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SLC2A2 Gene

protein-coding   GIFtS: 67
GCID: GC03M170714

Solute Carrier Family 2 (Facilitated Glucose Transporter),...


(Previous symbol: GLUT2)
  See SLC2A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 21 2
GLUT21 2 3 5
Glucose Transporter Type 2, Liver2 3
Solute Carrier Family 2, Facilitated Glucose Transporter Member 22
GLUT-23

External Ids:    HGNC: 110061   Entrez Gene: 65142   Ensembl: ENSG000001635817   OMIM: 1381605   UniProtKB: P111683   

Export aliases for SLC2A2 gene to outside databases

Previous GC identifers: GC03M167856 GC03M171763 GC03M172116 GC03M172035 GC03M172196 GC03M168084


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A2 Gene:
This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney
epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity
for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility
to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative
splicing results in multiple transcript variants of this gene. (provided by RefSeq, Jul 2013)

GeneCards Summary for SLC2A2 Gene:
SLC2A2 (solute carrier family 2 (facilitated glucose transporter), member 2) is a protein-coding gene. Diseases associated with SLC2A2 include fanconi bickel syndrome, and fanconi syndrome. GO annotations related to this gene include hexose transmembrane transporter activity and dehydroascorbic acid transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR2_HUMAN, P11168
Function: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose
across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may
comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose
cotransporter in the transcellular transport of glucose in the small intestine and kidney




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A2 gene promoter:
         LHX3b/Lhx3b   AP-1   ATF-2   HNF-4alpha2   CUTL1   Cdc5   HNF-4alpha1   Max   LHX3a/Lhx3a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A2 promoter sequence
   Search Chromatin IP Primers for SLC2A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.1-q26.2   Ensembl cytogenetic band:  3q26.2   HGNC cytogenetic band: 3q26.2-q27

SLC2A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M170714:  view genomic region     (about GC identifiers)

Start:
170,714,137 bp from pter      End:
170,744,768 bp from pter
Size:
30,632 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GTR2_HUMAN, P11168 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 2  
Size: 524 amino acids; 57490 Da
Secondary accessions: A8K481 B2R936 Q9UCW9

Explore the universe of human proteins at neXtProt for SLC2A2: NX_P11168

Explore proteomics data for SLC2A2 at MOPED

Post-translational modifications: 

  • N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells (By similarity)1
  • Glycosylation2 at Asn62
  • Modification sites at PhosphoSitePlus

  • See SLC2A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_000331.1  NP_001265587.1  NP_001265588.1  

    ENSEMBL proteins: 
     ENSP00000323568   ENSP00000418456   ENSP00000417918   ENSP00000418888   ENSP00000372258  
    Reactome Protein details: P11168

    SLC2A2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC2A2 

     
    antibodies-online proteins for SLC2A2 (3 products) 

     
    antibodies-online peptides for SLC2A2

    SLC2A2 Antibody Products:

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    antibodies-online antibodies for SLC2A2 (50 products) 

    SLC2A2 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 2
    Class I transporters

    Selected InterPro protein domains (see all 6):
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR002440 Glc_transpt_2
     IPR020846 MFS_dom

    Graphical View of Domain Structure for InterPro Entry P11168

    ProtoNet protein and cluster: P11168

    4 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB002440 Glucose transporter type 2 (GLUT2) signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR2_HUMAN, P11168
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR2_HUMAN, P11168
    Function: Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose
    across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may
    comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose
    cotransporter in the transcellular transport of glucose in the small intestine and kidney

         Genatlas biochemistry entry for SLC2A2:
    solute carrier family 2,member A2,facilitated glucose transporter

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005355glucose transmembrane transporter activity EXP--
    GO:0015149hexose transmembrane transporter activity TAS--
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity ----
    GO:0033300dehydroascorbic acid transporter activity IEA--
         
    Find genes that share ontologies with SLC2A2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for SLC2A2:
     Decreased influenza A virus in  Decreased number of cells in m  Decreased viability  Increased G1 DNA content 
     Synthetic lethal with Ras 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Slc2a2):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     liver/biliary system  mortality/aging  muscle 

    Find genes that share phenotypes with SLC2A2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Slc2a2tm1Thor for SLC2A2

       genOway: Develop your customized and physiologically relevant rodent model for SLC2A2

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate SLC2A2 (see all 10):
    hsa-miR-3671 hsa-miR-299-5p hsa-miR-3163 hsa-miR-374b hsa-miR-374a hsa-miR-1305 hsa-miR-587 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidSLC2A2 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for SLC2A2 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR2_HUMAN, P11168: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2
    nucleus2
    peroxisome2
    cytosol1
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8027028
    GO:0005903brush border IEA--
    GO:0016020membrane TAS8027028

