Aliases for SLC2A11 Gene
Aliases for SLC2A11 Gene
External Ids for SLC2A11 Gene
- HGNC: 14239
- Entrez Gene: 66035
- Ensembl: ENSG00000133460
- OMIM: 610367
- UniProtKB: Q9BYW1
Previous GeneCards Identifiers for SLC2A11 Gene
- GC22U990207
- GC22P020895
- GC22P022523
- GC22P024198
- GC22P007184
Summaries for SLC2A11 Gene
-
This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for SLC2A11 Gene
SLC2A11 (Solute Carrier Family 2 Member 11) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A7.
UniProtKB/Swiss-Prot for SLC2A11 Gene
-
Facilitative glucose transporter.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A11 Gene
Genomics for SLC2A11 Gene
Regulatory Elements for SLC2A11 Gene
Enhancers for SLC2A11 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around SLC2A11 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the SLC2A11 gene promoter:
Regulatory Element Products
Genomic Location for SLC2A11 Gene
- Chromosome:
- 22
- Start:
- 23,856,703 bp from pter
- End:
- 23,886,309 bp from pter
- Size:
- 29,607 bases
- Orientation:
- Plus strand
Genomic View for SLC2A11 Gene
Genes around SLC2A11 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.23 by Ensembl
- 22q11.23 by Entrez Gene
- 22q11.23 by HGNC
SLC2A11 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for SLC2A11 Gene
Proteins for SLC2A11 Gene
-
Protein details for SLC2A11 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9BYW1-GTR11_HUMAN
- Recommended name:
- Solute carrier family 2, facilitated glucose transporter member 11
- Protein Accession:
- Q9BYW1
- E9PH55
- Q542Y4
- Q6ICJ5
- Q8WXF9
- Q8WYM4
Protein attributes for SLC2A11 Gene
- Size:
- 496 amino acids
- Molecular mass:
- 53703 Da
- Quaternary structure:
- No Data Available
Protein Expression for SLC2A11 Gene
Post-translational modifications for SLC2A11 Gene
Other Protein References for SLC2A11 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for SLC2A11
- Novus Biologicals Antibodies for SLC2A11
- Invitrogen Antibodies for SLC2A11
- antibodies-online Antibodies for SLC2A11: See all 4
- GeneTex Foxs1 antibody for SLC2A11
Protein Products
-
OriGene Purified Proteins for SLC2A11
- Search Origene for MassSpec and Protein Over-expression Lysates for SLC2A11
- Origene Custom Protein Services for SLC2A11
- Search GeneTex for Proteins for SLC2A11
Assay Products
No data available for DME Specific Peptides for SLC2A11 Gene
Domains & Families for SLC2A11 Gene
Gene Families for SLC2A11 Gene
- HGNC:
- IUPHAR :
Protein Domains for SLC2A11 Gene
Suggested Antigen Peptide Sequences for SLC2A11 Gene
Graphical View of Domain Structure for InterPro Entry
Q9BYW1UniProtKB/Swiss-Prot:
GTR11_HUMAN :- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
- Family:
-
- Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Function for SLC2A11 Gene
Molecular function for SLC2A11 Gene
- UniProtKB/Swiss-Prot Function:
- Facilitative glucose transporter.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0022857 | transmembrane transporter activity | IEA | -- |
| GO:0022891 | substrate-specific transmembrane transporter activity | IEA | -- |
| GO:0051119 | sugar transmembrane transporter activity | TAS | -- |
Phenotypes for SLC2A11 Gene
- GenomeRNAi human phenotypes for SLC2A11:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC2A11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC2A11 gene
- Search ViGene Biosciences for SLC2A11
CRISPR Products
-
OriGene CRISPR knockouts for SLC2A11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A11
- GenScript: Design CRISPR guide RNA sequences for SLC2A11
miRNA for SLC2A11 Gene
