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Aliases for SLC2A8 Gene

Aliases for SLC2A8 Gene

  • Solute Carrier Family 2 Member 8 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 8 2 3
  • Glucose Transporter Type X1 3 4
  • Glucose Transporter Type 8 3 4
  • GLUTX1 3 4
  • GLUT8 3 4
  • Solute Carrier Family 2 (Facilitated Glucose Transporter) Member 8 2
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 8 3
  • GLUT-8 4

External Ids for SLC2A8 Gene

Previous GeneCards Identifiers for SLC2A8 Gene

  • GC09P121274
  • GC09P121806
  • GC09P123613
  • GC09P125535
  • GC09P127239
  • GC09P129199
  • GC09P130159
  • GC09P099775

Summaries for SLC2A8 Gene

Entrez Gene Summary for SLC2A8 Gene

  • This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

GeneCards Summary for SLC2A8 Gene

SLC2A8 (Solute Carrier Family 2 Member 8) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Clathrin-mediated endocytosis. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A6.

UniProtKB/Swiss-Prot for SLC2A8 Gene

  • Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).

Additional gene information for SLC2A8 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A8 Gene

Genomics for SLC2A8 Gene

Regulatory Elements for SLC2A8 Gene

Enhancers for SLC2A8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H127516 1.7 FANTOM5 Ensembl ENCODE dbSUPER 16.9 +124.4 124369 9.3 PKNOX1 ARNT RAD21 CHAMP1 RFX5 GTF3C2 ZNF766 CBX5 ZNF143 FOS RPL12 SLC2A8 ZNF79 SNORA65 GLE1 NAIF1 GOLGA2 CIZ1 URM1 FAM129B
GH09H127420 1.1 ENCODE 22.6 +26.0 26047 4.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 ZNF143 RPL12 SLC2A8 ENSG00000272696 CDK9 NAIF1 SNORA65 PTRH1 GC09M127421 PIR59639
GH09H127502 1.3 ENCODE dbSUPER 16.3 +109.5 109452 7.7 PKNOX1 ARID4B ZNF2 TCF12 ZNF121 ZNF766 GLIS2 GATA2 ZNF143 FOS RPL12 SLC2A8 LRSAM1 LOC105376281 ENSG00000200788
GH09H127800 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +405.6 405551 4.5 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 ENG SLC2A8 FPGS LOC102723566 ENSG00000227218 URM1 FAM129B CDK9 TOR2A SH2D3C
GH09H127392 1.3 ENCODE dbSUPER 15.7 -1.4 -1404 7.1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF79 SLC2A8 NAIF1 ENSG00000228487 GARNL3 SNORA65 CIZ1 RPL12 ENSG00000271833 TOR2A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC2A8 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241684 162 1801 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A YY1 ZNF143 ZNF207 FOS

Genomic Locations for SLC2A8 Gene

Genomic Locations for SLC2A8 Gene
chr9:127,397,138-127,408,424
(GRCh38/hg38)
Size:
11,287 bases
Orientation:
Plus strand
chr9:130,159,421-130,170,703
(GRCh37/hg19)

Genomic View for SLC2A8 Gene

Genes around SLC2A8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A8 Gene

Proteins for SLC2A8 Gene

  • Protein details for SLC2A8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY64-GTR8_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 8
    Protein Accession:
    Q9NY64
    Secondary Accessions:
    • Q8WUZ9
    • Q9NSC4

    Protein attributes for SLC2A8 Gene

    Size:
    477 amino acids
    Molecular mass:
    50819 Da
    Quaternary structure:
    • Interacts with AP2B1.

neXtProt entry for SLC2A8 Gene

Post-translational modifications for SLC2A8 Gene

  • Ubiquitination at isoforms=465
  • Glycosylation at Asn349
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A8 Gene

Domains & Families for SLC2A8 Gene

Gene Families for SLC2A8 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q9NY64

UniProtKB/Swiss-Prot:

GTR8_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A8: view

Function for SLC2A8 Gene

Molecular function for SLC2A8 Gene

UniProtKB/Swiss-Prot Function:
Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity).
UniProtKB/Swiss-Prot Induction:
In testis, down-regulated by estrogen.

