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SLC2A4 Gene

protein-coding   GIFtS: 66
GCID: GC17P007186

Solute Carrier Family 2 (Facilitated Glucose Transporter),...


(Previous symbol: GLUT4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 41 2
GLUT41 2 3 5
Glucose Transporter Type 4, Insulin-Responsive2 3
GLUT-42 3
Insulin-Responsive Glucose Transporter Type 42
Solute Carrier Family 2, Facilitated Glucose Transporter Member 42

External Ids:    HGNC: 110091   Entrez Gene: 65172   Ensembl: ENSG000001818567   OMIM: 1381905   UniProtKB: P146723   

Export aliases for SLC2A4 gene to outside databases

Previous GC identifers: GC17P007543 GC17P007914 GC17P007127 GC17P007385 GC17P007125 GC17P007076


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A4 Gene:
This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a
protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this
integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin
stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane.
Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). (provided by
RefSeq, Jul 2008)

GeneCards Summary for SLC2A4 Gene:
SLC2A4 (solute carrier family 2 (facilitated glucose transporter), member 4) is a protein-coding gene. Diseases associated with SLC2A4 include metabolic syndrome x, and insulin resistance. GO annotations related to this gene include D-glucose transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR4_HUMAN, P14672
Function: Insulin-regulated facilitative glucose transporter

Gene Wiki entry for SLC2A4 (GLUT4) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A4 gene promoter:
         MEF-2A   PPAR-gamma1   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A4 promoter sequence
   Search Chromatin IP Primers for SLC2A4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13

SLC2A4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A4 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P007186:  view genomic region     (about GC identifiers)

Start:
7,184,986 bp from pter      End:
7,191,576 bp from pter
Size:
6,591 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GTR4_HUMAN, P14672 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 4  
Size: 509 amino acids; 54787 Da
Subunit: Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1
Miscellaneous: Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation (By similarity)
Secondary accessions: Q14CX2

Explore the universe of human proteins at neXtProt for SLC2A4: NX_P14672

Explore proteomics data for SLC2A4 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See SLC2A4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001033.1  
    ENSEMBL proteins: 
     ENSP00000320935   ENSP00000461086   ENSP00000459864   ENSP00000459056   ENSP00000396887  
    Reactome Protein details: P14672

    SLC2A4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene Protein Over-expression Lysate for SLC2A4
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    GenScript Custom Purified and Recombinant Proteins Services for SLC2A4
    Novus Biologicals SLC2A4 Proteins
    Novus Biologicals SLC2A4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC2A4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of SLC2A4
    R&D Systems Antibodies for SLC2A4 (Glut4)
    Cell Signaling Technology (CST) Antibodies for SLC2A4  (GLUT4)
    OriGene Antibodies for SLC2A4
    OriGene Custom Antibody Services for SLC2A4
    Novus Biologicals SLC2A4 Antibodies
    Abcam antibodies for SLC2A4
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for SLC2A4
    LSBio Antibodies in human, mouse, rat for SLC2A4

    SLC2A4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for SLC2A4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for SLC2A4
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 4
    Class I transporters

    Selected InterPro protein domains (see all 6):
     IPR002441 Glc_transpt_4
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom

    Graphical View of Domain Structure for InterPro Entry P14672

    ProtoNet protein and cluster: P14672

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002441 Glucose transporter type 4 (GLUT4) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR4_HUMAN, P14672
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR4_HUMAN, P14672
    Function: Insulin-regulated facilitative glucose transporter

         Genatlas biochemistry entry for SLC2A4:
    solute carrier family 2,member A4,facilitated glucose transporter,associated to susceptibility to NIDDM with a
    polymorphic variant

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity TAS2649253
    GO:0005515protein binding IPI19478182
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
    GO:0055056D-glucose transmembrane transporter activity IEA--
         
    SLC2A4 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc2a4):
     adipose tissue  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  growth/size/body 
     homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
     nervous system 

    SLC2A4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Slc2a4tm1Mch for SLC2A4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC2A4

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC2A4:
    hsa-mir-223-3p (MIRT006559), hsa-mir-335-5p (MIRT019111), hsa-mir-92a-1-5p (MIRT038921)

    Block miRNA regulation of human, mouse, rat SLC2A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC2A4 (see all 49):
    hsa-miR-3164 hsa-miR-3678-3p hsa-miR-607 hsa-miR-642a hsa-miR-302d hsa-miR-520e hsa-miR-1914* hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC2A4
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for SLC2A4

    Clone
    Products:
         
