Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms of Use
- Terms of Use
- 3rd Party Notice
About Us
- GeneCards Team
- Our Publications
- Citing GeneCards
- Licensing Agreement
- Weizmann Institute
- LifeMap Sciences Inc
User Feedback
GeneCards Plus
- Premium Tools
  
  Learn more

Set Analyses:

VarElect

Advanced Search

SLC2A11 Gene

protein-coding GIFtS: 50
GCID: GC22P024198

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

See related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

TryGeneCards Plus

Aliases
Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 11¹ ²		Glucose Transporter Protein 10²
GLUT11² ³ ⁵		Glucose Transporter Protein 11²
Glucose Transporter Type 10² ³		Glucose Transporter-Like Protein XI²
Glucose Transporter Type 11² ³		Solute Carrier Family 2, Facilitated Glucose Transporter Member 11²
GLUT10² ³		GLUT-10³
Facilitative Glucose Transporter GLUT11²		GLUT-11³

External Ids:	HGNC: 14239¹	Entrez Gene: 66035²	Ensembl: ENSG00000133460⁷	OMIM: 610367⁵	UniProtKB: Q9BYW1³

Export aliases for SLC2A11 gene to outside databases

Previous GC identifers: GC22U990207 GC22P020895 GC22P022523 GC22P007184

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for SLC2A11 Gene:

This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The

encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants.

(provided by RefSeq, Sep 2013)

GeneCards Summary for SLC2A11 Gene:

SLC2A11 (solute carrier family 2 (facilitated glucose transporter), member 11) is a protein-coding gene. Diseases associated with SLC2A11 include childhood leukemia, and meningioma. GO annotations related to this gene include substrate-specific transmembrane transporter activity. An important paralog of this gene is ENSG00000251357.

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1

Function: Facilitative glucose transporter

Gene Wiki entry for SLC2A11 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus

Regulatory elements:

Regulatory transcription factor binding sites in the SLC2A11 gene promoter:
NF-1 RFX1 Elk-1 p300 HTF Lmo2 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): SLC2A11 promoter sequence

Search Chromatin IP Primers for SLC2A11

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A11

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.23 Ensembl cytogenetic band: 22q11.23 HGNC cytogenetic band: 22q11.23

SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
SLC2A11 gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P024198: view genomic region (about GC identifiers)

Start:	24,198,890 bp from pter	End:	24,228,496 bp from pter
Size:	29,607 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1 (See protein sequence)

Recommended Name: Solute carrier family 2, facilitated glucose transporter member 11

Size: 496 amino acids; 53703 Da

Caution: Has been described as GLUT10 in literature, but this gene name has already been used for SLC2A10

Secondary accessions: E9PH55 Q542Y4 Q6ICJ5 Q8WXF9 Q8WYM4

Alternative splicing: 4 isoforms: Q9BYW1-1 Q9BYW1-2 Q9BYW1-3 Q9BYW1-4

Explore the universe of human proteins at neXtProt for SLC2A11: NX_Q9BYW1

Explore proteomics data for SLC2A11 at MOPED

Post-translational modifications:

Glycosylation² at Asn47

See SLC2A11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (4 alternative transcripts):

NP_001020109.1 NP_001020110.1 NP_001269793.1 NP_110434.3

ENSEMBL proteins:

ENSP00000342542 ENSP00000385949 ENSP00000381399 ENSP00000384987 ENSP00000255830

ENSP00000403654 ENSP00000398439 ENSP00000398746 ENSP00000385156 ENSP00000326748

Reactome Protein details: Q9BYW1

SLC2A11 Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate for SLC2A11 OriGene Custom MassSpec OriGene Custom Protein Services for SLC2A11
	GenScript Custom Purified and Recombinant Proteins Services for SLC2A11
	Novus Biologicals SLC2A11 Lysate
	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Cloud-Clone Corp.

