Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

SLC30A2 Gene

protein-coding GIFtS: 52
GCID: GC01M026365

solute carrier family 30 (zinc transporter), member 2

(Previous symbol: ZNT2)

Explore 6 diseases affiliated with
SLC30A2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 2¹ ²		PP12488²
ZNT2¹ ² ³ ⁵		TNZD²
Solute Carrier Family 30 Member 2² ³		Zinc Transporter 2²
ZnT-2² ³

External Ids:	HGNC: 11013¹	Entrez Gene: 7780²	Ensembl: ENSG00000158014⁷	OMIM: 609617⁵	UniProtKB: Q9BRI3³

Export aliases for SLC30A2 gene to outside databases

Previous GC identifers: GC00U990435 GC01M025596 GC01M025970 GC01M025968 GC01M026048 GC01M026236 GC01M024618

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004610.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the SLC30A2 gene promoter:
USF1 NF-1/L NF-1 GCNF Lmo2 NF-E2 p45 GCNF-1 USF-1 NF-E2 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: SLC30A2 promoter sequence

Search SABiosciences Chromatin IP Primers for SLC30A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3 Ensembl cytogenetic band: 1p36.11 HGNC cytogenetic band: 1p35.3

SLC30A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M026365: view genomic region (about GC identifiers)

Start:	26,363,743 bp from pter	End:	26,372,624 bp from pter
Size:	8,882 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3 (See protein sequence)

Recommended Name: Zinc transporter 2

Size: 323 amino acids; 35178 Da

Subcellular location: Vacuole membrane; Multi-pass membrane protein

Subcellular location: Isoform 2: Lysosome membrane

Secondary accessions: Q71RC8

Alternative splicing: 2 isoforms: Q9BRI3-1 Q9BRI3-2

Explore the universe of human proteins at neXtProt for SLC30A2: NX_Q9BRI3

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9BRI3

SLC30A2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001004434.1 NP_115902.1

ENSEMBL proteins:

ENSP00000363396 ENSP00000363394

Reactome Protein details: Q9BRI3
Human Recombinant Protein Products for SLC30A2:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 3): SLC30A2 OriGene Custom Protein Services for SLC30A2
	GenScript Custom Purified and Recombinant Proteins Services for SLC30A2
	Novus Biologicals SLC30A2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC30A2

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	17349999
GO:0005765	lysosomal membrane	IEA	--
GO:0005770	late endosome	IDA	17349999
GO:0010008	endosome membrane	--	--
GO:0016021	integral to membrane	IEA	--

SLC30A2 for ontologies About GeneDecksing

SLC30A2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC30A2
	GenScript Custom Superior Antibodies Services for SLC30A2
	Novus Biologicals SLC30A2 Antibody
	Abcam antibodies for SLC30A2
	Uscn Antibodies for SLC30A2
	Search ThermoFisher Antibodies for SLC30A2

Assay Products for SLC30A2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC30A2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC30A2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

SLC30A2 for domains About GeneDecksing

1 InterPro domain/family:

IPR002524 Cation_efflux

Graphical View of Domain Structure for InterPro Entry Q9BRI3

ProtoNet protein and cluster: Q9BRI3

UniProtKB/Swiss-Prot: ZNT2_HUMAN, Q9BRI3

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005385	zinc ion transmembrane transporter activity	--	--
GO:0008324	cation transmembrane transporter activity	IEA	--

SLC30A2 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for SLC30A2:

Increased Hepatitis C virus re

Synthetic lethal with gemcitab

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC30A2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC30A2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A2:
		hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: SLC30A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC30A2 (see all 7) OriGene shRNA RFP: SLC30A2 OriGene siRNA: SLC30A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC30A2

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for SLC30A2
			Sirion Biotech Customized adenovirus for overexpression of SLC30A2 Sirion Biotech Customized adenovirus for potent knockdown of SLC30A2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC30A2
		Search LifeMap BioReagents cell lines for SLC30A2
		Sirion Biotech Customized stable knockdown cell line services for SLC30A2 Sirion Biotech Customized inducible knockdown cell line services for SLC30A2 Sirion Biotech Customized stable overexpressing cell line services for SLC30A2 Sirion Biotech Customized inducible overexpressing cell line services for SLC30A2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

SLC-mediated transmembrane transport

	SLC-mediated transmembrane transport	1.00			Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38
	Transmembrane transport of small molecules	0.50

