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SLC30A2 Gene

protein-coding   GIFtS: 55
GCID: GC01M026365

Solute Carrier Family 30 (Zinc Transporter), Member 2


(Previous symbol: ZNT2)
  See SLC30A2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 21 2     TNZD2 5
ZNT21 2 3 5     PP124882
Solute Carrier Family 30 Member 22 3     Zinc Transporter 22
ZnT-22 3     

External Ids:    HGNC: 110131   Entrez Gene: 77802   Ensembl: ENSG000001580147   OMIM: 6096175   UniProtKB: Q9BRI33   

Export aliases for SLC30A2 gene to outside databases

Previous GC identifers: GC00U990435 GC01M025596 GC01M025970 GC01M025968 GC01M026048 GC01M026236 GC01M024618


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC30A2 Gene:
SLC30A2 (solute carrier family 30 (zinc transporter), member 2) is a protein-coding gene. Diseases associated with SLC30A2 include zinc deficiency, transient neonatal. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A3.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A2 gene promoter:
         USF1   NF-1/L   NF-1   GCNF   Lmo2   NF-E2 p45   GCNF-1   USF-1   NF-E2   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A2 promoter sequence
   Search Chromatin IP Primers for SLC30A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p35.3

SLC30A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026365:  view genomic region     (about GC identifiers)

Start:
26,363,743 bp from pter      End:
26,372,624 bp from pter
Size:
8,882 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3 (See protein sequence)
Recommended Name: Zinc transporter 2  
Size: 323 amino acids; 35178 Da
Subunit: Homodimer
Secondary accessions: Q71RC8
Alternative splicing: 2 isoforms:  Q9BRI3-1   Q9BRI3-2   

Explore the universe of human proteins at neXtProt for SLC30A2: NX_Q9BRI3

Explore proteomics data for SLC30A2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC30A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001004434.1  NP_115902.1  

    ENSEMBL proteins: 
     ENSP00000363396   ENSP00000363394  
    Reactome Protein details: Q9BRI3

    SLC30A2 Human Recombinant Protein Products:

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    Novus Biologicals SLC30A2 Protein
    Novus Biologicals SLC30A2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for SLC30A2

     
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    Search ThermoFisher Antibodies for SLC30A2
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 2
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q9BRI3

    ProtoNet protein and cluster: Q9BRI3

    UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    Find genes that share domains with SLC30A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC30A2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for SLC30A2:
     Increased Hepatitis C virus re  Synthetic lethal with gemcitab 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC30A2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC30A2
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    miRNA
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    miRTarBase miRNAs that target SLC30A2:
    hsa-mir-335-5p (MIRT017045)

    Block miRNA regulation of human, mouse, rat SLC30A2 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate SLC30A2:
    hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC30A2

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    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNT2_HUMAN, Q9BRI3: Vacuole membrane; Multi-pass membrane protein
    ZNT2_HUMAN, Q9BRI3: Isoform 2: Lysosome membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    lysosome5
    vacuole5
    endosome4
    plasma membrane3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA17349999
    GO:0005765lysosomal membrane IDA17897319
    GO:0005770late endosome IDA17349999
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC30A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC30A2 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc transporters0.00
    Zinc efflux and compartmentalization by the SLC30 family0.00


    Find genes that share SuperPaths with SLC30A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC30A2
        Zinc efflux and compartmentalization by the SLC30 family


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC30A2
    Interactions:

        Search GeneGlobe Interaction Network for SLC30A2

    1 Interacting protein for SLC30A2 (Q9BRI33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CREB3O438893I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006812cation transport ----
    GO:0006829zinc ion transport IEA--
    GO:0055085transmembrane transport TAS--
    GO:0061090positive regulation of sequestering of zinc ion IDA17349999

    Find genes that share ontologies with SLC30A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC30A2 (ZNT2)

    1 Novoseek inferred chemical compound relationship for SLC30A2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 59.8 42 19496757 (4), 17349999 (3), 19494234 (2), 11717422 (1) (see all 5)



    Find genes that share compounds with SLC30A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC30A2 gene (2 alternative transcripts): 
    NM_001004434.1  NM_032513.3  

    Unigene Cluster for SLC30A2:

    Solute carrier family 30 (zinc transporter), member 2
    Hs.143545  [show with all ESTs]
    Unigene Representative Sequence: NM_001004434
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374278(uc001blh.1) ENST00000374276(uc001blg.1) ENST00000498060

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate SLC30A2:
    hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for SLC30A2
    Predesigned siRNA for gene silencing in human, mouse, rat SLC30A2
    Clone
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    OriGene clones in human, mouse for SLC30A2 (see all 13)
    OriGene ORF clones in mouse, rat for SLC30A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC30A2
      QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
      QuantiFast Probe-based Assays in human, mouse, rat SLC30A2

    Additional mRNA sequence: 

    AF370409.1 AK023491.1 AK023504.1 AK094027.1 BC006251.2 

    6 DOTS entries:

    DT.97773888  DT.440047  DT.100776533  DT.100740629  DT.91955913  DT.100713441 

    Selected AceView cDNA sequences (see all 62):

    AI206058 BM720051 CR592804 AI795921 BC006251 BF434534 AI742143 NM_032513 
    CB216443 BU739871 BF109483 BX345597 BE326819 AI434813 AI149014 NM_001004434 
    AI241120 BF509598 AW235651 CB126981 AI759993 BX356481 AF370409 BX339627 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A2    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:              -           -     -                                 
    SP2:              -                                                   
    SP3:                                                                  


    ECgene alternative splicing isoforms for SLC30A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC30A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCAGTTATC
    SLC30A2 Expression
    About this image


    SLC30A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Kidney (Urinary System)
     
