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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC2A5 Gene

protein-coding   GIFtS: 61
GCID: GC01M009095

Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter),...


(Previous symbol: GLUT5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter),
Member 51 2
     Glucose Transporter-Like Protein 52
GLUT51 2 3 5     Solute Carrier Family 2, Facilitated Glucose Transporter Member 52
Glucose Transporter Type 5, Small Intestine2 3     Fructose Transporter3
GLUT-52 3     

External Ids:    HGNC: 110101   Entrez Gene: 65182   Ensembl: ENSG000001425837   OMIM: 1382305   UniProtKB: P227323   

Export aliases for SLC2A5 gene to outside databases

Previous GC identifers: GC01M008717 GC01M008908 GC01M008772 GC01M009031 GC01M009019 GC01M008246


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC2A5 Gene: 
SLC2A5 (solute carrier family 2 (facilitated glucose/fructose transporter), member 5) is a protein-coding gene. Diseases associated with SLC2A5 include gout, and choriocarcinoma, and among its related super-pathways are Transmembrane transport of small molecules and Class II GLUTs. GO annotations related to this gene include fructose transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_021937.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A5 gene promoter:
         GR   AREB6   Tal-1   Pbx1a   GR-beta   GR-alpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A5 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC2A5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M009095:  view genomic region     (about GC identifiers)

Start:
9,095,166 bp from pter      End:
9,148,537 bp from pter
Size:
53,372 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 5  
Size: 501 amino acids; 54974 Da
Subcellular location: Membrane; Multi-pass membrane protein
Mass spectrometry: Mass=54973.98; Method=MALDI; Range=1-501; Source=PubMed:11840567;
Sequence caution: Sequence=AAB60641.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for SLC2A5:
1YG1 (3D)    
Secondary accessions: Q14770 Q5T977 Q8IVB3
Alternative splicing: 2 isoforms:  P22732-1   P22732-2   

Explore the universe of human proteins at neXtProt for SLC2A5: NX_P22732

Explore proteomics data for SLC2A5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P22732

  • SLC2A5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC2A5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129057.1  NP_003030.1  

    ENSEMBL proteins: 
     ENSP00000366641   ENSP00000366631   ENSP00000467039   ENSP00000464880   ENSP00000468590  
     ENSP00000465507   ENSP00000465382   ENSP00000467840   ENSP00000465285   ENSP00000440688  
     ENSP00000442744  
    Reactome Protein details: P22732
    Human Recombinant Protein Products for SLC2A5: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0016324apical plasma membrane ISS--

    SLC2A5 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 5 
    Class II transporters

    5/6 InterPro protein domains (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR002442 Fru_transpt_5
     IPR020846 MFS_dom

    Graphical View of Domain Structure for InterPro Entry P22732

    ProtoNet protein and cluster: P22732

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002442 Fructose transporter (GLUT5) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR5_HUMAN, P22732
    Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter
    Induction: By forskolin in Caco-2 cells

         Genatlas biochemistry entry for SLC2A5:
    solute carrier family 2,member A5,facilitated glucose transporter

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005353fructose transmembrane transporter activity IEA--
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    SLC2A5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A5:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a5):
     hearing/vestibular/ear  no phenotypic analysis 

    SLC2A5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc2a5tm1.1Jnz for SLC2A5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC2A5 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC2A5 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Facilitative Na+-independent glucose transporters
    Facilitative Na+-independent glucose transporters0.33
    Class II GLUTs0.33
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    4Glycolysis and gluconeogenesis (short map)
    Glycolysis and Gluconeogenesis0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC2A5
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway

    1 BioSystems Pathway for SLC2A5
        Glycolysis and Gluconeogenesis

    5/8        Reactome Pathways for SLC2A5 (see all 8)
        Metabolism of carbohydrates
    Hexose transport
    Metabolism
    Facilitative Na+-independent glucose transporters
    SLC-mediated transmembrane transport


    1         Kegg Pathway  (Kegg details for SLC2A5):
        Carbohydrate digestion and absorption


    SLC2A5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for SLC2A5 (ENSP000003666414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A2ENSP000003235684STRING: ENSP00000323568
    CCL5ENSP000002932724STRING: ENSP00000293272
    RPSAENSP000003460674STRING: ENSP00000346067
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0015755fructose transport TAS1634504
    GO:0015758glucose transport TAS1695905
    GO:0044281small molecule metabolic process TAS--