Phenotypes From GWAS Catalog for SLC2A8 Gene

Gene Ontology (GO) - Molecular Function for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity TAS 10671487
GO:0005536 glucose binding IEA --
GO:0022857 transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A8: view
genes like me logo Genes that share phenotypes with SLC2A8: view

Animal Models for SLC2A8 Gene

MGI Knock Outs for SLC2A8:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A8 Gene

Localization for SLC2A8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A8 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A8 gene
Compartment Confidence
plasma membrane 5
lysosome 5
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA,TAS --
GO:0008021 synaptic vesicle IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A8: view

Pathways & Interactions for SLC2A8 Gene

genes like me logo Genes that share pathways with SLC2A8: view

Gene Ontology (GO) - Biological Process for SLC2A8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS 10671487
GO:0006810 transport IEA --
GO:0007141 male meiosis I IEA --
GO:0008286 insulin receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with SLC2A8: view

No data available for SIGNOR curated interactions for SLC2A8 Gene

Drugs & Compounds for SLC2A8 Gene

(2) Drugs for SLC2A8 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved Pharma Transporter, substrate 0
genes like me logo Genes that share compounds with SLC2A8: view

Transcripts for SLC2A8 Gene

Unigene Clusters for SLC2A8 Gene

Solute carrier family 2 (facilitated glucose transporter), member 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - -
SP5: -
SP6: - -
SP7: - -
SP8: - - - -
SP9:
SP10:

Relevant External Links for SLC2A8 Gene

GeneLoc Exon Structure for
SLC2A8
ECgene alternative splicing isoforms for
SLC2A8

Expression for SLC2A8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A8 Gene

Protein differential expression in normal tissues from HIPED for SLC2A8 Gene

This gene is overexpressed in Nasal epithelium (67.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A8 Gene



Protein tissue co-expression partners for SLC2A8 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A8 Gene:

SLC2A8

SOURCE GeneReport for Unigene cluster for SLC2A8 Gene:

Hs.179522

mRNA Expression by UniProt/SwissProt for SLC2A8 Gene:

Q9NY64-GTR8_HUMAN
Tissue specificity: Highly expressed in testis, but not in testicular carcinoma. Lower amounts present in most other tissues.

Evidence on tissue expression from TISSUES for SLC2A8 Gene

  • Skin(4.2)
  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with SLC2A8: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A8 Gene

