peptide hormone metabolism0.39
    Insulin Processing0.39
    4Asparagine N-linked glycosylation
    Metabolism of proteins0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/9        Reactome Pathways for SLC30A5 (see all 9)
        Zinc efflux and compartmentalization by the SLC30 family
    Insulin Processing
    Metal ion SLC transporters
    Zinc transporters
    SLC-mediated transmembrane transport



    SLC30A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC30A5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC30A5 (ENSP000003798364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    PIGNENSP000003502634STRING: ENSP00000350263
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006824cobalt ion transport IDA10330022
    GO:0006829zinc ion transport IDA10330022
    GO:0006882cellular zinc ion homeostasis IDA11937503
    GO:0010043response to zinc ion IDA11937503

    SLC30A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC30A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC30A5 (ZNT5)

    1 HMDB Compound for SLC30A5    About this table
    CompoundSynonyms CAS #PubMed Ids
    ZincZinc (see all 2)7440-66-6--

    1 Novoseek inferred chemical compound relationship for SLC30A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 59.8 17 17234632 (4), 11904301 (2), 15538632 (1), 19245740 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC30A5 / ZNT5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC30A5 gene (3 alternative transcripts): 
    NM_001251969.1  NM_022902.4  NM_024055.4  

    Unigene Cluster for SLC30A5:

    Solute carrier family 30 (zinc transporter), member 5
    Hs.631975  [show with all ESTs]
    Unigene Representative Sequence: NM_022902
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396591(uc003jvh.3 uc003jvj.3 uc003jvk.3) ENST00000380860(uc003jvg.3 uc011crc.2)
    ENST00000504103 ENST00000502979 ENST00000507354(uc003jvi.3) ENST00000513937
    ENST00000512367 ENST00000511158

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A5
    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A5 (see all 40):
    hsa-miR-194* hsa-miR-548j hsa-miR-140-5p hsa-miR-579 hsa-miR-26a-2* hsa-miR-640 hsa-miR-4328 hsa-miR-429
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC30A5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A5
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC30A5 (see all 9)
    OriGene ORF clones in mouse, rat for SLC30A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A5 (NM_022902)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A5
    Sirion Biotech Customized lentivirus for stable overexpression of SLC30A5 
                         Customized lentivirus expression plasmids for stable overexpression of SLC30A5 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC30A5
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC30A5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A5

    Additional mRNA sequence: 

    AF212235.1 AF461760.1 AK022558.1 AK022818.1 AK292925.1 AL833716.1 AY089991.1 AY358505.1 
    BC000808.1 BC003411.1 BC008198.1 BC017441.1 BC130452.1 BC130454.1 BC144349.1 BX537394.1 
    JF802034.1 

    8 DOTS entries:

    DT.441572  DT.100789490  DT.100789482  DT.100789487  DT.100789486  DT.91760957  DT.91999517  DT.95229902 

    24/172 AceView cDNA sequences (see all 172):

    BC017441 CK903528 BX284072 N68128 NM_024055 BM564843 AA412665 BM852691 
    BX282349 AA598723 BQ438983 BF793567 NM_022902 BU621000 CR595184 BC000808 
    AI913535 CA422485 BX956264 AI740876 AW204604 AU124097 BC008198 BP352932 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A5 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a ·
    SP1:                                -           -     -                                                                             -                       -   
    SP2:                                            -     -     -                                                                       -                       -   
    SP3:                                                                                                                                -           -           -   
    SP4:                          -     -           -     -                                                                                                         
    SP5:                                                                                                                                -                       -   

    ExUns: 15b · 15c ^ 16 ^ 17 ^ 18a · 18b · 18c · 18d
    SP1:        -     -                                 
    SP2:                                                
    SP3:        -     -                                 
    SP4:                                                
    SP5:        -     -     -                           


    ECgene alternative splicing isoforms for SLC30A5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC30A5 expression in normal human tissues (normalized intensities)      SLC30A5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTTGCTGG
    SLC30A5 Expression
    About this image


    SLC30A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Blood (Extraembryonic Tissues)
             cord blood   
     
     Spinal Cord (Nervous System)
             Dorsal Root Ganglion   
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See SLC30A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC30A5

    SOURCE GeneReport for Unigene cluster: Hs.631975

    UniProtKB/Swiss-Prot: ZNT5_HUMAN, Q8TAD4
    Tissue specificity: Ubiquitously expressed. Highly expressed in pancreas, liver and kidney. Expressed abundantly
    in insulin-containing beta cells, undetectable in other endocrine cell types including glucagon-secreting alpha
    cells and most acinar cells

        SABiosciences Custom PCR Arrays for SLC30A5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC30A5
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC30A5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC30A5 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a51 , 5 solute carrier family 30 (zinc transporter), member more1, 5 89.44(n)1
    95.4(a)1
      13 (53.23 cM)5
    690481  NM_022885.21  NP_075023.21 
     1008026495 
    chicken
    (Gallus gallus)
    Aves SLC30A51 solute carrier family 30 (zinc transporter), member more 80.88(n)
    89.34(a)
      427173  NM_001031419.2  NP_001026590.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A56
    Uncharacterized protein
    85(a)
    1 ↔ 1
    2(12334265-12363016)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.331192 Xenopus laevis transcribed sequence with moderate similarity more 74.93(n)    48061894 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi03d072 Transcribed sequence with weak similarity to protein more 73.94(n)    57062509 
    worm
    (Caenorhabditis elegans)
    Secernentea CELE_Y105E8A.31 Protein Y105E8A.3 51.41(n)
    44.3(a)
      173299  NM_170935.6  NP_740931.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MSC26
    Member of the cation diffusion facilitator family,...
    22(a)
    1 → many
    IV(859346-861520)


