SLC2A7 Gene
protein-coding GIFtS: 44
GCID: GC01M009063
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solute carrier family 2 (facilitated glucose transporter),...
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Aliases
for SLC2A7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 71 2 | | GLUT71 2 3 5 | | Glucose Transporter Type 72 3 | | GLUT-72 3 | | Intestinal Facilitative Glucose Transporter 72 | | Solute Carrier Family 2, Facilitated Glucose Transporter Member 72 |
Export aliases for SLC2A7 gene to outside databasesPrevious GC identifers: GC01U990466 GC01M008998 GC01M008985 GC01M008213 |
Summaries
for SLC2A7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for SLC2A7:
SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al.,2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significantamino acid residues (Joost and Thorens, 2001 (PubMed 11780753)).(supplied by OMIM, Mar 2008)
UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3Function: High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose
Gene Wiki entry for SLC2A7
|
Genomic Views
for SLC2A7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the SLC2A7 gene promoter:
RP58 NF-1 NF-1/L p53 AP-4 YY1 E47 GATA-6 Pax-4a ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for SLC2A7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.2 Ensembl cytogenetic band: 1p36.23 HGNC cytogenetic band: 1p36.2SLC2A7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M009063: view genomic region
(about GC identifiers)
Start:
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9,063,359 bp from pter |
End:
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9,086,404 bp from pter |
Size:
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23,046 bases |
Orientation:
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minus strand |
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Proteins
for SLC2A7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3 (See
protein sequence)Recommended Name: Solute carrier family 2, facilitated glucose transporter member 7 Size: 512 amino acids; 55728 Da
Subcellular location: Membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for SLC2A7:1YG7 (3D)
Secondary accessions: A2A333Explore the universe of human proteins at neXtProt for SLC2A7: NX_Q6PXP3
SLC2A7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_997303.2
ENSEMBL proteins: ENSP00000383698 Reactome Protein details: Q6PXP3
Human Recombinant Protein Products for SLC2A7:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
SLC2A7 for ontologies About GeneDecksing
SLC2A7 Antibody Products:
Assay Products for SLC2A7: |
Protein
Domains /
Families
for SLC2A7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
SLC2A7 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6PXP3ProtoNet protein and cluster: Q6PXP3 4 Blocks protein families: IPB000803 Mammalian facilitated glucose transporter family signature IPB002442 Fructose transporter (GLUT5) signature IPB003663 Sugar transporter signature IPB005829 Sugar transporter superfamily
UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transportersubfamily |
Function
for SLC2A7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: GTR7_HUMAN, Q6PXP3Function: High-affinity transporter for glucose and fructose Does not transport galactose, 2-deoxy-d-glucose and xylose Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0022891 | substrate-specific transmembrane transporter activity |
IEA | -- |
SLC2A7 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC2A7
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A7 |
|
Pathways & Interactions
for SLC2A7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | SLC-mediated transmembrane transport | | | 2 | Facilitative Na+-independent glucose transporters | | | 3 | HIF1Alpha Pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for SLC2A7
5 
Reactome Pathways for SLC2A7
SLC2A7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A7
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008643 | carbohydrate transport |
IEA | -- | | GO:0055085 | transmembrane transport |
TAS | -- |
SLC2A7 for ontologies About GeneDecksing
|
Drugs & Compounds
for SLC2A7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for SLC2A7
Search CenterWatch for drugs/clinical trials and news about SLC2A7 / GTR7
|
Transcripts
for SLC2A7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for SLC2A7 gene: NM_207420.2 Unigene Cluster for SLC2A7: Solute carrier family 2 (facilitated glucose transporter), member 7 Hs.531239 Unigene Representative Sequence: AY5719601 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000400906(uc009vmo.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC2A7 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC2A7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: SLC2A7 (NM_207420) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for SLC2A7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A7 |
Additional cDNA sequence: AY571960.2 1 DOTS entry: DT.102820012 3 AceView cDNA sequences: AY571960 NM_207420 CD357249
GeneLoc Exon Structure
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Expression
for SLC2A7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| SLC2A7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGACGGGG
About this image
See SLC2A7 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.531239
UniProtKB/Swiss-Prot: GTR7_HUMAN, Q6PXP3Tissue specificity: Expressed in small intestine and colon. Weakly expressed in testis and prostate
SABiosciences Custom PCR Arrays for SLC2A7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC2A7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat SLC2A7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC2A7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC2A7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A7 |
Orthologs
for SLC2A7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for SLC2A7 gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for SLC2A7 (if available)
TreeFam Gene Tree for SLC2A7 (if available) |
Paralogs
for SLC2A7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for SLC2A7 gene
- ENSG000002513572 SLC2A52 SLC2A32 SLC2A92 SLC2A142 SLC2A22 SLC2A12 SLC2A42
- SLC2A112
12 SIMAP similar genes for SLC2A7 using alignment to 1 protein entry: GTR7_HUMAN:SLC2A5 SLC2A9 SLC2A1 SLC2A4 SLC2A11-a SLC2A11-c
SLC2A11 SLC2A3 SLC2A10 SLC2A14 SLC2A2 SLC2A8
SLC2A7 for paralogs About GeneDecksing
|
Genomic Variants
for SLC2A7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for SLC2A7 (9063359 - 9086404 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for SLC2A7: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for SLC2A7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
SLC2A7 for disorders About GeneDecksing
OMIM gene information: 610371
OMIM disorders: --
1  disease for SLC2A7: About MalaCardsprostatitis
Export disorders for SLC2A7 gene to outside databases
|
Publications
for SLC2A7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for SLC2A7 gene integrated from 9 sources:
(articles sorted by number of sources associating them with SLC2A7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. (PubMed id 15033637)1, 2, 9 Li Q.... Cheeseman C.I. (2004)
- The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review). (PubMed id 11780753)1, 3, 9 Joost H.G. and Thorens B. (2001)
- Identification of a hydrophobic residue as a key determinant of fructose transport by the facilitative hexose transporter SLC2A7 (GLUT7). (PubMed id 16186102)1, 9 Manolescu A....Cheeseman C.I. (2005)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Insight into the 'odd' hexose transporters GLUT3, GLUT5, and GLUT7. (PubMed id 18460594)9 Schurmann A. (2008)
|
External Searches for SLC2A7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing SLC2A7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing SLC2A7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC2A7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for SLC2A7 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for SLC2A7 gene:
Search GeneIP for patents involving SLC2A7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for SLC2A7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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