    Find genes that share ontologies with SLC2A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A2 About   (see all 19)  
    See pathways by source

    SuperPathContained pathways About
    1Type II diabetes mellitus
    Type II diabetes mellitus0.38
    Type II diabetes mellitus0.35
    Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics0.38
    2Regulation of beta-cell development
    Regulation of beta-cell development0.64
    Maturity onset diabetes of the young0.61
    Regulation of gene expression in beta cells0.64
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.47
    Facilitative Na+-independent glucose transporters0.00
    4Regulation of Glucokinase by Glucokinase Regulatory Protein
    Glucose transport0.87
    Hexose transport0.87
    5Integration of energy metabolism
    Integration of energy metabolism0.75
    Regulation of Insulin Secretion0.75


    Find genes that share SuperPaths with SLC2A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A2
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway
    MODY (Maturity-Onset Diabetes of Young)

    3 BioSystems Pathways for SLC2A2
        Type II diabetes mellitus
    Glycolysis and Gluconeogenesis
    FOXA2 and FOXA3 transcription factor networks

    5 Reactome Pathways for SLC2A2
        Regulation of gene expression in beta cells
    Hexose transport
    Regulation of insulin secretion
    Facilitative Na+-independent glucose transporters
    Glucose transport

    1 PharmGKB Pathway for SLC2A2
        Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics

    5 Kegg Pathways  (Kegg details for SLC2A2):
        Insulin secretion
    Prolactin signaling pathway
    Type II diabetes mellitus
    Maturity onset diabetes of the young
    Carbohydrate digestion and absorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A2: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Drug Transporters in human mouse rat
              Fatty Liver in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for SLC2A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for SLC2A2 (P111683 ENSP000003235684) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDX1P529453, ENSP000003704214I2D: score=1 STRING: ENSP00000370421
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    KPNA2P522923, ENSP000003324554I2D: score=2 STRING: ENSP00000332455
    HNF1AENSP000002575554STRING: ENSP00000257555
    SLC2A5ENSP000003666414STRING: ENSP00000366641
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006112energy reserve metabolic process TAS--
    GO:0008645hexose transport TAS--
    GO:0015758glucose transport TAS--
    GO:0031018endocrine pancreas development TAS--

    Find genes that share ontologies with SLC2A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A2 (GTR2)

    1 DrugBank Compound for SLC2A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Streptozocin-- 18883-66-4targetligand9421374 7926307

    1 IUPHAR Ligand for SLC2A2 (Glucose transporter 2)    About this table
    LigandTypeActionAffinityPubmed IDs
    [3H]2-deoxyglucose
    NoneNone--

    Selected Novoseek inferred chemical compound relationships for SLC2A2 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glucose 79.1 350 7491941 (6), 9867217 (5), 15919789 (5), 16669350 (4) (see all 99)
    preproinsulin 70.4 6 11319727 (2), 15935394 (2), 9513084 (1)
    3-o-methylglucose 67.9 5 9446781 (1), 8626492 (1), 9751501 (1), 7593639 (1)
    2-deoxyglucose 66.6 17 9477959 (3), 1420159 (1), 9166863 (1), 8027028 (1) (see all 7)
    cytochalasin b 65.4 7 1716731 (2), 8865815 (2), 9166863 (1), 1716988 (1)
    fructose 61.6 21 9477959 (3), 9166863 (2), 9751501 (2), 9073126 (1) (see all 10)
    glycogen 51.5 7 11915024 (4), 11810292 (1), 7805957 (1), 10987651 (1)
    c-peptide 51.1 4 16109755 (2), 17226789 (1)
    proglucagon 45.2 1 12193567 (1)
    galactose 44.8 2 11810292 (1), 16669350 (1)



    Find genes that share compounds with SLC2A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC2A2 gene (3 alternative transcripts): 
    NM_000340.1  NM_001278658.1  NM_001278659.1  

    Unigene Cluster for SLC2A2:

    Solute carrier family 2 (facilitated glucose transporter), member 2
    Hs.167584  [show with all ESTs]
    Unigene Representative Sequence: NM_000340
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000314251(uc003fhe.1 uc003fhf.1 uc011bpu.1) ENST00000497642
    ENST00000469787 ENST00000471379 ENST00000461867 ENST00000382808
    miRNA
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    hsa-miR-3671 hsa-miR-299-5p hsa-miR-3163 hsa-miR-374b hsa-miR-374a hsa-miR-1305 hsa-miR-587 hsa-miR-3613-3p
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      QuantiFast Probe-based Assays in human, mouse, rat SLC2A2

