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SLC2A7 Gene

protein-coding   GIFtS: 46
GCID: GC01M009063

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 71 2
GLUT72 3 5
Intestinal Facilitative Glucose Transporter 71 2
Glucose Transporter Type 72 3
GLUT-72 3
Solute Carrier Family 2, Facilitated Glucose Transporter Member 72

External Ids:    HGNC: 134451   Entrez Gene: 1551842   Ensembl: ENSG000001972417   OMIM: 6103715   UniProtKB: Q6PXP33   

Export aliases for SLC2A7 gene to outside databases

Previous GC identifers: GC01U990466 GC01M008998 GC01M008985 GC01M008213


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A7 Gene:
SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et
al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally
significant amino acid residues (Joost and Thorens, 2001 (PubMed 11780753)).(supplied by OMIM, Mar 2008)

GeneCards Summary for SLC2A7 Gene:
SLC2A7 (solute carrier family 2 (facilitated glucose transporter), member 7) is a protein-coding gene. GO annotations related to this gene include substrate-specific transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3
Function: High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and
xylose

Gene Wiki entry for SLC2A7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A7 gene promoter:
         RP58   NF-1   NF-1/L   p53   AP-4   YY1   E47   GATA-6   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A7 promoter sequence
   Search Chromatin IP Primers for SLC2A7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

SLC2A7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A7 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M009063:  view genomic region     (about GC identifiers)

Start:
9,063,359 bp from pter      End:
9,086,404 bp from pter
Size:
23,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 7  
Size: 512 amino acids; 55728 Da
1 PDB 3D structure from and Proteopedia for SLC2A7:
1YG7 (3D)    
Secondary accessions: A2A333

Explore the universe of human proteins at neXtProt for SLC2A7: NX_Q6PXP3

Explore proteomics data for SLC2A7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57

  • See SLC2A7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997303.2  
    ENSEMBL proteins: 
     ENSP00000383698  
    Reactome Protein details: Q6PXP3

    SLC2A7 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 7
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q6PXP3

    ProtoNet protein and cluster: Q6PXP3

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002442 Fructose transporter (GLUT5) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR7_HUMAN, Q6PXP3
    Function: High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and
    xylose

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC2A7           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR7_HUMAN, Q6PXP3: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC2A7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A7 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Facilitative Na+-independent glucose transporters0.00
    Transmembrane transport of small molecules0.47
    Class II GLUTs0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2HIF1Alpha Pathway
    HIF1Alpha Pathway


    Find genes that share SuperPaths with SLC2A7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for SLC2A7
        HIF1Alpha Pathway

    1 Reactome Pathway for SLC2A7
        Class II GLUTs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A7
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A7

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008643carbohydrate transport IEA--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC2A7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A7 (GTR7)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC2A7 gene: 
    NM_207420.2  

    Unigene Cluster for SLC2A7:

    Solute carrier family 2 (facilitated glucose transporter), member 7
    Hs.531239
    Unigene Representative Sequence: AY571960
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000400906(uc009vmo.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat SLC2A7

    Additional mRNA sequence: AY571960.2 

    1 DOTS entry:

    DT.102820012 

    3 AceView cDNA sequences:

    AY571960 NM_207420 CD357249 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC2A7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGACGGGG
    SLC2A7 Expression
    About this image

    SLC2A7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.531239

    UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3
    Tissue specificity: Expressed in small intestine and colon. Weakly expressed in testis and prostate

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC2A7 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a71 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 78.15(n)1
    76.13(a)1
      4 (81.04 cM)5
    4358181  NM_001085529.11  NP_001078998.11 
     1501489725 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    39(a)
    many ↔ many
    6(22366965-22370795)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    43(a)
    40(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    GL344358.1(22867-32636)
    GL344358.1(3131-17477)
    zebrafish
    (Danio rerio)
    Actinopterygii slc2a11a6
    slc2a15b6
    solute carrier family 2 (facilitated glucose trans...
    solute carrier family 2 (facilitated glucose trans...
    40(a)
    39(a)
    many ↔ many
    many ↔ many
    6(40906519-40921337) ENSDARG00000053961
    1(31027197-31052389) ENSDARG00000053269


    ENSEMBL Gene Tree for SLC2A7 (if available)
    TreeFam Gene Tree for SLC2A7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A7 gene
    ENSG000002513572  SLC2A52  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    11 SIMAP similar genes for SLC2A7 using alignment to 1 protein entry:     GTR7_HUMAN:
    SLC2A5    SLC2A9    SLC2A1    SLC2A4    SLC2A11-a    SLC2A11-c
    SLC2A11    SLC2A3    SLC2A10    SLC2A14    SLC2A2

    Find genes that share paralogs with SLC2A7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC2A7 (see all 709)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896757231,2
    --9062874(+) CCTGTC/GATCGA 1 -- ds50010--------
    rs1471944361,2
    C--9062897(+) GGGCAC/TGCAGG 1 -- ds50010--------
    rs127279061,2
    C,F,H--9062932(+) GCCACG/AGGGTG 1 -- ds500110Minor allele frequency- A:0.04NS EA NA CSA 666
    rs173899481,2
    C,F,H--9062952(+) AGCCAC/TGTCGC 1 -- ds500128Minor allele frequency- T:0.14NA EA NS CSA WA 2979
    rs3707540651,2
    C--9062956(+) ACGTCA/GCAGGA 1 -- ds50010--------
    rs604240801,2
    C,F--9063005(+) TGCAAT/CGACGG 1 -- ds50014Minor allele frequency- C:0.24WA NA 124
    rs1388023661,2
    C--9063021(+) CGGGTA/GTCCAT 1 -- ds50010--------
    rs558577301,2
    C,F--9063053(+) GTTTTA/GCTTTA 1 -- ds50013Minor allele frequency- G:0.26WA 122
    rs1429128631,2
    --9063082(+) TCATTC/TAAATT 1 -- ds50010--------
    rs341113591,2
    C,F--9063103(+) TGTAGA/GATCGG 1 -- ds50018Minor allele frequency- G:0.08NA CSA WA EA 368

    HapMap Linkage Disequilibrium report for SLC2A7 (9063359 - 9086404 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC2A7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv871609CNV Loss21882294
    nsv462727CNV Loss19166990
    nsv525092CNV Gain19592680
    nsv462616CNV Gain19166990
    nsv871694CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610371    OMIM disorders: --


    Find genes that share disorders with SLC2A7           About GenesLikeMe


    Export disorders for SLC2A7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC2A7 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with SLC2A7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. (PubMed id 15033637)1, 2, 9 Li Q.... Cheeseman C.I. (Am. J. Physiol. 2004)
    2. The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). (PubMed id 11780753)1, 3, 9 Joost H.G. and Thorens B. (Mol. Membr. Biol. 2001)
    3. Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). (PubMed id 16186102)1, 9 Manolescu A....Cheeseman C.I. (J. Biol. Chem. 2005)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Insight into the &quot;odd&quot; hexose transporters GLUT3, GLUT5, and GLUT7. (PubMed id 18460594)9 SchA1rmann A. (Am. J. Physiol. Endocrinol. Metab. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 155184 HGNC: 13445 AceView: SLC2A7 Ensembl:ENSG00000197241 euGenes: HUgn155184
    ECgene: SLC2A7 H-InvDB: SLC2A7

    (According to HUGE)
    About This Section

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A7 gene:
    Search GeneIP for patents involving SLC2A7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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