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Aliases for SLC2A3 Gene

Aliases for SLC2A3 Gene

  • Solute Carrier Family 2 Member 3 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 2 3
  • Glucose Transporter Type 3, Brain 3 4
  • GLUT-3 3 4
  • GLUT3 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 3 3

External Ids for SLC2A3 Gene

Previous HGNC Symbols for SLC2A3 Gene

  • GLUT3

Previous GeneCards Identifiers for SLC2A3 Gene

  • GC12M007767
  • GC12M008219
  • GC12M007972
  • GC12M007963
  • GC12M008071
  • GC12M007884

Summaries for SLC2A3 Gene

GeneCards Summary for SLC2A3 Gene

SLC2A3 (Solute Carrier Family 2 Member 3) is a Protein Coding gene. Diseases associated with SLC2A3 include Huntington Disease and Xanthogranulomatous Cholecystitis. Among its related pathways are Metabolism and Immune System. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A14.

UniProtKB/Swiss-Prot for SLC2A3 Gene

  • Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A3 Gene

Genomics for SLC2A3 Gene

Regulatory Elements for SLC2A3 Gene

Enhancers for SLC2A3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F007968 1.2 FANTOM5 Ensembl ENCODE 21.1 -34.9 -34905 4.8 HDGF ATF1 PKNOX1 CREB3L1 SIN3A FEZF1 GLI4 ETS1 ZNF121 GLIS2 SLC2A3 NECAP1 CLEC4A SLC2A14 FOXJ2 CLEC6A C3AR1 GC12P007976
GH12F007834 1.2 FANTOM5 Ensembl ENCODE 17.4 +101.1 101126 1.3 ESRRA SAP130 CEBPG ZNF644 ZNF121 CTBP1 GATA3 RFX1 L3MBTL2 SP5 SLC2A3 FOXJ2 NANOGP1 SLC2A14 ENSG00000255356 DPPA3 CLEC4A NECAP1 GC12M007850 ENSG00000201663
GH12F007958 1.1 FANTOM5 Ensembl ENCODE 13.1 -24.5 -24505 5.6 PKNOX1 ATF1 WRNIP1 ARID4B SIN3A ZNF2 GATA2 SP3 SP5 NCOA1 SLC2A3 HADHAP2 NECAP1 CLEC4A FOXJ2 GC12P007976
GH12F007825 0.7 FANTOM5 ENCODE 10.7 +110.2 110202 1.5 ZNF366 ZNF512 PRDM1 DPPA3 ENSG00000201549 NECAP1 SLC2A3 NANOG GC12P007808 GC12M007850 ENSG00000201663
GH12F007832 0.5 Ensembl ENCODE 10.2 +103.8 103830 0.7 HDAC1 CTCF ZNF654 PKNOX1 ARID4B ZEB2 EBF1 RAD21 ZNF518A ZBTB48 DPPA3 SLC2A3 GC12M007850 ENSG00000201663 GC12P007808
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC2A3 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001774709 1296 3601 PKNOX1 ATF1 ARID4B ZNF2 YY1 ZNF121 ZNF143 DEK PAF1 SP5

Genomic Location for SLC2A3 Gene

Chromosome:
12
Start:
7,919,228 bp from pter
End:
7,936,296 bp from pter
Size:
17,069 bases
Orientation:
Minus strand

Genomic View for SLC2A3 Gene

Genes around SLC2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A3 Gene

Proteins for SLC2A3 Gene

  • Protein details for SLC2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11169-GTR3_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
    Protein Accession:
    P11169
    Secondary Accessions:
    • B2R606
    • D3DUU6
    • Q6I9U2
    • Q9UG15

    Protein attributes for SLC2A3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53924 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLC2A3 Gene

neXtProt entry for SLC2A3 Gene

Post-translational modifications for SLC2A3 Gene

Other Protein References for SLC2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A3 Gene

Domains & Families for SLC2A3 Gene

Gene Families for SLC2A3 Gene

Suggested Antigen Peptide Sequences for SLC2A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11169

UniProtKB/Swiss-Prot:

GTR3_HUMAN :
  • Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Domain:
  • Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A3: view

Function for SLC2A3 Gene

Molecular function for SLC2A3 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A3,facilitated glucose transporter
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

Gene Ontology (GO) - Molecular Function for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005355 glucose transmembrane transporter activity IEA,IDA 26176916
GO:0005536 glucose binding IDA 26176916
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
GO:0033300 dehydroascorbic acid transporter activity EXP 9228080
genes like me logo Genes that share ontologies with SLC2A3: view
genes like me logo Genes that share phenotypes with SLC2A3: view

