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Aliases for SLC2A4 Gene

Aliases for SLC2A4 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4 2 3
  • GLUT4 3 4 6
  • Glucose Transporter Type 4, Insulin-Responsive 3 4
  • GLUT-4 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 4 3
  • Insulin-Responsive Glucose Transporter Type 4 3

External Ids for SLC2A4 Gene

Previous Symbols for SLC2A4 Gene

  • GLUT4

Summaries for SLC2A4 Gene

Entrez Gene Summary for SLC2A4 Gene

  • This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A4 Gene

SLC2A4 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 4) is a Protein Coding gene. Diseases associated with SLC2A4 include metabolic syndrome x and obesity. Among its related pathways are L1CAM interactions and Akt Signaling. GO annotations related to this gene include glucose transmembrane transporter activity and D-glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A4 Gene

  • Insulin-regulated facilitative glucose transporter

Gene Wiki entry for SLC2A4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A4 Gene

Genomics for SLC2A4 Gene

Genomic Location for SLC2A4 Gene

Start:
7,281,667 bp from pter
End:
7,288,257 bp from pter
Size:
6,591 bases
Orientation:
Plus strand

Genomic View for SLC2A4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A4 Gene

Regulatory Elements for SLC2A4 Gene

Proteins for SLC2A4 Gene

  • Protein details for SLC2A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14672-GTR4_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 4
    Protein Accession:
    P14672
    Secondary Accessions:
    • Q05BQ3
    • Q14CX2

    Protein attributes for SLC2A4 Gene

    Size:
    509 amino acids
    Molecular mass:
    54787 Da
    Quaternary structure:
    • Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1.
    Miscellaneous:
    • Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.

    Alternative splice isoforms for SLC2A4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A4 Gene

Proteomics data for SLC2A4 Gene at MOPED

Post-translational modifications for SLC2A4 Gene

Other Protein References for SLC2A4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A4 Gene

Domains for SLC2A4 Gene

Gene Families for SLC2A4 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

GTR4_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.:
    • P14672
genes like me logo Genes that share domains with SLC2A4: view

Function for SLC2A4 Gene

Molecular function for SLC2A4 Gene

GENATLAS Biochemistry: solute carrier family 2,member A4,facilitated glucose transporter,associated to susceptibility to NIDDM with a polymorphic variant
UniProtKB/Swiss-Prot Function: Insulin-regulated facilitative glucose transporter

Gene Ontology (GO) - Molecular Function for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity TAS 2649253
GO:0005515 protein binding IPI 19478182
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A4: view
genes like me logo Genes that share phenotypes with SLC2A4: view

Animal Models for SLC2A4 Gene

MGI Knock Outs for SLC2A4:

miRNA for SLC2A4 Gene

miRTarBase miRNAs that target SLC2A4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC2A4 Gene

Localization for SLC2A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A4 Gene

Cell membrane; Multi-pass membrane protein. Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A4 Gene COMPARTMENTS Subcellular localization image for SLC2A4 gene
Compartment Confidence
plasma membrane 5
endosome 2
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome --
GO:0005771 multivesicular body IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC2A4: view

Pathways for SLC2A4 Gene

genes like me logo Genes that share pathways with SLC2A4: view

Gene Ontology (GO) - Biological Process for SLC2A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0008645 hexose transport TAS --
GO:0010021 amylopectin biosynthetic process IEA --
GO:0015758 glucose transport TAS 12556481
GO:0015992 proton transport IBA --
genes like me logo Genes that share ontologies with SLC2A4: view

Compounds for SLC2A4 Gene

(1) IUPHAR Ligand for SLC2A4 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]2-deoxyglucose None None

(108) Novoseek inferred chemical compound relationships for SLC2A4 Gene

Compound -log(P) Hits PubMed IDs
glucose 90 358
2-deoxyglucose 82.7 34
phosphatidylinositol 80.2 109
iaps-forskolin 79 3
2-n-4-(1-azi-2,2,2-trifluoroethyl)benzoyl-1,3-bis(d-mannos-4-yloxy)-2-propylamine 78 1
genes like me logo Genes that share compounds with SLC2A4: view

Transcripts for SLC2A4 Gene

Unigene Clusters for SLC2A4 Gene

Solute carrier family 2 (facilitated glucose transporter), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for SLC2A4 Gene

GeneLoc Exon Structure for
SLC2A4
ECgene alternative splicing isoforms for
SLC2A4

Expression for SLC2A4 Gene

mRNA expression in normal human tissues for SLC2A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A4 Gene

This gene is overexpressed in Muscle - Skeletal (13.5), Heart - Left Ventricle (5.9), Esophagus - Muscularis (5.3), and Esophagus - Gastroesophageal Junction (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC2A4 Gene

