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Aliases for SLC2A5 Gene

Aliases for SLC2A5 Gene

  • Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5 2 3
  • GLUT5 3 4 6
  • Glucose Transporter Type 5, Small Intestine 3 4
  • GLUT-5 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 5 3
  • Glucose Transporter-Like Protein 5 3
  • Fructose Transporter 4

External Ids for SLC2A5 Gene

Previous HGNC Symbols for SLC2A5 Gene

  • GLUT5

Previous GeneCards Identifiers for SLC2A5 Gene

  • GC01M008717
  • GC01M008908
  • GC01M008772
  • GC01M009031
  • GC01M009019
  • GC01M008246

Summaries for SLC2A5 Gene

GeneCards Summary for SLC2A5 Gene

SLC2A5 (Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5) is a Protein Coding gene. Among its related pathways are PAK Pathway and Metabolism. GO annotations related to this gene include glucose transmembrane transporter activity and fructose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A5 Gene

  • Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A5 Gene

Genomics for SLC2A5 Gene

Regulatory Elements for SLC2A5 Gene

Genomic Location for SLC2A5 Gene

Start:
9,035,107 bp from pter
End:
9,088,478 bp from pter
Size:
53,372 bases
Orientation:
Minus strand

Genomic View for SLC2A5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A5 Gene

Proteins for SLC2A5 Gene

  • Protein details for SLC2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22732-GTR5_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 5
    Protein Accession:
    P22732
    Secondary Accessions:
    • Q14770
    • Q5T977
    • Q8IVB3

    Protein attributes for SLC2A5 Gene

    Size:
    501 amino acids
    Molecular mass:
    54974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60641.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC2A5 Gene

    Alternative splice isoforms for SLC2A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A5 Gene

Proteomics data for SLC2A5 Gene at MOPED

Post-translational modifications for SLC2A5 Gene

  • Glycosylation at Asn51
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC2A5 Gene

No data available for DME Specific Peptides for SLC2A5 Gene

Domains for SLC2A5 Gene

Gene Families for SLC2A5 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P22732

UniProtKB/Swiss-Prot:

GTR5_HUMAN :
  • P22732
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A5: view

Function for SLC2A5 Gene

Molecular function for SLC2A5 Gene

GENATLAS Biochemistry: solute carrier family 2,member A5,facilitated glucose transporter
UniProtKB/Swiss-Prot Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter
UniProtKB/Swiss-Prot Induction: By forskolin in Caco-2 cells.

Gene Ontology (GO) - Molecular Function for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005353 fructose transmembrane transporter activity IEA --
GO:0005355 glucose transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A5: view

Phenotypes for SLC2A5 Gene

genes like me logo Genes that share phenotypes with SLC2A5: view

Animal Models for SLC2A5 Gene

MGI Knock Outs for SLC2A5:

miRNA for SLC2A5 Gene

miRTarBase miRNAs that target SLC2A5

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC2A5 Gene

Localization for SLC2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A5 Gene

Apical cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized on the apical membrane of the small intestine and the proximal tubule of the kidney. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A5 Gene COMPARTMENTS Subcellular localization image for SLC2A5 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0016324 apical plasma membrane ISS --
genes like me logo Genes that share ontologies with SLC2A5: view

Pathways for SLC2A5 Gene

genes like me logo Genes that share pathways with SLC2A5: view

Interacting Proteins for SLC2A5 Gene

Gene Ontology (GO) - Biological Process for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008645 hexose transport TAS --
GO:0015755 fructose transport IEA --
GO:0015758 glucose transport TAS 1695905
GO:0015992 proton transport IBA --
genes like me logo Genes that share ontologies with SLC2A5: view

Compounds for SLC2A5 Gene

(10) Novoseek inferred chemical compound relationships for SLC2A5 Gene

Compound -log(P) Hits PubMed IDs
fructose 89 92
cytochalasin b 73.1 5
glucose 62.4 47
galactose 38.4 4
monosaccharide 34.5 1
genes like me logo Genes that share compounds with SLC2A5: view

Transcripts for SLC2A5 Gene

Unigene Clusters for SLC2A5 Gene

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SLC2A5 Gene

GeneLoc Exon Structure for
SLC2A5
ECgene alternative splicing isoforms for
SLC2A5

