Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC2A6 Gene

Aliases for SLC2A6 Gene

  • Solute Carrier Family 2 Member 6 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 6 2 3 5
  • Glucose Transporter Type 6 3 4
  • Glucose Transporter Type 9 3 4
  • GLUT-6 3 4
  • GLUT-9 3 4
  • GLUT9 3 4
  • HSA011372 3
  • GLUT6 3

External Ids for SLC2A6 Gene

Previous GeneCards Identifiers for SLC2A6 Gene

  • GC09M127425
  • GC09M127893
  • GC09M129689
  • GC09M131612
  • GC09M133366
  • GC09M135326
  • GC09M136336
  • GC09M105837

Summaries for SLC2A6 Gene

Entrez Gene Summary for SLC2A6 Gene

  • Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

GeneCards Summary for SLC2A6 Gene

SLC2A6 (Solute Carrier Family 2 Member 6) is a Protein Coding gene. Diseases associated with SLC2A6 include hypouricemia, renal, 2 and testis seminoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A8.

UniProtKB/Swiss-Prot for SLC2A6 Gene

  • Facilitative glucose transporter; binds cytochalasin B with low affinity.

Gene Wiki entry for SLC2A6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A6 Gene

Genomics for SLC2A6 Gene

Regulatory Elements for SLC2A6 Gene

Promoters for SLC2A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC2A6 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A6 Gene

Chromosome:
9
Start:
133,471,094 bp from pter
End:
133,479,154 bp from pter
Size:
8,061 bases
Orientation:
Minus strand

Genomic View for SLC2A6 Gene

Genes around SLC2A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A6 Gene

Proteins for SLC2A6 Gene

  • Protein details for SLC2A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UGQ3-GTR6_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 6
    Protein Accession:
    Q9UGQ3
    Secondary Accessions:
    • A6NNU6
    • Q5SXD7
    • Q8NCC2

    Protein attributes for SLC2A6 Gene

    Size:
    507 amino acids
    Molecular mass:
    54539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A6 Gene

Proteomics data for SLC2A6 Gene at MOPED

Post-translational modifications for SLC2A6 Gene

  • Glycosylation at Asn 370
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A6 Gene

Antibody Products

No data available for DME Specific Peptides for SLC2A6 Gene

Domains & Families for SLC2A6 Gene

Gene Families for SLC2A6 Gene

Suggested Antigen Peptide Sequences for SLC2A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UGQ3

UniProtKB/Swiss-Prot:

GTR6_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A6: view

Function for SLC2A6 Gene

Molecular function for SLC2A6 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter; binds cytochalasin B with low affinity.

Gene Ontology (GO) - Molecular Function for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A6: view
genes like me logo Genes that share phenotypes with SLC2A6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A6

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A6 Gene

Localization for SLC2A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A6 Gene

Cell membrane; Multi-pass membrane protein. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A6 Gene COMPARTMENTS Subcellular localization image for SLC2A6 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA,NAS 10970791
genes like me logo Genes that share ontologies with SLC2A6: view

Pathways & Interactions for SLC2A6 Gene

genes like me logo Genes that share pathways with SLC2A6: view

Interacting Proteins for SLC2A6 Gene

Gene Ontology (GO) - Biological Process for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046323 glucose import IBA --
GO:1904659 glucose transmembrane transport NAS,TAS --
genes like me logo Genes that share ontologies with SLC2A6: view

No data available for SIGNOR curated interactions for SLC2A6 Gene

Drugs & Compounds for SLC2A6 Gene

(6) Drugs for SLC2A6 Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0

(6) Additional Compounds for SLC2A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC2A6 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC2A6: view

Transcripts for SLC2A6 Gene

Unigene Clusters for SLC2A6 Gene

Solute carrier family 2 (facilitated glucose transporter), member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: -
SP11:

Relevant External Links for SLC2A6 Gene

GeneLoc Exon Structure for
SLC2A6
ECgene alternative splicing isoforms for
SLC2A6

Expression for SLC2A6 Gene

mRNA expression in normal human tissues for SLC2A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A6 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SLC2A6 Gene

This gene is overexpressed in Bone (42.0), Peripheral blood mononuclear cells (8.1), Blymphocyte (7.1), and Islet of Langerhans (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A6 Gene



SOURCE GeneReport for Unigene cluster for SLC2A6 Gene Hs.244378

mRNA Expression by UniProt/SwissProt for SLC2A6 Gene

Q9UGQ3-GTR6_HUMAN
Tissue specificity: Highly expressed in brain, spleen and peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with SLC2A6: view

Protein tissue co-expression partners for SLC2A6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SLC2A6 Gene