    SLC2A5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC2A5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A5 (GTR5)

    10 Novoseek inferred chemical compound relationships for SLC2A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 89 155 7980458 (8), 17947353 (6), 8404647 (5), 12820898 (5) (see all 49)
    cytochalasin b 73.1 5 1634504 (1), 1397712 (1), 7980458 (1), 11718673 (1) (see all 5)
    glucose 62.4 72 8764205 (3), 1695905 (3), 8554516 (3), 7980458 (3) (see all 31)
    galactose 38.4 4 7980458 (2), 11718673 (1), 11341798 (1)
    monosaccharide 34.5 1 11804845 (1)
    glyceraldehyde 3-phosphate 20.8 4 11877642 (1), 11341798 (1)
    sodium 5.49 14 9073126 (2), 11877642 (1), 9073127 (1), 11341798 (1)
    cyclic amp 4.52 10 8037665 (4), 8554516 (2)
    oligonucleotide 0 2 8245960 (1), 7980458 (1)
    lipid 0 1 17079126 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC2A5 / GTR5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC2A5 gene (2 alternative transcripts): 
    NM_001135585.1  NM_003039.2  

    Unigene Cluster for SLC2A5:

    Solute carrier family 2 (facilitated glucose/fructose transporter), member 5
    Hs.530003  [show with all ESTs]
    Unigene Representative Sequence: NM_003039
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377424(uc010nzy.2 uc010nzz.2 uc001apo.3 uc010oaa.2)
    ENST00000487492 ENST00000377414(uc010oac.2 uc001app.4) ENST00000484798
    ENST00000474145 ENST00000479813 ENST00000486632(uc021ofv.1) ENST00000487835
    ENST00000464985 ENST00000473209 ENST00000536305 ENST00000535586
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    Additional mRNA sequence: 

    AF451839.1 AF479408.1 AK289849.1 AK290398.1 AK294368.1 AK295785.1 AK300091.1 AK300477.1 
    AK302047.1 AK302057.1 AK302137.1 BC001692.2 BC001820.2 BC035878.1 M55531.1 

    11 DOTS entries:

    DT.448954  DT.310883  DT.121388622  DT.92429282  DT.91956199  DT.92429281  DT.121388633  DT.100022645 
    DT.86853866  DT.101978310  DT.121388630 

    24/160 AceView cDNA sequences (see all 160):

    BC001692 AW137253 F34598 BX096261 AI125358 BP344468 BE267513 BI830826 
    BC035878 BE218165 BC001820 AI538194 AI796342 AW950275 AI360190 CA309754 
    CB153237 BQ010925 BG207571 AA481400 AI309058 AA194382 BX644129 AA416861 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                            -                                                               
    SP2:                                            -                                                               
    SP3:        -     -                                                                                             
    SP4:                                -     -                                                                     


    ECgene alternative splicing isoforms for SLC2A5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC2A5 expression in normal human tissues (normalized intensities)      SLC2A5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTTGTT
    SLC2A5 Expression
    About this image


    SLC2A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine   
     
     Smooth Muscle (Muscoskeletal System)
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Blood Brain Barrier (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells

    See SLC2A5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC2A5

    SOURCE GeneReport for Unigene cluster: Hs.530003

    UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
    Tissue specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose
    tissue

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC2A5 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a51 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 79.53(n)1
    83(a)1
      4 (80.97 cM)5
    564851  NM_019741.31  NP_062715.21 
     1501192835 
    chicken
    (Gallus gallus)
    Aves SLC2A51 solute carrier family 2 (facilitated glucose/fructose more 67.28(n)
    66.05(a)
      419438  XM_417596.3  XP_417596.3 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A56
    --
    (see all 4)
    Uncharacterized protein
    (see all 4)
    64(a)
    46(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    GL345066.1(223-11945)
    GL344358.1(22867-32636)
    zebrafish
    (Danio rerio)
    Actinopterygii wufc10e012 Transcribed sequence with weak similarity to protein more 74.25(n)    57042343 
    fruit fly
    (Drosophila melanogaster)
    Insecta sut13 sugar porter 34(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea H17B01.1a3 sugar transporter 37(a)
    (best of 4)
      II(1504573-1509692)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes VPS736
    YBR241C6
    Mitochondrial protein; mutation affects vacuolar p...
    Putative transporter, member of the sugar porter f...
    25(a)
    25(a)
    possible ortholog
    1 ↔ many
    VII(308713-310173)
    II(702589-704055)


