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SLC30A3 Gene

protein-coding   GIFtS: 55
GCID: GC02M027476

Solute Carrier Family 30 (Zinc Transporter), Member 3


(Previous symbol: ZNT3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 31 2     Zinc Transporter ZnT-32
ZNT31 2 3 5     znT-32
Solute Carrier Family 30 Member 32 3     ZnT-33
Zinc Transporter 32     

External Ids:    HGNC: 110141   Entrez Gene: 77812   Ensembl: ENSG000001151947   OMIM: 6028785   UniProtKB: Q997263   

Export aliases for SLC30A3 gene to outside databases

Previous GC identifers: GC02M027398 GC02M027570 GC02M027452 GC02M027454 GC02M027388 GC02M027330 GC02M027219


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC30A3 Gene:
SLC30A3 (solute carrier family 30 (zinc transporter), member 3) is a protein-coding gene. GO annotations related to this gene include zinc transporting ATPase activity. An important paralog of this gene is SLC30A2.

UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726
Function: Involved in accumulation of zinc in synaptic vesicles (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A3 gene promoter:
         E2F-4   E2F-3a   E2F-5   Bach2   Nkx2-5   E2F-2   LCR-F1   Arnt   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A3 promoter sequence
   Search Chromatin IP Primers for SLC30A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

SLC30A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M027476:  view genomic region     (about GC identifiers)

Start:
27,476,552 bp from pter      End:
27,498,685 bp from pter
Size:
22,134 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726 (See protein sequence)
Recommended Name: Zinc transporter 3  
Size: 388 amino acids; 41945 Da
Secondary accessions: Q8TC03

Explore the universe of human proteins at neXtProt for SLC30A3: NX_Q99726

Explore proteomics data for SLC30A3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC30A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003450.2  
    ENSEMBL proteins: 
     ENSP00000233535   ENSP00000388219   ENSP00000414320   ENSP00000393545   ENSP00000403959  
     ENSP00000403912   ENSP00000392673   ENSP00000415226  
    Reactome Protein details: Q99726

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    Cloud-Clone Corp. Proteins for SLC30A3

     
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    antibodies-online peptides for SLC30A3

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    antibodies-online antibodies for SLC30A3 (28 products) 

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    antibodies-online kits for SLC30A3 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 3
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q99726

    ProtoNet protein and cluster: Q99726

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT3_HUMAN, Q99726
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    Find genes that share domains with SLC30A3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT3_HUMAN, Q99726
    Function: Involved in accumulation of zinc in synaptic vesicles (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity ----
    GO:0015633zinc transporting ATPase activity TAS8962159
         
    Find genes that share ontologies with SLC30A3           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC30A3:
     Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc30a3):
     homeostasis/metabolism  nervous system  other 

    Find genes that share phenotypes with SLC30A3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for SLC30A3

    miRNA
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    Block miRNA regulation of human, mouse, rat SLC30A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC30A3 (see all 34):
    hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-29a hsa-miR-449a hsa-miR-9 hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: SLC30A3 (NM_003459)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNT3_HUMAN, Q99726: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane
    protein (Probable). Cell junction, synapse, synaptosome (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome4
    plasma membrane4
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17349999
    GO:0005768endosome TAS8962159
    GO:0005770late endosome IDA17349999
    GO:0005887integral component of plasma membrane TAS8962159
    GO:0008021synaptic vesicle TAS8962159

    Find genes that share ontologies with SLC30A3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC30A3 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc transporters0.00
    Zinc efflux and compartmentalization by the SLC30 family0.00


    Find genes that share SuperPaths with SLC30A3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC30A3
        Zinc efflux and compartmentalization by the SLC30 family


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC30A3
    Interactions:

        Search GeneGlobe Interaction Network for SLC30A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for SLC30A3 (Q997263 ENSP000002335354) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AP3B1O002033, ENSP000002551944I2D: score=3 STRING: ENSP00000255194
    AP3D1O146173, ENSP000003440554I2D: score=2 STRING: ENSP00000344055
    AP3S1Q925723, ENSP000003253694I2D: score=2 STRING: ENSP00000325369
    YWHABP319463I2D: score=1 
    MAPK3ENSP000002630254STRING: ENSP00000263025
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006810transport TAS8962159
    GO:0006812cation transport ----
    GO:0051050positive regulation of transport IEA--
    GO:0055085transmembrane transport TAS--
    GO:0061088regulation of sequestering of zinc ion IDA17349999

    Find genes that share ontologies with SLC30A3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC30A3 (ZNT3)

    1 Novoseek inferred chemical compound relationship for SLC30A3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.5 43 15860731 (6), 8962159 (3), 14662799 (3), 19521526 (2) (see all 12)



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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC30A3 gene: 
    NM_003459.4  

    Unigene Cluster for SLC30A3:

    Solute carrier family 30 (zinc transporter), member 3
    Hs.467981  [show with all ESTs]
    Unigene Representative Sequence: AK127300
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497341(uc002rjj.3) ENST00000482990 ENST00000233535(uc002rjk.3 uc010ylh.2)
    ENST00000445870 ENST00000432351 ENST00000426924 ENST00000424577 ENST00000486309
    ENST00000450118 ENST00000426569 ENST00000447008
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC30A3 (see all 34):
    hsa-miR-642a hsa-miR-3194-5p hsa-miR-106a hsa-miR-29a hsa-miR-449a hsa-miR-9 hsa-miR-93 hsa-miR-133a
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A3 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC30A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC30A3

    Additional mRNA sequence: 

    AK127096.1 AK127300.1 AK302174.1 AK313600.1 BC028358.2 U76010.1 

    7 DOTS entries:

    DT.455877  DT.100648846  DT.101975540  DT.75189631  DT.97762692  DT.97803202  DT.91740278 

    Selected AceView cDNA sequences (see all 33):

