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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC30A10 Gene

protein-coding   GIFtS: 50
GCID: GC01M219858

solute carrier family 30, member 10

 Explore 4 diseases affiliated with
SLC30A10 via our new
 Human Malady Compendium 
Biological research products
for SLC30A10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 30, Member 101 2     DKFZp547M2361
ZNT81 2 3     HMDPC2
ZnT-101 2 3     Zinc Transporter 102
ZNT102 3 5     Zinc Transporter 82
ZRC11 2     Solute Carrier Family 30 Member 103

External Ids:    HGNC: 253551   Entrez Gene: 555322   Ensembl: ENSG000001966607   OMIM: 6111465   UniProtKB: Q6XR723   

Export aliases for SLC30A10 gene to outside databases

Previous GC identifers: GC01M216475 GC01M218153 GC01M190762


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC30A10:
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in
maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to
result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript
variants have been observed for this gene. (provided by RefSeq, Mar 2012)

UniProtKB/Swiss-Prot: ZNT10_HUMAN, Q6XR72
Function: May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC30A10 gene promoter:
         NRSF form 1   Pax-2   Pax-2a   NRSF form 2   HNF-1A   E2F   E2F-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC30A10 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC30A10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC30A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q41   Ensembl cytogenetic band:  1q41   HGNC cytogenetic band: 1q41

SLC30A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A10 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M219858:  view genomic region     (about GC identifiers)

Start:
219,858,769 bp from pter      End:
220,131,989 bp from pter
Size:
273,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ZNT10_HUMAN, Q6XR72 (See protein sequence)
Recommended Name: Zinc transporter 10  
Size: 485 amino acids; 52684 Da
Subcellular location: Cell membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAP44332.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown
origin in position 427;
Secondary accessions: Q49AL9 Q9NPW0
Alternative splicing: 3 isoforms:  Q6XR72-4   Q6XR72-2   Q6XR72-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for SLC30A10: NX_Q6XR72

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6XR72

  • SLC30A10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_061183.2  
    ENSEMBL proteins: 
     ENSP00000349018   ENSP00000355893   ENSP00000439489   ENSP00000440627  

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    Uscn Proteins for SLC30A10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--


    SLC30A10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC30A10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q6XR72

    ProtoNet protein and cluster: Q6XR72

    1 Blocks protein family: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT10_HUMAN, Q6XR72
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ZNT10_HUMAN, Q6XR72
    Function: May be involved in zinc transport out of the cell, being a zinc-efflux transporter (By similarity)

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008324cation transmembrane transporter activity IEA--


    SLC30A10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC30A10:
     Increased gamma-H2AX phosphory 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC30A10

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    5/28 Interacting proteins for SLC30A10 (Q6XR723 ENSP000003558934) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    AP2A1O957823I2D: score=1 
    ARFGEF1Q9Y6D63I2D: score=1 
    ATP6V0A1Q930503I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006829zinc ion transport IEA--


    SLC30A10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC30A10 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC30A10
    1 Novoseek chemical compound relationship for SLC30A10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 44.5 8 19590848 (2), 19808923 (2), 20061424 (2), 19442898 (2) (see all 13)

    Search CenterWatch for drugs/clinical trials and news about SLC30A10 / ZNT10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC30A10 gene (2 alternative transcripts): 
    NM_018713.2  NM_001004433.1  

    Unigene Cluster for SLC30A10:

    Solute carrier family 30, member 10
    Hs.284450  [show with all ESTs]
    Unigene Representative Sequence: NR_046437
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484239(uc001hlu.1) ENST00000356609(uc001hlw.3 uc001hlx.3)
    ENST00000484079(uc001hlv.3) ENST00000366926 ENST00000536446 ENST00000536992


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    Additional cDNA sequence: 

    AK090806.1 AL359609.1 AY212919.1 NR_046437.1 

    6 DOTS entries:

    DT.95113429  DT.206334  DT.102836507  DT.121419630  DT.95095277  DT.99931053 

    20 AceView cDNA sequences:

    NM_001004433 AV681628 AK097467 BC036078 BK004163 NM_018713 AL359609 AK090806 
    Z39515 Z43436 AX746624 CB999545 BG564297 R37098 AY212919 BI599462 
    BF692411 R12032 D80088 D51313 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c
    SP1:                          -                           
    SP2:              -           -                           
    SP3:                                                      


    ECgene alternative splicing isoforms for SLC30A10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC30A10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See SLC30A10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC30A10

