Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC30A2 Gene

protein-coding   GIFtS: 55
GCID: GC01M026365

Solute Carrier Family 30 (Zinc Transporter), Member 2


(Previous symbol: ZNT2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 21 2     PP124882
ZNT21 2 3 5     TNZD2
Solute Carrier Family 30 Member 22 3     Zinc Transporter 22
ZnT-22 3     

External Ids:    HGNC: 110131   Entrez Gene: 77802   Ensembl: ENSG000001580147   OMIM: 6096175   UniProtKB: Q9BRI33   

Export aliases for SLC30A2 gene to outside databases

Previous GC identifers: GC00U990435 GC01M025596 GC01M025970 GC01M025968 GC01M026048 GC01M026236 GC01M024618


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC30A2 Gene: 
SLC30A2 (solute carrier family 30 (zinc transporter), member 2) is a protein-coding gene. Diseases associated with SLC30A2 include acrodermatitis enteropathica, and acrodermatitis, and among its related super-pathways are Transmembrane transport of small molecules and Zinc transporters. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004610.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC30A2 gene promoter:
         USF1   NF-1/L   NF-1   GCNF   Lmo2   NF-E2 p45   GCNF-1   USF-1   NF-E2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A2 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC30A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

SLC30A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026365:  view genomic region     (about GC identifiers)

Start:
26,363,743 bp from pter      End:
26,372,624 bp from pter
Size:
8,882 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3 (See protein sequence)
Recommended Name: Zinc transporter 2  
Size: 323 amino acids; 35178 Da
Subunit: Homodimer
Subcellular location: Vacuole membrane; Multi-pass membrane protein
Subcellular location: Isoform 2: Lysosome membrane
Secondary accessions: Q71RC8
Alternative splicing: 2 isoforms:  Q9BRI3-1   Q9BRI3-2   

Explore the universe of human proteins at neXtProt for SLC30A2: NX_Q9BRI3

Explore proteomics data for SLC30A2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BRI3

  • SLC30A2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC30A2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001004434.1  NP_115902.1  

    ENSEMBL proteins: 
     ENSP00000363396   ENSP00000363394  
    Reactome Protein details: Q9BRI3
    Human Recombinant Protein Products for SLC30A2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for SLC30A2
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for SLC30A2
    GenScript Custom Purified and Recombinant Proteins Services for SLC30A2
    Novus Biologicals SLC30A2 Protein
    Novus Biologicals SLC30A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC30A2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17349999
    GO:0005765lysosomal membrane IDA17897319
    GO:0005770late endosome IDA17349999
    GO:0016021integral to membrane IEA--

    SLC30A2 for ontologies           About GeneDecksing



    SLC30A2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for SLC30A2
    GenScript Custom Superior Antibodies Services for SLC30A2
    Novus Biologicals SLC30A2 Antibody
    Abcam antibodies for SLC30A2
    Cloud-Clone Corp. Antibodies for SLC30A2 
    Search ThermoFisher Antibodies for SLC30A2
    Search LSBio for Antibodies for SLC30A2 

    Assay Products for SLC30A2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC30A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC30A2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for SLC30A2 
    Cloud-Clone Corp. CLIAs for SLC30A2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 2 
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q9BRI3

    ProtoNet protein and cluster: Q9BRI3

    UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    SLC30A2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--
         
    SLC30A2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC30A2:
     Increased Hepatitis C virus re  Synthetic lethal with gemcitab 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC30A2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC30A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC30A2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC30A2 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A2:
    hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC30A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC30A2
    Sirion Biotech Customized adenovirus for overexpression of SLC30A2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for SLC30A2 (see all 14)
    OriGene ORF clones in mouse, rat for SLC30A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC30A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC30A2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC30A2
    Search LifeMap BioReagents cell lines for SLC30A2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC30A2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Zinc transporters
    Zinc transporters0.68
    Zinc efflux and compartmentalization by the SLC30 family0.41
    Metal ion SLC transporters0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/6        Reactome Pathways for SLC30A2 (see all 6)
        Zinc efflux and compartmentalization by the SLC30 family
    SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Metal ion SLC transporters



    SLC30A2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC30A2

    1 Interacting protein for SLC30A2 (Q9BRI33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006829zinc ion transport IEA--
    GO:0055085transmembrane transport TAS--
    GO:0061090positive regulation of sequestering of zinc ion IDA17349999

    SLC30A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC30A2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC30A2 (ZNT2)

    1 Novoseek inferred chemical compound relationship for SLC30A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 59.8 42 19496757 (4), 17349999 (3), 19494234 (2), 11717422 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SLC30A2 / ZNT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC30A2 gene (2 alternative transcripts): 
    NM_001004434.1  NM_032513.3  

