Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SLC2A10 Gene

Aliases for SLC2A10 Gene

  • Solute Carrier Family 2 Member 10 2 3
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 10 2 3 5
  • Glucose Transporter Type 10 3 4
  • GLUT-10 3 4
  • GLUT10 3 4
  • ATS 3

External Ids for SLC2A10 Gene

Previous GeneCards Identifiers for SLC2A10 Gene

  • GC20P045066
  • GC20P045976
  • GC20P046023
  • GC20P044771
  • GC20P045338
  • GC20P042079

Summaries for SLC2A10 Gene

Entrez Gene Summary for SLC2A10 Gene

  • This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

GeneCards Summary for SLC2A10 Gene

SLC2A10 (Solute Carrier Family 2 Member 10) is a Protein Coding gene. Diseases associated with SLC2A10 include arterial tortuosity syndrome and congenital short bowel syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and PAK Pathway. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A13.

UniProtKB/Swiss-Prot for SLC2A10 Gene

  • Facilitative glucose transporter.

Gene Wiki entry for SLC2A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A10 Gene

Genomics for SLC2A10 Gene

Regulatory Elements for SLC2A10 Gene

Promoters for SLC2A10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SLC2A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC2A10 Gene

Chromosome:
20
Start:
46,708,347 bp from pter
End:
46,736,347 bp from pter
Size:
28,001 bases
Orientation:
Plus strand

Genomic View for SLC2A10 Gene

Genes around SLC2A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A10 Gene

Proteins for SLC2A10 Gene

  • Protein details for SLC2A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95528-GTR10_HUMAN
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 10
    Protein Accession:
    O95528
    Secondary Accessions:
    • A8K4J6
    • Q3MIX5
    • Q9H4I6

    Protein attributes for SLC2A10 Gene

    Size:
    541 amino acids
    Molecular mass:
    56911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SLC2A10 Gene

Proteomics data for SLC2A10 Gene at MOPED

Post-translational modifications for SLC2A10 Gene

Other Protein References for SLC2A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC2A10 Gene

Domains & Families for SLC2A10 Gene

Gene Families for SLC2A10 Gene

Suggested Antigen Peptide Sequences for SLC2A10 Gene

Graphical View of Domain Structure for InterPro Entry

O95528

UniProtKB/Swiss-Prot:

GTR10_HUMAN :
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
Family:
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A10: view

Function for SLC2A10 Gene

Molecular function for SLC2A10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.28 mM for 2-deoxy-D-glucose;
UniProtKB/Swiss-Prot Function:
Facilitative glucose transporter.

Gene Ontology (GO) - Molecular Function for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 11247674
genes like me logo Genes that share ontologies with SLC2A10: view
genes like me logo Genes that share phenotypes with SLC2A10: view

Human Phenotype Ontology for SLC2A10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for SLC2A10

CRISPR Products

miRNA for SLC2A10 Gene

miRTarBase miRNAs that target SLC2A10

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC2A10 Gene

Localization for SLC2A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A10 Gene

Endomembrane system; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC2A10 Gene COMPARTMENTS Subcellular localization image for SLC2A10 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
genes like me logo Genes that share ontologies with SLC2A10: view

Pathways & Interactions for SLC2A10 Gene

genes like me logo Genes that share pathways with SLC2A10: view

Interacting Proteins for SLC2A10 Gene

Gene Ontology (GO) - Biological Process for SLC2A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046323 glucose import IBA --
GO:1904659 glucose transmembrane transport IBA,TAS --
genes like me logo Genes that share ontologies with SLC2A10: view

No data available for SIGNOR curated interactions for SLC2A10 Gene

Drugs & Compounds for SLC2A10 Gene

(1) Additional Compounds for SLC2A10 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A10: view

Transcripts for SLC2A10 Gene

Unigene Clusters for SLC2A10 Gene

Solute carrier family 2 (facilitated glucose transporter), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A10 Gene

No ASD Table

Relevant External Links for SLC2A10 Gene

GeneLoc Exon Structure for
SLC2A10
ECgene alternative splicing isoforms for
SLC2A10

Expression for SLC2A10 Gene

mRNA expression in normal human tissues for SLC2A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A10 Gene

This gene is overexpressed in Liver (x7.7).