SLC2A11 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies for SLC2A11 OriGene Custom Antibody Services for SLC2A11
	Novus Biologicals SLC2A11 Antibody
	Search for Antibodies for SLC2A11 at Abcam
	Browse Antibodies at Cloud-Clone Corp.
	ThermoFisher Antibodies for SLC2A11
	LSBio Antibodies in human, mouse, rat for SLC2A11

SLC2A11 Assay Products:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Assay Services for SLC2A11
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for SLC2A11
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TryGeneCards Plus

HGNC Gene Families:

SLC: Solute carriers

IUPHAR Guide to PHARMACOLOGY protein family classification: Glucose transporter 11

Class II transporters

5 InterPro protein domains:

IPR005829 Sugar_transporter_CS

IPR005828 Sub_transporter

IPR003663 Sugar/inositol_transpt

IPR020846 MFS_dom

IPR016196 MFS_dom_general_subst_transpt

Graphical View of Domain Structure for InterPro Entry Q9BYW1

ProtoNet protein and cluster: Q9BYW1

3 Blocks protein domains:

IPB000803 Mammalian facilitated glucose transporter family signature

IPB003663 Sugar transporter signature

IPB005829 Sugar transporter superfamily

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose

transporter subfamily

SLC2A11 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Molecular Function:

UniProtKB/Swiss-Prot Summary: GTR11_HUMAN, Q9BYW1

Function: Facilitative glucose transporter

Gene Ontology (GO): 2 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0022857	transmembrane transporter activity	--	--
GO:0022891	substrate-specific transmembrane transporter activity	IEA	--

SLC2A11 for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A11

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A11

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for SLC2A11

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for SLC2A11

miRNA Products:		miRTarBase miRNAs that target SLC2A11: hsa-let-7e-5p (MIRT051456), hsa-mir-335-5p (MIRT018382)

		Block miRNA regulation of human, mouse, rat SLC2A11 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate SLC2A11
		SwitchGear 3'UTR luciferase reporter plasmid: SLC2A11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SLC2A11
		Predesigned siRNA for gene silencing in human, mouse, rat SLC2A11

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for SLC2A11

Clone Products:		OriGene clones in human, mouse for SLC2A11 (see all 18) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SLC2A11 (NM_001024939)
		Sino Biological Human cDNA Clone for SLC2A11
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A11

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for SLC2A11
		Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A11

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
About This Section

TryGeneCards Plus

Subcellular locations from UniProtKB/Swiss-Prot

GTR11_HUMAN, Q9BYW1: Cell membrane; Multi-pass membrane protein

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	5

About this image

Gene Ontology (GO): 3 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016020	membrane	--	--
GO:0016021	integral component of membrane	IEA	--

SLC2A11 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
About This Section

TryGeneCards Plus

SuperPaths for SLC2A11 About

See pathways by source

SuperPath

Contained pathways About

Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

SLC-mediated transmembrane transport	0.47	Facilitative Na+-independent glucose transporters	0.00
Transmembrane transport of small molecules	0.47	Class II GLUTs	0.00
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	0.38

PAK Pathway

Antioxidant Action of Vitamin-C

0.56

HIF1Alpha Pathway

HIF1Alpha Pathway

Pathways by source See SuperPaths
Show all pathways

2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for SLC2A11

	Antioxidant Action of Vitamin-C
	HIF1Alpha Pathway

1 Reactome Pathway for SLC2A11

Class II GLUTs

SLC2A11 for pathways About GeneDecksing

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for SLC2A11
Interactions:

Search GeneGlobe Interaction Network for SLC2A11

Gene Ontology (GO): 2 biological process terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008643	carbohydrate transport	IEA	--
GO:0055085	transmembrane transport	TAS	--

SLC2A11 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
About This Section

TryGeneCards Plus

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Browse Tocris compounds for SLC2A11 (GTR11)

2 Novoseek inferred chemical compound relationships for SLC2A11 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose	63.4	7	11583593 (2), 16154905 (2), 11780753 (1)
glucose	35.7	7	11741323 (2), 14704796 (1), 11780753 (1), 11583593 (1) (see all 5)

