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SLC30A1 Gene

protein-coding   GIFtS: 59
GCID: GC01M211744

Solute Carrier Family 30 (Zinc Transporter), Member 1


(Previous symbol: ZNT1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 30 (Zinc Transporter), Member 11 2     Zinc Transporter 12
ZNT11 2 3 5     znT-12
Solute Carrier Family 30 Member 12 3     ZnT-13
ZRC12     

External Ids:    HGNC: 110121   Entrez Gene: 77792   Ensembl: ENSG000001703857   OMIM: 6095215   UniProtKB: Q9Y6M53   

Export aliases for SLC30A1 gene to outside databases

Previous GC identifers: GC01M210481 GC01M207611 GC01M208387 GC01M208828 GC01M208137 GC01M209811 GC01M182425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC30A1 Gene:
SLC30A1 (solute carrier family 30 (zinc transporter), member 1) is a protein-coding gene. Diseases associated with SLC30A1 include acrodermatitis, and enteropathica. GO annotations related to this gene include zinc ion transmembrane transporter activity and calcium channel inhibitor activity. An important paralog of this gene is SLC30A3.

UniProtKB/Swiss-Prot: ZNT1_HUMAN, Q9Y6M5
Function: May be involved in zinc transport out of the cell

Gene Wiki entry for SLC30A1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC30A1 gene promoter:
         Egr-3   Sox5   Pax-5   FOXD3   CUTL1   FOXL1   AREB6   Pax-3   Sox9   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for SLC30A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC30A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.3   Ensembl cytogenetic band:  1q32.3   HGNC cytogenetic band: 1q32.3

SLC30A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC30A1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M211744:  view genomic region     (about GC identifiers)

Start:
211,744,910 bp from pter      End:
211,752,099 bp from pter
Size:
7,190 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ZNT1_HUMAN, Q9Y6M5 (See protein sequence)
Recommended Name: Zinc transporter 1  
Size: 507 amino acids; 55300 Da
Subunit: Multimer (Probable)
Secondary accessions: Q0VAK9 Q9BZF6

Explore the universe of human proteins at neXtProt for SLC30A1: NX_Q9Y6M5

Explore proteomics data for SLC30A1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn299
  • Modification sites at PhosphoSitePlus

  • See SLC30A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067017.2  
    ENSEMBL proteins: 
     ENSP00000355968  
    Reactome Protein details: Q9Y6M5

    SLC30A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Zinc transporter 1
    SLC30 zinc transporter family

    2 InterPro protein domains:
     IPR027469 Cation_efflux_TMD
     IPR002524 Cation_efflux

    Graphical View of Domain Structure for InterPro Entry Q9Y6M5

    ProtoNet protein and cluster: Q9Y6M5

    1 Blocks protein domain: IPB002524 Cation efflux protein

    UniProtKB/Swiss-Prot: ZNT1_HUMAN, Q9Y6M5
    Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily


    SLC30A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ZNT1_HUMAN, Q9Y6M5
    Function: May be involved in zinc transport out of the cell

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005385zinc ion transmembrane transporter activity IEA--
    GO:0005515protein binding IPI18158319
    GO:0008324cation transmembrane transporter activity ----
    GO:0019855calcium channel inhibitor activity ISS--
         
    SLC30A1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Slc30a1):
     embryogenesis  mortality/aging  reproductive system 

    SLC30A1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC30A1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC30A1
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    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC30A1:
    hsa-mir-193b-3p (MIRT041483), hsa-mir-615-3p (MIRT039676), hsa-let-7b-5p (MIRT032247), hsa-mir-16-5p (MIRT031411), hsa-mir-155-5p (MIRT001501)

    Block miRNA regulation of human, mouse, rat SLC30A1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC30A1 (see all 13):
    hsa-miR-411* hsa-miR-892b hsa-miR-379* hsa-miR-548e hsa-miR-551b* hsa-miR-4294 hsa-miR-548a-3p hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC30A1