    SOURCE GeneReport for Unigene cluster: Hs.284450

    UniProtKB/Swiss-Prot: ZNT10_HUMAN, Q6XR72
    Tissue specificity: Specifically expressed in fetal liver and fetal brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC30A10 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC30A101 solute carrier family 30, member 10 64.16(n)
    60.04(a)
      421349  XM_419410.3  XP_419410.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A106
    --
    56(a)
    1 ↔ 1
    1(243174239-243181493)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.157292 Xenopus laevis transcribed sequence with moderate similarity more 74.09(n)    BJ035500.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc30a101 solute carrier family 30 (zinc transporter), member more 63.09(n)
    57.06(a)
      555724  NM_001128234.1  NP_001121706.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cdf-16
    Cation diffusion facilitator family protein 1
    17(a)
    1 → many
    X(6499872-6504576)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COT1(YOR316C)4
    ZRC11
    Vacuolar transporter that mediates zinc transport into more4
    Zrc1p1
    43.5(n)1
    36.67(a)1
      15(907555-906236)4
    8552841  NP_013970.11  8544944 
     NP_014961.14 


    ENSEMBL Gene Tree for SLC30A10 (if available)
    TreeFam Gene Tree for SLC30A10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC30A10 gene
    SLC30A32  SLC30A22  SLC30A82  SLC30A12  SLC30A42  
    2 SIMAP similar genes for SLC30A10 using alignment to 3 protein entries:     ZNT10_HUMAN (see all proteins):
    SLC30A1    ZNT4

    SLC30A10 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC30A10
    PGOHUM00000244424


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/343 NCBI SNPs in SLC30A10 are shown (see all 343    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730979431,2
    C,F,--190762834(+) TTCAGA/GCAATC 2 -- int15Minor allele frequency- G:0.17WA NA EA 362
    rs118102141,2
    C,F,H,--190763043(+) TCAGCG/AACATG 2 -- nc-transcript-variantut31 ese35Minor allele frequency- A:0.00NS EA NA 424
    rs120924811,2
    H--190763493(+) CTATAG/ACTGCA 2 -- nc-transcript-variantut31 ese34Minor allele frequency- A:0.00NS EA 420
    rs22317361,2
    F,H,--190764048(-) ATGCTC/GTGTGT 2 -- nc-transcript-variantut315Minor allele frequency- G:0.01NS EA WA 532
    rs66654911,2
    C,F,H,--190765423(+) TCAGTG/CCTGAT 2 -- int17Minor allele frequency- C:0.02NS EA NA WA 540
    rs782863311,2
    C,F,--190766226(+) GACACA/GGTGAC 2 -- int11Minor allele frequency- G:0.02WA 118
    rs342908061,2
    C,F--190766570(+) AGGCGC/TGTGCT 2 -- int13Minor allele frequency- T:0.33NA 6
    rs1127255461,2
    --190766659(+) GACCTC/TAGGTG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs66941291,2
    C,--190766670(+) actcaC/Tccacc 2 -- int12Minor allele frequency- T:0.15WA 120
    rs66637951,2
    C,F,H,--190767312(+) TGGAGT/GTTTTT 2 -- int16Minor allele frequency- G:0.04NS EA NA WA 538

    HapMap Linkage Disequilibrium report for SLC30A10 (219858769 - 220108769 bp, first 250kb of SLC30A10)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for SLC30A10: --
    Human Gene Mutation Database (HGMD): SLC30A10

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC30A10
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC30A10 for disorders           About GeneDecksing

    OMIM gene information: 611146    OMIM disorders: --

    4 diseases for SLC30A10:    About MalaCards
    polycystic ovary syndrome    insulinoma    pneumonia    prostatitis

    1 disease from the University of Copenhagen DISEASES database for SLC30A10:
    Diabetes mellitus

    1 Novoseek disease relationship for SLC30A10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diabetes autoimmune 67.6 4 20061424 (2), 19808923 (1)

    Human Genome Epidemiology (HuGE) Navigator: SLC30A10 (1 document)

    Export disorders for SLC30A10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC30A10 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with SLC30A10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. (PubMed id 15154973)1, 2, 3, 9 Seve M.... Favier A. (2004)
    2. Efflux function, tissue-specific expression and intrac ellular trafficking of the Zn transporter ZnT10 indicate roles in adult Zn homeo stasis. (PubMed id 22706290)1 Bosomworth H.J....Valentine R.A. (2012)
    3. Mutations in SLC30A10 cause parkinsonism and dystonia with hypermanganesemia, polycythemia, and chronic liver disease. (PubMed id 22341971)1 Quadri M....Bonifati V. (2012)
    4. Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. (PubMed id 22341972)1 Tuschl K....Mills P.B. (2012)
    5. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1 Wang L....Thibodeau S.N. (2008)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55532 HGNC: 25355 AceView: SLC30A10 Ensembl:ENSG00000196660 euGenes: HUgn55532
    ECgene: SLC30A10 H-InvDB: SLC30A10

    (According to HUGE)
    About This Section
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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    About This Section
    NameDescription
    PharmGKB entry for SLC30A10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for SLC30A10 gene:
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