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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC30A3 Gene

protein-coding   GIFtS: 53
GCID: GC02M027476

solute carrier family 30 (zinc transporter), member 3


(Previous symbol: ZNT3)
 Explore 4 diseases affiliated with
SLC30A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC30A3    

Aliases
for SLC30A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 31 2     Zinc Transporter ZnT-32
ZNT31 2 3 5     ZnT-33
Solute Carrier Family 30 Member 32 3     ZnT-33
Zinc Transporter 32     

External Ids:    HGNC: 110141   Entrez Gene: 77812   Ensembl: ENSG000001151947   OMIM: 6028785   UniProtKB: Q997263   

Export aliases for SLC30A3 gene to outside databases

Previous GC identifers: GC02M027398 GC02M027570 GC02M027452 GC02M027454 GC02M027388 GC02M027330 GC02M027219


Summaries
for SLC30A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726
Function: Involved in accumulation of zinc in synaptic vesicles (By similarity)




Genomic Views
for SLC30A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022184.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC30A3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Bach2   Nkx2-5   E2F-2   LCR-F1   Arnt   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC30A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC30A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

SLC30A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027476:  view genomic region     (about GC identifiers)

Start:
 27,476,552 bp from pter      End:
 27,498,685 bp from pter
Size:
 22,134 bases      Orientation:
 minus strand

Proteins
for SLC30A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726 (See protein sequence)
Recommended Name: Zinc transporter 3  
Size: 388 amino acids; 41945 Da
Subcellular location: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein
(Probable). Cell junction, synapse, synaptosome (By similarity)
Secondary accessions: Q8TC03

Explore the universe of human proteins at neXtProt for SLC30A3: NX_Q99726

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q99726

    • SLC30A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003450.2  
    ENSEMBL proteins: 
     ENSP00000233535   ENSP00000388219   ENSP00000414320   ENSP00000393545   ENSP00000403959  
     ENSP00000403912   ENSP00000392673   ENSP00000415226  
    Reactome Protein details: Q99726
    Human Recombinant Protein Products: 
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    OriGene Purified Protein: SLC30A3
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    Novus Biologicals SLC30A3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC30A3

    Gene Ontology (GO): 5/12 cellular component terms (GO ID links to tree view) (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IDA17349999
    GO:0005768endosome TAS8962159
    GO:0005770late endosome IDA17349999
    GO:0005887integral to plasma membrane TAS8962159


    SLC30A3 for ontologies           About GeneDecksing



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    Uscn Antibodies for SLC30A3
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    Assay Products for SLC30A3: 
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    Uscn ELISAs and CLIAs for SLC30A3

    Protein Domains /
    Families
    for SLC30A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC30A3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q99726

    ProtoNet protein and cluster: Q99726

    1 Blocks protein family: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    Function
    for SLC30A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726
    Function: Involved in accumulation of zinc in synaptic vesicles (By similarity)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A3
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A3 (see all 34):
    hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-29a hsa-miR-449a hsa-miR-9 hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: SLC30A3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC30A3 (see all 7)
    OriGene shRNA RFP: SLC30A3
    OriGene siRNA: SLC30A3
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    Gene Editing
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A3 

    Cell Line
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    Search LifeMap BioReagents cell lines for SLC30A3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A3

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity ----
    GO:0015633zinc transporting ATPase activity TAS8962159


    SLC30A3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC30A3:
     Synthetic lethal with Ras 

    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Slc30a3):
     homeostasis/metabolism  nervous system  other 

    SLC30A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC30A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Zinc transporters
    		Zinc transporters1.00
    		Zinc efflux and compartmentalization by the SLC30 family0.41
    		Metal ion SLC transporters0.68

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for SLC30A3 (see all 6)
        Zinc efflux and compartmentalization by the SLC30 family
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters



    SLC30A3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC30A3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for SLC30A3 (Q997263 ENSP000002335354) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3B1O002033, ENSP000002551944I2D: score=3 STRING: ENSP00000255194
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    AP3S1Q925723, ENSP000003253694I2D: score=2 STRING: ENSP00000325369
    YWHABP319463I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8962159
    GO:0051050positive regulation of transport IEA--
    GO:0055085transmembrane transport TAS--
    GO:0061088regulation of sequestering of zinc ion IDA17349999