SLC2A11 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
About This Section

TryGeneCards Plus

REFSEQ mRNAs for SLC2A11 gene (4 alternative transcripts):

NM_001024938.3 NM_001024939.3 NM_001282864.1 NM_030807.4

Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000345044 ENST00000403208 ENST00000398356(uc002zym.4 uc002zyn.4 uc002zyo.4 uc011ajc.1)

ENST00000405847 ENST00000467660 ENST00000405286 ENST00000255830 ENST00000489322

ENST00000440493 ENST00000473740 ENST00000492516 ENST00000423972 ENST00000418102

ENST00000491948 ENST00000436643 ENST00000405340(uc011ajd.1 uc002zyp.4)

ENST00000461809(uc002zyl.1) ENST00000316185

miRNA Products:		Block miRNA regulation of human, mouse, rat SLC2A11 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate SLC2A11
		SwitchGear 3'UTR luciferase reporter plasmid: SLC2A11 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for SLC2A11
		Predesigned siRNA for gene silencing in human, mouse, rat SLC2A11

Clone Products:		OriGene clones in human, mouse for SLC2A11 (see all 18) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): SLC2A11 (NM_001024939)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for SLC2A11
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A11

Primer Products:		OriGene qPCR primer pairs and template standards for SLC2A11 OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat SLC2A11
		QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
		QuantiFast Probe-based Assays in human, mouse, rat SLC2A11

Selected AceView cDNA sequences (see all 1476):

BQ064232 AI569755 AW005755 BM887899 CR456520 CB128882 BM824880 CA394825

H23821 BI192804 BF689735 CA418623 BG765632 BU781868 AA339628 AI669124

BM824569 BE222900 AI937168 BU857402 BC013976 BF221646 BM055335 BG476993

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A11 (see all 12) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15a	·	15b	·	15c	·
SP1:					-				-		-				-						-								-										-
SP2:					-		-		-		-				-						-								-										-
SP3:															-						-								-										-
SP4:					-		-		-		-				-						-								-		-								-
SP5:					-				-		-				-						-								-

ExUns:	15d
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for SLC2A11

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TryGeneCards Plus

SLC2A11 expression in normal human tissues (normalized intensities) SLC2A11 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGTATGTG

About this image

SLC2A11 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 2) fully expand


Blood (Hematopoietic System)
Granulocytes Peripheral Blood

Placenta (Extraembryonic Tissues)

SLC2A11 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

SLC2A11 Protein Expression

UniProtKB/Swiss-Prot: GTR11_HUMAN, Q9BYW1

Tissue specificity: Expressed in heart and skeletal muscle

Custom PCR Arrays for SLC2A11

Primer Products:		OriGene qPCR primer pairs and template standards for SLC2A11 OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11
		Pre-validated RT² qPCR Primer Assay in human, mouse / rat SLC2A11
		QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
		QuantiFast Probe-based Assays in human, mouse, rat SLC2A11

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

TryGeneCards Plus

This gene was present in the common ancestor of chordates.

Orthologs for SLC2A11 gene from Selected species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
dog (Canis familiaris)	Mammalia	SLC2A11¹	solute carrier family 2 (facilitated glucose transporter), member 11 less	84.03(n) 83.43(a)		486405 XM_543531.4 XP_543531.4
chicken (Gallus gallus)	Aves	SLC2A11¹	solute carrier family 2 (facilitated glucose transporter), member 11 less	67.62(n) 63.8(a)		427704 XM_425279.3 XP_425279.2
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	37(a)	many ↔ many	GL344354.1(29825-46813)
tropical clawed frog (Xenopus tropicalis)	Amphibia	slc2a11¹	solute carrier family 2 (facilitated glucose transporter), member 11 less	62.95(n) 60.56(a)		100496562 XM_004910582.1 XP_004910639.1
zebrafish (Danio rerio)	Actinopterygii	LOC560358¹	solute carrier family 2, facilitated glucose transporter member 11-like less	59.3(n) 54.34(a)		560358 XM_683764.6 XP_688856.2