    OriGene clones in human, mouse for SLC2A4 (see all 7)
    OriGene ORF clones in mouse, rat for SLC2A4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC2A4 (NM_001042)
    Sino Biological Human cDNA Clone for SLC2A4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A4

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for SLC2A4
    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A4 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR4_HUMAN, P14672: Cell membrane; Multi-pass membrane protein (By similarity). Endomembrane system; Multi-pass
    membrane protein. Cytoplasm, perinuclear region. Note=Localizes primarily to the perinuclear region, undergoing
    continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization
    motif is critical for intracellular sequestration
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endosome2
    extracellular2
    golgi apparatus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005768endosome ----
    GO:0005771multivesicular body IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IEA--
    GO:0005905coated pit IEA--

    SLC2A4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A4 About   (see all 32)  
    See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis short map
    Glycolysis and gluconeogenesis short map 0.60
    Glycolysis and Gluconeogenesis0.60
    2Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    3Translation Insulin regulation of translation
    Regulation of lipid metabolism Insulin signaling generic cascades0.59
    Insulin signaling pathway0.32
    4Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Facilitative Na+-independent glucose transporters0.00
    5Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for SLC2A4
        Adipocytokines & Insulin Signaling

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A4 (see all 10)
        IGF1R Signaling
    Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway
    Thrombin Signaling
    AMPK Enzyme Complex Pathway

    1 Cell Signaling Technology (CST) Pathway for SLC2A4
        Glucose / Energy Metabolism

    3 GeneGo (Thomson Reuters) Pathways for SLC2A4
        Regulation of lipid metabolism Insulin signaling-generic cascades
    Glycolysis and gluconeogenesis (short map)
    Development Leptin signaling via PI3K-dependent pathway

    Selected BioSystems Pathways for SLC2A4 (see all 8)
        Adipogenesis
    Insulin Signaling
    AMPK signaling
    Type II diabetes mellitus
    Glycolysis and Gluconeogenesis


    4 Reactome Pathways for SLC2A4
        Transcriptional regulation of white adipocyte differentiation
    Facilitative Na+-independent glucose transporters
    Translocation of GLUT4 to the plasma membrane
    Glucose transport

    1 PharmGKB Pathway for SLC2A4
        Metformin Pathway, Pharmacodynamic

    4 Kegg Pathways  (Kegg details for SLC2A4):
        FoxO signaling pathway
    Insulin signaling pathway
    Adipocytokine signaling pathway
    Type II diabetes mellitus


    SLC2A4 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A4 (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC2A4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for SLC2A4 (P146722, 3 ENSP000003209354) via UniProtKB, MINT, STRING, and/or I2D (see all 707)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000231617Q9UER72, 3, ENSP000004046234MINT-18239 MINT-18241 MINT-18240 MINT-18242 I2D: score=3 STRING: ENSP00000404623
    DAXXQ9UER72, 3, ENSP000003968764MINT-18239 MINT-18241 MINT-18240 MINT-18242 I2D: score=3 STRING: ENSP00000396876 STRING: ENSP00000266000
    HIST1H3AP684313I2D: score=1 
    HIST1H3BP684313I2D: score=1 
    HIST1H3CP684313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0010021amylopectin biosynthetic process IEA--
    GO:0015758glucose transport TAS12556481
    GO:0032869cellular response to insulin stimulus IDA12556481

    SLC2A4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A4 (GTR4)

    1 IUPHAR Ligand for SLC2A4 (Glucose transporter 4)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]2-deoxyglucose
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for SLC2A4 gene (see all 108)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 90 2083 11681787 (9), 12716734 (7), 8325952 (6), 9801136 (6) (see all 99)
    2-deoxyglucose 82.7 46 11700942 (3), 18957619 (2), 11672439 (2), 8843750 (2) (see all 27)
    phosphatidylinositol 80.2 151 15166230 (10), 10559259 (5), 11598141 (5), 12808101 (3) (see all 78)
    iaps-forskolin 79 3 8865815 (2), 8034025 (1)
    2-n-4-(1-azi-2,2,2-trifluoroethyl)benzoyl-1,3-bis(d-mannos-4-yloxy)-2-propylamine 78 2 7672486 (1)
    wortmannin 75.9 46 19258741 (5), 10455135 (4), 11598141 (3), 15928020 (2) (see all 22)
    aicar 71.7 31 12716734 (4), 11509501 (4), 16105857 (3), 19188436 (2) (see all 15)
    glycogen 71 96 16770359 (5), 14507259 (4), 9375309 (3), 15864539 (3) (see all 52)
    3-o-methylglucose 69.8 15 1599406 (3), 8626697 (2), 7672486 (2), 8760081 (1) (see all 7)
    kaempferitrin 61.6 10 19146827 (5), 19326566 (1)



