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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

SLC2A11 Gene

protein-coding   GIFtS: 53
GCID: GC22P024198

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member
111 2
     Glucose Transporter Protein 102
Glucose Transporter Type 102 3     Glucose Transporter Protein 112
Glucose Transporter Type 112 3     Glucose Transporter-Like Protein XI2
GLUT102 3     Solute Carrier Family 2, Facilitated Glucose Transporter Member 112
GLUT112 3     GLUT-103
Facilitative Glucose Transporter GLUT112     GLUT-113

External Ids:    HGNC: 142391   Entrez Gene: 660352   Ensembl: ENSG000001334607   OMIM: 6103675   UniProtKB: Q9BYW13   

Export aliases for SLC2A11 gene to outside databases

Previous GC identifers: GC22U990207 GC22P020895 GC22P022523 GC22P007184


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for SLC2A11 Gene:
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The
encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2013)

GeneCards Summary for SLC2A11 Gene: 
SLC2A11 (solute carrier family 2 (facilitated glucose transporter), member 11) is a protein-coding gene. Diseases associated with SLC2A11 include meningioma, and multiple myeloma, and among its related super-pathways are Transmembrane transport of small molecules and Class II GLUTs. GO annotations related to this gene include substrate-specific transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
Function: Facilitative glucose transporter

Gene Wiki entry for SLC2A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the SLC2A11 gene promoter:
         NF-1   RFX1   Elk-1   p300   HTF   Lmo2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A11 promoter sequence
   Search SABiosciences Chromatin IP Primers for SLC2A11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024198:  view genomic region     (about GC identifiers)

Start:
24,198,890 bp from pter      End:
24,228,496 bp from pter
Size:
29,607 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 11  
Size: 496 amino acids; 53703 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: Has been described as GLUT10 in litterature, but this gene name has already been used for SLC2A10
Secondary accessions: E9PH55 Q542Y4 Q6ICJ5 Q8WXF9 Q8WYM4
Alternative splicing: 4 isoforms:  Q9BYW1-1   Q9BYW1-2   Q9BYW1-3   Q9BYW1-4   

Explore the universe of human proteins at neXtProt for SLC2A11: NX_Q9BYW1

Explore proteomics data for SLC2A11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYW1

  • SLC2A11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    SLC2A11 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001020109.1  NP_001020110.1  NP_001269793.1  NP_110434.3  

    ENSEMBL proteins: 
     ENSP00000342542   ENSP00000385949   ENSP00000381399   ENSP00000384987   ENSP00000255830  
     ENSP00000403654   ENSP00000398439   ENSP00000398746   ENSP00000385156   ENSP00000326748  
    Reactome Protein details: Q9BYW1
    Human Recombinant Protein Products for SLC2A11: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals SLC2A11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    SLC2A11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 11 
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9BYW1

    ProtoNet protein and cluster: Q9BYW1

    3 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    SLC2A11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR11_HUMAN, Q9BYW1
    Function: Facilitative glucose transporter

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity IEA--
         
    SLC2A11 for ontologies           About GeneDecksing


    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A11 
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    Inhib. RNA
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    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for SLC2A11 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    Transmembrane transport of small molecules0.50
    2Facilitative Na+-independent glucose transporters
    Facilitative Na+-independent glucose transporters0.33
    Class II GLUTs0.33
    3PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    4HIF1Alpha Pathway
    HIF1Alpha Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC2A11
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway


    5        Reactome Pathways for SLC2A11
        SLC-mediated transmembrane transport
    Transmembrane transport of small molecules
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Class II GLUTs
    Facilitative Na+-independent glucose transporters



    SLC2A11 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for SLC2A11

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008643carbohydrate transport IEA--
    GO:0055085transmembrane transport TAS--

    SLC2A11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    SLC2A11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for SLC2A11 (GTR11)

    2 Novoseek inferred chemical compound relationships for SLC2A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 63.4 7 11583593 (2), 16154905 (2), 11780753 (1)
    glucose 35.7 7 11741323 (2), 14704796 (1), 11780753 (1), 11583593 (1) (see all 5)

    Search CenterWatch for drugs/clinical trials and news about SLC2A11 / GTR11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for SLC2A11 gene (4 alternative transcripts): 
    NM_001024938.3  NM_001024939.3  NM_001282864.1  NM_030807.4  