    Unigene Cluster for SLC30A2:

    Solute carrier family 30 (zinc transporter), member 2
    Hs.143545  [show with all ESTs]
    Unigene Representative Sequence: NM_001004434
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374278(uc001blh.1) ENST00000374276(uc001blg.1) ENST00000498060

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A2
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A2:
    hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC30A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC30A2 (see all 14)
    OriGene ORF clones in mouse, rat for SLC30A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2
    Sirion Biotech Customized lentivirus for stable overexpression of SLC30A2 
                         Customized lentivirus expression plasmids for stable overexpression of SLC30A2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC30A2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC30A2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2

    Additional mRNA sequence: 

    AF370409.1 AK023491.1 AK023504.1 AK094027.1 BC006251.2 

    6 DOTS entries:

    DT.97773888  DT.440047  DT.100776533  DT.100740629  DT.91955913  DT.100713441 

    24/62 AceView cDNA sequences (see all 62):

    CB216443 AI206058 BF109483 BU739871 AI795921 NM_032513 AI742143 CR592804 
    BF434534 BX345597 NM_001004434 BE326819 AI434813 BM720051 AI149014 BC006251 
    AW058510 BX108937 AW235651 AW195221 AX748418 AU135613 AI241120 CB126981 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -           -     -                                 
    SP2:              -                                                   
    SP3:                                                                  


    ECgene alternative splicing isoforms for SLC30A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC30A2 expression in normal human tissues (normalized intensities)      SLC30A2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGTTATC
    SLC30A2 Expression
    About this image


    SLC30A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Kidney (Urinary System)
     
     Placenta (Extraembryonic Tissues)

    See SLC30A2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC30A2

    SOURCE GeneReport for Unigene cluster: Hs.143545
        SABiosciences Custom PCR Arrays for SLC30A2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC30A2
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC30A2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC30A2 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a21 , 5 solute carrier family 30 (zinc transporter), member more1, 5 82.6(n)1
    80.87(a)1
      4 (66.61 cM)5
    2308101  NM_001039677.21  NP_001034766.11 
     1343431815 
    chicken
    (Gallus gallus)
    Aves SLC30A21 solute carrier family 30 (zinc transporter), member more 73.7(n)
    73.09(a)
      425575  XM_003642566.1  XP_003642614.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A26
    solute carrier family 30 (zinc transporter), membe...
    72(a)
    1 ↔ 1
    GL343480.1(275073-292818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117022 Xenopus laevis transcribed sequence with weak similarity more 76.23(n)    BJ626629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc30a21 solute carrier family 30 (zinc transporter), member more 65.84(n)
    65.02(a)
      563540  NM_001045020.1  NP_001038485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZnT35C1 CG3994-PA 57.37(n)
    53.41(a)
      34890  NM_135897.4  NP_609741.3 
    worm
    (Caenorhabditis elegans)
    Secernentea cdf-21 Protein CDF-2 53.02(n)
    50.31(a)
      188574  NM_077690.2  NP_510091.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMT2(YPL224C)4 Putative metal transporter involved in mitochondrial more   --   16(128088-126634) 855877  NP_015100.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MTPA21 metal tolerance protein A2 49.31(n)
    44.14(a)
      825050  NM_115743.3  NP_191440.2 


    ENSEMBL Gene Tree for SLC30A2 (if available)
    TreeFam Gene Tree for SLC30A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC30A2 gene
    SLC30A32  SLC30A82  SLC30A102  SLC30A42  SLC30A12  
    3 SIMAP similar genes for SLC30A2 using alignment to 1 protein entry:     ZNT2_HUMAN:
    SLC30A4    SLC30A8    SLC30A3

    SLC30A2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/220 SNPs in SLC30A2 are shown (see all 220)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693104
    Zinc deficiency, transient neonatal (TNZD)4--see VAR_0693102 G R mis40--------
    VAR_0693094
    Zinc deficiency, transient neonatal (TNZD)4--see VAR_0693092 H R mis40--------
    rs1861626261,2
    --26364086(+) AAGTTC/GCTGGG 2 -- ds50010--------
    rs1902110711,2
    --26364102(+) CCATGA/GCTTGG 2 -- ds50010--------
    rs112478491,2
    C,F,A,H--26364249(+) ACCCAT/CCTACC 2 -- ds500110Minor allele frequency- C:0.32NA WA CSA EA 372
    rs1482114211,2
    --26364287(+) GCTGGC/GAAGGC 2 -- ds50010--------
    rs115874751,2
    C,F,H--26364371(+) CACCTC/TGGGCC 2 -- ds5001 ese320Minor allele frequency- T:0.49NS EA NA WA 2340
    rs2022448731,2
    --26364483(+) ATGGT-/AAAAAG 2 -- ds50010--------
    rs1148691841,2
    C,F--26364530(+) TGGCTC/GTTGTT 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1454310161,2
    --26364642(+) ACCTTA/GTGACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC30A2 (26363743 - 26372624 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC30A2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871353CNV Loss21882294
    nsv834513CNV Gain17160897


