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Aliases for SLC2A9 Gene

Aliases for SLC2A9 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 9 2 3
  • GLUT9 3 4 6
  • Urate Voltage-Driven Efflux Transporter 1 2 3
  • Glucose Transporter Type 9 3 4
  • UAQTL2 3 6
  • GLUT-9 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 9 3
  • Human Glucose Transporter-Like Protein-9 3
  • URATv1 3
  • GLUTX 3

External Ids for SLC2A9 Gene

Summaries for SLC2A9 Gene

Entrez Gene Summary for SLC2A9 Gene

  • This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A9 Gene

SLC2A9 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 9) is a Protein Coding gene. Diseases associated with SLC2A9 include hypouricemia, renal, 2 and hypouricemia, renal. Among its related pathways are PAK Pathway and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include glucose transmembrane transporter activity and sugar:proton symporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A9 Gene

  • Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Gene Wiki entry for SLC2A9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A9 Gene

Genomics for SLC2A9 Gene

Genomic Location for SLC2A9 Gene

Start:
9,771,153 bp from pter
End:
10,054,936 bp from pter
Size:
283,784 bases
Orientation:
Minus strand

Genomic View for SLC2A9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A9 Gene

Regulatory Elements for SLC2A9 Gene

Proteins for SLC2A9 Gene

  • Protein details for SLC2A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRM0-GTR9_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 9
    Protein Accession:
    Q9NRM0
    Secondary Accessions:
    • Q0VGC4
    • Q4W5D1
    • Q8WV30
    • Q96P00

    Protein attributes for SLC2A9 Gene

    Size:
    540 amino acids
    Molecular mass:
    58702 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A9 Gene

Proteomics data for SLC2A9 Gene at MOPED

Post-translational modifications for SLC2A9 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn90

Other Protein References for SLC2A9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A9 Gene

Domains for SLC2A9 Gene

Gene Families for SLC2A9 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

GTR9_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.:
    • Q9NRM0
genes like me logo Genes that share domains with SLC2A9: view

Function for SLC2A9 Gene

Molecular function for SLC2A9 Gene

UniProtKB/Swiss-Prot Function: Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Gene Ontology (GO) - Molecular Function for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 10860667
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A9: view
genes like me logo Genes that share phenotypes with SLC2A9: view

Animal Models for SLC2A9 Gene

MGI Knock Outs for SLC2A9:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC2A9 Gene

Localization for SLC2A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A9 Gene

Isoform 1: Basolateral cell membrane; Multi-pass membrane protein.
Isoform 2: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A9 Gene COMPARTMENTS Subcellular localization image for SLC2A9 gene
Compartment Confidence
plasma membrane 4
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane NAS 10860667
genes like me logo Genes that share ontologies with SLC2A9: view

Pathways for SLC2A9 Gene

genes like me logo Genes that share pathways with SLC2A9: view

Interacting Proteins for SLC2A9 Gene

Gene Ontology (GO) - Biological Process for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015758 glucose transport NAS 10860667
GO:0015992 proton transport NAS 10860667
GO:0035428 hexose transmembrane transport IBA --
GO:0046323 glucose import IBA --
GO:0046415 urate metabolic process IMP 18834626
genes like me logo Genes that share ontologies with SLC2A9: view

Compounds for SLC2A9 Gene

(4) Novoseek inferred chemical compound relationships for SLC2A9 Gene

Compound -log(P) Hits PubMed IDs
cytochalasin b 59.5 1
2-deoxyglucose 54.5 2
glucose 47.7 10
fructose 47.3 1
genes like me logo Genes that share compounds with SLC2A9: view

Transcripts for SLC2A9 Gene

mRNA/cDNA for SLC2A9 Gene

(17) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SLC2A9 Gene

Solute carrier family 2 (facilitated glucose transporter), member 9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP3:
SP4: -

Relevant External Links for SLC2A9 Gene

GeneLoc Exon Structure for
SLC2A9
ECgene alternative splicing isoforms for
SLC2A9

Expression for SLC2A9 Gene

mRNA expression in normal human tissues for SLC2A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A9 Gene

This gene is overexpressed in Kidney - Cortex (9.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC2A9 Gene

SOURCE GeneReport for Unigene cluster for SLC2A9 Gene Hs.656895

mRNA Expression by UniProt/SwissProt for SLC2A9 Gene

Q9NRM0-GTR9_HUMAN
Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).
genes like me logo Genes that share expressions with SLC2A9: view

