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Aliases for SLC30A2 Gene

Aliases for SLC30A2 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 2 2 3
  • ZNT2 3 4 6
  • Solute Carrier Family 30 Member 2 3 4
  • ZnT-2 3 4
  • TNZD 3 6
  • Zinc Transporter 2 3
  • PP12488 3

External Ids for SLC30A2 Gene

Previous HGNC Symbols for SLC30A2 Gene

  • ZNT2

Previous GeneCards Identifiers for SLC30A2 Gene

  • GC00U990435
  • GC01M025596
  • GC01M025970
  • GC01M025968
  • GC01M026236
  • GC01M026365
  • GC01M024618

Summaries for SLC30A2 Gene

GeneCards Summary for SLC30A2 Gene

SLC30A2 (Solute Carrier Family 30 (Zinc Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC30A2 include zinc deficiency, transient neonatal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A2 Gene

Genomics for SLC30A2 Gene

Regulatory Elements for SLC30A2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A2 Gene

26,037,252 bp from pter
26,046,133 bp from pter
8,882 bases
Minus strand

Genomic View for SLC30A2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A2 Gene

Proteins for SLC30A2 Gene

  • Protein details for SLC30A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter 2
    Protein Accession:
    Secondary Accessions:
    • Q71RC8

    Protein attributes for SLC30A2 Gene

    323 amino acids
    Molecular mass:
    35178 Da
    Quaternary structure:
    • Homodimer.

    Alternative splice isoforms for SLC30A2 Gene


neXtProt entry for SLC30A2 Gene

Proteomics data for SLC30A2 Gene at MOPED

Post-translational modifications for SLC30A2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC30A2 Gene

Domains for SLC30A2 Gene

Gene Families for SLC30A2 Gene

  • SLC :Solute carriers

Protein Domains for SLC30A2 Gene


Suggested Antigen Peptide Sequences for SLC30A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BRI3
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A2: view

Function for SLC30A2 Gene

Gene Ontology (GO) - Molecular Function for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008324 cation transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Phenotypes for SLC30A2 Gene

genes like me logo Genes that share phenotypes with SLC30A2: view

Animal Model Products

CRISPR Products

miRNA for SLC30A2 Gene

miRTarBase miRNAs that target SLC30A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A2 Gene

Localization for SLC30A2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A2 Gene

Vacuole membrane; Multi-pass membrane protein.
Isoform 2: Lysosome membrane.

Subcellular locations from

Jensen Localization Image for SLC30A2 Gene COMPARTMENTS Subcellular localization image for SLC30A2 gene
Compartment Confidence
lysosome 5
vacuole 5
endosome 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17349999
GO:0005765 lysosomal membrane IDA 17897319
GO:0005770 late endosome IDA 17349999
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Pathways for SLC30A2 Gene

genes like me logo Genes that share pathways with SLC30A2: view

Gene Ontology (GO) - Biological Process for SLC30A2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006812 cation transport --
GO:0006829 zinc II ion transport IEA --
GO:0055085 transmembrane transport TAS --
GO:0061090 positive regulation of sequestering of zinc ion IDA 17349999
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC30A2: view

Compounds for SLC30A2 Gene

(1) Novoseek inferred chemical compound relationships for SLC30A2 Gene

Compound -log(P) Hits PubMed IDs
zinc 59.8 11
genes like me logo Genes that share compounds with SLC30A2: view

Transcripts for SLC30A2 Gene

mRNA/cDNA for SLC30A2 Gene

Unigene Clusters for SLC30A2 Gene

Solute carrier family 30 (zinc transporter), member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: -

Relevant External Links for SLC30A2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC30A2 Gene

mRNA expression in normal human tissues for SLC30A2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A2 Gene

This gene is overexpressed in Pancreas (33.9) and Kidney - Cortex (8.7).

