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Aliases for SLC30A3 Gene

Aliases for SLC30A3 Gene

  • Solute Carrier Family 30 Member 3 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 3 2 3
  • ZnT-3 3 4
  • ZNT3 3 4
  • Zinc Transporter ZnT-3 3
  • Zinc Transporter 3 3

External Ids for SLC30A3 Gene

Previous HGNC Symbols for SLC30A3 Gene

  • ZNT3

Previous GeneCards Identifiers for SLC30A3 Gene

  • GC02M027398
  • GC02M027570
  • GC02M027452
  • GC02M027454
  • GC02M027388
  • GC02M027330
  • GC02M027476

Summaries for SLC30A3 Gene

GeneCards Summary for SLC30A3 Gene

SLC30A3 (Solute Carrier Family 30 Member 3) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity and zinc-transporting ATPase activity. An important paralog of this gene is SLC30A2.

UniProtKB/Swiss-Prot for SLC30A3 Gene

  • Involved in accumulation of zinc in synaptic vesicles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A3 Gene

Genomics for SLC30A3 Gene

Regulatory Elements for SLC30A3 Gene

Enhancers for SLC30A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027169 1.3 Ensembl ENCODE 10.5 +104.5 104549 2.9 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF143 ZNF263 SP5 ZHX2 ATRAID GTF3C2 TCF23 PRR30 PREB SLC5A6 ABHD1 CAD DNAJC5G SLC30A3
GH02F027091 1.3 Ensembl ENCODE 10.2 +181.7 181703 7.0 CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 KHK EMILIN1 ABHD1 CGREF1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB
GH02F027279 0.9 ENCODE 0.8 -4.3 -4251 0.2 HDAC1 ATF1 ARNT ARID4B ZNF2 RAD21 GATA2 ZNF366 SCRT2 ZNF143 NRBP1 GTF3C2 GPN1 SLC30A3 TRIM54
GH02F027281 0.7 ENCODE 0.8 -4.7 -4694 0.2 ATF1 ESRRA RNF2 NR2F1 HLF ARID1B JUND SMARCA4 FOS NR2F6 SLC30A3 TRIM54
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC30A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A3 Gene

27,253,684 bp from pter
27,275,817 bp from pter
22,134 bases
Minus strand

Genomic View for SLC30A3 Gene

Genes around SLC30A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A3 Gene

Proteins for SLC30A3 Gene

  • Protein details for SLC30A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter 3
    Protein Accession:
    Secondary Accessions:
    • Q8TC03

    Protein attributes for SLC30A3 Gene

    388 amino acids
    Molecular mass:
    41945 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC30A3 Gene

Post-translational modifications for SLC30A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC30A3 Gene

Domains & Families for SLC30A3 Gene

Gene Families for SLC30A3 Gene

Protein Domains for SLC30A3 Gene

Suggested Antigen Peptide Sequences for SLC30A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A3: view

Function for SLC30A3 Gene

Molecular function for SLC30A3 Gene

UniProtKB/Swiss-Prot Function:
Involved in accumulation of zinc in synaptic vesicles.

Gene Ontology (GO) - Molecular Function for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
GO:0015633 zinc-transporting ATPase activity TAS 8962159
genes like me logo Genes that share ontologies with SLC30A3: view
genes like me logo Genes that share phenotypes with SLC30A3: view

Animal Models for SLC30A3 Gene

MGI Knock Outs for SLC30A3:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A3 Gene

Localization for SLC30A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A3 Gene

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC30A3 gene
Compartment Confidence
plasma membrane 5
endosome 5
lysosome 4
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005764 lysosome IEA --
GO:0005765 lysosomal membrane IEA --
GO:0005768 endosome TAS 8962159
GO:0005770 late endosome IDA 17349999
genes like me logo Genes that share ontologies with SLC30A3: view

Pathways & Interactions for SLC30A3 Gene

genes like me logo Genes that share pathways with SLC30A3: view

Gene Ontology (GO) - Biological Process for SLC30A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 8962159
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0010043 response to zinc ion IBA --
genes like me logo Genes that share ontologies with SLC30A3: view

No data available for SIGNOR curated interactions for SLC30A3 Gene

Drugs & Compounds for SLC30A3 Gene

(1) Drugs for SLC30A3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC30A3: view

Transcripts for SLC30A3 Gene

Unigene Clusters for SLC30A3 Gene

Solute carrier family 30 (zinc transporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - -
SP5: -
SP6: -

Relevant External Links for SLC30A3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC30A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC30A3 Gene

mRNA differential expression in normal tissues according to GTEx for SLC30A3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x9.4), Brain - Cortex (x9.1), Testis (x8.1), Brain - Anterior cingulate cortex (BA24) (x6.8), and Brain - Amygdala (x6.6).