Orthologs for SLC2A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A9 36
  • 99.1 (n)
  • 98.75 (a)
SLC2A9 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A9 36
  • 83.54 (n)
  • 82.04 (a)
SLC2A9 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A9 36
  • 86.47 (n)
  • 86.34 (a)
SLC2A9 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a9 36
  • 82.34 (n)
  • 85.26 (a)
Slc2a9 16
Slc2a9 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A9 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A9 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a9 36
  • 83 (n)
  • 85.63 (a)
chicken
(Gallus gallus)
Aves SLC2A9 36
  • 68.8 (n)
  • 75.05 (a)
SLC2A9 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A9 37
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a9 36
  • 63.22 (n)
  • 66.92 (a)
Str.17199 36
zebrafish
(Danio rerio)
Actinopterygii slc2a15a 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta sut3 38
  • 26 (a)
sut2 38
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea Y61A9LA.1 38
  • 24 (a)
Y37A1A.3 38
  • 23 (a)
K08F9.1 38
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for SLC2A9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A9 Gene

ENSEMBL:
Gene Tree for SLC2A9 (if available)
TreeFam:
Gene Tree for SLC2A9 (if available)

Paralogs for SLC2A9 Gene

Selected SIMAP similar genes for SLC2A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A9: view

Variants for SLC2A9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A9 Gene

Q9NRM0-GTR9_HUMAN
Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076]. Excess serum accumulation of uric acid can lead to the development of gout

Sequence variations from dbSNP and Humsavar for SLC2A9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2066 -- 9,823,250(-) CCTAA(C/T)TCCTG intron-variant
rs4144 -- 10,014,698(+) GCCTG(C/T)CTCAC intron-variant
rs734553 -- 9,921,380(-) CTTTC(A/C)GGGAT intron-variant
rs737267 -- 9,933,120(+) AACTG(G/T)CTCTG intron-variant
rs746082 -- 9,911,663(+) GTGAC(A/C/T)GCAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A9 Gene

Variant ID Type Subtype PubMed ID
dgv1570e1 CNV Complex 17122850
nsv878667 CNV Gain 21882294
dgv5473n71 CNV Gain 21882294
dgv5474n71 CNV Gain 21882294
nsv878673 CNV Gain 21882294
dgv5475n71 CNV Gain 21882294
dgv5476n71 CNV Gain 21882294
nsv878682 CNV Gain 21882294
nsv10449 CNV Gain 18304495
nsv461259 CNV Loss 19166990
nsv878683 CNV Gain 21882294
nsv433443 CNV Loss 18776910
esv24465 CNV Loss 19812545
esv2669053 CNV Deletion 23128226
nsv519519 CNV Loss 19592680
nsv524654 CNV Loss 19592680
nsv878684 CNV Gain 21882294
esv2727156 CNV Deletion 23290073
esv25020 CNV Loss 19812545
nsv878685 CNV Gain 21882294
dgv5477n71 CNV Gain 21882294
esv2752052 CNV Gain 17911159
nsv527211 CNV Loss 19592680
esv2727157 CNV Deletion 23290073
esv2727158 CNV Deletion 23290073
nsv525177 CNV Loss 19592680
dgv5478n71 CNV Gain 21882294
esv2727159 CNV Deletion 23290073
esv2162646 CNV Deletion 18987734
esv2727160 CNV Deletion 23290073
esv2757 CNV Deletion 18987735
esv2470501 CNV Deletion 19546169
nsv290026 CNV Loss 16902084
esv2217569 CNV Deletion 18987734
esv2727161 CNV Deletion 23290073
dgv135n6 CNV Loss 16902084
nsv527147 CNV Gain 19592680
esv2425297 CNV Insertion 19546169
nsv829857 CNV Gain 17160897
nsv469621 CNV Loss 16826518

Relevant External Links for SLC2A9 Gene

HapMap Linkage Disequilibrium report
SLC2A9
Human Gene Mutation Database (HGMD)
SLC2A9

Disorders for SLC2A9 Gene

(1) OMIM Diseases for SLC2A9 Gene (606142)

UniProtKB/Swiss-Prot

GTR9_HUMAN
  • Hypouricemia renal 2 (RHUC2) [MIM:612076]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO:0000269 PubMed:19026395, ECO:0000269 PubMed:19926891, ECO:0000269 PubMed:21810765}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for SLC2A9 Gene

Relevant External Links for SLC2A9

Genetic Association Database (GAD)
SLC2A9
Human Genome Epidemiology (HuGE) Navigator
SLC2A9
genes like me logo Genes that share disorders with SLC2A9: view

Publications for SLC2A9 Gene

  1. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PMID: 10860667) Phay J.E. … Moley J.F. (Genomics 2000) 2 3 4 23
  2. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. (PMID: 11991658) Mobasheri A. … Carter S.D. (Cell Biol. Int. 2002) 3 4 23
  3. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. (PMID: 19026395) Matsuo H. … Shinomiya N. (Am. J. Hum. Genet. 2008) 3 4 23
  4. Homozygous SLC2A9 mutations cause severe renal hypouricemia. (PMID: 19926891) Dinour D. … Holtzman E.J. (J. Am. Soc. Nephrol. 2010) 3 4 23
  5. Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (PMID: 20162745) Polasek O. … Lauc G. (Croat. Med. J. 2010) 3 23 49

Products for SLC2A9 Gene

Sources for SLC2A9 Gene

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