Protein differential expression in normal tissues for SLC30A2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC30A2 Gene

SOURCE GeneReport for Unigene cluster for SLC30A2 Gene Hs.143545

genes like me logo Genes that share expressions with SLC30A2: view

Expression partners for SLC30A2 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A2 Gene

Orthologs for SLC30A2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC30A2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC30A2 35
  • 85.5 (n)
  • 81.35 (a)
SLC30A2 36
  • 81 (a)
(Canis familiaris)
Mammalia SLC30A2 35
  • 87.51 (n)
  • 88.14 (a)
SLC30A2 36
  • 88 (a)
(Mus musculus)
Mammalia Slc30a2 35
  • 82.6 (n)
  • 80.87 (a)
Slc30a2 16
Slc30a2 36
  • 79 (a)
(Pan troglodytes)
Mammalia SLC30A2 35
  • 99.46 (n)
  • 99.73 (a)
SLC30A2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Slc30a2 35
  • 81.7 (n)
  • 79.89 (a)
(Monodelphis domestica)
Mammalia SLC30A2 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia SLC30A2 36
  • 74 (a)
(Gallus gallus)
Aves SLC30A2 35
  • 72.14 (n)
  • 70.75 (a)
SLC30A2 36
  • 64 (a)
(Anolis carolinensis)
Reptilia SLC30A2 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a2 35
  • 68.04 (n)
  • 74.18 (a)
Str.8408 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11702 35
(Danio rerio)
Actinopterygii slc30a2 35
  • 65.94 (n)
  • 65.02 (a)
CR381630.1 36
  • 13 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009005 35
  • 56.81 (n)
  • 52.41 (a)
fruit fly
(Drosophila melanogaster)
Insecta ZnT35C 35
  • 57.18 (n)
  • 52.79 (a)
CG31860 36
  • 24 (a)
ZnT35C 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea cdf-2 35
  • 53.33 (n)
  • 50.62 (a)
cdf-2 36
  • 44 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 18 (a)
ZRC1 36
  • 19 (a)
MMT2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ZAT 35
  • 54.37 (n)
  • 45.52 (a)
(Oryza sativa)
Liliopsida Os05g0128400 35
  • 53.38 (n)
  • 44.85 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
Species with no ortholog for SLC30A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A2 Gene

Gene Tree for SLC30A2 (if available)
Gene Tree for SLC30A2 (if available)

Paralogs for SLC30A2 Gene

Paralogs for SLC30A2 Gene

Selected SIMAP similar genes for SLC30A2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SLC30A2: view

Variants for SLC30A2 Gene

Sequence variations from dbSNP and Humsavar for SLC30A2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1316852 -- 26,041,770(+) AAGAC(A/G)AAGGT reference, synonymous-codon
rs2186234 -- 26,042,063(-) AGATG(C/G)CTTTT intron-variant
rs2369433 -- 26,047,935(-) TATTT(A/G)TTTCT upstream-variant-2KB
rs2997450 -- 26,046,783(-) GTTCT(C/T)TGTGC upstream-variant-2KB
rs2997451 -- 26,042,806(-) GGTTT(A/G)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC30A2 Gene

Variant ID Type Subtype PubMed ID
nsv834513 CNV Gain 17160897
nsv871353 CNV Loss 21882294

Relevant External Links for SLC30A2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A2 Gene

Disorders for SLC30A2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC30A2 Gene in MalaCards »

(1) Diseases for SLC30A2 Gene including...

(1) OMIM Diseases for SLC30A2 Gene (609617)


  • Zinc deficiency, transient neonatal (TNZD) [MIM:608118]: A disorder occurring in breast-fed infants as a consequence of low milk zinc concentration in their nursing mothers, which cannot be corrected by maternal zinc supplementation. A large amount of zinc, an essential trace mineral, is required for normal growth particularly in infants, and breast milk normally contains adequate zinc to meet the requirement for infants up to 4 to 6 months of age. Zinc deficiency can lead to dermatitis, alopecia, decreased growth, and impaired immune function. The disorder shows autosomal dominant inheritance with incomplete penetrance. {ECO:0000269 PubMed:17065149, ECO:0000269 PubMed:22733820}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC30A2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with SLC30A2: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for SLC30A2 Gene

Publications for SLC30A2 Gene

  1. A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency. (PMID: 22733820) Lasry I. … Assaraf Y.G. (J. Biol. Chem. 2012) 3 4
  2. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 48
  3. Polymorphisms in mitochondrial genes and prostate cancer risk. (PMID: 19064571) Wang L. … Thibodeau S.N. (Cancer Epidemiol. Biomarkers Prev. 2008) 3 48
  4. Integral and associated lysosomal membrane proteins. (PMID: 17897319) Schroeder B. … Hasilik A. (Traffic 2007) 3 4
  5. Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (PMID: 17065149) Chowanadisai W. … Kelleher S.L. (J. Biol. Chem. 2006) 3 4

Products for SLC30A2 Gene

Sources for SLC30A2 Gene

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