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Aliases for SLC2A14 Gene

Aliases for SLC2A14 Gene

  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 14 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 Pseudogene 3 2 3
  • Glucose Transporter Type 14 3 4
  • GLUT14 3 4
  • SLC2A3P3 3
  • GLUT-14 4
  • GLUT3 4

External Ids for SLC2A14 Gene

Previous HGNC Symbols for SLC2A14 Gene

  • SLC2A3P3

Previous GeneCards Identifiers for SLC2A14 Gene

  • GC00U900937
  • GC12M007865
  • GC12M007857
  • GC12M007856
  • GC12M007965

Summaries for SLC2A14 Gene

Entrez Gene Summary for SLC2A14 Gene

  • Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC2A14 Gene

SLC2A14 (Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 14) is a Protein Coding gene. Diseases associated with SLC2A14 include early onset absence epilepsy and xanthogranulomatous cholecystitis. Among its related pathways are PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot for SLC2A14 Gene

  • Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Wiki entry for SLC2A14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A14 Gene

Genomics for SLC2A14 Gene

Regulatory Elements for SLC2A14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC2A14 Gene

7,812,512 bp from pter
7,891,196 bp from pter
78,685 bases
Minus strand

Genomic View for SLC2A14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC2A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A14 Gene

Proteins for SLC2A14 Gene

  • Protein details for SLC2A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 14
    Protein Accession:
    Secondary Accessions:
    • B3KVB5
    • B3KWW7
    • B7Z844
    • B7ZAC3
    • Q6UY84
    • Q8TDB9

    Protein attributes for SLC2A14 Gene

    520 amino acids
    Molecular mass:
    56320 Da
    Quaternary structure:
    No Data Available
    • GLUT14 is a recent (less than 5 M year old) duplication of GLUT3

    Alternative splice isoforms for SLC2A14 Gene


neXtProt entry for SLC2A14 Gene

Proteomics data for SLC2A14 Gene at MOPED

Post-translational modifications for SLC2A14 Gene

  • Glycosylation at Asn 67
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A14 Gene

Domains & Families for SLC2A14 Gene

Gene Families for SLC2A14 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A14: view

Function for SLC2A14 Gene

Molecular function for SLC2A14 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter (By similarity). May have a specific function related to spermatogenesis.

Gene Ontology (GO) - Molecular Function for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity --
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0022857 transmembrane transporter activity --
GO:0022891 substrate-specific transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC2A14: view
genes like me logo Genes that share phenotypes with SLC2A14: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A14 Gene

Localization for SLC2A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for SLC2A14 Gene COMPARTMENTS Subcellular localization image for SLC2A14 gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC2A14: view

Pathways & Interactions for SLC2A14 Gene

SuperPathways for SLC2A14 Gene

Superpath Contained pathways
1 PAK Pathway
genes like me logo Genes that share pathways with SLC2A14: view

Pathways by source for SLC2A14 Gene

1 Qiagen pathway for SLC2A14 Gene

Interacting Proteins for SLC2A14 Gene

Gene Ontology (GO) - Biological Process for SLC2A14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0015992 proton transport IBA --
GO:0030154 cell differentiation IEA --
GO:0035428 hexose transmembrane transport IBA --
genes like me logo Genes that share ontologies with SLC2A14: view

No data available for SIGNOR curated interactions for SLC2A14 Gene

Drugs & Compounds for SLC2A14 Gene

No Compound Related Data Available

Transcripts for SLC2A14 Gene

Unigene Clusters for SLC2A14 Gene

Solute carrier family 2 (facilitated glucose transporter), member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A14 Gene

No ASD Table

Relevant External Links for SLC2A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A14 Gene

mRNA expression in normal human tissues for SLC2A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A14 Gene

This gene is overexpressed in Testis (x26.4) and Whole Blood (x8.4).

Protein differential expression in normal tissues from HIPED for SLC2A14 Gene

This gene is overexpressed in Nasal epithelium (18.2), Monocytes (15.8), Peripheral blood mononuclear cells (14.0), Neutrophil (8.8), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A14 Gene

SOURCE GeneReport for Unigene cluster for SLC2A14 Gene Hs.655169

mRNA Expression by UniProt/SwissProt for SLC2A14 Gene

Tissue specificity: Expressed mainly in testis.
genes like me logo Genes that share expression patterns with SLC2A14: view

Protein tissue co-expression partners for SLC2A14 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for SLC2A14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A14 35
  • 99.13 (n)
  • 98.69 (a)
SLC2A14 36
  • 98 (a)
(Bos Taurus)
Mammalia SLC2A3 36
  • 84 (a)
(Canis familiaris)
Mammalia SLC2A3 36
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Mus musculus)
Mammalia Slc2a3 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
(Gallus gallus)
Aves SLC2A3 36
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
(Danio rerio)
Actinopterygii LOC100330897 35
  • 60.01 (n)
  • 60.69 (a)
slc2a3a 36
  • 57 (a)
slc2a3b 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Glut1 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea C03B1.13 36
  • 20 (a)
C35A11.4 36
  • 26 (a)
F13B12.2 36
  • 22 (a)
F14E5.1 36
  • 25 (a)
F48E3.2 36
  • 20 (a)
F53H8.3 36
  • 24 (a)
fgt-1 36
  • 38 (a)
K08F9.1 36
  • 26 (a)
K08H10.6 36
  • 21 (a)
R09B5.11 36
  • 35 (a)
slcf-2 36
  • 17 (a)
Y37A1A.3 36
  • 22 (a)
Y39E4B.5 36
  • 19 (a)
Y61A9LA.1 36
  • 20 (a)
ZK829.9 36
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 27 (a)
VPS73 36
  • 25 (a)
HXT13 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7972 36
  • 44 (a)
Species with no ortholog for SLC2A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SLC2A14 Gene