SOURCE GeneReport for Unigene cluster for SLC2A4 Gene Hs.380691

mRNA Expression by UniProt/SwissProt for SLC2A4 Gene

P14672-GTR4_HUMAN
Tissue specificity: Skeletal and cardiac muscles; brown and white fat
genes like me logo Genes that share expressions with SLC2A4: view

Orthologs for SLC2A4 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A4 36
  • 99.61 (n)
  • 99.8 (a)
SLC2A4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A4 36
  • 89.39 (n)
  • 93.32 (a)
SLC2A4 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A4 36
  • 90.18 (n)
  • 95.87 (a)
SLC2A4 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a4 36
  • 87.88 (n)
  • 95.28 (a)
Slc2a4 16
Slc2a4 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC2A4 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A4 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a4 36
  • 87.88 (n)
  • 95.28 (a)
lizard
(Anolis carolinensis)
Reptilia SLC2A4 37
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01043017.1 37
  • 42 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Glut1 37
  • 31 (a)
OneToMany
Glut1 38
  • 51 (a)
CG7882 38
  • 34 (a)
sut3 38
  • 31 (a)
sut4 38
  • 33 (a)
sut1 38
  • 36 (a)
sut2 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea F53H8.3 37
  • 27 (a)
ManyToMany
fgt-1 37
  • 36 (a)
ManyToMany
R09B5.11 37
  • 34 (a)
ManyToMany
H17B01.1a 38
  • 39 (a)
R09B5.11 38
  • 36 (a)
H17B01.1b 38
  • 39 (a)
Y37A1A.3 38
  • 26 (a)
K08F9.1 38
  • 24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 27 (a)
ManyToMany
VPS73 37
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 37
  • 45 (a)
OneToMany
Species with no ortholog for SLC2A4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A4 Gene

ENSEMBL:
Gene Tree for SLC2A4 (if available)
TreeFam:
Gene Tree for SLC2A4 (if available)

Paralogs for SLC2A4 Gene

Selected SIMAP similar genes for SLC2A4 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with SLC2A4: view

Variants for SLC2A4 Gene

Sequence variations from dbSNP and Humsavar for SLC2A4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs5409 -- 7,280,203(+) TTGTT(C/T)ACTCT upstream-variant-2KB
rs5410 -- 7,280,480(+) ATCGA(A/G)CCTGA upstream-variant-2KB
rs5411 -- 7,280,672(+) CGAGA(A/G)ATAGT upstream-variant-2KB
rs5412 -- 7,280,727(+) CTCCA(A/G)GTGGC upstream-variant-2KB
rs5413 -- 7,281,077(+) AGGAC(A/C)AAGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC2A4 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv457659 CNV Loss 19166990
esv2665200 CNV Deletion 23128226
dgv3053n71 CNV Loss 21882294
nsv907637 CNV Loss 21882294
nsv1963 CNV Loss 18451855

Relevant External Links for SLC2A4 Gene

HapMap Linkage Disequilibrium report
SLC2A4
Human Gene Mutation Database (HGMD)
SLC2A4

Disorders for SLC2A4 Gene

(1) OMIM Diseases for SLC2A4 Gene (138190)

UniProtKB/Swiss-Prot

GTR4_HUMAN
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the bodys own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:1521731, ECO:0000269 PubMed:1756912, ECO:0000269 PubMed:1918382}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

(46) Novoseek inferred disease relationships for SLC2A4 Gene

Disease -log(P) Hits PubMed IDs
insulin resistance 85.1 133
insulin sensitivity 80.1 61
niddm 69.2 75
hyperinsulinemia 67.2 25
obesity 59 36

Relevant External Links for SLC2A4

Genetic Association Database (GAD)
SLC2A4
Human Genome Epidemiology (HuGE) Navigator
SLC2A4
genes like me logo Genes that share disorders with SLC2A4: view

Publications for SLC2A4 Gene

  1. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. (PMID: 1756912) Choi W.H. … Moller D.E. (Diabetes 1991) 3 4 23 49
  2. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. (PMID: 1918382) Kusari J. … Olefsky J.M. (J. Clin. Invest. 1991) 3 4 23
  3. Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4. (PMID: 17382906) Jeyaraj S. … Palmada M. (Biochem. Biophys. Res. Commun. 2007) 3 4 23
  4. Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome. (PMID: 18249389) Jones M.R. … Stuckey B.G. (Fertil. Steril. 2008) 3 23 49
  5. Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation. (PMID: 1397719) Buse J.B. … Bell G.I. (Diabetes 1992) 3 4 23

Products for SLC2A4 Gene

Sources for SLC2A4 Gene

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