Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC30A4 Gene

Aliases for SLC30A4 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 4 2 3
  • ZNT4 3 4 6
  • Solute Carrier Family 30 Member 4 3 4
  • ZnT-4 3 4
  • Zinc Transporter 4 3

External Ids for SLC30A4 Gene

Previous Symbols for SLC30A4 Gene

  • ZNT4

Summaries for SLC30A4 Gene

Entrez Gene Summary for SLC30A4 Gene

  • Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC30A4 Gene

SLC30A4 (Solute Carrier Family 30 (Zinc Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC30A4 include acrodermatitis enteropathica and enteropathica. GO annotations related to this gene include zinc ion transmembrane transporter activity. An important paralog of this gene is SLC30A1.

UniProtKB/Swiss-Prot for SLC30A4 Gene

  • Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment

Gene Wiki entry for SLC30A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A4 Gene

Genomics for SLC30A4 Gene

Genomic Location for SLC30A4 Gene

Start:
45,479,611 bp from pter
End:
45,522,807 bp from pter
Size:
43,197 bases
Orientation:
Minus strand

Genomic View for SLC30A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A4 Gene

Regulatory Elements for SLC30A4 Gene

Proteins for SLC30A4 Gene

  • Protein details for SLC30A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14863-ZNT4_HUMAN
    Recommended name:
    Zinc transporter 4
    Protein Accession:
    O14863
    Secondary Accessions:
    • Q8TC39

    Protein attributes for SLC30A4 Gene

    Size:
    429 amino acids
    Molecular mass:
    47483 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC30A4 Gene

Proteomics data for SLC30A4 Gene at MOPED

Post-translational modifications for SLC30A4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A4 Gene

Domains for SLC30A4 Gene

Gene Families for SLC30A4 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A4 Gene

Suggested Antigen Peptide Sequences for SLC30A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14863

UniProtKB/Swiss-Prot:

ZNT4_HUMAN
Domain:
  • Contains a histidine-rich region which is a ligand for zinc and an aspartate-rich region which is a potential ligand for zinc.:
    • O14863
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.:
    • O14863
genes like me logo Genes that share domains with SLC30A4: view

Function for SLC30A4 Gene

Molecular function for SLC30A4 Gene

UniProtKB/Swiss-Prot Function: Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment

Gene Ontology (GO) - Molecular Function for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS 9354792
GO:0008324 cation transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC30A4: view
genes like me logo Genes that share phenotypes with SLC30A4: view

miRNA for SLC30A4 Gene

miRTarBase miRNAs that target SLC30A4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A4 Gene

Localization for SLC30A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A4 Gene

Endosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A4 Gene COMPARTMENTS Subcellular localization image for SLC30A4 gene
Compartment Confidence
endosome 5
plasma membrane 3
golgi apparatus 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005770 late endosome IDA 17349999
GO:0010008 endosome membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A4: view

Pathways for SLC30A4 Gene

SuperPathways for SLC30A4 Gene

No Data Available

Interacting Proteins for SLC30A4 Gene

Gene Ontology (GO) - Biological Process for SLC30A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0009636 response to toxic substance IDA 17575980
GO:0055069 zinc ion homeostasis IEA --
GO:0055085 transmembrane transport --
GO:0061088 regulation of sequestering of zinc ion IDA 17349999
genes like me logo Genes that share ontologies with SLC30A4: view

No data available for Pathways by source for SLC30A4 Gene

Compounds for SLC30A4 Gene

(1) Novoseek inferred chemical compound relationships for SLC30A4 Gene

Compound -log(P) Hits PubMed IDs
zinc 61.8 10
genes like me logo Genes that share compounds with SLC30A4: view

Transcripts for SLC30A4 Gene

mRNA/cDNA for SLC30A4 Gene

Unigene Clusters for SLC30A4 Gene

Solute carrier family 30 (zinc transporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A4 Gene

No ASD Table

Relevant External Links for SLC30A4 Gene

GeneLoc Exon Structure for
SLC30A4
ECgene alternative splicing isoforms for
SLC30A4

Expression for SLC30A4 Gene

mRNA expression in normal human tissues for SLC30A4 Gene

mRNA differential expression in normal tissues according to GTEx for SLC30A4 Gene

