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SLC2A3 Gene

protein-coding   GIFtS: 66
GCID: GC12M008071

Solute Carrier Family 2 (Facilitated Glucose Transporter),...


(Previous symbol: GLUT3)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 31 2
GLUT31 2 3 5
Glucose Transporter Type 3, Brain2 3
GLUT-32 3
Solute Carrier Family 2, Facilitated Glucose Transporter Member 32

External Ids:    HGNC: 110071   Entrez Gene: 65152   Ensembl: ENSG000000598047   OMIM: 1381705   UniProtKB: P111693   

Export aliases for SLC2A3 gene to outside databases

Previous GC identifers: GC12M007767 GC12M008219 GC12M007972 GC12M007963 GC12M007884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for SLC2A3 Gene:
SLC2A3 (solute carrier family 2 (facilitated glucose transporter), member 3) is a protein-coding gene. Diseases associated with SLC2A3 include fetal macrosomia, and acanthosis nigricans. GO annotations related to this gene include glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
Function: Facilitative glucose transporter. Probably a neuronal glucose transporter




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A3 gene promoter:
         STAT5B   c-Fos   AP-1   AML1a   FOXD3   AP-4   LCR-F1   FOXO1a   c-Jun   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): SLC2A3 promoter sequence
   Search Chromatin IP Primers for SLC2A3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.3

SLC2A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M008071:  view genomic region     (about GC identifiers)

Start:
8,071,824 bp from pter      End:
8,088,892 bp from pter
Size:
17,069 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 3  
Size: 496 amino acids; 53924 Da
Secondary accessions: B2R606 D3DUU6 Q6I9U2 Q9UG15

Explore the universe of human proteins at neXtProt for SLC2A3: NX_P11169

Explore proteomics data for SLC2A3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys477
  • Glycosylation2 at Asn43
  • Modification sites at PhosphoSitePlus

  • See SLC2A3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008862.1  
    ENSEMBL proteins: 
     ENSP00000075120   ENSP00000440750   ENSP00000441496  
    Reactome Protein details: P11169

    SLC2A3 Human Recombinant Protein Products:

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    Novus Biologicals SLC2A3 Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    SLC2A3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for SLC2A3 (Glut3)
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    Novus Biologicals SLC2A3 Antibodies
    Abcam antibodies for SLC2A3
    Browse Antibodies at Cloud-Clone Corp.
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    LSBio Antibodies in human, mouse, rat for SLC2A3

    SLC2A3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 3
    Class I transporters

    Selected InterPro protein domains (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR002945 Glc_transpt_3

    Graphical View of Domain Structure for InterPro Entry P11169

    ProtoNet protein and cluster: P11169

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002945 Glucose transporter type 3 (GLUT3) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR3_HUMAN, P11169
    Function: Facilitative glucose transporter. Probably a neuronal glucose transporter

         Genatlas biochemistry entry for SLC2A3:
    solute carrier family 2,member A3,facilitated glucose transporter

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity IEA--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
         
    SLC2A3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for SLC2A3:
     Increased S DNA content 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Slc2a3):
     behavior/neurological  embryogenesis  growth/size/body  homeostasis/metabolism  mortality/aging 
     nervous system  reproductive system 

    SLC2A3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for SLC2A3: Slc2a3tm1Dksr Slc2a3tm1Stua

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC2A3

    miRNA
    Products:
        
    miRTarBase miRNAs that target SLC2A3:
    hsa-mir-10b-5p (MIRT047414), hsa-mir-24-3p (MIRT030481), hsa-mir-148a-3p (MIRT048026), hsa-mir-335-5p (MIRT018188), hsa-mir-10a-5p (MIRT047530), hsa-mir-34a-5p (MIRT025389), hsa-mir-183-5p (MIRT047050), hsa-mir-98-5p (MIRT027670), hsa-mir-195-5p (MIRT006235)

    Block miRNA regulation of human, mouse, rat SLC2A3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate SLC2A3 (see all 57):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-1273d hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for SLC2A3
    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A3

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for SLC2A3 (see all 6)
    OriGene ORF clones in mouse, rat for SLC2A3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: SLC2A3 (NM_006931)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR3_HUMAN, P11169: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA--

