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Aliases & Descriptions for SLC2A3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ90380 2 | | GLUT-3 3 | | GLUT3 2, 3, 5 |
| | | Descriptions |
|---|
| Glucose transporter type 3, brain 2, 3 | solute carrier family 2 (facilitated glucose transporter), member 3 2 |
|
| | Search outside databases for aliases for SLC2A3 genePrevious GC identifers: GC12M007767 GC12M008219 GC12M007972 |
Summaries for SLC2A3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169Function: Facilitative glucose transporter. Probably a neuronal glucose transporter |
Genomic Location for SLC2A3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the SLC2A3 gene 
Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.3SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M007963:
(about GC identifiers)
Start:
|
7,963,094 bp from pter |
End:
|
7,982,246 bp from pter |
Size:
|
19,153 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009714.16
| Proteins for SLC2A3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169 (See
protein sequence)Recommended Name: Solute carrier family 2, facilitated glucose transporter member 3 Size: 496 amino acids; 53924 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q6I9U2 Q9UG15Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_008862.1
ENSEMBL proteins: ENSP00000075120 ENSP00000379829
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for SLC2A3: Assays for SLC2A3: | Protein
Domains/ Families for SLC2A3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11169
ProtoNet protein and cluster: P11169 4 Blocks protein families: IPB000803 Mammalian facilitated glucose transporter family signature IPB002945 Glucose transporter type 3 (GLUT3) signature IPB003663 Sugar transporter signature IPB005829 Sugar transporter superfamily
UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily | Gene Function for SLC2A3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006931
Applied Biosystems Silencer® siRNAs for SLC2A3
Sigma-Aldrich siRNA and siRNA Panels for SLC2A3  Sigma-Aldrich shRNA for SLC2A3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006931                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006931                                  untagged cDNA clone in CMV expression vector: NM_006931 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006931
UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169Function: Facilitative glucose transporter. Probably a neuronal glucose transporterGenatlas biochemistry entry for SLC2A3:solute carrier family 2,member A3,facilitated glucose transporter8 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Slc2a3):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005215 | transporter activity |
IEA | -- | | GO:0005351 | sugar:hydrogen symporter activity |
IEA | -- | | GO:0005355 | glucose transmembrane transporter activity |
TAS | 1695905 | | GO:0022891 | substrate-specific transmembrane transporter activity |
IEA | -- | About this table | Pathways & Interactions for SLC2A3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for SLC2A3 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for SLC2A3 
2 Interacting proteins for SLC2A3 (P111692 ENSP000000751203) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for SLC2A3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for SLC2A3 10 Novoseek chemical compound relationships for SLC2A3 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| glucose |
78.13 |
206 |
17559076 (5), 11080093 (4), 7804607 (3), 1704223 (3) (see all 99) |
| cytochalasin b |
68.25 |
4 |
1420159 (1), 8504756 (1), 1417839 (1) |
| ribonucleic acid |
32.48 |
3 |
9253355 (1), 10199793 (1), 18371555 (1) |
| glycogen |
12.42 |
3 |
11719595 (1), 12375681 (1) |
| oxygen |
0.00 |
4 |
16136514 (2), 16142743 (1), 17442736 (1) |
| sodium |
0.00 |
1 |
12381735 (1) |
| nitric oxide |
0.00 |
2 |
15320870 (1), 9724644 (1) |
| progesterone |
0.00 |
4 |
12960090 (2), 12915684 (1) |
| ethanol |
0.00 |
4 |
8022421 (2), 8749801 (1) |
| tyrosine |
0.00 |
1 |
9724644 (1) |
About this table
|
Transcripts for SLC2A3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006931
Sigma-Aldrich siRNA and siRNA Panels for SLC2A3  Sigma-Aldrich shRNA for SLC2A3  Explore Sigma-Aldrich super-pooled esiRNAs 
REFSEQ mRNAs for SLC2A3 gene: NM_006931.2               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006931                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006931                                  untagged cDNA clone in CMV expression vector: NM_006931  Additional cDNA sequence: AB209607.1 AK074861.1 AK298673.1 AK304509.1 AK312386.1 AY034634.1 BC039196.1 CR457413.1 CR621471.1 M20681.1 24/47 DOTS entries (see all 47