    SLC2A4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC2A4 gene: 
    NM_001042.2  

    Unigene Cluster for SLC2A4:

    Solute carrier family 2 (facilitated glucose transporter), member 4
    Hs.380691  [show with all ESTs]
    Unigene Representative Sequence: NM_001042
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317370(uc002gfp.3 uc010cmd.3) ENST00000572485 ENST00000571308
    ENST00000570783 ENST00000424875(uc021tpa.1)
    miRNA
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    Block miRNA regulation of human, mouse, rat SLC2A4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC2A4 (see all 49):
    hsa-miR-3164 hsa-miR-3678-3p hsa-miR-607 hsa-miR-642a hsa-miR-302d hsa-miR-520e hsa-miR-1914* hsa-miR-106a
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A4 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC2A4 (NM_001042)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A4
    Primer
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    OriGene qPCR primer pairs and template standards for SLC2A4
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A4
      QuantiTect SYBR Green Assays in human, mouse, rat SLC2A4
      QuantiFast Probe-based Assays in human, mouse, rat SLC2A4

    Additional mRNA sequence: 

    AK300899.1 AK313372.1 BC034387.1 BC069615.1 BC069621.1 BC113592.1 BC126164.1 M20747.1 

    5 DOTS entries:

    DT.409394  DT.95228304  DT.99934293  DT.403086  DT.120957951 

    Selected AceView cDNA sequences (see all 46):

    BC069621 BX092505 M20747 AI248523 CD627355 CR603611 NM_001042 AA236945 
    AI659845 AJ709200 BC069615 AA705858 CD014068 AW663922 AJ572589 CA426302 
    F34831 AW136826 AI310138 BQ775137 AA978042 AL521328 BX389357 AI765757 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                        
    SP2:                                -                                       


    ECgene alternative splicing isoforms for SLC2A4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC2A4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCTACTCA
    SLC2A4 Expression
    About this image


    SLC2A4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 7 entries
             Subcutaneous White Adipocytes Cranial Subcutaneous White Adipose
             Body Subcutaneous White Adipose
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast Multinuclear Cells Chorionic Villus
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Heart (Cardiovascular System)
    SLC2A4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.380691

    UniProtKB/Swiss-Prot: GTR4_HUMAN, P14672
    Tissue specificity: Skeletal and cardiac muscles; brown and white fat

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A4 (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Insulin Resistance in human mouse rat
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Fatty Liver in human mouse rat
              Diabetes in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC2A4 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a41 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 87.88(n)1
    95.28(a)1
      11 (42.93 cM)5
    205281  NM_009204.21  NP_033230.21 
     699425395 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A46
    solute carrier family 2 (facilitated glucose trans...
    72(a)
    1 ↔ 1
    GL344596.1(631-26377)
    zebrafish
    (Danio rerio)
    Actinopterygii 570577222   -- 74.18(n)    57057722 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut13 glucose transporter 51(a)
    (best of 6)
      61E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea H17B01.1a3 sugar transporter 39(a)
    (best of 5)
      II(1504573-1509692)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    VPS736
    Putative transporter, member of the sugar porter f...
    Mitochondrial protein; mutation affects vacuolar p...
    27(a)
    26(a)
    many ↔ many
    many ↔ many
    II(702589-704055) YBR241C
    VII(308713-310173) YGL104C


    ENSEMBL Gene Tree for SLC2A4 (if available)
    TreeFam Gene Tree for SLC2A4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A4 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A12  
    SLC2A112  
    10 SIMAP similar genes for SLC2A4 using alignment to 5 protein entries:     GTR4_HUMAN (see all proteins):
    SLC2A1    SLC2A2    SLC2A3    SLC2A14    SLC2A5    SLC2A7
    SLC2A9    SLC2A11    SLC2A11-a    SLC2A11-c

    SLC2A4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC2A4 (see all 276)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1214345811,2,,4
    C,FDiabetes mellitus, non-insulin-dependent (NIDDM)4 pathogenic17177799(+) GCTACG/ATCTCC 2 /I /V mis12Minor allele frequency- A:0.00NA EU 5875
    rs732395541,2
    C,F--7171809(+) TTCTTG/AAGACG 1 -- us2k12Minor allele frequency- A:0.14WA 120
    rs1508624821,2
    C--7171814(+) GAGACA/GGAGTC 1 -- us2k10--------
    rs1131178321,2
    C,F--7171856(+) GATCTC/TGGCTC 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
    rs1116601511,2
    C,F--7171871(+) CAACCC/TCCACC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1855762211,2
    --7172074(+) TGAGCA/CACCAG 1 -- us2k10--------
    rs26541851,2
    C,F,O,H--7172113(+) GGATTA/CGTGCA 1 -- us2k133Minor allele frequency- C:0.42EA NA NS CSA WA 3401
    rs1486955691,2
    --7172116(+) TTAGTA/GCAGCA 1 -- us2k10--------
    rs1903427111,2
    --7172181(+) TAGGCA/GTTGCC 1 -- us2k10--------
    rs99028381,2
    C,F,H--7172191(+) CCAGAA/GCAGGA 1 -- us2k1 tfbs318Minor allele frequency- N:0.00EA NA NS WA CSA 1294