    SLC2A3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A3 About   (see all 10)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Defective BTD causes biotidinase deficiency
    Defective BTD causes biotidinase deficiency1.00
    Metabolism of vitamins and cofactors1.00
    Defective AMN causes hereditary megaloblastic anemia 11.00
    Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC1.00
    Defective MMAA causes methylmalonic aciduria type cblA1.00
    Defective MUT causes methylmalonic aciduria mut type1.00
    Defective CD320 causes methylmalonic aciduria1.00
    Defects in cobalamin (B12) metabolism1.00
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Facilitative Na+-independent glucose transporters0.00
    3Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87
    4Glycolysis and gluconeogenesis short map
    Glycolysis and Gluconeogenesis0.60
    5PAK Pathway
    Antioxidant Action of Vitamin-C0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A3
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway

    1 BioSystems Pathway for SLC2A3
        Glycolysis and Gluconeogenesis

    3 Reactome Pathways for SLC2A3
        Facilitative Na+-independent glucose transporters
    Glucose transport
    Vitamin C (ascorbate) metabolism



    SLC2A3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A3: 
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC2A3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for SLC2A3 (P111692, 3 ENSP000000751204) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGB1Q147892, 3, ENSP000003418484MINT-64178 I2D: score=3 STRING: ENSP00000341848
    H3F3AP842433I2D: score=1 
    H3F3BP842433I2D: score=1 
    CREB3O438893I2D: score=1 
    SNTA1Q134243I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006766vitamin metabolic process TAS--
    GO:0006767water-soluble vitamin metabolic process TAS--
    GO:0006810transport ----
    GO:0008645hexose transport TAS--

    SLC2A3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A3 (GTR3)

    1 IUPHAR Ligand for SLC2A3 (Glucose transporter 3)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]2-deoxyglucose
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for SLC2A3 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 78.1 212 17559076 (5), 11080093 (4), 7804607 (3), 1704223 (3) (see all 99)
    2-deoxyglucose 70.4 7 1420159 (2), 10336639 (2), 19646954 (1), 12960090 (1)
    cytochalasin b 69.2 4 1420159 (1), 8504756 (1), 1417839 (1)
    dehydroascorbic acid 66.2 12 16142743 (2), 15590689 (1), 14642847 (1), 19391462 (1) (see all 5)
    18f fluorodeoxyglucose 40.4 2 19536037 (2)
    ribonucleic acid 31.5 3 9253355 (1), 10199793 (1), 18371555 (1)
    betamethasone 28 5 16782269 (3), 17359461 (2)
    2,4-dinitrophenol 27.8 7 9677332 (5), 7619042 (1)
    ascorbic acid 27.1 2 12381735 (1), 10438494 (1)
    vegf 17.2 6 9724644 (2), 17611657 (2), 17651733 (1), 18371555 (1)



    SLC2A3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for SLC2A3 gene: 
    NM_006931.2  

    Unigene Cluster for SLC2A3:

    Solute carrier family 2 (facilitated glucose transporter), member 3
    Hs.419240  [show with all ESTs]
    Unigene Representative Sequence: AB209607
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000075120(uc001qtr.3) ENST00000543435 ENST00000486749 ENST00000469295
    ENST00000479059 ENST00000490763 ENST00000495813 ENST00000544291 ENST00000544936
    ENST00000476634 ENST00000541671
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC2A3 (see all 57):
    hsa-miR-642a hsa-miR-1321 hsa-miR-146a hsa-miR-15a hsa-miR-25 hsa-miR-503 hsa-miR-1273d hsa-miR-424
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A3
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    OriGene clones in human, mouse for SLC2A3 (see all 6)
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    GenScript: all cDNA clones in your preferred vector: SLC2A3 (NM_006931)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A3
    Primer
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    OriGene qPCR primer pairs and template standards for SLC2A3
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat SLC2A3
      QuantiTect SYBR Green Assays in human, mouse, rat SLC2A3
      QuantiFast Probe-based Assays in human, mouse, rat SLC2A3

    Additional mRNA sequence: 

    AB209607.1 AK074861.1 AK298673.1 AK304509.1 AK312386.1 AY034634.1 BC039196.1 CR457413.1 
    M20681.1 

    Selected DOTS entries (see all 47):

    DT.455164  DT.100860784  DT.121143646  DT.121143691  DT.100860785  DT.121143772  DT.85100190  DT.100697253 
    DT.91650532  DT.95069469  DT.121143670  DT.121143672  DT.92012780  DT.121143630  DT.100860779  DT.121143642 
    DT.99984415  DT.121143745  DT.121143751  DT.100710420  DT.121143674  DT.85100193  DT.91691507  DT.100860781 

