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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC2A3 Gene

protein-coding   GIFtS: 63
GCID: GC12M008071

solute carrier family 2 (facilitated glucose transporter),...


(Previous symbol: GLUT3)
 Explore 46 diseases affiliated with
SLC2A3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for SLC2A3    

Aliases
for SLC2A3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 31 2
GLUT31 2 3 5
Glucose Transporter Type 3, Brain2 3
GLUT-32 3
Solute Carrier Family 2, Facilitated Glucose Transporter Member 32

External Ids:    HGNC: 110071   Entrez Gene: 65152   Ensembl: ENSG000000598047   OMIM: 1381705   UniProtKB: P111693   

Export aliases for SLC2A3 gene to outside databases

Previous GC identifers: GC12M007767 GC12M008219 GC12M007972 GC12M007963 GC12M007884


Summaries
for SLC2A3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
Function: Facilitative glucose transporter. Probably a neuronal glucose transporter




Genomic Views
for SLC2A3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A3 gene promoter:
         STAT5B   c-Fos   AP-1   AML1a   FOXD3   AP-4   LCR-F1   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC2A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC2A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008071:  view genomic region     (about GC identifiers)

Start:
 8,071,824 bp from pter      End:
 8,088,892 bp from pter
Size:
 17,069 bases      Orientation:
 minus strand

Proteins
for SLC2A3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 3  
Size: 496 amino acids; 53924 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R606 D3DUU6 Q6I9U2 Q9UG15

Explore the universe of human proteins at neXtProt for SLC2A3: NX_P11169

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P11169

    • SLC2A3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008862.1  
    ENSEMBL proteins: 
     ENSP00000075120   ENSP00000440750   ENSP00000441496  
    Reactome Protein details: P11169
    Human Recombinant Protein Products: 
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    Novus Biologicals SLC2A3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for SLC2A3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    SLC2A3 for ontologies           About GeneDecksing



    SLC2A3 Antibody Products: 
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    Assay Products for SLC2A3: 
    Browse Kits and Assays available from EMD Millipore
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    Uscn ELISAs and CLIAs for SLC2A3

    Protein Domains /
    Families
    for SLC2A3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    SLC2A3 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR002945 Glc_transpt_3

    Graphical View of Domain Structure for InterPro Entry P11169

    ProtoNet protein and cluster: P11169

    4 Blocks protein families:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002945 Glucose transporter type 3 (GLUT3) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter
    subfamily


    Function
    for SLC2A3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Function: Facilitative glucose transporter. Probably a neuronal glucose transporter

         Genatlas biochemistry entry for SLC2A3:
    solute carrier family 2,member A3,facilitated glucose transporter

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC2A3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC2A3 (see all 57):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-1273d hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: SLC2A3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC2A3 (see all 7)
    OriGene shRNA RFP: SLC2A3
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for SLC2A3

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----


    SLC2A3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC2A3:
     Increased S DNA content 

    Animal Models:
         Mouse knock-outs for SLC2A3: Slc2a3tm1Dksr Slc2a3tm1Stua
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Slc2a3):
     behavior/neurological  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system  reproductive system 

    SLC2A3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for SLC2A3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    		SLC-mediated transmembrane transport1.00
    		Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    		Transmembrane transport of small molecules0.50
    2Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Glucose transport0.57
    		Hexose transport0.55
    3Vitamin B5 (pantothenate) metabolism
    		Metabolism of vitamins and cofactors0.21
    		Metabolism of water-soluble vitamins and cofactors0.21
    4Facilitative Na+-independent glucose transporters
    		Facilitative Na+-independent glucose transporters1.00
    5Vitamin C (ascorbate) metabolism
    		Vitamin C (ascorbate) metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for SLC2A3
        Selected targets of CREB1

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC2A3
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway

    1 BioSystems Pathway for SLC2A3 
        Glycolysis and Gluconeogenesis

    5/11        Reactome Pathways for SLC2A3 (see all 11)
        Metabolism of carbohydrates
    Hexose transport
    Metabolism
    Facilitative Na+-independent glucose transporters
    Metabolism of vitamins and cofactors



    SLC2A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC2A3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for SLC2A3 (P111692, 3 ENSP000000751204) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64178 I2D: score=3 STRING: ENSP00000341848
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    CREB3O438893I2D: score=1 
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0015758glucose transport TAS--


    SLC2A3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for SLC2A3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC2A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A3
    10/19 Novoseek chemical compound relationships for SLC2A3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 78.1 212 17559076 (5), 11080093 (4), 7804607 (3), 1704223 (3) (see all 99)
    2-deoxyglucose 70.4 7 1420159 (2), 10336639 (2), 19646954 (1), 12960090 (1)
    cytochalasin b 69.2 4 1420159 (1), 8504756 (1), 1417839 (1)
    dehydroascorbic acid 66.2 12 16142743 (2), 15590689 (1), 14642847 (1), 19391462 (1) (see all 5)
    18f fluorodeoxyglucose 40.4 2 19536037 (2)
    ribonucleic acid 31.5 3 9253355 (1), 10199793 (1), 18371555 (1)
    betamethasone 28 5 16782269 (3), 17359461 (2)
    2,4-dinitrophenol 27.8 7 9677332 (5), 7619042 (1)
    ascorbic acid 27.1 2 12381735 (1), 10438494 (1)
    vegf 17.2 6 9724644 (2), 17611657 (2), 17651733 (1), 18371555 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC2A3 / GTR3 

