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Aliases for SLC30A1 Gene

Aliases for SLC30A1 Gene

  • Solute Carrier Family 30 (Zinc Transporter), Member 1 2 3
  • ZNT1 3 4 6
  • Solute Carrier Family 30 Member 1 3 4
  • ZnT-1 3 4
  • Zinc Transporter 1 3
  • ZRC1 3

External Ids for SLC30A1 Gene

Previous HGNC Symbols for SLC30A1 Gene

  • ZNT1

Previous GeneCards Identifiers for SLC30A1 Gene

  • GC01M210481
  • GC01M207611
  • GC01M208387
  • GC01M208828
  • GC01M208137
  • GC01M209811
  • GC01M211744
  • GC01M182425

Summaries for SLC30A1 Gene

GeneCards Summary for SLC30A1 Gene

SLC30A1 (Solute Carrier Family 30 (Zinc Transporter), Member 1) is a Protein Coding gene. Diseases associated with SLC30A1 include lung cancer. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Mineral absorption. GO annotations related to this gene include zinc ion transmembrane transporter activity and calcium channel inhibitor activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A1 Gene

  • May be involved in zinc transport out of the cell

Gene Wiki entry for SLC30A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A1 Gene

Genomics for SLC30A1 Gene

Regulatory Elements for SLC30A1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC30A1 Gene

Start:
211,571,568 bp from pter
End:
211,578,757 bp from pter
Size:
7,190 bases
Orientation:
Minus strand

Genomic View for SLC30A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC30A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A1 Gene

Proteins for SLC30A1 Gene

  • Protein details for SLC30A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M5-ZNT1_HUMAN
    Recommended name:
    Zinc transporter 1
    Protein Accession:
    Q9Y6M5
    Secondary Accessions:
    • Q0VAK9
    • Q9BZF6

    Protein attributes for SLC30A1 Gene

    Size:
    507 amino acids
    Molecular mass:
    55300 Da
    Quaternary structure:
    • Multimer.

neXtProt entry for SLC30A1 Gene

Proteomics data for SLC30A1 Gene at MOPED

Post-translational modifications for SLC30A1 Gene

  • Glycosylation at Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC30A1 Gene

Domains for SLC30A1 Gene

Gene Families for SLC30A1 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC30A1 Gene

Suggested Antigen Peptide Sequences for SLC30A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6M5

UniProtKB/Swiss-Prot:

ZNT1_HUMAN :
  • Q9Y6M5
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A1: view

Function for SLC30A1 Gene

Molecular function for SLC30A1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in zinc transport out of the cell

Gene Ontology (GO) - Molecular Function for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IEA --
GO:0005515 protein binding IPI 18158319
GO:0008324 cation transmembrane transporter activity --
GO:0019855 calcium channel inhibitor activity ISS --
genes like me logo Genes that share ontologies with SLC30A1: view

Phenotypes for SLC30A1 Gene

genes like me logo Genes that share phenotypes with SLC30A1: view

Animal Model Products

CRISPR Products

miRNA for SLC30A1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SLC30A1 Gene

Localization for SLC30A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC30A1 Gene COMPARTMENTS Subcellular localization image for SLC30A1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18158319
GO:0005783 endoplasmic reticulum IDA 18158319
GO:0005794 Golgi apparatus IDA 18158319
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC30A1: view

Pathways for SLC30A1 Gene

genes like me logo Genes that share pathways with SLC30A1: view

Interacting Proteins for SLC30A1 Gene

Gene Ontology (GO) - Biological Process for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006812 cation transport --
GO:0006829 zinc II ion transport ISS --
GO:0006874 cellular calcium ion homeostasis ISS --
GO:0006882 cellular zinc ion homeostasis ISS --
genes like me logo Genes that share ontologies with SLC30A1: view

Compounds for SLC30A1 Gene

(3) Novoseek inferred chemical compound relationships for SLC30A1 Gene

Compound -log(P) Hits PubMed IDs
zinc 77.7 55
cadmium 29.4 1
calcium 14.8 8
genes like me logo Genes that share compounds with SLC30A1: view

Transcripts for SLC30A1 Gene

mRNA/cDNA for SLC30A1 Gene

(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC30A1 Gene

Solute carrier family 30 (zinc transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC30A1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A1 Gene

No ASD Table

Relevant External Links for SLC30A1 Gene

GeneLoc Exon Structure for
SLC30A1
ECgene alternative splicing isoforms for
SLC30A1

Expression for SLC30A1 Gene

mRNA expression in normal human tissues for SLC30A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A1 Gene

This gene is overexpressed in Liver (6.0).