Orthologs for SLC2A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC2A6 35
  • 87.31 (n)
  • 87.57 (a)
SLC2A6 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A6 35
  • 87.77 (n)
  • 87.97 (a)
SLC2A6 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a6 35
  • 82.76 (n)
  • 83.64 (a)
Slc2a6 16
Slc2a6 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC2A6 35
  • 99.54 (n)
  • 99.8 (a)
SLC2A6 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A6 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A6 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A6 35
  • 68.77 (n)
  • 66.47 (a)
SLC2A6 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A6 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a6 35
  • 61.84 (n)
  • 59.47 (a)
zebrafish
(Danio rerio)
Actinopterygii slc2a6 35
  • 58.46 (n)
  • 57.02 (a)
slc2a6 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG1208 37
  • 29 (a)
CG1213 37
  • 29 (a)
CG15406 37
  • 26 (a)
CG4797 37
  • 24 (a)
CG6484 37
  • 29 (a)
CG8234 37
  • 32 (a)
CG8249 37
  • 26 (a)
sut4 37
  • 30 (a)
Tret1-1 35
  • 48.23 (n)
  • 34.56 (a)
CG10960 36
  • 25 (a)
ManyToMany
CG1208 36
  • 27 (a)
ManyToMany
CG1213 36
  • 28 (a)
ManyToMany
CG14605 36
  • 23 (a)
ManyToMany
CG14606 36
  • 25 (a)
ManyToMany
CG15406 36
  • 24 (a)
ManyToMany
CG15408 36
  • 21 (a)
ManyToMany
CG31100 36
  • 18 (a)
ManyToMany
CG3285 36
  • 22 (a)
ManyToMany
CG33281 36
  • 24 (a)
ManyToMany
CG33282 36
  • 21 (a)
ManyToMany
CG4607 36
  • 23 (a)
ManyToMany
CG4797 36
  • 20 (a)
ManyToMany
CG6484 36
  • 28 (a)
ManyToMany
CG8249 36
  • 24 (a)
ManyToMany
CG8837 36
  • 20 (a)
ManyToMany
Glut3 36
  • 22 (a)
ManyToMany
sut4 36
  • 29 (a)
ManyToMany
Tret1-1 36
  • 17 (a)
ManyToMany
Tret1-2 36
  • 30 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta TRET1_ANOGA 35
  • 48.16 (n)
  • 33.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GAL2 36
  • 19 (a)
ManyToMany
HXT1 36
  • 19 (a)
ManyToMany
HXT10 36
  • 20 (a)
ManyToMany
HXT11 36
  • 19 (a)
ManyToMany
HXT13 36
  • 19 (a)
ManyToMany
HXT14 36
  • 20 (a)
ManyToMany
HXT15 36
  • 18 (a)
ManyToMany
HXT16 36
  • 18 (a)
ManyToMany
HXT17 36
  • 18 (a)
ManyToMany
HXT2 36
  • 21 (a)
ManyToMany
HXT3 36
  • 19 (a)
ManyToMany
HXT4 36
  • 19 (a)
ManyToMany
HXT5 36
  • 20 (a)
ManyToMany
HXT6 36
  • 19 (a)
ManyToMany
HXT7 36
  • 19 (a)
ManyToMany
HXT8 36
  • 19 (a)
ManyToMany
HXT9 36
  • 19 (a)
ManyToMany
RGT2 36
  • 15 (a)
ManyToMany
SNF3 36
  • 12 (a)
ManyToMany
STL1 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
ManyToMany
CSA.10291 36
  • 32 (a)
ManyToMany
Species with no ortholog for SLC2A6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A6 Gene

ENSEMBL:
Gene Tree for SLC2A6 (if available)
TreeFam:
Gene Tree for SLC2A6 (if available)

Paralogs for SLC2A6 Gene

Paralogs for SLC2A6 Gene

(1) SIMAP similar genes for SLC2A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC2A6: view

Variants for SLC2A6 Gene

Sequence variations from dbSNP and Humsavar for SLC2A6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3094378 - 133,472,046(-) CCGCA(A/C/G/T)GGGGA nc-transcript-variant, downstream-variant-500B, reference, missense
rs968471 -- 133,479,491(-) AGGTG(C/T)GCATT upstream-variant-2KB
rs2073935 -- 133,475,078(-) GCCCC(A/C)CACGT nc-transcript-variant, reference, synonymous-codon, utr-variant-3-prime
rs3094326 -- 133,478,525(+) CAGGC(C/G)TCCCT intron-variant
rs3124757 -- 133,480,981(-) CTATA(C/T)TTAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC2A6 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
dgv8325n71 CNV Loss 21882294
nsv894081 CNV Loss 21882294
dgv8328n71 CNV Loss 21882294
nsv894086 CNV Gain 21882294
nsv894094 CNV Loss 21882294
nsv894096 CNV Loss 21882294
nsv894097 CNV Loss 21882294
dgv8330n71 CNV Loss 21882294

Variation tolerance for SLC2A6 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A6 Gene

HapMap Linkage Disequilibrium report
SLC2A6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A6 Gene

Disorders for SLC2A6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC2A6 Gene - From: OMIM and DISEASES

Disorder Aliases PubMed IDs
hypouricemia, renal, 2
  • uric acid concentration, serum, qtl 2
testis seminoma
  • seminoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A6

Genetic Association Database (GAD)
SLC2A6
Human Genome Epidemiology (HuGE) Navigator
SLC2A6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A6
genes like me logo Genes that share disorders with SLC2A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A6 Gene

Publications for SLC2A6 Gene

  1. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. (PMID: 10970791) Doege H. … Schuermann A. (Biochem. J. 2000) 2 3 4 67
  2. Association between GLUT9 and gout in Japanese men. (PMID: 20413573) Urano W. … Yamanaka H. (Ann. Rheum. Dis. 2010) 3
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3
  4. Transcriptional regulation of the vascular endothelial glycome by angiogenic and inflammatory signalling. (PMID: 20162350) Willhauck-Fleckenstein M. … Schwartz-Albiez R. (Angiogenesis 2010) 23
  5. A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. (PMID: 20421923) Bianchi L. … DA-ez-Sampedro A. (PLoS ONE 2010) 23

Products for SLC2A6 Gene

Sources for SLC2A6 Gene

Back to Top

Content