Human Phenotype Ontology for SLC2A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC2A3 Gene

MGI Knock Outs for SLC2A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC2A3 Gene

Localization for SLC2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A3 Gene COMPARTMENTS Subcellular localization image for SLC2A3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IMP 9477959
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 26176916
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLC2A3: view

Pathways & Interactions for SLC2A3 Gene

genes like me logo Genes that share pathways with SLC2A3: view

Pathways by source for SLC2A3 Gene

Interacting Proteins for SLC2A3 Gene

Gene Ontology (GO) - Biological Process for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process NAS 1695905
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0015758 glucose transport TAS --
GO:0019852 L-ascorbic acid metabolic process TAS --
genes like me logo Genes that share ontologies with SLC2A3: view

No data available for SIGNOR curated interactions for SLC2A3 Gene

Drugs & Compounds for SLC2A3 Gene

(13) Drugs for SLC2A3 Gene - From: DGIdb, IUPHAR, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]2-deoxyglucose Pharma 0
Glufosfamide Pharma inhibitor 0

(8) Additional Compounds for SLC2A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A3: view

Transcripts for SLC2A3 Gene

Unigene Clusters for SLC2A3 Gene

Solute carrier family 2 (facilitated glucose transporter), member 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2: - - - - - - - - - - - - - - -
SP3: -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - -
SP9:

Relevant External Links for SLC2A3 Gene

GeneLoc Exon Structure for
SLC2A3
ECgene alternative splicing isoforms for
SLC2A3

Expression for SLC2A3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for SLC2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A3 Gene

This gene is overexpressed in Whole Blood (x28.1).

Protein differential expression in normal tissues from HIPED for SLC2A3 Gene

This gene is overexpressed in Platelet (47.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC2A3 Gene



Protein tissue co-expression partners for SLC2A3 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A3 Gene:

SLC2A3

SOURCE GeneReport for Unigene cluster for SLC2A3 Gene:

Hs.419240

mRNA Expression by UniProt/SwissProt for SLC2A3 Gene:

P11169-GTR3_HUMAN
Tissue specificity: Highly expressed in brain. Expressed in many tissues.
genes like me logo Genes that share expression patterns with SLC2A3: view

Primer Products

Orthologs for SLC2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A3 34 35
  • 99.4 (n)
dog
(Canis familiaris)
Mammalia SLC2A3 34 35
  • 85.16 (n)
cow
(Bos Taurus)
Mammalia SLC2A3 34 35
  • 83.03 (n)
mouse
(Mus musculus)
Mammalia Slc2a3 34 16 35
  • 80.89 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909595 34
  • 80.49 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves SLC2A3 34 35
  • 70.3 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497763 34
  • 65.49 (n)
zebrafish
(Danio rerio)
Actinopterygii slc2a3a 34 35
  • 63.38 (n)
slc2a3b 35
  • 55 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Glut1 36 34 35
  • 54.07 (n)
sut1 36
  • 38 (a)
CG7882 36
  • 35 (a)
sut2 36
  • 33 (a)
sut3 36
  • 31 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007340 34
  • 53.42 (n)
worm
(Caenorhabditis elegans)
Secernentea fgt-1 34 35
  • 51.42 (n)
H17B01.1a 36
  • 43 (a)
H17B01.1b 36
  • 43 (a)
R09B5.11 36 35
  • 38 (a)
F53H8.3 36 35
  • 31 (a)
C35A11.4 36
  • 27 (a)
K08F9.1 36
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBR241C 34
  • 44.04 (n)
-- 35
  • 27 (a)
ManyToMany
VPS73 35
  • 25 (a)
ManyToMany
STL1 37
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06853g 34
  • 43.23 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGLCT 34
  • 47.62 (n)
rice
(Oryza sativa)
Liliopsida Os01g0133400 34
  • 45.52 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07169 34
  • 45.92 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 35
  • 44 (a)
OneToMany
Species where no ortholog for SLC2A3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A3 Gene

ENSEMBL:
Gene Tree for SLC2A3 (if available)
TreeFam:
Gene Tree for SLC2A3 (if available)