    Unigene Cluster for SLC2A11:

    Solute carrier family 2 (facilitated glucose transporter), member 11
    Hs.743282  [show with all ESTs]
    Unigene Representative Sequence: NM_030807
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000345044 ENST00000403208 ENST00000398356(uc002zym.4 uc002zyn.4 uc002zyo.4 uc011ajc.1)
    ENST00000405847 ENST00000467660 ENST00000405286 ENST00000255830 ENST00000489322
    ENST00000440493 ENST00000473740 ENST00000492516 ENST00000423972 ENST00000418102
    ENST00000491948 ENST00000436643 ENST00000405340(uc011ajd.1 uc002zyp.4)
    ENST00000461809(uc002zyl.1) ENST00000316185
    miRNA
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    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for SLC2A11
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC2A11
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A11
    Sirion Biotech Customized lentivirus for stable overexpression of SLC2A11 
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    OriGene qPCR primer pairs and template standards for SLC2A11
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC2A11

    Additional mRNA sequence: 

    AF443201.1 AF479409.1 AJ271290.1 AK075467.1 AK092466.1 AK296169.1 AK300196.1 AK304409.1 
    AK308589.1 AK308602.1 AK314502.1 AK315937.1 AK316049.1 BC018967.2 BC063525.1 BC094735.1 
    BC100807.2 BC100808.2 BC100809.1 BC100810.1 CR456373.1 

    23 DOTS entries:

    DT.207976  DT.100815892  DT.100774696  DT.100774695  DT.91831356  DT.120669483  DT.120669443  DT.422844 
    DT.100831126  DT.120669343  DT.95270457  DT.97825700  DT.40118809  DT.120669437  DT.100689855  DT.120669418 
    DT.92419647  DT.100748967  DT.120669247  DT.120669265  DT.120669380  DT.97817953  DT.100748966 