Protein differential expression in normal tissues for SLC30A1 Gene

This gene is overexpressed in Liver (15.7), Placenta (9.9), Adrenal (7.2), Fetal Liver (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A1 Gene

SOURCE GeneReport for Unigene cluster for SLC30A1 Gene Hs.519469

genes like me logo Genes that share expressions with SLC30A1: view

Expression partners for SLC30A1 Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A1 Gene

Orthologs for SLC30A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC30A1 35
  • 92.06 (n)
  • 88.69 (a)
SLC30A1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC30A1 35
  • 93.01 (n)
  • 88.91 (a)
SLC30A1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc30a1 35
  • 83 (n)
  • 85.46 (a)
Slc30a1 16
Slc30a1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC30A1 35
  • 99.33 (n)
  • 99.2 (a)
SLC30A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc30a1 35
  • 83.9 (n)
  • 86.08 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC30A1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A1 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A1 35
  • 68.42 (n)
  • 61.78 (a)
SLC30A1 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC30A1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a1 35
  • 64.1 (n)
  • 60.42 (a)
Str.18707 35
African clawed frog
(Xenopus laevis)
Amphibia slc30a1-prov 35
zebrafish
(Danio rerio)
Actinopterygii slc30a1a 35
  • 62.72 (n)
  • 62.72 (a)
zgc77589 35
slc30a1a 36
  • 61 (a)
OneToMany
slc30a1b 36
  • 54 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005918 35
  • 52.23 (n)
  • 45.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta ZnT63C 35
  • 52.79 (n)
  • 47.84 (a)
ZnT63C 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cdf-1 36
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR129C 35
  • 50.73 (n)
  • 42.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08723g 35
  • 47.28 (n)
  • 35.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZRC1 35
  • 48.35 (n)
  • 41.93 (a)
COT1 36
  • 30 (a)
ManyToMany
ZRC1 36
  • 33 (a)
ManyToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03145 35
  • 49.08 (n)
  • 36.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zhf1 35
  • 48 (n)
  • 37.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10885 36
  • 38 (a)
OneToOne
Species with no ortholog for SLC30A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A1 Gene

ENSEMBL:
Gene Tree for SLC30A1 (if available)
TreeFam:
Gene Tree for SLC30A1 (if available)

Paralogs for SLC30A1 Gene

Paralogs for SLC30A1 Gene

Selected SIMAP similar genes for SLC30A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A1: view

Variants for SLC30A1 Gene

Sequence variations from dbSNP and Humsavar for SLC30A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2278651 -- 211,577,718(-) GGTGA(C/T)CATCA intron-variant
rs2278652 -- 211,577,683(-) TTGGC(C/T)GTCTT intron-variant
rs2358242 -- 211,579,592(+) CAAAG(G/T)CTGCA upstream-variant-2KB
rs3041304 -- 211,579,541(+) CTGGC(-/TTCCGCG)CTGCG upstream-variant-2KB
rs3041307 -- 211,579,583(+) GCCGG(-/GCTGCAAAG)TCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC30A1 Gene

Variant ID Type Subtype PubMed ID
nsv832514 CNV Loss 17160897
nsv826542 CNV Gain 20364138
esv27192 CNV Loss 19812545

Relevant External Links for SLC30A1 Gene

HapMap Linkage Disequilibrium report
SLC30A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A1 Gene

Disorders for SLC30A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SLC30A1 Gene in MalaCards »

(1) Diseases for SLC30A1 Gene including...

(1) University of Copenhagen DISEASES for SLC30A1 Gene

(2) Novoseek inferred disease relationships for SLC30A1 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 25.6 1
ischemia 0 1

Relevant External Links for SLC30A1

Genetic Association Database (GAD)
SLC30A1
Human Genome Epidemiology (HuGE) Navigator
SLC30A1
genes like me logo Genes that share disorders with SLC30A1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for SLC30A1 Gene

Publications for SLC30A1 Gene

  1. Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells. (PMID: 14662799) Iguchi K. … Hirano K. (J. Androl. 2004) 3 23
  2. A role for ZnT-1 in regulating cellular cation influx. (PMID: 15451416) Segal D. … Sekler I. (Biochem. Biophys. Res. Commun. 2004) 3 23
  3. Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. (PMID: 16179263) Lovell M.A. … Markesbery W.R. (Neurotox Res 2005) 3 23
  4. Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. (PMID: 17786585) Zhang L.Y. … Kong F. (Mol. Biol. Rep. 2008) 3 23
  5. Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. (PMID: 17971132) Etzion Y. … Katz A. (J. Cardiovasc. Electrophysiol. 2008) 3 23

Products for SLC30A1 Gene

Sources for SLC30A1 Gene

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