    Human Gene Mutation Database (HGMD): SLC30A2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609617    OMIM disorders: --

    UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3
  • Zinc deficiency, transient neonatal (TNZD) [MIM:608118]: A disorder occurring in breast-fed infants as a
    consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc
    supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly
    in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6
    months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function.
    The disorder shows autosomal dominant inheritance with incomplete penetrance. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 7 diseases for SLC30A2:    About MalaCards
    acrodermatitis enteropathica    acrodermatitis    enteropathica    pneumonia
    prostate cancer    prostatitis    lung cancer


    SLC30A2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC30A2
    Human Genome Epidemiology (HuGE) Navigator: SLC30A2 (2 documents)

    Export disorders for SLC30A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC30A2 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC30A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency . (PubMed id 22733820)1, 2 Lasry I....Assaraf Y.G. (2012)
    2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (2009)
    3. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    4. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (2007)
    5. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (PubMed id 17065149)1, 2 Chowanadisai W....Kelleher S.L. (2006)
    6. Zinc transporter-2 (ZnT2) variants are localized to d istinct subcellular compartments and functionally transport zinc. (PubMed id 19496757)1, 9 Lopez V. and Kelleher S.L. (2009)
    7. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PubMed id 17349999)1, 9 Falcon-Perez J.M. and Dell'Angelica E.C. (2007)
    8. Polymorphisms of SLC30A2 and selected perinatal factor s associated with low milk zinc in Chinese breastfeeding women. (PubMed id 22364884)1 Qian L....Cai W. (2012)
    9. Gastrointestinal factors influencing zinc absorption and homeostasis. (PubMed id 21462106)1 Cousins R.J. (2010)
    10. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. (PubMed id 17971500)1 Overbeck S.... Rink L. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7780 HGNC: 11013 AceView: SLC30A2 Ensembl:ENSG00000158014 euGenes: HUgn7780
    ECgene: SLC30A2 H-InvDB: SLC30A2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC30A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC30A2 gene:
    Search GeneIP for patents involving SLC30A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for SLC30A2  
     OriGene qPCR primer pairs and template standards for SLC30A2   OriGene Protein Over-expression Lysate for SLC30A2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for SLC30A2  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC30A2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for SLC30A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC30A2   OriGene Custom Protein Services for SLC30A2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC30A2
     QIAGEN SeqTarget long-range PCR primers for resequencing SLC30A2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
     GenScript Custom Purified and Recombinant Proteins Services for SLC30A2 GenScript cDNA clones with any tag delivered in your preferred vector for SLC30A2
     GenScript Custom Assay Services for SLC30A2 GenScript Custom Superior Antibodies Services for SLC30A2
     GenScript Custom overexpressing Cell Line Services for SLC30A2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in SLC30A2 promoter
     Search Chromatin IP Primers for SLC30A2
     RT2 qPCR Primer Assay in human, mouse, rat SLC30A2
     Search GNC Networks for SLC30A2
     SABiosciences Custom PCR Arrays for SLC30A2
     Search Tocris compounds for SLC30A2 (ZNT2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     SLC30A2 antibodies
     SLC30A2 proteins
     SLC30A2 lysates
     Antibodies for SLC30A2
     See all of Abcam's Antibodies, Kits and Proteins for SLC30A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for SLC30A2
     Antibodies for SLC30A2
     ELISAs for SLC30A2
     CLIAs for SLC30A2
     Search LifeMap BioReagents cell lines for SLC30A2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2
     SwitchGear 3'UTR luciferase reporter plasmids for SLC30A2
     SwitchGear Promoter luciferase reporter plasmids for SLC30A2
     Search ThermoFisher Antibodies for SLC30A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC30A2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for SLC30A2
    Customized:
     lentivirus for stable overexpression of SLC30A2
     lentivirus expression plasmids for stable overexpression of SLC30A2
     adenovirus for overexpression of SLC30A2
     Search LSBio for Antibodies for SLC30A2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC30A2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4