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Aliases for SLC2A3 Gene

Aliases for SLC2A3 Gene

  • Solute Carrier Family 2 Member 3 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 2 3 5
  • Glucose Transporter Type 3, Brain 3 4
  • GLUT-3 3 4
  • GLUT3 3 4

External Ids for SLC2A3 Gene

Previous HGNC Symbols for SLC2A3 Gene

  • GLUT3

Previous GeneCards Identifiers for SLC2A3 Gene

  • GC12M007767
  • GC12M008219
  • GC12M007972
  • GC12M007963
  • GC12M008071
  • GC12M007884

Summaries for SLC2A3 Gene

GeneCards Summary for SLC2A3 Gene

SLC2A3 (Solute Carrier Family 2 Member 3) is a Protein Coding gene. Diseases associated with SLC2A3 include huntington disease and fetal macrosomia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A3 Gene

  • Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A3 Gene

Genomics for SLC2A3 Gene

Regulatory Elements for SLC2A3 Gene

Promoters for SLC2A3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC2A3 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A3 Gene

Chromosome:
12
Start:
7,919,228 bp from pter
End:
7,936,296 bp from pter
Size:
17,069 bases
Orientation:
Minus strand

Genomic View for SLC2A3 Gene

Genes around SLC2A3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A3 Gene

Proteins for SLC2A3 Gene

  • Protein details for SLC2A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11169-GTR3_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 3
    Protein Accession:
    P11169
    Secondary Accessions:
    • B2R606
    • D3DUU6
    • Q6I9U2
    • Q9UG15

    Protein attributes for SLC2A3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53924 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for SLC2A3 Gene

neXtProt entry for SLC2A3 Gene

Proteomics data for SLC2A3 Gene at MOPED

Post-translational modifications for SLC2A3 Gene

Other Protein References for SLC2A3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SLC2A3 Gene

Domains & Families for SLC2A3 Gene

Gene Families for SLC2A3 Gene

Suggested Antigen Peptide Sequences for SLC2A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11169

UniProtKB/Swiss-Prot:

GTR3_HUMAN :
  • Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Domain:
  • Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A3: view

Function for SLC2A3 Gene

Molecular function for SLC2A3 Gene

GENATLAS Biochemistry:
solute carrier family 2,member A3,facilitated glucose transporter
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

Gene Ontology (GO) - Molecular Function for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033300 dehydroascorbic acid transporter activity EXP 9228080
GO:0055056 D-glucose transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with SLC2A3: view
genes like me logo Genes that share phenotypes with SLC2A3: view

Human Phenotype Ontology for SLC2A3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC2A3 Gene

MGI Knock Outs for SLC2A3:

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A3

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC2A3 Gene

Localization for SLC2A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A3 Gene COMPARTMENTS Subcellular localization image for SLC2A3 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SLC2A3: view

Pathways & Interactions for SLC2A3 Gene

genes like me logo Genes that share pathways with SLC2A3: view

Pathways by source for SLC2A3 Gene

Interacting Proteins for SLC2A3 Gene

Gene Ontology (GO) - Biological Process for SLC2A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006767 water-soluble vitamin metabolic process TAS --
GO:0008645 hexose transport TAS --
GO:0015758 glucose transport TAS --
GO:0044281 small molecule metabolic process TAS --
GO:0070837 dehydroascorbic acid transport EXP 9228080
genes like me logo Genes that share ontologies with SLC2A3: view

No data available for SIGNOR curated interactions for SLC2A3 Gene

Drugs & Compounds for SLC2A3 Gene

(11) Drugs for SLC2A3 Gene - From: Novoseek, IUPHAR, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
[<sup>3</sup>H]2-deoxyglucose Pharma 0
Glufosfamide Pharma inhibitor 0

(10) Additional Compounds for SLC2A3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A3: view

Transcripts for SLC2A3 Gene

Unigene Clusters for SLC2A3 Gene

Solute carrier family 2 (facilitated glucose transporter), member 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2: - - - - - - - - - - - - - - -
SP3: -
SP4:
SP5: - - - - - - - - - - - - - - -
SP6: -
SP7:
SP8: - - -
SP9:

Relevant External Links for SLC2A3 Gene

GeneLoc Exon Structure for
SLC2A3
ECgene alternative splicing isoforms for
SLC2A3

Expression for SLC2A3 Gene

mRNA expression in normal human tissues for SLC2A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A3 Gene

This gene is overexpressed in Whole Blood (x28.1).