    Transcripts
    for SLC2A3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for SLC2A3 gene: 
    NM_006931.2  

    Unigene Cluster for SLC2A3:

    Solute carrier family 2 (facilitated glucose transporter), member 3
    Hs.419240  [show with all ESTs]
    Unigene Representative Sequence: AB209607
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000075120(uc001qtr.3) ENST00000543435 ENST00000486749 ENST00000469295
    ENST00000479059 ENST00000490763 ENST00000495813 ENST00000544291 ENST00000544936
    ENST00000476634 ENST00000541671

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC2A3
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate SLC2A3 (see all 57):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-1273d hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmid: SLC2A3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC2A3 (see all 7)
    OriGene shRNA RFP: SLC2A3
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AB209607.1 AK074861.1 AK298673.1 AK304509.1 AK312386.1 AY034634.1 BC039196.1 CR457413.1 
    M20681.1 

    24/47 DOTS entries (see all 47):

    DT.455164  DT.100860784  DT.121143646  DT.121143691  DT.100860785  DT.121143772  DT.85100190  DT.100697253 
    DT.91650532  DT.95069469  DT.121143670  DT.121143672  DT.92012780  DT.121143630  DT.100860779  DT.121143642 
    DT.99984415  DT.121143745  DT.121143751  DT.100710420  DT.121143674  DT.85100193  DT.91691507  DT.100860781 

    24/489 AceView cDNA sequences (see all 489):

    AA171601 AA350577 AY034634 NM_153449 BI021109 AA406552 BM558108 CD672991 
    BM548719 BM561800 BU850207 AA381487 BX357715 BM556019 CN484312 BU849981 
    AI206917 BM553863 BQ898116 BP343186 N57046 BM562542 CA440927 BM802877 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                                                                                                                                                            
    SP2:                                -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP3:                                -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -           -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SLC2A3

    Expression
    for SLC2A3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC2A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCAACTTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    SLC2A3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PlacentaChorionic VillusVillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    PlacentaExtravillous Cytotrophoblast LayerExtravillous Cytotrophoblast CellsExtraembryonic Tissues, Placenta
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Definitive endoderm-like cells (A scalable, suspensi...)

    See SLC2A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC2A3

    SOURCE GeneReport for Unigene cluster: Hs.419240

    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Tissue specificity: Highly expressed in brain. Expressed in many tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC2A3: 
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC2A3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A3

    Orthologs
    for SLC2A3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC2A3 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves SLC2A31 solute carrier family 2 (facilitated glucose transporter), more 70.3(n)
    73.87(a)    		   396517  NM_205511.1  NP_990842.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 65(a)
    		 1 → many
    		 GL343236.1(1404410-1419907)
    zebrafish
    (Danio rerio)    		 Actinopterygii slc2a3a1 solute carrier family 2 (facilitated glucose transporter), more 64.79(n)
    67.6(a)    		   436916  NM_001002643.1  NP_001002643.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Glut11 , 3 glucose transporter3
    Glucose transporter 11    		 50(a)
    (best of 5)3
    53.95(n)1
    49.69(a)1    		   61E13
    381091  NM_001103999.31  NP_001097469.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea H17B01.1a3
    fgt-11    		 sugar transporter3
    Protein FGT-11    		 43(a)
    (best of 6)3
    50.58(n)1
    43.91(a)1    		   II(1504573-1509692)3
    1735251  NM_061580.31  NP_493981.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PGLCT1 Plastidic glucose transporter 4 46.97(n)
    35.63(a)    		   831472  NM_121620.2  NP_568328.1 
    rice
    (Oryza sativa)    		 Liliopsida Os01g01334001 hypothetical protein 45.29(n)
    33.56(a)    		   4325804  NM_001048473.1  NP_001041938.1 


    ENSEMBL Gene Tree for SLC2A3 (if available)
    TreeFam Gene Tree for SLC2A3 (if available) 

    Paralogs
    for SLC2A3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC2A3 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    11 SIMAP similar genes for SLC2A3 using alignment to 3 protein entries:     GTR3_HUMAN (see all proteins):
    SLC2A14    SLC2A1    SLC2A2    SLC2A4    SLC2A5    SLC2A9
    SLC2A7    SLC2A11    SLC2A11-a    SLC2A11-c    SLC2A8

    SLC2A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC2A3
    PGOHUM00000244056 PGOHUM00000249736