Orthologs for SLC2A8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A8 33 34
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia SLC2A8 33 34
  • 88.19 (n)
dog
(Canis familiaris)
Mammalia SLC2A8 33 34
  • 88.12 (n)
mouse
(Mus musculus)
Mammalia Slc2a8 33 16 34
  • 85.5 (n)
rat
(Rattus norvegicus)
Mammalia Slc2a8 33
  • 85.46 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A8 34
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A8 34
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A8 33 34
  • 60.34 (n)
lizard
(Anolis carolinensis)
Reptilia SLC2A8 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486943 33
  • 65.5 (n)
zebrafish
(Danio rerio)
Actinopterygii slc2a8 33 34
  • 61.35 (n)
Dr.17429 33
fruit fly
(Drosophila melanogaster)
Insecta Tret1-2 33 34
  • 49.09 (n)
CG8234 35
  • 38 (a)
CG10960 35 34
  • 36 (a)
CG6484 35 34
  • 34 (a)
CG1213 35 34
  • 32 (a)
sut4 35 34
  • 32 (a)
CG1208 34
  • 31 (a)
ManyToMany
CG8249 35 34
  • 28 (a)
CG33281 34
  • 27 (a)
ManyToMany
CG4797 35 34
  • 26 (a)
CG15406 34
  • 26 (a)
ManyToMany
CG15408 35 34
  • 25 (a)
CG3285 34
  • 25 (a)
ManyToMany
CG14606 34
  • 24 (a)
ManyToMany
CG33282 34
  • 24 (a)
ManyToMany
CG14605 34
  • 23 (a)
ManyToMany
CG4607 34
  • 22 (a)
ManyToMany
Glut3 34
  • 20 (a)
ManyToMany
CG8837 34
  • 19 (a)
ManyToMany
Tret1-1 34
  • 19 (a)
ManyToMany
CG31100 34
  • 15 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HXT10 34
  • 24 (a)
ManyToMany
HXT2 34
  • 24 (a)
ManyToMany
HXT1 34
  • 22 (a)
ManyToMany
HXT3 34
  • 22 (a)
ManyToMany
HXT4 34
  • 22 (a)
ManyToMany
HXT5 34
  • 22 (a)
ManyToMany
HXT6 34
  • 22 (a)
ManyToMany
HXT7 34
  • 22 (a)
ManyToMany
GAL2 34
  • 21 (a)
ManyToMany
HXT11 34
  • 21 (a)
ManyToMany
HXT13 34
  • 21 (a)
ManyToMany
HXT15 34
  • 21 (a)
ManyToMany
HXT16 34
  • 21 (a)
ManyToMany
HXT17 34
  • 21 (a)
ManyToMany
HXT8 34
  • 21 (a)
ManyToMany
HXT9 34
  • 21 (a)
ManyToMany
STL1 34
  • 20 (a)
ManyToMany
HXT14 34
  • 18 (a)
ManyToMany
RGT2 34
  • 15 (a)
ManyToMany
SNF3 34
  • 13 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G75220 33
  • 45.29 (n)
rice
(Oryza sativa)
Liliopsida Os05g0579000 33
  • 49.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 38 (a)
ManyToMany
CSA.10291 34
  • 36 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
Species where no ortholog for SLC2A8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A8 Gene

ENSEMBL:
Gene Tree for SLC2A8 (if available)
TreeFam:
Gene Tree for SLC2A8 (if available)

Paralogs for SLC2A8 Gene

Paralogs for SLC2A8 Gene

genes like me logo Genes that share paralogs with SLC2A8: view

Variants for SLC2A8 Gene

Sequence variations from dbSNP and Humsavar for SLC2A8 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000251139 -- 127,399,945(+) CGGGG(A/G)TTGCT nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000253482 -- 127,396,508(+) CAGGG(C/T)CACGC upstream-variant-2KB
rs1000553168 -- 127,401,183(+) TGGCC(A/G)AGTCA intron-variant
rs1000601314 -- 127,405,914(+) CCTTG(C/T)TGTGT intron-variant
rs1000823450 -- 127,406,166(+) CTGGC(A/C)TGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A8 Gene

Variant ID Type Subtype PubMed ID
nsv615343 CNV loss 21841781

Variation tolerance for SLC2A8 Gene

Residual Variation Intolerance Score: 75.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A8 Gene

Disorders for SLC2A8 Gene

Relevant External Links for SLC2A8

Human Genome Epidemiology (HuGE) Navigator
SLC2A8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A8

No disorders were found for SLC2A8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A8 Gene

Publications for SLC2A8 Gene

  1. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. (PMID: 10821868) Doege H … Joost HG (The Journal of biological chemistry 2000) 2 3 4 22 60
  2. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. (PMID: 10671487) Ibberson M … Thorens B (The Journal of biological chemistry 2000) 2 3 4 60
  3. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. (PMID: 11845330) Schürmann A … Joost HG (Cell and tissue research 2002) 3 22 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains. (PMID: 27818355) Mashima M … Ueno M (Neuroscience letters 2017) 3 60

Products for SLC2A8 Gene

Sources for SLC2A8 Gene

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