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Aliases for SLC30A1 Gene

Aliases for SLC30A1 Gene

  • Solute Carrier Family 30 Member 1 2 3 4 5
  • Solute Carrier Family 30 (Zinc Transporter), Member 1 2 3
  • ZnT-1 3 4
  • ZNT1 3 4
  • Zinc Transporter 1 3
  • ZRC1 3

External Ids for SLC30A1 Gene

Previous HGNC Symbols for SLC30A1 Gene

  • ZNT1

Previous GeneCards Identifiers for SLC30A1 Gene

  • GC01M210481
  • GC01M207611
  • GC01M208387
  • GC01M208828
  • GC01M208137
  • GC01M209811
  • GC01M211744
  • GC01M182425

Summaries for SLC30A1 Gene

GeneCards Summary for SLC30A1 Gene

SLC30A1 (Solute Carrier Family 30 Member 1) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include cation transmembrane transporter activity and calcium channel inhibitor activity. An important paralog of this gene is SLC30A10.

UniProtKB/Swiss-Prot for SLC30A1 Gene

  • May be involved in zinc transport out of the cell.

Gene Wiki entry for SLC30A1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC30A1 Gene

Genomics for SLC30A1 Gene

Regulatory Elements for SLC30A1 Gene

Enhancers for SLC30A1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G211513 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.4 +62.8 62797 4.4 HNRNPUL1 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A1 TRAF5 LINC00467 RD3 GC01M211578
GH01G211641 1.5 Ensembl ENCODE dbSUPER 17 -64.7 -64714 4.3 ATF1 MLX ARID4B FEZF1 ZNF48 YY1 TCF12 ZNF121 SLC30A9 GLIS2 SLC30A1 ENSG00000223649 RD3 LOC91548 NEK2 ENSG00000228792 FDPSP8
GH01G211646 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -69.9 -69877 4.7 SIN3A ARID4B GATA2 ZNF143 FOS NFYC REST PPARG TBX21 MIER3 SNORA16B SLC30A1 RD3 ENSG00000223649 NEK2 LOC91548 ENSG00000228792 FDPSP8
GH01G211610 1.6 Ensembl ENCODE dbSUPER 13.1 -34.2 -34192 4.3 HDGF PKNOX1 FOXA2 CREB3L1 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A1 LOC105372903 LINC01693
GH01G211630 1.6 Ensembl ENCODE dbSUPER 12.9 -52.1 -52148 1.7 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B FEZF1 ZNF2 ZNF766 CBX5 KLF13 SLC30A1 RCOR3 LINC01740 LINC01693 LOC105372903
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC30A1 on UCSC Golden Path with GeneCards custom track

Promoters for SLC30A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000019571 757 4001 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for SLC30A1 Gene

Chromosome:
1
Start:
211,571,568 bp from pter
End:
211,578,757 bp from pter
Size:
7,190 bases
Orientation:
Minus strand

Genomic View for SLC30A1 Gene

Genes around SLC30A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC30A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC30A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC30A1 Gene

Proteins for SLC30A1 Gene

  • Protein details for SLC30A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6M5-ZNT1_HUMAN
    Recommended name:
    Zinc transporter 1
    Protein Accession:
    Q9Y6M5
    Secondary Accessions:
    • Q0VAK9
    • Q9BZF6

    Protein attributes for SLC30A1 Gene

    Size:
    507 amino acids
    Molecular mass:
    55300 Da
    Quaternary structure:
    • Multimer.

neXtProt entry for SLC30A1 Gene

Post-translational modifications for SLC30A1 Gene

  • Glycosylation at Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC30A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC30A1 Gene

Domains & Families for SLC30A1 Gene

Gene Families for SLC30A1 Gene

Protein Domains for SLC30A1 Gene

Suggested Antigen Peptide Sequences for SLC30A1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6M5

UniProtKB/Swiss-Prot:

ZNT1_HUMAN :
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
Family:
  • Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
genes like me logo Genes that share domains with SLC30A1: view

Function for SLC30A1 Gene

Molecular function for SLC30A1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in zinc transport out of the cell.

Gene Ontology (GO) - Molecular Function for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0005515 protein binding IPI 18158319
GO:0008324 cation transmembrane transporter activity IEA --
GO:0019855 calcium channel inhibitor activity IEA,ISS --
genes like me logo Genes that share ontologies with SLC30A1: view
genes like me logo Genes that share phenotypes with SLC30A1: view

Animal Models for SLC30A1 Gene

MGI Knock Outs for SLC30A1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC30A1 Gene

Localization for SLC30A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC30A1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC30A1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
endoplasmic reticulum 5
golgi apparatus 5
extracellular 1
cytosol 1
lysosome 1
endosome 1

Gene Ontology (GO) - Cellular Components for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18158319
GO:0005783 endoplasmic reticulum IDA 18158319
GO:0005794 Golgi apparatus IDA 18158319
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC30A1: view

Pathways & Interactions for SLC30A1 Gene

genes like me logo Genes that share pathways with SLC30A1: view

Gene Ontology (GO) - Biological Process for SLC30A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0006829 zinc II ion transport IEA,ISS --
genes like me logo Genes that share ontologies with SLC30A1: view

No data available for SIGNOR curated interactions for SLC30A1 Gene

Drugs & Compounds for SLC30A1 Gene

(2) Drugs for SLC30A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC30A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC30A1: view

Transcripts for SLC30A1 Gene

mRNA/cDNA for SLC30A1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC30A1 Gene

Solute carrier family 30 (zinc transporter), member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC30A1 Gene

No ASD Table

Relevant External Links for SLC30A1 Gene

GeneLoc Exon Structure for
SLC30A1
ECgene alternative splicing isoforms for
SLC30A1

Expression for SLC30A1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC30A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC30A1 Gene

This gene is overexpressed in Liver (x6.0).

