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SLC2A11 Gene

protein-coding   GIFtS: 50
GCID: GC22P024198

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member
111 2
     Glucose Transporter Protein 102
GLUT112 3 5     Glucose Transporter Protein 112
Glucose Transporter Type 102 3     Glucose Transporter-Like Protein XI2
Glucose Transporter Type 112 3     Solute Carrier Family 2, Facilitated Glucose Transporter Member 112
GLUT102 3     GLUT-103
Facilitative Glucose Transporter GLUT112     GLUT-113

External Ids:    HGNC: 142391   Entrez Gene: 660352   Ensembl: ENSG000001334607   OMIM: 6103675   UniProtKB: Q9BYW13   

Export aliases for SLC2A11 gene to outside databases

Previous GC identifers: GC22U990207 GC22P020895 GC22P022523 GC22P007184


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for SLC2A11 Gene:
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The
encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants.
(provided by RefSeq, Sep 2013)

GeneCards Summary for SLC2A11 Gene:
SLC2A11 (solute carrier family 2 (facilitated glucose transporter), member 11) is a protein-coding gene. GO annotations related to this gene include substrate-specific transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
Function: Facilitative glucose transporter

Gene Wiki entry for SLC2A11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the SLC2A11 gene promoter:
         NF-1   RFX1   Elk-1   p300   HTF   Lmo2   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A11 promoter sequence
   Search Chromatin IP Primers for SLC2A11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23   Ensembl cytogenetic band:  22q11.23   HGNC cytogenetic band: 22q11.23

SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A11 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024198:  view genomic region     (about GC identifiers)

Start:
24,198,890 bp from pter      End:
24,228,496 bp from pter
Size:
29,607 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1 (See protein sequence)
Recommended Name: Solute carrier family 2, facilitated glucose transporter member 11  
Size: 496 amino acids; 53703 Da
Caution: Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10
Secondary accessions: E9PH55 Q542Y4 Q6ICJ5 Q8WXF9 Q8WYM4
Alternative splicing: 4 isoforms:  Q9BYW1-1   Q9BYW1-2   Q9BYW1-3   Q9BYW1-4   

Explore the universe of human proteins at neXtProt for SLC2A11: NX_Q9BYW1

Explore proteomics data for SLC2A11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47

  • See SLC2A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020109.1  NP_001020110.1  NP_001269793.1  NP_110434.3  

    ENSEMBL proteins: 
     ENSP00000342542   ENSP00000385949   ENSP00000381399   ENSP00000384987   ENSP00000255830  
     ENSP00000403654   ENSP00000398439   ENSP00000398746   ENSP00000385156   ENSP00000326748  
    Reactome Protein details: Q9BYW1

    SLC2A11 Human Recombinant Protein Products:

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    Novus Biologicals SLC2A11 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for SLC2A11 

    SLC2A11 Antibody Products:

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    SLC2A11 Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for SLC2A11 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLC: Solute carriers

    IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 11
    Class II transporters

    5 InterPro protein domains:
     IPR005829 Sugar_transporter_CS
     IPR005828 Sub_transporter
     IPR003663 Sugar/inositol_transpt
     IPR020846 MFS_dom
     IPR016196 MFS_dom_general_subst_transpt

    Graphical View of Domain Structure for InterPro Entry Q9BYW1

    ProtoNet protein and cluster: Q9BYW1

    3 Blocks protein domains:
    IPB000803 Mammalian facilitated glucose transporter family signature
    IPB003663 Sugar transporter signature
    IPB005829 Sugar transporter superfamily


    UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
    Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose
    transporter subfamily


    Find genes that share domains with SLC2A11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GTR11_HUMAN, Q9BYW1
    Function: Facilitative glucose transporter

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022857transmembrane transporter activity ----
    GO:0022891substrate-specific transmembrane transporter activity IEA--
         