     Placenta (Extraembryonic Tissues)
    SLC30A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC30A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.143545
        Custom PCR Arrays for SLC30A2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC30A2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a21 , 5 solute carrier family 30 (zinc transporter), member more1, 5 82.6(n)1
    80.87(a)1
      4 (66.61 cM)5
    2308101  NM_001039677.21  NP_001034766.11 
     1343431815 
    chicken
    (Gallus gallus)
    Aves SLC30A21 solute carrier family 30 (zinc transporter), member more 72.14(n)
    70.75(a)
      425575  XM_003642566.2  XP_003642614.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A26
    solute carrier family 30 (zinc transporter), membe...
    72(a)
    1 ↔ 1
    GL343480.1(275073-292818)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.117022 Xenopus laevis transcribed sequence with weak similarity more 76.23(n)    BJ626629.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc30a21 solute carrier family 30 (zinc transporter), member more 65.94(n)
    65.02(a)
      563540  NM_001045020.1  NP_001038485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZnT35C1 ZnT35C 57.18(n)
    52.79(a)
      34890  NM_135897.5  NP_609741.3 
    worm
    (Caenorhabditis elegans)
    Secernentea cdf-21 cdf-2 53.33(n)
    50.62(a)
      188574  NM_077690.3  NP_510091.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMT2(YPL224C)4 Putative metal transporter involved in mitochondrial more   --   16(128088-126634) 855877  NP_015100.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ZAT1 ZAT 54.37(n)
    45.52(a)
      819293  NM_180128.2  NP_850459.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01284001 Os05g0128400 53.38(n)
    44.85(a)
      4337694  NM_001061074.1  NP_001054539.1 


    ENSEMBL Gene Tree for SLC30A2 (if available)
    TreeFam Gene Tree for SLC30A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC30A2 gene
    SLC30A32  SLC30A82  SLC30A102  SLC30A12  SLC30A42  
    3 SIMAP similar genes for SLC30A2 using alignment to 1 protein entry:     ZNT2_HUMAN:
    SLC30A4    SLC30A8    SLC30A3

    Find genes that share paralogs with SLC30A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC30A2 (see all 220)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0693104
    Zinc deficiency, transient neonatal (TNZD)4--see VAR_0693102 G R mis40--------
    VAR_0693094
    Zinc deficiency, transient neonatal (TNZD)4--see VAR_0693092 H R mis40--------
    rs1861626261,2
    --26364086(+) AAGTTC/GCTGGG 2 -- ds50010--------
    rs1902110711,2
    --26364102(+) CCATGA/GCTTGG 2 -- ds50010--------
    rs112478491,2
    C,F,A,H--26364249(+) ACCCAT/CCTACC 2 -- ds500110Minor allele frequency- C:0.32NA WA CSA EA 372
    rs1482114211,2
    --26364287(+) GCTGGC/GAAGGC 2 -- ds50010--------
    rs115874751,2
    C,F,H--26364371(+) CACCTC/TGGGCC 2 -- ds5001 ese320Minor allele frequency- T:0.49NS EA NA WA 2340
    rs2022448731,2
    --26364483(+) ATGGT-/AAAAAG 2 -- ds50010--------
    rs1148691841,2
    C,F--26364530(+) TGGCTC/GTTGTT 2 -- ut311Minor allele frequency- G:0.03WA 118
    rs1454310161,2
    --26364642(+) ACCTTA/GTGACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC30A2 (26363743 - 26372624 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for SLC30A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871353CNV Loss21882294
    nsv834513CNV Gain17160897

    Human Gene Mutation Database (HGMD): SLC30A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609617   
    OMIM disorders: 608118  
    UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3
  • Zinc deficiency, transient neonatal (TNZD) [MIM:608118]: A disorder occurring in breast-fed infants as a
    consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc
    supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly
    in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6
    months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function.
    The disorder shows autosomal dominant inheritance with incomplete penetrance. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 1 disease for SLC30A2:    
    About MalaCards
    zinc deficiency, transient neonatal


    Find genes that share disorders with SLC30A2           About GenesLikeMe

    Genetic Association Database (GAD): SLC30A2
    Human Genome Epidemiology (HuGE) Navigator: SLC30A2 (2 documents)

    Export disorders for SLC30A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC30A2 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with SLC30A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. (PubMed id 22733820)1, 2 Lasry I.... Assaraf Y.G. (J. Biol. Chem. 2012)
    2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    4. Integral and associated lysosomal membrane proteins. (PubMed id 17897319)1, 2 Schroeder B.... Hasilik A. (Traffic 2007)
    5. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (PubMed id 17065149)1, 2 Chowanadisai W.... Kelleher S.L. (J. Biol. Chem. 2006)
    6. Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc. (PubMed id 19496757)1, 9 Lopez V. and Kelleher S.L. (Biochem. J. 2009)
    7. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PubMed id 17349999)1, 9 FalcA^n-PAcrez J.M. and Dell'Angelica E.C. (Exp. Cell Res. 2007)
    8. Polymorphisms of SLC30A2 and selected perinatal factors associated with low milk zinc in Chinese breastfeeding women. (PubMed id 22364884)1 Qian L....Cai W. (Early Hum. Dev. 2012)
    9. Gastrointestinal factors influencing zinc absorption and homeostasis. (PubMed id 21462106)1 Cousins R.J. (Int J Vitam Nutr Res 2010)
    10. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. (PubMed id 17971500)1 Overbeck S.... Rink L. (J. Leukoc. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7780 HGNC: 11013 AceView: SLC30A2 Ensembl:ENSG00000158014 euGenes: HUgn7780
    ECgene: SLC30A2 H-InvDB: SLC30A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC30A2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC30A2 gene:
    Search GeneIP for patents involving SLC30A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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