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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC2A3 Gene

protein-coding   GIFtS: 65
GCID: GC12M008071

Solute Carrier Family 2 (Facilitated Glucose Transporter),...


(Previous symbol: GLUT3)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 31 2
GLUT31 2 3 5
Glucose Transporter Type 3, Brain2 3
GLUT-32 3
Solute Carrier Family 2, Facilitated Glucose Transporter Member 32

External Ids:    HGNC: 110071   Entrez Gene: 65152   Ensembl: ENSG000000598047   OMIM: 1381705   UniProtKB: P111693   

Export aliases for SLC2A3 gene to outside databases

Previous GC identifers: GC12M007767 GC12M008219 GC12M007972 GC12M007963 GC12M007884


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for SLC2A3 Gene: 
SLC2A3 (solute carrier family 2 (facilitated glucose transporter), member 3) is a protein-coding gene. Diseases associated with SLC2A3 include fetal macrosomia, and acanthosis nigricans, and among its related super-pathways are Transmembrane transport of small molecules and Glucose transport. GO annotations related to this gene include glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
Function: Facilitative glucose transporter. Probably a neuronal glucose transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A3 gene promoter:
         STAT5B   c-Fos   AP-1   AML1a   FOXD3   AP-4   LCR-F1   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC2A3 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC2A3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008071:  view genomic region     (about GC identifiers)

Start:
8,071,824 bp from pter      End:
8,088,892 bp from pter
Size:
17,069 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 3  
Size: 496 amino acids; 53924 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: B2R606 D3DUU6 Q6I9U2 Q9UG15

Explore the universe of human proteins at neXtProt for SLC2A3: NX_P11169

Explore proteomics data for SLC2A3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11169

  • SLC2A3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC2A3 Protein Expression
    REFSEQ proteins: NP_008862.1  
    ENSEMBL proteins: 
     ENSP00000075120   ENSP00000440750   ENSP00000441496  
    Reactome Protein details: P11169
    Human Recombinant Protein Products for SLC2A3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SLC2A3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC2A3 for ontologies           About GeneDecksing



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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 3 
    Class I transporters

    5/6 InterPro protein domains (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR002945 Glc_transpt_3

    Graphical View of Domain Structure for InterPro Entry P11169

    ProtoNet protein and cluster: P11169

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002945 Glucose transporter type 3 (GLUT3) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR3_HUMAN, P11169
    Function: Facilitative glucose transporter. Probably a neuronal glucose transporter

         Genatlas biochemistry entry for SLC2A3:
    solute carrier family 2,member A3,facilitated glucose transporter

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0005542folic acid binding ----
    GO:0008518reduced folate carrier activity ----
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    SLC2A3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A3:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc2a3):
     behavior/neurological  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     nervous system  reproductive system 

    SLC2A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC2A3: Slc2a3tm1Dksr Slc2a3tm1Stua

       inGenious Targeting Laboratory - Custom generated mouse model solutions for SLC2A3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A3 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC2A3 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87
    3Metabolism of vitamins and cofactors
    Metabolism of water-soluble vitamins and cofactors1.00
    Metabolism of vitamins and cofactors1.00
    4Glycolysis and gluconeogenesis (short map)
    Glycolysis and Gluconeogenesis0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for SLC2A3
        Selected targets of CREB1

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC2A3
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway

    1 BioSystems Pathway for SLC2A3
        Glycolysis and Gluconeogenesis

    5/11        Reactome Pathways for SLC2A3 (see all 11)
        Metabolism of carbohydrates
    Hexose transport
    Metabolism
    Facilitative Na+-independent glucose transporters
    Metabolism of vitamins and cofactors



    SLC2A3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for SLC2A3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for SLC2A3 (P111692, 3 ENSP000000751204) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64178 I2D: score=3 STRING: ENSP00000341848
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    CREB3O438893I2D: score=1 
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006810transport ----
    GO:0008645hexose transport TAS--

    SLC2A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC2A3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A3 (GTR3)

    1 IUPHAR Ligand for SLC2A3 (Glucose transporter 3)    About this table 
    LigandTypeActionAffinityPubmed IDs
    [3H]2-deoxyglucose
    NoneNone--

    10/19 Novoseek inferred chemical compound relationships for SLC2A3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 78.1 212 17559076 (5), 11080093 (4), 7804607 (3), 1704223 (3) (see all 99)
    2-deoxyglucose 70.4 7 1420159 (2), 10336639 (2), 19646954 (1), 12960090 (1)
    cytochalasin b 69.2 4 1420159 (1), 8504756 (1), 1417839 (1)
    dehydroascorbic acid 66.2 12 16142743 (2), 15590689 (1), 14642847 (1), 19391462 (1) (see all 5)
    18f fluorodeoxyglucose 40.4 2 19536037 (2)
    ribonucleic acid 31.5 3 9253355 (1), 10199793 (1), 18371555 (1)
    betamethasone 28 5 16782269 (3), 17359461 (2)
    2,4-dinitrophenol 27.8 7 9677332 (5), 7619042 (1)
    ascorbic acid 27.1 2 12381735 (1), 10438494 (1)
    vegf 17.2 6 9724644 (2), 17611657 (2), 17651733 (1), 18371555 (1)