    Find genes that share ontologies with SLC2A11           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A11
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    miRNA
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    miRTarBase miRNAs that target SLC2A11:
    hsa-let-7e-5p (MIRT051456), hsa-mir-335-5p (MIRT018382)

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    GenScript: all cDNA clones in your preferred vector (see all 3): SLC2A11 (NM_001024939)
    Sino Biological Human cDNA Clone for SLC2A11
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GTR11_HUMAN, Q9BYW1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with SLC2A11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for SLC2A11 About    
    See pathways by source

    SuperPathContained pathways About
    1Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    SLC-mediated transmembrane transport0.47
    Facilitative Na+-independent glucose transporters0.00
    Transmembrane transport of small molecules0.47
    Class II GLUTs0.00
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds0.38
    2PAK Pathway
    Antioxidant Action of Vitamin-C0.56
    3HIF1Alpha Pathway
    HIF1Alpha Pathway


    Find genes that share SuperPaths with SLC2A11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A11
        Antioxidant Action of Vitamin-C
    HIF1Alpha Pathway


    1 Reactome Pathway for SLC2A11
        Class II GLUTs


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for SLC2A11
    Interactions:

        Search GeneGlobe Interaction Network for SLC2A11

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008643carbohydrate transport IEA--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with SLC2A11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for SLC2A11 (GTR11)

    2 Novoseek inferred chemical compound relationships for SLC2A11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 63.4 7 11583593 (2), 16154905 (2), 11780753 (1)
    glucose 35.7 7 11741323 (2), 14704796 (1), 11780753 (1), 11583593 (1) (see all 5)



    Find genes that share compounds with SLC2A11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for SLC2A11 gene (4 alternative transcripts): 
    NM_001024938.3  NM_001024939.3  NM_001282864.1  NM_030807.4  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000345044 ENST00000403208 ENST00000398356(uc002zym.4 uc002zyn.4 uc002zyo.4 uc011ajc.1)
    ENST00000405847 ENST00000467660 ENST00000405286 ENST00000255830 ENST00000489322
    ENST00000440493 ENST00000473740 ENST00000492516 ENST00000423972 ENST00000418102
    ENST00000491948 ENST00000436643 ENST00000405340(uc011ajd.1 uc002zyp.4)
    ENST00000461809(uc002zyl.1) ENST00000316185
    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat SLC2A11
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    GenScript: all cDNA clones in your preferred vector (see all 3): SLC2A11 (NM_001024939)
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      QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
      QuantiFast Probe-based Assays in human, mouse, rat SLC2A11