    1476 AceView cDNA sequences (see top 24):

    AA028035 AI219290 BF061812 AW341498 BQ061588 AA356788 BU190643 BM504318 
    AI336268 BC008914 BM551894 AW009548 H46251 AI674639 AA721058 AI669946 
    BU838070 BF338724 AW163333 CB108556 BM844224 BM696446 BE269667 CR602271 
    AA181313 AI215687 CR456520 H44219 AW005755 BU185117 BE794339 BM824569 
    BM769836 AI494296 H45380 BF221646 AI363384 BI252196 BE561288 BC053376 
    AA452452 AF479409 BG765632 BE793353 BM557522 BQ063218 BM673167 AW630016 
    BG476993 BU857808 CB122890 R71917 BM790442 AI073931 M95775 BU075681 
    BM507190 CR617581 BU157752 BC013976 AI688975 BQ083935 CA394825 BG180275 
    AI193679 BM672514 AJ271290 BE504759 BI227009 AW009652 N92307 BF724617 
    AW193906 BQ949963 AF469046 AA157884 BE222900 BM021480 CB989442 BQ787442 
    CD674111 AW027535 BM931452 BU179712 BM808120 AI694069 AI299216 CF994516 
    BE274480 BU501084 AI937168 BF689735 BM695027 BU754406 BM505227 BM565460 
    AI816284 BE794540 AI360346 BF432610 BM695453 BU077824 AI087205 BM824880 
    BM310573 AI291272 AI128231 BQ961643 NM_002415 CN482296 AI816216 BM311441 
    AI816177 AI284494 BM740625 BQ062010 BU185062 BE888301 BC022414 CB120074 
    CD676270 CD675471 BM928804 AW054836 BM743200 BE348447 AW163668 CD674818 
    CB992960 AI084213 AJ711116 BE312186 AI918101 AI091708 AA340622 BU070428 
    BG340350 BM792713 BM887899 CD108658 AA371583 AA740570 BX093983 BQ678068 
    CB127256 AI348574 AK075467 BI832039 AI768768 AI417316 AI348590 BU787927 
    BM841148 CB156328 BE206929 BU556978 BE326472 CD172285 CR606770 AW160393 
    AI553869 AI143165 CB111053 BC063525 BM051673 BQ648978 AW071866 BM128240 
    AI298814 BI966846 BX343542 BM666811 H23821 BQ069049 BM747417 BP429166 
    CA432812 BE675356 AI569755 BU786775 BQ064232 BM759059 BM850110 CA411785 
    BE791073 BU077454 AA339628 BE645161 BU789064 BG168686 BQ646350 AW468709 
    BF112251 BQ220293 BU620040 BF438989 BM699364 AV704512 BQ084139 BM511463 
    BM510629 BX333470 BQ684691 BE790554 BM687377 BQ922381 CB111707 BC000447 
    AI347489 BE796702 AI807688 BE278306 Z23063 BQ957590 BE382319 BU174305 
    BM838749 BX349504 AW246102 AI091605 BU781868 AI350332 BU145285 AI671928 
    BU857402 BI192804 AW341527 CB068312 AI261418 CD106299 CA445192 AI697884 
    CB122932 R68633 BQ279063 AI744576 BF940111 CB160659 AA295918 CB140254 
    BF111661 BU737717 BX328665 BG282075 AW006424 BQ681639 CR456373 CA418623 
    CB128882 AW058662 BM055335 AI669124 BU682534 AI869963 CB160664 BC018967 
    CB851923 BU735071 BM825455 CN484532 BM888453 BU500107 BU174015 BX378828 
    BM827193 BI086848 BE386097 BC007676 BQ652740 AI339470 CB128738 AI200226 
    CD674150 AI028497 AI702600 AI626000 BE619531 BP429201 BF973778 AI831430 
    BF792052 AI819342 AI240121 BX340620 R27396 BE621309 BQ278700 NM_030807 
    BE019440 BC007376 BF968893 BG336152 BF207148 CN484465 AI719640 BI197958 
    BI118155 AI308981 BU734848 BI160632 CB128124 BQ647472 AI215836 BM664604 
    AI760395 AA304865 AI743755 AA370526 BC051440 CB106952 CD673891 BF475875 
    CB410323 BU595497 BU787651 C04098 AI279288 AI193105 AI278569 AI223288 
    BM010532 AI702756 BM851496 BM796935 BU538576 CA437482 AI292007 BM712248 
    BE268805 BM541392 BQ015582 N40833 BG744387 BM746711 AW071672 BM849588 
    AW779104 H50429 AI279799 BQ650365 BM019214 BI224826 BX333518 AV705587 
    BE386584 BU600375 AI311642 BG475756 AI694828 AI083693 AW139208 CB959807 
    AA311908 BT007148 AA312096 BX391182 AI200435 BU599129 BG769480 BE881199 
    BQ581196 BG685630 BG104600 AA814613 AI868940 BM686545 AX747559 R27395 
    BX347887 AI354843 H20020 CD674636 AI191831 AI085922 BE392596 CF593306 
    BX329701 BF310675 BI833308 BM796596 AI864671 AI917539 BP429235 BG058579 