    Selected AceView cDNA sequences (see all 489):

    BI021109 BM556019 AA350577 BM561800 NM_153449 BM548719 BX357715 BU850207 
    CD672991 AA171601 AY034634 AA406552 BP343186 N57046 CA440927 AL702725 
    BU071967 BM802877 BM926950 BM561608 CR621471 BM476335 T29744 CD656442 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A3 (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d ^ 12a · 12b
    SP1:                                                                                                                                                            
    SP2:                                -                 -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP3:                                -                                                                                                                           
    SP4:                                                                                                                                                            
    SP5:                                -           -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for SLC2A3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLC2A3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAACTTCTG
    SLC2A3 Expression
    About this image


    SLC2A3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 4 entries
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Villous Cytotrophoblast Cells Chorionic Villus
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T Helper Cells Thymus
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Epithelial Cells
             Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
    SLC2A3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.419240

    UniProtKB/Swiss-Prot: GTR3_HUMAN, P11169
    Tissue specificity: Highly expressed in brain. Expressed in many tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A3: 
              Drug Transporters in human mouse rat
              Hypoxia Signaling Pathway in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for SLC2A3 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a31 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 80.89(n)1
    83.54(a)1
      6 (57.82 cM)5
    205271  NM_011401.41  NP_035531.31 
     1227278095 
    chicken
    (Gallus gallus)
    Aves SLC2A31 solute carrier family 2 (facilitated glucose transporter), more 70.3(n)
    73.87(a)
      396517  NM_205511.1  NP_990842.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    68(a)
    1 → many
    GL343236.1(1391723-1422178)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004977631 solute carrier family 2, facilitated glucose transporter more 65.49(n)
    68.32(a)
      100497763  XM_002941203.2  XP_002941249.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc2a3a1 solute carrier family 2 (facilitated glucose transporter), more 63.38(n)
    65.09(a)
      436916  NM_001002643.1  NP_001002643.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut11 , 3 glucose transporter3
    Glucose transporter 11
    50(a)
    (best of 5)3
    54.07(n)1
    49.89(a)1
      61E13
    381091  NM_001274304.11  NP_001261233.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H17B01.1a3
    fgt-11
    sugar transporter3
    fgt-11
    43(a)
    (best of 6)3
    51.42(n)1
    44.86(a)1
      II(1504573-1509692)3
    1735251  NM_061580.41  NP_493981.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes STL1(YDR536W)4
    YBR241C1
    Glycerol proton symporter of the plasma membrane, subject more4
    YBR241C1
    44.04(n)1
    30.32(a)1
      4(1508005-1509714)4
    8525431  NP_009800.11  8521494 
     NP_010825.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PGLCT1 PGLCT 47.62(n)
    35.94(a)
      831472  NM_203058.2  NP_974787.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01334001 Os01g0133400 45.52(n)
    34.26(a)
      4325804  NM_001048473.1  NP_001041938.1 


    ENSEMBL Gene Tree for SLC2A3 (if available)
    TreeFam Gene Tree for SLC2A3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A3 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A92  SLC2A142  SLC2A22  SLC2A42  SLC2A12  
    SLC2A112  
    10 SIMAP similar genes for SLC2A3 using alignment to 3 protein entries:     GTR3_HUMAN (see all proteins):
    SLC2A14    SLC2A1    SLC2A2    SLC2A4    SLC2A5    SLC2A9
    SLC2A7    SLC2A11    SLC2A11-a    SLC2A11-c

    SLC2A3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for SLC2A3
    PGOHUM00000244056 PGOHUM00000249736


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC2A3 (see all 562)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2016459051,2
    C--8071342(+) GTTTT-/TTTTGA 1 -- ds50010--------
    rs1811650551,2
    --8071350(+) TGAGAC/TGGAGT 1 -- ds50010--------
    rs1379748621,2
    C--8071394(+) GCGAT-/CCTCTG 1 -- ds50010--------
    rs2010152791,2
    --8071400(+) TCTGC-/GGAG  
            
    TCACC
    1 -- ds50010--------
    rs1857526731,2
    --8071406(+) TCACCA/GCAACC 1 -- ds50010--------
    rs1407343161,2
    --8071418(+) CCGCCA/TCCCAG 1 -- ds50010--------
    rs1501623821,2
    C--8071478(+) GAATGC/GGCCAT 1 -- ds50010--------
    rs1903735751,2
    --8071600(+) GCTGGA/GATTAC 1 -- ds50010--------
    rs1404302331,2
    --8071624(+) CGCGCC/TTGGCC 1 -- ds50010--------
    rs797047311,2
    C,F--8071625(+) GCGCCT/CGGCCA 1 -- ds50013Minor allele frequency- C:0.19WA CSA 122

