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Aliases for SLC2A5 Gene

Aliases for SLC2A5 Gene

  • Solute Carrier Family 2 Member 5 2 3
  • Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5 2 3 5
  • Glucose Transporter Type 5, Small Intestine 3 4
  • GLUT-5 3 4
  • GLUT5 3 4
  • Glucose Transporter-Like Protein 5 3
  • Testicular Tissue Protein Li 81 3
  • Fructose Transporter 4

External Ids for SLC2A5 Gene

Previous HGNC Symbols for SLC2A5 Gene

  • GLUT5

Previous GeneCards Identifiers for SLC2A5 Gene

  • GC01M008717
  • GC01M008908
  • GC01M008772
  • GC01M009031
  • GC01M009019
  • GC01M008246

Summaries for SLC2A5 Gene

GeneCards Summary for SLC2A5 Gene

SLC2A5 (Solute Carrier Family 2 Member 5) is a Protein Coding gene. Diseases associated with SLC2A5 include Testis Seminoma and Testicular Malignant Germ Cell Cancer. Among its related pathways are Glycosaminoglycan metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A5 Gene

  • Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A5 Gene

Genomics for SLC2A5 Gene

Regulatory Elements for SLC2A5 Gene

Enhancers for SLC2A5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC2A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A5 Gene

Chromosome:
1
Start:
9,035,107 bp from pter
End:
9,088,478 bp from pter
Size:
53,372 bases
Orientation:
Minus strand

Genomic View for SLC2A5 Gene

Genes around SLC2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A5 Gene

Proteins for SLC2A5 Gene

  • Protein details for SLC2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22732-GTR5_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 5
    Protein Accession:
    P22732
    Secondary Accessions:
    • Q14770
    • Q5T977
    • Q8IVB3

    Protein attributes for SLC2A5 Gene

    Size:
    501 amino acids
    Molecular mass:
    54974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60641.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC2A5 Gene

    Alternative splice isoforms for SLC2A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A5 Gene

Proteomics data for SLC2A5 Gene at MOPED

Post-translational modifications for SLC2A5 Gene

  • Glycosylation at Asn 51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A5 Gene

Domains & Families for SLC2A5 Gene

Gene Families for SLC2A5 Gene

Graphical View of Domain Structure for InterPro Entry

P22732

UniProtKB/Swiss-Prot:

GTR5_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A5: view

Function for SLC2A5 Gene

Molecular function for SLC2A5 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A5,facilitated glucose transporter
UniProtKB/Swiss-Prot EnzymeRegulation:
The uptake of 2-deoxyglucose is inhibited by cytochalasin B.
UniProtKB/Swiss-Prot Function:
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
UniProtKB/Swiss-Prot Induction:
By forskolin in Caco-2 cells.
genes like me logo Genes that share phenotypes with SLC2A5: view

Animal Models for SLC2A5 Gene

MGI Knock Outs for SLC2A5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A5

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A5 Gene

Localization for SLC2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A5 Gene

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250 UniProtKB:Q9WV38}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A5 Gene COMPARTMENTS Subcellular localization image for SLC2A5 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 8333543
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A5: view

Pathways & Interactions for SLC2A5 Gene

genes like me logo Genes that share pathways with SLC2A5: view

Pathways by source for SLC2A5 Gene

Interacting Proteins for SLC2A5 Gene

Gene Ontology (GO) - Biological Process for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal ISS --
GO:0009750 response to fructose ISS --
GO:0015755 fructose transport IEA,TAS 1634504
GO:0015758 glucose transport TAS 1695905
GO:0055085 transmembrane transport IEA --
genes like me logo Genes that share ontologies with SLC2A5: view

No data available for SIGNOR curated interactions for SLC2A5 Gene

Drugs & Compounds for SLC2A5 Gene

(3) Drugs for SLC2A5 Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glufosfamide Pharma inhibitor 0

(8) Additional Compounds for SLC2A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A5: view

Transcripts for SLC2A5 Gene

Unigene Clusters for SLC2A5 Gene

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SLC2A5 Gene

GeneLoc Exon Structure for
SLC2A5
ECgene alternative splicing isoforms for
SLC2A5