): DT.455164 DT.100860784 DT.121143646 DT.121143691 DT.100860785 DT.121143772 DT.85100190 DT.100697253 DT.91650532 DT.95069469 DT.121143670 DT.121143672 DT.92012780 DT.121143630 DT.100860779 DT.121143642 DT.99984415 DT.121143674 DT.40114333 DT.121143745 DT.121143751 DT.100710420 DT.121143699 DT.85100193 24/489 AceView cDNA sequences (see all 489
):CD672991 NM_153449 AL702725 BM556019 BI021109 CD656442 AA171601 BQ898116 BU849981 AY034634 BM802877 AU185976 BQ441087 BM561800 BM548719 CD644645 AA406552 BM476335 BM926950 BU071967 BM706092 CN484312 BQ718375 CB267921
highest scoring ESTs for SLC2A3:M20681 AA101336 AA171601 AA181409 AA181612 AA181772 AA204807 AA205794 AA216668 AA218573 Unigene Cluster for SLC2A3: Solute carrier family 2 (facilitated glucose transporter), member 3 Hs.419240 [show with all ESTs]Unigene Representative Sequence: AB209607
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 (see all 9
)
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for SLC2A3
2 Ensembl transcripts including schematic representations: ENST00000075120
ENST00000396584
|
Expression for SLC2A3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| SLC2A3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for SLC2A3
1 / 2 / 3 11 probe-sets matching SLC2A3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCAACTTCTG
SOURCE GeneReport for Unigene cluster: Hs.419240
Expression variation in blood from EXPOLDB for SLC2A3 UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169Tissue specificity: Highly expressed in brain. Expressed in many tissues |
Orthologs for SLC2A3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for SLC2A3 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for SLC2A3
ENSEMBL Gene Tree for SLC2A3 | Paralogs for SLC2A3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for SLC2A3 gene
- SLC2A142 SLC2A22 SLC2A42 SLC2A12
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for SLC2A3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for SLC2A3 (up to first 250kb)
|
Disorders & Mutations for SLC2A3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 138170
10/29 Novoseek disease relationships for SLC2A3 gene (see all 29
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| choriocarcinoma |
46.25 |
4 |
9766571 (2), 9179927 (1), 10657852 (1) |
| nsclc stage i |
45.39 |
3 |
9305704 (2), 11551404 (1) |
| diabetes gestational |
24.36 |
1 |
10086067 (1) |
| hyperglycemia |
23.38 |
7 |
11080093 (3), 9766571 (2), 10070142 (2) |
| insulin resistance |
20.99 |
3 |
11436180 (2), 10070142 (1) |
| tumors |
20.41 |
36 |
9305704 (3), 8314336 (3), 10025844 (3), 16730088 (3) (see all 19) |
| hypoglycemia |
16.35 |
6 |
11080093 (3), 10070142 (2) |
| meningioma |
16.28 |
3 |
8265814 (1), 1617673 (1) |
| hyperinsulinemia |
15.76 |
1 |
7559581 (1) |
| nsclc |
13.45 |
5 |
9305704 (2), 11551404 (2), 18422279 (1) |
About this table
|
Medical News for SLC2A3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for SLC2A3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/168 PubMed articles for SLC2A3 gene (see all 168
):- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site. (PubMed id 9477959)3, 4 Seatter M.J.... Gould G.W. (1998)
- Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. (PubMed id 3170580)3, 4 Kayano T....Bell G.I. (1988)
- Regenerating human muscle fibres express GLUT3 protein. (PubMed id 12397394)1, 3 Gaster M....Schroder H.D. (2002)
- IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1. (PubMed id 17920708)1, 3 Copland J.A....Stuart C.A. (2007)
- Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75. (PubMed id 17559076)1, 3 Meneses A.M....Owen G.I. (2008)
- Distribution of GLUT3 glucose transporter protein in human tissues. (PubMed id 1417839)1, 3 Shepherd P.R....Kahn B.B. (1992)
- Glucose transporter (Glut1, Glut3) mRNA in human placenta of diabetic and non-diabetic pregnancies. (PubMed id 10086067)1, 3 Sciullo E....Fallucca F. (1997)
- IGF-I increases the recruitment of GLUT4 and GLUT3 glucose transporters on cell surface in hyperthyroidism. (PubMed id 18299470)1, 3 Dimitriadis G....Hadjidakis D.J. (2008)
- Immunohistochemical expression of the glucose transporters Glut-1 and Glut-3 in human malignant melanomas and benign melanocytic lesions. (PubMed id 18764953)1, 3 Parente P....Bigotti G. (2008)
|
Search for SLC2A3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing SLC2A3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing SLC2A3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing SLC2A3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for SLC2A3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for SLC2A3:

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Incremental update: 13 Oct 2009
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