    SLC30A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC30A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC30A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC30A3
    1 Novoseek chemical compound relationship for SLC30A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.5 43 15860731 (6), 8962159 (3), 14662799 (3), 19521526 (2) (see all 12)

    Search CenterWatch for drugs/clinical trials and news about SLC30A3 / ZNT3 

    Transcripts
    for SLC30A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC30A3 gene: 
    NM_003459.4  

    Unigene Cluster for SLC30A3:

    Solute carrier family 30 (zinc transporter), member 3
    Hs.467981  [show with all ESTs]
    Unigene Representative Sequence: AK127300
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497341(uc002rjj.3) ENST00000482990 ENST00000233535(uc002rjk.3 uc010ylh.2)
    ENST00000445870 ENST00000432351 ENST00000426924 ENST00000424577 ENST00000486309
    ENST00000450118 ENST00000426569 ENST00000447008

    miRNA
    Products:             		 OriGene 3'-UTR Clone: SLC30A3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A3
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A3 (see all 34):
    hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-29a hsa-miR-449a hsa-miR-9 hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmid: SLC30A3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC30A3 (see all 7)
    OriGene shRNA RFP: SLC30A3
    OriGene siRNA: SLC30A3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A3
    Clone
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    GenScript: all cDNA clones in your preferred vector: SLC30A3 (NM_003459)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A3 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A3

    Additional cDNA sequence: 

    AK127096.1 AK127300.1 AK302174.1 AK313600.1 BC028358.2 U76010.1 

    7 DOTS entries:

    DT.455877  DT.100648846  DT.101975540  DT.75189631  DT.97762692  DT.97803202  DT.91740278 

    24/33 AceView cDNA sequences (see all 33):

    BC028358 BI754180 AK127096 AK127300 BU633568 BP369010 BM554028 NM_003459 
    CR605101 AL046404 BM552602 BM560506 BX349088 U76010 BM925306 BM909692 
    AL580043 BM551613 BX283698 BI520363 CA423384 BG772695 AL558140 AA621201 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -     -                 -                             -                       -         
    SP2:        -     -     -     -                 -                                                               
    SP3:                    -     -                 -           -     -     -     -                                 
    SP4:                          -     -           -                                                               
    SP5:                                                                                                  -         


    ECgene alternative splicing isoforms for SLC30A3

    Expression
    for SLC30A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC30A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC30A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyAfferent ArterioleJuxtaglomerular CellsKidney, Smooth Muscle
    Spinal CordSpinal Dorsal ColumnsDorsal Spinal Cord Progenitor CellsSpinal Cord
    Spinal CordSpinal Ventral ColumnsVentral Spinal Cord Progenitor CellsMotor Neurons
    BrainHypothalamusBrain
    BrainMedulla OblongataBrain
    Neural TubeMetencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Spinal CordSpinal Dorsal ColumnsSpinal Cord
    Spinal CordSpinal Ventral ColumnsSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC30A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC30A3

    SOURCE GeneReport for Unigene cluster: Hs.467981
        SABiosciences Custom PCR Arrays for SLC30A3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A3

    Orthologs
    for SLC30A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC30A3 gene from 7/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia SLC30A36
    		 --
    		 54(a)
    		 1 ↔ 1
    		 AAWZ02035537(33820-39725)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc30a26
    		 solute carrier family 30 (zinc transporter), membe...
    		 49(a)
    		 1 ↔ 1
    		 20(38620726-38642219)
    fruit fly
    (Drosophila melanogaster)    		 Insecta BG:DS07295.13 heavy metal ion porter 33(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea T18D3.33 cobalt uptake like protein 41(a)
    (best of 3)    		   X(12499995-12502401)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons MTPA16
    ATMTP16
    (see all 4)    		 metal tolerance protein 1 short form
    (see all 4)    		 33(a)
    30(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 3(22937170-22938574)
    2(19237434-19239405)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 cation efflux family protein, putative, expressed
    		 28(a)
    		 1 → many
    		 5(1675472-1679040)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria zitB6
    		 zinc efflux system
    		 30(a)
    		 1 → many
    		 Chromosome(783105-784046)