Expression for SLC2A5 Gene

mRNA expression in normal human tissues for SLC2A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.1), Brain - Spinal cord (cervical c-1) (x4.3), Testis (x4.2), and Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for SLC2A5 Gene

This gene is overexpressed in Urine (59.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A5 Gene



SOURCE GeneReport for Unigene cluster for SLC2A5 Gene Hs.530003

mRNA Expression by UniProt/SwissProt for SLC2A5 Gene

P22732-GTR5_HUMAN
Tissue specificity: Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.
genes like me logo Genes that share expression patterns with SLC2A5: view

Primer Products

No data available for Protein tissue co-expression partners for SLC2A5 Gene

Orthologs for SLC2A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC2A5 35
  • 80.84 (n)
  • 80.24 (a)
SLC2A5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A5 35
  • 83.97 (n)
  • 85.03 (a)
SLC2A5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a5 35
  • 79.53 (n)
  • 83 (a)
Slc2a5 16
Slc2a5 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC2A5 35
  • 99.33 (n)
  • 99.6 (a)
SLC2A5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a5 35
  • 80.27 (n)
  • 81.8 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC2A5 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC2A5 35
  • 66.73 (n)
  • 64.99 (a)
SLC2A5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A5 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a5 35
  • 61.85 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii wufc10e01 35
slc2a5 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7882 37
  • 29 (a)
sut1 37
  • 34 (a)
sut2 37
  • 30 (a)
sut3 37
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 37
  • 37 (a)
H17B01.1b 37
  • 37 (a)
R09B5.11 37
  • 32 (a)
Y61A9LA.1 37
  • 22 (a)
Species with no ortholog for SLC2A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A5 Gene

ENSEMBL:
Gene Tree for SLC2A5 (if available)
TreeFam:
Gene Tree for SLC2A5 (if available)

Paralogs for SLC2A5 Gene

genes like me logo Genes that share paralogs with SLC2A5: view

Variants for SLC2A5 Gene

Sequence variations from dbSNP and Humsavar for SLC2A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5438 -- 9,069,561(-) TGAGC(A/G)GCACT utr-variant-5-prime
rs5840 -- 9,037,182(+) CCTGT(C/T)GGGGC utr-variant-3-prime
rs875995 -- 9,038,213(-) AGTGG(A/G)CCTAA intron-variant
rs875996 -- 9,038,171(-) CTGCC(A/G)TTTGC intron-variant
rs762605 -- 9,037,792(-) TCCCG(C/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A5 Gene

Variant ID Type Subtype PubMed ID
nsv462727 CNV Loss 19166990
nsv831981 CNV Loss 17160897
esv1504235 CNV Insertion 17803354
esv1740239 CNV Insertion 17803354
nsv512717 CNV Insertion 21212237

Variation tolerance for SLC2A5 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A5 Gene

Human Gene Mutation Database (HGMD)
SLC2A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A5 Gene

Disorders for SLC2A5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC2A5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testis seminoma
  • seminoma
testicular malignant germ cell cancer
  • malignant germ cell tumor of testis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A5

Genetic Association Database (GAD)
SLC2A5
Human Genome Epidemiology (HuGE) Navigator
SLC2A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A5
genes like me logo Genes that share disorders with SLC2A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A5 Gene

Publications for SLC2A5 Gene

  1. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PMID: 8037665) Mahraoui L. … Brot-Laroche E. (Biochem. J. 1994) 3 4 23 67
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White P.S. … Brodeur G.M. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells. (PMID: 18424253) Takabe S. … Goda T. (Arch. Biochem. Biophys. 2008) 3 23
  4. Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone. (PMID: 18439419) Mochizuki K. … Goda T. (Biochem. Biophys. Res. Commun. 2008) 3 23
  5. Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone. (PMID: 17251278) Stuart C.A. … Yin D. (Diabetes Care 2007) 3 23

Products for SLC2A5 Gene

Sources for SLC2A5 Gene

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