    BF102601 AA352598 AI091236 BI601564 BF128628 AI589691 BX391183 BI819769 
    CB961181 BM821826 BP430559 AI936457 AI694829 AA983827 AI688520 BU754550 
    AA876359 BG745033 AI074437 BG281749 CB146433 BQ011703 AI192754 CF127001 
    CB110748 AW328112 CR541651 AI369693 AW592374 BM686387 AI470121 AI479689 
    BQ549357 BX332511 CD216757 AI308986 BX349503 AI797641 CB111073 BM053128 
    AA863234 BE744850 BE397274 CB111216 AW027519 AI221389 AA299734 CB960556 
    AI571374 BG057653 AF443201 AI796755 BU741296 BM128523 BG170461 AI760355 
    BM021203 BM703102 BE389323 BG327452 BU960702 CB124648 BM555630 BQ012300 
    AI283579 BU859676 AA251135 BG436668 BM504083 BE276331 AI560428 BX371240 
    BU928031 AI184214 AI694274 AI924344 BG027436 BG702376 AI218757 AK092466 
    AI749843 BM672775 BG231931 BQ643694 BF973852 BU928874 BM672117 BP339207 
    BV199481 BM670021 BE901411 BE258468 BM766852 CB109030 CB151696 AI672745 
    BE619845 AI191583 CB125517 AI379834 N20231 BM727053 CB121553 AI553989 
    AI190725 H52405 BE255744 CR407644 BU539504 BX491228 BP375917 AI348400 
    BM423568 BI199480 CK005338 CB961164 CA338169 AI936584 BU688942 BU151191 
    BE795273 AI806435 BM796701 CB160045 BQ942463 BI517325 R34174 CB106729 
    H43579 AI435102 AI283607 BG769679 H01089 BM509625 BX385745 AI570422 
    BQ446968 AW005104 BX349750 BQ013259 BE745557 AI215754 AW161213 R66188 
    AI302171 AL598366 AI333815 AW156879 BE327076 BM793171 BG333292 AI915138 
    AI079453 BI463097 BF439521 AI810523 AW161476 BM794428 BI092306 BF438882 
    AW044101 BE264050 BM817456 AW025191 AI332690 BU602243 AA312703 AI188345 
    BG750413 CK905453 BE278711 BM705559 BE408794 BE408116 BQ021036 BM792773 
    BU617621 AK055523 BU596088 BG332793 AI090698 AI342970 CB108624 AI367412 
    AI097535 AW384484 BG113654 AI743598 AA316826 AA888149 AW469660 BM808510 
    BF060674 L10612 AI347466 BE208482 AI762932 BG749201 BM745926 BG330721 
    BX283177 AI381538 BM754129 BI224696 AI004980 BE265372 AA340294 D12379 
    BU500366 BU634019 BM795923 AI699462 H87907 AW183649 AW328111 BF035878 
    AI949246 BM791553 BE300930 AI818569 BQ025515 AA329177 BE349171 AI929100 
    AV752952 BQ652579 BE390162 AI300451 AI286009 AW157611 AW510907 AI350225 
    BG256139 AI033906 BM833753 AI333831 BI160038 BE277579 BM970254 R65649 
    BM984896 AW592118 AI590153 AA906880 BU536152 AA421707 BF219932 AA452420 
    AA493395 AI017964 BF316554 BP431258 AI040260 BU688889 CA455511 T52634 
    BM691915 BE256405 BI198477 R48515 AI190207 AA032295 BF114710 BM044121 
    AA314002 AI247423 AI868523 AI660589 CB149540 BG333242 BM687770 BP428794 
    AA804564 BU069923 AA948629 BE738612 N80939 BG105084 BF317334 AA147839 
    AW469707 AI814123 AI769467 AI936849 BX100850 AI344366 AI702741 AI168029 
    AA936466 BU598067 AA121539 AA470860 AW161897 BU594892 W69958 BE397306 
    BM825107 AI040934 BM794946 BU602136 BU070162 BI468567 AW004670 BE395428 
    H87363 CB160105 AI240040 BU599267 R97730 AA719865 BE614382 AI829626 
    BG168946 BU600539 AA150737 BI603082 BM083487 BP429918 AI239684 BE392633 
    BG331286 BE856231 AA768751 AI215846 AI762471 R64406 AA514961 BQ432198 
    BI518261 AA991309 BM798236 BM707128 AW162060 AA948630 BU600157 AI005144 
    CD676277 BU077680 AI285345 BQ879195 BP374208 R68632 AA309830 BU856952 
    AI191479 BG475821 AI708875 BE265445 AA404728 AI243142 AI636812 BU155300 
    AI369222 AA909877 BF195148 AA256146 AA340850 AA404663 AI183270 AI868771 
    BM794785 BX379546 AA890324 AI374999 BE644913 CD674110 BM687326 AJ573977 
    AW103187 AI914972 AI928829 AA905485 AI453843 AA909609 BU600652 AI816444 
    CD674774 H03322 BU598521 AI871246 AA643903 BU594540 AI435403 AW157533 
    AI313355 BU787416 W80925 BF690279 AI338223 BU849984 CF130141 BG332219 
    BF684697 BF975494 BF060675 AI688357 BM744640 BU587734 H20167 CB994322 