ENSEMBL Gene Tree for SLC2A11 (if available)
TreeFam Gene Tree for SLC2A11 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

TryGeneCards Plus

Paralogs for SLC2A11 gene

ENSG00000251357² SLC2A5² SLC2A7² SLC2A3² SLC2A9² SLC2A14² SLC2A2² SLC2A4²

SLC2A1²

10 SIMAP similar genes for SLC2A11 using alignment to 13 protein entries: GTR11_HUMAN (see all proteins):

SLC2A11-a SLC2A11-c SLC2A9 SLC2A5 SLC2A7 SLC2A14

SLC2A1 SLC2A3 SLC2A4 SLC2A2

SLC2A11 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

TryGeneCards Plus

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138183435^1,2		--	8151843(+)	`CACTTC/TGGCCT`	2	--	us2k¹		0	--	--	--	--
rs116269041^1,2	F	--	8151893(+)	`GGCCAG/AGTTTC`	2	--	us2k¹		1		WA	118
rs187285954^1,2		--	8151936(+)	`GAGACA/CGGGTC`	2	--	us2k¹		0	--	--	--	--
rs142874872^1,2		--	8152126(+)	`TGCCCA/GGGCTG`	2	--	us2k¹		0	--	--	--	--
rs192102093^1,2		--	8152196(+)	`ACAGGC/TGTAAA`	2	--	us2k¹		0	--	--	--	--
rs5760071^1,2	C,F,A,H	--	8152262(+)	`TAAGGT/CTAAAT`	2	--	us2k¹ tfbs³		19		NS EA NA CSA WA	2336
rs117880776^1,2	F	--	8152278(+)	`TAAGAA/TATCTG`	2	--	us2k¹		1		EA	120
rs183518125^1,2		--	8152336(+)	`TCCTTC/TTTATT`	2	--	us2k¹		0	--	--	--	--
rs4820570^1,2	C,F,A,H	--	8152387(+)	`ggagtG/Acagtg`	2	--	us2k¹		7		EA NA WA CSA	187
rs188954061^1,2	C	--	8152395(+)	`GTGGCA/GCAATC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for SLC2A11 (24198890 - 24228496 bp)

Structural Variations
Database of Genomic Variants (DGV) Selected variations for SLC2A11 (see all 14): About this table

Variant ID	Type	Subtype	PubMed ID
esv2724041	CNV	Deletion	23290073
esv1010693	CNV	Deletion	20482838
esv2661391	CNV	Deletion	23128226
esv2724065	CNV	Deletion	23290073
nsv3577	CNV	Insertion	18451855
nsv914604	CNV	Loss	21882294
dgv4907n71	CNV	Loss	21882294
dgv4908n71	CNV	Loss	21882294
nsv526567	CNV	Gain	19592680
dgv4906n71	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing SLC2A11

DNA2.0 Custom Variant and Variant Library Synthesis for SLC2A11

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TryGeneCards Plus

OMIM gene information: 610367 OMIM disorders: --

5 diseases for SLC2A11: About MalaCards

childhood leukemia meningioma multiple myeloma myeloma

leukemia

SLC2A11 for disorders About GeneDecksing

Genetic Association Database (GAD): SLC2A11
Human Genome Epidemiology (HuGE) Navigator: SLC2A11 (4 documents)

Export disorders for SLC2A11 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

TryGeneCards Plus

PubMed articles for SLC2A11 gene, integrated from 10 sources (see all 21):
(articles sorted by number of sources associating them with SLC2A11)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PubMed id 11741323)^{1, 2, 9} Sasaki T.... Shimizu N. (Biochem. Biophys. Res. Commun. 2001)
Polymorphisms in innate immunity genes and risk of childhood leukemia. (PubMed id 20438785)^{1, 4} Han S....Kang D. (Hum. Immunol. 2010)
Risk of meningioma and common variation in genes related to innate immunity. (PubMed id 20406964)^{1, 4} Rajaraman P....Inskip P.D. (amp 2010)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (DNA Res. 2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{1, 2} Collins J.E.... Dunham I. (Genome Biol. 2004)
Cloning and characterization of glucose transporter 11, a novel sugar transporter that is alternatively spliced in various tissues. (PubMed id 12175779)^{1, 2} Wu X.... Freeze H.H. (Mol. Genet. Metab. 2002)
Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PubMed id 16154905)^{1, 9} Scheepers A....SchA1rmann A. (Mol. Membr. Biol. 2005)
Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PubMed id 11583593)^{1, 9} Doege H....SchA1rmann A. (Biochem. J. 2001)
GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PubMed id 14704796)^{1, 9} Gaster M....der H.D. (Pflugers Arch. 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