This gene is overexpressed in Prostate (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A4 Gene

SOURCE GeneReport for Unigene cluster for SLC30A4 Gene Hs.162989

genes like me logo Genes that share expressions with SLC30A4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for SLC30A4 Gene

Orthologs for SLC30A4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A4 35
  • 99.69 (n)
  • 99.3 (a)
SLC30A4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A4 35
  • 93.07 (n)
  • 94.39 (a)
SLC30A4 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A4 35
  • 94.24 (n)
  • 95.09 (a)
SLC30A4 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a4 35
  • 88.76 (n)
  • 92.27 (a)
Slc30a4 16
Slc30a4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A4 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a4 35
  • 86.89 (n)
  • 90.85 (a)
chicken
(Gallus gallus)
Aves SLC30A4 35
  • 73.59 (n)
  • 77.09 (a)
SLC30A4 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A4 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a4 35
  • 68.48 (n)
  • 68.15 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a4 35
  • 57.21 (n)
  • 61.94 (a)
slc30a4 36
  • 53 (a)
OneToOne
zgc64215 35
fruit fly
(Drosophila melanogaster)
Insecta CG11163 36
  • 24 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ttm-1 36
  • 32 (a)
ManyToMany
T18D3.3 37
  • 39 (a)
Y39E4A.2b 37
  • 40 (a)
Y39E4A.2a 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 20 (a)
ManyToMany
MMT1 38
ZRC1 36
  • 19 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MTPB1 35
  • 46.79 (n)
  • 34.62 (a)
Species with no ortholog for SLC30A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A4 Gene

ENSEMBL:
Gene Tree for SLC30A4 (if available)
TreeFam:
Gene Tree for SLC30A4 (if available)

Paralogs for SLC30A4 Gene

Paralogs for SLC30A4 Gene

Selected SIMAP similar genes for SLC30A4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC30A4: view

Variants for SLC30A4 Gene

Sequence variations from dbSNP and Humsavar for SLC30A4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs950027 -- 45,508,837(+) ATTTA(C/T)GAAGA intron-variant
rs1136967 -- 45,482,889(+) tgggc(C/T)aaagc utr-variant-3-prime
rs1136968 -- 45,482,927(+) gatac(C/T)acagg utr-variant-3-prime
rs1153829 -- 45,485,146(+) GGAGT(C/T)CCCAA utr-variant-3-prime
rs1529353 -- 45,493,428(-) AATAT(A/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A4 Gene

Variant ID Type Subtype PubMed ID
nsv469721 CNV Complex 16826518
nsv1523 CNV Loss 18451855
nsv519435 CNV Loss 19592680
nsv904188 CNV Gain 21882294

Relevant External Links for SLC30A4 Gene

HapMap Linkage Disequilibrium report
SLC30A4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A4 Gene

Disorders for SLC30A4 Gene

(1) University of Copenhagen DISEASES for SLC30A4 Gene

(1) Novoseek inferred disease relationships for SLC30A4 Gene

Disease -log(P) Hits PubMed IDs
acrodermatitis enteropathica 94.2 3

Relevant External Links for SLC30A4

Genetic Association Database (GAD)
SLC30A4
Human Genome Epidemiology (HuGE) Navigator
SLC30A4
genes like me logo Genes that share disorders with SLC30A4: view

No data available for UniProtKB/Swiss-Prot for SLC30A4 Gene

Publications for SLC30A4 Gene

  1. Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. (PMID: 11686514) Bleck O. … McGrath J.A. (Arch. Dermatol. Res. 2001) 3 23
  2. ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families. (PMID: 11935329) Nakano A. … Uitto J. (Hum. Genet. 2002) 3 23
  3. Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. (PMID: 11988082) Michalczyk A.A. … Ackland M.L. (Biochem. J. 2002) 3 23
  4. Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk. (PMID: 12743795) Michalczyk A. … Ackland M.L. (Hum. Genet. 2003) 3 23
  5. Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. (PMID: 16580781) Smith J.L. … Lovell M.A. (Neuroscience 2006) 3 23

Products for SLC30A4 Gene

  • antibodies-online proteins for SLC30A4
  • antibodies-online antibodies for SLC30A4
  • antibodies-online kits for SLC30A4

Sources for SLC30A4 Gene

Back to Top

Content