    AI374724 AI742007 AA906183 AA932751 AW967149 H81973 CD246305 BE514972 
    BU957817 CD047972 BG256503 AA480256 BU535301 BU595398 AA504841 AA812303 
    BU594923 AW263130 H45448 AA596017 BG330342 CB139715 BP371921 AW183821 
    BG282511 BI763496 AW170094 BE562985 CB997309 BU596922 AA973062 W58087 
    BU599553 AA559036 BE409487 BG709094 CA445027 N99435 BQ890459 W84589 
    CB963330 BE261156 CD387409 AA746033 AA197276 CD050063 AI245575 AA931682 
    AA055515 BU594843 BU528368 BU077826 AI800775 AI301984 AI268153 BI192554 
    AI125853 BU594454 CF135344 CD250263 CD049972 BU958069 AA298107 BM564390 
    AA470780 BG500346 BE268238 H20356 AW295871 BE277402 AW628768 CD176574 
    AI218906 BU600936 AA746599 BI596319 AA885822 BE261996 BQ224517 N72006 
    BE391292 AI219695 H45302 BI667319 BE909721 H64815 BI963044 AI857327 
    BU506562 BE468110 AA781516 BM055053 CD173164 BQ640372 BG029148 CD174835 
    BI762955 CD174500 AW157673 BU151627 CD248255 CF780597 BQ023559 AA961067 
    BI490625 BE796091 AA159488 BF968035 BE514637 AW272955 CK126012 R96798 
    AA251199 H01088 AA146593 AA720837 AW405873 BI759368 AA995547 BE622074 
    AA826455 BQ013288 AA122330 AW197730 BM792435 BU597233 BE387441 R67068 
    BU955028 BF679022 AA451717 AI084557 CD174502 BU595355 AA527580 AA150845 
    AW591987 BU599051 BP372303 AA603346 BI757940 AI817184 CD176118 BU587371 
    AI203496 R67718 BI490105 AW081017 BF312874 CD173794 BI544744 AA460411 
    BQ012463 AI344663 CB051619 BU594245 BM808994 CK003555 BU787695 H45991 
    AI928607 BX349502 BI758945 CD385472 AA654000 CK125947 BP352086 AW872484 
    CB993135 AA894802 BU598454 AA308706 AA939186 BE899055 CK126020 H92056 
    AI827864 AA431539 W76668 AA614774 CD050960 AA156227 AI269507 AA453329 
    CD172929 BM919518 AW629369 BQ067002 CD173957 CB990734 BQ649754 AW803188 
    AA707897 AA157572 BP382615 AA991419 AA810100 AA974537 BG337679 AI826674 
    BG761404 AA078846 BU599734 BI837198 H40095 AI184010 BM911144 AI027664 
    AI382918 CD175297 AA885695 BI759366 BF930096 BF125462 CD172593 AA045695 
    AV707022 CD248771 CB105931 BE280194 BG900535 CD174519 CD249542 CD173784 
    AA902367 R25423 CB991748 BQ920563 BE266814 AA875959 BU960358 AA573110 
    BG283369 BQ651174 BI860542 BF103565 CD249127 AA524566 BE727466 BG715675 
    AA923568 AA918219 AA076332 AI216427 BE280544 AA971384 AA987407 BU595273 
    AA927016 BU782782 AA994737 AA115515 BE264690 BE409958 AA588292 BG899679 
    BG771092 AI476653 BI755702 BI835592 AI001778 H20095 CB961929 BQ084032 
    AI393363 AA905064 AA961688 AA457623 BE727297 CD387726 BG824586 CD389444 
    AA771804 AA962395 H03321 BG419229 AI187084 BE391596 BX347886 BG272968 
    AI857302 CF130403 M25639 AI184992 AI953250 BU564326 BX389238 BI667646 
    BI763502 CB992654 BG281986 AA629272 AA961859 BG715033 N29297 BI753209 
    BI765529 AA032296 BG768454 BI115665 AA927323 BU594323 AI200386 BI601179 
    AA909191 BM856459 R34296 AA641338 CD048254 N24760 H52406 W57954 
    AA128551 AA459860 CD050834 AA278211 AA613004 AA917588 AA160691 BI834395 
    BI823606 BE894161 BG477967 CD176176 AA065010 BF127426 BU598706 AA025719 
    W84608 AA927299 R26254 BM012889 CD176327 BM918809 CA455567 BG777596 
    AW000833 BM683160 BU597599 BU588697 BF218288 BG338268 CD176689 CD173819 
    BU190489 BG770248 R73892 BU532234 AA143408 CB996799 BI753901 BQ922004 
    CD176952 BI198646 CD385068 AA577272 CD173723 AA968458 BU945106 BI517698 
    AA055516 BU500349 AI222172 BU540350 T52307 BU600740 CD250030 CD248850 
    BM738383 AA255973 BI252814 AA742472 AA887230 CD172817 AA158706 BU600961 
    AA045694 CD173111 T52384 CD174388 BF173296 CD175979 CD174897 CD176556 
    CD049352 AA527589 AA714841 AA535088 CD176245 AA523215 AA973552 N24740 