    ENSEMBL Gene Tree for SLC2A5 (if available)
    TreeFam Gene Tree for SLC2A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC2A5 gene
    ENSG000002513572  SLC2A72  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    11 SIMAP similar genes for SLC2A5 using alignment to 8 protein entries:     GTR5_HUMAN (see all proteins):
    SLC2A7    SLC2A9    SLC2A11    SLC2A4    SLC2A1    SLC2A3
    SLC2A11-a    SLC2A11-c    SLC2A14    SLC2A2    SLC2A10

    SLC2A5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/886 SNPs in SLC2A5 are shown (see all 886)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452716881,2
    C--9096580(+) GCCCTC/GAAGGA 1 -- int10--------
    rs1478818881,2
    --9096609(+) AAACTA/GCCTGA 1 -- int10--------
    rs1398312971,2
    C--9096621(+) GTGGCC/TGGGCG 1 -- int10--------
    rs1136650821,2
    C,F--9096639(+) TCACAC/TCTGTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1510567451,2
    --9096640(+) CACACC/GTGTAA 1 -- int10--------
    rs66927681,2
    C,F,A--9096695(+) gagatC/Tgagac 1 -- int15Minor allele frequency- T:0.33NA WA CSA 9
    rs1498280471,2
    C--9096744(+) AATACA/GAAAAA 1 -- int10--------
    rs66778221,2
    C--9096756(+) ttagcC/Tgggcg 1 -- int1 ese30--------
    rs1891495121,2
    --9096805(+) TGAGGC/TAGGAG 1 -- int10--------
    rs1806724271,2
    C--9096886(+) CAGAGC/TGAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC2A5 (9095166 - 9148537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC2A5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv512717CNV Insertion21212237
    esv1504235CNV Insertion17803354
    esv1740239CNV Insertion17803354
    nsv831981CNV Loss17160897
    nsv462727CNV Loss19166990

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138230    OMIM disorders: --

    11 diseases for SLC2A5:    About MalaCards
    gout    choriocarcinoma    renal cell carcinoma    hypertension
    cerebritis    colon cancer    breast cancer    lung cancer
    thyroiditis    prostate cancer    prostatitis


    SLC2A5 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for SLC2A5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malabsorption 22.9 2 8941659 (2)
    cancer 4.01 1 16523487 (1), 18398011 (1)
    colon cancer 0 2 8037665 (1)
    breast cancer 0 2 8700847 (1), 16523487 (1)
    tumors 0 3 16523487 (2), 10622535 (1)

    Genetic Association Database (GAD): SLC2A5
    Human Genome Epidemiology (HuGE) Navigator: SLC2A5 (6 documents)

    Export disorders for SLC2A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC2A5 gene, integrated from 9 sources (see all 102):
    (articles sorted by number of sources associating them with SLC2A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PubMed id 8037665)1, 2, 9 Mahraoui L.... Brot-Laroche E. (1994)
    2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 9 White P.S....Brodeur G.M. (1998)
    3. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PubMed id 1695905)1, 2, 9 Kayano T.... Bell G.I. (1990)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (2002)
    8. Fructose transporter in human spermatozoa and small intestine is GLUT5. (PubMed id 1634504)1, 9 Burant C.F....Davidson N.O. (1992)
    9. Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone. (PubMed id 17251278)1, 9 Stuart C.A....Yin D. (2007)
    10. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PubMed id 12820898)1, 9 Gouyon F....Brot-Laroche E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6518 HGNC: 11010 AceView: SLC2A5 Ensembl:ENSG00000142583 euGenes: HUgn6518
    ECgene: SLC2A5 Kegg: 6518 H-InvDB: SLC2A5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC2A5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC2A5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC2A5 gene:
    Search GeneIP for patents involving SLC2A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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