Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



SLC2A5 Gene

protein-coding   GIFtS: 62
GCID: GC01M009095

Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter),...


(Previous symbol: GLUT5)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter),
Member 51 2
     Glucose Transporter-Like Protein 52
GLUT51 2 3 5     Solute Carrier Family 2, Facilitated Glucose Transporter Member 52
Glucose Transporter Type 5, Small Intestine2 3     Fructose Transporter3
GLUT-52 3     

External Ids:    HGNC: 110101   Entrez Gene: 65182   Ensembl: ENSG000001425837   OMIM: 1382305   UniProtKB: P227323   

Export aliases for SLC2A5 gene to outside databases

Previous GC identifers: GC01M008717 GC01M008908 GC01M008772 GC01M009031 GC01M009019 GC01M008246


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for SLC2A5 Gene:
SLC2A5 (solute carrier family 2 (facilitated glucose/fructose transporter), member 5) is a protein-coding gene. GO annotations related to this gene include fructose transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A5 gene promoter:
         GR   AREB6   Tal-1   Pbx1a   GR-beta   GR-alpha   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A5 promoter sequence
   Search Chromatin IP Primers for SLC2A5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.2   Ensembl cytogenetic band:  1p36.23   HGNC cytogenetic band: 1p36.2

SLC2A5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M009095:  view genomic region     (about GC identifiers)

Start:
9,095,166 bp from pter      End:
9,148,537 bp from pter
Size:
53,372 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 5  
Size: 501 amino acids; 54974 Da
Mass spectrometry: Mass=54973.98; Method=MALDI; Range=1-501; Source=PubMed:11840567;
Sequence caution: Sequence=AAB60641.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for SLC2A5:
1YG1 (3D)    
Secondary accessions: Q14770 Q5T977 Q8IVB3
Alternative splicing: 2 isoforms:  P22732-1   P22732-2   

Explore the universe of human proteins at neXtProt for SLC2A5: NX_P22732

Explore proteomics data for SLC2A5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51
  • Modification sites at PhosphoSitePlus

  • See SLC2A5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001129057.1  NP_003030.1  

    ENSEMBL proteins: 
     ENSP00000366641   ENSP00000366631   ENSP00000467039   ENSP00000464880   ENSP00000468590  
     ENSP00000465507   ENSP00000465382   ENSP00000467840   ENSP00000465285   ENSP00000440688  
     ENSP00000442744  
    Reactome Protein details: P22732

    SLC2A5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for SLC2A5
    OriGene Protein Over-expression Lysate for SLC2A5
    OriGene MassSpec for SLC2A5
    OriGene Custom Protein Services for SLC2A5
    GenScript Custom Purified and Recombinant Proteins Services for SLC2A5
    Novus Biologicals SLC2A5 Protein
    Novus Biologicals SLC2A5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC2A5 

    SLC2A5 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC2A5
    R&D Systems Antibodies for SLC2A5 (Glut5)
    OriGene Antibodies for SLC2A5
    OriGene Custom Antibody Services for SLC2A5
    Novus Biologicals SLC2A5 Antibodies
    Abcam antibodies for SLC2A5
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SLC2A5
    LSBio Antibodies in human, mouse, rat for SLC2A5

    SLC2A5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC2A5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC2A5
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for SLC2A5 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 5
    Class II transporters

    Selected InterPro protein domains (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR002442 Fru_transpt_5
     IPR020846 MFS_dom

    Graphical View of Domain Structure for InterPro Entry P22732

    ProtoNet protein and cluster: P22732

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002442 Fructose transporter (GLUT5) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR5_HUMAN, P22732
    Function: Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter
    Induction: By forskolin in Caco-2 cells

         Genatlas biochemistry entry for SLC2A5:
    solute carrier family 2,member A5,facilitated glucose transporter

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005353fructose transmembrane transporter activity IEA--
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    Find genes that share ontologies with SLC2A5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A5:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a5):
     hearing/vestibular/ear  no phenotypic analysis 

    Find genes that share phenotypes with SLC2A5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc2a5tm1.1Jnz for SLC2A5

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC2A5

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC2A5:
    hsa-mir-9-5p (MIRT021373)