Protein differential expression in normal tissues from HIPED for SLC30A1 Gene

This gene is overexpressed in Liver (15.7), Placenta (9.9), Adrenal (7.2), Fetal Liver (6.5), and Frontal cortex (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC30A1 Gene



Protein tissue co-expression partners for SLC30A1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC30A1 Gene:

SLC30A1

SOURCE GeneReport for Unigene cluster for SLC30A1 Gene:

Hs.519469

Evidence on tissue expression from TISSUES for SLC30A1 Gene

  • Liver(2.8)
  • Nervous system(2.3)
  • Intestine(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with SLC30A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC30A1 Gene

Orthologs for SLC30A1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC30A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC30A1 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia SLC30A1 34 35
  • 93.01 (n)
cow
(Bos Taurus)
Mammalia SLC30A1 34 35
  • 92.06 (n)
rat
(Rattus norvegicus)
Mammalia Slc30a1 34
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Slc30a1 34 16 35
  • 83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC30A1 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC30A1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC30A1 34 35
  • 68.42 (n)
lizard
(Anolis carolinensis)
Reptilia SLC30A1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc30a1 34
  • 64.1 (n)
Str.18707 34
African clawed frog
(Xenopus laevis)
Amphibia slc30a1-prov 34
zebrafish
(Danio rerio)
Actinopterygii slc30a1a 34 35
  • 62.72 (n)
slc30a1b 35
  • 54 (a)
OneToMany
zgc77589 34
fruit fly
(Drosophila melanogaster)
Insecta ZnT63C 34 35
  • 52.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005918 34
  • 52.23 (n)
worm
(Caenorhabditis elegans)
Secernentea cdf-1 35
  • 24 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR129C 34
  • 50.73 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ZRC1 34 35
  • 48.35 (n)
COT1 35
  • 30 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F08723g 34
  • 47.28 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU03145 34
  • 49.08 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes zhf1 34
  • 48 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10885 35
  • 38 (a)
OneToOne
Species where no ortholog for SLC30A1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC30A1 Gene

ENSEMBL:
Gene Tree for SLC30A1 (if available)
TreeFam:
Gene Tree for SLC30A1 (if available)

Paralogs for SLC30A1 Gene

Paralogs for SLC30A1 Gene

(1) SIMAP similar genes for SLC30A1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC30A1: view

Variants for SLC30A1 Gene

Sequence variations from dbSNP and Humsavar for SLC30A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000008441 -- 211,579,219(+) ACCCC(A/C)GTTTT upstream-variant-2KB
rs1000267755 -- 211,579,035(+) AAGCT(A/C)CGAGC upstream-variant-2KB
rs1000724072 -- 211,578,745(+) AGGGG(C/G)CCCCG utr-variant-5-prime
rs1001366416 -- 211,579,363(+) AGGGG(C/T)GGGAA upstream-variant-2KB
rs1001530888 -- 211,574,988(+) CTATC(A/T)ATTAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for SLC30A1 Gene

Variant ID Type Subtype PubMed ID
dgv801n54 CNV loss 21841781
dgv802n54 CNV loss 21841781
dgv803n54 CNV loss 21841781
esv27192 CNV loss 19812545
nsv549125 CNV gain 21841781
nsv549129 CNV gain 21841781
nsv549137 CNV loss 21841781
nsv826542 CNV gain 20364138
nsv832514 CNV loss 17160897

Variation tolerance for SLC30A1 Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC30A1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC30A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC30A1 Gene

Disorders for SLC30A1 Gene

Relevant External Links for SLC30A1

Genetic Association Database (GAD)
SLC30A1
Human Genome Epidemiology (HuGE) Navigator
SLC30A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC30A1

No disorders were found for SLC30A1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC30A1 Gene

Publications for SLC30A1 Gene

  1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  2. Regulation of metallothioneins and ZnT-1 transporter expression in human hepatoma cells HepG2 exposed to zinc and cadmium. (PMID: 19900532) Urani C. … Gribaldo L. (Toxicol In Vitro 2010) 3 22 64
  3. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. (PMID: 20201890) Beharier O. … Moran A. (Ann. N. Y. Acad. Sci. 2010) 3 22 64
  4. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64
  5. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood H.D. … Lan Q. (Respir Med 2009) 3 46 64

Products for SLC30A1 Gene

Sources for SLC30A1 Gene

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