Protein differential expression in normal tissues from HIPED for SLC30A3 Gene

This gene is overexpressed in Frontal cortex (24.0), Brain (22.6), and Testis (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC30A3 Gene

Protein tissue co-expression partners for SLC30A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC30A3 Gene:


SOURCE GeneReport for Unigene cluster for SLC30A3 Gene:

genes like me logo Genes that share expression patterns with SLC30A3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A3 Gene

Orthologs for SLC30A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC30A3 34 35
  • 99.4 (n)
(Canis familiaris)
Mammalia SLC30A3 34 35
  • 92.01 (n)
(Bos Taurus)
Mammalia SLC30A3 34 35
  • 89.43 (n)
(Mus musculus)
Mammalia Slc30a3 34 16 35
  • 86.43 (n)
(Rattus norvegicus)
Mammalia Slc30a3 34
  • 85.14 (n)
(Ornithorhynchus anatinus)
Mammalia SLC30A3 35
  • 82 (a)
(Anolis carolinensis)
Reptilia SLC30A3 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497671 34
  • 66.31 (n)
(Danio rerio)
Actinopterygii slc30a2 35
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31860 34 35
  • 51.02 (n)
BG:DS07295.1 36
  • 33 (a)
ZnT35C 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea T18D3.3 36
  • 41 (a)
cdf-2 35
  • 39 (a)
Y39E4A.2a 36
  • 38 (a)
Y39E4A.2b 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 35
  • 20 (a)
ZRC1 35
  • 20 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MTPA1 34
  • 47.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 25 (a)
Species where no ortholog for SLC30A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A3 Gene

Gene Tree for SLC30A3 (if available)
Gene Tree for SLC30A3 (if available)

Paralogs for SLC30A3 Gene

Paralogs for SLC30A3 Gene

(4) SIMAP similar genes for SLC30A3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with SLC30A3: view

Variants for SLC30A3 Gene

Sequence variations from dbSNP and Humsavar for SLC30A3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10176050 -- 27,257,068(+) GGAGG(A/G)GGAAG intron-variant
rs10182712 -- 27,273,339(+) gcaag(C/T)aggac intron-variant
rs10187781 -- 27,259,222(+) GGGAG(C/T)GGTGG intron-variant
rs10195289 -- 27,269,393(+) tagta(A/G)agacg intron-variant
rs10195290 -- 27,269,395(+) gtaga(A/G)acggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A3 Gene

Variant ID Type Subtype PubMed ID
nsv833603 CNV loss 17160897

Variation tolerance for SLC30A3 Gene

Residual Variation Intolerance Score: 92.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.97; 20.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A3 Gene

Disorders for SLC30A3 Gene

Relevant External Links for SLC30A3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC30A3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A3 Gene

Publications for SLC30A3 Gene

  1. ZnT-3, a putative transporter of zinc into synaptic vesicles. (PMID: 8962159) Palmiter R.D. … Findley S.D. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PMID: 17349999) FalcA^n-PAcrez J.M. … Dell'Angelica E.C. (Exp. Cell Res. 2007) 3 4 22 64
  3. SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity. (PMID: 19521526) Salazar G. … Faundez V. (PLoS ONE 2009) 3 22 64
  4. The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation. (PMID: 14657250) Salazar G. … Faundez V. (Mol. Biol. Cell 2004) 3 22 64
  5. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. (PMID: 14662799) Iguchi K. … Hirano K. (J. Androl. 2004) 3 22 64

Products for SLC30A3 Gene

Sources for SLC30A3 Gene

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