    Additional mRNA sequence: 

    AK290846.1 AK292741.1 AK298418.1 AK313622.1 BC060041.1 J03810.1 

    5 DOTS entries:

    DT.213866  DT.95261969  DT.91699272  DT.40242631  DT.95243927 

    Selected AceView cDNA sequences (see all 112):

    CB164808 AI522244 NM_000340 J03810 AV653514 AV684100 AV649247 T95962 
    CB161486 AV647943 H60496 C21156 BF224453 BX956217 CB162632 W03283 
    BX483684 AW614449 BC060041 CB164514 CB162316 BX483683 AI769510 BX100873 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                              
    SP2:                          -                                                   


    ECgene alternative splicing isoforms for SLC2A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    SLC2A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCAGACAT
    SLC2A2 Expression
    About this image


    SLC2A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 7 entries
             Mature Beta Cells Islets of Langerhans
             Islet-like clusters
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Epithelial Cells
             Proximal Tubule Cells Proximal Tubule
     
     Adipose (Muscoskeletal System)
             Visceral White Adipocytes Visceral White Adipose
     
     Kidney (Urinary System)
             Proximal Tubule Cells Proximal Tubule
    SLC2A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.167584

    UniProtKB/Swiss-Prot: GTR2_HUMAN, P11168
    Tissue specificity: Liver, insulin-producing beta cell, small intestine and kidney

        Pathway & Disease-focused RT2 Profiler PCR Arrays including SLC2A2: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Drug Transporters in human mouse rat
              Fatty Liver in human mouse rat

    Primer
    Products:
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for SLC2A2 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Slc2a21 , 5 solute carrier family 2 (facilitated glucose transporter), more1, 5 81.77(n)1
    82.03(a)1
      3 (12.19 cM)5
    205261  NM_031197.21  NP_112474.21 
     286979035 
    chicken
    (Gallus gallus)
    Aves SLC2A21 solute carrier family 2 (facilitated glucose transporter), more 66.54(n)
    66.02(a)
      396272  NM_207178.1  NP_997061.1 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A26
    solute carrier family 2 (facilitated glucose trans...
    59(a)
    1 ↔ 1
    3(7331737-7348734)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX847139.12   -- 75.07(n)    BX847139.1 
    zebrafish
    (Danio rerio)
    Actinopterygii slc2a21 solute carrier family 2 (facilitated glucose transporter), more 62.05(n)
    61.45(a)
      322493  NM_001042721.1  NP_001036186.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Glut13 glucose transporter 41(a)
    (best of 5)
      61E1   --
    worm
    (Caenorhabditis elegans)
    Secernentea H17B01.1a3 sugar transporter 39(a)
    (best of 3)
      II(1504573-1509692)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SNF3(YDL194W)4 Plasma membrane low glucose sensor that regulates glucose more   --   4(111580-114234) 851333  NP_010087.1 


    ENSEMBL Gene Tree for SLC2A2 (if available)
    TreeFam Gene Tree for SLC2A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for SLC2A2 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A32  SLC2A92  SLC2A142  SLC2A42  SLC2A12  
    SLC2A112  
    12 SIMAP similar genes for SLC2A2 using alignment to 6 protein entries:     GTR2_HUMAN (see all proteins):
    SLC2A3    SLC2A14    SLC2A4    SLC2A1    SLC2A5    SLC2A7
    SLC2A9    SLC2A11    SLC2A11-a    SLC2A11-c    SLC2A10    SLC2A8

    Find genes that share paralogs with SLC2A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for SLC2A2 (see all 695)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs289288741,2,,4
    CFanconi-Bickel syndrome (FBS)4 pathogenic1170578780(-) CATGGA/TGGCTG 2 E V mis10--------
    VAR_0186514
    Fanconi-Bickel syndrome (FBS)4--see VAR_0186512 L P mis40--------
    VAR_0186524
    Fanconi-Bickel syndrome (FBS)4--see VAR_0186522 P L mis40--------
    rs1219097411,2
    Cpathogenic1170587652(-) CCATCA/GTCACG 2 I V mis10--------
    rs353721061,2
    C--168104532(+) CTTTTC/-TTTTT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs25441,2
    C--168106023(+) CCCCCC/TGTGAT 1 -- int10--------
    rs1122307761,2
    C--168106023(+) CCCCCT/-GTGAT 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs2014721431,2
    --168110050(+) CACAC-/AGAAATC 1 -- int10--------
    rs1444830981,2
    C--168112964(+) ATACA-/TTTATA 1 -- int10--------
    rs1417375151,2
    C--170576353(+) TCTCTA/GCAAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for SLC2A2 (170714137 - 170744768 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for SLC2A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5347n71CNV Loss21882294
    nsv509866CNV Loss20534489
    nsv236991CNV Loss16902084
    nsv7356OTHER Inversion18451855
    esv259965OTHER Complex20981092
    esv259438OTHER Complex20981092