    Search CenterWatch for drugs/clinical trials and news about SLC2A3 / GTR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC2A3 gene: 
    NM_006931.2  

    Unigene Cluster for SLC2A3:

    Solute carrier family 2 (facilitated glucose transporter), member 3
    Hs.419240  [show with all ESTs]
    Unigene Representative Sequence: AB209607
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000075120(uc001qtr.3) ENST00000543435 ENST00000486749 ENST00000469295
    ENST00000479059 ENST00000490763 ENST00000495813 ENST00000544291 ENST00000544936
    ENST00000476634 ENST00000541671

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    Additional mRNA sequence: 

    AB209607.1 AK074861.1 AK298673.1 AK304509.1 AK312386.1 AY034634.1 BC039196.1 CR457413.1 
    M20681.1 

    24/47 DOTS entries (see all 47):

    DT.455164  DT.100860784  DT.121143646  DT.121143691  DT.100860785  DT.121143772  DT.85100190  DT.100697253 
    DT.91650532  DT.95069469  DT.121143670  DT.121143672  DT.92012780  DT.121143630  DT.100860779  DT.121143642 
    DT.99984415  DT.121143745  DT.121143751  DT.100710420  DT.121143674  DT.85100193  DT.91691507  DT.100860781 

    24/489 AceView cDNA sequences (see all 489):

    BM553863 BU850207 BX357715 AA381487 BM558108 BM548719 BM556019 AY034634 
    BI021109 AA171601 BM561800 NM_153449 AA350577 BP343186 N57046 CA440927 
    AL702725 BU071967 BM802877 BM926950 BM561608 CR621471 BM476335 T29744 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                                                                                                                                                            
    SP2:                                -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP3:                                -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -           -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SLC2A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC2A3 expression in normal human tissues (normalized intensities)      SLC2A3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACTTCTG
    SLC2A3 Expression
    About this image


    SLC2A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/16 selected tissues (see all 16) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             T Helper Cells Thymus
             bone marrow mononuclear cells   
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Villous Cytotrophoblast Cells Chorionic Villus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Peripheral Nervous System (Nervous System)
             PERIPHERAL NERVOUS SYSTEM   

    See SLC2A3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC2A3

    SOURCE GeneReport for Unigene cluster: Hs.419240

    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Tissue specificity: Highly expressed in brain. Expressed in many tissues

        SABiosciences Expression via Pathway-Focused PCR Arrays including SLC2A3: 
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC2A3 gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a31 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 80.83(n)1
    83.54(a)1
      6 (57.82 cM)5
    205271  NM_011401.41  NP_035531.31 
     1227278095 
    chicken
    (Gallus gallus)
    Aves SLC2A31 solute carrier family 2 (facilitated glucose transporter), more 70.3(n)
    73.87(a)
      396517  NM_205511.1  NP_990842.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    68(a)
    1 → many
    GL343236.1(1391723-1422178)
    zebrafish
    (Danio rerio)
    Actinopterygii slc2a3a1 solute carrier family 2 (facilitated glucose transporter), more 64.79(n)
    67.6(a)
      436916  NM_001002643.1  NP_001002643.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut11 , 3 glucose transporter3
    Glucose transporter 11
    50(a)
    (best of 5)3
    53.95(n)1
    49.69(a)1
      61E13
    381091  NM_001103999.31  NP_001097469.21 
    worm
    (Caenorhabditis elegans)
    Secernentea H17B01.1a3
    fgt-11
    sugar transporter3
    Protein FGT-11
    43(a)
    (best of 6)3
    50.58(n)1
    43.91(a)1
      II(1504573-1509692)3
    1735251  NM_061580.31  NP_493981.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PGLCT1 Plastidic glucose transporter 4 46.97(n)
    35.63(a)
      831472  NM_121620.2  NP_568328.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01334001 hypothetical protein 45.29(n)
    33.56(a)
      4325804  NM_001048473.1  NP_001041938.1 


    ENSEMBL Gene Tree for SLC2A3 (if available)
    TreeFam Gene Tree for SLC2A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC2A3 gene
    ENSG000002513572  SLC2A72  SLC2A52  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    10 SIMAP similar genes for SLC2A3 using alignment to 3 protein entries:     GTR3_HUMAN (see all proteins):
    SLC2A14    SLC2A1    SLC2A2    SLC2A4    SLC2A5    SLC2A9
    SLC2A7    SLC2A11    SLC2A11-a    SLC2A11-c

    SLC2A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC2A3
    PGOHUM00000244056 PGOHUM00000249736