    1476 AceView cDNA sequences (see top 24):

    BQ064232 AI569755 AW005755 BM887899 CR456520 CB128882 BM824880 CA394825 
    H23821 BI192804 BF689735 CA418623 BG765632 BU781868 AA339628 AI669124 
    BM824569 BE222900 AI937168 BU857402 BC013976 BF221646 BM055335 BG476993 
    BM769836 BU787927 BQ061588 AW193906 BM699364 BF338724 BX328665 BM687377 
    R71917 AW341527 BQ684691 BC063525 BM841148 AI215687 BE790554 BU077824 
    AI299216 AW341498 BM672514 BG340350 BE504759 M95775 CB851923 CR456373 
    BM551894 BF940111 BQ063218 AI869963 BI832039 BQ681639 H44219 AI816177 
    BE888301 CA411785 BM825455 BU174015 BM311441 BC018967 AI261418 AI219290 
    AW163333 CB111707 AA028035 BU737717 BE206929 CD676270 CA432812 AI339470 
    AA740570 CD674818 CB068312 AW009548 BE794540 AA340622 AA295918 BM759059 
    CB160664 BG282075 AF479409 CB122932 AW246102 BM051673 BX343542 AI128231 
    BU075681 AI360346 BU190643 CN484532 AI091605 BU185117 BM021480 BU070428 
    BQ279063 BQ083935 BP429166 BQ084139 BQ648978 NM_002415 CR602271 CB992960 
    CB120074 BI086848 BC000447 BQ787442 BU501084 BM740625 AI816216 BE675356 
    BE794339 BX378828 CB989442 Z23063 CB160659 BX349504 AA157884 BQ069049 
    AW071866 CD108658 CD106299 BE312186 BE348447 BI227009 AI669946 AW058662 
    BM827193 BI252196 AW163668 AI918101 BE561288 CR606770 BM565460 BE386097 
    BQ957590 BM696446 BU145285 AI193679 AI697884 BF438989 BU174305 AW006424 
    BM504318 AI291272 BU077454 BM695453 AI674639 CF994516 BX093983 BM511463 
    BM666811 AI347489 BC022414 BM507190 AI336268 BE278306 AW468709 BU838070 
    BQ220293 AI744576 BF432610 BU620040 AW009652 BM747417 AJ271290 CB140254 
    BQ652740 BQ062010 CB111053 BE269667 BQ961643 H45380 R68633 BM931452 
    AI073931 N92307 BE793353 BM850110 BM128240 BM928804 BF061812 AI350332 
    AI553869 AF469046 AI143165 BQ678068 AI494296 AW160393 BE382319 AJ711116 
    BM844224 CD675471 CR617581 AA371583 BM673167 CN482296 AA721058 AA181313 
    AW027535 BM838749 AA356788 AI694069 AA452452 CB156328 AI417316 BM888453 
    BQ646350 BM792713 CD172285 BC008914 BE645161 BM695027 BF112251 BM557522 
    AI091708 BU857808 AW630016 BU754406 BF111661 AI284494 BM310573 BU179712 
    BQ922381 BU556978 BM505227 AI348574 CD674111 AI087205 AI363384 BE274480 
    BE796702 BG180275 BC007676 CB108556 BU157752 BM743200 BE326472 BU500107 
    BM808120 BF724617 CB127256 AW054836 AV704512 H46251 BU185062 BM790442 
    BQ949963 AI816284 BU682534 BU789064 BI966846 AI688975 CB122890 AI768768 
    BU786775 AI807688 BM510629 BX333470 BC053376 BE791073 CA445192 AI671928 
    AI298814 BG168686 BU735071 AI348590 AK075467 AI084213 BI160632 BE795273 
    CR407644 BM796701 BF438882 BU599129 AI215836 BG769679 BE744850 L10612 
    AI672745 CK005338 BU960702 BU741296 R27396 BP375917 BE019440 AW592374 
    AI278569 CN484465 AX747559 AI719640 AI215754 AI090698 AW044101 BQ011703 
    AI810523 BQ650365 BM019214 R27395 BG113654 AW384484 CB960556 AA312096 
    BG027436 BG336152 AA311908 BI199480 BF102601 BE881199 BQ013259 BM795923 
