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SLC2A9 Gene

protein-coding   GIFtS: 57
GCID: GC04M009772

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

  See SLC2A9-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 91 2     UAQTL22 5
GLUT92 3 5     GLUTX2
Urate Voltage-Driven Efflux Transporter 11 2     URATv12
Glucose Transporter Type 92 3     Human Glucose Transporter-Like Protein-92
GLUT-92 3     Solute Carrier Family 2, Facilitated Glucose Transporter Member 92

External Ids:    HGNC: 134461   Entrez Gene: 566062   Ensembl: ENSG000001096677   OMIM: 6061425   UniProtKB: Q9NRM03   

Export aliases for SLC2A9 gene to outside databases

Previous GC identifers: GC04M009497 GC04M009778 GC04M009578 GC04M009504 GC04M009827 GC04M009162


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A9 Gene:
This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a
significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and
survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been
identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for SLC2A9 Gene:
SLC2A9 (solute carrier family 2 (facilitated glucose transporter), member 9) is a protein-coding gene. Diseases associated with SLC2A9 include renal hypouricemia 2, and uric acid concentration, serum, qtl 2. GO annotations related to this gene include sugar:hydrogen symporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also
transports glucose at low rate

Gene Wiki entry for SLC2A9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A9 gene promoter:
         Pax-5   Pax-6   Pax-2   Pax-2a   LUN-1   Ik-3   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A9 promoter sequence
   Search Chromatin IP Primers for SLC2A9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

SLC2A9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A9 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M009772:  view genomic region     (about GC identifiers)

Start:
9,772,777 bp from pter      End:
10,056,560 bp from pter
Size:
283,784 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 9  
Size: 540 amino acids; 58702 Da
Secondary accessions: Q0VGC4 Q4W5D1 Q8WV30 Q96P00
Alternative splicing: 2 isoforms:  Q9NRM0-1   Q9NRM0-2   (Variant in position: 17:A->T (in dbSNP:6820230))

Explore the universe of human proteins at neXtProt for SLC2A9: NX_Q9NRM0

Explore proteomics data for SLC2A9 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn90
  • Modification sites at PhosphoSitePlus

  • See SLC2A9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001290.1  NP_064425.2  

    ENSEMBL proteins: 
     ENSP00000264784   ENSP00000422209   ENSP00000426800   ENSP00000311383  
    Reactome Protein details: Q9NRM0

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 9
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NRM0

    ProtoNet protein and cluster: Q9NRM0

    2 Blocks protein domains:
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR9_HUMAN, Q9NRM0
    Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also
    transports glucose at low rate

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005351sugar:hydrogen symporter activity NAS10860667
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC2A9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A9:
     Decreased POU5F1-GFP protein e 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a9):
     behavior/neurological  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    Find genes that share phenotypes with SLC2A9           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc2a9tm1.2Thor for SLC2A9

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A9
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR9_HUMAN, Q9NRM0: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus2
    peroxisome2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005635nuclear envelope IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane NAS10860667

    Find genes that share ontologies with SLC2A9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A9 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Facilitative Na+-independent glucose transporters0.00
    Transmembrane transport of small molecules0.47
    Class II GLUTs0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3Uric Acid-Lowering Drugs Pathway, Pharmacodynamics
    Uric Acid-Lowering Drugs Pathway, Pharmacodynamics


    Find genes that share SuperPaths with SLC2A9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC2A9
        Antioxidant Action of Vitamin-C

    1 Reactome Pathway for SLC2A9
        Class II GLUTs

    1 PharmGKB Pathway for SLC2A9
        Uric Acid-Lowering Drugs Pathway, Pharmacodynamics

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A9
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A9

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015758glucose transport NAS10860667
    GO:0015992proton transport NAS10860667
    GO:0046415urate metabolic process IMP18834626
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC2A9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A9 (GTR9)