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/562 SNPs in SLC2A3 are shown (see all 562)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016459051,2
    C--8071342(+) GTTTT-/TTTTGA 1 -- ds50010--------
    rs1811650551,2
    --8071350(+) TGAGAC/TGGAGT 1 -- ds50010--------
    rs1379748621,2
    C--8071394(+) GCGAT-/CCTCTG 1 -- ds50010--------
    rs2010152791,2
    --8071400(+) TCTGC-/GGAG  
            
    TCACC
    1 -- ds50010--------
    rs1857526731,2
    --8071406(+) TCACCA/GCAACC 1 -- ds50010--------
    rs1407343161,2
    --8071418(+) CCGCCA/TCCCAG 1 -- ds50010--------
    rs1501623821,2
    C--8071478(+) GAATGC/GGCCAT 1 -- ds50010--------
    rs1903735751,2
    --8071600(+) GCTGGA/GATTAC 1 -- ds50010--------
    rs1404302331,2
    --8071624(+) CGCGCC/TTGGCC 1 -- ds50010--------
    rs797047311,2
    C,F--8071625(+) GCGCCT/CGGCCA 1 -- ds50013Minor allele frequency- C:0.19WA CSA 122

    HapMap Linkage Disequilibrium report for SLC2A3 (8071824 - 8088892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/43 variations for SLC2A3 (see all 43):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv186e201CNV Deletion23290073
    dgv185e201CNV Deletion23290073
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639
    esv2422117CNV Duplication20811451
    dgv183n27CNV Loss19166990
    dgv60e55CNV Loss17911159
    dgv182n27CNV Loss19166990
    dgv1355n71CNV Loss21882294
    dgv1362n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 138170    OMIM disorders: --

    20/41 diseases for SLC2A3 (see all 41):    About MalaCards
    fetal macrosomia    acanthosis nigricans    islet cell tumor    choriocarcinoma
    hyperglycemia    hypoglycemia    histiocytoma    fibrous histiocytoma
    hodgkin's lymphoma    hyperthyroidism    non-hodgkin lymphoma    laryngeal carcinoma
    meningioma    non-small cell lung carcinoma    anorexia nervosa    hypoxia
    diffuse large b-cell lymphoma    insulin resistance    hyperparathyroidism    laryngitis


    SLC2A3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/29 Novoseek inferred disease relationships for SLC2A3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 45 4 9766571 (2), 9179927 (1), 10657852 (1)
    nsclc stage i 43.2 3 9305704 (2), 11551404 (1)
    insulin resistance 22.9 3 11436180 (2), 10070142 (1)
    tumors 22.8 38 9305704 (3), 8314336 (3), 10025844 (3), 16730088 (3) (see all 20)
    diabetes gestational 22.2 1 10086067 (1)
    hyperglycemia 21.3 7 11080093 (3), 9766571 (2), 10070142 (2)
    meningioma 14.7 3 8265814 (1), 1617673 (1)
    hypoglycemia 14.4 6 11080093 (3), 10070142 (2)
    hyperinsulinemia 14.4 1 7559581 (1)
    cancer 13.3 8 18422279 (2), 2372287 (2), 9252709 (1), 9305704 (1) (see all 5)

    Genetic Association Database (GAD): SLC2A3
    Human Genome Epidemiology (HuGE) Navigator: SLC2A3 (4 documents)

    Export disorders for SLC2A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC2A3 gene, integrated from 9 sources (see all 207):
    (articles sorted by number of sources associating them with SLC2A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
    2. L-type voltage-dependent calcium channel alpha subuni t 1C is a novel candidate gene associated with secondary hyperparathyroidism: a n application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (2010)
    3. First genome-wide association scan on neurophysiologi cal endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic chi ldren. (PubMed id 19786962)1, 4 Roeske D....Schulte-KAPrne G. (2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site. (PubMed id 9477959)1, 2 Seatter M.J.... Gould G.W. (1998)
    6. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. (PubMed id 3170580)1, 2 Kayano T....Bell G.I. (1988)
    7. Regenerating human muscle fibres express GLUT3 protein. (PubMed id 12397394)1, 9 Gaster M....Schroder H.D. (2002)
    8. IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1. (PubMed id 17920708)1, 9 Copland J.A....Stuart C.A. (2007)
    9. Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75. (PubMed id 17559076)1, 9 Meneses A.M....Owen G.I. (2008)
    10. Distribution of GLUT3 glucose transporter protein in human tissues. (PubMed id 1417839)1, 9 Shepherd P.R....Kahn B.B. (1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6515 HGNC: 11007 AceView: SLC2A3andSLC2A14 Ensembl:ENSG00000059804 euGenes: HUgn6515
    ECgene: SLC2A3 H-InvDB: SLC2A3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC2A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC2A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for SLC2A3 gene:
    Search GeneIP for patents involving SLC2A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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