    BC028358 AK127300 BI754180 CR605101 BM554028 BU633568 BP369010 AK127096 
    NM_003459 BM909692 AL580043 BM925306 BM552602 BX349088 BX283698 BM551613 
    BG772695 CA423384 BI520363 BM560506 AL046404 U76010 AL558140 AA621201 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A3 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                    -     -                 -                             -                       -         
    SP2:        -     -     -     -                 -                                                               
    SP3:                    -     -                 -           -     -     -     -                                 
    SP4:                          -     -           -                                                               
    SP5:                                                                                                  -         


    ECgene alternative splicing isoforms for SLC30A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC30A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC30A3 Expression
    About this image


    SLC30A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Medulla Oblongata
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Testis (Reproductive System)
    SLC30A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC30A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467981
        Custom PCR Arrays for SLC30A3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC30A3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a31 , 5 solute carrier family 30 (zinc transporter), member more1, 5 86.43(n)1
    89.18(a)1
      5 (16.97 cM)5
    227841  NM_011773.31  NP_035903.21 
     310861065 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A36
    solute carrier family 30 (zinc transporter), membe...
    59(a)
    1 ↔ 1
    AAWZ02035537(30352-43397)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004976711 zinc transporter 3-like 66.31(n)
    56.49(a)
      100497671  XM_002943383.2  XP_002943429.2 
    zebrafish
    (Danio rerio)
    Actinopterygii slc30a26
    solute carrier family 30 (zinc transporter), membe...
    50(a)
    1 ↔ 1
    20(38620644-38642475) ENSDARG00000021305
    fruit fly
    (Drosophila melanogaster)
    Insecta BG:DS07295.13
    CG318601
    heavy metal ion porter3
    CG318601
    33(a)3
    51.02(n)1
    43.73(a)1
      3261671  NM_164998.31  NP_723732.21 
    worm
    (Caenorhabditis elegans)
    Secernentea T18D3.33 cobalt uptake like protein 41(a)
    (best of 3)
      X(12499995-12502401)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COT16
    ZRC16
    Vacuolar transporter that mediates zinc transport ...
    Vacuolar membrane zinc transporter, transports zin...
    20(a)
    20(a)
    many ↔ many
    many ↔ many
    XV(906236-907555) YOR316C
    XIII(754838-756166) YMR243C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MTPA11 MTPA1 47.63(n)
    37.95(a)
      825367  NM_116059.2  NP_191753.1 


    ENSEMBL Gene Tree for SLC30A3 (if available)
    TreeFam Gene Tree for SLC30A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC30A3 gene
    SLC30A22  SLC30A82  SLC30A102  SLC30A12  SLC30A42  
    4 SIMAP similar genes for SLC30A3 using alignment to 8 protein entries:     ZNT3_HUMAN (see all proteins):
    SLC30A8    SLC30A4    ZNT4    SLC30A2

    Find genes that share paralogs with SLC30A3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC30A3 (see all 239)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs19753831,2
    C--27476992(+) GGCTGC/GTATCA 1 -- ds50014Minor allele frequency- G:0.07MN NA WA 306
    rs1886601721,2
    --27477238(+) AGGACC/GCAGGC 1 -- ds50010--------
    rs1510870251,2
    --27477302(+) TCTGAA/GGGTGG 1 -- ds50010--------
    rs2003650371,2
    C--27477425(+) CAGCA-/CCACAG 1 -- ds50010--------
    rs1410147031,2
    --27477428(+) GCACAC/TAGGCT 1 -- ds50010--------
    rs38208301,2
    C,F,H--27477476(+) GCAGCG/AGAGTC 1 -- ut31 ese39Minor allele frequency- A:0.05NS EA 1230
    rs1465044301,2
    --27477539(+) ATAGAA/CCCCCA 1 -- ut310--------
    rs1145673111,2
    C,F--27477547(+) CCAAAC/TAGACA 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1390700201,2
    C--27477605(+) CAGAGA/GCACAC 1 -- ut310--------
    rs1929638021,2
    --27477655(+) ACACAA/CACACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC30A3 (27476552 - 27498685 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC30A3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873754CNV Loss21882294
    nsv833603CNV Loss17160897

    Human Gene Mutation Database (HGMD): SLC30A3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A3
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602878    OMIM disorders: --


    Find genes that share disorders with SLC30A3           About GenesLikeMe


    Export disorders for SLC30A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC30A3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC30A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZnT-3, a putative transporter of zinc into synaptic vesicles. (PubMed id 8962159)1, 2, 3, 9 Palmiter R.D.... Findley S.D. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. (PubMed id 19521526)1, 9 Salazar G....Faundez V. (PLoS ONE 2009)
    3. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. (PubMed id 14657250)1, 9 Salazar G....Faundez V. (Mol. Biol. Cell 2004)
    4. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. (PubMed id 14662799)1, 9 Iguchi K....Hirano K. (J. Androl. 2004)
    5. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PubMed id 17349999)1, 9 FalcA^n-PAcrez J.M. and Dell'Angelica E.C. (Exp. Cell Res. 2007)
    6. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. (PubMed id 18639746)1 Zhang L.H....Wang Z.Y. (Brain Res. Bull. 2008)
    7. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. (PubMed id 17971500)1 Overbeck S.... Rink L. (J. Leukoc. Biol. 2008)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    9. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PubMed id 15154973)1 Seve M.... Favier A. (BMC Genomics 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7781 HGNC: 11014 AceView: SLC30A3 Ensembl:ENSG00000115194 euGenes: HUgn7781
    ECgene: SLC30A3 H-InvDB: SLC30A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC30A3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC30A3 gene:
    Search GeneIP for patents involving SLC30A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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