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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC2A13 Gene

protein-coding   GIFtS: 53
GCID: GC12M040051

solute carrier family 2 (facilitated glucose transporter),...

 Explore 6 diseases affiliated with
SLC2A13 via our new
 Human Malady Compendium 
Biological research products
for SLC2A13
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 131 2     Proton (H+) Myo-Inositol Symporter2
HMIT1 2 5     Proton Myo-Inositol Cotransporter2
H(+)-Myo-Inositol Cotransporter2 3     Hmit3
H(+)-Myo-Inositol Symporter2 3     

External Ids:    HGNC: 159561   Entrez Gene: 1141342   Ensembl: ENSG000001512297   OMIM: 6110365   UniProtKB: Q96QE23   

Export aliases for SLC2A13 gene to outside databases

Previous GC identifers: GC12M040312 GC12M039869 GC12M038438 GC12M037175


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MYCT_HUMAN, Q96QE2
Function: H(+)-myo-inositol cotransporter. Can also transport related stereoisomers

Gene Wiki entry for SLC2A13


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A13 gene promoter:
         AhR   Elk-1   Pax-5   Pbx1a   NRSF form 1   CUTL1   NRSF form 2   FOXO1a   STAT3   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidSLC2A13 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC2A13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

SLC2A13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A13 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M040051:  view genomic region     (about GC identifiers)

Start:
40,148,823 bp from pter      End:
40,499,891 bp from pter
Size:
351,069 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MYCT_HUMAN, Q96QE2 (See protein sequence)
Recommended Name: Proton myo-inositol cotransporter  
Size: 648 amino acids; 70371 Da
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAI17118.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAI17120.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC51116.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q17S07

Explore the universe of human proteins at neXtProt for SLC2A13: NX_Q96QE2

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96QE2

  • SLC2A13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_443117.3  
    ENSEMBL proteins: 
     ENSP00000280871   ENSP00000370239  
    Reactome Protein details: Q96QE2
    Human Recombinant Protein Products: 
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    Uscn Proteins for SLC2A13

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    SLC2A13 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    SLC2A13 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q96QE2

    ProtoNet protein and cluster: Q96QE2

    2 Blocks protein families:
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: MYCT_HUMAN, Q96QE2
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: MYCT_HUMAN, Q96QE2
    Function: H(+)-myo-inositol cotransporter. Can also transport related stereoisomers

    miRNA
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    hsa-miR-411* hsa-miR-579 hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-300 hsa-miR-449a hsa-miR-570
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022891substrate-specific transmembrane transporter activity IEA--


    SLC2A13 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for SLC2A13:
     Lamellipodia and high actin ra 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport1.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Inositol transporters
    Inositol transporters1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for SLC2A13
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Inositol transporters



    SLC2A13 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A13

    5/11 Interacting proteins for SLC2A13 (Q96QE23) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK2P548193I2D: score=1 
    CADP277083I2D: score=1 
    CBSP355203I2D: score=1 
    DHX8Q145623I2D: score=1 
    FPGSQ059323I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055085transmembrane transport TAS--


    SLC2A13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A13
    Search CenterWatch for drugs/clinical trials and news about SLC2A13 / MYCT 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC2A13 gene: 
    NM_052885.3  

    Unigene Cluster for SLC2A13:

    Solute carrier family 2 (facilitated glucose transporter), member 13
    Hs.558595  [show with all ESTs]
    Unigene Representative Sequence: NM_052885
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000280871(uc010skm.2) ENST00000465517(uc001rme.1) ENST00000380858(uc001rmf.3)


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    hsa-miR-411* hsa-miR-579 hsa-miR-142-5p hsa-miR-4307 hsa-miR-379* hsa-miR-300 hsa-miR-449a hsa-miR-570
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    Additional cDNA sequence: 

    AJ315644.1 AK000182.1 AK026495.1 BC039431.1 BC047507.1 BC117117.1 BC117119.1 

    3 DOTS entries:

    DT.444219  DT.100738505  DT.91966328 

    24/35 AceView cDNA sequences (see all 35):

    CD635364 BX486694 AK000182 AA644240 AL603403 CD635358 BM995856 BC047507 
    BX497350 AL700130 CD635356 CD635366 CD635360 AJ315644 BX110008 CD635348 
    NM_052885 AL120094 BX492538 BX493371 AI168212 BG433825 CD635350 H99108 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC2A13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    SLC2A13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See SLC2A13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC2A13