    AA128294 CD248480 BQ438886 BE379493 AA150753 AA148509 BF692430 AI216034 
    CD250134 BI086455 CB106083 N72000 BQ883653 BG150401 BU935502 H02803 
    CD048875 AA069807 AW304352 AA969077 AA714341 BE621753 BF998866 AA159446 
    BF685022 R63800 N30184 AA939051 AA459923 AA121054 AA027224 AA994385 
    H92079 BE391237 AA362290 AA988526 BU598466 BF871242 BU598794 AA804946 
    BG490405 BU588893 AA076109 W80771 BX340328 BE898401 BE264052 AA970168 
    CD048416 AA991307 H43578 BU564090 CD388036 BU963242 AI810465 BU855990 
    AA906502 BQ647218 AI291395 BE041446 BE737631 AA961974 AA027993 N57761 
    BG231430 AA147279 BG499697 BM083784 BI465245 AI677731 BI752737 W73080 
    AL038046 BQ936623 BF211639 AA983481 W69959 BM805278 AA961971 AI915687 
    H50190 BF874147 AA908363 W74201 BU506556 BG479967 BM462680 AA516016 
    AI267938 AA723423 BU600769 CD389596 BI755029 CF619138 W24701 AA860828 
    N99440 CD048800 AA953815 CD385660 BU599416 AA757752 BF030104 BQ892328 
    AW002198 BU839179 BI764461 AI498977 AW269010 BF309484 AA580010 AA897410 
    AA150889 H81972 BF431076 CD051175 AI350306 R67027 D51431 AW958016 
    AA535872 BG959772 AA912186 N57702 AA205861 AA147893 AA962548 AA156403 
    BI838257 BU603926 AA588265 BQ892826 AA908336 AI129704 CD049965 AI311399 
    BG538461 BU151053 BG826530 H50428 BI225286 AA159358 AA709182 BQ642544 
    AA961858 BU902549 AA877528 AA629271 BG758726 W16934 AA075096 W76318 
    CA455467 AA026163 BG477159 AA781675 AA187055 AI344398 AA628203 AA972004 
    BG912673 AA147232 BX370955 AA909738 AI806689 AA078847 AA156617 AA844264 
    BG613557 BG615976 BG827985 BQ054738 BU928575 BM998292 BQ674092 BG771070 
    BU597683 AI767633 AW511898 N26249 AA167451 BU945051 BF306701 BM888092 
    AA159892 AI142647 D53515 AA155650 AA938234 R71962 BF305602 BE314201 
    BE410896 AA584949 AI358183 AV753443 AA514596 AA069287 AI027662 AA927264 
    CD246564 AA610555 AA922165 AI222694 AA971757 AA992236 AA491259 AI673479 
    AA886201 AW665949 AA127849 BE295368 AA505383 H64814 H99715 AI239966 
    AI183658 BI116877 AA765733 BU597738 AA455101 AA994166 BU149497 AA888298 
    AA922178 AA919055 AA625678 BI752492 AA573141 BQ676897 N59094 BI517944 
    AI937675 AI796674 AA632302 AA878295 BE788397 BU595555 BE408744 AI470504 
    BF973923 BX328070 AI184204 AA813660 BM794134 AA157377 BQ346136 AA654144 
    AA513335 AA464286 AI539695 BU598970 BG497224 R73983 AA768220 CO248332 
    BF127833 AA071027 BG996144 AJ714590 AA935445 BP339367 AI701691 AA627655 
    BF381930 H11210 AI239548 BG260901 BX368608 AA151824 AI038885 CB997515 
    CD050521 AW182149 BF699189 BM904780 CD248995 BE736859 AA897718 AI302948 
    BU564727 BU597531 BE207421 AA521116 BE622904 BG099573 BU600449 BE387303 
    AI361194 BE262621 BU535867 BI869015 AI698827 BU535993 BF438777 AA872735 
    BQ219420 AA513426 BI224758 BP429603 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A11 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ·
    SP1:              -           -     -           -                 -                       -                             -                                       
    SP2:              -     -     -     -           -                 -                       -                             -                                       
    SP3:                                            -                 -                       -                             -                                       
    SP4:              -     -     -     -           -                 -                       -     -                       -                                       
    SP5:              -           -     -           -                 -                       -                                                                     