    Human Gene Mutation Database (HGMD): SLC2A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A2
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 138160   
    OMIM disorders: 135853  227810  
    UniProtKB/Swiss-Prot: GTR2_HUMAN, P11168
  • Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal
    recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and
    impaired utilization of glucose and galactose. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 6 diseases for SLC2A2:    
    About MalaCards
    fanconi bickel syndrome    fanconi syndrome    tuberous sclerosis complex    insulinoma
    diabetes mellitus    diabetes mellitus, noninsulin-dependent

    4 diseases from the University of Copenhagen DISEASES database for SLC2A2:
    Diabetes mellitus     Hyperglycemia     Insulinoma     Hypoglycemia

    Find genes that share disorders with SLC2A2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for SLC2A2 gene (see all 23)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fanconi-bickel syndrome 96.9 26 11810292 (2), 19480329 (2), 11079206 (1), 15449578 (1) (see all 19)
    renal tubular disorder 70.5 1 11810292 (1)
    insulinoma 61.4 11 12525258 (2), 9166666 (1), 12712243 (1), 8276890 (1) (see all 9)
    glycogen storage disease 58.5 5 10987651 (2), 19223655 (1), 11485019 (1)
    niddm 58.2 52 7983799 (5), 1351429 (4), 9137902 (4), 12017192 (4) (see all 17)
    hyperglycemia 52.1 2 2237405 (1), 16223491 (1)
    neonatal diabetes mellitus 49.6 1 12029458 (1)
    galactosemias 49.2 1 11810292 (1)
    malabsorption 38.9 2 15449578 (1), 19965550 (1)
    hypoglycemia 36.8 1 11810292 (1)

    Genatlas disease: SLC2A2
    glycogen storage disease,hepatorenal with tubular nephropathy and impaired utilization of glucose and
    galactose,Fanconi-Bickel syndrome

    Genetic Association Database (GAD): SLC2A2
    Human Genome Epidemiology (HuGE) Navigator: SLC2A2 (24 documents)

    Export disorders for SLC2A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC2A2 gene, integrated from 10 sources (see all 288):
    (articles sorted by number of sources associating them with SLC2A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. (PubMed id 17636114)1, 4, 9 KilpelAoinen T.O....Laakso M. (Physiol. Genomics 2007)
    2. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. (PubMed id 15983230)1, 4, 9 Laukkanen O....Laakso M. (Diabetes 2005)
    3. Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. (PubMed id 12017192)1, 4, 9 Cha J.Y....Ahn Y.H. (Ann. Clin. Lab. Sci. 2002)
    4. A mutation in GLUT2, not in phosphorylase kinase subunits, in hepato- renal glycogenosis with Fanconi syndrome and low phosphorylase kinase activity. (PubMed id 10987651)1, 2, 9 Burwinkel B.... Kilimann M.W. (Hum. Genet. 1999)
    5. Sequence variations of the pancreatic islet/liver glucose transporter (GLUT2) gene in Japanese subjects with noninsulin dependent diabetes mellitus. (PubMed id 7593414)2, 4, 9 Matsubara A.... Kaku K. (J. Clin. Endocrinol. Metab. 1995)
    6. Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome. (PubMed id 11044475)1, 2, 9 Sakamoto O.... Iinuma K. (Pediatr. Res. 2000)
    7. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. (PubMed id 11344224)1, 4, 9 MA...Pedersen O. (J. Clin. Endocrinol. Metab. 2001)
    8. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1, 4, 9 Dupuis J....Barroso I. (Nat. Genet. 2010)
    9. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. (PubMed id 14551916)1, 4, 9 Barroso I....Wareham N.J. (PLoS Biol. 2003)
    10. A mutation in the Glut2 glucose transporter gene of a diabetic patient abolishes transport activity. (PubMed id 8027028)1, 2, 9 Mueckler M.... Permutt M.A. (J. Biol. Chem. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6514 HGNC: 11006 AceView: SLC2A2 Ensembl:ENSG00000163581 euGenes: HUgn6514
    ECgene: SLC2A2 Kegg: 6514 H-InvDB: SLC2A2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=SLC2A2[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/GLUT2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A2 gene:
    Search GeneIP for patents involving SLC2A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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