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Aliases for SLC2A3 Gene

Aliases for SLC2A3 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 2 3
  • GLUT3 3 4 6
  • Glucose Transporter Type 3, Brain 3 4
  • GLUT-3 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 3 3

External Ids for SLC2A3 Gene

Previous Symbols for SLC2A3 Gene

  • GLUT3

Summaries for SLC2A3 Gene

GeneCards Summary for SLC2A3 Gene

SLC2A3 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3) is a Protein Coding gene. Diseases associated with SLC2A3 include huntington disease and fetal macrosomia. Among its related pathways are Disease and PAK Pathway. GO annotations related to this gene include glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A3 Gene

  • Facilitative glucose transporter. Probably a neuronal glucose transporter

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A3 Gene

Genomics for SLC2A3 Gene

Genomic Location for SLC2A3 Gene

Start:
7,919,228 bp from pter
End:
7,936,296 bp from pter
Size:
17,069 bases
Orientation:
Minus strand

Genomic View for SLC2A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A3 Gene

Regulatory Elements for SLC2A3 Gene

Proteins for SLC2A3 Gene

  • Protein details for SLC2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11169-GTR3_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
    Protein Accession:
    P11169
    Secondary Accessions:
    • B2R606
    • D3DUU6
    • Q6I9U2
    • Q9UG15

    Protein attributes for SLC2A3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53924 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC2A3 Gene

Proteomics data for SLC2A3 Gene at MOPED

Post-translational modifications for SLC2A3 Gene

Other Protein References for SLC2A3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A3 Gene

Domains for SLC2A3 Gene

Gene Families for SLC2A3 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

UniProtKB/Swiss-Prot:

GTR3_HUMAN
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.:
    • P11169
genes like me logo Genes that share domains with SLC2A3: view

Function for SLC2A3 Gene

Molecular function for SLC2A3 Gene

GENATLAS Biochemistry: solute carrier family 2,member A3,facilitated glucose transporter
UniProtKB/Swiss-Prot Function: Facilitative glucose transporter. Probably a neuronal glucose transporter

Gene Ontology (GO) - Molecular Function for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IEA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A3: view
genes like me logo Genes that share phenotypes with SLC2A3: view

Animal Models for SLC2A3 Gene

MGI Knock Outs for SLC2A3:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SLC2A3 Gene

Localization for SLC2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A3 Gene COMPARTMENTS Subcellular localization image for SLC2A3 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with SLC2A3: view

Pathways for SLC2A3 Gene

SuperPathways for SLC2A3 Gene

Superpath Contained pathways
1 Defective BTD causes biotidinase deficiency
2 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
3 Regulation of Glucokinase by Glucokinase Regulatory Protein
4 Disease
5 PAK Pathway
genes like me logo Genes that share pathways with SLC2A3: view

Pathways by source for SLC2A3 Gene

Interacting Proteins for SLC2A3 Gene

Gene Ontology (GO) - Biological Process for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0006766 vitamin metabolic process TAS --
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0006810 transport --
GO:0008645 hexose transport TAS --
genes like me logo Genes that share ontologies with SLC2A3: view

Compounds for SLC2A3 Gene

(1) IUPHAR Ligand for SLC2A3 Gene

Ligand Type Action Affinity Pubmed IDs
[3H]2-deoxyglucose None None

(19) Novoseek inferred chemical compound relationships for SLC2A3 Gene

Compound -log(P) Hits PubMed IDs
glucose 78.1 148
2-deoxyglucose 70.4 6
cytochalasin b 69.2 3
dehydroascorbic acid 66.2 6
18f fluorodeoxyglucose 40.4 2
genes like me logo Genes that share compounds with SLC2A3: view

Transcripts for SLC2A3 Gene

Unigene Clusters for SLC2A3 Gene

Solute carrier family 2 (facilitated glucose transporter), member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2: - - - - - - - - - - - - - - -
SP3: -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - -
SP9:

Relevant External Links for SLC2A3 Gene

GeneLoc Exon Structure for
SLC2A3
ECgene alternative splicing isoforms for
SLC2A3

Expression for SLC2A3 Gene

mRNA expression in normal human tissues for SLC2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A3 Gene

This gene is overexpressed in Whole Blood (28.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A3 Gene

SOURCE GeneReport for Unigene cluster for SLC2A3 Gene Hs.419240

mRNA Expression by UniProt/SwissProt for SLC2A3 Gene

P11169-GTR3_HUMAN
Tissue specificity: Highly expressed in brain. Expressed in many tissues.
genes like me logo Genes that share expressions with SLC2A3: view

