Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC2A13 Gene

Aliases for SLC2A13 Gene

  • Solute Carrier Family 2 Member 13 2 3 4 5
  • H(+)-Myo-Inositol Symporter 2 3 4
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 13 2 3
  • H(+)-Myo-Inositol Cotransporter 3 4
  • HMIT 3 4
  • Proton (H+) Myo-Inositol Symporter 3
  • Proton Myo-Inositol Cotransporter 3

External Ids for SLC2A13 Gene

Previous GeneCards Identifiers for SLC2A13 Gene

  • GC12M040312
  • GC12M040051
  • GC12M039869
  • GC12M038438
  • GC12M037175
  • GC12M040152

Summaries for SLC2A13 Gene

GeneCards Summary for SLC2A13 Gene

SLC2A13 (Solute Carrier Family 2 Member 13) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include receptor activity and sugar:proton symporter activity. An important paralog of this gene is SLC2A12.

UniProtKB/Swiss-Prot for SLC2A13 Gene

  • H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.

Gene Wiki entry for SLC2A13 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A13 Gene

Genomics for SLC2A13 Gene

Regulatory Elements for SLC2A13 Gene

Enhancers for SLC2A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F040014 1.1 Ensembl ENCODE 11.8 +89.7 89747 4.1 SCRT2 ZNF341 ZNF133 FOS PRDM1 ATF2 LOC101930164 SLC2A13 LRRK2 RPL30P13 GC12P039941
GH12F040012 1.4 Ensembl ENCODE 11.8 +92.8 92823 1.5 ZMYM3 FEZF1 PRDM1 LOC105369734 LOC101930164 SLC2A13 LRRK2 RPL30P13 GC12P039941
GH12F040011 1.1 Ensembl ENCODE 11.8 +94.5 94509 0.8 CTCF ZNF654 TEAD1 TEAD4 CEBPB TRIM22 REST RAD21 TEAD3 ZKSCAN1 SLC2A13 RPL30P13 GC12P039941
GH12F040137 0.5 Ensembl ENCODE 11 -31.3 -31313 0.4 SLC2A13 GC12M040120 LOC105369734
GH12F040031 0.7 ENCODE 10.7 +73.2 73225 2.3 PKNOX1 TEAD4 RAD21 JUND ZNF316 HNF4G SMC3 MAFK LOC101930164 SLC2A13 LRRK2 RPL30P13 GC12P039941
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around SLC2A13 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000429158 89 4001 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 ZNF48 GLIS2 CBX5 ZNF143 ZNF263

Genomic Location for SLC2A13 Gene

Chromosome:
12
Start:
39,755,021 bp from pter
End:
40,106,089 bp from pter
Size:
351,069 bases
Orientation:
Minus strand

Genomic View for SLC2A13 Gene

Genes around SLC2A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A13 Gene

Proteins for SLC2A13 Gene

  • Protein details for SLC2A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QE2-MYCT_HUMAN
    Recommended name:
    Proton myo-inositol cotransporter
    Protein Accession:
    Q96QE2
    Secondary Accessions:
    • Q17S07

    Protein attributes for SLC2A13 Gene

    Size:
    648 amino acids
    Molecular mass:
    70371 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI17118.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAI17120.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAC51116.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SLC2A13 Gene

Post-translational modifications for SLC2A13 Gene

Other Protein References for SLC2A13 Gene

No data available for DME Specific Peptides for SLC2A13 Gene

Domains & Families for SLC2A13 Gene

Gene Families for SLC2A13 Gene

Suggested Antigen Peptide Sequences for SLC2A13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96QE2

UniProtKB/Swiss-Prot:

MYCT_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
genes like me logo Genes that share domains with SLC2A13: view

Function for SLC2A13 Gene

Molecular function for SLC2A13 Gene

UniProtKB/Swiss-Prot Function:
H(+)-myo-inositol cotransporter. Can also transport related stereoisomers.