TryGeneCards Plus

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

TryGeneCards Plus

Entrez Gene: 66035	HGNC: 14239	AceView: MIFandSLC2A11	Ensembl:ENSG00000133460	euGenes: HUgn66035
ECgene: SLC2A11	H-InvDB: SLC2A11

(According to HUGE)
About This Section

TryGeneCards Plus

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

TryGeneCards Plus

Name	Description
PharmGKB entry for SLC2A11	Pharmacogenomics, SNPs, Pathways

Intellectual Property for SLC2A11 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

TryGeneCards Plus

Patent Information for SLC2A11 gene:
Search GeneIP for patents involving SLC2A11

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

TryGeneCards Plus


	EMD Millipore genomic analysis products

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Enzyme Activity Assays/Reagents
	Browse ELISpot/FluoroSpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Luminex Assays
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Recombinant/Natural Proteins		Browse Stem Cell Products
	Browse cDNA Clones		Browse Proteome Profiler Antibody Arrays

	OriGene Antibodies for SLC2A11		OriGene RNAi products in human, mouse, rat for SLC2A11
	OriGene qPCR primer pairs and template standards for SLC2A11		OriGene Protein Over-expression Lysate for SLC2A11
	OriGene Custom Mass Spec		OriGene clones in human, mouse for SLC2A11
	OriGene qSTAR qPCR primer pairs in human, mouse for SLC2A11		Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
	Browse OriGene ORF clones		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for SLC2A11		OriGene Custom Protein Services for SLC2A11

	Block miRNA regulation of human, mouse, rat SLC2A11 using miScript Target Protectors		SeqTarget long-range PCR primers for resequencing SLC2A11
	DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat SLC2A11		Predesigned siRNA for gene silencing in human, mouse, rat SLC2A11
	QuantiFast Probe-based Assays in human, mouse, rat SLC2A11		QuantiTect SYBR Green Assays in human, mouse, rat SLC2A11
	Custom PCR Arrays for SLC2A11		Search Chromatin IP Primers for SLC2A11
	Pre-validated RT² qPCR Primer Assay in human, mouse / rat SLC2A11		Search GeneGlobe Interaction Network for SLC2A11
	Regulatory tfbs in SLC2A11 promoter

	GenScript Custom Purified and Recombinant Proteins Services for SLC2A11		GenScript cDNA clones with any tag delivered in your preferred vector for SLC2A11
	GenScript Custom Assay Services for SLC2A11		GenScript Custom overexpressing Cell Line Services for SLC2A11
	CloneReady with Over 120,000 Genes		Gene Synthesis: Any Gene in Any Vector
	Vector-based siRNA and miRNA, Ready for Transfection		Gene Mutant Library, Variants up to 10^11
	Plasmid Preparation		Custom Peptide Services

Search for Antibodies & Assays

Search Tocris compounds for SLC2A11 (GTR11)

	Browse Sino Biological Proteins
	Browse Sino Biological Cell Lysates
	cDNA Clones for SLC2A11
	4000+ Proteins
	Search Sino Biological for antibodies, proteins & pathways
	Protein Production Services
	Transfection Reagents
	Protein A/G/L resins
	Isotyping reagents

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	SLC2A11 antibodies
	SLC2A11 lysates

	Search for Antibodies for SLC2A11 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for SLC2A11
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

	Browse Proteins at Cloud-Clone Corp.
	Browse Antibodies at Cloud-Clone Corp.
	Browse ELISAs at Cloud-Clone Corp.
	Browse CLIAs at Cloud-Clone Corp.

