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SLC30A4 Gene

protein-coding   GIFtS: 56
GCID: GC15M045771

Solute Carrier Family 30 (Zinc Transporter), Member 4


(Previous symbol: ZNT4)
  See SLC30A4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 41 2
ZNT41 2 3 5
Solute Carrier Family 30 Member 42 3
Zinc Transporter 42
znT-42
ZnT-43

External Ids:    HGNC: 110151   Entrez Gene: 77822   Ensembl: ENSG000001041547   OMIM: 6020955   UniProtKB: O148633   

Export aliases for SLC30A4 gene to outside databases

Previous GC identifers: GC15M041333 GC15M038822 GC15M043356 GC15M043493 GC15M043486 GC15M043564 GC15M022597


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC30A4 Gene:
Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a
structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in
metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM
171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the
ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar
structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier,
1997 (PubMed 9354792)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC30A4 Gene:
SLC30A4 (solute carrier family 30 (zinc transporter), member 4) is a protein-coding gene. Diseases associated with SLC30A4 include acrodermatitis enteropathica, and enteropathica. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A3.

UniProtKB/Swiss-Prot: ZNT4_HUMAN, O14863
Function: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular
compartment

Gene Wiki entry for SLC30A4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A4 gene promoter:
         Pax-5   AML1a   Pax-2   Pax-2a   STAT5A   N-Myc   FOXO4   STAT3   c-Myb   TGIF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A4 promoter sequence
   Search Chromatin IP Primers for SLC30A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1|15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q21.1

SLC30A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M045771:  view genomic region     (about GC identifiers)

Start:
45,771,809 bp from pter      End:
45,815,005 bp from pter
Size:
43,197 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNT4_HUMAN, O14863 (See protein sequence)
Recommended Name: Zinc transporter 4  
Size: 429 amino acids; 47483 Da
Secondary accessions: Q8TC39

Explore the universe of human proteins at neXtProt for SLC30A4: NX_O14863

Explore proteomics data for SLC30A4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC30A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_037441.2  
    ENSEMBL proteins: 
     ENSP00000261867  

    SLC30A4 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for SLC30A4

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 4
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry O14863

    ProtoNet protein and cluster: O14863

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT4_HUMAN, O14863
    Domain: Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a
    potential ligand for zinc (By similarity)
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    Find genes that share domains with SLC30A4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT4_HUMAN, O14863
    Function: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular
    compartment

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity TAS9354792
    GO:0008324cation transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC30A4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC30A4:
     Upregulation of Wnt/beta-caten 

         11 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc30a4):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  hearing/vestibular/ear  homeostasis/metabolism 
     immune system  integument  mortality/aging  other  pigmentation 
     vision/eye 

    Find genes that share phenotypes with SLC30A4           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC30A4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC30A4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC30A4

    miRNA
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    miRTarBase miRNAs that target SLC30A4:
    hsa-mir-9-5p (MIRT021423)

    Block miRNA regulation of human, mouse, rat SLC30A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC30A4 (see all 101):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-134 hsa-miR-219-5p hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A4 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC30A4 (NM_013309)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNT4_HUMAN, O14863: Endosome membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane3
    golgi apparatus2
    lysosome1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17349999
    GO:0005770late endosome IDA17349999
    GO:0010008endosome membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC30A4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including SLC30A4: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for SLC30A4

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for SLC30A4 (ENSP000002618674) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PISDENSP000002660954STRING: ENSP00000266095
    SLC39A10ENSP000003526554STRING: ENSP00000352655
    SLC39A5ENSP000002669804STRING: ENSP00000266980
    SLC39A6ENSP000002691874STRING: ENSP00000269187
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0009636response to toxic substance IDA17575980
    GO:0055069zinc ion homeostasis IEA--
    GO:0055085transmembrane transport ----
    GO:0061088regulation of sequestering of zinc ion IDA17349999

    Find genes that share ontologies with SLC30A4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC30A4 (ZNT4)

    1 Novoseek inferred chemical compound relationship for SLC30A4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 61.8 19 19371353 (2), 11686514 (2), 18850219 (1), 12743795 (1) (see all 8)



    Find genes that share compounds with SLC30A4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC30A4 gene: 
    NM_013309.4  

    Unigene Cluster for SLC30A4:

    Solute carrier family 30 (zinc transporter), member 4
    Hs.162989  [show with all ESTs]
    Unigene Representative Sequence: NM_013309
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261867(uc001zvj.3) ENST00000559667
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC30A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC30A4 (see all 101):
    hsa-miR-579 hsa-miR-3607-3p hsa-miR-15a hsa-miR-218-1* hsa-miR-134 hsa-miR-219-5p hsa-miR-30d hsa-miR-371-5p
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC30A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC30A4

    Additional mRNA sequence: 

    AF025409.1 AK290874.1 AY029482.1 BC026089.2 

    8 DOTS entries:

    DT.97835720  DT.95136564  DT.443823  DT.100748106  DT.100748107  DT.95333002  DT.97825667  DT.97835719 

    Selected AceView cDNA sequences (see all 29):

    AW297173 AA485220 NM_013309 BX101424 BC026089 BM129148 AW968543 AA489711 
    BM128883 BE835291 AY029482 BG720955 BI460231 AF025409 BF196341 BQ372441 
    BG724286 BM789500 AA484943 BX100461 CF140206 AI125381 CF142277 BE004188 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC30A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGATTCC
    SLC30A4 Expression
    About this image