    CR541651 H50429 BV199481 BM745926 BG744387 R34174 BM796596 AI308986 
    BE255744 NM_030807 AI342970 BM128523 AI702756 AI688520 CB410323 AA352598 
    AI936457 BE619531 BM053128 AK055523 BM672775 BX385745 CB151696 AI760395 
    BF060674 H43579 BM423568 BG330721 BG333292 CK905453 AI868940 BX391182 
    AI367412 BE389323 BM712248 BU595497 AL598366 BF128628 CF593306 BF310675 
    AI279288 BM808510 CB124648 CB110748 BE745557 CB111073 BC051440 AI283579 
    BU151191 BM672117 CB121553 BP429201 BI819769 AI589691 BI224826 AI762932 
    BP430559 AA251135 BI517325 AI743755 AI279799 CB961181 CB160045 BX329701 
    BP339207 AW156879 BM796935 BM686545 CB109030 AI333815 AI223288 BF792052 
    AW071672 C04098 CD674150 AI004980 BG057653 CB128738 AI348400 AI292007 
    BU754550 BM021203 BX491228 CD673891 AI191583 N40833 BX332511 BG769480 
    AI193105 BF439521 BU928874 AW027519 BU600375 AI190725 BG332793 AI571374 
    H52405 AI560428 AW779104 CB111216 AI553989 BX371240 BM754129 AI936584 
    BP429235 D12379 AA299734 BE208482 BM821826 BE264050 BX347887 AI694274 
    AA340294 AI188345 AW328112 CB106729 BI601564 AI192754 AI831430 AI200435 
    BX391183 AI924344 BG170461 AI702600 AI819342 BI118155 BF968893 AI626000 
    AI074437 BU500366 BX333518 BQ446968 AI796755 BM670021 N20231 BM849588 
    BI463097 BQ015582 AI184214 BE901411 BQ012300 AI079453 H01089 BF207148 
    AI743598 AI694828 BQ643694 BG702376 AI191831 AI797641 BF973852 BG327452 
    BU928031 BE265372 AI200226 BG058579 AI332690 BU859676 BM794428 BI197958 
    AI915138 BE258468 BU734848 H20020 AI570422 BT007148 BF973778 BU539504 
    AA312703 AI379834 AI221389 CA338169 AI091236 BU596088 BE621309 AI694829 
    AW139208 BQ021036 CB146433 BI092306 BG685630 BE327076 AI097535 BI833308 
    BM766852 BG104600 BE408794 BM541392 CF127001 AF443201 BX283177 BU634019 
    AI085922 BQ647472 CD216757 BC007376 AI470121 BM686387 AA863234 BM705559 
    BU688942 CB128124 AW005104 AI240121 BE268805 AW161476 BG750413 CB961164 
    BE276331 BQ278700 AI806435 BU617621 AI917539 BE386584 BG231931 BM664604 
    AW025191 AA983827 AI308981 AI311642 BM817456 BU787651 CB959807 BM792773 
    AI864671 BE397274 BI224696 BE278711 AI381538 AA814613 AI028497 CD674636 
    BG436668 BG749201 R66188 BF475875 BQ549357 BM509625 CA437482 AW161213 
    BX349750 BM703102 BQ942463 AI283607 AK092466 AI760355 BM555630 AW469660 
    BM793171 BX340620 AI479689 AA370526 BG745033 BE408116 BM727053 CB108624 
    AI369693 BE392596 AI749843 BX349503 BM010532 AI435102 BU538576 AA888149 
    AI354843 AI083693 CB125517 BQ581196 BE619845 AI347466 AA304865 BG281749 
    AV705587 BG475756 AA316826 CB106952 BU602243 BM746711 AI302171 BM851496 
    BM504083 AI218757 AA876359 AI191479 BE390162 BI518261 BU600539 AI350225 
    AI708875 AI702741 BU598521 AW183649 AW592118 AW469707 AA329177 BM794946 
    H87907 AI868771 AA404728 AI453843 BF219932 BQ025515 AW103187 BE644913 
    BM970254 AI699462 AW157611 BG105084 BU856952 AW004670 AI936849 BE392633 
