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Aliases for SLC2A6 Gene

Aliases for SLC2A6 Gene

  • Solute Carrier Family 2 Member 6 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 6 2 3
  • Glucose Transporter Type 6 3 4
  • Glucose Transporter Type 9 3 4
  • GLUT-6 3 4
  • GLUT-9 3 4
  • GLUT9 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 6 3
  • HSA011372 3
  • GLUT6 3

External Ids for SLC2A6 Gene

Previous GeneCards Identifiers for SLC2A6 Gene

  • GC09M127425
  • GC09M127893
  • GC09M129689
  • GC09M131612
  • GC09M133366
  • GC09M135326
  • GC09M136336
  • GC09M105837

Summaries for SLC2A6 Gene

Entrez Gene Summary for SLC2A6 Gene

  • Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

GeneCards Summary for SLC2A6 Gene

SLC2A6 (Solute Carrier Family 2 Member 6) is a Protein Coding gene. Diseases associated with SLC2A6 include Testis Seminoma. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A8.

UniProtKB/Swiss-Prot for SLC2A6 Gene

  • Facilitative glucose transporter; binds cytochalasin B with low affinity.

Gene Wiki entry for SLC2A6 Gene

Additional gene information for SLC2A6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A6 Gene

Genomics for SLC2A6 Gene

Regulatory Elements for SLC2A6 Gene

Enhancers for SLC2A6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H133825 1.5 FANTOM5 Ensembl ENCODE dbSUPER 21.6 -347.1 -347071 1.8 CEBPB MAFG CEBPG ZIC2 POLR2A FOS NFE2 ATF7 MLLT1 MAFK SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
GH09H133112 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +350.2 350182 33.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 RALGDS GTF3C5 SETX BRD3 DDX31 TTF1 GTF3C4 TSC1 RPL7A GBGT1
GH09H133821 1.5 FANTOM5 ENCODE dbSUPER 13.1 -343.8 -343845 3.8 HDGF PKNOX1 PTBP1 TBL1XR1 ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 SLC2A6 VAV2 DBH RPL7A GC09P133784 GC09M133930
GH09H133843 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.8 -366.0 -365970 3.2 STAT1 MAX ZIC2 RAD21 NR2F2 ZNF23 MLLT1 NFE2 ENSG00000273473 SLC2A6 ENSG00000273249 TSC1 DBH-AS1 RPL7A GC09P133784 GC09M133930
GH09H133861 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -384.3 -384339 3.4 PKNOX1 ESRRA ZFP64 SIN3A RAD21 CTBP1 GATA3 FOS SMARCE1 MAZ SLC2A6 RXRA GC09P133784 GC09M133930
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC2A6 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for SLC2A6 Gene

Genomic Locations for SLC2A6 Gene
8,061 bases
Minus strand

Genomic View for SLC2A6 Gene

Genes around SLC2A6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A6 Gene

Proteins for SLC2A6 Gene

  • Protein details for SLC2A6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 6
    Protein Accession:
    Secondary Accessions:
    • A6NNU6
    • Q5SXD7
    • Q8NCC2

    Protein attributes for SLC2A6 Gene

    507 amino acids
    Molecular mass:
    54539 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A6 Gene


neXtProt entry for SLC2A6 Gene

Post-translational modifications for SLC2A6 Gene

  • Glycosylation at isoforms=370
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A6 Gene

Domains & Families for SLC2A6 Gene

Gene Families for SLC2A6 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A6: view

Function for SLC2A6 Gene

Molecular function for SLC2A6 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter; binds cytochalasin B with low affinity.

Gene Ontology (GO) - Molecular Function for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity NAS 10970791
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A6: view
genes like me logo Genes that share phenotypes with SLC2A6: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A6 Gene

Localization for SLC2A6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A6 Gene

Cell membrane; Multi-pass membrane protein. Note=The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A6 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA,NAS 10970791
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC2A6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A6 Gene

Pathways & Interactions for SLC2A6 Gene

genes like me logo Genes that share pathways with SLC2A6: view

Interacting Proteins for SLC2A6 Gene

Gene Ontology (GO) - Biological Process for SLC2A6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transport TAS --
GO:0015992 proton transport IEA --
GO:0035428 hexose transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC2A6: view

No data available for SIGNOR curated interactions for SLC2A6 Gene

Drugs & Compounds for SLC2A6 Gene

(9) Drugs for SLC2A6 Gene - From: DrugBank, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved Pharma Transporter, substrate 0
Empagliflozin (BI 10773) Pharma SGLT-2 inhibitor for oral treatment of type 2 diabetes 0

(4) Additional Compounds for SLC2A6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SLC2A6 Gene

Compound Action Cas Number
Empagliflozin (BI 10773) SGLT-2 inhibitor for oral treatment of type 2 diabetes 864070-44-0
genes like me logo Genes that share compounds with SLC2A6: view

Drug Products

Transcripts for SLC2A6 Gene

Unigene Clusters for SLC2A6 Gene

Solute carrier family 2 (facilitated glucose transporter), member 6:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A6 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: - - - - - -
SP8: - -
SP9: - - - -
SP10: -

