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Aliases for SLC2A5 Gene

Aliases for SLC2A5 Gene

  • Solute Carrier Family 2 Member 5 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5 2 3
  • Glucose Transporter Type 5, Small Intestine 3 4
  • GLUT-5 3 4
  • GLUT5 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 5 3
  • Glucose Transporter-Like Protein 5 3
  • Testicular Tissue Protein Li 81 3
  • Fructose Transporter 4

External Ids for SLC2A5 Gene

Previous HGNC Symbols for SLC2A5 Gene

  • GLUT5

Previous GeneCards Identifiers for SLC2A5 Gene

  • GC01M008717
  • GC01M008908
  • GC01M008772
  • GC01M009031
  • GC01M009019
  • GC01M008246

Summaries for SLC2A5 Gene

Entrez Gene Summary for SLC2A5 Gene

  • The protein encoded by this gene is a fructose transporter responsible for fructose uptake by the small intestine. The encoded protein also is necessary for the increase in blood pressure due to high dietary fructose consumption. [provided by RefSeq, Jun 2016]

GeneCards Summary for SLC2A5 Gene

SLC2A5 (Solute Carrier Family 2 Member 5) is a Protein Coding gene. Diseases associated with SLC2A5 include Testis Seminoma and Hemophagocytic Lymphohistiocytosis, Familial, 5. Among its related pathways are Metabolism and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A7.

UniProtKB/Swiss-Prot for SLC2A5 Gene

  • Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).

Additional gene information for SLC2A5 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A5 Gene

Genomics for SLC2A5 Gene

Regulatory Elements for SLC2A5 Gene

Enhancers for SLC2A5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H009066 1.6 FANTOM5 Ensembl ENCODE 29.5 +20.0 20021 4 HDGF MLX ZFP64 SIN3A ARID4B DMAP1 SLC30A9 ZNF143 FOS ATF7 SLC2A5 SLC2A7 RNU6-304P GC01P009083 PIR51806
GH01H009061 0.7 Ensembl ENCODE 29 +26.1 26068 1 NR2F1 HNF4A ZIC2 SLC2A5 GC01P009083 PIR51806
GH01H009077 1.2 Ensembl ENCODE 13.2 +8.9 8851 3 HDGF PKNOX1 ZNF766 ELK1 FOS ATF7 RUNX3 JUNB ZNF592 MEF2D SLC2A5 RERE GPR157 GC01P009083 PIR51806
GH01H009005 1.1 Ensembl ENCODE 12.2 +83.2 83181 0 PKNOX1 ATF1 RB1 KLF17 RAD21 EGR1 ZNF143 ATF7 CREM EGR2 SLC2A7 SLC2A5 RNU6-304P MIR34A GC01M008979 RN7SL451P
GH01H009036 0.8 ENCODE 16.6 +51.0 51024 2 PKNOX1 ATF1 BATF RELA CTBP1 POLR2A EED FOS ETV6 RUNX3 SLC2A5 PIR51806 GC01P009083
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC2A5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A5 Gene

Chromosome:
1
Start:
9,035,107 bp from pter
End:
9,088,478 bp from pter
Size:
53,372 bases
Orientation:
Minus strand

Genomic View for SLC2A5 Gene

Genes around SLC2A5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A5 Gene

Proteins for SLC2A5 Gene

  • Protein details for SLC2A5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22732-GTR5_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 5
    Protein Accession:
    P22732
    Secondary Accessions:
    • Q14770
    • Q5T977
    • Q8IVB3

    Protein attributes for SLC2A5 Gene

    Size:
    501 amino acids
    Molecular mass:
    54974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB60641.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SLC2A5 Gene

    Alternative splice isoforms for SLC2A5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A5 Gene

Post-translational modifications for SLC2A5 Gene

  • Glycosylation at Asn51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A5 Gene

Domains & Families for SLC2A5 Gene

Gene Families for SLC2A5 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P22732

UniProtKB/Swiss-Prot:

GTR5_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A5: view

Function for SLC2A5 Gene

Molecular function for SLC2A5 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A5,facilitated glucose transporter
UniProtKB/Swiss-Prot EnzymeRegulation:
The uptake of 2-deoxyglucose is inhibited by cytochalasin B.
UniProtKB/Swiss-Prot Function:
Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine. Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose. Required for the development of high blood pressure in response to high dietary fructose intake (By similarity).
UniProtKB/Swiss-Prot Induction:
By forskolin in Caco-2 cells.

Phenotypes From GWAS Catalog for SLC2A5 Gene

Gene Ontology (GO) - Molecular Function for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IEA --
GO:0005353 fructose transmembrane transporter activity TAS,IEA --
GO:0005355 glucose transmembrane transporter activity TAS 1695905
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A5: view
genes like me logo Genes that share phenotypes with SLC2A5: view

Animal Models for SLC2A5 Gene

MGI Knock Outs for SLC2A5:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A5

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC2A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC2A5 Gene

Localization for SLC2A5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A5 Gene

Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250 UniProtKB:Q9WV38}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A5 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IDA 8333543
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane ISS --
genes like me logo Genes that share ontologies with SLC2A5: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A5 Gene

Pathways & Interactions for SLC2A5 Gene

genes like me logo Genes that share pathways with SLC2A5: view

Pathways by source for SLC2A5 Gene

Gene Ontology (GO) - Biological Process for SLC2A5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal ISS --
GO:0005975 carbohydrate metabolic process TAS 1634504
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0009750 response to fructose ISS --
genes like me logo Genes that share ontologies with SLC2A5: view

No data available for SIGNOR curated interactions for SLC2A5 Gene

Drugs & Compounds for SLC2A5 Gene

(6) Drugs for SLC2A5 Gene - From: DrugBank, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludeoxyglucose F-18 Approved Pharma Transporter, substrate 0
Glufosfamide Pharma inhibitor 0

(6) Additional Compounds for SLC2A5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A5: view

Transcripts for SLC2A5 Gene

Unigene Clusters for SLC2A5 Gene

Solute carrier family 2 (facilitated glucose/fructose transporter), member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SLC2A5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: -
SP2: -
SP3: - -
SP4: - -

Relevant External Links for SLC2A5 Gene

GeneLoc Exon Structure for
SLC2A5
ECgene alternative splicing isoforms for
SLC2A5

Expression for SLC2A5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x5.1), Brain - Spinal cord (cervical c-1) (x4.3), Testis (x4.2), and Muscle - Skeletal (x4.0).