Protein differential expression in normal tissues from HIPED for SLC2A3 Gene

This gene is overexpressed in Platelet (47.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A3 Gene



SOURCE GeneReport for Unigene cluster for SLC2A3 Gene Hs.419240

mRNA Expression by UniProt/SwissProt for SLC2A3 Gene

P11169-GTR3_HUMAN
Tissue specificity: Highly expressed in brain. Expressed in many tissues.
genes like me logo Genes that share expression patterns with SLC2A3: view

Protein tissue co-expression partners for SLC2A3 Gene

Primer Products

In Situ Assay Products

Orthologs for SLC2A3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A3 36
  • 100 (a)
OneToOne
SLC2A3 35
  • 99.4 (n)
  • 99.6 (a)
cow
(Bos Taurus)
Mammalia SLC2A3 35
  • 83.03 (n)
  • 86 (a)
SLC2A3 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia SLC2A3 36
  • 88 (a)
OneToMany
SLC2A3 35
  • 85.16 (n)
  • 88.26 (a)
mouse
(Mus musculus)
Mammalia Slc2a3 16
Slc2a3 36
  • 83 (a)
OneToMany
Slc2a3 35
  • 80.89 (n)
  • 83.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100909595 35
  • 80.49 (n)
  • 83.33 (a)
chicken
(Gallus gallus)
Aves SLC2A3 35
  • 70.3 (n)
  • 73.87 (a)
SLC2A3 36
  • 72 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497763 35
  • 65.49 (n)
  • 68.32 (a)
zebrafish
(Danio rerio)
Actinopterygii slc2a3a 36
  • 58 (a)
ManyToMany
slc2a3b 36
  • 55 (a)
ManyToMany
slc2a3a 35
  • 63.38 (n)
  • 65.09 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007340 35
  • 53.42 (n)
  • 50.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7882 37
  • 35 (a)
Glut1 37
  • 50 (a)
sut1 37
  • 38 (a)
sut2 37
  • 33 (a)
sut3 37
  • 31 (a)
Glut1 35
  • 54.07 (n)
  • 49.89 (a)
Glut1 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C35A11.4 37
  • 27 (a)
F53H8.3 37
  • 31 (a)
H17B01.1a 37
  • 43 (a)
H17B01.1b 37
  • 43 (a)
K08F9.1 37
  • 27 (a)
R09B5.11 37
  • 38 (a)
fgt-1 35
  • 51.42 (n)
  • 44.86 (a)
F53H8.3 36
  • 25 (a)
ManyToMany
fgt-1 36
  • 38 (a)
ManyToMany
R09B5.11 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YBR241C 35
  • 44.04 (n)
  • 30.32 (a)
-- 36
  • 27 (a)
ManyToMany
VPS73 36
  • 25 (a)
ManyToMany
STL1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F06853g 35
  • 43.23 (n)
  • 30.13 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PGLCT 35
  • 47.62 (n)
  • 35.94 (a)
rice
(Oryza sativa)
Liliopsida Os01g0133400 35
  • 45.52 (n)
  • 34.26 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07169 35
  • 45.92 (n)
  • 31.46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 36
  • 44 (a)
OneToMany
Species with no ortholog for SLC2A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A3 Gene

ENSEMBL:
Gene Tree for SLC2A3 (if available)
TreeFam:
Gene Tree for SLC2A3 (if available)

