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Aliases for SLC30A10 Gene

Aliases for SLC30A10 Gene

  • Solute Carrier Family 30 Member 10 2 3 4 5
  • Solute Carrier Family 30, Member 10 2 3
  • Zinc Transporter 8 2 3
  • ZnT-10 3 4
  • ZNT10 3 4
  • ZNT8 3 4
  • HMDPC 3
  • ZRC1 3

External Ids for SLC30A10 Gene

Previous GeneCards Identifiers for SLC30A10 Gene

  • GC01M216475
  • GC01M218153
  • GC01M219858
  • GC01M190762

Summaries for SLC30A10 Gene

Entrez Gene Summary for SLC30A10 Gene

  • This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

GeneCards Summary for SLC30A10 Gene

SLC30A10 (Solute Carrier Family 30 Member 10) is a Protein Coding gene. Diseases associated with SLC30A10 include hypermanganesemia with dystonia, polycythemia, and cirrhosis and dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease. GO annotations related to this gene include cation transmembrane transporter activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A10 Gene

  • Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A10 Gene

Genomics for SLC30A10 Gene

Regulatory Elements for SLC30A10 Gene

Genomic Location for SLC30A10 Gene

Chromosome:
1
Start:
219,685,427 bp from pter
End:
219,959,315 bp from pter
Size:
273,889 bases
Orientation:
Minus strand

Genomic View for SLC30A10 Gene

Genes around SLC30A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A10 Gene

Proteins for SLC30A10 Gene

  • Protein details for SLC30A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6XR72-ZNT10_HUMAN
    Recommended name:
    Zinc transporter 10
    Protein Accession:
    Q6XR72
    Secondary Accessions:
    • Q49AL9
    • Q9NPW0

    Protein attributes for SLC30A10 Gene

    Size:
    485 amino acids
    Molecular mass:
    52684 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP44332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in position 427.; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC30A10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC30A10 Gene

Proteomics data for SLC30A10 Gene at MOPED

Post-translational modifications for SLC30A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC30A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A10 Gene

Domains & Families for SLC30A10 Gene

Gene Families for SLC30A10 Gene

Protein Domains for SLC30A10 Gene

Graphical View of Domain Structure for InterPro Entry

Q6XR72

UniProtKB/Swiss-Prot:

ZNT10_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A10: view

Function for SLC30A10 Gene

Molecular function for SLC30A10 Gene

UniProtKB/Swiss-Prot Function:
Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways.
UniProtKB/Swiss-Prot Induction:
Down-regulated by ZNF658 in response to zinc.
genes like me logo Genes that share phenotypes with SLC30A10: view

Human Phenotype Ontology for SLC30A10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC30A10

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC30A10 Gene

Localization for SLC30A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A10 Gene COMPARTMENTS Subcellular localization image for SLC30A10 gene
Compartment Confidence
plasma membrane 5
vacuole 2
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for SLC30A10 Gene

Pathways & Interactions for SLC30A10 Gene

SuperPathways for SLC30A10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SLC30A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006828 manganese ion transport IMP 22341972
GO:0010043 response to zinc ion IBA --
GO:0071577 zinc II ion transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC30A10: view

No data available for Pathways by source and SIGNOR curated interactions for SLC30A10 Gene

Drugs & Compounds for SLC30A10 Gene

(1) Drugs for SLC30A10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC30A10: view

Transcripts for SLC30A10 Gene

mRNA/cDNA for SLC30A10 Gene

Unigene Clusters for SLC30A10 Gene

Solute carrier family 30, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A10 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for SLC30A10 Gene

GeneLoc Exon Structure for
SLC30A10
ECgene alternative splicing isoforms for
SLC30A10

Expression for SLC30A10 Gene

mRNA expression in normal human tissues for SLC30A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A10 Gene

This gene is overexpressed in Liver (x17.9).