Protein differential expression in normal tissues from HIPED for SLC2A5 Gene

This gene is overexpressed in Urine (59.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A5 Gene



NURSA nuclear receptor signaling pathways regulating expression of SLC2A5 Gene:

SLC2A5

SOURCE GeneReport for Unigene cluster for SLC2A5 Gene:

Hs.530003

mRNA Expression by UniProt/SwissProt for SLC2A5 Gene:

P22732-GTR5_HUMAN
Tissue specificity: Detected in skeletal muscle, and in jejunum brush border membrane and basolateral membrane (at protein level) (PubMed:7619085). Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Evidence on tissue expression from TISSUES for SLC2A5 Gene

  • Nervous system(4.8)
  • Intestine(4.6)
  • Blood(4.4)
  • Kidney(3.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with SLC2A5: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A5 Gene

Orthologs for SLC2A5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A5 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia SLC2A5 33 34
  • 83.97 (n)
cow
(Bos Taurus)
Mammalia SLC2A5 33 34
  • 80.84 (n)
rat
(Rattus norvegicus)
Mammalia Slc2a5 33
  • 80.27 (n)
mouse
(Mus musculus)
Mammalia Slc2a5 33 16 34
  • 79.53 (n)
oppossum
(Monodelphis domestica)
Mammalia SLC2A5 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC2A5 33 34
  • 66.73 (n)
lizard
(Anolis carolinensis)
Reptilia SLC2A5 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a5 33
  • 61.85 (n)
zebrafish
(Danio rerio)
Actinopterygii slc2a5 34
  • 66 (a)
OneToOne
wufc10e01 33
fruit fly
(Drosophila melanogaster)
Insecta sut1 35
  • 34 (a)
sut2 35
  • 30 (a)
CG7882 35
  • 29 (a)
sut3 35
  • 27 (a)
worm
(Caenorhabditis elegans)
Secernentea H17B01.1a 35
  • 37 (a)
H17B01.1b 35
  • 37 (a)
R09B5.11 35
  • 32 (a)
Y61A9LA.1 35
  • 22 (a)
Species where no ortholog for SLC2A5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A5 Gene

ENSEMBL:
Gene Tree for SLC2A5 (if available)
TreeFam:
Gene Tree for SLC2A5 (if available)

Paralogs for SLC2A5 Gene

genes like me logo Genes that share paralogs with SLC2A5: view

Variants for SLC2A5 Gene

Sequence variations from dbSNP and Humsavar for SLC2A5 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs779760381 other 9,039,877(+) CATCC(A/G)GAACA reference, missense
rs1000060362 -- 9,094,325(+) AAAAA(A/T)AACTC upstream-variant-2KB
rs1000065863 -- 9,087,123(+) AACTC(A/G)GCCAG intron-variant
rs1000108968 -- 9,045,591(+) AGGGC(A/G)AGATG intron-variant
rs1000110529 -- 9,073,940(+) CCAGG(A/C)TTGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC2A5 Gene

Variant ID Type Subtype PubMed ID
dgv15n100 CNV loss 25217958
esv1504235 CNV insertion 17803354
esv1740239 CNV insertion 17803354
esv3542788 CNV deletion 23714750
esv3577721 CNV loss 25503493
esv3585161 CNV gain 21293372
nsv1004025 CNV gain 25217958
nsv462727 CNV loss 19166990
nsv512717 CNV insertion 21212237
nsv545347 CNV loss 21841781
nsv831981 CNV loss 17160897

Variation tolerance for SLC2A5 Gene

Residual Variation Intolerance Score: 79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.77; 47.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A5 Gene

Human Gene Mutation Database (HGMD)
SLC2A5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A5 Gene

Disorders for SLC2A5 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SLC2A5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
testis seminoma
  • seminoma
hemophagocytic lymphohistiocytosis, familial, 5
  • familial hemophagocytic lymphohistiocytosis 5
testicular malignant germ cell cancer
  • malignant germ cell tumor of testis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A5

Genetic Association Database (GAD)
SLC2A5
Human Genome Epidemiology (HuGE) Navigator
SLC2A5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A5
genes like me logo Genes that share disorders with SLC2A5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A5 Gene

Publications for SLC2A5 Gene

  1. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PMID: 9691177) White PS … Brodeur GM (Cytogenetics and cell genetics 1998) 2 3 22 60
  2. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PMID: 8037665) Mahraoui L … Brot-Laroche E (The Biochemical journal 1994) 3 4 22 60
  3. Sequence, tissue distribution, and functional characterization of the rat fructose transporter GLUT5. (PMID: 8333543) Rand EB … Burant CF (The American journal of physiology 1993) 3 4 22 60
  4. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PMID: 1695905) Kayano T … Bell GI (The Journal of biological chemistry 1990) 3 4 22 60
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60

Products for SLC2A5 Gene

Sources for SLC2A5 Gene

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