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Aliases for SLC30A2 Gene

Aliases for SLC30A2 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 2 2 3
  • ZNT2 3 4 6
  • Solute Carrier Family 30 Member 2 3 4
  • ZnT-2 3 4
  • TNZD 3 6
  • Zinc Transporter 2 3
  • PP12488 3

External Ids for SLC30A2 Gene

Previous Symbols for SLC30A2 Gene

  • ZNT2

Summaries for SLC30A2 Gene

GeneCards Summary for SLC30A2 Gene

SLC30A2 (Solute Carrier Family 30 (Zinc Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC30A2 include zinc deficiency, transient neonatal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A2 Gene

Genomics for SLC30A2 Gene

Genomic Location for SLC30A2 Gene

Start:
26,037,252 bp from pter
End:
26,046,133 bp from pter
Size:
8,882 bases
Orientation:
Minus strand

Genomic View for SLC30A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A2 Gene

Regulatory Elements for SLC30A2 Gene

Proteins for SLC30A2 Gene

  • Protein details for SLC30A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRI3-ZNT2_HUMAN
    Recommended name:
    Zinc transporter 2
    Protein Accession:
    Q9BRI3
    Secondary Accessions:
    • Q71RC8

    Protein attributes for SLC30A2 Gene

    Size:
    323 amino acids
    Molecular mass:
    35178 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for SLC30A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A2 Gene

Proteomics data for SLC30A2 Gene at MOPED

Post-translational modifications for SLC30A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A2 Gene

Domains for SLC30A2 Gene

Gene Families for SLC30A2 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ZNT2_HUMAN
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.:
    • Q9BRI3
genes like me logo Genes that share domains with SLC30A2: view

Function for SLC30A2 Gene

Gene Ontology (GO) - Molecular Function for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Phenotypes for SLC30A2 Gene

genes like me logo Genes that share phenotypes with SLC30A2: view

miRNA for SLC30A2 Gene

miRTarBase miRNAs that target SLC30A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A2 Gene

Localization for SLC30A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A2 Gene

Vacuole membrane; Multi-pass membrane protein.
Isoform 2: Lysosome membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A2 Gene COMPARTMENTS Subcellular localization image for SLC30A2 gene
Compartment Confidence
lysosome 5
vacuole 5
endosome 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005765 lysosomal membrane IDA 17897319
GO:0005770 late endosome IDA 17349999
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Pathways for SLC30A2 Gene

genes like me logo Genes that share pathways with SLC30A2: view

Gene Ontology (GO) - Biological Process for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006829 zinc II ion transport IEA --
GO:0055085 transmembrane transport TAS --
GO:0061090 positive regulation of sequestering of zinc ion IDA 17349999
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Compounds for SLC30A2 Gene

(1) Novoseek inferred chemical compound relationships for SLC30A2 Gene

Compound -log(P) Hits PubMed IDs
zinc 59.8 11
genes like me logo Genes that share compounds with SLC30A2: view

Transcripts for SLC30A2 Gene

Unigene Clusters for SLC30A2 Gene

Solute carrier family 30 (zinc transporter), member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -
SP3:

Relevant External Links for SLC30A2 Gene

GeneLoc Exon Structure for
SLC30A2
ECgene alternative splicing isoforms for
SLC30A2

Expression for SLC30A2 Gene

mRNA expression in normal human tissues for SLC30A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A2 Gene

This gene is overexpressed in Pancreas (33.9) and Kidney - Cortex (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC30A2 Gene

SOURCE GeneReport for Unigene cluster for SLC30A2 Gene Hs.143545

genes like me logo Genes that share expressions with SLC30A2: view

Orthologs for SLC30A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A2 36
  • 99.46 (n)
  • 99.73 (a)
SLC30A2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A2 36
  • 85.5 (n)
  • 81.35 (a)
SLC30A2 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A2 36
  • 87.51 (n)
  • 88.14 (a)
SLC30A2 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a2 36
  • 82.6 (n)
  • 80.87 (a)
Slc30a2 16
Slc30a2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A2 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A2 37
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a2 36
  • 81.7 (n)
  • 79.89 (a)
chicken
(Gallus gallus)
Aves SLC30A2 36
  • 72.14 (n)
  • 70.75 (a)
SLC30A2 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A2 37
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11702 36
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a2 36
  • 68.04 (n)
  • 74.18 (a)
Str.8408 36
zebrafish
(Danio rerio)
Actinopterygii CR381630.1 37
  • 13 (a)
ManyToMany
slc30a2 36
  • 65.94 (n)
  • 65.02 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009005 36
  • 56.81 (n)
  • 52.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31860 37
  • 24 (a)
ManyToMany
ZnT35C 36
  • 57.18 (n)
  • 52.79 (a)
ZnT35C 37
  • 38 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cdf-2 36
  • 53.33 (n)
  • 50.62 (a)
cdf-2 37
  • 44 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 37
  • 18 (a)
ManyToMany
MMT2 39
ZRC1 37
  • 19 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons ZAT 36
  • 54.37 (n)
  • 45.52 (a)
rice
(Oryza sativa)
Liliopsida Os05g0128400 36
  • 53.38 (n)
  • 44.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 28 (a)
OneToMany
Species with no ortholog for SLC30A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A2 Gene

ENSEMBL:
Gene Tree for SLC30A2 (if available)
TreeFam:
Gene Tree for SLC30A2 (if available)

Paralogs for SLC30A2 Gene

Paralogs for SLC30A2 Gene

Selected SIMAP similar genes for SLC30A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC30A2: view

Variants for SLC30A2 Gene

Sequence variations from dbSNP and Humsavar for SLC30A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1316852 -- 26,041,770(+) AAGAC(A/G)AAGGT reference, synonymous-codon
rs2186234 -- 26,042,063(-) AGATG(C/G)CTTTT intron-variant
rs2369433 -- 26,047,935(-) TATTT(A/G)TTTCT upstream-variant-2KB
rs2997450 -- 26,046,783(-) GTTCT(C/T)TGTGC upstream-variant-2KB
rs2997451 -- 26,042,806(-) GGTTT(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A2 Gene

Variant ID Type Subtype PubMed ID
nsv834513 CNV Gain 17160897
nsv871353 CNV Loss 21882294

Relevant External Links for SLC30A2 Gene

HapMap Linkage Disequilibrium report
SLC30A2
Human Gene Mutation Database (HGMD)
SLC30A2

Disorders for SLC30A2 Gene

(1) OMIM Diseases for SLC30A2 Gene (609617)

UniProtKB/Swiss-Prot

ZNT2_HUMAN
  • Zinc deficiency, transient neonatal (TNZD) [MIM:608118]: A disorder occurring in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance. {ECO:0000269 PubMed:17065149, ECO:0000269 PubMed:22733820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC30A2

Genetic Association Database (GAD)
SLC30A2
Human Genome Epidemiology (HuGE) Navigator
SLC30A2
genes like me logo Genes that share disorders with SLC30A2: view

Publications for SLC30A2 Gene

  1. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PMID: 17349999) FalcA^n-PAcrez J.M. … Dell'Angelica E.C. (Exp. Cell Res. 2007) 3 23
  2. Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zinc. (PMID: 19496757) Lopez V. … Kelleher S.L. (Biochem. J. 2009) 3 23
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 49
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 49
  5. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. (PMID: 22733820) Lasry I. … Assaraf Y.G. (J. Biol. Chem. 2012) 3 4

Products for SLC30A2 Gene

Sources for SLC30A2 Gene

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