- miRTarBase miRNAs that target SLC2A11
-
- hsa-mir-335-5p (MIRT018382)
- hsa-let-7e-5p (MIRT051456)
- hsa-mir-3157-5p (MIRT684668)
- hsa-mir-7151-3p (MIRT684669)
- hsa-mir-5095 (MIRT684670)
- hsa-mir-4711-5p (MIRT684671)
- hsa-mir-4691-3p (MIRT684672)
- hsa-mir-6765-3p (MIRT684673)
- hsa-mir-3622b-3p (MIRT684674)
- hsa-mir-3622a-3p (MIRT684675)
- hsa-mir-6504-3p (MIRT684676)
- hsa-mir-4438 (MIRT684677)
- hsa-mir-3606-3p (MIRT713996)
- hsa-mir-653-3p (MIRT713997)
- hsa-mir-4420 (MIRT713998)
- hsa-mir-181b-3p (MIRT713999)
- hsa-mir-181b-2-3p (MIRT714000)
- hsa-mir-5189-3p (MIRT714001)
- hsa-mir-4742-3p (MIRT714002)
- hsa-mir-6890-3p (MIRT714003)
- hsa-mir-649 (MIRT714004)
miRNA Products
- Search ViGene Biosciences for SLC2A11
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for SLC2A11
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-
ViGene Biosciences ready-to-package AAV shRNAs for SLC2A11 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC2A11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
Horizon Cell Lines for SLC2A11
-
ViGene Biosciences adenoviral particle packaged cDNA for SLC2A11 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for SLC2A11 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC2A11 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A11 Gene
Localization for SLC2A11 Gene
Subcellular locations from UniProtKB/Swiss-Prot for SLC2A11 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030054 | cell junction | IDA | -- |
Pathways & Interactions for SLC2A11 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
.01
|
|
| 2 | PAK Pathway | ||
| 3 | HIF1Alpha Pathway | ||
| 4 | NRF2 pathway | ||
Pathways by source for SLC2A11 Gene
1 BioSystems pathway for SLC2A11 Gene
2 Qiagen pathways for SLC2A11 Gene
Interacting Proteins for SLC2A11 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006810 | transport | IEA | -- |
| GO:0008643 | carbohydrate transport | IEA | -- |
| GO:0034219 | carbohydrate transmembrane transport | IEA | -- |
| GO:0055085 | transmembrane transport | IEA | -- |
No data available for SIGNOR curated interactions for SLC2A11 Gene
Drugs & Compounds for SLC2A11 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Fludeoxyglucose F-18 | Approved | Pharma | Transporter, substrate | 0 |
Transcripts for SLC2A11 Gene
mRNA/cDNA for SLC2A11 Gene
- (4) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (1476) Selected AceView cDNA sequences:
- (23) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for SLC2A11 Gene
CRISPR Products
-
OriGene CRISPR knockouts for SLC2A11
-
Santa Cruz Biotechnology (SCBT) CRISPR for SLC2A11
- GenScript: Design CRISPR guide RNA sequences for SLC2A11
miRNA Products
- Search ViGene Biosciences for SLC2A11
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for SLC2A11
- Browse OriGene Inhibitory RNA Products For SLC2A11
-
ViGene Biosciences ready-to-package AAV shRNAs for SLC2A11 gene
Clone Products
- Sino Biological Human cDNA Clone for SLC2A11
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - |
| ExUns: | 15d |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: | |
| SP10: | |
| SP11: | |
| SP12: |
Expression for SLC2A11 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Placenta (Extraembryonic Tissues)
This gene is overexpressed in Retina (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A11 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of SLC2A11 Gene:
SLC2A11SOURCE GeneReport for Unigene cluster for SLC2A11 Gene:
Hs.743282mRNA Expression by UniProt/SwissProt for SLC2A11 Gene:
Q9BYW1-GTR11_HUMAN
Tissue specificity:
Expressed in heart and skeletal muscle.