Protein differential expression in normal tissues from HIPED for SLC30A10 Gene

This gene is overexpressed in Fetal Liver (66.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC30A10 Gene



SOURCE GeneReport for Unigene cluster for SLC30A10 Gene Hs.284450

mRNA Expression by UniProt/SwissProt for SLC30A10 Gene

Q6XR72-ZNT10_HUMAN
Tissue specificity: Specifically expressed in fetal liver and fetal brain.
genes like me logo Genes that share expression patterns with SLC30A10: view

Protein tissue co-expression partners for SLC30A10 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC30A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A10 35
  • 99.45 (n)
  • 98.76 (a)
SLC30A10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC30A10 36
  • 84 (a)
OneToOne
SLC30A10 35
  • 86.46 (n)
  • 84.12 (a)
dog
(Canis familiaris)
Mammalia SLC30A10 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a10 16
Slc30a10 35
  • 82.84 (n)
  • 80.43 (a)
Slc30a10 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A10 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A10 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a10 35
  • 81.57 (n)
  • 79.03 (a)
chicken
(Gallus gallus)
Aves SLC30A10 36
  • 53 (a)
OneToOne
SLC30A10 35
  • 64.61 (n)
  • 60.49 (a)
lizard
(Anolis carolinensis)
Reptilia SLC30A10 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15729 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a10 35
  • 66.15 (n)
  • 63.92 (a)
zebrafish
(Danio rerio)
Actinopterygii slc30a10 36
  • 46 (a)
OneToOne
slc30a10 35
  • 62.71 (n)
  • 57.63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5130 36
  • 20 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cdf-1 36
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COT1 36
  • 29 (a)
ManyToMany
ZRC1 36
  • 31 (a)
ManyToMany
COT1 38
Species with no ortholog for SLC30A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A10 Gene

ENSEMBL:
Gene Tree for SLC30A10 (if available)
TreeFam:
Gene Tree for SLC30A10 (if available)

Paralogs for SLC30A10 Gene

Paralogs for SLC30A10 Gene

(2) SIMAP similar genes for SLC30A10 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC30A10 Gene

genes like me logo Genes that share paralogs with SLC30A10: view

Variants for SLC30A10 Gene

Sequence variations from dbSNP and Humsavar for SLC30A10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_072573 Hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC)
VAR_072575 -
VAR_072577 Hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC)
rs950455 -- 219,935,576(-) GAAAA(C/T)ATAGA intron-variant
rs1270483 -- 219,961,032(-) tatat(A/T)tatat upstream-variant-2KB

Variation tolerance for SLC30A10 Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A10 Gene

HapMap Linkage Disequilibrium report
SLC30A10
Human Gene Mutation Database (HGMD)
SLC30A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC30A10 Gene

Disorders for SLC30A10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC30A10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypermanganesemia with dystonia, polycythemia, and cirrhosis
  • hypermanganesemia with dystonia polycythemia and cirrhosis
dystonia/parkinsonism, hypermanganesemia, polycythemia, and chronic liver disease
polycythemia
  • erythrocythemia
dystonia
  • dystonic disease
acid-labile subunit, deficiency of
  • acid-labile subunit deficiency
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZNT10_HUMAN
  • Hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC) [MIM:613280]: A metabolic autosomal recessive disorder characterized by dystonia, parkinsonism, extrapyramidal signs, severe hypermanganesemia, polycythemia, and chronic hepatic disease, including steatosis and cirrhosis. {ECO:0000269 PubMed:22341971, ECO:0000269 PubMed:22341972}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC30A10

Genetic Association Database (GAD)
SLC30A10
Human Genome Epidemiology (HuGE) Navigator
SLC30A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A10
genes like me logo Genes that share disorders with SLC30A10: view

No data available for Genatlas for SLC30A10 Gene

Publications for SLC30A10 Gene

  1. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PMID: 15154973) Seve M. … Favier A. (BMC Genomics 2004) 2 3 4 23 67
  2. SLC30A10 is a cell surface-localized manganese efflux transporter, and parkinsonism-causing mutations block its intracellular trafficking and efflux activity. (PMID: 25319704) Leyva-Illades D. … Mukhopadhyay S. (J. Neurosci. 2014) 3
  3. Interleukin-6 enhances manganese accumulation in SH-SY5Y cells: implications of the up-regulation of ZIP14 and the down-regulation of ZnT10. (PMID: 24576911) Fujishiro H. … Himeno S. (Metallomics 2014) 3
  4. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. (PMID: 23754948) Randall J.C. … Heid I.M. (PLoS Genet. 2013) 3
  5. Altered expression of ZnT10 in Alzheimer's disease brain. (PMID: 23741496) Bosomworth H.J. … Valentine R.A. (PLoS ONE 2013) 3

Products for SLC30A10 Gene

Sources for SLC30A10 Gene

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