Gene Ontology (GO) - Molecular Function for SLC2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity IBA --
GO:0005355 glucose transmembrane transporter activity IBA --
GO:0005366 myo-inositol:proton symporter activity TAS --
GO:0022857 transmembrane transporter activity IEA --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A13: view
genes like me logo Genes that share phenotypes with SLC2A13: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A13

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A13 Gene

Localization for SLC2A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A13 Gene COMPARTMENTS Subcellular localization image for SLC2A13 gene
Compartment Confidence
plasma membrane 5
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC2A13: view

Pathways & Interactions for SLC2A13 Gene

genes like me logo Genes that share pathways with SLC2A13: view

Interacting Proteins for SLC2A13 Gene

Gene Ontology (GO) - Biological Process for SLC2A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015798 myo-inositol transport IEA --
GO:0015992 proton transport IEA --
GO:0035428 hexose transmembrane transport IBA --
GO:0046323 glucose import IBA --
genes like me logo Genes that share ontologies with SLC2A13: view

No data available for SIGNOR curated interactions for SLC2A13 Gene

Transcripts for SLC2A13 Gene

Unigene Clusters for SLC2A13 Gene

Solute carrier family 2 (facilitated glucose transporter), member 13:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A13 Gene

No ASD Table

Relevant External Links for SLC2A13 Gene

GeneLoc Exon Structure for
SLC2A13
ECgene alternative splicing isoforms for
SLC2A13

Expression for SLC2A13 Gene

mRNA expression in normal human tissues for SLC2A13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A13 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x4.5) and Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for SLC2A13 Gene

This gene is overexpressed in Adrenal (41.3) and Pancreas (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A13 Gene



Protein tissue co-expression partners for SLC2A13 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A13 Gene:

SLC2A13

SOURCE GeneReport for Unigene cluster for SLC2A13 Gene:

Hs.558595

mRNA Expression by UniProt/SwissProt for SLC2A13 Gene:

Q96QE2-MYCT_HUMAN
Tissue specificity: Predominantly expressed in the brain.
genes like me logo Genes that share expression patterns with SLC2A13: view

Primer Products

Orthologs for SLC2A13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SLC2A13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A13 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia SLC2A13 34 35
  • 94.7 (n)
dog
(Canis familiaris)
Mammalia SLC2A13 34 35
  • 93.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
-- 35
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia SLC2A13 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a13 34 16 35
  • 85.4 (n)
rat
(Rattus norvegicus)
Mammalia Slc2a13 34
  • 85.35 (n)
chicken
(Gallus gallus)
Aves SLC2A13 34 35
  • 81.7 (n)
lizard
(Anolis carolinensis)
Reptilia SLC2A13 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a13 34
  • 76.07 (n)
zebrafish
(Danio rerio)
Actinopterygii SLC2A13 (3 of 3) 35
  • 72 (a)
OneToMany
slc2a13b 34 35
  • 65.03 (n)
SLC2A13 (1 of 3) 35
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hmit-1.3 34 35
  • 50.4 (n)
M01F1.5 36
  • 39 (a)
Y51A2D.4 36
  • 39 (a)
Y51A2D.5 36
  • 37 (a)
hmit-1.1 35
  • 37 (a)
OneToMany
hmit-1.2 35
  • 35 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C12309g 34
  • 48.03 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ITR2 34 35 37
  • 47.88 (n)
-- 35
  • 27 (a)
ManyToMany
ITR1 35
  • 24 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR343C 34
  • 46.18 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons INT1 34
  • 51.42 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1070 34
rice
(Oryza sativa)
Liliopsida Os04g0491700 34
  • 50.08 (n)
Os.10117 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes itr2 34
  • 48.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 46 (a)
OneToOne
Species where no ortholog for SLC2A13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A13 Gene

ENSEMBL:
Gene Tree for SLC2A13 (if available)
TreeFam:
Gene Tree for SLC2A13 (if available)

