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Aliases for SLC30A1 Gene

Aliases for SLC30A1 Gene

  • Solute Carrier Family 30 Member 1 2 3 4
  • Solute Carrier Family 30 (Zinc Transporter), Member 1 2 3 5
  • ZnT-1 3 4
  • ZNT1 3 4
  • ZRC1 3

External Ids for SLC30A1 Gene

Previous HGNC Symbols for SLC30A1 Gene

  • ZNT1

Previous GeneCards Identifiers for SLC30A1 Gene

  • GC01M210481
  • GC01M207611
  • GC01M208387
  • GC01M208828
  • GC01M208137
  • GC01M209811
  • GC01M211744
  • GC01M182425

Summaries for SLC30A1 Gene

GeneCards Summary for SLC30A1 Gene

SLC30A1 (Solute Carrier Family 30 Member 1) is a Protein Coding gene. Among its related pathways are Metal ion SLC transporters and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include cation transmembrane transporter activity and calcium channel inhibitor activity. An important paralog of this gene is SLC30A4.

UniProtKB/Swiss-Prot for SLC30A1 Gene

  • May be involved in zinc transport out of the cell.

Gene Wiki entry for SLC30A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A1 Gene

Genomics for SLC30A1 Gene

Regulatory Elements for SLC30A1 Gene

Enhancers for SLC30A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC30A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC30A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC30A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC30A1 Gene

211,571,568 bp from pter
211,578,757 bp from pter
7,190 bases
Minus strand

Genomic View for SLC30A1 Gene

Genes around SLC30A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A1 Gene

Proteins for SLC30A1 Gene

  • Protein details for SLC30A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter 1
    Protein Accession:
    Secondary Accessions:
    • Q0VAK9
    • Q9BZF6

    Protein attributes for SLC30A1 Gene

    507 amino acids
    Molecular mass:
    55300 Da
    Quaternary structure:
    • Multimer.

neXtProt entry for SLC30A1 Gene

Proteomics data for SLC30A1 Gene at MOPED

Post-translational modifications for SLC30A1 Gene

  • Glycosylation at Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for ZnT1

No data available for DME Specific Peptides for SLC30A1 Gene

Domains & Families for SLC30A1 Gene

Gene Families for SLC30A1 Gene

Protein Domains for SLC30A1 Gene

Suggested Antigen Peptide Sequences for SLC30A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A1: view

Function for SLC30A1 Gene

Molecular function for SLC30A1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in zinc transport out of the cell.
genes like me logo Genes that share phenotypes with SLC30A1: view

Animal Models for SLC30A1 Gene

MGI Knock Outs for SLC30A1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A1 Gene

Localization for SLC30A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC30A1 Gene COMPARTMENTS Subcellular localization image for SLC30A1 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
plasma membrane 5
vacuole 2
cytosol 1
endosome 1
extracellular 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18158319
genes like me logo Genes that share ontologies with SLC30A1: view

Pathways & Interactions for SLC30A1 Gene

genes like me logo Genes that share pathways with SLC30A1: view

Interacting Proteins for SLC30A1 Gene

Gene Ontology (GO) - Biological Process for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006829 zinc II ion transport IEA,ISS --
GO:0010043 response to zinc ion IBA --
GO:0055085 transmembrane transport IEA --
GO:0070574 cadmium ion transmembrane transport IEA,ISS --
genes like me logo Genes that share ontologies with SLC30A1: view

No data available for SIGNOR curated interactions for SLC30A1 Gene

Drugs & Compounds for SLC30A1 Gene

(2) Drugs for SLC30A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC30A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC30A1: view

Transcripts for SLC30A1 Gene

mRNA/cDNA for SLC30A1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC30A1 Gene

Solute carrier family 30 (zinc transporter), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A1 Gene

No ASD Table

Relevant External Links for SLC30A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC30A1 Gene

mRNA expression in normal human tissues for SLC30A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A1 Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for SLC30A1 Gene

This gene is overexpressed in Liver (15.7), Placenta (9.9), Adrenal (7.2), Fetal Liver (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC30A1 Gene

SOURCE GeneReport for Unigene cluster for SLC30A1 Gene Hs.519469

genes like me logo Genes that share expression patterns with SLC30A1: view

Protein tissue co-expression partners for SLC30A1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SLC30A1 Gene