    Genomic Variants
    for SLC2A3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/458 NCBI SNPs in SLC2A3 are shown (see all 458)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2016459051,2
    		--8071342(+) TTTTC-/TTTTGA 1 -- ds50010--------
    rs1811650551,2
    		--8071350(+) TGAGAC/TGGAGT 1 -- ds50010--------
    rs1379748621,2
    		C,--8071394(+) GCGAT-/CCTCTG 1 -- ds50010--------
    rs2010152791,2
    		--8071400(+) TCTGC-/GGAG  
                TCACC     		1 -- ds50010--------
    rs1857526731,2
    		--8071406(+) TCACCA/GCAACC 1 -- ds50010--------
    rs1407343161,2
    		--8071418(+) CCGCCA/TCCCAG 1 -- ds50010--------
    rs1501623821,2
    		--8071478(+) GAATGC/GGCCAT 1 -- ds50010--------
    rs1903735751,2
    		--8071600(+) GCTGGA/GATTAC 1 -- ds50010--------
    rs1404302331,2
    		--8071624(+) CGCGCC/TTGGCC 1 -- ds50010--------
    rs797047311,2
    		C,F,--8071625(+) GCGCCT/CGGCCA 1 -- ds50013Minor allele frequency- C:0.19WA CSA 122

    HapMap Linkage Disequilibrium report for SLC2A3 (8071824 - 8088892 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 40 variations for SLC2A3
         15/40 CNVs (see all 40): 53688 9682 34502 53537 49138 37682 75923 5305 5304 49140 34464 34642 53992 49137 2968

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    Disorders / Diseases
    for SLC2A3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    SLC2A3 for disorders           About GeneDecksing

    OMIM gene information: 138170    OMIM disorders: --

    20/46 diseases for SLC2A3 (see all 46):    About MalaCards
    b-cell non-hodgkin lymphoma    diffuse large b-cell lymphoma    non-hodgkin lymphoma    acanthosis nigricans
    fetal macrosomia    fibrous histiocytoma    non-small cell lung carcinoma    b-cell lymphomas
    malignant fibrous histiocytoma    islet cell tumor    hodgkin's lymphoma    insulin resistance
    histiocytoma    anorexia nervosa    diabetes mellitus    hypoglycemia
    lung carcinoma    squamous cell carcinoma    choriocarcinoma    hyperglycemia

    10/29 Novoseek disease relationships for SLC2A3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 45 4 9766571 (2), 9179927 (1), 10657852 (1)
    nsclc stage i 43.2 3 9305704 (2), 11551404 (1)
    insulin resistance 22.9 3 11436180 (2), 10070142 (1)
    tumors 22.8 38 9305704 (3), 8314336 (3), 10025844 (3), 16730088 (3) (see all 20)
    diabetes gestational 22.2 1 10086067 (1)
    hyperglycemia 21.3 7 11080093 (3), 9766571 (2), 10070142 (2)
    meningioma 14.7 3 8265814 (1), 1617673 (1)
    hypoglycemia 14.4 6 11080093 (3), 10070142 (2)
    hyperinsulinemia 14.4 1 7559581 (1)
    cancer 13.3 8 18422279 (2), 2372287 (2), 9252709 (1), 9305704 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: SLC2A3 (4 documents)

    Export disorders for SLC2A3 gene to outside databases

    Publications
    for SLC2A3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC2A3 gene, integrated from 9 sources (see all 201):
    (articles sorted by number of sources associating them with SLC2A3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site. (PubMed id 9477959)1, 2 Seatter M.J.... Gould G.W. (1998)
    3. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. (PubMed id 3170580)1, 2 Kayano T....Bell G.I. (1988)
    4. Regenerating human muscle fibres express GLUT3 protein. (PubMed id 12397394)1, 9 Gaster M....Schroder H.D. (2002)
    5. IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1. (PubMed id 17920708)1, 9 Copland J.A....Stuart C.A. (2007)
    6. Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75. (PubMed id 17559076)1, 9 Meneses A.M....Owen G.I. (2008)
    7. Distribution of GLUT3 glucose transporter protein in human tissues. (PubMed id 1417839)1, 9 Shepherd P.R....Kahn B.B. (1992)
    8. Glucose transporter (Glut1, Glut3) mRNA in human placenta of diabetic and non-diabetic pregnancies. (PubMed id 10086067)1, 9 Sciullo E....Fallucca F. (1997)
    9. IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism. (PubMed id 18299470)1, 9 Dimitriadis G....Hadjidakis D.J. (2008)
    10. Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. (PubMed id 18764953)1, 9 Parente P....Bigotti G. (2008)

    External Searches for SLC2A3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing SLC2A3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6515 HGNC: 11007 AceView: SLC2A3andSLC2A14 Ensembl:ENSG00000059804 euGenes: HUgn6515
    ECgene: SLC2A3 H-InvDB: SLC2A3

    Other Databases showing SLC2A3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing SLC2A3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC2A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC2A3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for SLC2A3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for SLC2A3 gene:
    Search GeneIP for patents involving SLC2A3

    GeneCards and IP:
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