Paralogs for SLC2A3 Gene

(10) SIMAP similar genes for SLC2A3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC2A3 Gene

genes like me logo Genes that share paralogs with SLC2A3: view

Variants for SLC2A3 Gene

Sequence variations from dbSNP and Humsavar for SLC2A3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1060744 -- 7,928,766(-) TCTCA(A/G)ATTTC intron-variant
rs10772855 -- 7,928,323(+) AACCC(A/G)GGAGG intron-variant
rs11056505 -- 7,926,219(+) CCTGA(A/G)TAGCT intron-variant
rs11056506 -- 7,926,222(+) GAGTA(A/G)CTGGA intron-variant
rs11056509 -- 7,926,785(+) GAGGT(G/T)GGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A3 Gene

Variant ID Type Subtype PubMed ID
dgv11e213 CNV gain 24956385
dgv1351n100 CNV gain 25217958
dgv1352n100 CNV gain 25217958
dgv1353n100 CNV gain 25217958
dgv1354n100 CNV gain 25217958
dgv1355n100 CNV gain+loss 25217958
dgv1356n100 CNV gain 25217958
dgv1357n100 CNV loss 25217958
dgv166e201 CNV deletion 23290073
dgv167e201 CNV deletion 23290073
dgv179n27 CNV gain 19166990
dgv180n27 CNV gain 19166990
dgv182n27 CNV loss 19166990
dgv183n27 CNV loss 19166990
dgv2328n54 CNV gain 21841781
dgv2329n54 CNV gain 21841781
dgv2331n54 CNV gain 21841781
dgv2332n54 CNV gain+loss 21841781
dgv2333n54 CNV loss 21841781
dgv2334n54 CNV loss 21841781
dgv2335n54 CNV loss 21841781
dgv2336n54 CNV loss 21841781
dgv2337n54 CNV gain 21841781
dgv2338n54 CNV loss 21841781
dgv449e212 CNV gain 25503493
dgv57e55 CNV gain 17911159
dgv58e55 CNV gain 17911159
dgv59e55 CNV gain 17911159
dgv5e196 CNV duplication 17116639
dgv60e55 CNV loss 17911159
dgv61n111 CNV duplication 26073780
dgv6e196 CNV duplication 17116639
esv2422117 CNV duplication 20811451
esv2751114 CNV loss 17911159
esv2751118 CNV gain 17911159
esv2759877 CNV gain+loss 17122850
esv2760250 CNV gain 21179565
esv2761054 CNV gain+loss 21179565
esv29743 CNV gain 19812545
esv34016 CNV loss 18971310
esv3548706 CNV deletion 23714750
esv3548709 CNV deletion 23714750
esv3580097 CNV loss 25503493
esv3580549 CNV gain 25503493
esv3628444 CNV loss 21293372
esv3628445 CNV gain 21293372
esv3628448 CNV loss 21293372
esv3628449 CNV loss 21293372
esv3628450 CNV gain 21293372
esv3892129 CNV gain+loss 25118596
esv3892130 CNV gain+loss 25118596
esv3892132 CNV gain 25118596
nsv428270 CNV gain 18775914
nsv442253 CNV gain 18776908
nsv469100 CNV gain 19166990
nsv470264 CNV gain 18288195
nsv470265 CNV loss 18288195
nsv516107 CNV gain+loss 19592680
nsv557298 CNV gain 21841781
nsv557328 CNV loss 21841781
nsv557331 CNV gain 21841781
nsv818884 CNV gain 17921354
nsv826225 CNV gain 20364138
nsv983269 CNV duplication 23825009

Variation tolerance for SLC2A3 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A3 Gene

Human Gene Mutation Database (HGMD)
SLC2A3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A3 Gene

Disorders for SLC2A3 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC2A3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
xanthogranulomatous cholecystitis
  • cx
krukenberg carcinoma
  • krukenberg neoplasm
early onset absence epilepsy
fetal macrosomia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A3

Genetic Association Database (GAD)
SLC2A3
Human Genome Epidemiology (HuGE) Navigator
SLC2A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A3
genes like me logo Genes that share disorders with SLC2A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A3 Gene

Publications for SLC2A3 Gene

  1. Molecular basis of ligand recognition and transport by glucose transporters. (PMID: 26176916) Deng D. … Yan N. (Nature 2015) 3 4 64
  2. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PMID: 19786962) Roeske D. … Schulte-KAPrne G. (Mol. Psychiatry 2011) 3 46 64
  3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K. … Hosoya T. (Nephron Clin Pract 2010) 3 46 64
  4. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  5. GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. (PMID: 20428049) Ayala F.R. … Soares F.A. (Molecules 2010) 3 22 64

Products for SLC2A3 Gene

Sources for SLC2A3 Gene

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