    Block miRNA regulation of human, mouse, rat SLC2A5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC2A5
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC2A5
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC2A5

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC2A5 (see all 12)
    OriGene ORF clones in mouse, rat for SLC2A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC2A5 (NM_001135585)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for SLC2A5
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    GTR5_HUMAN, P22732: Apical cell membrane; Multi-pass membrane protein (By similarity). Membrane; Multi-pass
    membrane protein. Note=Localized on the apical membrane of the small intestine and the proximal tubule of the
    kidney (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0016324apical plasma membrane ISS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with SLC2A5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for SLC2A5 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Facilitative Na+-independent glucose transporters0.00
    Transmembrane transport of small molecules0.47
    Class II GLUTs0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Hexose transport0.87
    3Glycolysis and gluconeogenesis short map
    Glycolysis and Gluconeogenesis0.60
    4PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    5MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45


    Find genes that share SuperPaths with SLC2A5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A5
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway

    1 BioSystems Pathway for SLC2A5
        Glycolysis and Gluconeogenesis

    2 Reactome Pathways for SLC2A5
        Hexose transport
    Class II GLUTs


    1 Kegg Pathway  (Kegg details for SLC2A5):
        Carbohydrate digestion and absorption

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A5
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SLC2A5 (ENSP000003666414) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC2A2ENSP000003235684STRING: ENSP00000323568
    CCL5ENSP000002932724STRING: ENSP00000293272
    RPSAENSP000003460674STRING: ENSP00000346067
    SLC1A1ENSP000002623524STRING: ENSP00000262352
    SLC1A2ENSP000002783794STRING: ENSP00000278379
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0015755fructose transport TAS1634504
    GO:0015758glucose transport TAS1695905
    GO:0044281small molecule metabolic process TAS--

    Find genes that share ontologies with SLC2A5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A5 (GTR5)

    10 Novoseek inferred chemical compound relationships for SLC2A5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 89 155 7980458 (8), 17947353 (6), 8404647 (5), 12820898 (5) (see all 49)
    cytochalasin b 73.1 5 1634504 (1), 1397712 (1), 7980458 (1), 11718673 (1) (see all 5)
    glucose 62.4 72 8764205 (3), 1695905 (3), 8554516 (3), 7980458 (3) (see all 31)
    galactose 38.4 4 7980458 (2), 11718673 (1), 11341798 (1)
    monosaccharide 34.5 1 11804845 (1)
    glyceraldehyde 3-phosphate 20.8 4 11877642 (1), 11341798 (1)
    sodium 5.49 14 9073126 (2), 11877642 (1), 9073127 (1), 11341798 (1)
    cyclic amp 4.52 10 8037665 (4), 8554516 (2)
    oligonucleotide 0 2 8245960 (1), 7980458 (1)
    lipid 0 1 17079126 (1)



    Find genes that share compounds with SLC2A5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for SLC2A5 gene (2 alternative transcripts): 
    NM_001135585.1  NM_003039.2  

    Unigene Cluster for SLC2A5:

    Solute carrier family 2 (facilitated glucose/fructose transporter), member 5
    Hs.530003  [show with all ESTs]
    Unigene Representative Sequence: NM_003039
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377424(uc010nzy.2 uc010nzz.2 uc001apo.3 uc010oaa.2)
    ENST00000487492 ENST00000377414(uc010oac.2 uc001app.4) ENST00000484798
    ENST00000474145 ENST00000479813 ENST00000486632(uc021ofv.1) ENST00000487835
    ENST00000464985 ENST00000473209 ENST00000536305 ENST00000535586
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat SLC2A5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate SLC2A5
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for SLC2A5
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A5
    Clone
    Products:
         
    OriGene clones in human, mouse for SLC2A5 (see all 12)
    OriGene ORF clones in mouse, rat for SLC2A5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): SLC2A5 (NM_001135585)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A5
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for SLC2A5
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A5
      QuantiTect SYBR Green Assays in human, mouse, rat SLC2A5
      QuantiFast Probe-based Assays in human, mouse, rat SLC2A5

    Additional mRNA sequence: 

    AF451839.1 AF479408.1 AK289849.1 AK290398.1 AK294368.1 AK295785.1 AK300091.1 AK300477.1 
    AK302047.1 AK302057.1 AK302137.1 BC001692.2 BC001820.2 BC035878.1 M55531.1 