Protein differential expression in normal tissues from HIPED for SLC2A10 Gene

This gene is overexpressed in Liver (51.9), Placenta (8.0), and Breast (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC2A10 Gene



SOURCE GeneReport for Unigene cluster for SLC2A10 Gene Hs.305971

mRNA Expression by UniProt/SwissProt for SLC2A10 Gene

O95528-GTR10_HUMAN
Tissue specificity: Widely expressed; highest levels in liver and pancreas.
genes like me logo Genes that share expression patterns with SLC2A10: view

Protein tissue co-expression partners for SLC2A10 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC2A10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SLC2A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC2A10 35
  • 98.58 (n)
  • 98.89 (a)
SLC2A10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC2A10 36
  • 82 (a)
OneToOne
SLC2A10 35
  • 84.51 (n)
  • 82.65 (a)
dog
(Canis familiaris)
Mammalia SLC2A10 35
  • 85.78 (n)
  • 84.23 (a)
SLC2A10 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc2a10 16
Slc2a10 36
  • 77 (a)
OneToOne
Slc2a10 35
  • 78.23 (n)
  • 78.17 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC2A10 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC2A10 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc2a10 35
  • 78.48 (n)
  • 78.54 (a)
chicken
(Gallus gallus)
Aves SLC2A10 36
  • 55 (a)
OneToOne
SLC2A10 35
  • 64.56 (n)
  • 60.99 (a)
lizard
(Anolis carolinensis)
Reptilia SLC2A10 36
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3328 35
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a10 35
  • 58.86 (n)
  • 57.12 (a)
Str.16625 35
zebrafish
(Danio rerio)
Actinopterygii slc2a10 36
  • 45 (a)
OneToOne
slc2a10 35
  • 53.37 (n)
  • 47.98 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
ManyToMany
ITR1 36
  • 20 (a)
ManyToMany
ITR2 36
  • 19 (a)
ManyToMany
Species with no ortholog for SLC2A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC2A10 Gene

ENSEMBL:
Gene Tree for SLC2A10 (if available)
TreeFam:
Gene Tree for SLC2A10 (if available)

Paralogs for SLC2A10 Gene

Paralogs for SLC2A10 Gene

(9) SIMAP similar genes for SLC2A10 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A10: view

Variants for SLC2A10 Gene

Sequence variations from dbSNP and Humsavar for SLC2A10 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs6018008 - 46,733,760(+) GGTTC(A/G)CCCTG nc-transcript-variant, reference, synonymous-codon, missense
rs2235491 - 46,725,652(+) GTGAG(A/G)CCCCC nc-transcript-variant, reference, missense
VAR_029535 Arterial tortuosity syndrome (ATS)
rs6094438 - 46,725,352(+) GCCGC(A/G/T)CTGTG nc-transcript-variant, reference, missense
rs7348121 - 46,733,817(+) TCGAG(A/G/T)TCTCT nc-transcript-variant, reference, missense, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC2A10 Gene

Variant ID Type Subtype PubMed ID
nsv912901 CNV Loss 21882294

Variation tolerance for SLC2A10 Gene

Residual Variation Intolerance Score: 70.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.16; 75.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A10 Gene

HapMap Linkage Disequilibrium report
SLC2A10
Human Gene Mutation Database (HGMD)
SLC2A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A10 Gene

Disorders for SLC2A10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for SLC2A10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
arterial tortuosity syndrome
  • arterial tortuosity
congenital short bowel syndrome
  • intestinal pseudo-obstruction
macular degeneration, early-onset
  • eomd
adams-oliver syndrome 5
  • aos5
gingival recession
  • gingival recession nos
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

GTR10_HUMAN
  • Arterial tortuosity syndrome (ATS) [MIM:208050]: An autosomal recessive disorder characterized by tortuosity and elongation of major arteries, often resulting in death at young age. Other typical features include aneurysms of large arteries and stenosis of the pulmonary artery, in association with facial features and several connective tissue manifestations such as soft skin and joint laxity. Histopathological findings include fragmentation of elastic fibers in the tunica media of large arteries. {ECO:0000269 PubMed:16550171, ECO:0000269 PubMed:17935213}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC2A10

Genetic Association Database (GAD)
SLC2A10
Human Genome Epidemiology (HuGE) Navigator
SLC2A10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC2A10
genes like me logo Genes that share disorders with SLC2A10: view

No data available for Genatlas for SLC2A10 Gene

Publications for SLC2A10 Gene

  1. Genetic variation of the GLUT10 glucose transporter (SLC2A10) and relationships to type 2 diabetes and intermediary traits. (PMID: 12941788) Andersen G. … Pedersen O. (Diabetes 2003) 3 4 23 48 67
  2. A novel non-sense mutation in the SLC2A10 gene of an arterial tortuosity syndrome patient of Kurdish origin. (PMID: 18818946) Zaidi S.H. … Faiyaz-Ul-Haque M. (Eur. J. Pediatr. 2009) 3 23
  3. A novel missense and a recurrent mutation in SLC2A10 gene of patients affected with arterial tortuosity syndrome. (PMID: 18774132) Faiyaz-Ul-Haque M. … Teebi A.S. (Atherosclerosis 2009) 3 23
  4. Association study of genetic polymorphisms of SLC2A10 gene and type 2 diabetes in the Taiwanese population. (PMID: 16586067) Lin W.H. … Chen Y.T. (Diabetologia 2006) 3 23
  5. Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. (PMID: 16550171) Coucke P.J. … De Paepe A. (Nat. Genet. 2006) 3 23

Products for SLC2A10 Gene

Sources for SLC2A10 Gene

Back to Top

Content