    BU600157 BI468567 BU599267 BU077680 BU594540 BF060675 AI168029 AI338223 
    BF684697 H03322 AI369222 R48515 AA804564 AI286009 CB149540 CD676277 
    AA514961 AI868523 AI333831 CD674774 BM744640 BX100850 AI215846 BM691915 
    BM083487 AW161897 AW328111 BF975494 AI435403 AA470860 BG256139 CD674110 
    BE277579 AI344366 BE856231 BE256405 BP431258 AI313355 AI005144 AA404663 
    BP374208 AI240040 BU536152 BU070162 AI816444 BE738612 AI190207 R97730 
    AI660589 AA147839 CA455511 AI829626 BP429918 AA643903 BG332219 BU587734 
    AA150737 AA768751 BF316554 AA032295 AI183270 BF035878 BI603082 BM798236 
    BE395428 BM687770 BU155300 CB160105 AI247423 BU602136 W80925 H20167 
    AA340850 BI160038 BU600652 AA909609 BE349171 BM687326 AA493395 BE300930 
    AA452420 BG331286 AW162060 AI590153 BQ652579 BM833753 AA936466 N80939 
    AI818569 AV752952 W69958 BG333242 BU598067 BU849984 AI285345 BU069923 
    BM791553 BM984896 AJ573977 AI929100 AA948629 BG475821 AA256146 BQ432198 
    BE265445 AW510907 AA909877 AA906880 AI928829 BQ879195 BI198477 AI040260 
    BF690279 BE614382 BG168946 BU688889 BF195148 BM044121 AI239684 BM794785 
    R65649 AI636812 AA948630 AI300451 AI374999 AI688357 H87363 AI871246 
    CB994322 AI769467 BX379546 BP428794 BU594892 AA905485 AI243142 BE397306 
    AA421707 BM707128 AA890324 BU787416 BM825107 AI374724 R64406 AW157533 
    AA309830 BF114710 T52634 AI914972 AA991309 R68632 BF317334 AI814123 
    AI762471 AI949246 AI040934 AA719865 AA121539 AI017964 AI033906 AA314002 
    CF130141 CB139715 AA298107 AA995547 BP352086 AW591987 CB993135 BI596319 
    AA251199 AA197276 BI758945 BE268238 CD174500 BE909721 BX349502 AA906183 
    BE261156 AI827864 AW803188 AI219695 CB963330 AA431539 BG330342 R67718 
    AW967149 CK126020 N99435 CD050063 BU599553 BE277402 BE899055 AA596017 
    AA720837 AI269507 AA470780 BQ224517 AA603346 AI301984 CF780597 BU958069 
    CD173957 CD047972 BE261996 AW405873 BI667319 BU594245 AI928607 AA480256 
    AA746599 AW170094 AA159488 AA527580 AA453329 CD176118 AA939186 AI125853 
    CD250263 AA122330 CD174502 BG256503 AA812303 AA150845 BF312874 AW629369 
    BI490105 AI800775 AW272955 BU597233 BI763496 BQ013288 BP371921 AI203496 
    AW295871 BQ890459 BM055053 AI268153 BU595398 AA055515 BI544744 CD173164 
    AI857327 BU594454 AI084557 AA614774 AA826455 AW183821 CK125947 BI762955 
    AA504841 BQ649754 H20356 H81973 BU595355 R67068 R96798 AW628768 
    CF135344 BU957817 CB990734 BQ067002 AA156227 CD248255 BU955028 W76668 
    AA460411 AI344663 W84589 H45448 BE514972 BI490625 BM564390 AA894802 
    BM792435 BQ012463 BE514637 CD049972 AA559036 BE409487 H92056 BE391292 
    BU598454 CK126012 BE387441 AA308706 BU077826 AW081017 AA961067 BG500346 
    BU600936 CD385472 BM919518 BU596922 AI245575 BQ640372 BU528368 AA932751 
    N72006 BI757940 BI192554 BU535301 AI218906 BE562985 AW872484 CD050960 
    BI963044 AA451717 BG709094 AA973062 W58087 BU787695 CD246305 AI817184 
    AW157673 AA746033 CB051619 H45991 BU506562 CD176574 H01088 AW263130 