Orthologs for SLC30A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC30A1 35
  • 92.06 (n)
  • 88.69 (a)
SLC30A1 36
  • 88 (a)
(Canis familiaris)
Mammalia SLC30A1 35
  • 93.01 (n)
  • 88.91 (a)
SLC30A1 36
  • 89 (a)
(Mus musculus)
Mammalia Slc30a1 35
  • 83 (n)
  • 85.46 (a)
Slc30a1 16
Slc30a1 36
  • 86 (a)
(Pan troglodytes)
Mammalia SLC30A1 35
  • 99.33 (n)
  • 99.2 (a)
SLC30A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Slc30a1 35
  • 83.9 (n)
  • 86.08 (a)
(Monodelphis domestica)
Mammalia SLC30A1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia SLC30A1 36
  • 83 (a)
(Gallus gallus)
Aves SLC30A1 35
  • 68.42 (n)
  • 61.78 (a)
SLC30A1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia SLC30A1 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a1 35
  • 64.1 (n)
  • 60.42 (a)
Str.18707 35
African clawed frog
(Xenopus laevis)
Amphibia slc30a1-prov 35
(Danio rerio)
Actinopterygii slc30a1a 35
  • 62.72 (n)
  • 62.72 (a)
zgc77589 35
slc30a1a 36
  • 61 (a)
slc30a1b 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005918 35
  • 52.23 (n)
  • 45.1 (a)
fruit fly
(Drosophila melanogaster)
Insecta ZnT63C 35
  • 52.79 (n)
  • 47.84 (a)
ZnT63C 36
  • 39 (a)
(Caenorhabditis elegans)
Secernentea cdf-1 36
  • 24 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR129C 35
  • 50.73 (n)
  • 42.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08723g 35
  • 47.28 (n)
  • 35.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZRC1 35
  • 48.35 (n)
  • 41.93 (a)
COT1 36
  • 30 (a)
ZRC1 36
  • 33 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03145 35
  • 49.08 (n)
  • 36.5 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zhf1 35
  • 48 (n)
  • 37.98 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10885 36
  • 38 (a)
Species with no ortholog for SLC30A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A1 Gene

Gene Tree for SLC30A1 (if available)
Gene Tree for SLC30A1 (if available)

Paralogs for SLC30A1 Gene

Paralogs for SLC30A1 Gene

(1) SIMAP similar genes for SLC30A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A1: view

Variants for SLC30A1 Gene

Sequence variations from dbSNP and Humsavar for SLC30A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2358242 -- 211,579,592(+) CAAAG(G/T)CTGCA upstream-variant-2KB
rs2278651 -- 211,577,718(-) GGTGA(C/T)CATCA intron-variant
rs2278652 -- 211,577,683(-) TTGGC(C/T)GTCTT intron-variant
rs3041304 -- 211,579,541(+) CTGGC(-/TTC/TTCCGCG)CTGCG upstream-variant-2KB
rs3041307 -- 211,579,583(+) GCCGG(-/GCTGCAAAG)TCTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC30A1 Gene

Variant ID Type Subtype PubMed ID
nsv832514 CNV Loss 17160897
nsv826542 CNV Gain 20364138
esv27192 CNV Loss 19812545

Variation tolerance for SLC30A1 Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SLC30A1 Gene

Disorders for SLC30A1 Gene

Relevant External Links for SLC30A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for SLC30A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A1 Gene

Publications for SLC30A1 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 48 67
  2. Regulation of metallothioneins and ZnT-1 transporter expression in human hepatoma cells HepG2 exposed to zinc and cadmium. (PMID: 19900532) Urani C. … Gribaldo L. (Toxicol In Vitro 2010) 3 23
  3. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. (PMID: 20201890) Beharier O. … Moran A. (Ann. N. Y. Acad. Sci. 2010) 3 23
  4. Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. (PMID: 19767393) Levy S. … Moran A. (J. Biol. Chem. 2009) 3 23
  5. Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts. (PMID: 17786585) Zhang L.Y. … Kong F. (Mol. Biol. Rep. 2008) 3 23

Products for SLC30A1 Gene

Sources for SLC30A1 Gene