Paralogs for SLC2A3 Gene

(10) SIMAP similar genes for SLC2A3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC2A3 Gene

genes like me logo Genes that share paralogs with SLC2A3: view

Variants for SLC2A3 Gene

Sequence variations from dbSNP and Humsavar for SLC2A3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17728193 - 7,933,003(+) GTTGA(C/G/T)GAAGA reference, missense
rs25684 -- 7,921,596(-) TTCAC(C/T)GGCTT reference, synonymous-codon
rs2377238 -- 7,923,838(+) atctc(A/G/T)actta intron-variant
rs3831762 -- 7,935,113(+) TGTGA(-/C)CCACC intron-variant
rs3216511 -- 7,928,832(+) CCAAG(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A3 Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv456e1 CNV Complex 17122850
dgv457e1 CNV Complex 17122850
nsv516107 CNV Gain+Loss 19592680
dgv58e55 CNV Gain 17911159
essv10974 CNV CNV 17122850
esv34016 CNV Loss 18971310
esv2751114 CNV Loss 17911159
dgv1355n71 CNV Loss 21882294
dgv179n27 CNV Gain 19166990
dgv1357n71 CNV Gain 21882294
dgv185e201 CNV Deletion 23290073
nsv470264 CNV Gain 18288195
dgv1359n71 CNV Gain 21882294
dgv1360n71 CNV Gain 21882294
dgv1361n71 CNV Gain+Loss 21882294
nsv470265 CNV Loss 18288195
dgv180n27 CNV Gain 19166990
dgv186e201 CNV Deletion 23290073
esv29743 CNV Gain 19812545
dgv182n27 CNV Loss 19166990
nsv818884 CNV Gain 17921354
esv2422117 CNV Duplication 20811451
dgv183n27 CNV Loss 19166990
nsv826225 CNV Gain 20364138
dgv1362n71 CNV Loss 21882294
nsv442253 CNV CNV 18776908
dgv59e55 CNV Gain 17911159
esv2751118 CNV Gain 17911159
essv22724 CNV CNV 17122850
dgv60e55 CNV Loss 17911159
dgv458e1 CNV Complex 17122850
nsv469100 CNV Gain 19166990
dgv1363n71 CNV Gain 21882294
essv23467 CNV CNV 17122850
dgv1364n71 CNV Gain 21882294
nsv898729 CNV Gain 21882294
nsv898731 CNV Gain 21882294

Variation tolerance for SLC2A3 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A3 Gene

HapMap Linkage Disequilibrium report
SLC2A3
Human Gene Mutation Database (HGMD)
SLC2A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A3 Gene

Disorders for SLC2A3 Gene

MalaCards: The human disease database

(7) MalaCards diseases for SLC2A3 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
fetal macrosomia
acanthosis nigricans
  • an - acanthosis nigricans
early onset absence epilepsy
xanthogranulomatous cholecystitis
  • cx
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC2A3

Genetic Association Database (GAD)
SLC2A3
Human Genome Epidemiology (HuGE) Navigator
SLC2A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A3
genes like me logo Genes that share disorders with SLC2A3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A3 Gene

Publications for SLC2A3 Gene

  1. Molecular basis of ligand recognition and transport by glucose transporters. (PMID: 26176916) Deng D. … Yan N. (Nature 2015) 3 4 67
  2. GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. (PMID: 20428049) Ayala F.R. … Soares F.A. (Molecules 2010) 3 23
  3. Glut1 and Glut3 expression in lymphoma and their association with tumor intensity on 18F-fluorodeoxyglucose positron emission tomography. (PMID: 19536037) Khandani A.H. … Shea T.C. (Nucl Med Commun 2009) 3 23
  4. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. (PMID: 19554504) Fonteyne P. … Van de Wiele C. (Histol. Histopathol. 2009) 3 23
  5. Kinetics of transport and phosphorylation of glucose in cancer cells. (PMID: 19681047) RodrA-guez-EnrA-quez S. … Moreno-SA!nchez R. (J. Cell. Physiol. 2009) 3 23

Products for SLC2A3 Gene

Sources for SLC2A3 Gene

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