Zinc transporters

	Zinc transporters	1.00			Zinc efflux and compartmentalization by the SLC30 family	0.41
	Metal ion SLC transporters	0.68

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for SLC30A2 (see all 6)

	Zinc efflux and compartmentalization by the SLC30 family
	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Metal ion SLC transporters

SLC30A2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for SLC30A2

1 Interacting protein for SLC30A2 (Q9BRI3³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CREB3	O43889³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006829	zinc ion transport	IEA	--
GO:0055085	transmembrane transport	TAS	--
GO:0061090	positive regulation of sequestering of zinc ion	IDA	17349999
GO:0071577	zinc ion transmembrane transport	--	--

SLC30A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

SLC30A2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for SLC30A2
1 Novoseek chemical compound relationship for SLC30A2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	59.8	42	19496757 (4), 17349999 (3), 19494234 (2), 11717422 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about SLC30A2 / ZNT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for SLC30A2 gene (2 alternative transcripts):

NM_001004434.1 NM_032513.3

Unigene Cluster for SLC30A2:

Solute carrier family 30 (zinc transporter), member 2

Hs.143545 [show with all ESTs]

Unigene Representative Sequence: NM_001004434

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374278(uc001blh.1) ENST00000374276(uc001blg.1) ENST00000486732

ENST00000498060

miRNA Products:		OriGene 3'-UTR Clone (see all 2): SLC30A2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC30A2
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC30A2:
		hsa-miR-124 hsa-miR-4254 hsa-miR-377 hsa-miR-331-3p hsa-miR-506 hsa-miR-3652 hsa-miR-764 hsa-miR-29b-1*

		SwitchGear 3'UTR luciferase reporter plasmid: SLC30A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC30A2 (see all 7) OriGene shRNA RFP: SLC30A2 OriGene siRNA: SLC30A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2
		Sirion Biotech Custom design and validation of potent shRNA sequences against SLC30A2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): SLC30A2 (NM_001004434)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC30A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC30A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC30A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2

Additional cDNA sequence:

AF370409.1 AK023491.1 AK023504.1 AK094027.1 BC006251.2

6 DOTS entries:

DT.97773888 DT.440047 DT.100776533 DT.100740629 DT.91955913 DT.100713441

24/62 AceView cDNA sequences (see all 62):

BF434534 BF109483 CB216443 AI206058 BX345597 BE326819 BM720051 NM_032513

CR592804 AI795921 AI149014 BC006251 BU739871 NM_001004434 AI434813 AI742143

AW195221 CB126981 AF370409 AW235651 BI762893 AU156244 BF509598 AI759993

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A2 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8
SP1:					-				-		-
SP2:					-
SP3:

ECgene alternative splicing isoforms for SLC30A2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

SLC30A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCAGTTATC

About this image

SLC30A2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See SLC30A2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for SLC30A2

SOURCE GeneReport for Unigene cluster: Hs.143545

SABiosciences Custom PCR Arrays for SLC30A2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC30A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat SLC30A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for SLC30A2 gene from 9/31 species (see all 31) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	SLC30A2¹	solute carrier family 30 (zinc transporter), member more	73.7(n) 73.09(a)		425575 XM_003642566.1 XP_003642614.1
lizard (Anolis carolinensis)	Reptilia	SLC30A2⁶	--	70(a)	1 ↔ 1	GL343480.1(275491-284174)
African clawed frog (Xenopus laevis)	Amphibia	Xl.11702²	Xenopus laevis transcribed sequence with weak similarity more	76.23(n)		BJ626629.1
zebrafish (Danio rerio)	Actinopterygii	slc30a2¹	solute carrier family 30 (zinc transporter), member more	65.84(n) 65.02(a)		563540 NM_001045020.1 NP_001038485.1
fruit fly (Drosophila melanogaster)	Insecta	ZnT35C¹	CG3994-PA	57.37(n) 53.41(a)		34890 NM_135897.4 NP_609741.3
worm (Caenorhabditis elegans)	Secernentea	cdf-2¹	Protein CDF-2	53.02(n) 50.31(a)		188574 NM_077690.2 NP_510091.2
thale cress (Arabidopsis thaliana)	eudicotyledons	MTPA2¹	metal tolerance protein A2	49.31(n) 44.14(a)		825050 NM_115743.3 NP_191440.2
rice (Oryza sativa)	Liliopsida	--	cation efflux family protein, putative, expressed	32(a)	1 → many	5(1675472-1679040)
E. coli (Escherichia coli)	Gamma proteobacteria	zitB⁶	zinc efflux system	30(a)	1 → many	Chromosome(783105-784046)