    HapMap Linkage Disequilibrium report for SLC2A3 (8071824 - 8088892 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC2A3 (see all 43):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv186e201CNV Deletion23290073
    dgv185e201CNV Deletion23290073
    dgv6e196CNV Duplication17116639
    dgv5e196CNV Duplication17116639
    esv2422117CNV Duplication20811451
    dgv183n27CNV Loss19166990
    dgv60e55CNV Loss17911159
    dgv182n27CNV Loss19166990
    dgv1355n71CNV Loss21882294
    dgv1362n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138170    OMIM disorders: --

    Selected diseases for SLC2A3 (see all 46):    
    About MalaCards
    fetal macrosomia    acanthosis nigricans    islet cell tumor    choriocarcinoma
    hyperglycemia    fibrous histiocytoma    histiocytoma    hypoglycemia
    hyperthyroidism    laryngeal carcinoma    pregnancy loss    meningioma
    hypoxia    anorexia nervosa    laryngitis    hyperparathyroidism
    diffuse large b-cell lymphoma    attention deficit hyperactivity disorder    insulin resistance    b-cell lymphomas


    SLC2A3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for SLC2A3 gene (see all 29)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 45 4 9766571 (2), 9179927 (1), 10657852 (1)
    nsclc stage i 43.2 3 9305704 (2), 11551404 (1)
    insulin resistance 22.9 3 11436180 (2), 10070142 (1)
    tumors 22.8 38 9305704 (3), 8314336 (3), 10025844 (3), 16730088 (3) (see all 20)
    diabetes gestational 22.2 1 10086067 (1)
    hyperglycemia 21.3 7 11080093 (3), 9766571 (2), 10070142 (2)
    meningioma 14.7 3 8265814 (1), 1617673 (1)
    hypoglycemia 14.4 6 11080093 (3), 10070142 (2)
    hyperinsulinemia 14.4 1 7559581 (1)
    cancer 13.3 8 18422279 (2), 2372287 (2), 9252709 (1), 9305704 (1) (see all 5)

    Genetic Association Database (GAD): SLC2A3
    Human Genome Epidemiology (HuGE) Navigator: SLC2A3 (4 documents)

    Export disorders for SLC2A3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC2A3 gene, integrated from 10 sources (see all 209):
    (articles sorted by number of sources associating them with SLC2A3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. (PubMed id 19786962)1, 4 Roeske D....Schulte-KAPrne G. (Mol. Psychiatry 2011)
    2. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    3. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PubMed id 20424473)1, 4 Yokoyama K....Hosoya T. (Nephron Clin Pract 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. QLS motif in transmembrane helix VII of the glucose transporter family interacts with the C-1 (position) of D-glucose and is involved in substrate selection at the exofacial binding site. (PubMed id 9477959)1, 2 Seatter M.J.... Gould G.W. (Biochemistry 1998)
    6. Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues. (PubMed id 3170580)1, 2 Kayano T....Bell G.I. (J. Biol. Chem. 1988)
    7. Regenerating human muscle fibres express GLUT3 protein. (PubMed id 12397394)1, 9 Gaster M....der H.D. (Pflugers Arch. 2002)
    8. IGF-1 controls GLUT3 expression in muscle via the transcriptional factor Sp1. (PubMed id 17920708)1, 9 Copland J.A....Stuart C.A. (Biochim. Biophys. Acta 2007)
    9. Regulation of GLUT3 and glucose uptake by the cAMP signalling pathway in the breast cancer cell line ZR-75. (PubMed id 17559076)1, 9 Meneses A.M....Owen G.I. (J. Cell. Physiol. 2008)
    10. Distribution of GLUT3 glucose transporter protein in human tissues. (PubMed id 1417839)1, 9 Shepherd P.R....Kahn B.B. (Biochem. Biophys. Res. Commun. 1992)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6515 HGNC: 11007 AceView: SLC2A3andSLC2A14 Ensembl:ENSG00000059804 euGenes: HUgn6515
    ECgene: SLC2A3 H-InvDB: SLC2A3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for SLC2A3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A3 gene:
    Search GeneIP for patents involving SLC2A3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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