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Aliases for SLC2A9 Gene

Aliases for SLC2A9 Gene

  • Solute Carrier Family 2 Member 9 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 9 2 3 5
  • Urate Voltage-Driven Efflux Transporter 1 2 3
  • Glucose Transporter Type 9 3 4
  • GLUT-9 3 4
  • GLUT9 3 4
  • Human Glucose Transporter-Like Protein-9 3
  • UAQTL2 3
  • URATv1 3
  • GLUTX 3

External Ids for SLC2A9 Gene

Previous GeneCards Identifiers for SLC2A9 Gene

  • GC04M009497
  • GC04M009778
  • GC04M009578
  • GC04M009504
  • GC04M009827
  • GC04M009162

Summaries for SLC2A9 Gene

Entrez Gene Summary for SLC2A9 Gene

  • This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A9 Gene

SLC2A9 (Solute Carrier Family 2 Member 9) is a Protein Coding gene. Diseases associated with SLC2A9 include Hypouricemia, Renal, 2 and Hypouricemia, Renal. Among its related pathways are Uricosurics Pathway, Pharmacodynamics and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A9 Gene

  • Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Gene Wiki entry for SLC2A9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A9 Gene

Genomics for SLC2A9 Gene

Regulatory Elements for SLC2A9 Gene

Enhancers for SLC2A9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC2A9 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A9 Gene

9,771,125 bp from pter
10,054,936 bp from pter
283,812 bases
Minus strand

Genomic View for SLC2A9 Gene

Genes around SLC2A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A9 Gene

Proteins for SLC2A9 Gene

  • Protein details for SLC2A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 9
    Protein Accession:
    Secondary Accessions:
    • Q0VGC4
    • Q4W5D1
    • Q8WV30
    • Q96P00

    Protein attributes for SLC2A9 Gene

    540 amino acids
    Molecular mass:
    58702 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A9 Gene


neXtProt entry for SLC2A9 Gene

Proteomics data for SLC2A9 Gene at MOPED

Post-translational modifications for SLC2A9 Gene

  • Glycosylation at Asn 90
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A9 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for SLC2A9

No data available for DME Specific Peptides for SLC2A9 Gene

Domains & Families for SLC2A9 Gene

Gene Families for SLC2A9 Gene

Suggested Antigen Peptide Sequences for SLC2A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A9: view

Function for SLC2A9 Gene

Molecular function for SLC2A9 Gene

UniProtKB/Swiss-Prot Function:
Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Gene Ontology (GO) - Molecular Function for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 10860667
genes like me logo Genes that share ontologies with SLC2A9: view
genes like me logo Genes that share phenotypes with SLC2A9: view

Human Phenotype Ontology for SLC2A9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC2A9 Gene

MGI Knock Outs for SLC2A9:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC2A9 Gene

Localization for SLC2A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A9 Gene

Isoform 1: Basolateral cell membrane; Multi-pass membrane protein.
Isoform 2: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC2A9 Gene COMPARTMENTS Subcellular localization image for SLC2A9 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A9: view

Pathways & Interactions for SLC2A9 Gene

genes like me logo Genes that share pathways with SLC2A9: view

Interacting Proteins for SLC2A9 Gene

Gene Ontology (GO) - Biological Process for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046415 urate metabolic process IMP 18834626
GO:1904659 glucose transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A9: view

No data available for SIGNOR curated interactions for SLC2A9 Gene

Drugs & Compounds for SLC2A9 Gene

(7) Drugs for SLC2A9 Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Losartan Approved Pharma Antagonist, Transporter, inhibitor 277
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 27
Canagliflozin Approved Pharma Inhibition, Inhibitor SGLT2 inhibitor,potent and selective 98
Uric Acid Experimental, Investigational Pharma Transporter, substrate 123
Hypoglycemic Agents Pharma 5465

(2) Additional Compounds for SLC2A9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A9: view

Transcripts for SLC2A9 Gene

mRNA/cDNA for SLC2A9 Gene

Unigene Clusters for SLC2A9 Gene

Solute carrier family 2 (facilitated glucose transporter), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP4: -

Relevant External Links for SLC2A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A9 Gene

mRNA expression in normal human tissues for SLC2A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A9 Gene

This gene is overexpressed in Kidney - Cortex (x9.4).

Protein differential expression in normal tissues from HIPED for SLC2A9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Urine (18.9), Fetal Liver (13.4), and Kidney (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A9 Gene

SOURCE GeneReport for Unigene cluster for SLC2A9 Gene Hs.656895

mRNA Expression by UniProt/SwissProt for SLC2A9 Gene

Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).
genes like me logo Genes that share expression patterns with SLC2A9: view

