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Aliases for SLC30A3 Gene

Aliases for SLC30A3 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 3 2 3
  • Solute Carrier Family 30 Member 3 3 4
  • ZnT-3 3 4
  • ZNT3 3 4
  • Zinc Transporter ZnT-3 3

External Ids for SLC30A3 Gene

Previous HGNC Symbols for SLC30A3 Gene

  • ZNT3

Previous GeneCards Identifiers for SLC30A3 Gene

  • GC02M027398
  • GC02M027570
  • GC02M027452
  • GC02M027454
  • GC02M027388
  • GC02M027330
  • GC02M027476

Summaries for SLC30A3 Gene

GeneCards Summary for SLC30A3 Gene

SLC30A3 (Solute Carrier Family 30 (Zinc Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include cation transmembrane transporter activity and zinc transporting ATPase activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A3 Gene

  • Involved in accumulation of zinc in synaptic vesicles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A3 Gene

Genomics for SLC30A3 Gene

Regulatory Elements for SLC30A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A3 Gene

Chromosome:
2
Start:
27,253,684 bp from pter
End:
27,275,817 bp from pter
Size:
22,134 bases
Orientation:
Minus strand

Genomic View for SLC30A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A3 Gene

Proteins for SLC30A3 Gene

  • Protein details for SLC30A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99726-ZNT3_HUMAN
    Recommended name:
    Zinc transporter 3
    Protein Accession:
    Q99726
    Secondary Accessions:
    • Q8TC03

    Protein attributes for SLC30A3 Gene

    Size:
    388 amino acids
    Molecular mass:
    41945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC30A3 Gene

Proteomics data for SLC30A3 Gene at MOPED

Post-translational modifications for SLC30A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A3 Gene

Antibody Products

No data available for DME Specific Peptides for SLC30A3 Gene

Domains & Families for SLC30A3 Gene

Gene Families for SLC30A3 Gene

Protein Domains for SLC30A3 Gene

Suggested Antigen Peptide Sequences for SLC30A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99726

UniProtKB/Swiss-Prot:

ZNT3_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A3: view

Function for SLC30A3 Gene

Molecular function for SLC30A3 Gene

UniProtKB/Swiss-Prot Function:
Involved in accumulation of zinc in synaptic vesicles.

Gene Ontology (GO) - Molecular Function for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity --
GO:0015633 zinc transporting ATPase activity TAS 8962159
genes like me logo Genes that share ontologies with SLC30A3: view
genes like me logo Genes that share phenotypes with SLC30A3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A3 Gene

Localization for SLC30A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A3 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A3 Gene COMPARTMENTS Subcellular localization image for SLC30A3 gene
Compartment Confidence
endosome 4
plasma membrane 4
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome TAS 8962159
GO:0005770 late endosome IDA 17349999
GO:0005887 integral component of plasma membrane TAS 8962159
genes like me logo Genes that share ontologies with SLC30A3: view

Pathways & Interactions for SLC30A3 Gene

genes like me logo Genes that share pathways with SLC30A3: view

Gene Ontology (GO) - Biological Process for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8962159
GO:0006812 cation transport --
GO:0010043 response to zinc ion IBA --
GO:0051050 positive regulation of transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with SLC30A3: view

No data available for SIGNOR curated interactions for SLC30A3 Gene

Drugs & Compounds for SLC30A3 Gene

(1) Drugs for SLC30A3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with SLC30A3: view

Transcripts for SLC30A3 Gene

Unigene Clusters for SLC30A3 Gene

Solute carrier family 30 (zinc transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: -
SP6: -
SP7:

Relevant External Links for SLC30A3 Gene

GeneLoc Exon Structure for
SLC30A3
ECgene alternative splicing isoforms for
SLC30A3

Expression for SLC30A3 Gene

mRNA expression in normal human tissues for SLC30A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC30A3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.4), Brain - Cortex (x9.1), Testis (x8.1), Brain - Anterior cingulate cortex (BA24) (x6.8), and Brain - Amygdala (x6.6).

