SLC2A11 Gene

Aliases
for SLC2A11 gene

Previous GC identifers: GC22U990207 GC22P020895 GC22P022523 GC22P007184

Summaries
for SLC2A11 gene

Genomic Views
for SLC2A11 gene

RefSeq DNA sequence:

NC_000022.10  NC_018933.1  NT_011520.12  

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A11 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat SLC2A11

SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024198:  view genomic region     (about GC identifiers)

Proteins
for SLC2A11 gene

Explore the universe of human proteins at neXtProt for SLC2A11: NX_Q9BYW1

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: SLC2A11 OriGene Custom Protein Services for SLC2A11
	GenScript Custom Purified and Recombinant Proteins Services for SLC2A11
	Novus Biologicals SLC2A11 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for SLC2A11

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for SLC2A11
	GenScript Custom Superior Antibodies Services for SLC2A11
	Novus Biologicals SLC2A11 Antibody
	Search for Antibodies for SLC2A11 at Abcam
	Uscn Antibodies for SLC2A11
	ThermoFisher Antibodies for SLC2A11

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC2A11
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for SLC2A11

Protein Domains /
Families
for SLC2A11 gene

ProtoNet protein and cluster: Q9BYW1

Function
for SLC2A11 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 3): SLC2A11 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat SLC2A11
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate SLC2A11
		SwitchGear 3'UTR luciferase reporter plasmid: SLC2A11 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for SLC2A11 OriGene shRNA RFP: SLC2A11 OriGene siRNA: SLC2A11
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat SLC2A11

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC2A11

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for SLC2A11 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for SLC2A11 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SLC2A11 (NM_001024939)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC2A11
		Search LifeMap BioReagents cell lines for SLC2A11

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for SLC2A11 gene

	Super-pathway	contained gene-specific pathways
1	SLC-mediated transmembrane transport	SLC-mediated transmembrane transport 1.00 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38 Transmembrane transport of small molecules 0.50
2	Facilitative Na+-independent glucose transporters	Facilitative Na+-independent glucose transporters 1.00 Class II GLUTs 0.33
3	HIF1Alpha Pathway	HIF1Alpha Pathway 1.00
4	PAK Pathway	Antioxidant Action of Vitamin-C 0.56

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for SLC2A11

	Antioxidant Action of Vitamin-C
	HIF1Alpha Pathway

5        Reactome Pathways for SLC2A11

	SLC-mediated transmembrane transport
	Transmembrane transport of small molecules
	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
	Class II GLUTs
	Facilitative Na+-independent glucose transporters

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for SLC2A11 gene

Transcripts
for SLC2A11 gene

Expression
for SLC2A11 gene

SLC2A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGTATGTG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for SLC2A11 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat SLC2A11
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat SLC2A11

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

Orthologs
for SLC2A11 gene

Paralogs
for SLC2A11 gene

Paralogs for SLC2A11 gene

ENSG00000251357²  SLC2A5²  SLC2A7²  SLC2A3²  SLC2A9²  SLC2A14²  SLC2A2²  SLC2A1²  

SLC2A4²  

10 SIMAP similar genes for SLC2A11 using alignment to 13 protein entries:     GTR11_HUMAN (see all proteins):

SLC2A11-a    SLC2A11-c    SLC2A9    SLC2A5    SLC2A7    SLC2A14

SLC2A3    SLC2A1    SLC2A4    SLC2A2

SLC2A11 for paralogs           About GeneDecksing

Genomic Variants
for SLC2A11 gene

10/752 NCBI SNPs in SLC2A11 are shown (see all 752)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1498827401,2	C,	--	24198506(+)	AAAAA-/GAAAAA	3	--	us2k1		0	--	--	--	--
rs57600751,2	C,F,A,H,	--	24198535(+)	AAATAT/CCAGCA	3	--	us2k1		17		NS EA NA CSA WA	2330
rs733985731,2	C,	--	24198633(+)	GTTTAT/CTGATG	3	--	us2k1		2		WA	120
rs1485078361,2	C,	--	24198659(+)	ACAGA-/TTAAAG	3	--	us2k1		0	--	--	--	--
rs748750371,2		--	24198874(+)	TTCTTA/GAGGTC	3	--	us2k1		1		WA	118
rs1168584771,2	F,	--	24198929(+)	AAGTCT/CAGTTT	3	--	us2k1		1		NA	120
rs733985761,2	C,	--	24199031(+)	GGTTCG/CTCAAC	3	--	us2k1		1		WA	2
rs738790061,2	C,F,	--	24199110(+)	CGGTTC/ATCCTA	3	--	ut51 us2k1		3		WA EU	675
rs1904763771,2	C,	--	24199128(+)	TCCGCC/GAAGTC	3	--	ut51 us2k1		0	--	--	--	--
rs2019212481,2		--	24199193(+)	TCTTTA/CGGTCT	3	--	int1 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC2A11 (24198890 - 24227740 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for SLC2A11: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing SLC2A11

DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A11

Disorders / Diseases
for SLC2A11 gene

Publications
for SLC2A11 gene

PubMed articles for SLC2A11 gene, integrated from 9 sources (see all 19) (see top 10): (articles sorted by number of sources associating them with SLC2A11)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PubMed id 11741323)^{1, 2, 9} Sasaki T.... Shimizu N. (2001)
2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (2004)
5. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. (PubMed id 12175779)^{1, 2} Wu X.... Freeze H.H. (2002)
6. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PubMed id 16154905)^{1, 9} Scheepers A....Schurmann A. (2005)
7. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PubMed id 11583593)^{1, 9} Doege H....Schurmann A. (2001)
8. Multiple myeloma exhibits novel dependence on GLUT4, G LUT8, and GLUT11: implications for glucose transporter-directed therapy. (PubMed id 22452979)¹ McBrayer S.K....Shanmugam M. (2012)
9. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)¹ Han S....Kang D. (2010)
10. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)¹ Rajaraman P....Inskip P.D. (2010)
11. Common variation in genes related to innate immunity and risk of adult glioma. (PubMed id 19423540)¹ Rajaraman P....Chanock S.J. (2009)
12. A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. (PubMed id 17710649)¹ Manolescu A.R....Cheeseman C. (2007)
13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
15. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)
16. The DNA sequence of human chromosome 22. (PubMed id 10591208)² Dunham I....O'Brien K.P. (1999)
17. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PubMed id 14704796)⁹ Gaster M....Schroder H.D. (2004)

External Searches for SLC2A11 gene

Genome Databases showing SLC2A11 gene

Other Databases showing SLC2A11 gene

Specialized Databases showing SLC2A11 gene

Products
for SLC2A11 gene