Protein tissue co-expression partners for SLC2A9 Gene

Primer Products

Orthologs for SLC2A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia SLC2A9 35
  • 83.54 (n)
  • 82.04 (a)
SLC2A9 36
  • 83 (a)
(Canis familiaris)
Mammalia SLC2A9 35
  • 86.47 (n)
  • 86.34 (a)
SLC2A9 36
  • 80 (a)
(Mus musculus)
Mammalia Slc2a9 35
  • 82.34 (n)
  • 85.26 (a)
Slc2a9 16
Slc2a9 36
  • 81 (a)
(Pan troglodytes)
Mammalia SLC2A9 35
  • 99.1 (n)
  • 98.75 (a)
SLC2A9 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Slc2a9 35
  • 83 (n)
  • 85.63 (a)
(Monodelphis domestica)
Mammalia SLC2A9 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A9 36
  • 77 (a)
(Gallus gallus)
Aves SLC2A9 35
  • 68.8 (n)
  • 75.05 (a)
SLC2A9 36
  • 68 (a)
(Anolis carolinensis)
Reptilia SLC2A9 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a9 35
  • 63.22 (n)
  • 66.92 (a)
Str.17199 35
(Danio rerio)
Actinopterygii slc2a15a 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta sut2 37
  • 27 (a)
sut3 37
  • 26 (a)
(Caenorhabditis elegans)
Secernentea K08F9.1 37
  • 25 (a)
Y37A1A.3 37
  • 23 (a)
Y61A9LA.1 37
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
Species with no ortholog for SLC2A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A9 Gene

Gene Tree for SLC2A9 (if available)
Gene Tree for SLC2A9 (if available)

Paralogs for SLC2A9 Gene

(11) SIMAP similar genes for SLC2A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A9: view

Variants for SLC2A9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A9 Gene

Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076]. Excess serum accumulation of uric acid can lead to the development of gout.

Sequence variations from dbSNP and Humsavar for SLC2A9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs2276961 - 10,021,357(-) ACGCC(A/G)GGCCT intron-variant, nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs16890979 - 9,920,543(+) GGAAA(C/T)GTCTG nc-transcript-variant, reference, missense
rs2280205 - 9,908,299(+) TTGCC(A/C/G)GAGGG nc-transcript-variant, reference, missense
rs3733591 - 9,920,506(-) GAGCC(A/G)CGTGC nc-transcript-variant, reference, missense
VAR_045648 -

Structural Variations from Database of Genomic Variants (DGV) for SLC2A9 Gene

Variant ID Type Subtype PubMed ID
dgv1570e1 CNV Complex 17122850
nsv878667 CNV Gain 21882294
dgv5473n71 CNV Gain 21882294
dgv5474n71 CNV Gain 21882294
nsv878673 CNV Gain 21882294
dgv5475n71 CNV Gain 21882294
dgv5476n71 CNV Gain 21882294
nsv878682 CNV Gain 21882294
nsv10449 CNV Gain 18304495
nsv461259 CNV Loss 19166990
nsv878683 CNV Gain 21882294
nsv433443 CNV Loss 18776910
esv24465 CNV Loss 19812545
esv2669053 CNV Deletion 23128226
nsv519519 CNV Loss 19592680
nsv524654 CNV Loss 19592680
nsv878684 CNV Gain 21882294
esv2727156 CNV Deletion 23290073
esv25020 CNV Loss 19812545
nsv878685 CNV Gain 21882294
dgv5477n71 CNV Gain 21882294
esv2752052 CNV Gain 17911159
nsv527211 CNV Loss 19592680
esv2727157 CNV Deletion 23290073
esv2727158 CNV Deletion 23290073
nsv525177 CNV Loss 19592680
dgv5478n71 CNV Gain 21882294
esv2727159 CNV Deletion 23290073
esv2162646 CNV Deletion 18987734
esv2727160 CNV Deletion 23290073
esv2757 CNV Deletion 18987735
esv2470501 CNV Deletion 19546169
nsv290026 CNV Loss 16902084
esv2217569 CNV Deletion 18987734
esv2727161 CNV Deletion 23290073
dgv135n6 CNV Loss 16902084
nsv527147 CNV Gain 19592680
esv2425297 CNV Insertion 19546169
nsv829857 CNV Gain 17160897
nsv469621 CNV Loss 16826518

Variation tolerance for SLC2A9 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.85; 96.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A9 Gene

Human Gene Mutation Database (HGMD)

Disorders for SLC2A9 Gene

MalaCards: The human disease database

(10) MalaCards diseases for SLC2A9 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypouricemia, renal, 2
  • uric acid concentration, serum, qtl 2
hypouricemia, renal
  • renal hypouricemia
  • articular gout
  • calculus of kidney and ureter
acquired polycythemia
  • polycythemia, secondary
- elite association - COSMIC cancer census association via MalaCards


  • Hypouricemia renal 2 (RHUC2) [MIM:612076]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO:0000269 PubMed:19026395, ECO:0000269 PubMed:19926891, ECO:0000269 PubMed:21810765}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC2A9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC2A9: view

No data available for Genatlas for SLC2A9 Gene

Publications for SLC2A9 Gene

  1. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PMID: 10860667) Phay J.E. … Moley J.F. (Genomics 2000) 2 3 4 23 67
  2. Homozygous SLC2A9 mutations cause severe renal hypouricemia. (PMID: 19926891) Dinour D. … Holtzman E.J. (J. Am. Soc. Nephrol. 2010) 3 23
  3. Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (PMID: 20162745) Polasek O. … Lauc G. (Croat. Med. J. 2010) 3 23
  4. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PMID: 18327257) Vitart V. … Wright A.F. (Nat. Genet. 2008) 3 25
  5. Plasma urate level is directly regulated by a voltage-driven urate efflux transporter URATv1 (SLC2A9) in humans. (PMID: 18701466) Anzai N. … Sakurai H. (J. Biol. Chem. 2008) 3 23

Products for SLC2A9 Gene

Sources for SLC2A9 Gene