Browse ESI BIO Cell Lines and PureStem Progenitors for SLC2A11

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for SLC2A11

	SwitchGear 3'UTR luciferase reporter plasmids for SLC2A11
	SwitchGear Promoter luciferase reporter plasmids for SLC2A11

ThermoFisher Antibodies for SLC2A11

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat SLC2A11

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for SLC2A11
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for SLC2A11

LSBio Antibodies in human, mouse, rat for SLC2A11

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

View Random Gene

Category			(GIFtS: )
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes SLC2A11 gene at Home site.

Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4

GeneCards Plus

Advanced Search

Export list of displayed genes

SLC2A11 Gene

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

Aliases
for SLC2A11 gene

Summaries
for SLC2A11 gene

Genomic Views
for SLC2A11 gene

Proteins
for SLC2A11 gene

SLC2A11 Human Recombinant Protein Products:

SLC2A11 Antibody Products:

SLC2A11 Assay Products:

Domains /
Families
for SLC2A11 gene

Function
for SLC2A11 gene

Localization
for SLC2A11 gene

Pathways & Interactions
for SLC2A11 gene

Drugs & Compounds
for SLC2A11 gene

Transcripts
for SLC2A11 gene

Expression
for SLC2A11 gene

Orthologs
for SLC2A11 gene

Paralogs
for SLC2A11 gene

Genomic Variants
for SLC2A11 gene

Disorders / Diseases
for SLC2A11 gene

Publications
for SLC2A11 gene

External Searches for SLC2A11 gene

Genome Databases showing SLC2A11 gene

Other Databases showing SLC2A11 gene

Specialized Databases showing SLC2A11 gene

Intellectual Property
for SLC2A11 gene

Products
for SLC2A11 gene

View Random Gene

GeneCards Plus

Advanced Search

Export list of displayed genes

SLC2A11 Gene

Solute Carrier Family 2 (Facilitated Glucose Transporter),...

Aliasesfor SLC2A11 gene

Summariesfor SLC2A11 gene

Genomic Viewsfor SLC2A11 gene

Proteinsfor SLC2A11 gene

SLC2A11 Human Recombinant Protein Products:

SLC2A11 Antibody Products:

SLC2A11 Assay Products:

Domains /Familiesfor SLC2A11 gene

Functionfor SLC2A11 gene

Localizationfor SLC2A11 gene

Pathways & Interactionsfor SLC2A11 gene

Drugs & Compoundsfor SLC2A11 gene

Transcriptsfor SLC2A11 gene

Expression for SLC2A11 gene

Orthologsfor SLC2A11 gene

Paralogsfor SLC2A11 gene

Genomic Variantsfor SLC2A11 gene

Disorders / Diseasesfor SLC2A11 gene

Publicationsfor SLC2A11 gene

External Searches for SLC2A11 gene

Genome Databases showing SLC2A11 gene

Other Databases showing SLC2A11 gene

Specialized Databases showing SLC2A11 gene

Intellectual Propertyfor SLC2A11 gene

Productsfor SLC2A11 gene

View Random Gene

Aliases
for SLC2A11 gene

Summaries
for SLC2A11 gene

Genomic Views
for SLC2A11 gene

Proteins
for SLC2A11 gene

Domains /
Families
for SLC2A11 gene

Function
for SLC2A11 gene

Localization
for SLC2A11 gene

Pathways & Interactions
for SLC2A11 gene

Drugs & Compounds
for SLC2A11 gene

Transcripts
for SLC2A11 gene

Expression
for SLC2A11 gene

Orthologs
for SLC2A11 gene

Paralogs
for SLC2A11 gene

Genomic Variants
for SLC2A11 gene

Disorders / Diseases
for SLC2A11 gene

Publications
for SLC2A11 gene

Intellectual Property
for SLC2A11 gene

Products
for SLC2A11 gene