    CA445027 BP372303 BE622074 CD174835 H45302 BU594843 CK003555 AI742007 
    AA885822 H64815 BF679022 BU587371 BM808994 AW197730 AA931682 BU151627 
    BI759368 BU599051 BG029148 AA146593 BG282511 CB997309 CD173794 BE796091 
    AA781516 CD387409 CD172929 BU594923 AA654000 BE468110 BF968035 BQ023559 
    BU598706 W57954 AA973552 AA902367 T52307 CD387726 BG715675 AA641338 
    AA629272 AI382918 BF125462 BG272968 AA968458 AI027664 BU532234 AI826674 
    BF173296 AA524566 AA991419 N24760 BI834395 BQ920563 CD049352 BU945106 
    AA045694 CD176556 AA971384 AI222172 BM918809 CD173723 BG337679 CD176689 
    CD175297 BF103565 CD249542 AA128294 AA032296 AA573110 AI187084 AW000833 
    CD248771 BE727297 AA917588 AI476653 BI667646 BM856459 CD175979 CD250030 
    BG283369 AA707897 R26254 BI601179 AA128551 AA987407 AI953250 BI823606 
    CD385068 M25639 AA961688 BE264690 AA078846 BG768454 AI393363 BI763502 
    AA771804 CF130403 AA927299 BG419229 AA885695 BI753901 BI198646 CB996799 
    AA157572 BU782782 CD172593 CD174519 BF930096 BI755702 BI517698 BG477967 
    BG761404 BI753209 BF218288 BE266814 AA065010 N24740 CB992654 AA076332 
    AV707022 BE409958 AA459860 CD176952 T52384 AI216427 BM738383 AA535088 
    AA613004 CB961929 BU600740 AA810100 AI200386 BU599734 AA160691 AA025719 
    BU564326 CD249127 AI184010 BG338268 AA045695 BM683160 AA714841 AA927323 
    BE727466 AA255973 CD176176 AA875959 CD174897 BI252814 AA905064 AA577272 
    BQ084032 BF127426 BG900535 BP382615 AA742472 BQ651174 AA278211 BU597599 
    BX389238 BE280544 AA909191 BI759366 BG777596 CD176327 BI835592 CD174388 
    AI001778 BG771092 CD248480 BI115665 H03321 BU600961 W84608 AA962395 
    BG715033 CB105931 R34296 BI837198 BG899679 AA923568 AA143408 AA457623 
    CD173111 BQ922004 BU595273 BU190489 BQ438886 BU540350 AA115515 H40095 
    CA455567 H52406 BI860542 AA918219 AA588292 R73892 AA927016 BU594323 
    BM012889 BU500349 CD172817 CB991748 AA055516 AI184992 BU960358 BE280194 
    BM911144 AA523215 CD173784 AA527589 AA974537 BU588697 BX347886 CD173819 
    CD248850 CD176245 AA158706 CD048254 CD389444 BG770248 AI857302 BI765529 
    N29297 AA994737 BE894161 BG824586 R25423 CD050834 AA961859 BE391596 
    AA887230 H20095 BG281986 BF998866 BG150401 BE379493 BE041446 AW269010 
    AA714341 AI677731 BI086455 R63800 BG490405 BE621753 H92079 AA906502 
    BU839179 AA908363 CD388036 BG499697 N57702 AI350306 W74201 AI915687 
    AA159446 W69959 BU598466 AA970168 BI465245 BU564090 BI764461 AA205861 
    AA953815 AA983481 BU600769 BI755029 AA804946 BG231430 BU598794 AI216034 
    BQ892328 BM083784 BF030104 AI267938 AA723423 AA860828 H02803 BU935502 
    AA459923 BQ647218 W73080 AA027224 BE737631 CB106083 BU599416 AA516016 
    AA897410 BQ936623 D51431 BF431076 AA069807 AW002198 CD048416 CD051175 
    AA961971 BU963242 BM805278 BG959772 AA991307 BE264052 H81972 BF309484 
    AA939051 N99440 BM462680 BF692430 BF871242 AA150753 AA757752 AA994385 