    11 DOTS entries:

    DT.448954  DT.310883  DT.121388622  DT.92429282  DT.91956199  DT.92429281  DT.121388633  DT.100022645 
    DT.86853866  DT.101978310  DT.121388630 

    Selected AceView cDNA sequences (see all 160):

    BC001820 AW137253 AI796342 BE218165 BC001692 AI125358 BQ010925 BI830826 
    BE559606 CA309754 AA416861 F34598 BP344468 BM673646 AW950275 BC035878 
    AI538194 T28018 AA194382 AI309058 BX644129 AI360190 BG207571 BX096261 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A5    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:                                            -                                                               
    SP2:                                            -                                                               
    SP3:        -     -                                                                                             
    SP4:                                -     -                                                                     


    ECgene alternative splicing isoforms for SLC2A5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    SLC2A5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCATTTGTT
    SLC2A5 Expression
    About this image


    SLC2A5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Bone Marrow
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced MEL2 cells
    SLC2A5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530003

    UniProtKB/Swiss-Prot: GTR5_HUMAN, P22732
    Tissue specificity: Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose
    tissue

        Custom PCR Arrays for SLC2A5
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC2A5
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A5
    QuantiTect SYBR Green Assays in human, mouse, rat SLC2A5
    QuantiFast Probe-based Assays in human, mouse, rat SLC2A5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC2A5 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a51 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 79.53(n)1
    83(a)1
      4 (80.97 cM)5
    564851  NM_019741.31  NP_062715.21 
     1501192835 
    chicken
    (Gallus gallus)
    Aves SLC2A51 solute carrier family 2 (facilitated glucose/fructose more 66.73(n)
    64.99(a)
      419438  XM_417596.4  XP_417596.4 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A56
    solute carrier family 2 (facilitated glucose/fruct...
    64(a)
    1 ↔ 1
    GL345066.1(223-11945)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc2a51 solute carrier family 2 (facilitated glucose/fructose more 61.85(n)
    63.86(a)
      493549  NM_001008186.1  NP_001008187.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc10e012 Transcribed sequence with weak similarity to protein more 74.25(n)    57042343 


    ENSEMBL Gene Tree for SLC2A5 (if available)
    TreeFam Gene Tree for SLC2A5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for SLC2A5 gene
    ENSG000002513572  SLC2A72  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    11 SIMAP similar genes for SLC2A5 using alignment to 8 protein entries:     GTR5_HUMAN (see all proteins):
    SLC2A7    SLC2A9    SLC2A11    SLC2A4    SLC2A1    SLC2A3
    SLC2A11-a    SLC2A11-c    SLC2A14    SLC2A2    SLC2A10

    Find genes that share paralogs with SLC2A5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for SLC2A5 (see all 886)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452716881,2
    C--9096580(+) GCCCTC/GAAGGA 1 -- int10--------
    rs1478818881,2
    --9096609(+) AAACTA/GCCTGA 1 -- int10--------
    rs1398312971,2
    C--9096621(+) GTGGCC/TGGGCG 1 -- int10--------
    rs1136650821,2
    C,F--9096639(+) TCACAC/TCTGTA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1510567451,2
    --9096640(+) CACACC/GTGTAA 1 -- int10--------
    rs66927681,2
    C,F,A--9096695(+) gagatC/Tgagac 1 -- int15Minor allele frequency- T:0.33NA WA CSA 9
    rs1498280471,2
    C--9096744(+) AATACA/GAAAAA 1 -- int10--------
    rs66778221,2
    C--9096756(+) ttagcC/Tgggcg 1 -- int1 ese30--------
    rs1891495121,2
    --9096805(+) TGAGGC/TAGGAG 1 -- int10--------
    rs1806724271,2
    C--9096886(+) CAGAGC/TGAGAC 1 -- int10--------

    HapMap Linkage Disequilibrium report for SLC2A5 (9095166 - 9148537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for SLC2A5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv512717CNV Insertion21212237
    esv1504235CNV Insertion17803354
    esv1740239CNV Insertion17803354
    nsv831981CNV Loss17160897
    nsv462727CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing SLC2A5
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 138230    OMIM disorders: --


