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Aliases for SLC2A8 Gene

Aliases for SLC2A8 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 8 2 3
  • GLUT8 3 4 6
  • Glucose Transporter Type X1 3 4
  • Glucose Transporter Type 8 3 4
  • GLUTX1 3 4
  • Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 8 2
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 8 3
  • GLUT-8 4

External Ids for SLC2A8 Gene

Previous GeneCards Identifiers for SLC2A8 Gene

  • GC09P121274
  • GC09P121806
  • GC09P123613
  • GC09P125535
  • GC09P127239
  • GC09P129199
  • GC09P130159
  • GC09P099775

Summaries for SLC2A8 Gene

Entrez Gene Summary for SLC2A8 Gene

  • This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC2A8 Gene

SLC2A8 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include glucose transmembrane transporter activity and glucose binding. An important paralog of this gene is SLC2A6.

UniProtKB/Swiss-Prot for SLC2A8 Gene

  • Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A8 Gene

Genomics for SLC2A8 Gene

Regulatory Elements for SLC2A8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC2A8 Gene

Start:
127,397,138 bp from pter
End:
127,408,424 bp from pter
Size:
11,287 bases
Orientation:
Plus strand

Genomic View for SLC2A8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A8 Gene

Proteins for SLC2A8 Gene

  • Protein details for SLC2A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY64-GTR8_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 8
    Protein Accession:
    Q9NY64
    Secondary Accessions:
    • Q8WUZ9
    • Q9NSC4

    Protein attributes for SLC2A8 Gene

    Size:
    477 amino acids
    Molecular mass:
    50819 Da
    Quaternary structure:
    • Interacts with AP2B1.

neXtProt entry for SLC2A8 Gene

Proteomics data for SLC2A8 Gene at MOPED

Post-translational modifications for SLC2A8 Gene

No data available for DME Specific Peptides for SLC2A8 Gene

Domains for SLC2A8 Gene

Gene Families for SLC2A8 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

Q9NY64

UniProtKB/Swiss-Prot:

GTR8_HUMAN :
  • Q9NY64
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A8: view

Function for SLC2A8 Gene

Molecular function for SLC2A8 Gene

UniProtKB/Swiss-Prot Function: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).
UniProtKB/Swiss-Prot Induction: In testis, down-regulated by estrogen

Gene Ontology (GO) - Molecular Function for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IEA --
GO:0005536 glucose binding IEA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A8: view
genes like me logo Genes that share phenotypes with SLC2A8: view

Animal Models for SLC2A8 Gene

MGI Knock Outs for SLC2A8:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC2A8 Gene

Localization for SLC2A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A8 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A8 Gene COMPARTMENTS Subcellular localization image for SLC2A8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with SLC2A8: view

Pathways for SLC2A8 Gene

genes like me logo Genes that share pathways with SLC2A8: view

Interacting Proteins for SLC2A8 Gene

Gene Ontology (GO) - Biological Process for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS 10671487
GO:0007141 male meiosis I IEA --
GO:0008286 insulin receptor signaling pathway IEA --
GO:0008643 carbohydrate transport --
genes like me logo Genes that share ontologies with SLC2A8: view

Compounds for SLC2A8 Gene

(1) Novoseek inferred chemical compound relationships for SLC2A8 Gene

Compound -log(P) Hits PubMed IDs
glucose 43 16
genes like me logo Genes that share compounds with SLC2A8: view

Transcripts for SLC2A8 Gene

Unigene Clusters for SLC2A8 Gene

Solute carrier family 2 (facilitated glucose transporter), member 8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC2A8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8: - - - -
SP9:
SP10:

Relevant External Links for SLC2A8 Gene

GeneLoc Exon Structure for
SLC2A8
ECgene alternative splicing isoforms for
SLC2A8

Expression for SLC2A8 Gene

mRNA expression in normal human tissues for SLC2A8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC2A8 Gene

SOURCE GeneReport for Unigene cluster for SLC2A8 Gene Hs.179522

mRNA Expression by UniProt/SwissProt for SLC2A8 Gene

Q9NY64-GTR8_HUMAN
Tissue specificity: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues
genes like me logo Genes that share expressions with SLC2A8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SLC2A8 Gene