Gene Tree for SLC2A14 (if available)
Gene Tree for SLC2A14 (if available)

Paralogs for SLC2A14 Gene

genes like me logo Genes that share paralogs with SLC2A14: view

Variants for SLC2A14 Gene

Sequence variations from dbSNP and Humsavar for SLC2A14 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1043712 -- 7,827,582(-) GTGCT(A/G)GAGCT synonymous-codon, reference
rs1056992 -- 7,843,806(+) CCTCT(A/G)GATCC intron-variant
rs1128810 -- 7,871,955(+) TGAGC(A/C)CTGaa intron-variant
rs1894820 -- 7,813,930(-) TACAT(A/G)TGAGT utr-variant-3-prime
rs1894821 -- 7,813,909(-) GAGGG(G/T)GTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC2A14 Gene

Variant ID Type Subtype PubMed ID
dgv5e196 CNV Duplication 17116639
dgv6e196 CNV Duplication 17116639
esv2422393 CNV Duplication 17116639
dgv57e55 CNV Gain 17911159
dgv454e1 CNV Complex 17122850
dgv455e1 CNV Complex 17122850
nsv428270 CNV Gain 18775914
dgv1354n71 CNV Gain 21882294
dgv456e1 CNV Complex 17122850
nsv7227 OTHER Inversion 18451855
esv2745493 CNV Deletion 23290073
dgv457e1 CNV Complex 17122850
nsv596 CNV Insertion 18451855
esv2656717 CNV Deletion 23128226
nsv516107 CNV Gain+Loss 19592680
dgv58e55 CNV Gain 17911159
essv10974 CNV CNV 17122850
esv34016 CNV Loss 18971310
esv2751114 CNV Loss 17911159
nsv499606 OTHER Inversion 21111241
esv2745494 CNV Deletion 23290073
esv2671590 CNV Deletion 23128226
dgv1355n71 CNV Loss 21882294
dgv179n27 CNV Gain 19166990
dgv1356n71 CNV Gain 21882294
dgv1357n71 CNV Gain 21882294
esv2658754 CNV Deletion 23128226
dgv185e201 CNV Deletion 23290073
nsv818883 CNV Gain 17921354
nsv470264 CNV Gain 18288195
nsv898650 CNV Gain 21882294
dgv1358n71 CNV Gain 21882294
dgv1359n71 CNV Gain 21882294
dgv1360n71 CNV Gain 21882294
dgv1361n71 CNV Gain+Loss 21882294
nsv470265 CNV Loss 18288195
dgv180n27 CNV Gain 19166990
dgv186e201 CNV Deletion 23290073
esv29743 CNV Gain 19812545
dgv181n27 CNV Loss 19166990
dgv182n27 CNV Loss 19166990
nsv818884 CNV Gain 17921354
esv2422117 CNV Duplication 20811451
dgv183n27 CNV Loss 19166990
nsv826225 CNV Gain 20364138
dgv1362n71 CNV Loss 21882294
nsv442253 CNV CNV 18776908
nsv898695 CNV Loss 21882294
nsv898701 CNV Gain 21882294
dgv59e55 CNV Gain 17911159
esv2751118 CNV Gain 17911159
essv22724 CNV CNV 17122850
dgv60e55 CNV Loss 17911159
dgv458e1 CNV Complex 17122850
esv2751124 CNV Gain 17911159
nsv469100 CNV Gain 19166990
dgv1363n71 CNV Gain 21882294

Variation tolerance for SLC2A14 Gene

Residual Variation Intolerance Score: 50.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.61; 65.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A14 Gene

Disorders for SLC2A14 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC2A14 Gene - From: DISEASES

- elite association

Relevant External Links for SLC2A14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC2A14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC2A14 Gene

Publications for SLC2A14 Gene

  1. Estrogen and progesterone up-regulate glucose transporter expression in ZR-75-1 human breast cancer cells. (PMID: 12960090) Medina R.A. … Owen G.I. (Endocrinology 2003) 23 67
  2. GLUT14, a duplicon of GLUT3, is specifically expressed in testis as alternative splice forms. (PMID: 12504846) Wu X. … Freeze H.H. (Genomics 2002) 2 67
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  4. Genetic association of SLC2A14 polymorphism with Alzheimer's disease in a Han Chinese population. (PMID: 22421804) Wang W. … Tan L. (J. Mol. Neurosci. 2012) 67
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 67

Products for SLC2A14 Gene

Sources for SLC2A14 Gene

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