    ExUns: 15d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SLC2A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    SLC2A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTATGTG
    SLC2A11 Expression
    About this image


    See SLC2A11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for SLC2A11

    SOURCE GeneReport for Unigene cluster: Hs.743282

    UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
    Tissue specificity: Expressed in heart and skeletal muscle

        SABiosciences Custom PCR Arrays for SLC2A11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC2A11
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC2A11
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC2A11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for SLC2A11 gene from 3/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia SLC2A111 solute carrier family 2 (facilitated glucose transporter), more 84.03(n)
    83.43(a)
      486405  XM_543531.3  XP_543531.3 
    chicken
    (Gallus gallus)
    Aves SLC2A111 solute carrier family 2 (facilitated glucose transporter), more 67.62(n)
    63.8(a)
      427704  XM_425279.2  XP_425279.2 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5603581 solute carrier family 2, facilitated glucose transporter more 60.56(n)
    55.6(a)
      560358  XM_683764.5  XP_688856.2 


    ENSEMBL Gene Tree for SLC2A11 (if available)
    TreeFam Gene Tree for SLC2A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for SLC2A11 gene
    ENSG000002513572  SLC2A72  SLC2A52  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A42  
    SLC2A12  
    10 SIMAP similar genes for SLC2A11 using alignment to 13 protein entries:     GTR11_HUMAN (see all proteins):
    SLC2A11-a    SLC2A11-c    SLC2A9    SLC2A5    SLC2A7    SLC2A14
    SLC2A3    SLC2A1    SLC2A4    SLC2A2

    SLC2A11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/977 SNPs in SLC2A11 are shown (see all 977)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381834351,2
    --8151843(+) CACTTC/TGGCCT 2 -- us2k10--------
    rs1162690411,2
    F--8151893(+) GGCCAG/AGTTTC 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1872859541,2
    --8151936(+) GAGACA/CGGGTC 2 -- us2k10--------
    rs1428748721,2
    --8152126(+) TGCCCA/GGGCTG 2 -- us2k10--------
    rs1921020931,2
    --8152196(+) ACAGGC/TGTAAA 2 -- us2k10--------
    rs57600711,2
    C,F,A,H--8152262(+) TAAGGT/CTAAAT 2 -- us2k1 tfbs319Minor allele frequency- C:0.26NS EA NA CSA WA 2336
    rs1178807761,2
    F--8152278(+) TAAGAA/TATCTG 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1835181251,2
    --8152336(+) TCCTTC/TTTATT 2 -- us2k10--------
    rs48205701,2
    C,F,A,H--8152387(+) ggagtG/Acagtg 2 -- us2k17Minor allele frequency- A:0.36EA NA WA CSA 187
    rs1889540611,2
    C--8152395(+) GTGGCA/GCAATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC2A11 (24198890 - 24228496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for SLC2A11 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    esv1010693CNV Deletion20482838
    esv2661391CNV Deletion23128226
    esv2724065CNV Deletion23290073
    nsv3577CNV Insertion18451855
    nsv914604CNV Loss21882294
    dgv4907n71CNV Loss21882294
    dgv4908n71CNV Loss21882294
    nsv526567CNV Gain19592680
    dgv4906n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A11
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610367    OMIM disorders: --

    4 diseases for SLC2A11:    About MalaCards
    meningioma    multiple myeloma    myeloma    leukemia


    SLC2A11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): SLC2A11
    Human Genome Epidemiology (HuGE) Navigator: SLC2A11 (4 documents)

    Export disorders for SLC2A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for SLC2A11 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with SLC2A11)
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    1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PubMed id 11741323)1, 2, 9 Sasaki T.... Shimizu N. (2001)
    2. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    7. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. (PubMed id 12175779)1, 2 Wu X.... Freeze H.H. (2002)
    8. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PubMed id 16154905)1, 9 Scheepers A....Schurmann A. (2005)
    9. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PubMed id 11583593)1, 9 Doege H....Schurmann A. (2001)
    10. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PubMed id 14704796)1, 9 Gaster M....Schroder H.D. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 66035 HGNC: 14239 AceView: MIFandSLC2A11 Ensembl:ENSG00000133460 euGenes: HUgn66035
    ECgene: SLC2A11 H-InvDB: SLC2A11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for SLC2A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A11 gene:
    Search GeneIP for patents involving SLC2A11

    GeneCards and IP:
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