    4 Novoseek inferred chemical compound relationships for SLC2A9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cytochalasin b 59.5 9 14739288 (1)
    2-deoxyglucose 54.5 5 14739288 (2)
    glucose 47.7 16 20162745 (2), 15943951 (2), 10860667 (2), 11780753 (1) (see all 7)
    fructose 47.3 1 11780753 (1)



    Find genes that share compounds with SLC2A9           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC2A9 gene (2 alternative transcripts): 
    NM_001001290.1  NM_020041.2  

    Unigene Cluster for SLC2A9:

    Solute carrier family 2 (facilitated glucose transporter), member 9
    Hs.656895  [show with all ESTs]
    Unigene Representative Sequence: AK096819
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508585 ENST00000503803 ENST00000512342 ENST00000503280 ENST00000264784(uc003gmc.3)
    ENST00000506583(uc003gmd.3) ENST00000505104 ENST00000513129 ENST00000506839
    ENST00000505506 ENST00000509214 ENST00000481042(uc003gme.1) ENST00000309065

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    Additional mRNA sequence: 

    AF210317.1 AF421859.1 AK096819.1 AK310895.1 BC018897.2 BC110414.1 

    8 DOTS entries:

    DT.110094  DT.100745107  DT.75100908  DT.439537  DT.307960  DT.75194662  DT.91907721  DT.65286643 

    10 AceView cDNA sequences:

    AA228138 AW451509 AA227974 BE326892 AK025887 W51903 W48668 BX111149 
    AI863532 BE326912 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
    SP1:              -     -                             -     -                                                   
    SP2:                    -                             -     -                                                   
    SP3:                                                                                                            
    SP4:                                -                                                                           


    ECgene alternative splicing isoforms for SLC2A9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC2A9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    SLC2A9 Expression
    About this image


    SLC2A9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
    SLC2A9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.656895

    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
    Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and
    placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular
    cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta.
    Isoform 1 and isoform 2 are detected in kidney membrane (at protein level)

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC2A9 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a91 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 82.34(n)1
    85.26(a)1
      5 (20.43 cM)5
    1175911  NM_001102414.11  NP_001095884.11 
     383492735 
    chicken
    (Gallus gallus)
    Aves SLC2A91 solute carrier family 2 (facilitated glucose transporter), more 68.8(n)
    75.05(a)
      422843  XM_420789.4  XP_420789.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A96
    solute carrier family 2 (facilitated glucose trans...
    66(a)
    1 ↔ 1
    GL343236.1(440323-516732)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.171992 Transcribed sequence with weak similarity to protein more 74.42(n)    BX760056.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CA496350.12   -- 72.32(n)    CA496350.1 


    ENSEMBL Gene Tree for SLC2A9 (if available)
    TreeFam Gene Tree for SLC2A9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A9 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A32  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    11 SIMAP similar genes for SLC2A9 using alignment to 2 protein entries:     GTR9_HUMAN (see all proteins):
    SLC2A5    SLC2A11    SLC2A7    SLC2A11-a    SLC2A11-c    SLC2A1
    SLC2A4    SLC2A3    SLC2A14    SLC2A2    SLC2A10

    Find genes that share paralogs with SLC2A9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    GTR9_HUMAN, Q9NRM0: Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the
    serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076]. Excess serum accumulation of uric
    acid can lead to the development of gout