    SOURCE GeneReport for Unigene cluster: Hs.558595

    UniProtKB/Swiss-Prot: MYCT_HUMAN, Q96QE2
    Tissue specificity: Predominantly expressed in the brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for SLC2A13 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves SLC2A131 solute carrier family 2 (facilitated glucose transporter), more 81.7(n)
    86.31(a)
      769652  XM_001232939.2  XP_001232940.2 
    lizard
    (Anolis carolinensis)
    Reptilia SLC2A136
    --
    88(a)
    1 ↔ 1
    5(98383980-98513767)
    zebrafish
    (Danio rerio)
    Actinopterygii slc2a13b1 solute carrier family 2 (facilitated glucose transporter), more 65.03(n)
    69(a)
      559440  NM_001159829.1  NP_001153301.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51A2D.43
    hmit-1.31
    Sugar (and other) transporters3
    Protein HMIT-1.31
    39(a)
    (best of 3)3
    50.42(n)1
    44.46(a)1
      V(18519464-18526280)3
    1754581  NM_065324.21  NP_497725.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ITR2(YOL103W)4
    ITR21
    Myo-inositol transporter with strong similarity to more4
    Itr2p1
    47.6(n)1
    35.47(a)1
      15(124001-125830)4
    8540501, 4  NP_014538.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons INT11 putative inositol transporter 1 51.53(n)
    42.86(a)
      818934  NM_180062.2  NP_850393.1 
    rice
    (Oryza sativa)
    Liliopsida Os.101172 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.98(n)    AK069132.1 
    E. coli
    (Escherichia coli)
    Gamma proteobacteria galP6
    araE6
    arabinose transporter
    32(a)
    30(a)
    many ↔ many
    many ↔ many
    Chromosome(3086306-3087700)
    Chromosome(2978786-2980204)


    ENSEMBL Gene Tree for SLC2A13 (if available)
    TreeFam Gene Tree for SLC2A13 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC2A13 gene
    SLC2A102  SLC2A122  
    3 SIMAP similar genes for SLC2A13 using alignment to 3 protein entries:     MYCT_HUMAN (see all proteins):
    SLC2A10    SLC2A12    SLC2A14

    SLC2A13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for SLC2A13
    PGOHUM00000249685


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5751 NCBI SNPs in SLC2A13 are shown (see all 5751    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs779598701,2
    C--40148397(+) TGATTA/GAGGCA 1 -- int10--------
    rs790292621,2
    C--40148398(+) GATTGA/TGGCAG 1 -- int10--------
    rs1443860981,2
    --40148427(+) CGGAGC/TCCCAA 1 -- int10--------
    rs111734331,2
    C,F,A,H,--40148465(+) CGATTG/TTTCAT 1 -- int123Minor allele frequency- T:0.18NS EA NA WA 2770
    rs1830102171,2
    --40148640(+) TTTTAG/TGTATT 1 -- int10--------
    rs111734341,2
    C,F,H,--40148791(+) GAAGAT/AAACTA 1 -- int19Minor allele frequency- A:0.17NS EA NA WA 754
    rs1868599611,2
    --40148831(+) ATGAGC/TAATGA 1 -- ut310--------
    rs47681771,2
    H--40149094(+) ACTTAT/CATTGA 1 -- ut314Minor allele frequency- C:0.00NS EA 404
    rs111734401,2
    C,F,H,--40149382(+) TAAATG/TAGATG 1 -- ut319Minor allele frequency- T:0.16NS EA NA WA 760
    rs1905488891,2
    --40149453(+) ATGATC/GCACTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for SLC2A13 (40148823 - 40398823 bp, first 250kb of SLC2A13)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 11 variations for SLC2A13
         8 CNVs: 49073 49072 31887 66202 2981 38262 86339 22865
         3 Indels: 58568 33255 71493

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    SLC2A13 for disorders           About GeneDecksing

    OMIM gene information: 611036    OMIM disorders: --

    6 diseases for SLC2A13:    About MalaCards
    parkinson's disease    lung cancer    tuberculosis    malaria
    neuronitis    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: SLC2A13 (1 document)

    Export disorders for SLC2A13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for SLC2A13 gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with SLC2A13)
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    1. Identification of a mammalian H(+)-myo-inositol symporter expressed predominantly in the brain. (PubMed id 11500374)1, 2, 3 Uldry M.... Thorens B. (2001)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Evaluation of expression and function of the H+/myo-i nositol transporter HMIT. (PubMed id 19607714)1, 9 Di Daniel E....Maycox P.R. (2009)
    5. Meta-analysis of Parkinson's disease: identification o f a novel locus, RIT2. (PubMed id 22451204)1 Pankratz N....Foroud T. (2012)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    8. Identification of genes associated with non-small-cel l lung cancer promotion and progression. (PubMed id 19473719)1 Bankovic J....Tanic N. (2010)
    9. Genome-wide association study identifies common varia nts at four loci as genetic risk factors for Parkinson's disease. (PubMed id 19915576)1 Satake W....Toda T. (2009)
    10. Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. (PubMed id 15203218)1 Fu G.K....Stuve L.L. (2004)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114134 HGNC: 15956 AceView: SLC2A13 Ensembl:ENSG00000151229 euGenes: HUgn114134
    ECgene: SLC2A13 H-InvDB: SLC2A13

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC2A13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A13 gene:
    Search GeneIP for patents involving SLC2A13

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