    CD048800 AI291395 H50190 BE391237 AW958016 BF874147 BI752737 W80771 
    W24701 AI498977 N30184 AA988526 BU506556 CD250134 AA362290 N57761 
    AA150889 BF211639 BG479967 AA147893 BE898401 BF685022 R67027 CD048875 
    N72000 AA027993 AA121054 AA912186 AA147279 AA969077 AA535872 BU588893 
    AW304352 CD389596 BQ883653 CD385660 BU855990 AA148509 AA076109 AA961974 
    BX340328 CF619138 AA580010 AI810465 H43578 AL038046 BE314201 AA994166 
    AA844264 AA155650 AI796674 BU149497 BU597738 BG758726 AA922178 BI517944 
    AI142647 BE410896 AA455101 AA632302 BQ892826 AA514596 AA709182 W16934 
    BI116877 AA629271 AI937675 AA877528 BM888092 AA026163 AA075096 AA159358 
    AI344398 AA971757 BU603926 AI183658 AA886201 AA588265 AW511898 BU151053 
    H50428 AI027662 AA505383 BG771070 BG826530 BI225286 AA962548 BG477159 
    BE295368 BM998292 AA922165 AA781675 D53515 CA455467 AA147232 AA888298 
    AA584949 AI673479 N59094 AA156403 AA127849 BG538461 BG912673 N26249 
    BG613557 AA961858 AA938234 BQ676897 AA625678 AA156617 AA628203 AA909738 
    BU928575 AI311399 H99715 AI239966 AI806689 AI767633 AI129704 AA992236 
    AA069287 AA927264 CD049965 AI222694 BQ674092 BI752492 AA878295 BG827985 
    AA610555 AA765733 BF305602 AA167451 BI838257 BU597683 BX370955 BQ054738 
    BU902549 AA972004 AA187055 AV753443 BG615976 BQ642544 H64814 AI358183 
    AA491259 BU945051 AA159892 R71962 AA573141 CD246564 AA078847 W76318 
    BF306701 AW665949 AA919055 AA908336 AJ714590 BP339367 AI239548 BF973923 
    AA151824 BF381930 BQ346136 BF127833 BX328070 BU595555 AA627655 BG260901 
    AA464286 BX368608 AI038885 AI539695 AA654144 BM794134 AA513335 AA768220 
    AI470504 CO248332 AI184204 CB997515 AA813660 H11210 AI701691 BG497224 
    BE408744 BE788397 AA157377 BG996144 R73983 AA935445 BU598970 AA071027 
    BI869015 BE387303 BI224758 AI302948 BE622904 BE736859 BG099573 BE207421 
    BE262621 AW182149 BU535993 BF699189 BU597531 BM904780 AA897718 AA872735 
    BF438777 BU535867 BQ219420 BU564727 AA513426 BU600449 AI698827 AI361194 
    CD050521 CD248995 BP429603 AA521116 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A11 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ·
    SP1:              -           -     -           -                 -                       -                             -                                       
    SP2:              -     -     -     -           -                 -                       -                             -                                       
    SP3:                                            -                 -                       -                             -                                       
    SP4:              -     -     -     -           -                 -                       -     -                       -                                       
    SP5:              -           -     -           -                 -                       -                                                                     