    Selected SNPs for SLC2A9 (see all 5527)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815095911,2,,4
    CHypouricemia renal 2 (RHUC2)4 --9948384(+) TTAACA/GTCCCC 4 T M mis10--------
    VAR_0657744
    Hypouricemia renal 2 (RHUC2)4--see VAR_0657742 R C mis40--------
    VAR_0657724
    Hypouricemia renal 2 (RHUC2)4--see VAR_0657722 L R mis40--------
    VAR_0657754
    Hypouricemia renal 2 (RHUC2)4--see VAR_0657752 R C mis40--------
    VAR_0657764
    Hypouricemia renal 2 (RHUC2)4--see VAR_0657762 R W mis40--------
    rs1219083211,2
    Cpathogenic19842171(-) TGGGAA/C/TGGAGA 4 R W mis10--------
    rs1219083221,2
    Cpathogenic19932243(-) AGATCC/TGTGGC 4 R C mis10--------
    rs9385571,2
    C,F,H--9777423(+) TGGGAC/TCCAGG 2 -- ds500127Minor allele frequency- T:0.14MN NS EA NA WA CSA 2539
    rs1808594331,2
    --9777496(+) AATCCC/GTTGAG 2 -- ds50010--------
    rs1995276341,2
    --9777551(+) CTACT-/ATT   
      TCCCCA
    ATTTC
    2 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC2A9 (9772777 - 10022777 bp, first 250kb of SLC2A9)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC2A9 (see all 40):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2217569CNV Deletion18987734
    esv2727160CNV Deletion23290073
    esv2727159CNV Deletion23290073
    esv2757CNV Deletion18987735
    esv2727158CNV Deletion23290073
    esv2162646CNV Deletion18987734
    esv2727161CNV Deletion23290073
    esv2470501CNV Deletion19546169
    esv2669053CNV Deletion23128226
    esv2727157CNV Deletion23290073

    Human Gene Mutation Database (HGMD): SLC2A9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A9
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 606142   
    OMIM disorders: 612076  
    UniProtKB/Swiss-Prot: GTR9_HUMAN, Q9NRM0
  • Hypouricemia renal 2 (RHUC2) [MIM:612076]: A disorder characterized by impaired uric acid reabsorption at
    the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear
    asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and
    nephrolithiasis. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for SLC2A9:    
    About MalaCards
    renal hypouricemia 2    uric acid concentration, serum, qtl 2    renal hypouricemia

    3 diseases from the University of Copenhagen DISEASES database for SLC2A9:
    Gout     Hyperuricemia     Nephrolithiasis

    Find genes that share disorders with SLC2A9           About GenesLikeMe

    Genetic Association Database (GAD): SLC2A9
    Human Genome Epidemiology (HuGE) Navigator: SLC2A9 (28 documents)

    Export disorders for SLC2A9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC2A9 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with SLC2A9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PubMed id 10860667)1, 2, 3, 9 Phay J.E.... Moley J.F. (Genomics 2000)
    2. SLC2A9 influences uric acid concentrations with pronounced sex- specific effects. (PubMed id 18327256)1, 2, 4 Doering A.... Meisinger C. (Nat. Genet. 2008)
    3. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PubMed id 18327257)1, 2, 4 Vitart V.... Wright A.F. (Nat. Genet. 2008)
    4. Identification and characterization of human glucose transporter-like protein-9 (GLUT9): alternative splicing alters trafficking. (PubMed id 14739288)1, 2, 9 Augustin R....Moley K.H. (J. Biol. Chem. 2004)
    5. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. (PubMed id 19026395)1, 2, 9 Matsuo H....Shinomiya N. (Am. J. Hum. Genet. 2008)
    6. Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (PubMed id 20162745)1, 4, 9 Polasek O....Lauc G. (Croat. Med. J. 2010)
    7. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. (PubMed id 11991658)1, 2, 9 Mobasheri A.... Carter S.D. (Cell Biol. Int. 2002)
    8. Homozygous SLC2A9 mutations cause severe renal hypouricemia. (PubMed id 19926891)1, 2, 9 Dinour D.... Holtzman E.J. (J. Am. Soc. Nephrol. 2010)
    9. Genome-wide association study of Alzheimer's disease with psychotic symptoms. (PubMed id 22005930)1, 4 Hollingworth P....Williams J. (Mol. Psychiatry 2012)
    10. Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia. (PubMed id 22229870)1, 4 Karns R....Deka R. (Ann. Hum. Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56606 HGNC: 13446 AceView: SLC2A9.1 Ensembl:ENSG00000109667 euGenes: HUgn56606
    ECgene: SLC2A9 H-InvDB: SLC2A9

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC2A9 gene:
    Search GeneIP for patents involving SLC2A9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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