Orthologs for SLC2A8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A8 35
  • 99.58 (n)
  • 99.37 (a)
SLC2A8 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A8 35
  • 88.19 (n)
  • 89.1 (a)
SLC2A8 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A8 35
  • 88.12 (n)
  • 88.89 (a)
SLC2A8 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a8 35
  • 85.5 (n)
  • 86.55 (a)
Slc2a8 16
Slc2a8 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A8 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A8 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a8 35
  • 85.46 (n)
  • 85.53 (a)
chicken
(Gallus gallus)
Aves SLC2A8 35
  • 60.34 (n)
  • 60.13 (a)
SLC2A8 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A8 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486943 35
  • 65.5 (n)
  • 64.41 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17429 35
slc2a8 35
  • 61.35 (n)
  • 59.79 (a)
slc2a8 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10960 36
  • 32 (a)
ManyToMany
CG1208 36
  • 31 (a)
ManyToMany
CG1213 36
  • 30 (a)
ManyToMany
CG14605 36
  • 23 (a)
ManyToMany
CG14606 36
  • 24 (a)
ManyToMany
CG15406 36
  • 26 (a)
ManyToMany
CG15408 36
  • 23 (a)
ManyToMany
CG31100 36
  • 15 (a)
ManyToMany
CG3285 36
  • 25 (a)
ManyToMany
CG33281 36
  • 27 (a)
ManyToMany
CG33282 36
  • 24 (a)
ManyToMany
CG4607 36
  • 22 (a)
ManyToMany
CG4797 36
  • 22 (a)
ManyToMany
CG6484 36
  • 34 (a)
ManyToMany
CG8249 36
  • 24 (a)
ManyToMany
CG8837 36
  • 19 (a)
ManyToMany
Glut3 36
  • 20 (a)
ManyToMany
sut4 36
  • 32 (a)
ManyToMany
Tret1-1 36
  • 19 (a)
ManyToMany
Tret1-2 35
  • 49.09 (n)
  • 40.14 (a)
Tret1-2 36
  • 35 (a)
ManyToMany
CG1213 37
  • 32 (a)
CG10960 37
  • 36 (a)
CG8234 37
  • 38 (a)
sut4 37
  • 32 (a)
CG4797 37
  • 26 (a)
CG6484 37
  • 34 (a)
CG8249 37
  • 28 (a)
CG15408 37
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL2 36
  • 21 (a)
ManyToMany
HXT1 36
  • 22 (a)
ManyToMany
HXT10 36
  • 24 (a)
ManyToMany
HXT11 36
  • 21 (a)
ManyToMany
HXT13 36
  • 21 (a)
ManyToMany
HXT14 36
  • 18 (a)
ManyToMany
HXT15 36
  • 21 (a)
ManyToMany
HXT16 36
  • 21 (a)
ManyToMany
HXT17 36
  • 21 (a)
ManyToMany
HXT2 36
  • 24 (a)
ManyToMany
HXT3 36
  • 22 (a)
ManyToMany
HXT4 36
  • 22 (a)
ManyToMany
HXT5 36
  • 22 (a)
ManyToMany
HXT6 36
  • 22 (a)
ManyToMany
HXT7 36
  • 22 (a)
ManyToMany
HXT8 36
  • 21 (a)
ManyToMany
HXT9 36
  • 21 (a)
ManyToMany
RGT2 36
  • 15 (a)
ManyToMany
SNF3 36
  • 13 (a)
ManyToMany
STL1 36
  • 20 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75220 35
  • 45.29 (n)
  • 40.62 (a)
rice
(Oryza sativa)
Liliopsida Os05g0579000 35
  • 49.04 (n)
  • 39.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 38 (a)
ManyToMany
CSA.10291 36
  • 36 (a)
ManyToMany
Species with no ortholog for SLC2A8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A8 Gene

ENSEMBL:
Gene Tree for SLC2A8 (if available)
TreeFam:
Gene Tree for SLC2A8 (if available)

Paralogs for SLC2A8 Gene

Paralogs for SLC2A8 Gene

genes like me logo Genes that share paralogs with SLC2A8: view

Variants for SLC2A8 Gene

Sequence variations from dbSNP and Humsavar for SLC2A8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs6635 -- 127,407,595(+) CATTC(A/G)GTCGC utr-variant-3-prime, nc-transcript-variant
rs1138739 -- 127,402,714(+) GGCTC(C/T)GAGCA reference, synonymous-codon, intron-variant
rs1138740 -- 127,403,716(+) ATCGG(C/T)GTCTC reference, synonymous-codon, nc-transcript-variant
rs3088163 -- 127,407,721(-) AGTGA(A/T)GGGAA utr-variant-3-prime, nc-transcript-variant, downstream-variant-500B
rs3802363 -- 127,405,290(-) GTCCC(A/G)CCAGC intron-variant

Relevant External Links for SLC2A8 Gene

HapMap Linkage Disequilibrium report
SLC2A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SLC2A8 Gene

Disorders for SLC2A8 Gene

Relevant External Links for SLC2A8

Human Genome Epidemiology (HuGE) Navigator
SLC2A8
genes like me logo Genes that share disorders with SLC2A8: view

No data available for UniProtKB/Swiss-Prot for SLC2A8 Gene

Publications for SLC2A8 Gene

  1. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (PMID: 10821868) Doege H. … Joost H.-G. (J. Biol. Chem. 2000) 2 3 4 23
  2. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (PMID: 10671487) Ibberson M.R. … Thorens B. (J. Biol. Chem. 2000) 2 3 4
  3. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. (PMID: 11845330) SchA1rmann A. … Joost H.G. (Cell Tissue Res. 2002) 3 23
  4. Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy. (PMID: 12915684) von Wolff M. … Strowitzki T. (J. Clin. Endocrinol. Metab. 2003) 23
  5. Expression and regulation of glucose transporter 8 in rat Leydig cells. (PMID: 14529566) Chen Y. … Lin T. (J. Endocrinol. 2003) 23

Products for SLC2A8 Gene

Sources for SLC2A8 Gene

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