Orthologs for SLC2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A3 36
  • 99.4 (n)
  • 99.6 (a)
SLC2A3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A3 36
  • 83.03 (n)
  • 86 (a)
SLC2A3 37
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC2A3 36
  • 85.16 (n)
  • 88.26 (a)
SLC2A3 37
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Slc2a3 36
  • 80.89 (n)
  • 83.54 (a)
Slc2a3 16
Slc2a3 37
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100909595 36
  • 80.49 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves SLC2A3 36
  • 70.3 (n)
  • 73.87 (a)
SLC2A3 37
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497763 36
  • 65.49 (n)
  • 68.32 (a)
zebrafish
(Danio rerio)
Actinopterygii slc2a3a 36
  • 63.38 (n)
  • 65.09 (a)
slc2a3a 37
  • 58 (a)
ManyToMany
slc2a3b 37
  • 55 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007340 36
  • 53.42 (n)
  • 50.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glut1 36
  • 54.07 (n)
  • 49.89 (a)
Glut1 37
  • 29 (a)
OneToMany
Glut1 38
  • 50 (a)
CG7882 38
  • 35 (a)
sut3 38
  • 31 (a)
sut1 38
  • 38 (a)
sut2 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea F53H8.3 37
  • 25 (a)
ManyToMany
fgt-1 36
  • 51.42 (n)
  • 44.86 (a)
fgt-1 37
  • 38 (a)
ManyToMany
R09B5.11 37
  • 35 (a)
ManyToMany
H17B01.1a 38
  • 43 (a)
R09B5.11 38
  • 38 (a)
H17B01.1b 38
  • 43 (a)
K08F9.1 38
  • 27 (a)
C35A11.4 38
  • 27 (a)
F53H8.3 38
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 27 (a)
ManyToMany
STL1 39
VPS73 37
  • 25 (a)
ManyToMany
YBR241C 36
  • 44.04 (n)
  • 30.32 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06853g 36
  • 43.23 (n)
  • 30.13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGLCT 36
  • 47.62 (n)
  • 35.94 (a)
rice
(Oryza sativa)
Liliopsida Os01g0133400 36
  • 45.52 (n)
  • 34.26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07169 36
  • 45.92 (n)
  • 31.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 37
  • 44 (a)
OneToMany
Species with no ortholog for SLC2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A3 Gene

ENSEMBL:
Gene Tree for SLC2A3 (if available)
TreeFam:
Gene Tree for SLC2A3 (if available)

Paralogs for SLC2A3 Gene

Selected SIMAP similar genes for SLC2A3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC2A3 Gene

genes like me logo Genes that share paralogs with SLC2A3: view

Variants for SLC2A3 Gene

Sequence variations from dbSNP and Humsavar for SLC2A3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs12842 -- 7,919,412(+) ACACT(C/T)GATAG utr-variant-3-prime
rs25684 -- 7,921,596(-) TTCAC(C/T)GGCTT reference, synonymous-codon
rs741361 -- 7,923,089(+) TTCCC(A/G)GAAGC intron-variant
rs933552 -- 7,938,107(-) ATTCC(G/T)CCTCC upstream-variant-2KB
rs1060744 -- 7,928,766(-) TCTCA(A/G)ATTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A3 Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv456e1 CNV Complex 17122850
dgv457e1 CNV Complex 17122850
nsv516107 CNV Gain+Loss 19592680
dgv58e55 CNV Gain 17911159
essv10974 CNV CNV 17122850
esv34016 CNV Loss 18971310
esv2751114 CNV Loss 17911159
dgv1355n71 CNV Loss 21882294
dgv179n27 CNV Gain 19166990
dgv1357n71 CNV Gain 21882294
dgv185e201 CNV Deletion 23290073
nsv470264 CNV Gain 18288195
dgv1359n71 CNV Gain 21882294
dgv1360n71 CNV Gain 21882294
dgv1361n71 CNV Gain+Loss 21882294
nsv470265 CNV Loss 18288195
dgv180n27 CNV Gain 19166990
dgv186e201 CNV Deletion 23290073
esv29743 CNV Gain 19812545
dgv182n27 CNV Loss 19166990
nsv818884 CNV Gain 17921354
esv2422117 CNV Duplication 20811451
dgv183n27 CNV Loss 19166990
nsv826225 CNV Gain 20364138
dgv1362n71 CNV Loss 21882294
nsv442253 CNV CNV 18776908
dgv59e55 CNV Gain 17911159
esv2751118 CNV Gain 17911159
essv22724 CNV CNV 17122850
dgv60e55 CNV Loss 17911159
dgv458e1 CNV Complex 17122850
nsv469100 CNV Gain 19166990
dgv1363n71 CNV Gain 21882294
essv23467 CNV CNV 17122850
dgv1364n71 CNV Gain 21882294
nsv898729 CNV Gain 21882294
nsv898731 CNV Gain 21882294

Relevant External Links for SLC2A3 Gene

HapMap Linkage Disequilibrium report
SLC2A3
Human Gene Mutation Database (HGMD)
SLC2A3

Disorders for SLC2A3 Gene

(29) Novoseek inferred disease relationships for SLC2A3 Gene

Disease -log(P) Hits PubMed IDs
choriocarcinoma 45 4
nsclc stage i 43.2 3
insulin resistance 22.9 3
tumors 22.8 33
diabetes gestational 22.2 1

Relevant External Links for SLC2A3

Genetic Association Database (GAD)
SLC2A3
Human Genome Epidemiology (HuGE) Navigator
SLC2A3
genes like me logo Genes that share disorders with SLC2A3: view

No data available for UniProtKB/Swiss-Prot for SLC2A3 Gene

Publications for SLC2A3 Gene

  1. Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6). (PMID: 1695905) Kayano T. … Bell G.I. (J. Biol. Chem. 1990) 3 23
  2. The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types. (PMID: 9253355) Hauguel-de Mouzon S. … Girard J. (J. Clin. Endocrinol. Metab. 1997) 3 23
  3. Glucose transporter (Glut1, Glut3) mRNA in human placenta of diabetic and non-diabetic pregnancies. (PMID: 10086067) Sciullo E. … Fallucca F. (Early Pregnancy 1997) 3 23
  4. Distribution of GLUT3 glucose transporter protein in human tissues. (PMID: 1417839) Shepherd P.R. … Kahn B.B. (Biochem. Biophys. Res. Commun. 1992) 3 23
  5. Human articular chondrocytes express three facilitative glucose transporter isoforms: GLUT1, GLUT3 and GLUT9. (PMID: 11991658) Mobasheri A. … Carter S.D. (Cell Biol. Int. 2002) 3 23

Products for SLC2A3 Gene

Sources for SLC2A3 Gene

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