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SLC2A8 Gene

protein-coding   GIFtS: 53
GCID: GC09P130159

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

(Previous name: solute carrier family 2 (facilitated glucose transporter)...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 81 2     GLUTX12 3
GLUT82 3 5     Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 81
Glucose Transporter Type 82 3     Solute Carrier Family 2, Facilitated Glucose Transporter Member 82
Glucose Transporter Type X12 3     GLUT-83

External Ids:    HGNC: 138121   Entrez Gene: 299882   Ensembl: ENSG000001368567   OMIM: 6052455   UniProtKB: Q9NY643   

Export aliases for SLC2A8 gene to outside databases

Previous GC identifers: GC09P121274 GC09P121806 GC09P123613 GC09P125535 GC09P127239 GC09P129199 GC09P099775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A8 Gene:
This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on
sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class
II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12
transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane.
Alternatively spliced transcript variants have been described for this gene. (provided by RefSeq, Nov 2012)

GeneCards Summary for SLC2A8 Gene:
SLC2A8 (solute carrier family 2 (facilitated glucose transporter), member 8) is a protein-coding gene. GO annotations related to this gene include glucose transmembrane transporter activity and glucose binding. An important paralog of this gene is SLC2A6.

UniProtKB/Swiss-Prot: GTR8_HUMAN, Q9NY64
Function: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable
manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A8 gene promoter:
         RP58   AP-1   HTF   NRSF form 1   MyoD   FOXD1   NRSF form 2   RORalpha1   AREB6   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A8 promoter sequence
   Search Chromatin IP Primers for SLC2A8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3

SLC2A8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A8 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P130159:  view genomic region     (about GC identifiers)

Start:
130,159,421 bp from pter      End:
130,170,703 bp from pter
Size:
11,283 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GTR8_HUMAN, Q9NY64 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 8  
Size: 477 amino acids; 50819 Da
Subunit: Interacts with AP2B1 (By similarity)
Secondary accessions: Q8WUZ9 Q9NSC4

Explore the universe of human proteins at neXtProt for SLC2A8: NX_Q9NY64

Explore proteomics data for SLC2A8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys465
  • Glycosylation2 at Asn349
  • Modification sites at PhosphoSitePlus

  • See SLC2A8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001258640.1  NP_001258641.1  NP_055395.2  

    ENSEMBL proteins: 
     ENSP00000362469   ENSP00000392434   ENSP00000411726   ENSP00000362450   ENSP00000362458  
     ENSP00000413973   ENSP00000404893   ENSP00000389070   ENSP00000391213  
    Reactome Protein details: Q9NY64

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 8
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9NY64

    ProtoNet protein and cluster: Q9NY64

    3 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR8_HUMAN, Q9NY64
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR8_HUMAN, Q9NY64
    Function: Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable
    manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity)
    Induction: In testis, down-regulated by estrogen

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0005536glucose binding IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC2A8           About GenesLikeMe


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc2a8):
     cardiovascular system  digestive/alimentary  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  reproductive system 

    Find genes that share phenotypes with SLC2A8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for SLC2A8: Slc2a8tm1.1Thor Slc2a8tm1.1Asch Slc2a8tm1Khm

       genOway: Develop your customized and physiologically relevant rodent model for SLC2A8

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR8_HUMAN, Q9NY64: Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasmic vesicle membrane;
    Multi-pass membrane protein (By similarity). Note=Principally intracellular. May move between intracellular
    vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005765lysosomal membrane IDA17897319
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with SLC2A8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A8 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Facilitative Na+-independent glucose transporters0.00


    Find genes that share SuperPaths with SLC2A8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for SLC2A8
        Facilitative Na+-independent glucose transporters