    HapMap Linkage Disequilibrium report for SLC2A4 (7184986 - 7191576 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC2A4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665200CNV Deletion23128226
    esv2422288CNV Deletion17116639
    nsv907637CNV Loss21882294
    dgv3053n71CNV Loss21882294
    nsv457659CNV Loss19166990
    nsv1963CNV Loss18451855

    Human Gene Mutation Database (HGMD): SLC2A4
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138190   
    OMIM disorders: 125853  
    UniProtKB/Swiss-Prot: GTR4_HUMAN, P14672
  • Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose
    homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese
    body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance,
    hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes,
    kidneys, nerves, and blood vessels. Note=The disease may be caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for SLC2A4 (see all 61):    
    About MalaCards
    metabolic syndrome x    insulin resistance    diabetes mellitus, noninsulin-dependent    diabetes mellitus
    type 2 diabetes mellitus    glucose intolerance    acanthosis nigricans    cholera
    tetanus    polycystic ovary syndrome    obesity, association with    hypoglycemia
    hypertriglyceridemia    growth hormone deficiency    liver cirrhosis    lipodystrophy
    dilated cardiomyopathy    hyperthyroidism    obesity    hyperglycemia


    SLC2A4 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SLC2A4 gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    insulin resistance 85.1 183 17631270 (4), 1535055 (3), 11375332 (3), 16713429 (3) (see all 99)
    insulin sensitivity 80.1 75 17402423 (4), 10368369 (2), 18957617 (2), 1928336 (2) (see all 47)
    niddm 69.2 102 1918382 (5), 1535055 (4), 8325952 (4), 9137902 (4) (see all 45)
    hyperinsulinemia 67.2 35 10516134 (2), 11287353 (2), 16269413 (2), 18435821 (2) (see all 21)
    obesity 59 42 1535055 (3), 19219422 (3), 15731326 (2), 9806316 (2) (see all 27)
    impaired glucose tolerance 46.6 2 17088413 (1), 8333511 (1)
    hyperglycemia 45.1 10 14688680 (2), 18528484 (1), 9950801 (1), 17068109 (1) (see all 9)
    glucose intolerance 45 4 9950801 (1), 15063922 (1), 16187315 (1), 17448565 (1)
    polycystic ovary syndrome 38.8 5 15292352 (2), 15731326 (1), 18249389 (1)
    insulin tolerance 38.6 2 9781315 (1), 11681787 (1)

    Genetic Association Database (GAD): SLC2A4
    Human Genome Epidemiology (HuGE) Navigator: SLC2A4 (18 documents)

    Export disorders for SLC2A4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC2A4 gene, integrated from 10 sources (see all 1004):
    (articles sorted by number of sources associating them with SLC2A4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. (PubMed id 1756912)1, 2, 4, 9 Choi W.H....Moller D.E. (Diabetes 1991)
    2. Polymorphism in postinsulin receptor signaling pathway is not associated with polycystic ovary syndrome. (PubMed id 18249389)1, 4, 9 Jones M.R....Stuckey B.G. (Fertil. Steril. 2008)
    3. Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4. (PubMed id 17382906)1, 2, 9 Jeyaraj S.... Palmada M. (Biochem. Biophys. Res. Commun. 2007)
    4. Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation. (PubMed id 1397719)1, 2, 9 Buse J.B.... Bell G.I. (Diabetes 1992)
    5. Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. (PubMed id 1918382)1, 2, 9 Kusari J.... Olefsky J.M. (J. Clin. Invest. 1991)
    6. Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population. (PubMed id 20625434)1, 4 Nair A.K....Anilkumar G. (PLoS ONE 2010)
    7. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    10. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6517 HGNC: 11009 AceView: SLC2A4 Ensembl:ENSG00000181856 euGenes: HUgn6517
    ECgene: SLC2A4 Kegg: 6517 H-InvDB: SLC2A4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A4 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Glut4

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A4 gene:
    Search GeneIP for patents involving SLC2A4

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