    ENSEMBL Gene Tree for SLC30A5 (if available)
    TreeFam Gene Tree for SLC30A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC30A5 gene
    SLC30A72  SLC30A62  
    1 SIMAP similar gene for SLC30A5 using alignment to 4 protein entries:     ZNT5_HUMAN (see all proteins):
    SLC30A7

    SLC30A5 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC30A5
    PGOHUM00000234358


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/835 SNPs in SLC30A5 are shown (see all 835)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006034661,2
    C--68307225(+) ATAGG-/GGCTGGGT 3 -- us2k10--------
    rs2005171541,2
    --68307299(+) TTATT-/ATTTTT 3 -- us2k10--------
    rs1128931631,2
    C,F--68307353(+) CAATGG/TCGCGA 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1819927381,2
    --68307354(+) AATGGC/TGCGAT 3 -- us2k10--------
    rs1858310151,2
    --68307385(+) ATCTCA/CGGGTT 3 -- us2k10--------
    rs1118640661,2
    C,F--68307435(+) TACAGG/TCATGC 3 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs77128521,2
    C--68307488(+) gtttcA/Gccatg 3 -- us2k10--------
    rs1419569261,2
    --68307537(+) CCACCC/TGCCTC 3 -- us2k10--------
    rs1450965781,2
    --68307538(+) CACCCA/GCCTCA 3 -- us2k10--------
    rs1920813231,2
    --68307578(+) AGCCAC/TTGTGC 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC30A5 (68389473 - 68426899 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC30A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv881765CNV Loss21882294
    nsv881766CNV Loss21882294


    Human Gene Mutation Database (HGMD): SLC30A5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607819    OMIM disorders: --

    8 diseases for SLC30A5:    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    nonsyndromic deafness
    pancreatitis    alzheimer's disease    lung cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLC30A5:
    Acrodermatitis enteropathica

    SLC30A5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): SLC30A5
    Human Genome Epidemiology (HuGE) Navigator: SLC30A5 (2 documents)

    Export disorders for SLC30A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC30A5 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with SLC30A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a novel mammalian zinc transporter, zinc transporter 5, abundantly expressed in pancreatic beta cells. (PubMed id 11904301)1, 2, 3, 9 Kambe T....Nagao M. (2002)
    2. A novel zinc-regulated human zinc transporter, hZTL1, is localized to the enterocyte apical membrane. (PubMed id 11937503)1, 2, 3 Cragg R.A.... Ford D. (2002)
    3. Genetic variation and antioxidant response gene expre ssion in the bronchial airway epithelium of smokers at risk for lung cancer. (PubMed id 20689807)1, 4 Wang X....Bell D.A. (2010)
    4. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    5. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. (PubMed id 15276077)1, 2 Devergnas S.... Seve M. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    8. Zinc transporter 5 and zinc transporter 7 induced by h igh glucose protects peritoneal mesothelial cells from undergoing apoptosis. (PubMed id 23275032)1 Zhang X....Ma J. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64924 HGNC: 19089 AceView: SLC30A5 Ensembl:ENSG00000145740 euGenes: HUgn64924
    ECgene: SLC30A5 H-InvDB: SLC30A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC30A5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC30A5 gene:
    Search GeneIP for patents involving SLC30A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC30A5  
     OriGene qPCR primer pairs and template standards for SLC30A5   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC30A5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC30A5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC30A5   OriGene Custom Protein Services for SLC30A5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC30A5
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC30A5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A5
     GenScript Custom Purified and Recombinant Proteins Services for SLC30A5 GenScript cDNA clones with any tag delivered in your preferred vector for SLC30A5
     GenScript Custom Assay Services for SLC30A5 GenScript Custom Superior Antibodies Services for SLC30A5
     GenScript Custom overexpressing Cell Line Services for SLC30A5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC30A5 promoter
     Search Chromatin IP Primers for SLC30A5
     RT2 qPCR Primer Assay in human, mouse, rat SLC30A5
     Search GNC Networks for SLC30A5
     SABiosciences Custom PCR Arrays for SLC30A5
     Search Tocris compounds for SLC30A5 (ZNT5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC30A5 antibodies
     SLC30A5 proteins
     Antibodies for SLC30A5
     See all of Abcam's Antibodies, Kits and Proteins for SLC30A5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC30A5
     Antibodies for SLC30A5
     ELISAs for SLC30A5
     CLIAs for SLC30A5
     Search LifeMap BioReagents cell lines for SLC30A5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A5
     SwitchGear 3'UTR luciferase reporter plasmids for SLC30A5
     SwitchGear Promoter luciferase reporter plasmids for SLC30A5
     Search ThermoFisher Antibodies for SLC30A5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC30A5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC30A5
    Customized:
     lentivirus for stable overexpression of SLC30A5
     lentivirus expression plasmids for stable overexpression of SLC30A5
     adenovirus for overexpression of SLC30A5
     Search LSBio for Antibodies for SLC30A5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC30A5 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4