ENSEMBL Gene Tree for SLC30A2 (if available)
TreeFam Gene Tree for SLC30A2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for SLC30A2 gene

SLC30A3² SLC30A8² SLC30A10² SLC30A1² SLC30A4²

3 SIMAP similar genes for SLC30A2 using alignment to 1 protein entry: ZNT2_HUMAN:

SLC30A4 SLC30A8 SLC30A3

SLC30A2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs186162626^1,2		--	26364086(+)	`AAGTTC/GCTGGG`	2	--	ds500¹		0	--	--	--	--
rs190211071^1,2		--	26364102(+)	`CCATGA/GCTTGG`	2	--	ds500¹		0	--	--	--	--
rs11247849^1,2	C,F,A,H	--	26364249(+)	`ACCCAT/CCTACC`	2	--	ds500¹		10		NA WA CSA EA	372
rs148211421^1,2		--	26364287(+)	`GCTGGC/GAAGGC`	2	--	ds500¹		0	--	--	--	--
rs11587475^1,2	C,F,H	--	26364371(+)	`CACCTC/TGGGCC`	2	--	ds500¹ ese³		20		NS EA NA WA	2340
rs202244873^1,2		--	26364483(+)	`ATGGT-/AAAAAG`	2	--	ds500¹		0	--	--	--	--
rs114869184^1,2	F	--	26364530(+)	`TGGCTC/GTTGTT`	2	--	ut3¹		1		WA	118
rs145431016^1,2		--	26364642(+)	`ACCTTA/GTGACA`	2	--	ut3¹		0	--	--	--	--
rs138067536^1,2		--	26364679(+)	`TGTCTC/TGATGA`	2	--	ut3¹		0	--	--	--	--
rs41284323^1,2	C,F	--	26364690(+)	`GTCGGG/AGACAG`	2	--	ut3¹		1		NA	120

HapMap Linkage Disequilibrium report for SLC30A2 (26363743 - 26372624 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC30A2: --
Human Gene Mutation Database (HGMD): SLC30A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC30A2

DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

SLC30A2 for disorders           About GeneDecksing

OMIM gene information: 609617    OMIM disorders: --

6 diseases for SLC30A2:    About MalaCards

acrodermatitis enteropathica enteropathica acrodermatitis prostate cancer

prostatitis malaria

Human Genome Epidemiology (HuGE) Navigator: SLC30A2 (2 documents)

Export disorders for SLC30A2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for SLC30A2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with SLC30A2)

Utopia: connect your pdf to the dynamic
world of online information

Zinc transporter-2 (ZnT2) variants are localized to d istinct subcellular compartments and functionally transport zinc. (PubMed id 19496757)^{1, 9} Lopez V. and Kelleher S.L. (2009)
Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. (PubMed id 17349999)^{1, 9} Falcon-Perez J.M. and Dell'Angelica E.C. (2007)
A dominant negative heterozygous G87R mutation in the zinc transporter, ZnT-2 (SLC30A2), results in transient neonatal zinc deficiency . (PubMed id 22733820)¹ Lasry I....Assaraf Y.G. (2012)
Gastrointestinal factors influencing zinc absorption and homeostasis. (PubMed id 21462106)¹ Cousins R.J. (2010)
Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. (PubMed id 17971500)¹ Overbeck S.... Rink L. (2008)
Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)¹ Wang L....Thibodeau S.N. (2008)
Integral and associated lysosomal membrane proteins. (PubMed id 17897319)² Schroeder B.... Hasilik A. (2007)
Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency. (PubMed id 17065149)¹ Chowanadisai W....Kelleher S.L. (2006)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)² Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 7780	HGNC: 11013	AceView: SLC30A2	Ensembl:ENSG00000158014	euGenes: HUgn7780
ECgene: SLC30A2	H-InvDB: SLC30A2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for SLC30A2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC30A2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for SLC30A2 gene:
Search GeneIP for patents involving SLC30A2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for SLC30A2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC30A2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC30A2
	OriGene Protein Over-expression Lysate for SLC30A2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for SLC30A2		OriGene 3'-UTR Clone for SLC30A2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC30A2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLC30A2		OriGene Custom Protein Services for SLC30A2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat SLC30A2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC30A2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC30A2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC30A2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC30A2