Paralogs for SLC2A13 Gene

Paralogs for SLC2A13 Gene

(3) SIMAP similar genes for SLC2A13 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for SLC2A13 Gene

genes like me logo Genes that share paralogs with SLC2A13: view

Variants for SLC2A13 Gene

Sequence variations from dbSNP and Humsavar for SLC2A13 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1005955 -- 39,947,047(+) CTCTA(C/T)CCGCT intron-variant
rs1005956 -- 39,947,283(+) CCCCT(C/T)TACTA intron-variant
rs10082797 -- 40,071,138(+) CTTAA(A/G)AAGTC intron-variant
rs10083196 -- 39,776,729(+) TGAGA(A/C)ATTTT intron-variant
rs10083206 -- 40,073,007(+) ccaca(C/T)tggtt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC2A13 Gene

Variant ID Type Subtype PubMed ID
dgv1489n100 CNV loss 25217958
dgv1490n100 CNV loss 25217958
dgv805n106 CNV tandem duplication 24896259
esv22092 CNV loss 19812545
esv2421863 CNV deletion 20811451
esv2657004 CNV deletion 23128226
esv2661429 CNV deletion 23128226
esv2677205 CNV deletion 23128226
esv2678856 CNV deletion 23128226
esv27366 CNV loss 19812545
esv2745779 CNV deletion 23290073
esv2745780 CNV deletion 23290073
esv2745781 CNV deletion 23290073
esv2759895 CNV loss 17122850
esv2760268 CNV loss 21179565
esv3629273 CNV loss 21293372
esv3629275 CNV loss 21293372
esv3629276 CNV loss 21293372
esv3629279 CNV loss 21293372
esv3629280 CNV loss 21293372
esv3629281 CNV loss 21293372
esv3629282 CNV loss 21293372
esv3629283 CNV loss 21293372
nsv1048258 CNV gain 25217958
nsv1113475 CNV deletion 24896259
nsv1113476 CNV deletion 24896259
nsv1115490 CNV deletion 24896259
nsv1120257 CNV tandem duplication 24896259
nsv1138124 CNV deletion 24896259
nsv428280 CNV loss 18775914
nsv436152 CNV deletion 17901297
nsv442269 CNV loss 18776908
nsv477985 CNV novel sequence insertion 20440878
nsv514669 CNV loss 21397061
nsv515811 CNV loss 19592680
nsv522471 CNV loss 19592680
nsv558593 CNV loss 21841781
nsv558594 CNV loss 21841781
nsv558595 CNV loss 21841781
nsv558596 CNV gain 21841781
nsv558597 CNV loss 21841781
nsv681 CNV insertion 18451855
nsv819704 CNV loss 19587683
nsv8966 CNV loss 18304495
nsv8967 CNV gain 18304495
nsv952172 CNV duplication 24416366

Variation tolerance for SLC2A13 Gene

Residual Variation Intolerance Score: 34.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.97; 49.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC2A13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A13 Gene

Disorders for SLC2A13 Gene

Relevant External Links for SLC2A13

Genetic Association Database (GAD)
SLC2A13
Human Genome Epidemiology (HuGE) Navigator
SLC2A13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A13

No disorders were found for SLC2A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A13 Gene

Publications for SLC2A13 Gene

  1. Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. (PMID: 11500374) Uldry M. … Thorens B. (EMBO J. 2001) 2 3 4 64
  2. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. (PMID: 22451204) Pankratz N. … Foroud T. (Ann. Neurol. 2012) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. (PMID: 19915576) Satake W. … Toda T. (Nat. Genet. 2009) 3 46 64
  5. Evaluation of expression and function of the H+/myo-inositol transporter HMIT. (PMID: 19607714) Di Daniel E. … Maycox P.R. (BMC Cell Biol. 2009) 3 22 64

Products for SLC2A13 Gene

Sources for SLC2A13 Gene

Content
Loading form....