Expression for SLC2A5 Gene

mRNA expression in normal human tissues for SLC2A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (5.1), Brain - Spinal cord (cervical c-1) (4.3), Testis (4.2), and Muscle - Skeletal (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC2A5 Gene

SOURCE GeneReport for Unigene cluster for SLC2A5 Gene Hs.530003

mRNA Expression by UniProt/SwissProt for SLC2A5 Gene

P22732-GTR5_HUMAN
Tissue specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue
genes like me logo Genes that share expressions with SLC2A5: view

Orthologs for SLC2A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A5 35
  • 99.33 (n)
  • 99.6 (a)
SLC2A5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A5 35
  • 80.84 (n)
  • 80.24 (a)
SLC2A5 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A5 35
  • 83.97 (n)
  • 85.03 (a)
SLC2A5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a5 35
  • 79.53 (n)
  • 83 (a)
Slc2a5 16
Slc2a5 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A5 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Slc2a5 35
  • 80.27 (n)
  • 81.8 (a)
chicken
(Gallus gallus)
Aves SLC2A5 35
  • 66.73 (n)
  • 64.99 (a)
SLC2A5 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC2A5 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a5 35
  • 61.85 (n)
  • 63.86 (a)
zebrafish
(Danio rerio)
Actinopterygii slc2a5 36
  • 66 (a)
OneToOne
wufc10e01 35
fruit fly
(Drosophila melanogaster)
Insecta CG7882 37
  • 29 (a)
sut3 37
  • 27 (a)
sut1 37
  • 34 (a)
sut2 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 37
  • 37 (a)
R09B5.11 37
  • 32 (a)
H17B01.1b 37
  • 37 (a)
Y61A9LA.1 37
  • 22 (a)
Species with no ortholog for SLC2A5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A5 Gene

ENSEMBL:
Gene Tree for SLC2A5 (if available)
TreeFam:
Gene Tree for SLC2A5 (if available)

Paralogs for SLC2A5 Gene

genes like me logo Genes that share paralogs with SLC2A5: view

Variants for SLC2A5 Gene

Sequence variations from dbSNP and Humsavar for SLC2A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs5438 -- 9,069,561(-) TGAGC(A/G)GCACT utr-variant-5-prime, upstream-variant-2KB
rs5840 -- 9,037,182(+) CCTGT(C/T)GGGGC utr-variant-3-prime
rs762605 -- 9,037,792(-) TCCCG(C/T)AGGAG intron-variant
rs765615 -- 9,061,628(-) GAATT(A/G)GAAAA intron-variant
rs765616 -- 9,061,620(-) AAAGA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A5 Gene

Variant ID Type Subtype PubMed ID
nsv462727 CNV Loss 19166990
nsv831981 CNV Loss 17160897
esv1504235 CNV Insertion 17803354
esv1740239 CNV Insertion 17803354
nsv512717 CNV Insertion 21212237

Relevant External Links for SLC2A5 Gene

HapMap Linkage Disequilibrium report
SLC2A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A5 Gene

Disorders for SLC2A5 Gene

(5) Novoseek inferred disease relationships for SLC2A5 Gene

Disease -log(P) Hits PubMed IDs
malabsorption 22.9 2
cancer 4.01 2
colon cancer 0 1
breast cancer 0 2
tumors 0 3

Relevant External Links for SLC2A5

Genetic Association Database (GAD)
SLC2A5
Human Genome Epidemiology (HuGE) Navigator
SLC2A5
genes like me logo Genes that share disorders with SLC2A5: view

No data available for UniProtKB/Swiss-Prot for SLC2A5 Gene

Publications for SLC2A5 Gene

  1. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PMID: 8037665) Mahraoui L. … Brot-Laroche E. (Biochem. J. 1994) 3 4 23
  2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White P.S. … Brodeur G.M. (Cytogenet. Cell Genet. 1998) 2 3 23
  3. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PMID: 1695905) Kayano T. … Bell G.I. (J. Biol. Chem. 1990) 3 4 23
  4. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PMID: 12820898) Gouyon F. … Brot-Laroche E. (Biochem. J. 2003) 3 23
  5. Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle. (PMID: 16803853) Stuart C.A. … Ferrando A.A. (Am. J. Physiol. Endocrinol. Metab. 2006) 3 23

Products for SLC2A5 Gene

Sources for SLC2A5 Gene

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