    ExUns: 15d
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for SLC2A11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    SLC2A11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGTATGTG
    SLC2A11 Expression
    About this image


    SLC2A11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    SLC2A11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    SLC2A11 Protein Expression

    UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1
    Tissue specificity: Expressed in heart and skeletal muscle

        Custom PCR Arrays for SLC2A11
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for SLC2A11
    OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat SLC2A11
    QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
    QuantiFast Probe-based Assays in human, mouse, rat SLC2A11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for SLC2A11 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia SLC2A111 solute carrier family 2 (facilitated glucose transporter), more 84.03(n)
    83.43(a)
      486405  XM_543531.4  XP_543531.4 
    chicken
    (Gallus gallus)
    Aves SLC2A111 solute carrier family 2 (facilitated glucose transporter), more 67.62(n)
    63.8(a)
      427704  XM_425279.3  XP_425279.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    many ↔ many
    GL344354.1(29825-46813)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia slc2a111 solute carrier family 2 (facilitated glucose transporter), more 62.95(n)
    60.56(a)
      100496562  XM_004910582.1  XP_004910639.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5603581 solute carrier family 2, facilitated glucose transporter more 59.3(n)
    54.34(a)
      560358  XM_683764.6  XP_688856.2 


    ENSEMBL Gene Tree for SLC2A11 (if available)
    TreeFam Gene Tree for SLC2A11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for SLC2A11 gene
    ENSG000002513572  SLC2A52  SLC2A72  SLC2A32  SLC2A92  SLC2A142  SLC2A22  SLC2A42  
    SLC2A12  
    10 SIMAP similar genes for SLC2A11 using alignment to 13 protein entries:     GTR11_HUMAN (see all proteins):
    SLC2A11-a    SLC2A11-c    SLC2A9    SLC2A5    SLC2A7    SLC2A14
    SLC2A1    SLC2A3    SLC2A4    SLC2A2

    Find genes that share paralogs with SLC2A11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for SLC2A11 (see all 977)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1381834351,2
    --8151843(+) CACTTC/TGGCCT 2 -- us2k10--------
    rs1162690411,2
    F--8151893(+) GGCCAG/AGTTTC 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1872859541,2
    --8151936(+) GAGACA/CGGGTC 2 -- us2k10--------
    rs1428748721,2
    --8152126(+) TGCCCA/GGGCTG 2 -- us2k10--------
    rs1921020931,2
    --8152196(+) ACAGGC/TGTAAA 2 -- us2k10--------
    rs57600711,2
    C,F,A,H--8152262(+) TAAGGT/CTAAAT 2 -- us2k1 tfbs319Minor allele frequency- C:0.26NS EA NA CSA WA 2336
    rs1178807761,2
    F--8152278(+) TAAGAA/TATCTG 2 -- us2k11Minor allele frequency- T:0.01EA 120
    rs1835181251,2
    --8152336(+) TCCTTC/TTTATT 2 -- us2k10--------
    rs48205701,2
    C,F,A,H--8152387(+) ggagtG/Acagtg 2 -- us2k17Minor allele frequency- A:0.36EA NA WA CSA 187
    rs1889540611,2
    C--8152395(+) GTGGCA/GCAATC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for SLC2A11 (24198890 - 24228496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for SLC2A11 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724041CNV Deletion23290073
    esv1010693CNV Deletion20482838
    esv2661391CNV Deletion23128226
    esv2724065CNV Deletion23290073
    nsv3577CNV Insertion18451855
    nsv914604CNV Loss21882294
    dgv4907n71CNV Loss21882294
    dgv4908n71CNV Loss21882294
    nsv526567CNV Gain19592680
    dgv4906n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing SLC2A11
    DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 610367    OMIM disorders: --


    Find genes that share disorders with SLC2A11           About GenesLikeMe

    Genetic Association Database (GAD): SLC2A11
    Human Genome Epidemiology (HuGE) Navigator: SLC2A11 (4 documents)

    Export disorders for SLC2A11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for SLC2A11 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with SLC2A11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PubMed id 11741323)1, 2, 9 Sasaki T.... Shimizu N. (Biochem. Biophys. Res. Commun. 2001)
    2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (Hum. Immunol. 2010)
    3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (amp 2010)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. (PubMed id 12175779)1, 2 Wu X.... Freeze H.H. (Mol. Genet. Metab. 2002)
    8. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PubMed id 16154905)1, 9 Scheepers A....SchA1rmann A. (Mol. Membr. Biol. 2005)
    9. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PubMed id 11583593)1, 9 Doege H....SchA1rmann A. (Biochem. J. 2001)
    10. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PubMed id 14704796)1, 9 Gaster M....der H.D. (Pflugers Arch. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 66035 HGNC: 14239 AceView: MIFandSLC2A11 Ensembl:ENSG00000133460 euGenes: HUgn66035
    ECgene: SLC2A11 H-InvDB: SLC2A11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for SLC2A11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for SLC2A11 gene:
    Search GeneIP for patents involving SLC2A11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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