Protein differential expression in normal tissues from HIPED for SLC30A3 Gene

This gene is overexpressed in Frontal cortex (24.0), Brain (22.6), and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A3 Gene



SOURCE GeneReport for Unigene cluster for SLC30A3 Gene Hs.467981

genes like me logo Genes that share expression patterns with SLC30A3: view

Protein tissue co-expression partners for SLC30A3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A3 Gene

Orthologs for SLC30A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A3 35
  • 89.43 (n)
  • 92.01 (a)
SLC30A3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A3 35
  • 92.01 (n)
  • 93.04 (a)
SLC30A3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a3 35
  • 86.43 (n)
  • 89.18 (a)
Slc30a3 16
Slc30a3 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A3 35
  • 99.4 (n)
  • 100 (a)
SLC30A3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a3 35
  • 85.14 (n)
  • 86.6 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A3 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497671 35
  • 66.31 (n)
  • 56.49 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a2 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BG:DS07295.1 37
  • 33 (a)
CG31860 35
  • 51.02 (n)
  • 43.73 (a)
CG31860 36
  • 22 (a)
ManyToMany
ZnT35C 36
  • 31 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea T18D3.3 37
  • 41 (a)
Y39E4A.2a 37
  • 38 (a)
Y39E4A.2b 37
  • 38 (a)
cdf-2 36
  • 39 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 20 (a)
ManyToMany
ZRC1 36
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MTPA1 35
  • 47.63 (n)
  • 37.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for SLC30A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A3 Gene

ENSEMBL:
Gene Tree for SLC30A3 (if available)
TreeFam:
Gene Tree for SLC30A3 (if available)

Paralogs for SLC30A3 Gene

Paralogs for SLC30A3 Gene

(4) SIMAP similar genes for SLC30A3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SLC30A3: view

Variants for SLC30A3 Gene

Sequence variations from dbSNP and Humsavar for SLC30A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1132986 -- 27,254,587(-) ATAAA(C/G)TTGTG utr-variant-3-prime
rs1975383 -- 27,254,124(+) GGCTG(C/G)TATCA downstream-variant-500B
rs1992290 -- 27,258,784(+) AAGCA(A/C)ACGGC synonymous-codon, reference, missense
rs3820830 -- 27,254,608(+) GCAGC(A/G)GAGTC utr-variant-3-prime, downstream-variant-500B
rs6547521 -- 27,265,564(+) CAAGT(C/G)CAAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC30A3 Gene

Variant ID Type Subtype PubMed ID
nsv833603 CNV Loss 17160897
nsv873754 CNV Loss 21882294

Variation tolerance for SLC30A3 Gene

Residual Variation Intolerance Score: 92.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A3 Gene

HapMap Linkage Disequilibrium report
SLC30A3
Human Gene Mutation Database (HGMD)
SLC30A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A3 Gene

Disorders for SLC30A3 Gene

Relevant External Links for SLC30A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A3
genes like me logo Genes that share disorders with SLC30A3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A3 Gene

Publications for SLC30A3 Gene

  1. ZnT-3, a putative transporter of zinc into synaptic vesicles. (PMID: 8962159) Palmiter R.D. … Findley S.D. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 23 67
  2. The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport. (PMID: 20006607) Suphioglu C. … Ackland M.L. (FEBS Lett. 2010) 23 67
  3. Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein. (PMID: 20053882) GrA … Jahn R. (J. Neurosci. 2010) 23 67
  4. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. (PMID: 19521526) Salazar G. … Faundez V. (PLoS ONE 2009) 23 67
  5. ZnT3 mRNA levels are reduced in Alzheimer's disease post-mortem brain. (PMID: 20030848) Beyer N. … Johnston J.A. (Mol Neurodegener 2009) 23 67

Products for SLC30A3 Gene

Sources for SLC30A3 Gene

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