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A8
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for SLC2A8 (Q9NY643 ENSP000003624694) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LAMP1P112793, ENSP000003332984I2D: score=1 STRING: ENSP00000333298
    LAMP2P134733, ENSP000004084114I2D: score=1 STRING: ENSP00000408411
    AP1G1O437473, ENSP000003771484I2D: score=1 STRING: ENSP00000377148
    AP2B1P630103, ENSP000003144144I2D: score=1 STRING: ENSP00000314414
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0005975carbohydrate metabolic process TAS10671487
    GO:0007141male meiosis I IEA--
    GO:0008286insulin receptor signaling pathway IEA--
    GO:0008643carbohydrate transport ----

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for SLC2A8 (GTR8)

    1 Novoseek inferred chemical compound relationship for SLC2A8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 43 23 10821868 (4), 11689004 (3), 15488990 (3), 11845330 (2) (see all 7)



    Find genes that share compounds with SLC2A8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC2A8 gene (3 alternative transcripts): 
    NM_001271711.1  NM_001271712.1  NM_014580.4  

    Unigene Cluster for SLC2A8:

    Solute carrier family 2 (facilitated glucose transporter), member 8
    Hs.179522  [show with all ESTs]
    Unigene Representative Sequence: NM_014580
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373371(uc004bqu.3 uc010mxj.3) ENST00000451404 ENST00000419917
    ENST00000373352 ENST00000373360 ENST00000419132 ENST00000439597 ENST00000423934
    ENST00000430147 ENST00000484617 ENST00000489239 ENST00000477027 ENST00000485806
    ENST00000484208
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    Additional mRNA sequence: 

    AF289587.1 AJ245937.1 BC019043.2 NR_073416.1 Y17801.1 

    15 DOTS entries:

    DT.95276690  DT.113798  DT.92424096  DT.105642  DT.97819608  DT.95276688  DT.121163316  DT.100773111 
    DT.75159838  DT.95276682  DT.95276684  DT.40248217  DT.95276687  DT.100676293  DT.92424094 

    Selected AceView cDNA sequences (see all 117):

    BE261639 BF732259 CR625717 BI831086 AW248655 BM545247 BI334832 AI818661 
    CA423844 CA306503 BF940419 BI752171 CB218134 BQ919165 AI628848 AL534131 
    BU626294 BQ011294 AI094911 AI971919 NM_014580 BC019043 BQ773697 BU684780 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A8 (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
    SP1:                                -           -     -                 -                                                               
    SP2:                          -     -     -     -     -           -     -                                                               
    SP3:                          -     -     -     -     -                 -                                                               
    SP4:                                                                    -     -                                                         
    SP5:                                                                    -                                                               


    ECgene alternative splicing isoforms for SLC2A8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC2A8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCAAGACTA
    SLC2A8 Expression
    About this image

    SLC2A8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.179522

    UniProtKB/Swiss-Prot: GTR8_HUMAN, Q9NY64
    Tissue specificity: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most
    other tissues

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC2A8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a81 , 5 solute carrier family 2, (facilitated glucose transporter), more1, 5 85.5(n)1
    86.55(a)1
      2 (22.09 cM)5
    560171  NM_019488.41  NP_062361.11 
     329729905 
    chicken
    (Gallus gallus)
    Aves SLC2A81 solute carrier family 2 (facilitated glucose transporter), more 60.34(n)
    60.13(a)
      378802  NM_204375.1  NP_989706.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A86
    solute carrier family 2 (facilitated glucose trans...
    54(a)
    1 ↔ 1
    GL344796.1(2909-19090)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004869431 solute carrier family 2, facilitated glucose transporter more 65.5(n)
    64.41(a)
      100486943  XM_002935222.2  XP_002935268.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.174292 Danio rerio cDNA clone MGC56364 IMAGE5604396, complete more 74.87(n)    BC049409.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82343
    Tret1-21
    fructose transporter3
    Trehalose transporter 1-21
    38(a)
    (best of 8)3
    49.09(n)1
    40.14(a)1
      362491  NM_136850.31  NP_610694.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HXT106
    HXT26
    (see all 20)
    Putative hexose transporter, expressed at low leve...
    High-affinity glucose transporter of the major fac...
    (see all 20)
    24(a)
    24(a)
    (see all 20)
    many ↔ many
    many ↔ many
    (see all 20)
    VI(112345-113985) YFL011W
    XIII(288079-289704) YMR011W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G752201 AT1G75220 45.29(n)
    40.62(a)
      843859  NM_106178.3  NP_177658.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g05790001 Os05g0579000 49.04(n)
    39.95(a)
      4339710  NM_001062951.1  NP_001056416.1 