    ENSEMBL Gene Tree for SLC30A3 (if available)
    TreeFam Gene Tree for SLC30A3 (if available) 

    Paralogs
    for SLC30A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC30A3 gene
    SLC30A22  SLC30A82  SLC30A102  SLC30A12  SLC30A42  
    4 SIMAP similar genes for SLC30A3 using alignment to 8 protein entries:     ZNT3_HUMAN (see all proteins):
    SLC30A8    SLC30A4    ZNT4    SLC30A2

    SLC30A3 for paralogs           About GeneDecksing



    Genomic Variants
    for SLC30A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/177 NCBI SNPs in SLC30A3 are shown (see all 177)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs19753831,2
    		C,--27476992(+) GGCTGC/GTATCA 1 -- ds50014Minor allele frequency- G:0.07MN NA WA 306
    rs1886601721,2
    		--27477238(+) AGGACC/GCAGGC 1 -- ds50010--------
    rs1510870251,2
    		--27477302(+) TCTGAA/GGGTGG 1 -- ds50010--------
    rs2003650371,2
    		--27477425(+) CAGCA-/CCACAG 1 -- ds50010--------
    rs1410147031,2
    		--27477428(+) GCACAC/TAGGCT 1 -- ds50010--------
    rs38208301,2
    		C,F,H,--27477476(+) GCAGCG/AGAGTC 1 -- ut31 ese39Minor allele frequency- A:0.05NS EA 1230
    rs1465044301,2
    		--27477539(+) ATAGAA/CCCCCA 1 -- ut310--------
    rs1145673111,2
    		C,F,--27477547(+) CCAAAC/TAGACA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1390700201,2
    		--27477605(+) CAGAGA/GCACAC 1 -- ut310--------
    rs1929638021,2
    		--27477655(+) ACACAA/CACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC30A3 (27476552 - 27498685 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC30A3: --
    Human Gene Mutation Database (HGMD): SLC30A3

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    Disorders / Diseases
    for SLC30A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC30A3 for disorders           About GeneDecksing

    OMIM gene information: 602878    OMIM disorders: --

    4 diseases for SLC30A3:    About MalaCards
    borna disease    alzheimer's disease    malaria    neuronitis


    Export disorders for SLC30A3 gene to outside databases

    Publications
    for SLC30A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC30A3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with SLC30A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ZnT-3, a putative transporter of zinc into synaptic vesicles. (PubMed id 8962159)1, 2, 3, 9 Palmiter R.D.... Findley S.D. (1996)
    2. SLC30A3 (ZnT3) oligomerization by dityrosine bonds re gulates its subcellular localization and metal transport capacity. (PubMed id 19521526)1, 9 Salazar G....Faundez V. (2009)
    3. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. (PubMed id 14657250)1, 9 Salazar G....Faundez V. (2004)
    4. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. (PubMed id 14662799)1, 9 Iguchi K....Hirano K. (2004)
    5. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PubMed id 17349999)1, 9 Falcon-Perez J.M. and Dell'Angelica E.C. (2007)
    6. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. (PubMed id 18639746)1 Zhang L.H....Wang Z.Y. (2008)
    7. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. (PubMed id 17971500)1 Overbeck S.... Rink L. (2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PubMed id 15154973)1 Seve M.... Favier A. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    External Searches for SLC30A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing SLC30A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7781 HGNC: 11014 AceView: SLC30A3 Ensembl:ENSG00000115194 euGenes: HUgn7781
    ECgene: SLC30A3 H-InvDB: SLC30A3

    Other Databases showing SLC30A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC30A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC30A3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for SLC30A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC30A3 gene:
    Search GeneIP for patents involving SLC30A3

    GeneCards and IP:
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