Evidence on tissue expression from TISSUES for SLC2A11 Gene
- Heart(4.2)
- Nervous system(4.2)
- Kidney(3)
- Lung(2.5)
- Pancreas(2.4)
Primer Products
-
OriGene qPCR primer pairs and template standards for SLC2A11
-
OriGene qPCR primer pairs for SLC2A11
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A11 Gene
Orthologs for SLC2A11 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | SLC2A11 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | SLC2A11 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | SLC2A11 34 35 |
|
||
| chicken (Gallus gallus) |
Aves | SLC2A11 34 |
|
||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | slc2a11 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC560358 34 |
|
||
| slc2a11b 35 |
|
ManyToMany |
- Species where no ortholog for SLC2A11 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for SLC2A11 Gene
Paralogs for SLC2A11 Gene
(10) SIMAP similar genes for SLC2A11 Gene using alignment to 13 proteins:
Variants for SLC2A11 Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000011946 | -- | 23,871,603(+) | CGGGC(A/G)TGGTG | intron-variant | |
| rs1000094916 | -- | 23,858,295(+) | GATCA(G/T)CCCTG | intron-variant | |
| rs1000246526 | -- | 23,864,619(+) | TATTT(A/G)TTCAT | intron-variant | |
| rs1000274473 | -- | 23,884,362(+) | TGCCT(A/G)CATGG | nc-transcript-variant, reference, missense | |
| rs1000338510 | -- | 23,866,791(+) | TATGT(A/G)CCTGT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1298e212 | CNV | loss | 25503493 |
| dgv1300e212 | CNV | gain | 25503493 |
| dgv1301e212 | CNV | gain | 25503493 |
| dgv4528n100 | CNV | gain | 25217958 |
| dgv4531n100 | CNV | gain | 25217958 |
| dgv8039n54 | CNV | gain | 21841781 |
| esv1010693 | CNV | deletion | 20482838 |
| esv2661391 | CNV | deletion | 23128226 |
| esv2724041 | CNV | deletion | 23290073 |
| esv2724065 | CNV | deletion | 23290073 |
| esv3575443 | CNV | gain | 25503493 |
| esv3575444 | CNV | gain | 25503493 |
| esv3575445 | CNV | gain | 25503493 |
| esv3893457 | CNV | gain | 25118596 |
| esv3893461 | CNV | gain | 25118596 |
| nsv1062411 | CNV | gain | 25217958 |
| nsv1066891 | CNV | gain | 25217958 |
| nsv1110863 | OTHER | inversion | 24896259 |
| nsv1143028 | CNV | tandem duplication | 24896259 |
| nsv3577 | CNV | insertion | 18451855 |
| nsv511075 | OTHER | complex | 20534489 |
| nsv526567 | CNV | gain | 19592680 |
| nsv588647 | CNV | gain | 21841781 |
| nsv7350 | OTHER | inversion | 18451855 |
| nsv834155 | CNV | gain+loss | 17160897 |
Residual Variation Intolerance Score:
92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.47;
85.76% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for SLC2A11 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- SLC2A11
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A11 Gene
Disorders for SLC2A11 Gene
Relevant External Links for SLC2A11
No disorders were found for SLC2A11 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A11 Gene
Publications for SLC2A11 Gene
- Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PMID: 11741323) Sasaki T. … Shimizu N. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
- Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P. … Inskip P.D. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 46 64
- Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S. … Kang D. (Hum. Immunol. 2010) 3 46 64
- Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PMID: 16154905) Scheepers A. … SchA1rmann A. (Mol. Membr. Biol. 2005) 3 22 64
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
Products for SLC2A11 Gene
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- Novus Biologicals Antibodies for SLC2A11
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- ViGene Biosciences adenoviral particle packaged cDNA for SLC2A11 gene
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- Horizon Cell Lines for SLC2A11
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- VectorBuilder custom plasmid, inducible vectors for SLC2A11
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for SLC2A11 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
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