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Aliases for SLC30A4 Gene

Aliases for SLC30A4 Gene

  • Solute Carrier Family 30 Member 4 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 4 2 3
  • ZnT-4 3 4
  • ZNT4 3 4
  • Zinc Transporter 4 3

External Ids for SLC30A4 Gene

Previous HGNC Symbols for SLC30A4 Gene

  • ZNT4

Previous GeneCards Identifiers for SLC30A4 Gene

  • GC15M041333
  • GC15M038822
  • GC15M043356
  • GC15M043493
  • GC15M043486
  • GC15M043564
  • GC15M045771
  • GC15M022597

Summaries for SLC30A4 Gene

Entrez Gene Summary for SLC30A4 Gene

  • Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A4 Gene

SLC30A4 (Solute Carrier Family 30 Member 4) is a Protein Coding gene. Diseases associated with SLC30A4 include Acrodermatitis Enteropathica and Enteropathica. GO annotations related to this gene include cation transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A2.

UniProtKB/Swiss-Prot for SLC30A4 Gene

  • Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

Gene Wiki entry for SLC30A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A4 Gene

Genomics for SLC30A4 Gene

Regulatory Elements for SLC30A4 Gene

Enhancers for SLC30A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around SLC30A4 on UCSC Golden Path with GeneCards custom track

Promoters for SLC30A4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC30A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A4 Gene

Chromosome:
15
Start:
45,479,611 bp from pter
End:
45,523,669 bp from pter
Size:
44,059 bases
Orientation:
Minus strand

Genomic View for SLC30A4 Gene

Genes around SLC30A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A4 Gene

Proteins for SLC30A4 Gene

  • Protein details for SLC30A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14863-ZNT4_HUMAN
    Recommended name:
    Zinc transporter 4
    Protein Accession:
    O14863
    Secondary Accessions:
    • Q8TC39

    Protein attributes for SLC30A4 Gene

    Size:
    429 amino acids
    Molecular mass:
    47483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC30A4 Gene

Post-translational modifications for SLC30A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC30A4 Gene

Domains & Families for SLC30A4 Gene

Gene Families for SLC30A4 Gene

Protein Domains for SLC30A4 Gene

Suggested Antigen Peptide Sequences for SLC30A4 Gene

Graphical View of Domain Structure for InterPro Entry

O14863

UniProtKB/Swiss-Prot:

ZNT4_HUMAN :
  • Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Domain:
  • Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A4: view

Function for SLC30A4 Gene

Molecular function for SLC30A4 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

Gene Ontology (GO) - Molecular Function for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS 9354792
genes like me logo Genes that share ontologies with SLC30A4: view
genes like me logo Genes that share phenotypes with SLC30A4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A4 Gene

Localization for SLC30A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A4 Gene

Endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A4 Gene COMPARTMENTS Subcellular localization image for SLC30A4 gene
Compartment Confidence
endosome 5
lysosome 4
plasma membrane 4
vacuole 4
golgi apparatus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005765 lysosomal membrane IEA --
GO:0005770 late endosome IDA 17349999
GO:0016020 membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A4: view

Pathways & Interactions for SLC30A4 Gene

SuperPathways for SLC30A4 Gene

No Data Available

Interacting Proteins for SLC30A4 Gene

Gene Ontology (GO) - Biological Process for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009636 response to toxic substance IDA 17575980
GO:0010043 response to zinc ion IBA --
GO:0055069 zinc ion homeostasis IEA --
GO:0061088 regulation of sequestering of zinc ion IDA 17349999
GO:0071577 zinc II ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC30A4: view

No data available for Pathways by source and SIGNOR curated interactions for SLC30A4 Gene

Drugs & Compounds for SLC30A4 Gene

(1) Drugs for SLC30A4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC30A4: view

Transcripts for SLC30A4 Gene

Unigene Clusters for SLC30A4 Gene

Solute carrier family 30 (zinc transporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A4 Gene

No ASD Table

Relevant External Links for SLC30A4 Gene

GeneLoc Exon Structure for
SLC30A4
ECgene alternative splicing isoforms for
SLC30A4

Expression for SLC30A4 Gene

mRNA expression in normal human tissues for SLC30A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A4 Gene

This gene is overexpressed in Prostate (x4.2).

