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Aliases for SLC2A11 Gene

Aliases for SLC2A11 Gene

  • Solute Carrier Family 2 Member 11 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 11 2 3 5
  • Glucose Transporter Type 10 3 4
  • Glucose Transporter Type 11 3 4
  • GLUT10 3 4
  • GLUT11 3 4
  • Facilitative Glucose Transporter GLUT11 3
  • Glucose Transporter-Like Protein XI 3
  • Glucose Transporter Protein 10 3
  • Glucose Transporter Protein 11 3
  • GLUT-10 4
  • GLUT-11 4

External Ids for SLC2A11 Gene

Previous GeneCards Identifiers for SLC2A11 Gene

  • GC22U990207
  • GC22P020895
  • GC22P022523
  • GC22P024198
  • GC22P007184

Summaries for SLC2A11 Gene

Entrez Gene Summary for SLC2A11 Gene

  • This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for SLC2A11 Gene

SLC2A11 (Solute Carrier Family 2 Member 11) is a Protein Coding gene. Among its related pathways are PAK Pathway and HIF1Alpha Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A1.

UniProtKB/Swiss-Prot for SLC2A11 Gene

  • Facilitative glucose transporter.

Gene Wiki entry for SLC2A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A11 Gene

Genomics for SLC2A11 Gene

Regulatory Elements for SLC2A11 Gene

Enhancers for SLC2A11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SLC2A11 on UCSC Golden Path with GeneCards custom track

Promoters for SLC2A11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC2A11 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A11 Gene

Chromosome:
22
Start:
23,856,703 bp from pter
End:
23,886,309 bp from pter
Size:
29,607 bases
Orientation:
Plus strand

Genomic View for SLC2A11 Gene

Genes around SLC2A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A11 Gene

Proteins for SLC2A11 Gene

  • Protein details for SLC2A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYW1-GTR11_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 11
    Protein Accession:
    Q9BYW1
    Secondary Accessions:
    • E9PH55
    • Q542Y4
    • Q6ICJ5
    • Q8WXF9
    • Q8WYM4

    Protein attributes for SLC2A11 Gene

    Size:
    496 amino acids
    Molecular mass:
    53703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC2A11 Gene

Proteomics data for SLC2A11 Gene at MOPED

Post-translational modifications for SLC2A11 Gene

  • Glycosylation at Asn 47
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A11 Gene

Domains & Families for SLC2A11 Gene

Gene Families for SLC2A11 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYW1

UniProtKB/Swiss-Prot:

GTR11_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A11: view

Function for SLC2A11 Gene

Molecular function for SLC2A11 Gene

UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter.
genes like me logo Genes that share phenotypes with SLC2A11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A11 Gene

Localization for SLC2A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A11 Gene COMPARTMENTS Subcellular localization image for SLC2A11 gene
Compartment Confidence
plasma membrane 5
nucleus 4

Gene Ontology (GO) - Cellular Components for SLC2A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0030054 cell junction IDA --
genes like me logo Genes that share ontologies with SLC2A11: view

Pathways & Interactions for SLC2A11 Gene

genes like me logo Genes that share pathways with SLC2A11: view

Interacting Proteins for SLC2A11 Gene

Gene Ontology (GO) - Biological Process for SLC2A11 Gene

None

No data available for SIGNOR curated interactions for SLC2A11 Gene

Drugs & Compounds for SLC2A11 Gene

(1) Drugs for SLC2A11 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SLC2A11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A11: view

Transcripts for SLC2A11 Gene

Unigene Clusters for SLC2A11 Gene

Solute carrier family 2 (facilitated glucose transporter), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - -
SP8: - -
SP9: - - -
SP10: - - - -
SP11: -
SP12: -

ExUns: 15d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for SLC2A11 Gene

GeneLoc Exon Structure for
SLC2A11
ECgene alternative splicing isoforms for
SLC2A11

Expression for SLC2A11 Gene

mRNA expression in normal human tissues for SLC2A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SLC2A11 Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A11 Gene



SOURCE GeneReport for Unigene cluster for SLC2A11 Gene Hs.743282

mRNA Expression by UniProt/SwissProt for SLC2A11 Gene

Q9BYW1-GTR11_HUMAN
Tissue specificity: Expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with SLC2A11: view

Protein tissue co-expression partners for SLC2A11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for SLC2A11 Gene

Orthologs for SLC2A11 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC2A11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC2A11 35
  • 84.01 (n)
  • 82.52 (a)
SLC2A11 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC2A11 35
  • 84.03 (n)
  • 83.43 (a)
SLC2A11 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC2A11 35
  • 97.18 (n)
  • 96.9 (a)
SLC2A11 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC2A11 35
  • 67.62 (n)
  • 63.8 (a)
-- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a11 35
  • 62.95 (n)
  • 60.56 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC560358 35
  • 59.3 (n)
  • 54.34 (a)
slc2a11b 36
  • 46 (a)
ManyToMany
Species with no ortholog for SLC2A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A11 Gene

ENSEMBL:
Gene Tree for SLC2A11 (if available)
TreeFam:
Gene Tree for SLC2A11 (if available)

Paralogs for SLC2A11 Gene

genes like me logo Genes that share paralogs with SLC2A11: view

Variants for SLC2A11 Gene

Sequence variations from dbSNP and Humsavar for SLC2A11 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs7292659 - 23,868,538(+) TGCCC(A/G)ATCAC nc-transcript-variant, reference, missense
rs9608213 - 23,882,468(+) ACGGC(A/G)GCTCC nc-transcript-variant, reference, missense
rs34096096 - 23,884,397(+) TGCTC(A/T)TCCTG nc-transcript-variant, reference, missense
rs36015336 - 23,882,787(+) GTTCC(A/G)GAAGG nc-transcript-variant, reference, missense
rs60882514 - 23,884,763(+) TCTCC(A/G)AGGAA nc-transcript-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for SLC2A11 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
esv2724041 CNV Deletion 23290073
nsv526567 CNV Gain 19592680
dgv4906n71 CNV Gain 21882294
nsv914599 CNV Gain 21882294
nsv511075 CNV Complex 20534489
dgv4907n71 CNV Loss 21882294
dgv4908n71 CNV Loss 21882294
nsv834155 CNV Gain+Loss 17160897
esv2661391 CNV Deletion 23128226
esv1010693 CNV Deletion 20482838
nsv3577 CNV Insertion 18451855
nsv914604 CNV Loss 21882294
esv2724065 CNV Deletion 23290073

Variation tolerance for SLC2A11 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.47; 85.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A11 Gene

HapMap Linkage Disequilibrium report
SLC2A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A11 Gene

Disorders for SLC2A11 Gene

Relevant External Links for SLC2A11

Genetic Association Database (GAD)
SLC2A11
Human Genome Epidemiology (HuGE) Navigator
SLC2A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A11

No disorders were found for SLC2A11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC2A11 Gene

Publications for SLC2A11 Gene

  1. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. (PMID: 11741323) Sasaki T. … Shimizu N. (Biochem. Biophys. Res. Commun. 2001) 3 4 23 67
  2. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. (PMID: 16154905) Scheepers A. … SchA1rmann A. (Mol. Membr. Biol. 2005) 3 23
  3. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern. (PMID: 14704796) Gaster M. … der H.D. (Pflugers Arch. 2004) 3 23
  4. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. (PMID: 11583593) Doege H. … SchA1rmann A. (Biochem. J. 2001) 3 23
  5. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. (PMID: 22452979) McBrayer S.K. … Shanmugam M. (Blood 2012) 3

Products for SLC2A11 Gene

Sources for SLC2A11 Gene

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