SLC2A11 Gene

Aliases
for SLC2A11 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC22U990207 GC22P020895 GC22P022523 GC22P007184

Summaries
for SLC2A11 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for SLC2A11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A11 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A11

SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P024198:  view genomic region     (about GC identifiers)

Proteins
for SLC2A11 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for SLC2A11: NX_Q9BYW1

Explore proteomics data for SLC2A11 at MOPED

Post-translational modifications: 

SLC2A11 Human Recombinant Protein Products:

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SLC2A11 Assay Products:

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	antibodies-online kits for SLC2A11 (2 products)

Domains /
Families
for SLC2A11 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9BYW1

Find genes that share domains with SLC2A11           About GenesLikeMe

Function
for SLC2A11 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 2 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for SLC2A11

miRNA Products:		miRTarBase miRNAs that target SLC2A11: hsa-let-7e-5p (MIRT051456), hsa-mir-335-5p (MIRT018382)
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		SwitchGear 3'UTR luciferase reporter plasmid: SLC2A11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SLC2A11
		Predesigned siRNA for gene silencing in human, mouse, rat SLC2A11

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for SLC2A11

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		Sino Biological Human cDNA Clone for SLC2A11
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

Localization
for SLC2A11 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
plasma membrane	5

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for SLC2A11 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for SLC2A11 About     See pathways by source

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	SuperPath	Contained pathways About
1	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	SLC-mediated transmembrane transport 0.47 Facilitative Na+-independent glucose transporters 0.00 Transmembrane transport of small molecules 0.47 Class II GLUTs 0.00 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds 0.38
2	PAK Pathway	Antioxidant Action of Vitamin-C 0.56
3	HIF1Alpha Pathway	HIF1Alpha Pathway

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A11

	Antioxidant Action of Vitamin-C
	HIF1Alpha Pathway

1 Reactome Pathway for SLC2A11

Class II GLUTs

Gene Ontology (GO): 2 biological process terms:    About this table

Drugs & Compounds
for SLC2A11 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for SLC2A11 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for SLC2A11 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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SLC2A11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGTATGTG

About this image

Blood (Hematopoietic System)
Granulocytes Peripheral Blood
Placenta (Extraembryonic Tissues)

Primer Products:		OriGene qPCR primer pairs and template standards for SLC2A11 OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

Orthologs
for SLC2A11 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for SLC2A11 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for SLC2A11 gene

ENSG00000251357²  SLC2A5²  SLC2A7²  SLC2A3²  SLC2A9²  SLC2A14²  SLC2A2²  SLC2A4²  

SLC2A1²  

10 SIMAP similar genes for SLC2A11 using alignment to 13 protein entries:     GTR11_HUMAN (see all proteins):

SLC2A11-a    SLC2A11-c    SLC2A9    SLC2A5    SLC2A7    SLC2A14

SLC2A1    SLC2A3    SLC2A4    SLC2A2

Find genes that share paralogs with SLC2A11           About GenesLikeMe

Genomic Variants
for SLC2A11 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for SLC2A11 (see all 977)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1381834351,2		--	8151843(+)	CACTTC/TGGCCT	2	--	us2k1		0	--	--	--	--
rs1162690411,2	F	--	8151893(+)	GGCCAG/AGTTTC	2	--	us2k1		1		WA	118
rs1872859541,2		--	8151936(+)	GAGACA/CGGGTC	2	--	us2k1		0	--	--	--	--
rs1428748721,2		--	8152126(+)	TGCCCA/GGGCTG	2	--	us2k1		0	--	--	--	--
rs1921020931,2		--	8152196(+)	ACAGGC/TGTAAA	2	--	us2k1		0	--	--	--	--
rs57600711,2	C,F,A,H	--	8152262(+)	TAAGGT/CTAAAT	2	--	us2k1 tfbs3		19		NS EA NA CSA WA	2336
rs1178807761,2	F	--	8152278(+)	TAAGAA/TATCTG	2	--	us2k1		1		EA	120
rs1835181251,2		--	8152336(+)	TCCTTC/TTTATT	2	--	us2k1		0	--	--	--	--
rs48205701,2	C,F,A,H	--	8152387(+)	ggagtG/Acagtg	2	--	us2k1		7		EA NA WA CSA	187
rs1889540611,2	C	--	8152395(+)	GTGGCA/GCAATC	2	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC2A11 (24198890 - 24228496 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for SLC2A11 (see all 14):    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2724041	CNV	Deletion	23290073
esv1010693	CNV	Deletion	20482838
esv2661391	CNV	Deletion	23128226
esv2724065	CNV	Deletion	23290073
nsv3577	CNV	Insertion	18451855
nsv914604	CNV	Loss	21882294
dgv4907n71	CNV	Loss	21882294
dgv4908n71	CNV	Loss	21882294
nsv526567	CNV	Gain	19592680
dgv4906n71	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SLC2A11

DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A11

Disorders / Diseases
for SLC2A11 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for SLC2A11 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for SLC2A11 gene, integrated from 10 sources (see all 21): (articles sorted by number of sources associating them with SLC2A11)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PubMed id 11741323)^{1, 2, 9} Sasaki T.... Shimizu N. (Biochem. Biophys. Res. Commun. 2001)
2. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
3. Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (DNA Res. 2005)
5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
7. Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. (PubMed id 12175779)^{1, 2} Wu X.... Freeze H.H. (Mol. Genet. Metab. 2002)
8. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PubMed id 16154905)^{1, 9} Scheepers A....SchA1rmann A. (Mol. Membr. Biol. 2005)
9. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PubMed id 11583593)^{1, 9} Doege H....SchA1rmann A. (Biochem. J. 2001)
10. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PubMed id 14704796)^{1, 9} Gaster M....der H.D. (Pflugers Arch. 2004)

External Searches for SLC2A11 gene

Genome Databases showing SLC2A11 gene

Other Databases showing SLC2A11 gene

Specialized Databases showing SLC2A11 gene

Products
for SLC2A11 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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