Protein differential expression in normal tissues from HIPED for SLC30A4 Gene

This gene is overexpressed in Testis (33.5), Placenta (21.0), and Bone (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC30A4 Gene



Protein tissue co-expression partners for SLC30A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC30A4 Gene:

SLC30A4

SOURCE GeneReport for Unigene cluster for SLC30A4 Gene:

Hs.162989
genes like me logo Genes that share expression patterns with SLC30A4: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A4 Gene

Orthologs for SLC30A4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A4 34
  • 93.07 (n)
  • 94.39 (a)
SLC30A4 35
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A4 34
  • 94.24 (n)
  • 95.09 (a)
SLC30A4 35
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a4 34
  • 88.76 (n)
  • 92.27 (a)
Slc30a4 16
Slc30a4 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A4 34
  • 99.69 (n)
  • 99.3 (a)
SLC30A4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a4 34
  • 86.89 (n)
  • 90.85 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC30A4 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A4 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A4 34
  • 73.59 (n)
  • 77.09 (a)
SLC30A4 35
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A4 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a4 34
  • 68.48 (n)
  • 68.15 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a4 34
  • 57.21 (n)
  • 61.94 (a)
zgc64215 34
slc30a4 35
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG11163 35
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T18D3.3 36
  • 39 (a)
Y39E4A.2a 36
  • 40 (a)
Y39E4A.2b 36
  • 40 (a)
ttm-1 35
  • 32 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 35
  • 20 (a)
ManyToMany
ZRC1 35
  • 19 (a)
ManyToMany
MMT1 37
thale cress
(Arabidopsis thaliana)
eudicotyledons MTPB1 34
  • 46.79 (n)
  • 34.62 (a)
Species where no ortholog for SLC30A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A4 Gene

ENSEMBL:
Gene Tree for SLC30A4 (if available)
TreeFam:
Gene Tree for SLC30A4 (if available)

Paralogs for SLC30A4 Gene

Paralogs for SLC30A4 Gene

(4) SIMAP similar genes for SLC30A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC30A4: view

Variants for SLC30A4 Gene

Sequence variations from dbSNP and Humsavar for SLC30A4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2643718 -- 45,502,464(+) cactg(C/T)agcct intron-variant
rs3067045 -- 45,500,609(-) cagaC(-/AGAC)CCTTA intron-variant
rs3104172 -- 45,489,741(+) ttgtg(C/G)acatg intron-variant
rs3110168 -- 45,500,618(+) TGTCT(A/G)TCTAT intron-variant
rs3110169 -- 45,489,740(+) gttgt(C/G)cacat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A4 Gene

Variant ID Type Subtype PubMed ID
esv3569553 CNV gain 25503493
esv3892684 CNV gain 25118596
nsv1045556 CNV gain 25217958
nsv1160292 CNV duplication 26073780
nsv1523 CNV deletion 18451855
nsv469721 CNV gain 16826518
nsv519435 CNV loss 19592680

Variation tolerance for SLC30A4 Gene

Residual Variation Intolerance Score: 23.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC30A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A4 Gene

Disorders for SLC30A4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC30A4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acrodermatitis enteropathica
  • acrodermatitis enteropathica, zinc-deficiency type
enteropathica
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC30A4

Genetic Association Database (GAD)
SLC30A4
Human Genome Epidemiology (HuGE) Navigator
SLC30A4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A4
genes like me logo Genes that share disorders with SLC30A4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC30A4 Gene

Publications for SLC30A4 Gene

  1. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PMID: 17349999) FalcA^n-PAcrez J.M. … Dell'Angelica E.C. (Exp. Cell Res. 2007) 3 4 22 65
  2. Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. (PMID: 19371353) Lyubartseva G. … Lovell M.A. (Brain Pathol. 2010) 3 22 65
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 65
  4. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PMID: 19058789) de Krom M. … van Ree J.M. (Biol. Psychiatry 2009) 3 46 65
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 65

Products for SLC30A4 Gene

Sources for SLC30A4 Gene

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