    Find genes that share disorders with SLC2A5           About GenesLikeMe

    5 Novoseek inferred disease relationships for SLC2A5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    malabsorption 22.9 2 8941659 (2)
    cancer 4.01 1 16523487 (1), 18398011 (1)
    colon cancer 0 2 8037665 (1)
    breast cancer 0 2 8700847 (1), 16523487 (1)
    tumors 0 3 16523487 (2), 10622535 (1)

    Genetic Association Database (GAD): SLC2A5
    Human Genome Epidemiology (HuGE) Navigator: SLC2A5 (6 documents)

    Export disorders for SLC2A5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for SLC2A5 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with SLC2A5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP. (PubMed id 8037665)1, 2, 9 Mahraoui L.... Brot-Laroche E. (Biochem. J. 1994)
    2. Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2. (PubMed id 9691177)1, 3, 9 White P.S....Brodeur G.M. (Cytogenet. Cell Genet. 1998)
    3. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PubMed id 1695905)1, 2, 9 Kayano T.... Bell G.I. (J. Biol. Chem. 1990)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Cluster analysis of an extensive human breast cancer cell line protein expression map database. (PubMed id 11840567)1, 2 Harris R.A....Zvelebil M.J. (Proteomics 2002)
    8. Fructose transporter in human spermatozoa and small intestine is GLUT5. (PubMed id 1634504)1, 9 Burant C.F....Davidson N.O. (J. Biol. Chem. 1992)
    9. Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone. (PubMed id 17251278)1, 9 Stuart C.A....Yin D. (Diabetes Care 2007)
    10. Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. (PubMed id 12820898)1, 9 Gouyon F....Brot-Laroche E. (Biochem. J. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6518 HGNC: 11010 AceView: SLC2A5 Ensembl:ENSG00000142583 euGenes: HUgn6518
    ECgene: SLC2A5 Kegg: 6518 H-InvDB: SLC2A5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for SLC2A5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC2A5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for SLC2A5 gene:
    Search GeneIP for patents involving SLC2A5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC2A5
     
     EMD Millipore genomic analysis products

      
     Antibodies for SLC2A5 (Glut5)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for SLC2A5 (Glut5)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for SLC2A5   OriGene RNAi products in human, mouse, rat for SLC2A5  
     OriGene qPCR primer pairs and template standards for SLC2A5   OriGene Protein Over-expression Lysate for SLC2A5  
     OriGene MassSpec something-or-other for SLC2A5   OriGene clones in human, mouse for SLC2A5  
     OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A5   OriGene Purified Protein for SLC2A5  
     OriGene ORF clones in mouse, rat for SLC2A5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for SLC2A5   OriGene Custom Protein Services for SLC2A5  

     
     
     Block miRNA regulation of human, mouse, rat SLC2A5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing SLC2A5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A5 Predesigned siRNA for gene silencing in human, mouse, rat SLC2A5
     QuantiFast Probe-based Assays in human, mouse, rat SLC2A5 QuantiTect SYBR Green Assays in human, mouse, rat SLC2A5
     Custom PCR Arrays for SLC2A5 Search Chromatin IP Primers for SLC2A5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A5  Search GeneGlobe Interaction Network for SLC2A5
     Regulatory tfbs in SLC2A5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for SLC2A5 GenScript cDNA clones with any tag delivered in your preferred vector for SLC2A5
     GenScript Custom Assay Services for SLC2A5 GenScript Custom overexpressing Cell Line Services for SLC2A5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for SLC2A5 (GTR5)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     SLC2A5 antibodies
     SLC2A5 proteins
     SLC2A5 lysates
     Antibodies for SLC2A5
     See all of Abcam's Antibodies, Kits and Proteins for SLC2A5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A5
     SwitchGear 3'UTR luciferase reporter plasmids for SLC2A5
     SwitchGear Promoter luciferase reporter plasmids for SLC2A5
     ThermoFisher Antibody for SLC2A5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A5
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A5
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A5
     LSBio Antibodies in human, mouse, rat for SLC2A5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for SLC2A5
      Search eBioscience for proteins for SLC2A5
      Search eBioscience for elisas for SLC2A5
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      SLC2A5 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4