    SLC30A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC30A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162989
        Pathway & Disease-focused RT2 Profiler PCR Array including SLC30A4: 
              Polycomb & Trithorax Target Genes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC30A4 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a41 , 5 solute carrier family 30 (zinc transporter), member more1, 5 88.76(n)1
    92.27(a)1
      2 (60.65 cM)5
    227851  NM_011774.21  NP_035904.21 
     1226812335 
    chicken
    (Gallus gallus)
    Aves SLC30A41 solute carrier family 30 (zinc transporter), member more 73.59(n)
    77.09(a)
      415444  XM_003641851.2  XP_003641899.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A46
    solute carrier family 30 (zinc transporter), membe...
    78(a)
    1 ↔ 1
    GL343506.1(1588-7895)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc30a41 solute carrier family 30 (zinc transporter), member more 68.48(n)
    68.15(a)
      100124729  NM_001102711.1  NP_001096181.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc642152 hypothetical protein MGC64215 69.87(n)   393616  BC057442.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111636
    --
    24(a)
    many ↔ many
    2R(1662279-1670360)
    worm
    (Caenorhabditis elegans)
    Secernentea Y39E4A.2a3   -- 40(a)
    (best of 3)
      III(13024489-13038276)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMT1(YMR177W)4 Putative metal transporter involved in mitochondrial more   --   13(616566-618098) 855215  NP_013902.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MTPB11 MTPB1 46.79(n)
    34.62(a)
      817490  NM_128495.3  NP_180502.2 


    ENSEMBL Gene Tree for SLC30A4 (if available)
    TreeFam Gene Tree for SLC30A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC30A4 gene
    SLC30A32  SLC30A22  SLC30A82  SLC30A102  SLC30A12  
    4 SIMAP similar genes for SLC30A4 using alignment to 1 protein entry:     ZNT4_HUMAN:
    ZNT4    SLC30A2    SLC30A3    SLC30A8

    Find genes that share paralogs with SLC30A4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC30A4 (see all 456)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846105551,2
    --22639908(+) ATGGCA/GCGATA 1 -- int10--------
    rs1890220791,2
    --22639964(+) CCCTCA/GGCCTC 1 -- int10--------
    rs1438404041,2
    C--22640004(+) ACCACA/GCCTGG 1 -- int10--------
    rs711143471,2
    C--45774256(-) AAATCT/-TTTTT 1 -- ds50011Minor allele frequency- -:0.00NA 2
    rs1891596621,2
    --45774430(+) GGGCAA/CCATGG 1 -- ds50010--------
    rs1815545011,2
    --45774760(+) AGATAG/TAAAAA 1 -- ut310--------
    rs1860425281,2
    --45774838(+) TCCAGA/TTGTCC 1 -- ut310--------
    rs1904536381,2
    --45774909(+) ATAGTC/TTATAT 1 -- ut310--------
    rs11369681,2
    C,F,H--45775125(+) gatacT/Cacagg 1 -- ut313Minor allele frequency- C:0.02NS NA 286
    rs1813965561,2
    --45775261(+) ACAGGC/TATGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC30A4 (45771809 - 45815005 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for SLC30A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519435CNV Loss19592680
    nsv1523CNV Loss18451855
    nsv904188CNV Gain21882294
    nsv469721CNV Complex16826518

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602095    OMIM disorders: --

    4 diseases for SLC30A4:    
    About MalaCards
    acrodermatitis enteropathica    enteropathica    acrodermatitis    autism spectrum disorder

    1 disease from the University of Copenhagen DISEASES database for SLC30A4:
    Acrodermatitis enteropathica

    Find genes that share disorders with SLC30A4           About GenesLikeMe

    1 Novoseek inferred disease relationship for SLC30A4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acrodermatitis enteropathica 94.2 3 11935329 (1), 12699353 (1), 11686514 (1)

    Genetic Association Database (GAD): SLC30A4
    Human Genome Epidemiology (HuGE) Navigator: SLC30A4 (4 documents)

    Export disorders for SLC30A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC30A4 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with SLC30A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    2. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    5. A novel gene involved in zinc transport is deficient in the lethal milk mouse. (PubMed id 9354792)1, 2 Huang L. and Gitschier J. (Nat. Genet. 1997)
    6. Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. (PubMed id 11686514)1, 9 Bleck O....McGrath J.A. (Arch. Dermatol. Res. 2001)
    7. Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. (PubMed id 19371353)1, 9 Lyubartseva G....Lovell M.A. (Brain Pathol. 2010)
    8. Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk. (PubMed id 12743795)1, 9 Michalczyk A....Ackland M.L. (Hum. Genet. 2003)
    9. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. (PubMed id 16580781)1, 9 Smith J.L.... Lovell M.A. (Neuroscience 2006)
    10. Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. (PubMed id 11988082)1, 9 Michalczyk A.A....Ackland M.L. (Biochem. J. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7782 HGNC: 11015 AceView: SLC30A4 Ensembl:ENSG00000104154 euGenes: HUgn7782
    ECgene: SLC30A4 H-InvDB: SLC30A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC30A4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC30A4 gene:
    Search GeneIP for patents involving SLC30A4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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