Relevant External Links for SLC2A6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A6 Gene

mRNA differential expression in normal tissues according to GTEx for SLC2A6 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for SLC2A6 Gene

This gene is overexpressed in Bone (42.0), Peripheral blood mononuclear cells (8.1), Blymphocyte (7.1), and Islet of Langerhans (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC2A6 Gene

Protein tissue co-expression partners for SLC2A6 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A6 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A6 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A6 Gene:

Tissue specificity: Highly expressed in brain, spleen and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for SLC2A6 Gene

  • Blood(4.2)
  • Kidney(4.2)
  • Nervous system(3.5)
genes like me logo Genes that share expression patterns with SLC2A6: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A6 Gene

Orthologs for SLC2A6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A6 33 34
  • 99.54 (n)
(Canis familiaris)
Mammalia SLC2A6 33 34
  • 87.77 (n)
(Bos Taurus)
Mammalia SLC2A6 33 34
  • 87.31 (n)
(Mus musculus)
Mammalia Slc2a6 33 16 34
  • 82.76 (n)
(Monodelphis domestica)
Mammalia SLC2A6 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia SLC2A6 34
  • 66 (a)
(Gallus gallus)
Aves SLC2A6 33 34
  • 68.77 (n)
(Anolis carolinensis)
Reptilia SLC2A6 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a6 33
  • 61.84 (n)
(Danio rerio)
Actinopterygii slc2a6 33 34
  • 58.46 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tret1-1 33 34
  • 48.23 (n)
CG8234 35
  • 32 (a)
sut4 35 34
  • 30 (a)
Tret1-2 34
  • 30 (a)
CG1208 35 34
  • 29 (a)
CG1213 35 34
  • 29 (a)
CG6484 35 34
  • 29 (a)
CG15406 35 34
  • 26 (a)
CG8249 35 34
  • 26 (a)
CG10960 34
  • 25 (a)
CG14606 34
  • 25 (a)
CG4797 35 34
  • 24 (a)
CG33281 34
  • 24 (a)
CG14605 34
  • 23 (a)
CG4607 34
  • 23 (a)
CG3285 34
  • 22 (a)
Glut3 34
  • 22 (a)
CG15408 34
  • 21 (a)
CG33282 34
  • 21 (a)
CG8837 34
  • 20 (a)
CG31100 34
  • 18 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta TRET1_ANOGA 33
  • 48.16 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HXT2 34
  • 21 (a)
HXT10 34
  • 20 (a)
HXT14 34
  • 20 (a)
HXT5 34
  • 20 (a)
GAL2 34
  • 19 (a)
HXT1 34
  • 19 (a)
HXT11 34
  • 19 (a)
HXT13 34
  • 19 (a)
HXT3 34
  • 19 (a)
HXT4 34
  • 19 (a)
HXT6 34
  • 19 (a)
HXT7 34
  • 19 (a)
HXT8 34
  • 19 (a)
HXT9 34
  • 19 (a)
STL1 34
  • 19 (a)
HXT15 34
  • 18 (a)
HXT16 34
  • 18 (a)
HXT17 34
  • 18 (a)
RGT2 34
  • 15 (a)
SNF3 34
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
CSA.10291 34
  • 32 (a)
Species where no ortholog for SLC2A6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A6 Gene

Gene Tree for SLC2A6 (if available)
Gene Tree for SLC2A6 (if available)

Paralogs for SLC2A6 Gene

Paralogs for SLC2A6 Gene

(1) SIMAP similar genes for SLC2A6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC2A6: view

Variants for SLC2A6 Gene

Sequence variations from dbSNP and Humsavar for SLC2A6 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000030934 -- 133,479,015(+) GGGAA(A/G)GTGTC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000617866 -- 133,475,943(+) CTTCC(C/T)ATCTG intron-variant
rs1000758339 -- 133,476,294(+) CCCCA(A/G)AGCCC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime
rs1000959424 -- 133,471,570(+) TAAGA(C/G)TTGTG nc-transcript-variant, utr-variant-3-prime
rs1000979171 -- 133,471,568(+) CATAA(A/G)ACTTG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC2A6 Gene

Variant ID Type Subtype PubMed ID
nsv951799 CNV deletion 24416366
nsv1125319 OTHER inversion 24896259
esv2739138 CNV deletion 23290073

Variation tolerance for SLC2A6 Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.50; 55.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A6 Gene

Disorders for SLC2A6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SLC2A6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testis seminoma
  • seminoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC2A6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A6 Gene

Publications for SLC2A6 Gene

  1. Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes. (PMID: 10970791) Doege H … Schürmann A (The Biochemical journal 2000) 2 3 4 60
  2. Association between GLUT9 and gout in Japanese men. (PMID: 20413573) Urano W … Yamanaka H (Annals of the rheumatic diseases 2010) 3 45 60
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C … Hunter DJ (Human genetics 2010) 3 45 60
  4. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for SLC2A6 Gene

Sources for SLC2A6 Gene

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