    Gene Editing
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC30A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ZNT1_HUMAN, Q9Y6M5: Cell membrane; Multi-pass membrane protein (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18158319
    GO:0005783endoplasmic reticulum IDA18158319
    GO:0005794Golgi apparatus IDA18158319
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    SLC30A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC30A1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    2Metal ion SLC transporters
    Metal ion SLC transporters
    Zinc transporters0.00
    Zinc efflux and compartmentalization by the SLC30 family0.00
    3Mineral absorption
    Mineral absorption

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC30A1
        Zinc efflux and compartmentalization by the SLC30 family


    1 Kegg Pathway  (Kegg details for SLC30A1):
        Mineral absorption


    SLC30A1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC30A1
    Interactions:

        Search GeneGlobe Interaction Network for SLC30A1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC30A1 (Q9Y6M53 ENSP000003559684) via UniProtKB, MINT, STRING, and/or I2D (see all 50)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPL37AP615133I2D: score=2 
    UBCENSP000003448184STRING: ENSP00000344818
    SPTLC1ENSP000002625544STRING: ENSP00000262554
    ATP9AENSP000003424814STRING: ENSP00000342481
    ATP9BENSP000003045004STRING: ENSP00000304500
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0006812cation transport ----
    GO:0006829zinc ion transport ISS--
    GO:0006874cellular calcium ion homeostasis ISS--
    GO:0006882cellular zinc ion homeostasis ISS--

    SLC30A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC30A1 (ZNT1)

    3 Novoseek inferred chemical compound relationships for SLC30A1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 77.7 101 9560190 (4), 15378655 (4), 15451416 (3), 9521625 (3) (see all 32)
    cadmium 29.4 1 14568174 (1)
    calcium 14.8 12 17196651 (3), 19059322 (1), 17971132 (1), 19767393 (1) (see all 6)



    SLC30A1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC30A1 gene: 
    NM_021194.2  

    Unigene Cluster for SLC30A1:

    Solute carrier family 30 (zinc transporter), member 1
    Hs.519469  [show with all ESTs]
    Unigene Representative Sequence: BX647120
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367001(uc001hio.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC30A1 (see all 13):
    hsa-miR-411* hsa-miR-892b hsa-miR-379* hsa-miR-548e hsa-miR-551b* hsa-miR-4294 hsa-miR-548a-3p hsa-miR-182
    SwitchGear 3'UTR luciferase reporter plasmidSLC30A1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC30A1
      QuantiFast Probe-based Assays in human, mouse, rat SLC30A1

    Additional mRNA sequence: 

    AB451467.1 AF364518.1 BC121015.1 BC121016.1 BX647120.1 

    3 DOTS entries:

    DT.456013  DT.75166694  DT.92422197 

    7 AceView cDNA sequences:

    AI621266 AW079607 AI467909 BE675653 AW183618 AI804642 AW195319 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC30A1 expression in normal human tissues (normalized intensities)      SLC30A1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGCTTTATG
    SLC30A1 Expression
    About this image


    SLC30A1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Liver (Hepatobiliary System)
    SLC30A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC30A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.519469
        Custom PCR Arrays for SLC30A1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC30A1 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc30a11 , 5 solute carrier family 30 (zinc transporter), member more1, 5 83(n)1
    85.46(a)1
      1 (97.01 cM)5
    227821  NM_009579.31  NP_033605.11 
     1919067675 
    chicken
    (Gallus gallus)
    Aves SLC30A11 solute carrier family 30 (zinc transporter), member more 68.42(n)
    61.78(a)
      421377  XM_419437.4  XP_419437.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC30A16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    1(238034214-238042154)
    African clawed frog
    (Xenopus laevis)
    Amphibia slc30a1-prov2 solute carrier family 30 (zinc transporter), member more 77.9(n)    BC046675.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc775892 hypothetical protein MGC77589 76.07(n)   393853  BC063939.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ZnT63C1 ZnT63C 52.79(n)
    47.84(a)
      38407  NM_168016.2  NP_728857.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cdf-16
    Protein CDF-1, isoform b (cdf-1) mRNA, complete cd...
    24(a)
    1 → many
    X(6499909-6504613) WBGene00000393
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ZRC11 ZRC1 48.35(n)
    41.93(a)
      855284   NP_013970.1 