	GenScript Custom Purified and Recombinant Proteins Services for SLC30A2		GenScript cDNA clones with any tag delivered in your preferred vector for SLC30A2
	GenScript Custom Assay Services for SLC30A2		GenScript Custom Superior Antibodies Services for SLC30A2
	GenScript Custom overexpressing Cell Line Services for SLC30A2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in SLC30A2 promoter
	Search Chromatin IP Primers for SLC30A2
	RT² qPCR Primer Assay in human, mouse, rat SLC30A2
	Search GNC Networks for SLC30A2
	SABiosciences Custom PCR Arrays for SLC30A2

Search Tocris compounds for SLC30A2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLC30A2 antibodies
	SLC30A2 lysates

	Antibodies for SLC30A2
	See all of Abcam's Antibodies, Kits and Proteins for SLC30A2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

SLC30A2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for SLC30A2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A2

	SwitchGear 3'UTR luciferase reporter plasmids for SLC30A2
	SwitchGear Promoter luciferase reporter plasmids for SLC30A2

Search ThermoFisher Antibodies for SLC30A2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC30A2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for SLC30A2

Sirion Biotech Customized:

	stable knockdown cell line services for SLC30A2
	inducible knockdown cell line services for SLC30A2
	design and validation of potent shRNA sequences against SLC30A2
	adenovirus for potent knockdown of SLC30A2
	adenovirus for overexpression of SLC30A2
	stable overexpressing cell line services for SLC30A2
	inducible overexpressing cell line services for SLC30A2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLC30A2 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

SLC30A2 Gene

solute carrier family 30 (zinc transporter), member 2

Aliases
for SLC30A2 gene

Summaries
for SLC30A2 gene

Genomic Views
for SLC30A2 gene

Proteins
for SLC30A2 gene

Protein Domains /
Families
for SLC30A2 gene

Function
for SLC30A2 gene

Pathways & Interactions
for SLC30A2 gene

Drugs & Compounds
for SLC30A2 gene

Transcripts
for SLC30A2 gene

Expression
for SLC30A2 gene

Orthologs
for SLC30A2 gene

Paralogs
for SLC30A2 gene

Genomic Variants
for SLC30A2 gene

Disorders / Diseases
for SLC30A2 gene

Publications
for SLC30A2 gene

External Searches for SLC30A2 gene

Genome Databases showing SLC30A2 gene

Other Databases showing SLC30A2 gene

Specialized Databases showing SLC30A2 gene

Intellectual Property
for SLC30A2 gene

Products
for SLC30A2 gene

View Random Gene

Advanced Search

Export list of displayed genes

SLC30A2 Gene

solute carrier family 30 (zinc transporter), member 2

Aliasesfor SLC30A2 gene

Summariesfor SLC30A2 gene

Genomic Viewsfor SLC30A2 gene

Proteinsfor SLC30A2 gene

Protein Domains /Familiesfor SLC30A2 gene

Functionfor SLC30A2 gene

Pathways & Interactionsfor SLC30A2 gene

Drugs & Compoundsfor SLC30A2 gene

Transcriptsfor SLC30A2 gene

Expression for SLC30A2 gene

Orthologsfor SLC30A2 gene

Paralogsfor SLC30A2 gene

Genomic Variantsfor SLC30A2 gene

Disorders / Diseasesfor SLC30A2 gene

Publicationsfor SLC30A2 gene

External Searches for SLC30A2 gene

Genome Databases showing SLC30A2 gene

Other Databases showing SLC30A2 gene

Specialized Databases showing SLC30A2 gene

Intellectual Propertyfor SLC30A2 gene

Productsfor SLC30A2 gene

View Random Gene

Aliases
for SLC30A2 gene

Summaries
for SLC30A2 gene

Genomic Views
for SLC30A2 gene

Proteins
for SLC30A2 gene

Protein Domains /
Families
for SLC30A2 gene

Function
for SLC30A2 gene

Pathways & Interactions
for SLC30A2 gene

Drugs & Compounds
for SLC30A2 gene

Transcripts
for SLC30A2 gene

Expression
for SLC30A2 gene

Orthologs
for SLC30A2 gene

Paralogs
for SLC30A2 gene

Genomic Variants
for SLC30A2 gene

Disorders / Diseases
for SLC30A2 gene

Publications
for SLC30A2 gene

Intellectual Property
for SLC30A2 gene

Products
for SLC30A2 gene