    ENSEMBL Gene Tree for SLC2A8 (if available)
    TreeFam Gene Tree for SLC2A8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A8 gene
    SLC2A62  
    4 SIMAP similar genes for SLC2A8 using alignment to 10 protein entries:     GTR8_HUMAN (see all proteins):
    SLC2A10    SLC2A6    SLC2A2    SLC2A1

    Find genes that share paralogs with SLC2A8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SLC2A8 (see all 322)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1852854181,2
    --130157521(+) CCCCAC/TGTCTG 4 -- us2k10--------
    rs1164780881,2
    C,F--130157530(+) TGCCAT/CGCAGA 4 -- us2k11Minor allele frequency- C:0.06WA 118
    rs1912275221,2
    --130157549(+) CAGTGC/TCTTGT 4 -- us2k10--------
    rs38088401,2
    C,H--130157727(-) AATTGT/CGGGTG 4 -- us2k16Minor allele frequency- C:0.00NS EA NA 422
    rs38088391,2
    C,F,H--130157777(-) TCCACC/GTCTTG 4 -- us2k119Minor allele frequency- G:0.17EA NS NA WA 3370
    rs1162609391,2
    F--130157906(+) CCATCG/AGCCAC 4 -- us2k11Minor allele frequency- A:0.03WA 118
    rs38088381,2
    C,F,A,H--130157934(-) GATTAT/CGTAGG 4 -- us2k124Minor allele frequency- C:0.24EA NS NA 3854
    rs1836408161,2
    --130158069(+) TCCATA/TGGGGG 4 -- us2k10--------
    rs1886864961,2
    --130158081(+) AGGACA/GGAAGT 4 -- us2k10--------
    rs1928310121,2
    --130158122(+) CTGTGA/GTAAGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC2A8 (130159421 - 130170703 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for SLC2A8: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A8
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605245    OMIM disorders: --


    Find genes that share disorders with SLC2A8           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: SLC2A8 (1 document)

    Export disorders for SLC2A8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC2A8 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with SLC2A8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (PubMed id 10821868)1, 2, 3, 9 Doege H.... Joost H.-G. (J. Biol. Chem. 2000)
    2. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (PubMed id 10671487)1, 2, 3 Ibberson M.R.... Thorens B. (J. Biol. Chem. 2000)
    3. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. (PubMed id 11845330)1, 9 SchA1rmann A....Joost H.G. (Cell Tissue Res. 2002)
    4. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. (PubMed id 23234877)1 Chong M.S....Lee T.S. (J. Alzheimers Dis. 2013)
    5. Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid. (PubMed id 23319000)1 Luykx J.J....Ophoff R.A. (Mol. Psychiatry 2013)
    6. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. (PubMed id 22452979)1 McBrayer S.K....Shanmugam M. (Blood 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). (PubMed id 20965718)1 Campa D....Canzian F. (Eur. J. Cancer 2011)
    10. GLUT8, the enigmatic intracellular hexose transporter. (PubMed id 19176349)1 Schmidt S....SchA1rmann A. (Am. J. Physiol. Endocrinol. Metab. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29988 HGNC: 13812 AceView: SLC2A8 Ensembl:ENSG00000136856 euGenes: HUgn29988
    ECgene: SLC2A8 H-InvDB: SLC2A8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for SLC2A8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for SLC2A8 gene:
    Search GeneIP for patents involving SLC2A8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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