    ENSEMBL Gene Tree for SLC30A1 (if available)
    TreeFam Gene Tree for SLC30A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC30A1 gene
    SLC30A32  SLC30A22  SLC30A82  SLC30A102  SLC30A42  
    1 SIMAP similar gene for SLC30A1 using alignment to 2 protein entries:     ZNT1_HUMAN (see all proteins):
    SLC30A10

    SLC30A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC30A1 (see all 103)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75312771,2
    C,F--211747902(+) CTTATA/TTATTT 1 -- ds5001 ese36Minor allele frequency- T:0.15WA CSA NA EA 364
    rs1879059521,2
    --211747942(+) ATACCA/GATCTT 1 -- ds50010--------
    rs1921479351,2
    --211747943(+) TACCAA/GTCTTT 1 -- ds50010--------
    rs75198651,2
    C,F,A,H--211748118(+) TGCCCC/TATTGT 1 -- ds5001 ese320Minor allele frequency- T:0.19NA NS EA WA CSA 1444
    rs1822901621,2
    --211748335(+) AATTAA/TAATTC 1 -- ds50010--------
    rs1873231901,2
    --211748514(+) TCCAAA/GACAGT 1 -- ut310--------
    rs2017904871,2
    C--211748686(+) TCCTCC/TTGCAG 1 -- ut310--------
    rs2010497091,2
    --211748718(+) CACATC/GTTTTT 1 -- ut310--------
    rs1917334771,2
    C--211748792(+) AGGGAA/TGTTTT 2 I F mis10--------
    rs2004636481,2
    --211748819(+) GGGCTG/TCTTCT 2 K Q mis10--------

    HapMap Linkage Disequilibrium report for SLC30A1 (211744910 - 211752099 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for SLC30A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832514CNV Loss17160897
    esv27192CNV Loss19812545
    nsv826542CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC30A1
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC30A1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609521    OMIM disorders: --

    17 diseases for SLC30A1:    About MalaCards
    acrodermatitis    enteropathica    acrodermatitis enteropathica    epidermodysplasia verruciformis
    lung cancer susceptibility    ischemia    coronary heart disease    prostate cancer
    obesity    alzheimer's disease    prostatitis    lung cancer
    hepatocellular carcinoma    malaria    cerebritis    breast cancer
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for SLC30A1:
    Epidermodysplasia verruciformis

    SLC30A1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for SLC30A1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 25.6 1 14568174 (1)
    ischemia 0 1 10801948 (1)

    Genetic Association Database (GAD): SLC30A1
    Human Genome Epidemiology (HuGE) Navigator: SLC30A1 (4 documents)

    Export disorders for SLC30A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC30A1 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with SLC30A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    2. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    3. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    4. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    5. Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study. (PubMed id 17971132)1, 9 Etzion Y....Katz A. (J. Cardiovasc. Electrophysiol. 2008)
    6. A role for ZnT-1 in regulating cellular cation influx. (PubMed id 15451416)1, 9 Segal D....Sekler I. (Biochem. Biophys. Res. Commun. 2004)
    7. Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. (PubMed id 16179263)1, 9 Lovell M.A....Markesbery W.R. (Neurotox Res 2005)
    8. The involvement of ZnT-1, a new modulator of cardiac L-type calcium channels, in [corrected] atrial tachycardia remodeling. [corrected]. (PubMed id 20201890)1, 9 Beharier O....Moran A. (Ann. N. Y. Acad. Sci. 2010)
    9. Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels. (PubMed id 19767393)1, 9 Levy S....Moran A. (J. Biol. Chem. 2009)
    10. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. (PubMed id 18158319)1, 9 Lazarczyk M....Favre M. (J. Exp. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7779 HGNC: 11012 AceView: SLC30A1.1 Ensembl:ENSG00000170385 euGenes: HUgn7779
    ECgene: SLC30A1 Kegg: 7779 H-InvDB: SLC30A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC30A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC30A1 gene:
    Search GeneIP for patents involving SLC30A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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